MT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.75231919
2regulation of phospholipase A2 activity (GO:0032429)7.57658608
3translational termination (GO:0006415)7.28941312
4ribosomal small subunit biogenesis (GO:0042274)7.23326497
5sphingoid metabolic process (GO:0046519)7.01123674
6interferon-gamma secretion (GO:0072643)6.66148196
7keratinization (GO:0031424)6.55945411
8regulation of hypersensitivity (GO:0002883)6.21822652
9keratinocyte development (GO:0003334)6.15364764
10hemidesmosome assembly (GO:0031581)6.12869501
11establishment of skin barrier (GO:0061436)6.01155499
12sphingosine metabolic process (GO:0006670)5.96070266
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.91329638
14translational elongation (GO:0006414)5.90760813
15protein targeting to ER (GO:0045047)5.82069629
16cotranslational protein targeting to membrane (GO:0006613)5.79258387
17regulation of water loss via skin (GO:0033561)5.72847747
18maturation of SSU-rRNA (GO:0030490)5.70970503
19establishment of protein localization to endoplasmic reticulum (GO:0072599)5.65031277
20viral life cycle (GO:0019058)5.64404596
21cellular protein complex disassembly (GO:0043624)5.49347146
22keratinocyte differentiation (GO:0030216)5.45700966
23protein localization to endoplasmic reticulum (GO:0070972)5.41743284
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.37192717
25diol metabolic process (GO:0034311)5.26900042
26positive regulation of vesicle fusion (GO:0031340)5.22458081
27negative regulation of acute inflammatory response (GO:0002674)5.21546299
28regulation of chemokine secretion (GO:0090196)5.06436166
29positive regulation of interleukin-4 production (GO:0032753)4.90311865
30regulation of ruffle assembly (GO:1900027)4.76561969
31keratinocyte proliferation (GO:0043616)4.68511603
32regulation of cell proliferation involved in kidney development (GO:1901722)4.62571863
33protein complex disassembly (GO:0043241)4.56546957
34negative regulation of interleukin-2 production (GO:0032703)4.49926665
35positive regulation of chemokine secretion (GO:0090197)4.44863954
36translational initiation (GO:0006413)4.43811335
37icosanoid secretion (GO:0032309)4.32737004
38arachidonic acid secretion (GO:0050482)4.32737004
39ribosomal small subunit assembly (GO:0000028)4.29976577
40cellular response to interferon-alpha (GO:0035457)4.23741194
41negative regulation of T cell mediated immunity (GO:0002710)4.23248067
42primary alcohol catabolic process (GO:0034310)4.22369633
43sympathetic nervous system development (GO:0048485)4.21260346
44hair cycle (GO:0042633)4.17770835
45molting cycle (GO:0042303)4.17770835
46protein targeting to membrane (GO:0006612)4.16620114
47macromolecular complex disassembly (GO:0032984)4.16581973
48regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.16440019
49negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.16107233
50multicellular organismal water homeostasis (GO:0050891)4.14675486
51icosanoid transport (GO:0071715)4.10023799
52fatty acid derivative transport (GO:1901571)4.10023799
53prostanoid biosynthetic process (GO:0046457)4.07616865
54prostaglandin biosynthetic process (GO:0001516)4.07616865
55glucosamine-containing compound catabolic process (GO:1901072)4.06784471
56epidermal cell differentiation (GO:0009913)4.02671841
57cardiac right ventricle morphogenesis (GO:0003215)4.01843362
58negative regulation of interferon-gamma production (GO:0032689)3.97980038
59ribosomal large subunit biogenesis (GO:0042273)3.96479432
60inflammatory response to antigenic stimulus (GO:0002437)3.91667342
61positive regulation of interleukin-8 secretion (GO:2000484)3.86575932
62fatty acid elongation (GO:0030497)3.85465435
63epidermis development (GO:0008544)3.81980588
64bundle of His cell to Purkinje myocyte communication (GO:0086069)3.75091595
65regulation of histone H3-K27 methylation (GO:0061085)3.59939755
66regulation of interleukin-8 secretion (GO:2000482)3.58904840
67water homeostasis (GO:0030104)3.56828259
68prostaglandin metabolic process (GO:0006693)3.53972274
69prostanoid metabolic process (GO:0006692)3.53972274
70negative regulation of kidney development (GO:0090185)3.43357858
