MTAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.62833319
2folic acid-containing compound biosynthetic process (GO:0009396)4.54891002
3ribosomal small subunit assembly (GO:0000028)4.38062379
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.34463736
5protein localization to kinetochore (GO:0034501)4.18166727
6formation of translation preinitiation complex (GO:0001731)4.17513539
7viral transcription (GO:0019083)4.16952223
8translational termination (GO:0006415)4.15360039
9DNA strand elongation involved in DNA replication (GO:0006271)4.13938695
10DNA double-strand break processing (GO:0000729)4.01877754
11maturation of SSU-rRNA (GO:0030490)3.97986189
12DNA strand elongation (GO:0022616)3.93153765
13DNA replication initiation (GO:0006270)3.92592220
14IMP biosynthetic process (GO:0006188)3.86415826
15regulation of centriole replication (GO:0046599)3.80799647
16mitotic nuclear envelope disassembly (GO:0007077)3.80411205
17translational elongation (GO:0006414)3.80247093
18regulation of posttranscriptional gene silencing (GO:0060147)3.79166450
19regulation of gene silencing by miRNA (GO:0060964)3.79166450
20regulation of gene silencing by RNA (GO:0060966)3.79166450
21nuclear pore complex assembly (GO:0051292)3.78154765
22nuclear pore organization (GO:0006999)3.77286009
23telomere maintenance via semi-conservative replication (GO:0032201)3.75709076
24translational initiation (GO:0006413)3.69802889
25regulation of nuclear cell cycle DNA replication (GO:0033262)3.69047221
26somatic hypermutation of immunoglobulin genes (GO:0016446)3.64465291
27somatic diversification of immune receptors via somatic mutation (GO:0002566)3.64465291
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.61049185
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.61049185
30regulation of translation, ncRNA-mediated (GO:0045974)3.61049185
31ribosomal small subunit biogenesis (GO:0042274)3.60912482
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60488496
33histone exchange (GO:0043486)3.59243973
34replication fork processing (GO:0031297)3.58975609
35nuclear envelope disassembly (GO:0051081)3.54898562
36membrane disassembly (GO:0030397)3.54898562
37IMP metabolic process (GO:0046040)3.54476775
38ribosomal large subunit biogenesis (GO:0042273)3.53621191
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.52285659
40protein targeting to ER (GO:0045047)3.49583847
41cotranslational protein targeting to membrane (GO:0006613)3.48220187
42telomere maintenance via recombination (GO:0000722)3.46691510
43protein localization to chromosome, centromeric region (GO:0071459)3.44877069
44response to X-ray (GO:0010165)3.43098393
45nucleobase biosynthetic process (GO:0046112)3.41628888
46negative regulation of DNA-dependent DNA replication (GO:2000104)3.41146237
47non-recombinational repair (GO:0000726)3.40126564
48double-strand break repair via nonhomologous end joining (GO:0006303)3.40126564
49mitotic recombination (GO:0006312)3.39182559
50ribosome assembly (GO:0042255)3.37771554
51ribonucleoprotein complex biogenesis (GO:0022613)3.37340317
52regulation of hippo signaling (GO:0035330)3.33706182
53DNA replication-dependent nucleosome assembly (GO:0006335)3.32851820
54DNA replication-dependent nucleosome organization (GO:0034723)3.32851820
55mitotic metaphase plate congression (GO:0007080)3.32525979
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32041583
57ribosome biogenesis (GO:0042254)3.28545036
58protein localization to endoplasmic reticulum (GO:0070972)3.27287182
59regulation of centrosome duplication (GO:0010824)3.26169694
60viral life cycle (GO:0019058)3.25544133
61cellular protein complex disassembly (GO:0043624)3.23247564
62regulation of DNA endoreduplication (GO:0032875)3.22973921
63DNA replication checkpoint (GO:0000076)3.19234342
64regulation of spindle organization (GO:0090224)3.17188872
65telomere maintenance via telomere lengthening (GO:0010833)3.12758923
66CENP-A containing nucleosome assembly (GO:0034080)3.10332307
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10149809
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10037420
69meiotic chromosome segregation (GO:0045132)3.08503080
70kinetochore organization (GO:0051383)3.08108136
71replicative senescence (GO:0090399)3.07944383
72chromatin remodeling at centromere (GO:0031055)3.06114372
73mitotic spindle checkpoint (GO:0071174)3.04818851
74DNA-dependent DNA replication (GO:0006261)3.03669572
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02480751
76purine nucleobase biosynthetic process (GO:0009113)3.01319883
77DNA duplex unwinding (GO:0032508)3.01060553
78metaphase plate congression (GO:0051310)2.99802051
79DNA geometric change (GO:0032392)2.98718798
80histone-serine phosphorylation (GO:0035404)2.97495531
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97032019
82regulation of mitotic spindle checkpoint (GO:1903504)2.97032019
83heterochromatin organization (GO:0070828)2.96322515
84pteridine-containing compound biosynthetic process (GO:0042559)2.93906729
85double-strand break repair via homologous recombination (GO:0000724)2.92532477
86rRNA processing (GO:0006364)2.91775469
87regulation of mitotic spindle organization (GO:0060236)2.91673818
88protein complex disassembly (GO:0043241)2.90732511
89recombinational repair (GO:0000725)2.90417741
90mitotic chromosome condensation (GO:0007076)2.90319026
91regulation of helicase activity (GO:0051095)2.90227746
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88024654
93tetrahydrofolate metabolic process (GO:0046653)2.87963333
94DNA deamination (GO:0045006)2.86308568
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86235111
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85362946
97translesion synthesis (GO:0019985)2.84909560
98mitochondrial RNA metabolic process (GO:0000959)2.84872229
