MTA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.90678653
2heterochromatin organization (GO:0070828)4.83653944
3DNA unwinding involved in DNA replication (GO:0006268)4.78201804
4ribosomal small subunit biogenesis (GO:0042274)4.14897170
5regulation of translational fidelity (GO:0006450)4.14245822
6regulation of mammary gland epithelial cell proliferation (GO:0033599)4.10230602
7negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.02541521
8RNA stabilization (GO:0043489)3.88908641
9mRNA stabilization (GO:0048255)3.88908641
10protein localization to kinetochore (GO:0034501)3.78275631
11nuclear pore complex assembly (GO:0051292)3.70985422
12regulation of posttranscriptional gene silencing (GO:0060147)3.70324130
13regulation of gene silencing by miRNA (GO:0060964)3.70324130
14regulation of gene silencing by RNA (GO:0060966)3.70324130
15convergent extension (GO:0060026)3.68124315
16negative regulation of RNA splicing (GO:0033119)3.67919431
17peptidyl-arginine omega-N-methylation (GO:0035247)3.66962000
18nuclear pore organization (GO:0006999)3.62282793
19peptidyl-lysine dimethylation (GO:0018027)3.57256616
20glucocorticoid receptor signaling pathway (GO:0042921)3.48686447
21negative regulation of mRNA processing (GO:0050686)3.47180345
22polarized epithelial cell differentiation (GO:0030859)3.44889817
23positive regulation of histone deacetylation (GO:0031065)3.44003952
24planar cell polarity pathway involved in neural tube closure (GO:0090179)3.43117672
25paraxial mesoderm development (GO:0048339)3.40710024
26folic acid-containing compound biosynthetic process (GO:0009396)3.39445440
27maternal placenta development (GO:0001893)3.38403414
28chromatin assembly (GO:0031497)3.38196331
29negative regulation of mRNA metabolic process (GO:1903312)3.36236298
303-UTR-mediated mRNA stabilization (GO:0070935)3.33689308
31establishment of apical/basal cell polarity (GO:0035089)3.32239165
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.31396953
33intracellular estrogen receptor signaling pathway (GO:0030520)3.27650632
34semaphorin-plexin signaling pathway (GO:0071526)3.26947132
35sister chromatid segregation (GO:0000819)3.26946175
36peptidyl-arginine methylation (GO:0018216)3.26754884
37peptidyl-arginine N-methylation (GO:0035246)3.26754884
38negative regulation of erythrocyte differentiation (GO:0045647)3.25087840
39regulation of hippo signaling (GO:0035330)3.22287321
40dosage compensation (GO:0007549)3.21878684
41DNA duplex unwinding (GO:0032508)3.20526957
42spliceosomal tri-snRNP complex assembly (GO:0000244)3.19781464
43mitotic nuclear envelope disassembly (GO:0007077)3.19200058
44DNA geometric change (GO:0032392)3.17027192
45regulation of glucose import in response to insulin stimulus (GO:2001273)3.15965553
46protein-DNA complex disassembly (GO:0032986)3.15111000
47nucleosome disassembly (GO:0006337)3.15111000
48negative regulation of histone methylation (GO:0031061)3.11070974
49Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.10940891
50mitotic sister chromatid segregation (GO:0000070)3.10795443
51protein localization to chromosome, centromeric region (GO:0071459)3.10411135
52viral transcription (GO:0019083)3.09934100
53regulation of mRNA stability (GO:0043488)3.08336327
54regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.07072666
55regulation of histone H3-K27 methylation (GO:0061085)3.05683607
56proline biosynthetic process (GO:0006561)3.02963482
57protein retention in ER lumen (GO:0006621)3.02442646
58nuclear envelope disassembly (GO:0051081)3.01419994
59membrane disassembly (GO:0030397)3.01419994
60mitotic sister chromatid cohesion (GO:0007064)3.01092863
61activation of Rac GTPase activity (GO:0032863)2.99680225
62cellular response to epidermal growth factor stimulus (GO:0071364)2.99371356
63translational termination (GO:0006415)2.96865685
64hippo signaling (GO:0035329)2.96556015
65apoptotic process involved in morphogenesis (GO:0060561)2.92454562
66regulation of stem cell maintenance (GO:2000036)2.91162594
67regulation of RNA export from nucleus (GO:0046831)2.90055387
68trophectodermal cell differentiation (GO:0001829)2.89787668
69regulation of establishment of planar polarity (GO:0090175)2.89787298
70positive regulation of SMAD protein import into nucleus (GO:0060391)2.89612404
71cell-cell junction maintenance (GO:0045217)2.89264578
72NLS-bearing protein import into nucleus (GO:0006607)2.89089699
73regulation of sister chromatid cohesion (GO:0007063)2.86847169
74positive regulation of RNA splicing (GO:0033120)2.85938629
75adherens junction assembly (GO:0034333)2.85879103
76regulation of early endosome to late endosome transport (GO:2000641)2.84395697
77regulation of RNA stability (GO:0043487)2.83863844
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83792333
79mitotic chromosome condensation (GO:0007076)2.83057392
80maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81155140
81alternative mRNA splicing, via spliceosome (GO:0000380)2.80520635
82apoptotic process involved in development (GO:1902742)2.80143193
