MT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.92695005
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.65433839
3synaptic vesicle exocytosis (GO:0016079)5.53949948
4locomotory exploration behavior (GO:0035641)5.41421397
5axon ensheathment in central nervous system (GO:0032291)5.40533578
6central nervous system myelination (GO:0022010)5.40533578
7glutamate secretion (GO:0014047)5.18282039
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.96804428
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.92287124
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85785168
11vocalization behavior (GO:0071625)4.82641005
12amino acid import (GO:0043090)4.77496428
13neurotransmitter-gated ion channel clustering (GO:0072578)4.77176942
14neuronal action potential propagation (GO:0019227)4.68663415
15potassium ion homeostasis (GO:0055075)4.64607705
16potassium ion import (GO:0010107)4.55580163
17regulation of synaptic vesicle exocytosis (GO:2000300)4.53021911
18protein localization to synapse (GO:0035418)4.51975906
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.51010640
20negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.50103556
21cerebellar granule cell differentiation (GO:0021707)4.45816949
22regulation of glutamate receptor signaling pathway (GO:1900449)4.42499877
23neurotransmitter secretion (GO:0007269)4.32627362
24regulation of neuronal synaptic plasticity (GO:0048168)4.30963756
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.28744767
26neuronal ion channel clustering (GO:0045161)4.14859599
27exploration behavior (GO:0035640)4.13168514
28neuron cell-cell adhesion (GO:0007158)4.11460634
29regulation of synaptic vesicle transport (GO:1902803)4.08236133
30neurotransmitter uptake (GO:0001504)4.07435471
31synaptic transmission, glutamatergic (GO:0035249)3.98580158
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.89261642
33cellular sodium ion homeostasis (GO:0006883)3.85504275
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82345506
35regulation of synapse maturation (GO:0090128)3.81741778
36cellular potassium ion homeostasis (GO:0030007)3.79138330
37gamma-aminobutyric acid transport (GO:0015812)3.76563662
38positive regulation of synaptic transmission, GABAergic (GO:0032230)3.75284149
39proline transport (GO:0015824)3.75045431
40regulation of synapse structural plasticity (GO:0051823)3.73390499
41glutamate receptor signaling pathway (GO:0007215)3.72123408
42layer formation in cerebral cortex (GO:0021819)3.70247555
43cell communication by electrical coupling (GO:0010644)3.63587349
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.62936462
45sodium ion export (GO:0071436)3.61434050
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.60268290
47neuron-neuron synaptic transmission (GO:0007270)3.59715215
48presynaptic membrane organization (GO:0097090)3.55650798
49activation of protein kinase A activity (GO:0034199)3.54366710
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.53300819
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52514069
52long-term memory (GO:0007616)3.51336805
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.50912627
54regulation of dendritic spine development (GO:0060998)3.47584723
55response to auditory stimulus (GO:0010996)3.45583213
56neurotransmitter transport (GO:0006836)3.42369024
57regulation of synaptic plasticity (GO:0048167)3.39414121
58regulation of ARF protein signal transduction (GO:0032012)3.36785766
59long-term synaptic potentiation (GO:0060291)3.36757250
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.35085082
61regulation of neurotransmitter secretion (GO:0046928)3.34977440
62synaptic vesicle endocytosis (GO:0048488)3.33848472
63regulation of amyloid precursor protein catabolic process (GO:1902991)3.31492324
64postsynaptic membrane organization (GO:0001941)3.30261608
65auditory behavior (GO:0031223)3.30025036
66regulation of excitatory postsynaptic membrane potential (GO:0060079)3.29892176
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29589191
68positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29015711
69positive regulation of membrane potential (GO:0045838)3.25575939
70regulation of cell communication by electrical coupling (GO:0010649)3.25266267
71regulation of neurotransmitter levels (GO:0001505)3.25025417
72regulation of voltage-gated calcium channel activity (GO:1901385)3.22392774
