MTA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.59538679
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.32743102
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.32743102
4negative regulation of erythrocyte differentiation (GO:0045647)4.31439588
5protein localization to kinetochore (GO:0034501)3.95733330
6antigen processing and presentation of endogenous antigen (GO:0019883)3.87801926
7nuclear pore complex assembly (GO:0051292)3.67758867
8regulation of histone H3-K27 methylation (GO:0061085)3.59802631
9nuclear pore organization (GO:0006999)3.57525676
10Golgi transport vesicle coating (GO:0048200)3.55291136
11COPI coating of Golgi vesicle (GO:0048205)3.55291136
12mitotic nuclear envelope disassembly (GO:0007077)3.52237586
13folic acid-containing compound biosynthetic process (GO:0009396)3.51848558
14negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.46933131
15positive regulation of gamma-delta T cell activation (GO:0046645)3.42410005
16dosage compensation (GO:0007549)3.40587996
17negative regulation of RNA splicing (GO:0033119)3.33018729
18protein localization to chromosome, centromeric region (GO:0071459)3.31039335
19regulation of gamma-delta T cell differentiation (GO:0045586)3.29042124
20regulation of translational fidelity (GO:0006450)3.28795252
21membrane disassembly (GO:0030397)3.27731376
22nuclear envelope disassembly (GO:0051081)3.27731376
23regulation of mammary gland epithelial cell proliferation (GO:0033599)3.18921437
24DNA strand elongation involved in DNA replication (GO:0006271)3.16841495
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14659131
26DNA duplex unwinding (GO:0032508)3.14581865
27regulation of chromatin binding (GO:0035561)3.13037677
283-UTR-mediated mRNA stabilization (GO:0070935)3.11062411
29DNA geometric change (GO:0032392)3.10590825
30mitotic chromosome condensation (GO:0007076)3.02102774
31protein localization to endosome (GO:0036010)3.00887239
32DNA strand elongation (GO:0022616)2.99400961
33peptidyl-arginine omega-N-methylation (GO:0035247)2.99355490
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98308939
35mRNA stabilization (GO:0048255)2.98051284
36RNA stabilization (GO:0043489)2.98051284
37activation of Rac GTPase activity (GO:0032863)2.97590261
38DNA replication initiation (GO:0006270)2.97121483
39viral transcription (GO:0019083)2.94908093
40negative regulation of histone methylation (GO:0031061)2.94758577
41maturation of SSU-rRNA (GO:0030490)2.93545120
42IMP biosynthetic process (GO:0006188)2.93498714
43apoptotic process involved in morphogenesis (GO:0060561)2.93212396
44heterochromatin organization (GO:0070828)2.90908427
45translesion synthesis (GO:0019985)2.90550105
46ribosomal small subunit assembly (GO:0000028)2.88098533
47DNA replication-dependent nucleosome assembly (GO:0006335)2.87974682
48DNA replication-dependent nucleosome organization (GO:0034723)2.87974682
49embryonic process involved in female pregnancy (GO:0060136)2.87486015
50negative regulation of mRNA processing (GO:0050686)2.86557365
51regulation of gamma-delta T cell activation (GO:0046643)2.86077530
52translational termination (GO:0006415)2.85059121
53regulation of RNA export from nucleus (GO:0046831)2.84233925
54sister chromatid segregation (GO:0000819)2.84225549
55mitotic sister chromatid cohesion (GO:0007064)2.84193627
56formation of translation preinitiation complex (GO:0001731)2.83554705
57regulation of nucleobase-containing compound transport (GO:0032239)2.80887184
58pore complex assembly (GO:0046931)2.80689448
59T cell selection (GO:0045058)2.79331913
60nuclear envelope organization (GO:0006998)2.76160485
61alternative mRNA splicing, via spliceosome (GO:0000380)2.75264805
62regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74380445
63regulation of translational termination (GO:0006449)2.73375217
64NIK/NF-kappaB signaling (GO:0038061)2.71583529
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70414696
66proline biosynthetic process (GO:0006561)2.69559747
67positive T cell selection (GO:0043368)2.69196106
68pentose-phosphate shunt (GO:0006098)2.67919929
69positive thymic T cell selection (GO:0045059)2.67700108
70regulation of histone H3-K9 methylation (GO:0051570)2.66397953
71mitotic sister chromatid segregation (GO:0000070)2.66245238
72negative regulation of mRNA metabolic process (GO:1903312)2.66193571
73nucleobase biosynthetic process (GO:0046112)2.64368939
74cell-substrate adherens junction assembly (GO:0007045)2.64211920
75focal adhesion assembly (GO:0048041)2.64211920
76response to muramyl dipeptide (GO:0032495)2.63872375
77regulation of protein heterodimerization activity (GO:0043497)2.63275362
78B cell receptor signaling pathway (GO:0050853)2.63269937
79chromatin assembly (GO:0031497)2.62877979
80telomere maintenance via semi-conservative replication (GO:0032201)2.62186337
81translational elongation (GO:0006414)2.62087622
82translational initiation (GO:0006413)2.57635564
83T cell apoptotic process (GO:0070231)2.57598988
84pre-miRNA processing (GO:0031054)2.56819927
