ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.78650969
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.83986924
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.80183738
4	ATP synthesis coupled proton transport (GO:0015986)	5.59028859
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.59028859
6	cytidine metabolic process (GO:0046087)	4.98521898
7	cytidine catabolic process (GO:0006216)	4.98521898
8	cytidine deamination (GO:0009972)	4.98521898
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.93294949
10	pseudouridine synthesis (GO:0001522)	4.38304645
11	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.35248383
12	electron transport chain (GO:0022900)	4.32334783
13	respiratory electron transport chain (GO:0022904)	4.32073896
14	behavioral response to nicotine (GO:0035095)	4.29764910
15	water-soluble vitamin biosynthetic process (GO:0042364)	4.28531814
16	protein complex biogenesis (GO:0070271)	3.91422948
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.80811902
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.80811902
19	NADH dehydrogenase complex assembly (GO:0010257)	3.80811902
20	protein neddylation (GO:0045116)	3.74295903
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61144727
22	respiratory chain complex IV assembly (GO:0008535)	3.54138368
23	hydrogen ion transmembrane transport (GO:1902600)	3.53317298
24	rRNA catabolic process (GO:0016075)	3.44878676
25	platelet dense granule organization (GO:0060155)	3.40845731
26	cytochrome complex assembly (GO:0017004)	3.35560815
27	ATP biosynthetic process (GO:0006754)	3.31370676
28	L-fucose catabolic process (GO:0042355)	3.30394850
29	fucose catabolic process (GO:0019317)	3.30394850
30	L-fucose metabolic process (GO:0042354)	3.30394850
31	proton transport (GO:0015992)	3.28371536
32	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.27694006
33	detection of light stimulus involved in sensory perception (GO:0050962)	3.26704345
34	detection of light stimulus involved in visual perception (GO:0050908)	3.26704345
35	hydrogen transport (GO:0006818)	3.22916114
36	positive regulation of prostaglandin secretion (GO:0032308)	3.22523485
37	rRNA modification (GO:0000154)	3.22374169
38	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.18565062
39	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.18565062
40	piRNA metabolic process (GO:0034587)	3.17551182
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.15306463
42	response to pheromone (GO:0019236)	3.15032542
43	sulfation (GO:0051923)	3.14573297
44	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.14116363
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.08858188
46	regulation of female receptivity (GO:0045924)	3.07707893
47	positive regulation of defense response to virus by host (GO:0002230)	3.07376879
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.03789758
49	preassembly of GPI anchor in ER membrane (GO:0016254)	3.03726075
50	indolalkylamine metabolic process (GO:0006586)	2.99008006
51	tryptophan catabolic process (GO:0006569)	2.97349601
52	indole-containing compound catabolic process (GO:0042436)	2.97349601
53	indolalkylamine catabolic process (GO:0046218)	2.97349601
54	protein polyglutamylation (GO:0018095)	2.90508313
55	kynurenine metabolic process (GO:0070189)	2.84931870
56	dopamine transport (GO:0015872)	2.81212628
57	maturation of 5.8S rRNA (GO:0000460)	2.80065655
58	regulation of regulatory T cell differentiation (GO:0045589)	2.79443598
59	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.75601965
60	positive regulation of fatty acid transport (GO:2000193)	2.75487176
61	regulation of memory T cell differentiation (GO:0043380)	2.73627597
62	sleep (GO:0030431)	2.72821897
63	tryptophan metabolic process (GO:0006568)	2.72766233
64	positive regulation of calcium-mediated signaling (GO:0050850)	2.72666898
65	negative regulation of telomere maintenance (GO:0032205)	2.71701871
66	termination of RNA polymerase III transcription (GO:0006386)	2.71629658
67	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.71629658
68	fat-soluble vitamin catabolic process (GO:0042363)	2.70830554
69	vitamin catabolic process (GO:0009111)	2.70830554
70	negative regulation by host of viral transcription (GO:0043922)	2.70085337
71	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.69894399
72	female mating behavior (GO:0060180)	2.67710105