73L-glutamate transport (GO:0015813)3.21818615
74innervation (GO:0060384)3.20820649
75regulation of neurotransmitter transport (GO:0051588)3.20285626
76regulation of beta-amyloid formation (GO:1902003)3.19376573
77neuromuscular process controlling balance (GO:0050885)3.17627802
78detection of calcium ion (GO:0005513)3.16604180
79cerebellar Purkinje cell differentiation (GO:0021702)3.16412871
80negative regulation of dendrite development (GO:2000171)3.14857444
81neuromuscular process controlling posture (GO:0050884)3.13945872
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.13730368
83regulation of vesicle fusion (GO:0031338)3.13571799
84cerebellar Purkinje cell layer development (GO:0021680)3.13404802
85regulation of postsynaptic membrane potential (GO:0060078)3.10145998
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09882127
87transmission of nerve impulse (GO:0019226)3.08607007
88alanine transport (GO:0032328)3.08562889
89glycine transport (GO:0015816)3.08387836
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06099890
91positive regulation of neurotransmitter secretion (GO:0001956)3.03548602
92mechanosensory behavior (GO:0007638)3.02906210
93L-amino acid import (GO:0043092)3.02407227
94establishment of synaptic vesicle localization (GO:0097480)3.01833989
95synaptic vesicle transport (GO:0048489)3.01833989
96positive regulation of synaptic transmission (GO:0050806)3.01098101
97negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00928072
98behavioral defense response (GO:0002209)3.00037165
99behavioral fear response (GO:0001662)3.00037165
100regulation of sensory perception (GO:0051931)2.98931581
101regulation of sensory perception of pain (GO:0051930)2.98931581
102regulation of female receptivity (GO:0045924)2.98696574
103dendritic spine morphogenesis (GO:0060997)2.95269169
104response to histamine (GO:0034776)2.94992054
105prepulse inhibition (GO:0060134)2.94498219
106membrane depolarization during action potential (GO:0086010)2.94046321
107regulation of synaptic transmission (GO:0050804)2.93399931
108fear response (GO:0042596)2.92095492
109positive regulation of neurotransmitter transport (GO:0051590)2.90977574
110cell migration in hindbrain (GO:0021535)2.89380892
111synaptic transmission (GO:0007268)2.88359673
112positive regulation of dendritic spine development (GO:0060999)2.88096485
113regulation of dendritic spine morphogenesis (GO:0061001)2.85719991
114neuron recognition (GO:0008038)2.85289949
115negative regulation of dendrite morphogenesis (GO:0050774)2.80335211
116presynaptic membrane assembly (GO:0097105)2.79176999
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.78619020
118dendrite morphogenesis (GO:0048813)2.78182263
119membrane depolarization (GO:0051899)2.78105927
120learning (GO:0007612)2.77995767
121membrane hyperpolarization (GO:0060081)2.77832105
122positive regulation of synapse maturation (GO:0090129)2.77368122
123G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.76384917
124acidic amino acid transport (GO:0015800)2.75460184
125neuromuscular process (GO:0050905)2.74901454
126calcium-mediated signaling using intracellular calcium source (GO:0035584)2.73557916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.89404827
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.41654500
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.39109874
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.34262509
5GBX2_23144817_ChIP-Seq_PC3_Human3.16342347
6JARID2_20075857_ChIP-Seq_MESCs_Mouse3.10258762
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.98350165
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.98350165
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.87015424
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.83692687
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.82088384
12REST_21632747_ChIP-Seq_MESCs_Mouse2.78698213
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.77928097
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.77809407
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.69677432
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.64834681
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.56037432
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.49417896
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.47250256
20DROSHA_22980978_ChIP-Seq_HELA_Human2.42437016