71peptide cross-linking (GO:0018149)3.41695808
72eyelid development in camera-type eye (GO:0061029)3.39432690
73cyclooxygenase pathway (GO:0019371)3.39197733
74regulation of interleukin-4 production (GO:0032673)3.34087885
75intermediate filament organization (GO:0045109)3.33553979
76ethanol metabolic process (GO:0006067)3.27589611
77carnitine metabolic process (GO:0009437)3.25174144
78nuclear-transcribed mRNA catabolic process (GO:0000956)3.18824469
79resolution of meiotic recombination intermediates (GO:0000712)3.17905065
80phosphatidylserine acyl-chain remodeling (GO:0036150)3.12935790
81negative regulation of lipase activity (GO:0060192)3.07421889
82phosphatidylinositol acyl-chain remodeling (GO:0036149)3.07295484
83mRNA catabolic process (GO:0006402)3.06434371
84positive regulation of odontogenesis (GO:0042482)3.03840237
85gland morphogenesis (GO:0022612)3.01958232
86positive regulation of cellular amine metabolic process (GO:0033240)3.01879082
87cellular response to antibiotic (GO:0071236)2.98445987
88long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.94219920
89phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.93299137
90cardiolipin metabolic process (GO:0032048)2.92656042
91CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.91720231
92T-helper cell differentiation (GO:0042093)2.91720231
93regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.87548294
94establishment of protein localization to membrane (GO:0090150)2.86916679
95glutathione biosynthetic process (GO:0006750)2.86907909
96ear development (GO:0043583)2.84088787
97fibrinolysis (GO:0042730)2.83266663
98negative regulation of keratinocyte proliferation (GO:0010839)2.82557386
99glomerular visceral epithelial cell development (GO:0072015)2.81614731
100desmosome organization (GO:0002934)11.9382026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.24038062
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.12196375
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.14787003
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.88678270
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.75065364
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.66984098
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.33884639
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26209566
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.20067522
10TP63_17297297_ChIP-ChIP_HaCaT_Human15.6359593
11GATA1_22025678_ChIP-Seq_K562_Human1.97639087
12FOXO3_23340844_ChIP-Seq_DLD1_Human1.77806379
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69035766
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69035766
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.64080030
16ZNF263_19887448_ChIP-Seq_K562_Human1.62711058
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62504673
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61028891
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54961726
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48888801
21SOX2_20726797_ChIP-Seq_SW620_Human1.46350159
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.39834128
23CJUN_26792858_Chip-Seq_BT549_Human1.37451565
24TP53_20018659_ChIP-ChIP_R1E_Mouse1.31274612
25AR_21572438_ChIP-Seq_LNCaP_Human1.29135763
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.22179054
27BCAT_22108803_ChIP-Seq_LS180_Human1.21359175
28TP63_23658742_ChIP-Seq_EP156T_Human1.19458470
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19068022
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.18608210
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17529231
32* TP63_22573176_ChIP-Seq_HFKS_Human1.12724860
33VDR_22108803_ChIP-Seq_LS180_Human1.10471230
34AHR_22903824_ChIP-Seq_MCF-7_Human1.10235238
35KLF5_25053715_ChIP-Seq_YYC3_Human1.07900254
36BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06786520
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.05922729
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04661268
39TP53_18474530_ChIP-ChIP_U2OS_Human1.03170771
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01356024