85regulation of defense response to virus by virus (GO:0050690)2.56641601
86IMP metabolic process (GO:0046040)2.56631740
87mitotic G1 DNA damage checkpoint (GO:0031571)2.55987175
88regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.55668425
89regulation of NFAT protein import into nucleus (GO:0051532)2.55561195
90protein export from nucleus (GO:0006611)2.55333914
91negative regulation of cell size (GO:0045792)2.55203551
92positive regulation of histone deacetylation (GO:0031065)2.54935303
93ribosomal small subunit biogenesis (GO:0042274)2.54636977
94Arp2/3 complex-mediated actin nucleation (GO:0034314)2.52582985
95regulation of glucose import in response to insulin stimulus (GO:2001273)2.51207686
96regulation of spindle organization (GO:0090224)2.50799797
97intracellular estrogen receptor signaling pathway (GO:0030520)2.50783538
98DNA replication checkpoint (GO:0000076)2.50708886
99adherens junction assembly (GO:0034333)2.50607092
100positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.49409623
101positive regulation of chromosome segregation (GO:0051984)2.49309974
102retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47813391
103positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47646359
104mucosal-associated lymphoid tissue development (GO:0048537)2.47363962
105Peyers patch development (GO:0048541)2.47363962
106DNA conformation change (GO:0071103)2.46766920
107regulation of integrin activation (GO:0033623)2.46643997
108regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46276163
109positive regulation of keratinocyte differentiation (GO:0045618)2.46133633
110regulation of mRNA stability (GO:0043488)2.46103105
111spliceosomal tri-snRNP complex assembly (GO:0000244)2.46059345
112ribosome assembly (GO:0042255)2.45486254
113antigen processing and presentation via MHC class Ib (GO:0002475)2.45350106
114negative T cell selection (GO:0043383)2.45246596
115positive regulation of B cell differentiation (GO:0045579)2.45020428
116regulation of sister chromatid cohesion (GO:0007063)2.44839895
117DNA topological change (GO:0006265)2.43554424
118mannose metabolic process (GO:0006013)2.42781196
119cellular response to virus (GO:0098586)2.42130211
120negative thymic T cell selection (GO:0045060)2.41788014
121T cell lineage commitment (GO:0002360)2.41409695
122histone mRNA catabolic process (GO:0071044)2.40682201
123cell-substrate junction assembly (GO:0007044)2.40422131
124modulation by symbiont of host cellular process (GO:0044068)2.40093828
125maternal placenta development (GO:0001893)2.39900160
126glucocorticoid receptor signaling pathway (GO:0042921)2.39442150
127histone H2A monoubiquitination (GO:0035518)2.39397180
128negative regulation of cell killing (GO:0031342)2.38071661
129negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.38071661
130epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37670108
131megakaryocyte development (GO:0035855)2.37366352
132mRNA splicing, via spliceosome (GO:0000398)2.36738427
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.36738427
134peptidyl-arginine methylation (GO:0018216)2.36728968
135peptidyl-arginine N-methylation (GO:0035246)2.36728968
136mitotic recombination (GO:0006312)2.36534718
137protein localization to chromosome (GO:0034502)2.35609168
138thymic T cell selection (GO:0045061)2.35457397
139pinocytosis (GO:0006907)2.34415874
140nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.34354722
141regulation of RNA stability (GO:0043487)2.34054701
142cellular response to epidermal growth factor stimulus (GO:0071364)2.33972359
143postreplication repair (GO:0006301)2.33695737
144protein-DNA complex disassembly (GO:0032986)2.33421278
145nucleosome disassembly (GO:0006337)2.33421278
146RNA splicing, via transesterification reactions (GO:0000375)2.32821915
147G1 DNA damage checkpoint (GO:0044783)2.32243452
148telomere maintenance via recombination (GO:0000722)2.31586926
149modulation by virus of host process (GO:0019054)2.31008138
150CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.30848052
151V(D)J recombination (GO:0033151)2.30325242
152positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.30013960
153morphogenesis of an endothelium (GO:0003159)2.29025200
154endothelial tube morphogenesis (GO:0061154)2.29025200
155cellular response to interleukin-4 (GO:0071353)2.28746332
156trophectodermal cell differentiation (GO:0001829)2.28608306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.53143824
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.03713484
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.55662222
4MYC_22102868_ChIP-Seq_BL_Human3.48811675
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16860182
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70294960
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.67250320
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.63212933
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37954930
10VDR_21846776_ChIP-Seq_THP-1_Human2.35450942
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06363340