99mitotic sister chromatid segregation (GO:0000070)2.84345399
100sister chromatid segregation (GO:0000819)2.83243393
101nucleotide-excision repair, DNA gap filling (GO:0006297)2.82073861
102DNA replication-independent nucleosome organization (GO:0034724)2.80995947
103DNA replication-independent nucleosome assembly (GO:0006336)2.80995947
104maturation of 5.8S rRNA (GO:0000460)2.80727567
105pore complex assembly (GO:0046931)2.80356009
106nuclear-transcribed mRNA catabolic process (GO:0000956)2.80305560
107postreplication repair (GO:0006301)2.80243169
108rRNA metabolic process (GO:0016072)2.79712852
109negative regulation of RNA splicing (GO:0033119)2.77265700
110regulation of translational fidelity (GO:0006450)2.77231438
111establishment of chromosome localization (GO:0051303)2.77049442
112mitotic sister chromatid cohesion (GO:0007064)2.76855463
113nuclear envelope organization (GO:0006998)2.76556332
114DNA damage response, detection of DNA damage (GO:0042769)2.76294419
115regulation of mitotic sister chromatid segregation (GO:0033047)2.75555086
116regulation of sister chromatid segregation (GO:0033045)2.75555086
117regulation of mitotic sister chromatid separation (GO:0010965)2.75555086
118translation (GO:0006412)2.72969222
119macromolecular complex disassembly (GO:0032984)2.72756465
120establishment of integrated proviral latency (GO:0075713)2.71065545
121spliceosomal snRNP assembly (GO:0000387)2.69896240
122DNA catabolic process, exonucleolytic (GO:0000738)2.69485014
123L-serine metabolic process (GO:0006563)2.68843810
124telomere maintenance (GO:0000723)2.67589422
125positive regulation of developmental pigmentation (GO:0048087)2.65823303
126mRNA catabolic process (GO:0006402)2.65611433
127regulation of chromosome segregation (GO:0051983)2.65215243
128UDP-N-acetylglucosamine metabolic process (GO:0006047)2.64953537
129telomere organization (GO:0032200)2.64404607
130G1/S transition of mitotic cell cycle (GO:0000082)2.64163681
131cell cycle G1/S phase transition (GO:0044843)2.64163681
132RNA catabolic process (GO:0006401)2.63033759
133attachment of spindle microtubules to kinetochore (GO:0008608)2.62015223
134pseudouridine synthesis (GO:0001522)2.61184010
135folic acid metabolic process (GO:0046655)2.60617379
136regulation of centrosome cycle (GO:0046605)2.60000703
137negative regulation of DNA repair (GO:0045738)2.58518446
138nucleobase-containing small molecule interconversion (GO:0015949)2.58283465
139regulation of protein heterodimerization activity (GO:0043497)2.57942406
140double-strand break repair (GO:0006302)2.57456557
141regulation of sister chromatid cohesion (GO:0007063)2.57277733
142spindle assembly checkpoint (GO:0071173)2.56126491
143spindle checkpoint (GO:0031577)2.55764073
144regulation of mitotic metaphase/anaphase transition (GO:0030071)2.54760335
145regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.54258323
146mitotic spindle assembly checkpoint (GO:0007094)2.54080404
147negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.53807451
148negative regulation of sister chromatid segregation (GO:0033046)2.53807451
149negative regulation of mitotic sister chromatid separation (GO:2000816)2.53807451
150negative regulation of mitotic sister chromatid segregation (GO:0033048)2.53807451
151negative regulation of chromosome segregation (GO:0051985)2.53695866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.08052107
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.46481756
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.23239158
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88407751
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.86752948
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38020795
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00044410
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94839515
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.83678396
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69434349
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63041776
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54603628
13AR_21909140_ChIP-Seq_LNCAP_Human2.48348589
14EWS_26573619_Chip-Seq_HEK293_Human2.45255181
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44885823
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.43145782
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42807088
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.39207788
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28545995
20XRN2_22483619_ChIP-Seq_HELA_Human2.26172208
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.23747663
22ZNF274_21170338_ChIP-Seq_K562_Hela2.23532408
23FUS_26573619_Chip-Seq_HEK293_Human2.20541112
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12806451
25TAF15_26573619_Chip-Seq_HEK293_Human2.12183354
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08169434
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.07472696
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03842709
29VDR_22108803_ChIP-Seq_LS180_Human2.01296340
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.00103932
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97112949
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96806751
33DCP1A_22483619_ChIP-Seq_HELA_Human1.94975095
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89838675
35* VDR_23849224_ChIP-Seq_CD4+_Human1.86801394
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86647378
37MYC_22102868_ChIP-Seq_BL_Human1.84248049
38IGF1R_20145208_ChIP-Seq_DFB_Human1.84032415
39ELK1_19687146_ChIP-ChIP_HELA_Human1.83165634
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77654533
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76183992
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75454100
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73245368
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73240333