83regulation of translational termination (GO:0006449)2.79443066
84cochlea morphogenesis (GO:0090103)2.79369505
85formation of translation preinitiation complex (GO:0001731)2.78761757
86histone arginine methylation (GO:0034969)2.78341995
87embryonic eye morphogenesis (GO:0048048)2.78340922
88protein complex localization (GO:0031503)2.78173464
89neural tube development (GO:0021915)2.77784237
90establishment or maintenance of monopolar cell polarity (GO:0061339)2.76729220
91establishment of monopolar cell polarity (GO:0061162)2.76729220
92regulation of chromatin binding (GO:0035561)2.73857542
93regulation of nucleobase-containing compound transport (GO:0032239)2.73408142
94negative regulation of cell size (GO:0045792)2.72920343
95cytoplasmic mRNA processing body assembly (GO:0033962)2.72603970
96positive regulation of gene expression, epigenetic (GO:0045815)2.72420297
97negative regulation of fatty acid transport (GO:2000192)2.72224376
98eye morphogenesis (GO:0048592)2.71321003
99positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.71144315
100translational elongation (GO:0006414)2.69506006
101negative regulation of DNA repair (GO:0045738)2.68163655
102histone H2A monoubiquitination (GO:0035518)2.68112241
103regulation of histone H3-K9 methylation (GO:0051570)2.67261159
104corticosteroid receptor signaling pathway (GO:0031958)2.67052955
105mannose metabolic process (GO:0006013)2.66695657
106positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.65635169
107regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.65426048
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64703570
109positive regulation of transcription regulatory region DNA binding (GO:2000679)2.64380974
110regulation of protein heterodimerization activity (GO:0043497)2.63889182
111regulation of SMAD protein import into nucleus (GO:0060390)2.62447782
112translational initiation (GO:0006413)2.61418386
113pore complex assembly (GO:0046931)2.61304421
114DNA replication-dependent nucleosome organization (GO:0034723)2.61219304
115DNA replication-dependent nucleosome assembly (GO:0006335)2.61219304
116focal adhesion assembly (GO:0048041)2.61023876
117cell-substrate adherens junction assembly (GO:0007045)2.61023876
118maturation of SSU-rRNA (GO:0030490)2.60944028
119atrioventricular valve morphogenesis (GO:0003181)2.60823459
120cytoskeletal anchoring at plasma membrane (GO:0007016)2.60223317
121histone H4-K12 acetylation (GO:0043983)2.60074732
122IMP biosynthetic process (GO:0006188)2.59339648
123positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59287599
124lymph vessel development (GO:0001945)2.58891786
125cell migration in hindbrain (GO:0021535)2.58875648
126stress granule assembly (GO:0034063)2.58544146
127endothelial cell chemotaxis (GO:0035767)2.57940472
128positive regulation of chromosome segregation (GO:0051984)2.57736873
129cellular protein complex localization (GO:0034629)2.57533448
130epithelial cell differentiation involved in prostate gland development (GO:0060742)2.56072031
131outer ear morphogenesis (GO:0042473)2.55720840
132cell-substrate junction assembly (GO:0007044)2.55103588
133negative regulation of striated muscle cell differentiation (GO:0051154)2.54968177
134regulation of NFAT protein import into nucleus (GO:0051532)2.53375674
135gene silencing (GO:0016458)2.52693621
136mitotic G1 DNA damage checkpoint (GO:0031571)2.50066758
137negative regulation of glial cell proliferation (GO:0060253)2.49720759
138protein complex disassembly (GO:0043241)2.49497672
139regulation of fatty acid beta-oxidation (GO:0031998)2.49379079
140DNA topological change (GO:0006265)2.49246843
141response to epidermal growth factor (GO:0070849)2.49175820
142nuclear envelope organization (GO:0006998)2.49169047
143histone H4 deacetylation (GO:0070933)2.49004877
144positive regulation of protein deacetylation (GO:0090312)2.48648292
145RNA localization (GO:0006403)2.48130159
146retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.45566443
147insulin-like growth factor receptor signaling pathway (GO:0048009)2.45346924
148negative regulation of myotube differentiation (GO:0010832)2.44688590
149embryonic camera-type eye morphogenesis (GO:0048596)2.44390618
150positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43288955
151activation of MAPKKK activity (GO:0000185)2.42320637
152protein localization to microtubule (GO:0035372)2.41745414
153camera-type eye morphogenesis (GO:0048593)2.41396420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.48716373
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.77162136
3MYC_22102868_ChIP-Seq_BL_Human3.78963120
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.62340428
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06359541
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88289288
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.56477622
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51749446
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50318799
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40949153