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97651835
42SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97502525
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94437749
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92653950
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91277044
46GATA4_25053715_ChIP-Seq_YYC3_Human0.89186775
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.88766877
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88386456
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88072315
50RXR_22108803_ChIP-Seq_LS180_Human0.87548518
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86965017
52CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86524885
53BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82859584
54GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81736643
55TP53_16413492_ChIP-PET_HCT116_Human0.81206730
56FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81162555
57EZH2_27304074_Chip-Seq_ESCs_Mouse0.78812500
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78407581
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.78136875
60RACK7_27058665_Chip-Seq_MCF-7_Human0.77368826
61PIAS1_25552417_ChIP-Seq_VCAP_Human0.77226639
62JARID2_20075857_ChIP-Seq_MESCs_Mouse0.76962806
63PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76646048
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.76333952
65EZH2_27294783_Chip-Seq_ESCs_Mouse0.74275558
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74106543
67JARID2_20064375_ChIP-Seq_MESCs_Mouse0.73690599
68ERG_21242973_ChIP-ChIP_JURKAT_Human0.73607223
69SOX2_27498859_Chip-Seq_STOMACH_Mouse0.72676750
70PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72612354
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72579184
72CEBPB_22108803_ChIP-Seq_LS180_Human0.71923056
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.71855552
74GATA6_21074721_ChIP-Seq_CACO-2_Human0.70222495
75RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70006422
76ATF3_27146783_Chip-Seq_COLON_Human0.69896982
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.69769987
78EGR1_19032775_ChIP-ChIP_M12_Human0.69535551
79ARNT_22903824_ChIP-Seq_MCF-7_Human0.69384618
80EZH2_18974828_ChIP-Seq_MESCs_Mouse0.69202671
81RNF2_18974828_ChIP-Seq_MESCs_Mouse0.69202671
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.68944738
83CBX2_27304074_Chip-Seq_ESCs_Mouse0.68766543
84GATA3_24758297_ChIP-Seq_MCF-7_Human0.68046184
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.67473639
86RNF2_27304074_Chip-Seq_ESCs_Mouse0.66741923
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66606550
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.66519374
89SMAD3_21741376_ChIP-Seq_EPCs_Human0.66354810
90CLOCK_20551151_ChIP-Seq_293T_Human0.63623253
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.63368098
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.62630223
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.62527196
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62199930
95FUS_26573619_Chip-Seq_HEK293_Human0.61304962
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60731055
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.59898071
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59807869
99UBF1/2_26484160_Chip-Seq_HMECs_Human0.59252421
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.58112047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.12214464
2MP0002254_reproductive_system_inflammat6.48761189
3MP0003941_abnormal_skin_development5.72605388
4MP0004381_abnormal_hair_follicle4.74829550
5MP0000383_abnormal_hair_follicle4.04488330
6MP0005501_abnormal_skin_physiology3.82207019
7MP0009379_abnormal_foot_pigmentation3.69267176
8MP0002060_abnormal_skin_morphology3.60619246
9MP0000647_abnormal_sebaceous_gland3.36463335
10MP0010234_abnormal_vibrissa_follicle3.26444975
11MP0010678_abnormal_skin_adnexa3.20536452
12MP0005275_abnormal_skin_tensile3.19367859
13MP0001216_abnormal_epidermal_layer3.10936674
14MP0010771_integument_phenotype2.74248035
15MP0002098_abnormal_vibrissa_morphology2.64900049