45TTF2_22483619_ChIP-Seq_HELA_Human1.72934117
46FOXP3_21729870_ChIP-Seq_TREG_Human1.71650392
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71077140
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70197392
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70023783
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68419782
51P300_19829295_ChIP-Seq_ESCs_Human1.67815023
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67125531
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67029779
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66448544
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65412152
56GABP_19822575_ChIP-Seq_HepG2_Human1.64892419
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61058665
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59871197
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55846012
60GBX2_23144817_ChIP-Seq_PC3_Human1.51666210
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48961449
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48248963
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43990998
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42228684
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40539991
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37901911
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36588351
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.35930949
69TFEB_21752829_ChIP-Seq_HELA_Human1.35451632
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35161638
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33358263
72IRF1_19129219_ChIP-ChIP_H3396_Human1.33297178
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32767453
74STAT3_23295773_ChIP-Seq_U87_Human1.29349490
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28893982
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25722363
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25620486
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25528293
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24960234
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.24790737
81* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24524025
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24414417
83KDM5A_27292631_Chip-Seq_BREAST_Human1.23967911
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23774386
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23304763
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22964005
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22745573
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22409691
89TP63_17297297_ChIP-ChIP_HaCaT_Human1.21509739
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21382730
91* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19565721
92NANOG_16153702_ChIP-ChIP_HESCs_Human1.19002079
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18562113
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17131608
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.16394579
96CIITA_25753668_ChIP-Seq_RAJI_Human1.14266028
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14168217
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14006588
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.13165385
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13103256
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12911051
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10510133
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10236549
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08079340
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07335793
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.06851724
107ER_23166858_ChIP-Seq_MCF-7_Human1.06784320
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06618297
109TCF4_23295773_ChIP-Seq_U87_Human1.06535035
110VDR_21846776_ChIP-Seq_THP-1_Human1.06050717
111CLOCK_20551151_ChIP-Seq_293T_Human1.05661127
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05385082
113CBP_20019798_ChIP-Seq_JUKART_Human1.05385082
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.04713754
115SOX2_16153702_ChIP-ChIP_HESCs_Human1.04577450
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04569726
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04539004
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03558809
119* SMAD4_21799915_ChIP-Seq_A2780_Human1.03169364
120TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03081652
121* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03012363
122RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02151578
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01219574
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00533342
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.00250710
126* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00022183
127TP53_16413492_ChIP-PET_HCT116_Human0.99153017
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99124403
129FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98956487
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98743933
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97206065
132TCF4_22108803_ChIP-Seq_LS180_Human0.97122634
133CDX2_22108803_ChIP-Seq_LS180_Human0.96868033
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96853602
135BCAT_22108803_ChIP-Seq_LS180_Human0.96099854
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95686193
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95682586
138HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95397286
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95334623
140SPI1_23547873_ChIP-Seq_NB4_Human0.94648117
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.94525632
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94022483
143* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92361974