73	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.65068919
74	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.58867240
75	chaperone-mediated protein transport (GO:0072321)	2.58742363
76	regulation of prostaglandin secretion (GO:0032306)	2.54906113
77	adenosine metabolic process (GO:0046085)	2.52528302
78	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.51672128
79	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.51298802
80	regulation of T cell mediated cytotoxicity (GO:0001914)	2.51004932
81	positive regulation of icosanoid secretion (GO:0032305)	2.49560171
82	cellular response to ATP (GO:0071318)	2.48540696
83	negative regulation of mast cell activation (GO:0033004)	2.47921619
84	DNA methylation involved in gamete generation (GO:0043046)	2.44912098
85	proteasome assembly (GO:0043248)	2.41728652
86	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.41231964
87	DNA demethylation (GO:0080111)	2.40742797
88	tRNA processing (GO:0008033)	2.40683551
89	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.40623977
90	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.40284978
91	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.39183800
92	regulation of mitotic spindle checkpoint (GO:1903504)	2.39183800
93	GTP biosynthetic process (GO:0006183)	2.37568643
94	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.36065544
95	neuronal action potential (GO:0019228)	2.35725096
96	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.34202290
97	response to interferon-beta (GO:0035456)	2.33979707
98	rhodopsin mediated signaling pathway (GO:0016056)	2.33412630
99	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.33065394
100	vitamin biosynthetic process (GO:0009110)	2.32837990

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.89963526
2	VDR_22108803_ChIP-Seq_LS180_Human	3.32235010
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.86263705
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.77595767
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.76216184
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40502283
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.38736063
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.36241930
9	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.33381018
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.28798526
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.20154738
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.16985527
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.09388450
14	EWS_26573619_Chip-Seq_HEK293_Human	2.00810255
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92348715
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.88161474
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.81784535
18	TP53_22573176_ChIP-Seq_HFKS_Human	1.78397728
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.78192246
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.76450504
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.75009326
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.74329748
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72493928
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.70354009
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.66675548
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66005858
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.65490511
28	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.64533753
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.63118126
30	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.60110610
31	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.55831515
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.53880848
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.53565431
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51512339
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51512339
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50470444
37	FUS_26573619_Chip-Seq_HEK293_Human	1.49144082
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47642717
39	P300_19829295_ChIP-Seq_ESCs_Human	1.47545869
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.47095907
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47030024
42	GATA3_26560356_Chip-Seq_TH2_Human	1.46824915
43	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.43803694