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03637433
13LXR_22292898_ChIP-Seq_THP-1_Human1.94048021
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84241135
15CIITA_25753668_ChIP-Seq_RAJI_Human1.81613351
16TCF7_22412390_ChIP-Seq_EML_Mouse1.77730759
17* MAF_26560356_Chip-Seq_TH1_Human1.76361866
18* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75627443
19* XRN2_22483619_ChIP-Seq_HELA_Human1.74437952
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71015973
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70263370
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68228221
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.67673920
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66952607
25* UTX_26944678_Chip-Seq_JUKART_Human1.66747131
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66713724
27RACK7_27058665_Chip-Seq_MCF-7_Human1.66600782
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65411915
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.64130277
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61359470
31AR_21909140_ChIP-Seq_LNCAP_Human1.60667323
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60627420
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57086920
34* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55774564
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53437336
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53253874
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53029783
38MYB_26560356_Chip-Seq_TH2_Human1.53004847
39MYB_26560356_Chip-Seq_TH1_Human1.45065023
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42894710
41* KDM2B_26808549_Chip-Seq_DND41_Human1.40777627
42SCL_19346495_ChIP-Seq_HPC-7_Human1.37112044
43KDM5A_27292631_Chip-Seq_BREAST_Human1.35418451
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.35372299
45KDM2B_26808549_Chip-Seq_JURKAT_Human1.34572189
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32949519
47VDR_24763502_ChIP-Seq_THP-1_Human1.31196591
48* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30538255
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29910407
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29509583
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28725402
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26660063
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.26597856
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25440164
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24896076
56CLOCK_20551151_ChIP-Seq_293T_Human1.24458346
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23476539
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23406672
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23077593
60* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22929790
61SPI1_23547873_ChIP-Seq_NB4_Human1.22792347
62* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21870494
63VDR_23849224_ChIP-Seq_CD4+_Human1.21828729
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21406559
65* FOXP3_21729870_ChIP-Seq_TREG_Human1.21364842
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20931434
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20684524
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20595320
69* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20592734
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19129558
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.18312082
72* P68_20966046_ChIP-Seq_HELA_Human1.17745214
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17480073
74* MAF_26560356_Chip-Seq_TH2_Human1.17232640
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17164459
76* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16535778
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16498944
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16083966
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.15647718
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15364956
81TFEB_21752829_ChIP-Seq_HELA_Human1.14941782
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13881022
83NCOR1_26117541_ChIP-Seq_K562_Human1.13514626
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12584622
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12511831
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12012314
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11962596
88GABP_19822575_ChIP-Seq_HepG2_Human1.11778358
89KDM2B_26808549_Chip-Seq_K562_Human1.10873929
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.10456020
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10203148
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09815448
93ZNF263_19887448_ChIP-Seq_K562_Human1.09016030
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07358717
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07112836
96* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06316544
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06228799
98TTF2_22483619_ChIP-Seq_HELA_Human1.05286685