16MP0000467_abnormal_esophagus_morphology2.63883501
17MP0003453_abnormal_keratinocyte_physiol2.61687106
18MP0001346_abnormal_lacrimal_gland2.49944563
19MP0010352_gastrointestinal_tract_polyps2.41514915
20MP0000579_abnormal_nail_morphology2.09017739
21MP0000566_synostosis2.08130777
22MP0000377_abnormal_hair_follicle2.00554585
23MP0003136_yellow_coat_color1.94709573
24MP0000427_abnormal_hair_cycle1.88765572
25MP0001851_eye_inflammation1.88081840
26MP0002009_preneoplasia1.87951212
27MP0003566_abnormal_cell_adhesion1.82253005
28MP0004185_abnormal_adipocyte_glucose1.74885786
29MP0004947_skin_inflammation1.66521157
30MP0001243_abnormal_dermal_layer1.62890497
31MP0001191_abnormal_skin_condition1.57053961
32MP0000762_abnormal_tongue_morphology1.50724901
33MP0009931_abnormal_skin_appearance1.48722116
34MP0003638_abnormal_response/metabolism_1.38119033
35MP0002277_abnormal_respiratory_mucosa1.30940333
36MP0001340_abnormal_eyelid_morphology1.29700833
37MP0000367_abnormal_coat/_hair1.26355590
38MP0004782_abnormal_surfactant_physiolog1.21084391
39MP0005187_abnormal_penis_morphology1.17702296
40MP0005023_abnormal_wound_healing1.14568589
41MP0003011_delayed_dark_adaptation1.12381812
42MP0003705_abnormal_hypodermis_morpholog1.09665630
43MP0003315_abnormal_perineum_morphology1.09280616
44MP0000013_abnormal_adipose_tissue1.03557606
45MP0000627_abnormal_mammary_gland0.88889784
46MP0003191_abnormal_cellular_cholesterol0.85084257
47MP0000372_irregular_coat_pigmentation0.83899005
48MP0002148_abnormal_hypersensitivity_rea0.82955908
49MP0002234_abnormal_pharynx_morphology0.82593112
50MP0002095_abnormal_skin_pigmentation0.82350450
51MP0002006_tumorigenesis0.79928331
52MP0003938_abnormal_ear_development0.77130845
53MP0002177_abnormal_outer_ear0.76639477
54MP0008875_abnormal_xenobiotic_pharmacok0.75764583
55MP0005451_abnormal_body_composition0.74774173
56MP0002132_abnormal_respiratory_system0.73992460
57MP0005076_abnormal_cell_differentiation0.71963578
58MP0000613_abnormal_salivary_gland0.71708753
59MP0008004_abnormal_stomach_pH0.70877751
60MP0009053_abnormal_anal_canal0.70452268
61MP0005409_darkened_coat_color0.68828424
62MP0001666_abnormal_nutrient_absorption0.68296564
63MP0003436_decreased_susceptibility_to0.66358512
64MP0001177_atelectasis0.64054856
65MP0003183_abnormal_peptide_metabolism0.62827188
66MP0005075_abnormal_melanosome_morpholog0.60727478
67MP0004858_abnormal_nervous_system0.60128328
68MP0005647_abnormal_sex_gland0.56108879
69MP0004019_abnormal_vitamin_homeostasis0.55050270
70MP0009384_cardiac_valve_regurgitation0.54934565
71MP0002166_altered_tumor_susceptibility0.53846040
72MP0002249_abnormal_larynx_morphology0.53245763
73MP0009780_abnormal_chondrocyte_physiolo0.49512629
74MP0002163_abnormal_gland_morphology0.49473223
75MP0009250_abnormal_appendicular_skeleto0.47704201
76MP0002332_abnormal_exercise_endurance0.47312455
77MP0010030_abnormal_orbit_morphology0.46726707
78MP0001853_heart_inflammation0.45035635
79MP0003755_abnormal_palate_morphology0.44708000
80MP0005666_abnormal_adipose_tissue0.43736239
81MP0003385_abnormal_body_wall0.43201548
82MP0005085_abnormal_gallbladder_physiolo0.42178561
83MP0001784_abnormal_fluid_regulation0.41554172
84MP0002282_abnormal_trachea_morphology0.40018890
85MP0005508_abnormal_skeleton_morphology0.38812861
86MP0000470_abnormal_stomach_morphology0.38246045
87MP0005408_hypopigmentation0.37362147
88MP0002877_abnormal_melanocyte_morpholog0.37176942
89MP0000538_abnormal_urinary_bladder0.36985648
90MP0002090_abnormal_vision0.34261643
91MP0003763_abnormal_thymus_physiology0.33880251
92MP0001919_abnormal_reproductive_system0.33783539
93MP0005375_adipose_tissue_phenotype0.31932442
94MP0005165_increased_susceptibility_to0.29414131
95MP0001299_abnormal_eye_distance/0.28978493
96MP0000537_abnormal_urethra_morphology0.27030359
97MP0005379_endocrine/exocrine_gland_phen0.26721639
98MP0004272_abnormal_basement_membrane0.26542639
99MP0003936_abnormal_reproductive_system0.22480799
100MP0005390_skeleton_phenotype0.22070048

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)6.60507668
2Hypotrichosis (HP:0001006)6.32855470
3Abnormal hemoglobin (HP:0011902)5.95544875