44	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43435503
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.42907498
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.42267902
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41706587
48	NCOR_22424771_ChIP-Seq_293T_Human	1.40134881
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39699074
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39267073
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39267073
52	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.37180360
53	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.34181329
54	AR_20517297_ChIP-Seq_VCAP_Human	1.34013327
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34002958
56	TAF15_26573619_Chip-Seq_HEK293_Human	1.32544954
57	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.32045056
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31911236
59	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.25592954
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25025894
61	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25018681
62	HOXB7_26014856_ChIP-Seq_BT474_Human	1.23351805
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21722241
64	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20729801
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20060883
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19725608
67	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.19623746
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.19121724
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19121724
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.18622130
71	MYC_19829295_ChIP-Seq_ESCs_Human	1.17235650
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16485495
73	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15170942
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14568109
75	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12879499
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12582048
77	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11661269
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11439543
79	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.09840063
80	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06930703
81	ERG_20517297_ChIP-Seq_VCAP_Human	1.06038447
82	ERA_21632823_ChIP-Seq_H3396_Human	1.04754450
83	P53_21459846_ChIP-Seq_SAOS-2_Human	1.03997920
84	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.03616068
85	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.02136094
86	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01693768
87	TCF4_22108803_ChIP-Seq_LS180_Human	1.00906584
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99904914
89	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.99248253
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98775272
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98755988
92	MYB_26560356_Chip-Seq_TH2_Human	0.96795914
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.96461764
94	RUNX_20019798_ChIP-Seq_JUKART_Human	0.96242899
95	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95882946
96	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95864882
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.95297137
98	AR_25329375_ChIP-Seq_VCAP_Human	0.95289740
99	TCF4_23295773_ChIP-Seq_U87_Human	0.94978642
100	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94221149

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	3.40089315
2	MP0005671_abnormal_response_to	3.13548609
3	MP0001968_abnormal_touch/_nociception	2.97146786
4	MP0005646_abnormal_pituitary_gland	2.81544690
5	MP0008877_abnormal_DNA_methylation	2.77588955
6	MP0006292_abnormal_olfactory_placode	2.45952114
7	MP0008872_abnormal_physiological_respon	2.41582777
8	MP0003195_calcinosis	2.17570219
9	MP0002277_abnormal_respiratory_mucosa	2.14846911
10	MP0006072_abnormal_retinal_apoptosis	2.02605400
11	MP0003806_abnormal_nucleotide_metabolis	1.94876722
12	MP0004885_abnormal_endolymph	1.94745478
13	MP0002653_abnormal_ependyma_morphology	1.93209572
14	MP0004147_increased_porphyrin_level	1.87511763
15	MP0005551_abnormal_eye_electrophysiolog	1.80029918
16	MP0002837_dystrophic_cardiac_calcinosis	1.79708908
17	MP0002138_abnormal_hepatobiliary_system	1.70311346
18	MP0002102_abnormal_ear_morphology	1.70118108
19	MP0003646_muscle_fatigue	1.68860687