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.38370485
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.34908282
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33989152
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26012068
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21611782
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00156247
27AR_21572438_ChIP-Seq_LNCaP_Human1.93684564
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91921760
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.82148742
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66253453
31* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.64556855
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59400535
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48980828
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.48101029
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45661701
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44466611
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43837359
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37675025
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36648634
40SMAD4_21799915_ChIP-Seq_A2780_Human1.34988700
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31384267
42* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25647999
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.24853730
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.22587829
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19461670
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19009126
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16491658
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16191943
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14083318
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.13984626
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.13290740
52AR_25329375_ChIP-Seq_VCAP_Human1.12473066
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11802745
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11433183
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.09765661
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09419409
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.08583202
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08145842
59KDM2B_26808549_Chip-Seq_K562_Human1.08026402
60AR_19668381_ChIP-Seq_PC3_Human1.06308018
61CTCF_27219007_Chip-Seq_Bcells_Human1.04992729
62P300_19829295_ChIP-Seq_ESCs_Human1.04519202
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03952471
64TAF15_26573619_Chip-Seq_HEK293_Human1.03941499
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03669721
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02966633
67ZNF274_21170338_ChIP-Seq_K562_Hela1.02158337
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01805542
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00643578
70GATA1_26923725_Chip-Seq_HPCs_Mouse0.99709966
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98537337
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97305902
73TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96747383
74PIAS1_25552417_ChIP-Seq_VCAP_Human0.96545034
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96289072
76ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94446440
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92941637
78OCT4_19829295_ChIP-Seq_ESCs_Human0.92930813
79TET1_21490601_ChIP-Seq_MESCs_Mouse0.92236594
80EGR1_19032775_ChIP-ChIP_M12_Human0.91652442
81* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90685463
82YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90098231
83TRIM28_21343339_ChIP-Seq_HEK293_Human0.89921048
84SMAD_19615063_ChIP-ChIP_OVARY_Human0.88515457
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87986815
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87752421
87CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87750043
88* LXR_22292898_ChIP-Seq_THP-1_Human0.87563680
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87157268
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87038830
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86932899
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86551109
93STAT3_23295773_ChIP-Seq_U87_Human0.86366869
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85938951