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05191348
100* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05117977
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05028580
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.04920313
103* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04516278
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04021970
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03920537
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03849466
107* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02673019
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02374201
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01690534
110* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00777266
111* ATF3_27146783_Chip-Seq_COLON_Human0.99998370
112DCP1A_22483619_ChIP-Seq_HELA_Human0.99801127
113TP53_22127205_ChIP-Seq_IMR90_Human0.99508905
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99280434
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98286045
116* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97644757
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97638497
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97462635
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97099843
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96579802
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96047795
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95321799
123* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92411893
124* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92054206
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91406867
126* CHD1_26751641_Chip-Seq_LNCaP_Human0.90712155
127* TP63_19390658_ChIP-ChIP_HaCaT_Human0.90178027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps2.84172243
2MP0003693_abnormal_embryo_hatching2.69966494
3MP0005451_abnormal_body_composition2.56343308
4MP0003705_abnormal_hypodermis_morpholog2.54539676
5MP0003111_abnormal_nucleus_morphology2.52440011
6MP0002396_abnormal_hematopoietic_system2.49814229
7MP0010094_abnormal_chromosome_stability2.46185156
8MP0003077_abnormal_cell_cycle2.38999653
9MP0004957_abnormal_blastocyst_morpholog2.32208509
10MP0003763_abnormal_thymus_physiology2.14908510
11MP0005076_abnormal_cell_differentiation2.11086328
12MP0003300_gastrointestinal_ulcer2.09892112
13MP0004808_abnormal_hematopoietic_stem2.06055591
14MP0000685_abnormal_immune_system1.97207472
15MP0009278_abnormal_bone_marrow1.96870974
16MP0002009_preneoplasia1.96139025
17MP0010307_abnormal_tumor_latency1.94719315
18MP0008007_abnormal_cellular_replicative1.93595722
19MP0006054_spinal_hemorrhage1.87157145
20MP0001348_abnormal_lacrimal_gland1.85710377
21* MP0002398_abnormal_bone_marrow1.77519037
22MP0001730_embryonic_growth_arrest1.74803980
23MP0003303_peritoneal_inflammation1.73048652
24MP0000350_abnormal_cell_proliferation1.72754161
25MP0001835_abnormal_antigen_presentation1.69904319
26MP0001800_abnormal_humoral_immune1.69348470
27MP0003566_abnormal_cell_adhesion1.68584117
28MP0000703_abnormal_thymus_morphology1.66020360
29MP0008057_abnormal_DNA_replication1.64549530
30MP0009333_abnormal_splenocyte_physiolog1.63585752
31MP0001545_abnormal_hematopoietic_system1.61387692
32MP0005397_hematopoietic_system_phenotyp1.61387692
33MP0000490_abnormal_crypts_of1.57049714
34MP0002722_abnormal_immune_system1.56828933
35MP0002166_altered_tumor_susceptibility1.55596066
36MP0002796_impaired_skin_barrier1.50901651
37MP0000689_abnormal_spleen_morphology1.48493644
38MP0005023_abnormal_wound_healing1.44008783
39MP0002452_abnormal_antigen_presenting1.42638057
40MP0005501_abnormal_skin_physiology1.40568220
41MP0010234_abnormal_vibrissa_follicle1.36543315
42* MP0000716_abnormal_immune_system1.36437692
43MP0000465_gastrointestinal_hemorrhage1.35912043
44* MP0002420_abnormal_adaptive_immunity1.34197363
45MP0002019_abnormal_tumor_incidence1.33494342
46* MP0001819_abnormal_immune_cell1.32064745
47* MP0002429_abnormal_blood_cell1.31904370
48MP0003436_decreased_susceptibility_to1.31861976
49MP0005671_abnormal_response_to1.31356377
50MP0005380_embryogenesis_phenotype1.30720903
51MP0001672_abnormal_embryogenesis/_devel1.30720903
52MP0000678_abnormal_parathyroid_gland1.30056102
53MP0003984_embryonic_growth_retardation1.29741876
54MP0002088_abnormal_embryonic_growth/wei1.28912006
55MP0002086_abnormal_extraembryonic_tissu1.28174241
56MP0001790_abnormal_immune_system1.27564743
57MP0005387_immune_system_phenotype1.27564743
58MP0004197_abnormal_fetal_growth/weight/1.25932299
59* MP0004947_skin_inflammation1.25690586
60MP0002405_respiratory_system_inflammati1.25315342
61MP0001697_abnormal_embryo_size1.25151818
62MP0000858_altered_metastatic_potential1.24933596
63MP0010155_abnormal_intestine_physiology1.24142813
64* MP0002723_abnormal_immune_serum1.23576595
65MP0001849_ear_inflammation1.23426153
66MP0001873_stomach_inflammation1.22389103
67* MP0002080_prenatal_lethality1.20760447
68MP0000733_abnormal_muscle_development1.20514814
69MP0005409_darkened_coat_color1.15241831