11VDR_21846776_ChIP-Seq_THP-1_Human2.39052721
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33048777
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.30272902
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29121233
15* KDM2B_26808549_Chip-Seq_DND41_Human2.23736286
16* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18035231
17TCF7_22412390_ChIP-Seq_EML_Mouse2.17406545
18* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07172691
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.05252212
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03961630
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00725831
22* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97217127
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.96651398
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91982426
25ZFP281_27345836_Chip-Seq_ESCs_Mouse1.82138338
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.82092072
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.80432420
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70926994
29CIITA_25753668_ChIP-Seq_RAJI_Human1.64022819
30P68_20966046_ChIP-Seq_HELA_Human1.62203577
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.60721701
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60615627
33* XRN2_22483619_ChIP-Seq_HELA_Human1.60387391
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.59239770
35* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57504781
36KDM2B_26808549_Chip-Seq_JURKAT_Human1.56899265
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54299944
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.52094921
39ZNF263_19887448_ChIP-Seq_K562_Human1.51971607
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50986776
41UTX_26944678_Chip-Seq_JUKART_Human1.50596824
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49964440
43* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49896526
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49538608
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47926893
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47767102
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47384612
48* LXR_22292898_ChIP-Seq_THP-1_Human1.47093906
49DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46138916
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45860627
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45492069
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45360375
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.44733074
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44709825
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42954773
56* RACK7_27058665_Chip-Seq_MCF-7_Human1.42865269
57MAF_26560356_Chip-Seq_TH1_Human1.42606372
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41540459
59SMC4_20622854_ChIP-Seq_HELA_Human1.41478724
60AR_21909140_ChIP-Seq_LNCAP_Human1.40412960
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39756728
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39600954
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38418506
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38418506
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38418506
66* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38391485
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37074927
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36954096
69ATF3_27146783_Chip-Seq_COLON_Human1.36132645
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32815738
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31891503
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.31313502
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30332664
74NCOR1_26117541_ChIP-Seq_K562_Human1.29813435
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28974446
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28712568
77CHD1_26751641_Chip-Seq_LNCaP_Human1.26851254
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25412234
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.23936021
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22965194
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22451404
82KDM2B_26808549_Chip-Seq_K562_Human1.21934779
83* CREB1_26743006_Chip-Seq_LNCaP_Human1.20056482
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20047376
85CLOCK_20551151_ChIP-Seq_293T_Human1.18801568
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18727424
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17565384
88* RUNX1_27514584_Chip-Seq_MCF-7_Human1.17549848
89* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17169774
90* KDM5A_27292631_Chip-Seq_BREAST_Human1.16922480
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15877447
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15844283
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15462595
94* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14897335
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14816358
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14317055
97* CTCF_27219007_Chip-Seq_Bcells_Human1.12929225