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.85456911
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85188001
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.83983916
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83096195
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83021466
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81662753
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.80737421
102KLF4_19829295_ChIP-Seq_ESCs_Human0.80086334
103KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79860358
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79438225
105RNF2_27304074_Chip-Seq_NSC_Mouse0.79208803
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79101649
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78746953
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.77788895
109* SMC4_20622854_ChIP-Seq_HELA_Human0.77280745
110DPY_21335234_ChIP-Seq_ESCs_Mouse0.77052920
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76967027
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.76880269
113MYC_19915707_ChIP-ChIP_AK7_Human0.76731485
114* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.76273527
115JUN_21703547_ChIP-Seq_K562_Human0.75940229
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75575723
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75564187
118BCAT_22108803_ChIP-Seq_LS180_Human0.75463399
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.74646743
120AHR_22903824_ChIP-Seq_MCF-7_Human0.73686686
121TCF4_23295773_ChIP-Seq_U87_Human0.73668961
122* RUNX2_22187159_ChIP-Seq_PCA_Human0.73664364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.36486416
2MP0003880_abnormal_central_pattern4.13829934
3MP0003635_abnormal_synaptic_transmissio3.89021095
4MP0004270_analgesia3.43025295
5* MP0009745_abnormal_behavioral_response3.22576954
6MP0001968_abnormal_touch/_nociception3.11372409
7* MP0002064_seizures3.07831828
8MP0002063_abnormal_learning/memory/cond3.07559639
9MP0002822_catalepsy2.93757898
10MP0002735_abnormal_chemical_nociception2.85237684
11MP0002736_abnormal_nociception_after2.76655107
12MP0009046_muscle_twitch2.76202522
13MP0004858_abnormal_nervous_system2.70261707
14MP0002572_abnormal_emotion/affect_behav2.65868586
15MP0003329_amyloid_beta_deposits2.60784794
16MP0001486_abnormal_startle_reflex2.60057506
17MP0002734_abnormal_mechanical_nocicepti2.55311037
18MP0002733_abnormal_thermal_nociception2.50723987
19MP0002272_abnormal_nervous_system2.50695378
20MP0005423_abnormal_somatic_nervous2.46904447
21MP0001970_abnormal_pain_threshold2.32294710
22MP0004885_abnormal_endolymph2.24323891
23MP0005646_abnormal_pituitary_gland2.10629584
24MP0001984_abnormal_olfaction2.09080423
25MP0001440_abnormal_grooming_behavior2.02891442
26MP0001501_abnormal_sleep_pattern1.96934802
27MP0008569_lethality_at_weaning1.95624192
28MP0002067_abnormal_sensory_capabilities1.87664715
29MP0002909_abnormal_adrenal_gland1.83811031
30MP0002557_abnormal_social/conspecific_i1.80114981
31MP0009780_abnormal_chondrocyte_physiolo1.77193554
32MP0006276_abnormal_autonomic_nervous1.69240541
33MP0004811_abnormal_neuron_physiology1.68269756
34* MP0000955_abnormal_spinal_cord1.62376498
35MP0004142_abnormal_muscle_tone1.60408549
36MP0000778_abnormal_nervous_system1.59120515
37MP0002184_abnormal_innervation1.58013939
38MP0003690_abnormal_glial_cell1.53365236
39MP0004924_abnormal_behavior1.49089260
40MP0005386_behavior/neurological_phenoty1.49089260
41MP0001905_abnormal_dopamine_level1.45153459
42MP0003633_abnormal_nervous_system1.44619993
43* MP0002882_abnormal_neuron_morphology1.41696523
44MP0001502_abnormal_circadian_rhythm1.40766136
45MP0002653_abnormal_ependyma_morphology1.35272717
46* MP0002066_abnormal_motor_capabilities/c1.34742382
47MP0000604_amyloidosis1.34444540
48MP0003879_abnormal_hair_cell1.33916390
49MP0003631_nervous_system_phenotype1.25396415
50MP0003075_altered_response_to1.22262808
51* MP0003634_abnormal_glial_cell1.22202994
52MP0002638_abnormal_pupillary_reflex1.18597387
53MP0001529_abnormal_vocalization1.16324299
54MP0000751_myopathy1.11775757
55MP0003787_abnormal_imprinting1.08234267
56MP0002152_abnormal_brain_morphology1.04284369
57MP0003123_paternal_imprinting1.03362008
58MP0003632_abnormal_nervous_system1.02061804
59MP0005645_abnormal_hypothalamus_physiol1.01816907
60MP0002229_neurodegeneration1.01185698
61MP0000920_abnormal_myelination0.97576992