70MP0004381_abnormal_hair_follicle1.14082335
71MP0005058_abnormal_lysosome_morphology1.12187501
72MP0002006_tumorigenesis1.11571497
73MP0002084_abnormal_developmental_patter1.08683521
74MP0005464_abnormal_platelet_physiology1.08188300
75MP0002085_abnormal_embryonic_tissue1.07469358
76MP0004233_abnormal_muscle_weight1.07169716
77MP0001915_intracranial_hemorrhage1.06953957
78MP0008058_abnormal_DNA_repair1.06915129
79MP0000537_abnormal_urethra_morphology1.06077617
80* MP0001216_abnormal_epidermal_layer1.06030618
81MP0000313_abnormal_cell_death1.05612309
82* MP0005000_abnormal_immune_tolerance1.05514138
83MP0000003_abnormal_adipose_tissue1.04945608
84MP0008438_abnormal_cutaneous_collagen1.04370457
85MP0005025_abnormal_response_to1.02475379
86MP0008260_abnormal_autophagy1.00461123
87MP0003123_paternal_imprinting0.99797217
88MP0001853_heart_inflammation0.99460871
89MP0008932_abnormal_embryonic_tissue0.99066560
90MP0002089_abnormal_postnatal_growth/wei0.96196012
91MP0003567_abnormal_fetal_cardiomyocyte0.95850940
92MP0001661_extended_life_span0.94931866
93MP0005666_abnormal_adipose_tissue0.94626507
94* MP0009931_abnormal_skin_appearance0.94337694
95MP0004858_abnormal_nervous_system0.92987454
96MP0004185_abnormal_adipocyte_glucose0.92494256
97MP0003448_altered_tumor_morphology0.92469471
98MP0009053_abnormal_anal_canal0.89833587
99MP0010030_abnormal_orbit_morphology0.89410056
100MP0003191_abnormal_cellular_cholesterol0.87503100
101MP0003453_abnormal_keratinocyte_physiol0.86722854
102MP0000477_abnormal_intestine_morphology0.86591757
103MP0009840_abnormal_foam_cell0.86434678
104MP0005623_abnormal_meninges_morphology0.86236582
105MP0002098_abnormal_vibrissa_morphology0.85479306
106MP0009785_altered_susceptibility_to0.85449063
107MP0008961_abnormal_basal_metabolism0.84582614
108MP0000467_abnormal_esophagus_morphology0.84515691
109MP0005375_adipose_tissue_phenotype0.84336899
110MP0002877_abnormal_melanocyte_morpholog0.83517263
111* MP0001845_abnormal_inflammatory_respons0.80941814
112MP0002419_abnormal_innate_immunity0.77152251
113MP0003091_abnormal_cell_migration0.76923917
114MP0004264_abnormal_extraembryonic_tissu0.76865652
115MP0005621_abnormal_cell_physiology0.76731908
116MP0003866_abnormal_defecation0.76579871
117MP0002060_abnormal_skin_morphology0.75508068
118MP0003786_premature_aging0.75400175
119MP0002925_abnormal_cardiovascular_devel0.72847267
120MP0003279_aneurysm0.71942956
121MP0002933_joint_inflammation0.71533596
122MP0001243_abnormal_dermal_layer0.71373226
123MP0009672_abnormal_birth_weight0.70912388

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.00010557
2Abnormality of the fingertips (HP:0001211)2.79157091
3Selective tooth agenesis (HP:0001592)2.79023587
4Chronic otitis media (HP:0000389)2.74516762
5Recurrent viral infections (HP:0004429)2.73272785
6Ankyloglossia (HP:0010296)2.67990422
7Abnormality of oral frenula (HP:0000190)2.65030630
8Increased density of long bones (HP:0006392)2.64867002
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56753365
10Short 4th metacarpal (HP:0010044)2.56753365
11T lymphocytopenia (HP:0005403)2.52378078
12IgM deficiency (HP:0002850)2.50521668
13Recurrent bronchitis (HP:0002837)2.49712061
14Cerebral aneurysm (HP:0004944)2.48798390
15Thrombocytosis (HP:0001894)2.46706412
16Cellulitis (HP:0100658)2.43725961
17Reticulocytopenia (HP:0001896)2.40842371
18Broad face (HP:0000283)2.40737443
19Asymmetry of the thorax (HP:0001555)2.40547558
20Protrusio acetabuli (HP:0003179)2.39629039
21Ependymoma (HP:0002888)2.38399209
22Nasal polyposis (HP:0100582)2.33528366
23Abnormality of T cell number (HP:0011839)2.33207508
24Insomnia (HP:0100785)2.31357028
25Ulnar bowing (HP:0003031)2.31308378
26Abnormality of T cells (HP:0002843)2.28720902
27Basal cell carcinoma (HP:0002671)2.27879066
28Deviation of the thumb (HP:0009603)2.26840139
29Increased nuchal translucency (HP:0010880)2.26628498
30Proximal placement of thumb (HP:0009623)2.26035167
31Disproportionate tall stature (HP:0001519)2.24774833
32Eczematoid dermatitis (HP:0000976)2.23012910
33Papilloma (HP:0012740)2.19539274
34Verrucae (HP:0200043)2.19539274
35Panhypogammaglobulinemia (HP:0003139)2.17476747
36Long palpebral fissure (HP:0000637)2.15070766
37Gastrointestinal inflammation (HP:0004386)2.14683018
38Abnormality of the distal phalanges of the toes (HP:0010182)2.12892716
39Abnormality of the nasal mucosa (HP:0000433)2.12221232
40Recurrent fungal infections (HP:0002841)2.10850730
41Bicuspid aortic valve (HP:0001647)2.09439307
42Ridged nail (HP:0001807)2.07968969
43Ankle contracture (HP:0006466)2.07503191
44Abnormality of the calcaneus (HP:0008364)2.06641702
45Achilles tendon contracture (HP:0001771)2.06465320
46Flat acetabular roof (HP:0003180)2.04798272
47High pitched voice (HP:0001620)2.04498181
48Long eyelashes (HP:0000527)2.03721631
49Viral hepatitis (HP:0006562)2.01366850
50Prominent nose (HP:0000448)2.00028606
51Elevated erythrocyte sedimentation rate (HP:0003565)1.99323684
52Deep palmar crease (HP:0006191)1.99063598
53Inflammation of the large intestine (HP:0002037)1.98765445