98TP53_22127205_ChIP-Seq_IMR90_Human1.10623369
99NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10336479
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10295809
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07215661
102VDR_24763502_ChIP-Seq_THP-1_Human1.05956456
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04202113
104MAF_26560356_Chip-Seq_TH2_Human1.03659537
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03301572
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.02755997
107POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02621307
108FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02618368
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02602265
110* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02300698
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01926902
112PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01110855
113SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01088641
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00725746
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99638876
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99543938
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99432700
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99262014
119THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99072931
120RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99030387
121TTF2_22483619_ChIP-Seq_HELA_Human0.97592461
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96633201
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.95706090
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95695910
125* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95313423
126RARA_24833708_ChIP-Seq_LIVER_Mouse0.94836757
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94597679
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93138104
129FOXP1_21924763_ChIP-Seq_HESCs_Human0.91277566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.91283530
2MP0010030_abnormal_orbit_morphology3.01664969
3MP0005076_abnormal_cell_differentiation2.88125698
4MP0010352_gastrointestinal_tract_polyps2.85947081
5MP0004858_abnormal_nervous_system2.78873305
6MP0000566_synostosis2.51400930
7MP0005623_abnormal_meninges_morphology2.36114518
8MP0003111_abnormal_nucleus_morphology2.27749454
9MP0003123_paternal_imprinting2.23231854
10MP0004957_abnormal_blastocyst_morpholog2.21426947
11MP0000537_abnormal_urethra_morphology2.21239833
12MP0009053_abnormal_anal_canal2.09552967
13MP0004197_abnormal_fetal_growth/weight/2.07957827
14MP0001730_embryonic_growth_arrest1.97357291
15MP0003077_abnormal_cell_cycle1.96216540
16MP0005409_darkened_coat_color1.95761178
17MP0002084_abnormal_developmental_patter1.93387478
18MP0009379_abnormal_foot_pigmentation1.90128284
19MP0010094_abnormal_chromosome_stability1.89872610
20MP0004233_abnormal_muscle_weight1.89472748
21MP0000733_abnormal_muscle_development1.85771552
22MP0001849_ear_inflammation1.84688410
23MP0002085_abnormal_embryonic_tissue1.81932094
24MP0001672_abnormal_embryogenesis/_devel1.81389501
25MP0005380_embryogenesis_phenotype1.81389501
26MP0003119_abnormal_digestive_system1.77834347
27MP0000350_abnormal_cell_proliferation1.77155774
28MP0009278_abnormal_bone_marrow1.76191174
29MP0003984_embryonic_growth_retardation1.74768589
30MP0002088_abnormal_embryonic_growth/wei1.73892358
31MP0001697_abnormal_embryo_size1.68792058
32MP0000428_abnormal_craniofacial_morphol1.67437330
33MP0002653_abnormal_ependyma_morphology1.67130934
34MP0005666_abnormal_adipose_tissue1.65496027
35MP0002086_abnormal_extraembryonic_tissu1.65466990
36MP0003566_abnormal_cell_adhesion1.61812085
37MP0001348_abnormal_lacrimal_gland1.61413964
38MP0003567_abnormal_fetal_cardiomyocyte1.54250884
39MP0003315_abnormal_perineum_morphology1.53871557
40MP0003121_genomic_imprinting1.51726774
41MP0003115_abnormal_respiratory_system1.50758476
42MP0003693_abnormal_embryo_hatching1.49802063
43MP0002396_abnormal_hematopoietic_system1.45638296
44MP0002080_prenatal_lethality1.45431041
45MP0004808_abnormal_hematopoietic_stem1.44314746
46MP0010307_abnormal_tumor_latency1.44273869
47MP0003300_gastrointestinal_ulcer1.40414209
48MP0005451_abnormal_body_composition1.39301130
49MP0003385_abnormal_body_wall1.38535418
50MP0008007_abnormal_cellular_replicative1.36322736
51MP0003122_maternal_imprinting1.36087121
52MP0002877_abnormal_melanocyte_morpholog1.35780074
53MP0009672_abnormal_birth_weight1.34260898
54MP0002932_abnormal_joint_morphology1.34221154
55MP0003942_abnormal_urinary_system1.34142133
56MP0003283_abnormal_digestive_organ1.32359566
57MP0008438_abnormal_cutaneous_collagen1.31123199
58MP0003935_abnormal_craniofacial_develop1.30111279
59MP0001346_abnormal_lacrimal_gland1.30083005
60MP0009703_decreased_birth_body1.29328604
61MP0002925_abnormal_cardiovascular_devel1.29036882
62MP0000049_abnormal_middle_ear1.28438940
63MP0002249_abnormal_larynx_morphology1.25912699
64MP0010630_abnormal_cardiac_muscle1.23429226
65MP0003890_abnormal_embryonic-extraembry1.22280460