62MP0008872_abnormal_physiological_respon0.96674805
63MP0003122_maternal_imprinting0.94553080
64MP0001963_abnormal_hearing_physiology0.94223907
65MP0008877_abnormal_DNA_methylation0.91709859
66MP0001485_abnormal_pinna_reflex0.91500867
67MP0008874_decreased_physiological_sensi0.88959491
68MP0002069_abnormal_eating/drinking_beha0.88575824
69MP0005167_abnormal_blood-brain_barrier0.88119353
70MP0005551_abnormal_eye_electrophysiolog0.87639159
71MP0005623_abnormal_meninges_morphology0.86085912
72MP0005499_abnormal_olfactory_system0.86018805
73MP0005394_taste/olfaction_phenotype0.86018805
74MP0004147_increased_porphyrin_level0.84308255
75MP0003137_abnormal_impulse_conducting0.83892262
76MP0001986_abnormal_taste_sensitivity0.83803128
77MP0002752_abnormal_somatic_nervous0.78954041
78MP0002090_abnormal_vision0.78898812
79MP0004742_abnormal_vestibular_system0.77575563
80MP0005535_abnormal_body_temperature0.75936457
81MP0004085_abnormal_heartbeat0.73396676
82MP0001346_abnormal_lacrimal_gland0.72950660
83MP0004043_abnormal_pH_regulation0.70808202
84MP0001177_atelectasis0.70286534
85MP0000579_abnormal_nail_morphology0.68380147
86MP0000631_abnormal_neuroendocrine_gland0.66933276
87MP0003283_abnormal_digestive_organ0.66137058
88MP0003183_abnormal_peptide_metabolism0.65506083
89MP0010386_abnormal_urinary_bladder0.65296800
90MP0005171_absent_coat_pigmentation0.64836445
91MP0002089_abnormal_postnatal_growth/wei0.64505163
92MP0005379_endocrine/exocrine_gland_phen0.62983809
93MP0000566_synostosis0.62787164
94MP0000026_abnormal_inner_ear0.60603610
95MP0001188_hyperpigmentation0.60334273
96MP0004130_abnormal_muscle_cell0.59743281
97MP0001664_abnormal_digestion0.58106402
98MP0000013_abnormal_adipose_tissue0.57773091
99MP0004145_abnormal_muscle_electrophysio0.53965574
100MP0004215_abnormal_myocardial_fiber0.53111213
101MP0009840_abnormal_foam_cell0.52875161
102MP0001943_abnormal_respiration0.52254937
103MP0002751_abnormal_autonomic_nervous0.52202790
104MP0010769_abnormal_survival0.52037647
105MP0001299_abnormal_eye_distance/0.50643268
106MP0004510_myositis0.50556865
107MP0003638_abnormal_response/metabolism_0.50217945
108MP0009379_abnormal_foot_pigmentation0.50175101
109MP0002837_dystrophic_cardiac_calcinosis0.49718236
110MP0005595_abnormal_vascular_smooth0.49455757
111MP0005253_abnormal_eye_physiology0.49039046
112MP0010768_mortality/aging0.48612341
113MP0005388_respiratory_system_phenotype0.48411927
114MP0002133_abnormal_respiratory_system0.48411927
115MP0005166_decreased_susceptibility_to0.47871587
116MP0003956_abnormal_body_size0.47214159
117MP0003938_abnormal_ear_development0.47125733
118MP0010770_preweaning_lethality0.47041781
119MP0000639_abnormal_adrenal_gland0.46120723

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.59204394
2Focal motor seizures (HP:0011153)6.86273315
3Focal seizures (HP:0007359)5.01772572
4Visual hallucinations (HP:0002367)4.93978739
5Atonic seizures (HP:0010819)4.71080807
6Progressive cerebellar ataxia (HP:0002073)4.43457267
7Action tremor (HP:0002345)4.32634182
8Megalencephaly (HP:0001355)4.13774358
9Epileptic encephalopathy (HP:0200134)4.11182638
10Febrile seizures (HP:0002373)3.92799619
11Supranuclear gaze palsy (HP:0000605)3.81170174
12Absence seizures (HP:0002121)3.70775486
13Generalized tonic-clonic seizures (HP:0002069)3.56550558
14Neurofibrillary tangles (HP:0002185)3.52438722
15Impaired vibration sensation in the lower limbs (HP:0002166)3.51455837
16Depression (HP:0000716)3.43635442
17Papilledema (HP:0001085)3.40702340
18Dialeptic seizures (HP:0011146)3.36794678
19Abnormal eating behavior (HP:0100738)3.35362329
20Pheochromocytoma (HP:0002666)3.19885318
21Anxiety (HP:0000739)3.15438411
22Ankle clonus (HP:0011448)3.13192516
23Tetraplegia (HP:0002445)3.12916660
24Cerebral inclusion bodies (HP:0100314)3.09240493
25Cerebral hypomyelination (HP:0006808)3.08027429
26Dysmetria (HP:0001310)3.05677659
27Dysdiadochokinesis (HP:0002075)3.05612516
28Urinary bladder sphincter dysfunction (HP:0002839)2.89709393
29Split foot (HP:0001839)2.89162145
30Neuroendocrine neoplasm (HP:0100634)2.74698510
31Postural instability (HP:0002172)2.73695090
32Increased circulating renin level (HP:0000848)2.71313489
33Neuronal loss in central nervous system (HP:0002529)2.69674212
34Hemiplegia (HP:0002301)2.68223303
35Focal dystonia (HP:0004373)2.68212437
36Truncal ataxia (HP:0002078)2.66726623