20	MP0001835_abnormal_antigen_presentation	1.66250045
21	MP0008875_abnormal_xenobiotic_pharmacok	1.64071773
22	MP0000372_irregular_coat_pigmentation	1.63663311
23	MP0002876_abnormal_thyroid_physiology	1.60563069
24	MP0002148_abnormal_hypersensitivity_rea	1.56004788
25	MP0006276_abnormal_autonomic_nervous	1.53693449
26	MP0003283_abnormal_digestive_organ	1.51894093
27	MP0002163_abnormal_gland_morphology	1.51550423
28	MP0003011_delayed_dark_adaptation	1.48970310
29	MP0004043_abnormal_pH_regulation	1.47577260
30	MP0005389_reproductive_system_phenotype	1.44856370
31	MP0009785_altered_susceptibility_to	1.41880074
32	MP0001986_abnormal_taste_sensitivity	1.40833714
33	MP0005645_abnormal_hypothalamus_physiol	1.40571261
34	MP0005379_endocrine/exocrine_gland_phen	1.39655617
35	MP0001919_abnormal_reproductive_system	1.35582674
36	MP0009333_abnormal_splenocyte_physiolog	1.35070983
37	MP0001800_abnormal_humoral_immune	1.34563408
38	MP0003950_abnormal_plasma_membrane	1.34370696
39	MP0003718_maternal_effect	1.33739062
40	MP0002272_abnormal_nervous_system	1.33464472
41	MP0009745_abnormal_behavioral_response	1.33189886
42	MP0006036_abnormal_mitochondrial_physio	1.28767725
43	MP0005360_urolithiasis	1.28599143
44	MP0005075_abnormal_melanosome_morpholog	1.25766837
45	MP0005253_abnormal_eye_physiology	1.25506711
46	MP0001970_abnormal_pain_threshold	1.24625307
47	MP0005000_abnormal_immune_tolerance	1.24623200
48	MP0005084_abnormal_gallbladder_morpholo	1.24264568
49	MP0002733_abnormal_thermal_nociception	1.23794920
50	MP0002160_abnormal_reproductive_system	1.23498526
51	MP0005410_abnormal_fertilization	1.20675398
52	MP0003724_increased_susceptibility_to	1.20285201
53	MP0001790_abnormal_immune_system	1.18160024
54	MP0005387_immune_system_phenotype	1.18160024
55	MP0002693_abnormal_pancreas_physiology	1.17819245
56	MP0000230_abnormal_systemic_arterial	1.17257213
57	MP0001501_abnormal_sleep_pattern	1.16362245
58	MP0005636_abnormal_mineral_homeostasis	1.12519890
59	MP0002735_abnormal_chemical_nociception	1.12326092
60	MP0000685_abnormal_immune_system	1.12166703
61	MP0002723_abnormal_immune_serum	1.11432677
62	MP0004215_abnormal_myocardial_fiber	1.10877672
63	MP0000631_abnormal_neuroendocrine_gland	1.08513446
64	MP0001905_abnormal_dopamine_level	1.07989420
65	MP0004742_abnormal_vestibular_system	1.07048764
66	MP0009697_abnormal_copulation	1.07009511
67	MP0001485_abnormal_pinna_reflex	1.06335233
68	MP0004019_abnormal_vitamin_homeostasis	1.05966081
69	MP0009764_decreased_sensitivity_to	1.04125588
70	MP0001819_abnormal_immune_cell	1.03138380
71	MP0002420_abnormal_adaptive_immunity	1.02389321
72	MP0004145_abnormal_muscle_electrophysio	1.01398749
73	MP0009046_muscle_twitch	1.00657289
74	MP0001873_stomach_inflammation	0.99507039
75	MP0002909_abnormal_adrenal_gland	0.99490173
76	MP0001765_abnormal_ion_homeostasis	0.98495301
77	MP0005332_abnormal_amino_acid	0.96494671
78	MP0008775_abnormal_heart_ventricle	0.95162583
79	MP0002452_abnormal_antigen_presenting	0.93716948
80	MP0004142_abnormal_muscle_tone	0.91066477
81	MP0003638_abnormal_response/metabolism_	0.86670958
82	MP0001440_abnormal_grooming_behavior	0.86260507
83	MP0001486_abnormal_startle_reflex	0.86155716
84	MP0003878_abnormal_ear_physiology	0.84170854
85	MP0005377_hearing/vestibular/ear_phenot	0.84170854
86	MP0003252_abnormal_bile_duct	0.83589358
87	MP0001764_abnormal_homeostasis	0.83497818
88	MP0003866_abnormal_defecation	0.83475394
89	MP0002572_abnormal_emotion/affect_behav	0.82142187
90	MP0002928_abnormal_bile_duct	0.78118562
91	MP0002734_abnormal_mechanical_nocicepti	0.77711923
92	MP0005025_abnormal_response_to	0.76285556
93	MP0003693_abnormal_embryo_hatching	0.75654930
94	MP0003787_abnormal_imprinting	0.74789604
95	MP0010329_abnormal_lipoprotein_level	0.73620341
96	MP0001188_hyperpigmentation	0.71592162
97	MP0002132_abnormal_respiratory_system	0.70948639
98	MP0010386_abnormal_urinary_bladder	0.70708494
99	MP0000689_abnormal_spleen_morphology	0.70593475
100	MP0001845_abnormal_inflammatory_respons	0.70521334

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	3.77108709
2	IgG deficiency (HP:0004315)	3.69969758
3	Acute necrotizing encephalopathy (HP:0006965)	3.69940944
4	Mitochondrial inheritance (HP:0001427)	3.62222782
5	Increased CSF lactate (HP:0002490)	3.45691055
6	Decreased central vision (HP:0007663)	3.23939211
7	Abolished electroretinogram (ERG) (HP:0000550)	3.19230137