144ATF3_27146783_Chip-Seq_COLON_Human0.92247754
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91833651
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91294967
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91066418
148MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90223762
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90069430
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89188632
151FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89119602
152PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88928510
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88499264
154TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87934310
155BRD4_25478319_ChIP-Seq_HGPS_Human0.87762541
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.87499677
157TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87418596
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87307844
159POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87307844
160TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86442625
161TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85967671
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85241941
163ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84368984
164MYC_18940864_ChIP-ChIP_HL60_Human0.84296581
165ELK3_25401928_ChIP-Seq_HUVEC_Human0.82876655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.27885780
2MP0004957_abnormal_blastocyst_morpholog3.18963546
3MP0000569_abnormal_digit_pigmentation3.18113252
4MP0010094_abnormal_chromosome_stability2.95549168
5MP0003705_abnormal_hypodermis_morpholog2.91923871
6MP0008438_abnormal_cutaneous_collagen2.87450714
7MP0003890_abnormal_embryonic-extraembry2.87281320
8MP0010352_gastrointestinal_tract_polyps2.85327451
9MP0003077_abnormal_cell_cycle2.73359570
10MP0003111_abnormal_nucleus_morphology2.66400063
11MP0008007_abnormal_cellular_replicative2.62259283
12MP0010030_abnormal_orbit_morphology2.33965503
13MP0003718_maternal_effect2.27916536
14MP0002396_abnormal_hematopoietic_system2.25643007
15MP0008932_abnormal_embryonic_tissue2.09916476
16MP0005023_abnormal_wound_healing1.93284912
17MP0008057_abnormal_DNA_replication1.86139634
18MP0001730_embryonic_growth_arrest1.85816426
19MP0004808_abnormal_hematopoietic_stem1.83445019
20MP0000350_abnormal_cell_proliferation1.82496820
21MP0008877_abnormal_DNA_methylation1.80959333
22MP0006054_spinal_hemorrhage1.76844622
23MP0003806_abnormal_nucleotide_metabolis1.75890675
24MP0009053_abnormal_anal_canal1.73358004
25MP0002877_abnormal_melanocyte_morpholog1.69923456
26MP0003123_paternal_imprinting1.68973602
27MP0003279_aneurysm1.65387382
28MP0010307_abnormal_tumor_latency1.62402056
29MP0000579_abnormal_nail_morphology1.62355680
30MP0008058_abnormal_DNA_repair1.55927122
31MP0000427_abnormal_hair_cycle1.54709481
32MP0006292_abnormal_olfactory_placode1.54506113
33MP0003566_abnormal_cell_adhesion1.50111966
34MP0005275_abnormal_skin_tensile1.49793865
35MP0003119_abnormal_digestive_system1.47935209
36MP0003646_muscle_fatigue1.45905532
37MP0001697_abnormal_embryo_size1.45659320
38MP0006072_abnormal_retinal_apoptosis1.45440807
39MP0002234_abnormal_pharynx_morphology1.45349568
40MP0004197_abnormal_fetal_growth/weight/1.42085723
41MP0005380_embryogenesis_phenotype1.41385308
42MP0001672_abnormal_embryogenesis/_devel1.41385308
43MP0005503_abnormal_tendon_morphology1.41201838
44MP0000490_abnormal_crypts_of1.39565661
45MP0003984_embryonic_growth_retardation1.39217225
46MP0002088_abnormal_embryonic_growth/wei1.36485960
47MP0005076_abnormal_cell_differentiation1.35814513
48MP0000383_abnormal_hair_follicle1.34831737
49MP0002697_abnormal_eye_size1.34046846
50MP0001286_abnormal_eye_development1.31549849
51MP0009379_abnormal_foot_pigmentation1.30958788
52MP0003195_calcinosis1.29920017
53* MP0002080_prenatal_lethality1.28859284
54MP0002086_abnormal_extraembryonic_tissu1.25757833
55MP0010678_abnormal_skin_adnexa1.23030327
56MP0003567_abnormal_fetal_cardiomyocyte1.22780120
57MP0002102_abnormal_ear_morphology1.22560669
58MP0000858_altered_metastatic_potential1.20783019
59MP0002085_abnormal_embryonic_tissue1.20632700
60MP0002084_abnormal_developmental_patter1.19555578
61MP0009333_abnormal_splenocyte_physiolog1.19506686
62MP0002233_abnormal_nose_morphology1.18990501
63MP0000733_abnormal_muscle_development1.18887470
64MP0003136_yellow_coat_color1.18596200
65MP0002019_abnormal_tumor_incidence1.17570948
66MP0001661_extended_life_span1.14874945
67MP0003950_abnormal_plasma_membrane1.14528144
68MP0003786_premature_aging1.13612812
69MP0010368_abnormal_lymphatic_system1.11430248
70MP0005253_abnormal_eye_physiology1.10780642
71MP0001243_abnormal_dermal_layer1.08928480
72MP0000647_abnormal_sebaceous_gland1.08631792
73MP0005397_hematopoietic_system_phenotyp1.08053313
74MP0001545_abnormal_hematopoietic_system1.08053313
75MP0003755_abnormal_palate_morphology1.07662073
76MP0000762_abnormal_tongue_morphology1.03782951
77MP0002160_abnormal_reproductive_system1.02445985
78MP0001293_anophthalmia1.01767918
79MP0005187_abnormal_penis_morphology1.01624873
80MP0005395_other_phenotype1.01552322
81MP0003315_abnormal_perineum_morphology1.01183930
82MP0000313_abnormal_cell_death1.01113032
83MP0001915_intracranial_hemorrhage1.00557539
84MP0005391_vision/eye_phenotype1.00328199
85MP0004133_heterotaxia0.98779128
86MP0000428_abnormal_craniofacial_morphol0.98355493
87MP0006035_abnormal_mitochondrial_morpho0.98240113
88MP0009384_cardiac_valve_regurgitation0.97406685
89MP0000750_abnormal_muscle_regeneration0.97373922
90MP0000537_abnormal_urethra_morphology0.96889923
91MP0005551_abnormal_eye_electrophysiolog0.96080676
92MP0003091_abnormal_cell_migration0.93643589
93MP0009703_decreased_birth_body0.93215809
94MP0009250_abnormal_appendicular_skeleto0.93011202
95MP0005508_abnormal_skeleton_morphology0.92702086