37Aplasia involving bones of the extremities (HP:0009825)2.65415375
38Aplasia involving bones of the upper limbs (HP:0009823)2.65415375
39Aplasia of the phalanges of the hand (HP:0009802)2.65415375
40Gaze-evoked nystagmus (HP:0000640)2.62682933
41Torticollis (HP:0000473)2.61283260
42Annular pancreas (HP:0001734)2.60955883
43Myotonia (HP:0002486)2.60606555
44Hemiparesis (HP:0001269)2.60295226
45Clonus (HP:0002169)2.59511975
46Insidious onset (HP:0003587)2.56027198
47Termporal pattern (HP:0011008)2.56027198
48Urinary urgency (HP:0000012)2.49798328
49Ventricular fibrillation (HP:0001663)2.49377317
50Amblyopia (HP:0000646)2.45455634
51Spastic tetraparesis (HP:0001285)2.43582090
52Abnormality of binocular vision (HP:0011514)2.42286950
53Diplopia (HP:0000651)2.42286950
54Poor eye contact (HP:0000817)2.42206918
55Polyphagia (HP:0002591)2.41883229
56Akinesia (HP:0002304)2.40433512
57Spastic gait (HP:0002064)2.38779835
58Abnormality of the lower motor neuron (HP:0002366)2.38315448
59Hyperventilation (HP:0002883)2.36048182
60Bradykinesia (HP:0002067)2.33600370
61Limb dystonia (HP:0002451)2.28106576
62Broad-based gait (HP:0002136)2.27004038
63Impaired vibratory sensation (HP:0002495)2.25831130
64Impaired social interactions (HP:0000735)2.23655723
65Abnormal social behavior (HP:0012433)2.23655723
66Craniofacial dystonia (HP:0012179)2.23113759
67Apathy (HP:0000741)2.21493151
68Genetic anticipation (HP:0003743)2.21198360
69Choreoathetosis (HP:0001266)2.19461127
70Mutism (HP:0002300)2.16914079
71Status epilepticus (HP:0002133)2.16004016
72Agitation (HP:0000713)2.13623127
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13038663
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.13038663
75Neoplasm of the peripheral nervous system (HP:0100007)2.12528908
76Obstructive sleep apnea (HP:0002870)2.10502668
77Lower limb muscle weakness (HP:0007340)2.10057438
78Abnormality of the corticospinal tract (HP:0002492)2.07261984
79Intention tremor (HP:0002080)2.07218370
80Abnormality of ocular smooth pursuit (HP:0000617)2.06343237
81Hypoventilation (HP:0002791)2.06201095
82Scanning speech (HP:0002168)2.05677460
83Incomplete penetrance (HP:0003829)2.03676651
84Rigidity (HP:0002063)2.03103784
85Hypsarrhythmia (HP:0002521)2.02932726
86Resting tremor (HP:0002322)2.02233575
87Sleep apnea (HP:0010535)2.00158667
88Stereotypic behavior (HP:0000733)2.00086611
89Delusions (HP:0000746)1.99008381
90Ulnar claw (HP:0001178)1.97739281
91CNS hypomyelination (HP:0003429)1.97412014
92Bundle branch block (HP:0011710)1.96971745
93Sensory axonal neuropathy (HP:0003390)1.95993260
94Diminished motivation (HP:0000745)1.95139414
95Lower limb asymmetry (HP:0100559)1.94355621
96Failure to thrive in infancy (HP:0001531)1.92648741
97Spinal canal stenosis (HP:0003416)1.91781156
98Gait ataxia (HP:0002066)1.89821200
99Rapidly progressive (HP:0003678)1.88670884
100Abnormal gallbladder physiology (HP:0012438)1.86417004
101Cholecystitis (HP:0001082)1.86417004
102Hypercortisolism (HP:0001578)1.86397677
103Poor suck (HP:0002033)1.86373811
104Progressive inability to walk (HP:0002505)1.85917301
105Gait imbalance (HP:0002141)1.85101495
106Specific learning disability (HP:0001328)1.84610341
107Peripheral hypomyelination (HP:0007182)1.84475870
108Foot dorsiflexor weakness (HP:0009027)1.84448401
109Epileptiform EEG discharges (HP:0011182)1.83599962
110Anosmia (HP:0000458)1.83243570
111Athetosis (HP:0002305)1.81588259
112Impaired smooth pursuit (HP:0007772)1.81407952
113Psychosis (HP:0000709)1.80940653
114Morphological abnormality of the pyramidal tract (HP:0002062)1.79351558
115Fetal akinesia sequence (HP:0001989)1.78339994
116Generalized myoclonic seizures (HP:0002123)1.78171708
117EEG with generalized epileptiform discharges (HP:0011198)1.77890667
118Postural tremor (HP:0002174)1.77841802
119Narrow nasal bridge (HP:0000446)1.77507458
120Insomnia (HP:0100785)1.75479514
121Confusion (HP:0001289)1.75222172
122Excessive salivation (HP:0003781)1.74959303
123Drooling (HP:0002307)1.74959303
124Dementia (HP:0000726)1.74383335
125Abnormality of saccadic eye movements (HP:0000570)1.73410801
126Abnormality of the periventricular white matter (HP:0002518)1.71528874
127Abnormality of the foot musculature (HP:0001436)1.70565736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.30854087
2NTRK34.04319008
3MAP3K93.25877253
4LMTK22.84467594