66MP0005501_abnormal_skin_physiology1.22216000
67MP0008057_abnormal_DNA_replication1.22109286
68MP0003453_abnormal_keratinocyte_physiol1.20450271
69MP0001915_intracranial_hemorrhage1.19780483
70MP0002697_abnormal_eye_size1.19198683
71MP0004185_abnormal_adipocyte_glucose1.18210704
72MP0005023_abnormal_wound_healing1.16362900
73MP0002111_abnormal_tail_morphology1.15664004
74MP0008932_abnormal_embryonic_tissue1.15089062
75MP0000534_abnormal_ureter_morphology1.13329980
76MP0002796_impaired_skin_barrier1.13117111
77MP0003279_aneurysm1.12938193
78MP0001293_anophthalmia1.12716884
79MP0010234_abnormal_vibrissa_follicle1.12583706
80MP0002009_preneoplasia1.11553045
81MP0004264_abnormal_extraembryonic_tissu1.11537272
82MP0000266_abnormal_heart_morphology1.08859173
83MP0002092_abnormal_eye_morphology1.08759273
84MP0006054_spinal_hemorrhage1.08063059
85MP0009384_cardiac_valve_regurgitation1.06204548
86MP0008770_decreased_survivor_rate1.05831935
87MP0000432_abnormal_head_morphology1.05284205
88MP0000579_abnormal_nail_morphology1.04125838
89MP0005058_abnormal_lysosome_morphology1.03146440
90MP0002116_abnormal_craniofacial_bone1.02556978
91MP0008961_abnormal_basal_metabolism1.01422704
92MP0004087_abnormal_muscle_fiber1.01149122
93MP0003861_abnormal_nervous_system1.00741479
94MP0002234_abnormal_pharynx_morphology1.00522434
95MP0003937_abnormal_limbs/digits/tail_de1.00208207
96MP0000751_myopathy0.99048167
97MP0000762_abnormal_tongue_morphology0.98344269
98MP0004272_abnormal_basement_membrane0.98179224
99MP0000703_abnormal_thymus_morphology0.98056203
100MP0003755_abnormal_palate_morphology0.97582684
101MP0000750_abnormal_muscle_regeneration0.95821006
102MP0005670_abnormal_white_adipose0.93084249
103MP0002282_abnormal_trachea_morphology0.92521734
104MP0002089_abnormal_postnatal_growth/wei0.91625844
105MP0002114_abnormal_axial_skeleton0.91576280
106MP0003091_abnormal_cell_migration0.89621191
107MP0003303_peritoneal_inflammation0.88536154
108MP0003938_abnormal_ear_development0.85678839
109MP0000462_abnormal_digestive_system0.85657825
110MP0004381_abnormal_hair_follicle0.85570440
111MP0000678_abnormal_parathyroid_gland0.83878176
112MP0002098_abnormal_vibrissa_morphology0.83723934
113MP0001545_abnormal_hematopoietic_system0.83380905
114MP0005397_hematopoietic_system_phenotyp0.83380905
115MP0000003_abnormal_adipose_tissue0.82863804
116MP0001784_abnormal_fluid_regulation0.82425555
117* MP0000313_abnormal_cell_death0.82205194
118MP0006138_congestive_heart_failure0.82068329
119MP0004859_abnormal_synaptic_plasticity0.81743311
120MP0002233_abnormal_nose_morphology0.81251086
121MP0001340_abnormal_eyelid_morphology0.79456939
122MP0001188_hyperpigmentation0.78953277
123MP0002060_abnormal_skin_morphology0.78736392
124MP0002108_abnormal_muscle_morphology0.78457844
125MP0000759_abnormal_skeletal_muscle0.78354461
126MP0008789_abnormal_olfactory_epithelium0.77721900
127MP0002128_abnormal_blood_circulation0.77414707
128MP0009250_abnormal_appendicular_skeleto0.77305811
129MP0005375_adipose_tissue_phenotype0.77147488
130MP0000467_abnormal_esophagus_morphology0.77097234
131MP0005257_abnormal_intraocular_pressure0.76896822
132MP0000477_abnormal_intestine_morphology0.75672385
133MP0005508_abnormal_skeleton_morphology0.75601111

Predicted human phenotypes

RankGene SetZ-score
1Renal duplication (HP:0000075)3.76025539
2Obstructive sleep apnea (HP:0002870)3.61324266
3Shallow orbits (HP:0000586)3.56055964
4Hyperacusis (HP:0010780)3.53918181
5Protrusio acetabuli (HP:0003179)3.45266605
6Short 4th metacarpal (HP:0010044)3.31203980
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.31203980
8Broad face (HP:0000283)3.25066379
9Ependymoma (HP:0002888)2.84936119
10Increased nuchal translucency (HP:0010880)2.82888138
11Abnormality of the 4th metacarpal (HP:0010012)2.81725829
12Cerebral aneurysm (HP:0004944)2.65933168
13Turricephaly (HP:0000262)2.61989751
14Abnormality of the distal phalanx of the thumb (HP:0009617)2.60226400
15Asymmetry of the thorax (HP:0001555)2.58621586
16Selective tooth agenesis (HP:0001592)2.58080231
17Long palpebral fissure (HP:0000637)2.57806280
18Increased density of long bones (HP:0006392)2.56990086
19Broad distal phalanx of finger (HP:0009836)2.51854061
20Biconcave vertebral bodies (HP:0004586)2.46197030
21Renovascular hypertension (HP:0100817)2.44992730
22Genu recurvatum (HP:0002816)2.42973517
23Abnormality of the astrocytes (HP:0100707)2.39510577
24Astrocytoma (HP:0009592)2.39510577
25Insomnia (HP:0100785)2.38861050
26Rib fusion (HP:0000902)2.38650084
27Bowel diverticulosis (HP:0005222)2.37388843
28Broad palm (HP:0001169)2.37057923
29Rectal prolapse (HP:0002035)2.36690865
30Pseudobulbar signs (HP:0002200)2.35249490
31Broad thumb (HP:0011304)2.34328913
32Elfin facies (HP:0004428)2.33968151
33Bladder diverticulum (HP:0000015)2.33924912
34Deep palmar crease (HP:0006191)2.33047471
35Flat acetabular roof (HP:0003180)2.31857111
36Ulnar bowing (HP:0003031)2.29576333
37Ankle contracture (HP:0006466)2.29016261
38Missing ribs (HP:0000921)2.28491216
39Thin ribs (HP:0000883)2.25034187