96MP0001958_emphysema0.92693040
97MP0002009_preneoplasia0.92478687
98MP0009672_abnormal_birth_weight0.91538159
99MP0005257_abnormal_intraocular_pressure0.90945332
100MP0004272_abnormal_basement_membrane0.90808965
101MP0002282_abnormal_trachea_morphology0.90210083
102MP0002111_abnormal_tail_morphology0.90043427
103MP0001299_abnormal_eye_distance/0.89926956
104MP0002060_abnormal_skin_morphology0.88998650
105MP0003385_abnormal_body_wall0.88525303
106MP0002254_reproductive_system_inflammat0.87395455
107MP0005171_absent_coat_pigmentation0.86736680
108MP0004233_abnormal_muscle_weight0.86207411
109MP0003186_abnormal_redox_activity0.85742526
110MP0003942_abnormal_urinary_system0.85036744
111MP0002210_abnormal_sex_determination0.84948441
112MP0000358_abnormal_cell_content/0.84226884
113MP0000703_abnormal_thymus_morphology0.83659899
114MP0005623_abnormal_meninges_morphology0.82973379
115MP0002751_abnormal_autonomic_nervous0.82423016
116MP0002932_abnormal_joint_morphology0.82404616
117MP0001188_hyperpigmentation0.81519702
118MP0003937_abnormal_limbs/digits/tail_de0.81088497
119MP0003763_abnormal_thymus_physiology0.80187276
120MP0003935_abnormal_craniofacial_develop0.79868274
121MP0009697_abnormal_copulation0.79505471
122MP0003861_abnormal_nervous_system0.79373634
123MP0002938_white_spotting0.77268652
124MP0001929_abnormal_gametogenesis0.76731496
125MP0009278_abnormal_bone_marrow0.76302431
126MP0002092_abnormal_eye_morphology0.75827699
127MP0005174_abnormal_tail_pigmentation0.74902448
128MP0002722_abnormal_immune_system0.74083578
129MP0001145_abnormal_male_reproductive0.73619330
130MP0002933_joint_inflammation0.72857704
131MP0000653_abnormal_sex_gland0.72189184
132MP0002090_abnormal_vision0.72127357
133MP0002089_abnormal_postnatal_growth/wei0.72126979
134MP0002398_abnormal_bone_marrow0.71942033
135MP0000049_abnormal_middle_ear0.70810941
136MP0003300_gastrointestinal_ulcer0.70802400
137MP0002113_abnormal_skeleton_development0.70794437
138MP0004215_abnormal_myocardial_fiber0.70470122
139MP0003115_abnormal_respiratory_system0.70160322
140MP0000689_abnormal_spleen_morphology0.69643059
141MP0002925_abnormal_cardiovascular_devel0.68994943
142MP0003252_abnormal_bile_duct0.68839942
143MP0003941_abnormal_skin_development0.67484426
144MP0000432_abnormal_head_morphology0.67481035
145MP0003943_abnormal_hepatobiliary_system0.67156659
146MP0000767_abnormal_smooth_muscle0.66244690
147MP0003448_altered_tumor_morphology0.66048022
148MP0001853_heart_inflammation0.66042928
149MP0005621_abnormal_cell_physiology0.65871959
150MP0004084_abnormal_cardiac_muscle0.65600250
151MP0002128_abnormal_blood_circulation0.65407191
152MP0008961_abnormal_basal_metabolism0.65236604
153MP0003436_decreased_susceptibility_to0.64455994
154MP0001324_abnormal_eye_pigmentation0.63962010
155MP0002109_abnormal_limb_morphology0.62771024
156MP0003121_genomic_imprinting0.62024023
157MP0005389_reproductive_system_phenotype0.61983449

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.31151835
2Premature rupture of membranes (HP:0001788)4.12663875
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.97579411
4Reticulocytopenia (HP:0001896)3.29999458
5Selective tooth agenesis (HP:0001592)3.19132229
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.05613027
7Ankle contracture (HP:0006466)3.02839645
8Volvulus (HP:0002580)2.93571240
9Abnormality of the ileum (HP:0001549)2.92033026
10Colon cancer (HP:0003003)2.88317207
11Cervical subluxation (HP:0003308)2.84217189
12Aplastic anemia (HP:0001915)2.81566871
13Pancreatic cysts (HP:0001737)2.76247235
14Birth length less than 3rd percentile (HP:0003561)2.70719130
15Abnormality of the preputium (HP:0100587)2.69249547
16Biconcave vertebral bodies (HP:0004586)2.66632309
17Syringomyelia (HP:0003396)2.63226590
18Spinal cord lesions (HP:0100561)2.63226590
19Thrombocytosis (HP:0001894)2.62639752
20Abnormality of the labia minora (HP:0012880)2.56503558
21Pancreatic fibrosis (HP:0100732)2.54921509
22True hermaphroditism (HP:0010459)2.53317510
23Abnormality of cells of the erythroid lineage (HP:0012130)2.52954584
24Abnormality of the anterior horn cell (HP:0006802)2.52387004
25Degeneration of anterior horn cells (HP:0002398)2.52387004
26Trismus (HP:0000211)2.51471012
27Vertebral compression fractures (HP:0002953)2.51347207
28Glioma (HP:0009733)2.50258777
29Small intestinal stenosis (HP:0012848)2.49755921
30Duodenal stenosis (HP:0100867)2.49755921
31Absent radius (HP:0003974)2.47854601
32Aplasia/Hypoplasia of the sternum (HP:0006714)2.47469485
33Protruding tongue (HP:0010808)2.45635024
34Deviation of the thumb (HP:0009603)2.44921944
35Hypoplasia of the pons (HP:0012110)2.43172044
36Abnormality of alanine metabolism (HP:0010916)2.42928923
37Hyperalaninemia (HP:0003348)2.42928923
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42928923
39Abnormality of the calcaneus (HP:0008364)2.42770197
40Sloping forehead (HP:0000340)2.40696648
41Abnormality of the pons (HP:0007361)2.39683104
42Absent forearm bone (HP:0003953)2.37288078
43Aplasia involving forearm bones (HP:0009822)2.37288078
44Peritonitis (HP:0002586)2.32820938
45Aortic aneurysm (HP:0004942)2.30211907
46Aortic dissection (HP:0002647)2.29998591
47Abnormal number of erythroid precursors (HP:0012131)2.29948122
48Dilatation of the ascending aorta (HP:0005111)2.28810357
49Poikiloderma (HP:0001029)2.28749279
50Astrocytoma (HP:0009592)2.26350285
51Abnormality of the astrocytes (HP:0100707)2.26350285
52Shallow orbits (HP:0000586)2.26234587
53Abnormality of the duodenum (HP:0002246)2.25835727
54Proximal placement of thumb (HP:0009623)2.24599108
55Ectopic kidney (HP:0000086)2.24148981
56Nephroblastoma (Wilms tumor) (HP:0002667)2.23455094
57Oral leukoplakia (HP:0002745)2.23222474
58Slender long bone (HP:0003100)2.21058904
59Bifid tongue (HP:0010297)2.18641163
60Multiple enchondromatosis (HP:0005701)2.18297528