5GRK52.72106146
6MINK12.57607690
7DAPK22.40632677
8KSR22.39216393
9MAP3K42.34835967
10PAK62.27321824
11PRKD32.23729474
12CASK2.19257784
13MARK12.12932153
14MAP2K72.05583147
15MAP3K122.04147502
16NTRK22.02484733
17PHKG21.92251696
18PHKG11.92251696
19ARAF1.89983617
20NTRK11.87704137
21CAMKK11.67746299
22PLK21.61237319
23CDK51.56309341
24MAP3K21.46364763
25MAP2K41.44507365
26MAPK131.40434946
27PRKCG1.38777990
28PRPF4B1.36379472
29TNIK1.36087314
30DAPK11.27628197
31RIPK11.25305224
32PKN11.19798605
33SGK4941.19474674
34SGK2231.19474674
35UHMK11.17694080
36LIMK11.16014578
37CDK191.12398081
38STK381.11130146
39KSR11.09702261
40TYRO31.05412375
41CDK181.04086407
42CDK151.03153269
43RIPK41.02813376
44ADRBK11.01483835
45CDK141.00267751
46NME10.99900607
47CAMK2A0.94803535
48CDK11A0.93622795
49MAP3K130.92964286
50DMPK0.91091755
51MAPK100.89675078
52PINK10.88957203
53FES0.88009690
54TAOK10.87555046
55PRKCH0.86494501
56CAMK10.85716522
57CAMKK20.84095012
58PTK2B0.83194167
59RET0.80610191
60FGFR20.79874487
61SGK20.79368676
62SIK20.78582748
63CAMK2B0.76175304
64BMPR20.75947347
65TNK20.73836878
66LATS20.73040842
67ROCK20.67657191
68OXSR10.65118216
69DAPK30.63946424
70NEK10.63241975
71PDK10.62861087
72CAMK2G0.62321357
73TESK10.62276874
74MAP2K10.61092143
75SGK30.61061723
76MUSK0.60919020
77STK110.59891278
78MAP3K110.59227451
79RAF10.57641336
80PRKCE0.56365369
81ADRBK20.56005819
82PAK30.55529121
83MAP3K10.54951753
84CDC42BPA0.54639690
85PDPK10.53775220
86DYRK1A0.53231871
87SGK10.52611222
88NEK60.51248987
89CSNK1G20.50632537
90CAMK2D0.48864472
91CAMK40.48420049
92ALK0.48123035
93FGR0.46037928
94MOS0.45352741
95MAPKAPK50.44223636
96RPS6KA30.43847998
97PRKCZ0.43438453
98ROCK10.43411430
99ERBB20.42982417
100FYN0.42919754
101MARK20.42792321
102BRAF0.42433096
103MAPK40.42329807
104PRKCA0.41454429
105MAPK120.41256035
106BRSK10.40912128
107GRK70.40859242
108PRKG10.39986316
109PNCK0.39019918
110FER0.38549534
111PRKD10.38441770
112TESK20.38387947
113PRKACA0.37974470
114PDK20.32729675
115IRAK20.32057838
116CSNK1E0.31562184

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.69315224
2Nicotine addiction_Homo sapiens_hsa050333.08033336
3Olfactory transduction_Homo sapiens_hsa047402.82466339
4GABAergic synapse_Homo sapiens_hsa047272.65721700
5Circadian entrainment_Homo sapiens_hsa047132.65308845
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.52155270
7Glutamatergic synapse_Homo sapiens_hsa047242.52143821
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45328102
9Long-term potentiation_Homo sapiens_hsa047202.44487391
10Morphine addiction_Homo sapiens_hsa050322.35258824
11Salivary secretion_Homo sapiens_hsa049702.16460437
12Amphetamine addiction_Homo sapiens_hsa050312.11492971
13Insulin secretion_Homo sapiens_hsa049111.96524341
14Dopaminergic synapse_Homo sapiens_hsa047281.95144201
15Gastric acid secretion_Homo sapiens_hsa049711.93775711
16Collecting duct acid secretion_Homo sapiens_hsa049661.93644479
17Cholinergic synapse_Homo sapiens_hsa047251.86974027
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78519490
19Nitrogen metabolism_Homo sapiens_hsa009101.72710299
20Taste transduction_Homo sapiens_hsa047421.71495391
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67406576
22Cardiac muscle contraction_Homo sapiens_hsa042601.65198633
23Oxidative phosphorylation_Homo sapiens_hsa001901.64447240
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56060764
25Long-term depression_Homo sapiens_hsa047301.56060525
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53009318
27Vitamin B6 metabolism_Homo sapiens_hsa007501.50170503
28Serotonergic synapse_Homo sapiens_hsa047261.49477114
29Calcium signaling pathway_Homo sapiens_hsa040201.49016037
30Cocaine addiction_Homo sapiens_hsa050301.45419355
31Parkinsons disease_Homo sapiens_hsa050121.38746003
32Oxytocin signaling pathway_Homo sapiens_hsa049211.36780305
33Renin secretion_Homo sapiens_hsa049241.33547224
34Alzheimers disease_Homo sapiens_hsa050101.32129795
35GnRH signaling pathway_Homo sapiens_hsa049121.31941905
36Gap junction_Homo sapiens_hsa045401.31066833
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28288799
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27348666
39Vibrio cholerae infection_Homo sapiens_hsa051101.14305303
40cAMP signaling pathway_Homo sapiens_hsa040241.12054265
41Melanogenesis_Homo sapiens_hsa049161.09498087