40Mitral valve prolapse (HP:0001634)2.24776025
41Abnormality of the phalanges of the hallux (HP:0010057)2.19511125
42Premature rupture of membranes (HP:0001788)2.19469743
43Deviation of the thumb (HP:0009603)2.19075705
44Mitral regurgitation (HP:0001653)2.18589420
45Overriding aorta (HP:0002623)2.18558570
46Patellar dislocation (HP:0002999)2.17987764
47Germ cell neoplasia (HP:0100728)2.16864061
48Bronchomalacia (HP:0002780)2.16065887
49Abnormality of the aortic arch (HP:0012303)2.14942666
50Proximal placement of thumb (HP:0009623)2.14354310
51Short 5th finger (HP:0009237)2.13611152
52Deviation of the hallux (HP:0010051)2.12567937
53Distal lower limb amyotrophy (HP:0008944)2.12560935
54Dysmetric saccades (HP:0000641)2.11899535
55Increased connective tissue (HP:0009025)2.11163102
56Skin tags (HP:0010609)2.11043611
57Hallux valgus (HP:0001822)2.10365012
58Thin bony cortex (HP:0002753)2.10294892
59Pointed chin (HP:0000307)2.07652338
60Long eyelashes (HP:0000527)2.07610618
61Abnormality of the thoracic spine (HP:0100711)2.07211379
62Supernumerary ribs (HP:0005815)2.06941769
63Abnormality of the calcaneus (HP:0008364)2.04649588
64Partial duplication of thumb phalanx (HP:0009944)2.02601390
65Trigonocephaly (HP:0000243)2.00377254
66High pitched voice (HP:0001620)1.98427089
67High anterior hairline (HP:0009890)1.98311923
68Abnormality of the lower motor neuron (HP:0002366)1.97562120
69Precocious puberty (HP:0000826)1.96904826
70Dislocated radial head (HP:0003083)1.96556848
71Abnormality of the diencephalon (HP:0010662)1.96209421
72Flat cornea (HP:0007720)1.96177645
73Premature skin wrinkling (HP:0100678)1.94655547
74Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.93916761
75Neoplasm of striated muscle (HP:0009728)1.93891635
76Abnormal number of incisors (HP:0011064)1.93434697
77Macroorchidism (HP:0000053)1.93076132
78Broad phalanges of the hand (HP:0009768)1.91922706
79Fibroma (HP:0010614)1.91815869
80Ankyloglossia (HP:0010296)1.91768099
81Heterotopia (HP:0002282)1.91583922
82Partial duplication of the phalanx of hand (HP:0009999)1.91233593
83Cervical subluxation (HP:0003308)1.89702676
84Abnormality of the radial head (HP:0003995)1.89680785
85Stridor (HP:0010307)1.88979793
86Fibrous tissue neoplasm (HP:0012316)1.88888064
87Truncus arteriosus (HP:0001660)1.88169941
88Preauricular skin tag (HP:0000384)1.87345787
89Medulloblastoma (HP:0002885)1.86498798
90Abnormality of the fingertips (HP:0001211)1.86099713
91Abnormality of oral frenula (HP:0000190)1.83293585
92Short phalanx of the thumb (HP:0009660)1.83012304
93Adenoma sebaceum (HP:0009720)1.82677137
94Angiofibromas (HP:0010615)1.82677137
95Metaphyseal cupping (HP:0003021)1.82205657
96Self-mutilation (HP:0000742)1.81649902
97Broad toe (HP:0001837)1.81594674
98Septate vagina (HP:0001153)1.80822947
99Neoplasm of the oral cavity (HP:0100649)1.80609154
100Abnormality of the Achilles tendon (HP:0005109)1.80465414
101Subacute progressive viral hepatitis (HP:0006572)1.78764668
102Vertebral fusion (HP:0002948)1.78629662
103Basal cell carcinoma (HP:0002671)1.78499653
104Volvulus (HP:0002580)1.78321719
105Supernumerary bones of the axial skeleton (HP:0009144)1.77965955
106Lymphangioma (HP:0100764)1.77748042
107Distal upper limb amyotrophy (HP:0007149)1.77726243
108Upper limb amyotrophy (HP:0009129)1.77726243
109Broad finger (HP:0001500)1.77557644
110Atresia of the external auditory canal (HP:0000413)1.75617539
111Annular pancreas (HP:0001734)1.75267937
112Vertebral arch anomaly (HP:0008438)1.74294975
113Overlapping toe (HP:0001845)1.73958236
114Fragile skin (HP:0001030)1.73786783
115Aneurysm (HP:0002617)1.73154300
116Neoplasm of the heart (HP:0100544)1.73092223
117Aplasia involving bones of the extremities (HP:0009825)1.72973558
118Aplasia involving bones of the upper limbs (HP:0009823)1.72973558
119Aplasia of the phalanges of the hand (HP:0009802)1.72973558
120Short 1st metacarpal (HP:0010034)1.72583365
121Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.72583365
122Achilles tendon contracture (HP:0001771)1.72538086
123Difficulty climbing stairs (HP:0003551)1.72384386
124Arnold-Chiari malformation (HP:0002308)1.71909371
125Sacral dimple (HP:0000960)1.71853005
126Bowed forearm bones (HP:0003956)1.71695833
127Bowing of the arm (HP:0006488)1.71695833
128Camptodactyly of toe (HP:0001836)1.71461621
129Colon cancer (HP:0003003)1.70621906
130Dilatation of the ascending aorta (HP:0005111)1.70583202
131Disproportionate tall stature (HP:0001519)1.70404483
132Obsessive-compulsive behavior (HP:0000722)1.70255167
133Malignant gastrointestinal tract tumors (HP:0006749)1.69771034
134Gastrointestinal carcinoma (HP:0002672)1.69771034
135Centrally nucleated skeletal muscle fibers (HP:0003687)1.69696467
136Broad metatarsal (HP:0001783)1.69012228
137Urethral obstruction (HP:0000796)1.68399290
138Syringomyelia (HP:0003396)1.68393192
139Spinal cord lesions (HP:0100561)1.68393192
140Broad long bones (HP:0005622)1.68207791
141Enlarged penis (HP:0000040)1.67651224
142Spina bifida occulta (HP:0003298)1.67488660
143Glioma (HP:0009733)1.67228992