54Colitis (HP:0002583)1.97952601
55Gastrointestinal stroma tumor (HP:0100723)1.97692087
56Renal duplication (HP:0000075)1.97165552
57Dysmetric saccades (HP:0000641)1.97063924
58Pustule (HP:0200039)1.96894649
59Abnormal delayed hypersensitivity skin test (HP:0002963)1.95976435
60Spinal cord lesions (HP:0100561)1.95203078
61Syringomyelia (HP:0003396)1.95203078
62Abnormality of T cell physiology (HP:0011840)1.94972140
63Squamous cell carcinoma (HP:0002860)1.94729745
64B lymphocytopenia (HP:0010976)1.93632623
65Abnormality of B cell number (HP:0010975)1.93632623
66Abnormality of the 4th metacarpal (HP:0010012)1.93308843
67Distal lower limb amyotrophy (HP:0008944)1.90988659
68Reticulocytosis (HP:0001923)1.89849363
69Abnormality of nail color (HP:0100643)1.89126357
70Abnormality of the peritoneum (HP:0002585)1.88608035
71Hematochezia (HP:0002573)1.88044318
72Aortic aneurysm (HP:0004942)1.86131522
73Cutaneous melanoma (HP:0012056)1.85522056
74Abnormal platelet volume (HP:0011876)1.84676978
75Agammaglobulinemia (HP:0004432)1.84402623
76Patellar dislocation (HP:0002999)1.84341500
77Thick nail (HP:0001805)1.83577252
78Amaurosis fugax (HP:0100576)1.83556199
79Osteolytic defects of the hand bones (HP:0009699)1.83367118
80Osteolytic defects of the phalanges of the hand (HP:0009771)1.83367118
81Thin bony cortex (HP:0002753)1.82624408
82Dilatation of the ascending aorta (HP:0005111)1.82469667
83Shallow orbits (HP:0000586)1.82361733
84Renovascular hypertension (HP:0100817)1.81451957
85Cutis marmorata (HP:0000965)1.81404090
86Vertebral compression fractures (HP:0002953)1.81317983
87Trismus (HP:0000211)1.81145030
88Abnormality of cells of the erythroid lineage (HP:0012130)1.80094549
89Sparse lateral eyebrow (HP:0005338)1.79564669
90Colon cancer (HP:0003003)1.76689412
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.76320131
92Elfin facies (HP:0004428)1.76272862
93Hypertensive crisis (HP:0100735)1.75941993
94Pointed chin (HP:0000307)1.75549260
95Bowel diverticulosis (HP:0005222)1.75472346
96Abnormality of cells of the lymphoid lineage (HP:0012140)1.75411761
97Dislocated radial head (HP:0003083)1.74177453
98Meningitis (HP:0001287)1.74045367
99Abnormality of the thoracic spine (HP:0100711)1.73822765
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73085755
101Centrally nucleated skeletal muscle fibers (HP:0003687)1.72974681
102Progressive muscle weakness (HP:0003323)1.72453492
103Abnormal number of erythroid precursors (HP:0012131)1.71151245
104IgA deficiency (HP:0002720)1.71096976
105Relative macrocephaly (HP:0004482)1.71017841
106Persistence of primary teeth (HP:0006335)1.70713540
107Polygenic inheritance (HP:0010982)1.70219197
108Lymphopenia (HP:0001888)1.70172992
109Interstitial pulmonary disease (HP:0006530)1.70038673
110Overriding aorta (HP:0002623)1.69393371
111Biconcave vertebral bodies (HP:0004586)1.69270046
112Spontaneous hematomas (HP:0007420)1.68955022
113Abnormality of the Achilles tendon (HP:0005109)1.68841974
114High anterior hairline (HP:0009890)1.68829126
115Entropion (HP:0000621)1.68688255
116Radial bowing (HP:0002986)1.68667554
117Combined immunodeficiency (HP:0005387)1.68202310
118Multiple enchondromatosis (HP:0005701)1.68069950
119Emphysema (HP:0002097)1.67868558
120Rectal prolapse (HP:0002035)1.67772609
121Fatigue (HP:0012378)1.67547338
122Increased mean platelet volume (HP:0011877)1.66159824
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65650953
124Aplasia/Hypoplasia of the thymus (HP:0010515)1.65547667
125Broad palm (HP:0001169)1.65517497
126Genu recurvatum (HP:0002816)1.65118384
127Skin tags (HP:0010609)1.65070080
128Micronodular cirrhosis (HP:0001413)1.64612709
129Bowed forearm bones (HP:0003956)1.64448469
130Bowing of the arm (HP:0006488)1.64448469
131Medulloblastoma (HP:0002885)1.63809376
132Mitral valve prolapse (HP:0001634)1.63623868
133Abnormality of the radial head (HP:0003995)1.63228475
134Abnormality of the columella (HP:0009929)1.62682414
135Pseudobulbar signs (HP:0002200)1.62641049
136Astrocytoma (HP:0009592)1.62443123
137Abnormality of the astrocytes (HP:0100707)1.62443123
138Lymphoma (HP:0002665)1.62400946
139Increased IgE level (HP:0003212)1.60764990
140Progressive external ophthalmoplegia (HP:0000590)1.60526542
141Premature rupture of membranes (HP:0001788)1.59370167
142Autoimmune hemolytic anemia (HP:0001890)1.59361171
143Poikiloderma (HP:0001029)1.58858499
144Orthostatic hypotension (HP:0001278)1.58648708
145Malignant gastrointestinal tract tumors (HP:0006749)1.58533618
146Gastrointestinal carcinoma (HP:0002672)1.58533618
147Milia (HP:0001056)1.58399346
148Increased connective tissue (HP:0009025)1.58089817
149Hallux valgus (HP:0001822)1.57882782
150Abnormality of the anterior horn cell (HP:0006802)1.57571314
151Degeneration of anterior horn cells (HP:0002398)1.57571314
152Abnormality of reticulocytes (HP:0004312)1.57443775
153Mediastinal lymphadenopathy (HP:0100721)1.56403187
154Neoplasm of the pancreas (HP:0002894)1.56078360
155Subacute progressive viral hepatitis (HP:0006572)1.55961755