42Glioma_Homo sapiens_hsa052141.05378654
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04415518
44Estrogen signaling pathway_Homo sapiens_hsa049150.90295933
45Huntingtons disease_Homo sapiens_hsa050160.87326798
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86227183
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.85419517
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85254258
49Axon guidance_Homo sapiens_hsa043600.83307372
50Fatty acid biosynthesis_Homo sapiens_hsa000610.82019301
51Histidine metabolism_Homo sapiens_hsa003400.79048437
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78909015
53Type II diabetes mellitus_Homo sapiens_hsa049300.78878645
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78810718
55ErbB signaling pathway_Homo sapiens_hsa040120.78796703
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78555589
57Pancreatic secretion_Homo sapiens_hsa049720.78444438
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77361693
59Thyroid hormone synthesis_Homo sapiens_hsa049180.76457479
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.75214053
61Dorso-ventral axis formation_Homo sapiens_hsa043200.74599148
62Arginine and proline metabolism_Homo sapiens_hsa003300.74020648
63Dilated cardiomyopathy_Homo sapiens_hsa054140.72013334
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70586835
65Bile secretion_Homo sapiens_hsa049760.69286514
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68004050
67Oocyte meiosis_Homo sapiens_hsa041140.63653022
68Phototransduction_Homo sapiens_hsa047440.60085563
69Inositol phosphate metabolism_Homo sapiens_hsa005620.55471951
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54967747
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53932078
72beta-Alanine metabolism_Homo sapiens_hsa004100.53748563
73Glucagon signaling pathway_Homo sapiens_hsa049220.52663842
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.51492160
75Prion diseases_Homo sapiens_hsa050200.50752502
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49741004
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.48577864
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47972690
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44580592
80Choline metabolism in cancer_Homo sapiens_hsa052310.44528394
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43922131
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43274414
83VEGF signaling pathway_Homo sapiens_hsa043700.43155868
84Ras signaling pathway_Homo sapiens_hsa040140.42501268
85MAPK signaling pathway_Homo sapiens_hsa040100.42364774
86Alcoholism_Homo sapiens_hsa050340.41712273
87African trypanosomiasis_Homo sapiens_hsa051430.41261131
88Type I diabetes mellitus_Homo sapiens_hsa049400.41201469
89Arginine biosynthesis_Homo sapiens_hsa002200.40952612
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40840911
91Rap1 signaling pathway_Homo sapiens_hsa040150.40401212
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40376322
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40014932
94Endocytosis_Homo sapiens_hsa041440.40003810
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39116637
96Folate biosynthesis_Homo sapiens_hsa007900.38820494
97Ovarian steroidogenesis_Homo sapiens_hsa049130.37935915
98Insulin signaling pathway_Homo sapiens_hsa049100.36544983
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34437849
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32095279
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29814491
102Rheumatoid arthritis_Homo sapiens_hsa053230.29195872
103Wnt signaling pathway_Homo sapiens_hsa043100.28751260
104Mineral absorption_Homo sapiens_hsa049780.27327400
105Hedgehog signaling pathway_Homo sapiens_hsa043400.26584282
106Circadian rhythm_Homo sapiens_hsa047100.25817819
107Pyruvate metabolism_Homo sapiens_hsa006200.24884281
108mTOR signaling pathway_Homo sapiens_hsa041500.18407811
109Hippo signaling pathway_Homo sapiens_hsa043900.18138243
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17122076
111HIF-1 signaling pathway_Homo sapiens_hsa040660.16747146
112Tight junction_Homo sapiens_hsa045300.16596515
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16299507
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13976430

Most similar genes based on co-expression Upload to Enrichr

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