144Hyperthyroidism (HP:0000836)1.66867178
145Thoracic kyphosis (HP:0002942)1.66513877
146Sparse lateral eyebrow (HP:0005338)1.66499633
147Broad phalanx (HP:0006009)1.65605653
148Buphthalmos (HP:0000557)1.65359885
149Hypercalcemia (HP:0003072)1.64757595
150Lower limb amyotrophy (HP:0007210)1.64173655
151Atelectasis (HP:0100750)1.62962570
152Trismus (HP:0000211)1.61289070
153Bowel incontinence (HP:0002607)1.60947134
154Abnormality of the humeroradial joint (HP:0100744)1.60645623
155Neonatal hypoglycemia (HP:0001998)1.60035076
156Increased variability in muscle fiber diameter (HP:0003557)1.58552914
157Advanced eruption of teeth (HP:0006288)1.58126668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.89312476
2MAP3K104.22042117
3TRIB34.09529431
4SMG13.87870476
5CDK123.84409362
6PKN23.70450082
7ICK3.03735665
8CDC72.62406718
9PRPF4B2.40595510
10TTN1.98986069
11NEK21.93083255
12PDGFRA1.85164102
13IRAK31.81537687
14NME21.78693738
15PTK61.75586890
16MTOR1.57144736
17RPS6KB21.55265462
18LATS21.54875304
19ALK1.52088945
20BMX1.47486844
21LRRK21.46847496
22CDK41.44045578
23STK101.42138442
24SIK11.36334118
25ERN11.36325751
26EPHA21.35650720
27RIPK11.34590401
28PRKD31.33465417
29PAK41.32719240
30SCYL21.32402640
31CDK61.31450282
32TYRO31.30973656
33PAK21.22480915
34PASK1.21859840
35DDR21.21430330
36NTRK11.19344755
37LATS11.16063545
38DMPK1.10749830
39MAP3K81.08768905
40SIK21.06405390
41CDK71.05636598
42BRD41.04062863
43NEK11.01948914
44TTK1.00634699
45TAOK10.99766343
46GRK60.94121037
47MAP3K130.92835391
48MAP2K20.89066267
49MAP2K30.88790991
50ILK0.86979944
51FGFR10.86561981
52CHEK10.84856267
53MAP3K90.81098850
54CAMK1G0.81016154
55FLT30.80052715
56TGFBR10.79837633
57ARAF0.79629358
58TSSK60.78422004
59EPHB20.77352313
60MAP4K10.76928184
61STK30.76715196
62BRAF0.76570817
63PTK20.72133443
64* CDK20.70015872
65AKT20.68542572
66PDPK10.67682437
67PDGFRB0.66676750
68RPS6KA40.65780882
69KSR20.65558195
70ATR0.65487928
71MARK20.65093007
72MAP3K70.64593128
73CAMK1D0.64253274
74CAMKK10.64249247
75PRKD20.61173313
76PLK10.60264596
77RPS6KA10.59823530
78TAOK20.58741820
79MKNK10.58714159
80IRAK20.58181441
81HIPK20.57714893
82ATM0.57248146
83RPS6KL10.56197961
84RPS6KC10.56197961
85AURKB0.56140850
86RET0.54294209
87MST1R0.53501692
88FGFR20.52460070
89STK40.50559417
90RPS6KA20.50553348
91UHMK10.48493867
92MKNK20.47752660
93PAK10.46908568
94CSNK1E0.45833587
95RPS6KA60.45389777
96CDK10.44543339
97CDK80.44078686
98FGFR30.43747765
99WEE10.43536749
100PIM10.42953151
101CDK90.42700003
102MAPK10.42503860
103MAP3K110.41944383
104CHEK20.41687258
105DYRK1B0.41577607
106MAPK150.38773213
107AKT10.38626253
108TNK20.37925428
109MAPKAPK20.37768165
110MAPK100.37574072
111MAPK110.36871747
112* MAPK140.36478288
113PRKDC0.36292488
114CDC42BPA0.36078020
115KDR0.35917251
116TESK20.35867773
117MAP3K10.35538975
118CSNK1D0.35282181
119PRKCH0.35022316
120PAK60.34988046
121AURKA0.34772105
122FGFR40.34067437
123MAPK80.32679948
124GSK3B0.32431831
125MELK0.31737722
126BRSK10.31612438
127CDK11A0.30948245
128CDK150.30907668
129MET0.29540904
130PDK10.29370854
131TESK10.28742212

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.37745653
2mRNA surveillance pathway_Homo sapiens_hsa030152.20021733
3Spliceosome_Homo sapiens_hsa030402.16639023
4RNA transport_Homo sapiens_hsa030132.14432158
5Basal cell carcinoma_Homo sapiens_hsa052172.07138741
6Chronic myeloid leukemia_Homo sapiens_hsa052202.06114359
7One carbon pool by folate_Homo sapiens_hsa006701.97461626
8Cell cycle_Homo sapiens_hsa041101.92893756
9Notch signaling pathway_Homo sapiens_hsa043301.82198642
10MicroRNAs in cancer_Homo sapiens_hsa052061.74516151
11Hippo signaling pathway_Homo sapiens_hsa043901.69966385
12Mismatch repair_Homo sapiens_hsa034301.68555224
13mTOR signaling pathway_Homo sapiens_hsa041501.67111147
14Lysine degradation_Homo sapiens_hsa003101.66008029
15Adherens junction_Homo sapiens_hsa045201.65551407
16Colorectal cancer_Homo sapiens_hsa052101.55174875
17Bladder cancer_Homo sapiens_hsa052191.54501519
18Proteoglycans in cancer_Homo sapiens_hsa052051.53926018
19Small cell lung cancer_Homo sapiens_hsa052221.53518975
20Thyroid cancer_Homo sapiens_hsa052161.53354629
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.51087552
22Hedgehog signaling pathway_Homo sapiens_hsa043401.50031128
23Base excision repair_Homo sapiens_hsa034101.47918893
24HTLV-I infection_Homo sapiens_hsa051661.45679929
25Ribosome_Homo sapiens_hsa030101.45099849
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43785281
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43551502
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42032576
29Endometrial cancer_Homo sapiens_hsa052131.38440239
30Non-small cell lung cancer_Homo sapiens_hsa052231.34209274
31Acute myeloid leukemia_Homo sapiens_hsa052211.34172815
32Focal adhesion_Homo sapiens_hsa045101.33039063
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32255948
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31649285
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31070840
36Other glycan degradation_Homo sapiens_hsa005111.30197407