156Heterotopia (HP:0002282)1.55234775
157Septate vagina (HP:0001153)1.54644518
158Hemorrhage of the eye (HP:0011885)1.53457557
159Fragile skin (HP:0001030)1.50975927
160Truncus arteriosus (HP:0001660)1.50445971
161Back pain (HP:0003418)1.49670912
162Abnormality of the gastric mucosa (HP:0004295)1.48093490
163Hepatitis (HP:0012115)1.47993830
164Seborrheic dermatitis (HP:0001051)1.47655888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.28813270
2EEF2K4.16264641
3PRPF4B3.45626836
4TRIB33.33355023
5MAP3K103.19942436
6PKN22.89990403
7MAP4K12.83555970
8IRAK32.36705775
9CDK122.35923845
10STK102.30233195
11CDC72.29680415
12NEK22.20084115
13ERN11.95591113
14RPS6KB21.84552698
15LRRK21.83763690
16SCYL21.80114861
17TESK21.79104832
18RPS6KA41.63566920
19MAP3K141.53295358
20JAK31.53221411
21MAP3K131.52274913
22PASK1.49971190
23WEE11.49911562
24FLT31.49055961
25TTN1.48430690
26CDK41.41198875
27PTK61.40750263
28BUB11.39835662
29ZAP701.37133881
30GRK61.36887563
31PAK41.34788294
32FGFR41.32796678
33RIPK41.31901649
34TYK21.28074147
35MAP3K81.20314288
36BRSK21.19360136
37TGFBR11.19020688
38KSR21.15883438
39BLK1.12820752
40MAP2K21.10944513
41BTK1.10732928
42TAOK21.08997364
43IRAK41.05808943
44SIK11.04989819
45CSF1R1.03930886
46CDK61.02770994
47ALK1.01625984
48ATR0.98873447
49KDR0.98161704
50MAP2K30.97444898
51TSSK60.97039962
52PIM10.96660642
53CDK70.94679013
54ITK0.93098419
55NEK10.91982023
56PDGFRA0.89675900
57MTOR0.89668869
58MAPKAPK30.88086873
59STK40.87767076
60KIT0.87079148
61TBK10.85713265
62FGFR30.85378928
63AURKB0.83816589
64RIPK10.83620732
65DYRK30.82096759
66PAK20.82052849
67ACVR1B0.81355691
68CDK80.80387733
69CHEK10.79587521
70EIF2AK10.77746515
71BRD40.77242615
72NME20.76597275
73TTK0.74547942
74EPHA30.74118906
75TGFBR20.73985785
76ARAF0.72808485
77STK30.72766787
78MARK30.71423008
79RPS6KL10.71360991
80RPS6KC10.71360991
81EPHA20.69799280
82EPHB10.68933432
83MAP3K10.68553669
84RPS6KA20.67871576
85HIPK20.67533785
86CSK0.67510688
87CDK90.66764562
88SIK30.65376289
89PLK10.65149515
90TESK10.64560548
91SIK20.64088644
92SRPK10.63422752
93PRKD20.61953258
94CHUK0.61431098
95TAOK10.60588097
96HCK0.60414856
97AURKA0.59904636
98RAF10.59774855
99MST1R0.58439516
100TXK0.58047449
101MAP3K110.57188352
102BRSK10.57147242
103FES0.57076507
104LCK0.56929491
105JAK10.56134426
106MAPK110.56007073
107LATS10.54998560
108PIM20.54404900
109SYK0.54008807
110TYRO30.53176231
111RPS6KA60.52228819
112CLK10.52196216
113FGFR10.50985873
114* CDK20.50925307
115ILK0.50606238
116TLK10.50148749
117RET0.50057721
118BRAF0.49981337
119IRAK20.48367062
120PDGFRB0.47818218
121PDPK10.47777553
122DYRK1B0.47746204
123CDC42BPA0.47055920
124ICK0.46419365
125BMX0.46002718
126CHEK20.45704547
127MARK20.45325567
128MAP3K30.45306808
129JAK20.45072654
130CAMK1D0.44793263
131LATS20.44724793
132ATM0.44563470
133IKBKE0.43589209
134MAPKAPK20.43531422
135TAF10.42419443
136MAP3K70.40556612
137NEK90.40173859
138IKBKB0.40081822
139MAP3K90.39270302
140MELK0.39166711

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.25570457
2Mismatch repair_Homo sapiens_hsa034302.31499478
3Primary immunodeficiency_Homo sapiens_hsa053402.29801164
4Spliceosome_Homo sapiens_hsa030402.29251269
5Cell cycle_Homo sapiens_hsa041102.15894209
6Base excision repair_Homo sapiens_hsa034102.09146023
7One carbon pool by folate_Homo sapiens_hsa006702.07713234
8RNA transport_Homo sapiens_hsa030132.07032278
9Antigen processing and presentation_Homo sapiens_hsa046122.01155346
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83641853
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69266766
12Chronic myeloid leukemia_Homo sapiens_hsa052201.68394573
13p53 signaling pathway_Homo sapiens_hsa041151.60737484
14B cell receptor signaling pathway_Homo sapiens_hsa046621.57543927
15Viral carcinogenesis_Homo sapiens_hsa052031.54408875
16Small cell lung cancer_Homo sapiens_hsa052221.52590910
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49655484
18Ribosome_Homo sapiens_hsa030101.47976189
19Herpes simplex infection_Homo sapiens_hsa051681.46048388
20mRNA surveillance pathway_Homo sapiens_hsa030151.39412164
21Measles_Homo sapiens_hsa051621.34126439
22Nucleotide excision repair_Homo sapiens_hsa034201.33822328
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.33189920
24Acute myeloid leukemia_Homo sapiens_hsa052211.32254992
25HTLV-I infection_Homo sapiens_hsa051661.32198350
26MicroRNAs in cancer_Homo sapiens_hsa052061.28695322
27T cell receptor signaling pathway_Homo sapiens_hsa046601.27223291
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24627298
29Homologous recombination_Homo sapiens_hsa034401.23331858
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21656459
31Other glycan degradation_Homo sapiens_hsa005111.20787768
32Viral myocarditis_Homo sapiens_hsa054161.20722063
33Leishmaniasis_Homo sapiens_hsa051401.20701358
34Non-homologous end-joining_Homo sapiens_hsa034501.20607520
35Epstein-Barr virus infection_Homo sapiens_hsa051691.18643485
36Apoptosis_Homo sapiens_hsa042101.17179590
37Systemic lupus erythematosus_Homo sapiens_hsa053221.17053919