4Parakeratosis (HP:0001036)5.71178580
5Woolly hair (HP:0002224)5.54832811
6Abnormality of cells of the erythroid lineage (HP:0012130)5.30658173
7Onycholysis (HP:0001806)5.16302950
8Abnormality of the axillary hair (HP:0100134)5.09573299
9Abnormality of secondary sexual hair (HP:0009888)5.09573299
10Fragile nails (HP:0001808)5.07175806
11Plantar hyperkeratosis (HP:0007556)4.84700832
12Reticulocytopenia (HP:0001896)4.73039679
13Abnormal number of erythroid precursors (HP:0012131)4.48884315
14Milia (HP:0001056)4.47979758
15Right ventricular cardiomyopathy (HP:0011663)4.15723578
16Congenital ichthyosiform erythroderma (HP:0007431)4.05000253
17Macrocytic anemia (HP:0001972)3.81164074
18Palmoplantar hyperkeratosis (HP:0000972)3.80897476
19Hyporeflexia of lower limbs (HP:0002600)3.75287313
20Aplasia cutis congenita (HP:0001057)3.65876063
21Septate vagina (HP:0001153)3.50461642
22Erythema (HP:0010783)3.50370550
23Palmar hyperkeratosis (HP:0010765)3.48350735
24Curly hair (HP:0002212)3.46846523
25Concave nail (HP:0001598)3.37804071
26Atrophic scars (HP:0001075)3.37503673
27White forelock (HP:0002211)3.25956323
28Distal lower limb muscle weakness (HP:0009053)3.21843630
29Anhidrosis (HP:0000970)3.19801805
30Pallor (HP:0000980)3.15951301
31Hypohidrosis (HP:0000966)3.11629414
32Nail dystrophy (HP:0008404)3.11614915
33Congenital, generalized hypertrichosis (HP:0004540)3.02315936
34Stenosis of the external auditory canal (HP:0000402)3.00803968
35Nasolacrimal duct obstruction (HP:0000579)3.00768285
36Areflexia of lower limbs (HP:0002522)2.98058691
37Popliteal pterygium (HP:0009756)2.92145155
38Corneal erosion (HP:0200020)2.86905433
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.85855706
40Patchy hypopigmentation of hair (HP:0011365)2.85181595
41Pili torti (HP:0003777)2.84525645
42Oligodontia (HP:0000677)2.80339439
43Abnormal blistering of the skin (HP:0008066)2.78648546
44Sparse eyelashes (HP:0000653)2.76553641
45Thick nail (HP:0001805)2.74332228
46Ectropion (HP:0000656)2.69097823
47Absent eyebrow (HP:0002223)2.64982751
48Alopecia of scalp (HP:0002293)2.64814452
49Hypoparathyroidism (HP:0000829)2.64687459
50Morphological abnormality of the middle ear (HP:0008609)2.63914556
51Acanthosis nigricans (HP:0000956)2.61799949
52Abnormality of the lacrimal duct (HP:0011481)2.59347157
53Increased IgE level (HP:0003212)2.56725297
54Abnormality of nail color (HP:0100643)2.55273531
55Gangrene (HP:0100758)2.52469558
56Pruritus (HP:0000989)2.52339310
57Natal tooth (HP:0000695)2.51096178
58Abnormality of the salivary glands (HP:0010286)2.47609342
59Conical tooth (HP:0000698)2.41687278
60Sparse scalp hair (HP:0002209)2.41544010
61Erythroderma (HP:0001019)2.41367439
62Advanced eruption of teeth (HP:0006288)2.37698566
63Aplasia involving bones of the extremities (HP:0009825)2.36688864
64Aplasia involving bones of the upper limbs (HP:0009823)2.36688864
65Aplasia of the phalanges of the hand (HP:0009802)2.36688864
66Conjunctival hamartoma (HP:0100780)2.35410548
67Mesangial abnormality (HP:0001966)2.33571177
68Ventricular tachycardia (HP:0004756)2.33300826
69Abnormal hair laboratory examination (HP:0003328)2.30992335
70Brittle hair (HP:0002299)2.19102975
71Abnormality of the nasolacrimal system (HP:0000614)2.18278087
72Hypoplastic labia majora (HP:0000059)2.17624431
73Depressed nasal ridge (HP:0000457)2.15449597
74Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.10703377
75Ankyloglossia (HP:0010296)2.07297688
76Wide intermamillary distance (HP:0006610)2.04622849
77Type I diabetes mellitus (HP:0100651)2.04378245
78Palmoplantar keratoderma (HP:0000982)2.03649522
79Abnormality of the nasal septum (HP:0000419)1.99342548
80Abnormality of the labia majora (HP:0012881)1.96852176
81Overfolded helix (HP:0000396)1.96269337
82Xanthomatosis (HP:0000991)1.95298328
83Severe Myopia (HP:0011003)1.95033493
84Malignant hyperthermia (HP:0002047)1.92879787
85Abnormality of the phalanges of the 5th finger (HP:0004213)1.92609471
86Seborrheic dermatitis (HP:0001051)1.92227837
87Asplenia (HP:0001746)1.89557675
88Skin pits (HP:0100276)1.89124599
89Hypoplasia of dental enamel (HP:0006297)1.88342821