8	Progressive macrocephaly (HP:0004481)	3.16111453
9	Pancreatic cysts (HP:0001737)	3.14684247
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.11486462
11	Hepatocellular necrosis (HP:0001404)	3.03033396
12	Congenital, generalized hypertrichosis (HP:0004540)	3.00720334
13	Acute encephalopathy (HP:0006846)	2.93929189
14	Stomatitis (HP:0010280)	2.92784894
15	Increased hepatocellular lipid droplets (HP:0006565)	2.88823561
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.82568484
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.80282249
18	Absent/shortened dynein arms (HP:0200106)	2.80282249
19	Lipid accumulation in hepatocytes (HP:0006561)	2.79056705
20	Hepatic necrosis (HP:0002605)	2.78636777
21	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.78118965
22	Abnormality of midbrain morphology (HP:0002418)	2.76369527
23	Molar tooth sign on MRI (HP:0002419)	2.76369527
24	Attenuation of retinal blood vessels (HP:0007843)	2.76138671
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.75553123
26	Methylmalonic acidemia (HP:0002912)	2.71769107
27	Pancreatic fibrosis (HP:0100732)	2.70409393
28	Abnormality of the renal cortex (HP:0011035)	2.64473746
29	Aplastic anemia (HP:0001915)	2.61740815
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.52296123
31	Renal Fanconi syndrome (HP:0001994)	2.51768842
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.49330086
33	Polydipsia (HP:0001959)	2.43360115
34	Abnormal drinking behavior (HP:0030082)	2.43360115
35	Abnormality of B cell number (HP:0010975)	2.42918473
36	Constricted visual fields (HP:0001133)	2.36970369
37	Cerebral edema (HP:0002181)	2.35204190
38	Renal cortical cysts (HP:0000803)	2.34838947
39	Methylmalonic aciduria (HP:0012120)	2.32260771
40	True hermaphroditism (HP:0010459)	2.31525531
41	Increased serum lactate (HP:0002151)	2.29732918
42	Keratoconus (HP:0000563)	2.29583949
43	Increased corneal curvature (HP:0100692)	2.29583949
44	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.29478888
45	Abnormality of alanine metabolism (HP:0010916)	2.28336951
46	Hyperalaninemia (HP:0003348)	2.28336951
47	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.28336951
48	Pendular nystagmus (HP:0012043)	2.26978314
49	Aplasia/hypoplasia of the uterus (HP:0008684)	2.26621402
50	3-Methylglutaconic aciduria (HP:0003535)	2.26257411
51	Severe combined immunodeficiency (HP:0004430)	2.26218572
52	Nephronophthisis (HP:0000090)	2.24855451
53	B lymphocytopenia (HP:0010976)	2.24252336
54	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.23422289
55	Optic disc pallor (HP:0000543)	2.17536139
56	Large for gestational age (HP:0001520)	2.15357556
57	Hypothermia (HP:0002045)	2.09821651
58	Abnormality of the pons (HP:0007361)	2.09572286
59	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.07139646
60	Thyroiditis (HP:0100646)	2.03743340
61	Hypoplasia of the uterus (HP:0000013)	2.02374709
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.01938609
63	Abnormality of T cells (HP:0002843)	2.00202223
64	T lymphocytopenia (HP:0005403)	1.97590003
65	Hypomagnesemia (HP:0002917)	1.96184740
66	Polyuria (HP:0000103)	1.95585310
67	Hypoplasia of the fovea (HP:0007750)	1.94308725
68	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.94308725
69	Exertional dyspnea (HP:0002875)	1.94205238
70	Abnormality of the renal medulla (HP:0100957)	1.93150671
71	Abnormal number of erythroid precursors (HP:0012131)	1.92749551
72	Bony spicule pigmentary retinopathy (HP:0007737)	1.91502920
73	Hypoproteinemia (HP:0003075)	1.90780969
74	Abnormality of T cell number (HP:0011839)	1.88945111
75	Congenital sensorineural hearing impairment (HP:0008527)	1.88850914
76	Abnormal respiratory motile cilium morphology (HP:0005938)	1.86917307
77	Abnormal respiratory epithelium morphology (HP:0012253)	1.86917307
78	Lactic acidosis (HP:0003128)	1.86849608
79	Tetany (HP:0001281)	1.85827459
80	Decreased circulating renin level (HP:0003351)	1.84023447
81	Abnormality of T cell physiology (HP:0011840)	1.83539546
82	Abnormal ciliary motility (HP:0012262)	1.83331268
83	Hypoplasia of the pons (HP:0012110)	1.83113672
84	Increased intramyocellular lipid droplets (HP:0012240)	1.82975806
85	Type II lissencephaly (HP:0007260)	1.82377033
86	Generalized aminoaciduria (HP:0002909)	1.82080543
87	Abnormal albumin level (HP:0012116)	1.80565390
88	Hypoalbuminemia (HP:0003073)	1.80565390