37Sulfur relay system_Homo sapiens_hsa041221.29866315
38Viral myocarditis_Homo sapiens_hsa054161.29522815
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29412650
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26709736
41Prion diseases_Homo sapiens_hsa050201.23179515
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.20445888
43Viral carcinogenesis_Homo sapiens_hsa052031.20256926
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16890031
45Glioma_Homo sapiens_hsa052141.16804469
46Wnt signaling pathway_Homo sapiens_hsa043101.16798865
47VEGF signaling pathway_Homo sapiens_hsa043701.16115050
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15818467
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15587675
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13952575
51Choline metabolism in cancer_Homo sapiens_hsa052311.13926918
52Pentose phosphate pathway_Homo sapiens_hsa000301.08894660
53Pancreatic cancer_Homo sapiens_hsa052121.07968654
54TGF-beta signaling pathway_Homo sapiens_hsa043501.06310122
55Phospholipase D signaling pathway_Homo sapiens_hsa040721.05691544
56Oocyte meiosis_Homo sapiens_hsa041141.04122000
57Pathways in cancer_Homo sapiens_hsa052001.00309010
58ECM-receptor interaction_Homo sapiens_hsa045120.99796268
59Renal cell carcinoma_Homo sapiens_hsa052110.98933841
60p53 signaling pathway_Homo sapiens_hsa041150.98823172
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98194214
62Prostate cancer_Homo sapiens_hsa052150.98138748
63Estrogen signaling pathway_Homo sapiens_hsa049150.94141177
64GnRH signaling pathway_Homo sapiens_hsa049120.93083021
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92937167
66AMPK signaling pathway_Homo sapiens_hsa041520.89109177
67Insulin signaling pathway_Homo sapiens_hsa049100.87457103
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87401982
69Nucleotide excision repair_Homo sapiens_hsa034200.87110405
70HIF-1 signaling pathway_Homo sapiens_hsa040660.86945798
71RNA degradation_Homo sapiens_hsa030180.86260659
72Fructose and mannose metabolism_Homo sapiens_hsa000510.86017010
73Insulin resistance_Homo sapiens_hsa049310.85461684
74Axon guidance_Homo sapiens_hsa043600.85425095
75Melanogenesis_Homo sapiens_hsa049160.85167601
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85099952
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84517241
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83194411
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82937419
80Long-term potentiation_Homo sapiens_hsa047200.82416113
81Glucagon signaling pathway_Homo sapiens_hsa049220.82198979
82Tight junction_Homo sapiens_hsa045300.80845054
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80101496
84Hepatitis B_Homo sapiens_hsa051610.79859793
85Dilated cardiomyopathy_Homo sapiens_hsa054140.79230614
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77738053
87Antigen processing and presentation_Homo sapiens_hsa046120.75549371
88Inositol phosphate metabolism_Homo sapiens_hsa005620.75303697
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74212951
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.73916979
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73733090
92Dorso-ventral axis formation_Homo sapiens_hsa043200.73652148
93Biosynthesis of amino acids_Homo sapiens_hsa012300.73331401
94Rap1 signaling pathway_Homo sapiens_hsa040150.71051897
95T cell receptor signaling pathway_Homo sapiens_hsa046600.70488337
96Melanoma_Homo sapiens_hsa052180.69300358
97B cell receptor signaling pathway_Homo sapiens_hsa046620.68491521
98Apoptosis_Homo sapiens_hsa042100.67527516
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67434120
100Toxoplasmosis_Homo sapiens_hsa051450.67302375
101Amoebiasis_Homo sapiens_hsa051460.67145507
102FoxO signaling pathway_Homo sapiens_hsa040680.67140233
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.66387010
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65147886
105Prolactin signaling pathway_Homo sapiens_hsa049170.64819962
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.62391259
107Herpes simplex infection_Homo sapiens_hsa051680.61985548
108Galactose metabolism_Homo sapiens_hsa000520.61892079
109MAPK signaling pathway_Homo sapiens_hsa040100.60595114
110ErbB signaling pathway_Homo sapiens_hsa040120.60438228
111Epstein-Barr virus infection_Homo sapiens_hsa051690.59709799
112Homologous recombination_Homo sapiens_hsa034400.58735823
113Shigellosis_Homo sapiens_hsa051310.58116350
114Platelet activation_Homo sapiens_hsa046110.57902744
115Hepatitis C_Homo sapiens_hsa051600.56698749
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55916745
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55580482
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.54510238
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49791214
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49738904
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49506181
122Gap junction_Homo sapiens_hsa045400.47227431

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