90Abnormally folded helix (HP:0008544)1.86994533
91Dry skin (HP:0000958)1.85409412
92Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84566620
93Abnormality of the fetal cardiovascular system (HP:0010948)1.81356812
94Abnormal umbilical cord blood vessels (HP:0011403)1.81356812
95Single umbilical artery (HP:0001195)1.81356812
96Absent hair (HP:0002298)1.79716159
97Pterygium (HP:0001059)1.75807509
98Hypoplastic pelvis (HP:0008839)1.73903540
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.72374011
100Obstructive sleep apnea (HP:0002870)1.68373013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R8.76715381
2MET3.42328053
3MAP3K33.37502985
4MAP3K23.13393789
5MST42.98355428
6STK242.96060534
7GRK72.73871339
8STK102.62285792
9TRPM72.59656548
10TGFBR22.49641217
11ERBB32.40381949
12LRRK22.24142425
13MAPKAPK32.21745106
14MOS1.99683670
15LATS11.76463195
16EIF2AK21.73061108
17GRK51.69117244
18FRK1.58408510
19FER1.55048870
20RPS6KB21.53921866
21LATS21.50967124
22FGFR21.47037621
23RIPK11.43376859
24TYK21.38434167
25CASK1.31230806
26MAP3K141.24083702
27MAPK151.22091925
28TGFBR11.18704627
29PASK1.13569702
30MAPKAPK51.12696342
31INSRR1.11458759
32NME21.05941100
33PIM21.03433160
34PIK3CG1.01756612
35ILK0.99103784
36CDK190.86920518
37ADRBK10.86319630
38MAP2K20.77128195
39GRK10.76872039
40ACVR1B0.76391535
41MAP2K10.76041185
42PBK0.76024650
43DYRK1B0.75431163
44BCR0.73692062
45FGFR40.73468712
46NTRK20.69605452
47NME10.68125818
48EPHA30.66578309
49OXSR10.63327455
50VRK10.61851843
51EEF2K0.60663009
52PRKD10.60043643
53MAP3K10.59939621
54TTN0.57875505
55ERN10.56147626
56MAPKAPK20.55856345
57STK110.55076703
58JAK20.54267058
59BMPR1B0.52912233
60BLK0.50635696
61EPHA20.50098433
62ROCK20.49119308
63PRKCE0.44182790
64PTK60.43230178
65EPHA40.38458500
66MAP3K120.38108949
67FGFR30.37641151
68STK390.34354916
69MAPK40.33296301
70IKBKB0.33018096
71DYRK1A0.32172690
72MAPK120.31330851
73IGF1R0.29764781
74MAP2K60.28259868
75EPHB20.27871306
76TNIK0.27805686
77MAP3K110.27761574
78CDK50.27684194
79TAOK10.26134267
80ABL10.25463471
81MAP2K40.24357137
82STK38L0.24001871
83KSR20.23953165
84SRC0.23356672
85CDK60.22778006
86PAK30.21348726
87PRKCA0.20944599
88IRAK40.20267120
89IKBKE0.20114998
90PRKCQ0.19893162
91ERBB20.19261576
92MAPK110.18979452
93BTK0.18627820
94CSNK1E0.18398023
95PRKACA0.17541814
96ROCK10.16960702
97SYK0.14919705
98CSNK1D0.14735127
99BRSK20.14256226
100ERBB40.14035814

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.35978384
2Cyanoamino acid metabolism_Homo sapiens_hsa004605.37082064
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.24350203
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.92194539
5Linoleic acid metabolism_Homo sapiens_hsa005912.91607340
6Phenylalanine metabolism_Homo sapiens_hsa003602.62151086
7Caffeine metabolism_Homo sapiens_hsa002322.51020830
8Sphingolipid metabolism_Homo sapiens_hsa006002.47824494
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.39228643
10Histidine metabolism_Homo sapiens_hsa003402.32589218
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.31404023
12Arachidonic acid metabolism_Homo sapiens_hsa005902.23379113
13Chemical carcinogenesis_Homo sapiens_hsa052042.15463026
14Fatty acid elongation_Homo sapiens_hsa000622.08929812
15Tyrosine metabolism_Homo sapiens_hsa003501.81615309
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70332804
17Ether lipid metabolism_Homo sapiens_hsa005651.57350070
18Retinol metabolism_Homo sapiens_hsa008301.46710146
19beta-Alanine metabolism_Homo sapiens_hsa004101.24468661
20Ovarian steroidogenesis_Homo sapiens_hsa049131.24292118
21Renin secretion_Homo sapiens_hsa049241.21443356
22Glutathione metabolism_Homo sapiens_hsa004801.21091627
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.17791003
24Long-term depression_Homo sapiens_hsa047301.04906991
25Fatty acid degradation_Homo sapiens_hsa000711.03301186
26VEGF signaling pathway_Homo sapiens_hsa043700.98108038
27GnRH signaling pathway_Homo sapiens_hsa049120.93511190
28Axon guidance_Homo sapiens_hsa043600.93256165
29ABC transporters_Homo sapiens_hsa020100.92139693