38Glioma_Homo sapiens_hsa052141.16205557
39Hepatitis B_Homo sapiens_hsa051611.13541671
40Notch signaling pathway_Homo sapiens_hsa043301.12116199
41Pancreatic cancer_Homo sapiens_hsa052121.11564078
42Colorectal cancer_Homo sapiens_hsa052101.09819628
43Shigellosis_Homo sapiens_hsa051311.09744221
44Toxoplasmosis_Homo sapiens_hsa051451.09422305
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.08107836
46Osteoclast differentiation_Homo sapiens_hsa043801.04793794
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04692110
48Pentose phosphate pathway_Homo sapiens_hsa000301.04049109
49ErbB signaling pathway_Homo sapiens_hsa040121.03015203
50RNA degradation_Homo sapiens_hsa030181.02753027
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01127903
52Non-small cell lung cancer_Homo sapiens_hsa052231.00197434
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99993581
54Legionellosis_Homo sapiens_hsa051340.98523243
55Hematopoietic cell lineage_Homo sapiens_hsa046400.97341915
56Lysine degradation_Homo sapiens_hsa003100.97158411
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.94905665
58Prion diseases_Homo sapiens_hsa050200.94372825
59mTOR signaling pathway_Homo sapiens_hsa041500.93652230
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93132031
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.92325924
62Alcoholism_Homo sapiens_hsa050340.88998424
63Pyrimidine metabolism_Homo sapiens_hsa002400.88216783
64Proteoglycans in cancer_Homo sapiens_hsa052050.87664640
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86599954
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.85930263
67Fanconi anemia pathway_Homo sapiens_hsa034600.84773735
68Thyroid cancer_Homo sapiens_hsa052160.84379814
69Bladder cancer_Homo sapiens_hsa052190.84326377
70Influenza A_Homo sapiens_hsa051640.83724380
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83025578
72Adherens junction_Homo sapiens_hsa045200.82615506
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80934819
74Selenocompound metabolism_Homo sapiens_hsa004500.76032692
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75410738
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75186185
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.74976892
78Graft-versus-host disease_Homo sapiens_hsa053320.74632671
79Endometrial cancer_Homo sapiens_hsa052130.73330046
80Allograft rejection_Homo sapiens_hsa053300.73100212
81Biosynthesis of amino acids_Homo sapiens_hsa012300.72554719
82VEGF signaling pathway_Homo sapiens_hsa043700.72097624
83Insulin signaling pathway_Homo sapiens_hsa049100.71342517
84Autoimmune thyroid disease_Homo sapiens_hsa053200.70587225
85Focal adhesion_Homo sapiens_hsa045100.70506065
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.69776802
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69492682
88Inositol phosphate metabolism_Homo sapiens_hsa005620.69092699
89Platelet activation_Homo sapiens_hsa046110.67771572
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.67507253
91Choline metabolism in cancer_Homo sapiens_hsa052310.66502326
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66323556
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.65728136
94HIF-1 signaling pathway_Homo sapiens_hsa040660.65087346
95Prostate cancer_Homo sapiens_hsa052150.64222009
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64144686
97TNF signaling pathway_Homo sapiens_hsa046680.64135801
98Salmonella infection_Homo sapiens_hsa051320.61335150
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60549545
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59988305
101Pathways in cancer_Homo sapiens_hsa052000.58822967
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.58668654
103Endocytosis_Homo sapiens_hsa041440.58282523
104Melanoma_Homo sapiens_hsa052180.58226114
105Chemokine signaling pathway_Homo sapiens_hsa040620.57950631
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57785340
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57461168
108Estrogen signaling pathway_Homo sapiens_hsa049150.56820119
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56057123
110RNA polymerase_Homo sapiens_hsa030200.55926033
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55918743
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55616731
113Prolactin signaling pathway_Homo sapiens_hsa049170.54956277
114Sulfur relay system_Homo sapiens_hsa041220.54466322
115N-Glycan biosynthesis_Homo sapiens_hsa005100.54431053
116Insulin resistance_Homo sapiens_hsa049310.54157590
117GnRH signaling pathway_Homo sapiens_hsa049120.53875382
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53013390
119Hippo signaling pathway_Homo sapiens_hsa043900.52296266
120FoxO signaling pathway_Homo sapiens_hsa040680.49549906
121Renal cell carcinoma_Homo sapiens_hsa052110.48084171
122TGF-beta signaling pathway_Homo sapiens_hsa043500.46992746
123Hepatitis C_Homo sapiens_hsa051600.46971551
124Tuberculosis_Homo sapiens_hsa051520.46536403

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