61Fair hair (HP:0002286)2.17921867
62Rough bone trabeculation (HP:0100670)2.17782665
63Abnormal lung lobation (HP:0002101)2.17520062
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.17114107
65Bilateral microphthalmos (HP:0007633)2.16966188
66Embryonal renal neoplasm (HP:0011794)2.16689303
67Short 4th metacarpal (HP:0010044)2.14312277
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14312277
69Chorioretinal atrophy (HP:0000533)2.13011603
70Entropion (HP:0000621)2.10758952
71Genu recurvatum (HP:0002816)2.09882971
72Glossoptosis (HP:0000162)2.09183458
73Mesomelia (HP:0003027)2.07714077
74Macrocytic anemia (HP:0001972)2.06317777
75Increased connective tissue (HP:0009025)2.05131072
76Abnormality of the carotid arteries (HP:0005344)2.04285631
77Neoplasm of the pancreas (HP:0002894)2.04258966
78Pallor (HP:0000980)2.02410361
79Breast hypoplasia (HP:0003187)2.02272434
80Microretrognathia (HP:0000308)1.99749510
81Abnormality of the acetabulum (HP:0003170)1.99648920
82Abnormality of midbrain morphology (HP:0002418)1.99113671
83Molar tooth sign on MRI (HP:0002419)1.99113671
84Atresia of the external auditory canal (HP:0000413)1.98354537
85Biliary tract neoplasm (HP:0100574)1.97983308
86Blue sclerae (HP:0000592)1.96617281
87Nephronophthisis (HP:0000090)1.95786282
8811 pairs of ribs (HP:0000878)1.93970991
89Rhabdomyosarcoma (HP:0002859)1.93169725
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.92906151
91Abnormality of the peritoneum (HP:0002585)1.92602097
92Abnormality of serum amino acid levels (HP:0003112)1.92083462
93Cerebellar dysplasia (HP:0007033)1.91711775
94Small hand (HP:0200055)1.91375862
95Clubbing of toes (HP:0100760)1.91094267
96Missing ribs (HP:0000921)1.91023589
97Cutaneous melanoma (HP:0012056)1.90926300
98Oligodactyly (hands) (HP:0001180)1.90490395
99* Soft skin (HP:0000977)1.90320981
100Genital tract atresia (HP:0001827)1.89236823
101Hypoplastic labia majora (HP:0000059)1.88883634
102Wormian bones (HP:0002645)1.87856129
103Triphalangeal thumb (HP:0001199)1.87310368
104Dandy-Walker malformation (HP:0001305)1.86468573
105Scrotal hypoplasia (HP:0000046)1.85027995
106Bowel diverticulosis (HP:0005222)1.84700205
107Neonatal short-limb short stature (HP:0008921)1.84289192
108Spinal rigidity (HP:0003306)1.84064335
109Wrist flexion contracture (HP:0001239)1.83917321
110Vaginal atresia (HP:0000148)1.83848004
111Abnormal auditory evoked potentials (HP:0006958)1.83797579
112Hyperventilation (HP:0002883)1.83444596
113Gaze-evoked nystagmus (HP:0000640)1.82079032
114Basal cell carcinoma (HP:0002671)1.81996450
115Increased mean platelet volume (HP:0011877)1.81737866
116Chronic hepatic failure (HP:0100626)1.81675231
117Osteolytic defects of the hand bones (HP:0009699)1.81616088
118Osteolytic defects of the phalanges of the hand (HP:0009771)1.81616088
119Cerebral aneurysm (HP:0004944)1.80872022
120Neoplasm of the adrenal cortex (HP:0100641)1.80698541
121Bile duct proliferation (HP:0001408)1.80286359
122Abnormal biliary tract physiology (HP:0012439)1.80286359
123Radial bowing (HP:0002986)1.79873194
124Progressive inability to walk (HP:0002505)1.79745955
125Abnormality of the renal medulla (HP:0100957)1.79325597
126Abnormal hemoglobin (HP:0011902)1.78873559
127Preaxial hand polydactyly (HP:0001177)1.78641149
128Medulloblastoma (HP:0002885)1.78259849
129Sparse lateral eyebrow (HP:0005338)1.78064283
130Genetic anticipation (HP:0003743)1.77743650
131Squamous cell carcinoma (HP:0002860)1.77366976
132Calcaneovalgus deformity (HP:0001848)1.76528530
133Breech presentation (HP:0001623)1.76105251
134Abnormality of the labia majora (HP:0012881)1.75960703
135Pelvic girdle muscle weakness (HP:0003749)1.75384945
136Esophageal atresia (HP:0002032)1.73906762
137Myelodysplasia (HP:0002863)1.73853746
138Ependymoma (HP:0002888)1.73851559
139High pitched voice (HP:0001620)1.72708023
140Preaxial foot polydactyly (HP:0001841)1.72679019
141Intestinal atresia (HP:0011100)1.72528489
142Sclerocornea (HP:0000647)1.72498376
143Central scotoma (HP:0000603)1.72410171
144Bladder diverticulum (HP:0000015)1.71844143
145Pendular nystagmus (HP:0012043)1.71547083
146Abnormality of chromosome stability (HP:0003220)1.71539914
147Increased nuchal translucency (HP:0010880)1.71517388
148Attenuation of retinal blood vessels (HP:0007843)1.70695099
149Gastrointestinal atresia (HP:0002589)1.70670513
150Atrophic scars (HP:0001075)1.70319697
151Supernumerary spleens (HP:0009799)1.68808982
152Patellar aplasia (HP:0006443)1.68467393
153Medial flaring of the eyebrow (HP:0010747)1.68390767
154Abnormality of the distal phalanges of the toes (HP:0010182)1.68088035
155Duplicated collecting system (HP:0000081)1.67983699
156Rectal prolapse (HP:0002035)1.67825515
157Delayed cranial suture closure (HP:0000270)1.67405126
158Anophthalmia (HP:0000528)1.66823455
159Abnormal platelet volume (HP:0011876)1.66671681
160Abnormality of the umbilical cord (HP:0010881)1.66216909
161Abnormality of dentin (HP:0010299)1.66091685
162Poor head control (HP:0002421)1.63730249
163Neoplasm of the colon (HP:0100273)1.63569935
164Horseshoe kidney (HP:0000085)1.62688838
165Clitoromegaly (HP:0000057)1.62604353
166Decreased skull ossification (HP:0004331)1.61656324
167Clumsiness (HP:0002312)1.60892117
168Astigmatism (HP:0000483)1.60055076
169Spastic diplegia (HP:0001264)1.59887287
170Absent thumb (HP:0009777)1.59782259
171Mitral valve prolapse (HP:0001634)1.59411483
172Congenital primary aphakia (HP:0007707)1.59010741
173Microvesicular hepatic steatosis (HP:0001414)1.58994265
174Abnormal cartilage morphology (HP:0002763)1.58679654
175Aplasia/Hypoplasia of the patella (HP:0006498)1.58474787
176Neoplasm of the small intestine (HP:0100833)1.58241265
177Abnormality of the 4th metacarpal (HP:0010012)1.57163891
178Angiofibromas (HP:0010615)1.57073663
179Adenoma sebaceum (HP:0009720)1.57073663