30Basal cell carcinoma_Homo sapiens_hsa052170.89698534
31Nitrogen metabolism_Homo sapiens_hsa009100.85602653
32Pancreatic secretion_Homo sapiens_hsa049720.78678656
33Sphingolipid signaling pathway_Homo sapiens_hsa040710.78656359
34ECM-receptor interaction_Homo sapiens_hsa045120.76755507
35Serotonergic synapse_Homo sapiens_hsa047260.76518119
36Salivary secretion_Homo sapiens_hsa049700.75017568
37Amoebiasis_Homo sapiens_hsa051460.74875373
38Sulfur metabolism_Homo sapiens_hsa009200.74351061
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70254298
40Staphylococcus aureus infection_Homo sapiens_hsa051500.67869175
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66814995
42p53 signaling pathway_Homo sapiens_hsa041150.61236589
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61093885
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59794107
45Oxidative phosphorylation_Homo sapiens_hsa001900.59623465
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58370017
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57600329
48Fatty acid metabolism_Homo sapiens_hsa012120.57195029
49Platelet activation_Homo sapiens_hsa046110.56412861
50Adherens junction_Homo sapiens_hsa045200.55792273
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.54478104
52Melanogenesis_Homo sapiens_hsa049160.53627941
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52639888
54Mineral absorption_Homo sapiens_hsa049780.51611723
55Hippo signaling pathway_Homo sapiens_hsa043900.51328660
56Complement and coagulation cascades_Homo sapiens_hsa046100.51161906
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.49967295
58Bladder cancer_Homo sapiens_hsa052190.49897687
59Fatty acid biosynthesis_Homo sapiens_hsa000610.47688111
60Pertussis_Homo sapiens_hsa051330.47333626
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47098706
62Arginine biosynthesis_Homo sapiens_hsa002200.46670459
63Hedgehog signaling pathway_Homo sapiens_hsa043400.46416748
64PPAR signaling pathway_Homo sapiens_hsa033200.45736746
65Proteoglycans in cancer_Homo sapiens_hsa052050.45624607
66Cardiac muscle contraction_Homo sapiens_hsa042600.45266798
67Gastric acid secretion_Homo sapiens_hsa049710.43688453
68Tight junction_Homo sapiens_hsa045300.43452091
69MicroRNAs in cancer_Homo sapiens_hsa052060.43171284
70Ras signaling pathway_Homo sapiens_hsa040140.42266474
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40696386
72Dorso-ventral axis formation_Homo sapiens_hsa043200.40608579
73Alzheimers disease_Homo sapiens_hsa050100.38898744
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38817172
75Thyroid cancer_Homo sapiens_hsa052160.38594776
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37798372
77Choline metabolism in cancer_Homo sapiens_hsa052310.37230739
78Fat digestion and absorption_Homo sapiens_hsa049750.35118941
79Butanoate metabolism_Homo sapiens_hsa006500.34717131
80RNA polymerase_Homo sapiens_hsa030200.34020757
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33025044
82Notch signaling pathway_Homo sapiens_hsa043300.32493509
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31883888
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31830939
85Glutamatergic synapse_Homo sapiens_hsa047240.29739571
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.29565580
87Steroid biosynthesis_Homo sapiens_hsa001000.29306150
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27839159
89Oxytocin signaling pathway_Homo sapiens_hsa049210.25440915
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25130802
91Protein digestion and absorption_Homo sapiens_hsa049740.24673517
92Legionellosis_Homo sapiens_hsa051340.24064217
93Gap junction_Homo sapiens_hsa045400.23770877
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22834645
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21311189
96Phototransduction_Homo sapiens_hsa047440.20946208
97Cocaine addiction_Homo sapiens_hsa050300.20350872
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19546797
99Hepatitis C_Homo sapiens_hsa051600.19545622
100Circadian rhythm_Homo sapiens_hsa047100.19510037

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