89	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.80373655
90	Glycosuria (HP:0003076)	1.79896989
91	Abnormality of urine glucose concentration (HP:0011016)	1.79896989
92	Lethargy (HP:0001254)	1.78806831
93	Azoospermia (HP:0000027)	1.77425825
94	Severe visual impairment (HP:0001141)	1.76403170
95	Abnormality of renal resorption (HP:0011038)	1.76303980
96	Respiratory failure (HP:0002878)	1.75090966
97	Keratoconjunctivitis (HP:0001096)	1.74958819
98	Abnormality of the renal collecting system (HP:0004742)	1.74680285
99	Increased IgM level (HP:0003496)	1.74428493
100	Abnormality of homocysteine metabolism (HP:0010919)	1.74125117

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.70730115
2	TLK1	3.79730641
3	TXK	3.53505332
4	ZAK	3.50424503
5	ADRBK2	3.06574085
6	GRK1	2.96215312
7	FRK	2.89193203
8	NUAK1	2.44241996
9	MST4	2.25716078
10	KDR	2.25045136
11	WNK4	2.15507420
12	MAP4K2	2.15329831
13	VRK2	2.14758226
14	PINK1	2.08201381
15	TESK2	1.75619945
16	TEC	1.69826935
17	VRK1	1.66988915
18	BMPR1B	1.65520343
19	MAP4K1	1.52058337
20	TIE1	1.48347288
21	ITK	1.41863240
22	IKBKB	1.34860460
23	WNK3	1.29854476
24	OXSR1	1.20935075
25	CAMKK2	1.18791863
26	ACVR1B	1.17707090
27	MAP2K2	1.17558761
28	BCKDK	1.16651773
29	SYK	1.11634069
30	TNIK	1.09139588
31	STK39	1.05552919
32	DAPK2	1.02647495
33	MAPKAPK3	1.02580372
34	BUB1	1.00748265
35	KIT	0.95432096
36	MAPK13	0.95349761
37	DYRK2	0.94116756
38	MAP3K12	0.92378623
39	TNK2	0.92292029
40	STK16	0.90342871
41	PHKG2	0.89308551
42	PHKG1	0.89308551
43	PRKCQ	0.85867998
44	PIK3CA	0.85150640
45	INSRR	0.83376443
46	GRK6	0.81967232
47	TAF1	0.81698446
48	NME1	0.81672900
49	MAP2K6	0.81350996
50	MYLK	0.80675273
51	ADRBK1	0.80160431
52	EIF2AK3	0.80000605
53	RPS6KA5	0.73579854
54	CSNK1G1	0.73169613
55	LYN	0.70467729
56	MUSK	0.69377729
57	EIF2AK2	0.68640666
58	DAPK1	0.68513299
59	IKBKE	0.68239345
60	GRK7	0.67847706
61	PTK2B	0.64881993
62	BRSK2	0.63354180
63	CSNK1G3	0.61819945
64	PLK3	0.61707259
65	PASK	0.60841267
66	OBSCN	0.60409997
67	PRKCG	0.58451534
68	CSNK1G2	0.58427608
69	BTK	0.58215219
70	PRKCE	0.58181791
71	MAP3K14	0.57985006
72	LCK	0.57886817
73	GRK5	0.57306876
74	PLK2	0.57205226
75	FES	0.56575379
76	PIK3CG	0.56147902
77	TRPM7	0.52869607
78	NLK	0.48802521
79	CSNK1A1	0.44703537
80	CAMK2A	0.44634169
81	PRKCA	0.43801587
82	MKNK2	0.43775331
83	PRKACA	0.43404187
84	PRKCI	0.41138686
85	PLK4	0.41117407
86	MAPKAPK5	0.40579789
87	CHEK2	0.40252720
88	CHUK	0.39852850
89	PRKG1	0.37752758
90	IGF1R	0.36783191
91	SRPK1	0.34843857
92	MAPK15	0.33877516
93	BLK	0.33815970
94	CAMK1	0.32948263
95	TBK1	0.32089715
96	CDC7	0.32017538
97	PAK3	0.31673984
98	CSNK1A1L	0.31212074
99	ALK	0.31125755
100	PLK1	0.30951157

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.58458575
2	Parkinsons disease_Homo sapiens_hsa05012	2.94307611
3	Primary immunodeficiency_Homo sapiens_hsa05340	2.79951453
4	Proteasome_Homo sapiens_hsa03050	2.66843776
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.35898133
6	RNA polymerase_Homo sapiens_hsa03020	2.29057711
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23685051
8	Phototransduction_Homo sapiens_hsa04744	2.20255551
9	Protein export_Homo sapiens_hsa03060	2.19671035
10	Asthma_Homo sapiens_hsa05310	2.19388384
11	Alzheimers disease_Homo sapiens_hsa05010	1.99241118
12	Allograft rejection_Homo sapiens_hsa05330	1.94291338
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.93033708
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.88222398
15	Ribosome_Homo sapiens_hsa03010	1.87526488
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.87035245
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78757308
18	Huntingtons disease_Homo sapiens_hsa05016	1.78197367
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.77928938
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.77810972
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.76016500
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.75458197
23	Graft-versus-host disease_Homo sapiens_hsa05332	1.75010216
24	One carbon pool by folate_Homo sapiens_hsa00670	1.71578121
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71465413
26	Type I diabetes mellitus_Homo sapiens_hsa04940	1.66599729
27	Homologous recombination_Homo sapiens_hsa03440	1.64152227
28	Sulfur metabolism_Homo sapiens_hsa00920	1.51630349
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43569537
30	RNA degradation_Homo sapiens_hsa03018	1.42569659