180Abnormality of DNA repair (HP:0003254)1.56975354
181Poor coordination (HP:0002370)1.56847227
182Chromsome breakage (HP:0040012)1.56298485
183Deformed tarsal bones (HP:0008119)1.55463911
184Limb-girdle muscle atrophy (HP:0003797)1.54876848
185Abnormal delivery (HP:0001787)1.53529409
186Meckel diverticulum (HP:0002245)1.52913896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.18819382
2CDC73.38844940
3BUB13.12601161
4WEE13.11593539
5EIF2AK13.05796790
6BMPR1B3.01058952
7NME22.95782516
8MST42.61709581
9RPS6KA42.30833411
10TESK22.30162670
11PKN22.03615145
12MST1R1.95921161
13SCYL21.95160769
14NEK21.93220377
15NEK11.86843006
16BRSK21.85525729
17TNIK1.85232308
18TGFBR11.82087505
19STK391.81876786
20MKNK11.81313827
21STK101.78648679
22RPS6KB21.72611450
23NUAK11.67052739
24PASK1.65336582
25EEF2K1.65011441
26ACVR1B1.64840578
27PAK41.64699437
28TRIB31.60550493
29LRRK21.59257016
30TTN1.58292248
31MAP3K81.54123017
32EIF2AK31.52971457
33FLT31.51924720
34TTK1.51706882
35WNK41.48183989
36TRIM281.47845401
37AURKB1.47832304
38TESK11.46995369
39MET1.46674374
40PIM21.46620551
41CDK71.46478730
42PLK11.45529053
43TSSK61.43240878
44TLK11.38496884
45NEK91.38282978
46CASK1.38128031
47TAF11.34976002
48BRD41.31701316
49PAK21.28459367
50SRPK11.27543618
51KDR1.27538195
52LATS21.21343131
53MAP3K101.19403573
54ATR1.18118019
55WNK31.17873803
56DDR21.15724143
57CDK121.14113577
58PLK31.13507493
59EPHA21.12750014
60LIMK11.11727904
61MAP2K31.11357041
62CDK41.07188658
63LATS11.06681709
64PNCK1.05666899
65OXSR11.05137747
66CDK61.05030839
67MAP3K111.03234691
68ADRBK20.97913084
69PLK40.97263888
70INSRR0.97006121
71VRK10.93759219
72CDK80.93272697
73AURKA0.91581959
74ERBB40.90841996
75BRSK10.90144136
76PDGFRA0.89340743
77STK30.89164887
78BCR0.88246725
79CHEK10.84296587
80ILK0.83246588
81STK160.81785600
82VRK20.79900748
83NME10.79338900
84CHEK20.77427922
85TRPM70.77383114
86GRK10.76388557
87MKNK20.76233631
88MAP3K30.75368904
89AKT30.74638225
90DYRK30.74462121
91FGFR10.71208202
92TAOK20.69932575
93ZAP700.69018526
94PAK10.68265663
95ERN10.64663545
96CSNK1A1L0.64616995
97MOS0.63728905
98ZAK0.62400412
99ATM0.61585941
100ALK0.60341818
101STK40.59824228
102CDK30.59580160
103PIM10.58251967
104MAP4K10.56888012
105CDK20.54921466
106PTK60.52573980
107JAK30.52341997
108MELK0.50684032
109MTOR0.50318751
110CSNK1G10.49856315
111CSNK2A20.49517457
112ERBB30.48815340
113ADRBK10.48192287
114CSNK2A10.47163998
115MAP3K40.47019611
116PTK20.46867818
117TGFBR20.46210630
118MAPKAPK50.45687277
119MAPKAPK30.45237626
120CAMK1G0.44996479
121NLK0.43100275
122TEC0.42883157
123CAMK1D0.42748981
124PBK0.42534664
125STK38L0.42389594
126BCKDK0.41748927
127PRKCE0.40599385
128BTK0.40174797
129BMX0.39753299
130EIF2AK20.39377073
131MAP4K20.36731124
132CDK10.34952648
133ABL20.34464487
134PRKG20.34379994
135PLK20.34224903
136KIT0.34179059
137CSNK1E0.32744770
138PRKDC0.27599406
139CSNK1D0.27453225
140WNK10.24514693
141STK240.23892930
142CSNK1G30.23099978
143CSNK1G20.22900988
144PRKAA20.20761850

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.39508125
2Ribosome_Homo sapiens_hsa030103.43263808
3Mismatch repair_Homo sapiens_hsa034303.41901320
4One carbon pool by folate_Homo sapiens_hsa006703.14541397
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12394275
6RNA transport_Homo sapiens_hsa030132.78678415
7Spliceosome_Homo sapiens_hsa030402.75514672
8Proteasome_Homo sapiens_hsa030502.68390233
9Cell cycle_Homo sapiens_hsa041102.54215254
10Nucleotide excision repair_Homo sapiens_hsa034202.52045303
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49667794
12Base excision repair_Homo sapiens_hsa034102.48674860
13Homologous recombination_Homo sapiens_hsa034402.35463780
14RNA polymerase_Homo sapiens_hsa030202.16463475
15Pyrimidine metabolism_Homo sapiens_hsa002402.01339263
16p53 signaling pathway_Homo sapiens_hsa041151.83343847
17Propanoate metabolism_Homo sapiens_hsa006401.79947120
18RNA degradation_Homo sapiens_hsa030181.61440409
19Non-homologous end-joining_Homo sapiens_hsa034501.55075801
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50704259
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44900610
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38079132
23Fanconi anemia pathway_Homo sapiens_hsa034601.35601194
24mRNA surveillance pathway_Homo sapiens_hsa030151.31224416
25Vitamin B6 metabolism_Homo sapiens_hsa007501.30888636
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20858591
27Butanoate metabolism_Homo sapiens_hsa006501.19649720
28Basal transcription factors_Homo sapiens_hsa030221.17401518
29Small cell lung cancer_Homo sapiens_hsa052221.16633092
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13859818
31Lysine degradation_Homo sapiens_hsa003101.12669071
32Viral carcinogenesis_Homo sapiens_hsa052031.12662862
33Phototransduction_Homo sapiens_hsa047441.10565163
34Selenocompound metabolism_Homo sapiens_hsa004501.09816516
35Epstein-Barr virus infection_Homo sapiens_hsa051691.09514750
36Antigen processing and presentation_Homo sapiens_hsa046121.07109263
37Thyroid cancer_Homo sapiens_hsa052161.06110597
38Biosynthesis of amino acids_Homo sapiens_hsa012301.05800482
39MicroRNAs in cancer_Homo sapiens_hsa052061.02124125
40Systemic lupus erythematosus_Homo sapiens_hsa053220.98902700
41HTLV-I infection_Homo sapiens_hsa051660.98081305
42Nitrogen metabolism_Homo sapiens_hsa009100.97346539
43Shigellosis_Homo sapiens_hsa051310.97249968
44Bladder cancer_Homo sapiens_hsa052190.97062665
45Pyruvate metabolism_Homo sapiens_hsa006200.97024325
46Tryptophan metabolism_Homo sapiens_hsa003800.94820904
47Herpes simplex infection_Homo sapiens_hsa051680.94756179
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94300098
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92729148
50Folate biosynthesis_Homo sapiens_hsa007900.92628197
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92512010
52Protein export_Homo sapiens_hsa030600.91918206
53Steroid biosynthesis_Homo sapiens_hsa001000.91372184
54Legionellosis_Homo sapiens_hsa051340.89695572
55Fatty acid biosynthesis_Homo sapiens_hsa000610.89030365
56Hedgehog signaling pathway_Homo sapiens_hsa043400.88251223
57Viral myocarditis_Homo sapiens_hsa054160.84152110
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83760053
59Sulfur relay system_Homo sapiens_hsa041220.83622469
60TGF-beta signaling pathway_Homo sapiens_hsa043500.83618522
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.83307002
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.80137867
63Adherens junction_Homo sapiens_hsa045200.79413666
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79212519
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79170833
66Purine metabolism_Homo sapiens_hsa002300.78964980
67Chronic myeloid leukemia_Homo sapiens_hsa052200.78613543
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78196010
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77907689
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77367430
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74334297
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.73956493
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72584653
74Carbon metabolism_Homo sapiens_hsa012000.72072428
75* Cysteine and methionine metabolism_Homo sapiens_hsa002700.71343222
76Proteoglycans in cancer_Homo sapiens_hsa052050.71243093
77ECM-receptor interaction_Homo sapiens_hsa045120.67856185
78Glutathione metabolism_Homo sapiens_hsa004800.67569678
79Apoptosis_Homo sapiens_hsa042100.66868287
80Pentose phosphate pathway_Homo sapiens_hsa000300.66542347
81Hippo signaling pathway_Homo sapiens_hsa043900.65060943
82beta-Alanine metabolism_Homo sapiens_hsa004100.65036589
83Retinol metabolism_Homo sapiens_hsa008300.65009020
84Ether lipid metabolism_Homo sapiens_hsa005650.63825012
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.63744956
86N-Glycan biosynthesis_Homo sapiens_hsa005100.63709889
87Focal adhesion_Homo sapiens_hsa045100.63052853
88Hepatitis B_Homo sapiens_hsa051610.62262225
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62232841
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62056135
91Linoleic acid metabolism_Homo sapiens_hsa005910.61996263
92Olfactory transduction_Homo sapiens_hsa047400.60711139
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60085789
94Taste transduction_Homo sapiens_hsa047420.59554982
95Caffeine metabolism_Homo sapiens_hsa002320.58971977
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.58412931
97Measles_Homo sapiens_hsa051620.54427139
98Colorectal cancer_Homo sapiens_hsa052100.53856536
99Wnt signaling pathway_Homo sapiens_hsa043100.53365211
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52733534
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51805158
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51106877
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50524320
104* Metabolic pathways_Homo sapiens_hsa011000.50379494
105Glycerolipid metabolism_Homo sapiens_hsa005610.49463310
106Fatty acid metabolism_Homo sapiens_hsa012120.49078771
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.47830354
108Oocyte meiosis_Homo sapiens_hsa041140.47722763
109Fatty acid degradation_Homo sapiens_hsa000710.47540629
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46352953
111ABC transporters_Homo sapiens_hsa020100.46264068
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45923257
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45809164
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44378116
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43942867
116Malaria_Homo sapiens_hsa051440.43729110
117Basal cell carcinoma_Homo sapiens_hsa052170.43656152
118Pancreatic cancer_Homo sapiens_hsa052120.42214311
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41980054
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.41864034
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41499030
122HIF-1 signaling pathway_Homo sapiens_hsa040660.40845327
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40827888
124Pathways in cancer_Homo sapiens_hsa052000.39188908
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38934872
126Peroxisome_Homo sapiens_hsa041460.38760937
127Chemical carcinogenesis_Homo sapiens_hsa052040.38394500
128Acute myeloid leukemia_Homo sapiens_hsa052210.37629642
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36816479
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36720603
131Melanoma_Homo sapiens_hsa052180.35560490
132Galactose metabolism_Homo sapiens_hsa000520.35423595
133Nicotine addiction_Homo sapiens_hsa050330.34607349
134Leishmaniasis_Homo sapiens_hsa051400.34389752
135Prostate cancer_Homo sapiens_hsa052150.34305007
136Arginine and proline metabolism_Homo sapiens_hsa003300.33260751
137Primary immunodeficiency_Homo sapiens_hsa053400.32412748
138Tight junction_Homo sapiens_hsa045300.30749657
139TNF signaling pathway_Homo sapiens_hsa046680.29004740
140Hematopoietic cell lineage_Homo sapiens_hsa046400.28669302
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27774997
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27554387
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27525895
144Circadian rhythm_Homo sapiens_hsa047100.25855238
145Toxoplasmosis_Homo sapiens_hsa051450.25791534
146Histidine metabolism_Homo sapiens_hsa003400.25450313
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.24240944
148Vitamin digestion and absorption_Homo sapiens_hsa049770.23641395
149Sulfur metabolism_Homo sapiens_hsa009200.23163831
150Huntingtons disease_Homo sapiens_hsa050160.21530858
151Platelet activation_Homo sapiens_hsa046110.21289067
152Influenza A_Homo sapiens_hsa051640.20955822

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