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.40122337
32	Antigen processing and presentation_Homo sapiens_hsa04612	1.35834585
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.33142989
34	Olfactory transduction_Homo sapiens_hsa04740	1.29945549
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.23444035
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.23137238
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22627588
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.22086078
39	Basal transcription factors_Homo sapiens_hsa03022	1.20374940
40	Caffeine metabolism_Homo sapiens_hsa00232	1.17943175
41	Retinol metabolism_Homo sapiens_hsa00830	1.17820894
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.16725221
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.07326139
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.06495771
45	Sulfur relay system_Homo sapiens_hsa04122	1.05054123
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05003380
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02738477
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.02548174
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02518802
50	Rheumatoid arthritis_Homo sapiens_hsa05323	1.01607382
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.00640649
52	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.97256383
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.95333026
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94778898
55	Butanoate metabolism_Homo sapiens_hsa00650	0.91657349
56	Taste transduction_Homo sapiens_hsa04742	0.91530007
57	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91290028
58	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.91005820
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.88821263
60	Purine metabolism_Homo sapiens_hsa00230	0.86161393
61	Peroxisome_Homo sapiens_hsa04146	0.81109449
62	Nicotine addiction_Homo sapiens_hsa05033	0.78550784
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.72213742
64	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.68340558
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.68011825
66	Morphine addiction_Homo sapiens_hsa05032	0.66668352
67	Serotonergic synapse_Homo sapiens_hsa04726	0.66541721
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66269860
69	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.65091757
70	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61630430
71	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60209120
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57458120
73	Metabolic pathways_Homo sapiens_hsa01100	0.55715227
74	Spliceosome_Homo sapiens_hsa03040	0.52364635
75	Propanoate metabolism_Homo sapiens_hsa00640	0.52319416
76	Folate biosynthesis_Homo sapiens_hsa00790	0.51293691
77	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.51012107
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.50958489
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.46979663
80	Insulin secretion_Homo sapiens_hsa04911	0.45993824
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45140602
82	Regulation of autophagy_Homo sapiens_hsa04140	0.43444833
83	RNA transport_Homo sapiens_hsa03013	0.43333986
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42746859
85	Mineral absorption_Homo sapiens_hsa04978	0.41337429
86	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41335181
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40824066
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40457582
89	Mismatch repair_Homo sapiens_hsa03430	0.39665238
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38897105
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34711786
92	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.34454918
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.34048852
94	Glutathione metabolism_Homo sapiens_hsa00480	0.33441923
95	Circadian entrainment_Homo sapiens_hsa04713	0.33424840
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.30954871
97	Histidine metabolism_Homo sapiens_hsa00340	0.30283079
98	GABAergic synapse_Homo sapiens_hsa04727	0.29148367
99	Nucleotide excision repair_Homo sapiens_hsa03420	0.26995826
100	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.26663309

MTATP6P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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