MTCH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.41818368
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.09517211
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78338527
4locomotory exploration behavior (GO:0035641)4.76312445
5protein localization to endosome (GO:0036010)4.54492325
6protein retention in ER lumen (GO:0006621)4.37488652
7layer formation in cerebral cortex (GO:0021819)4.33252894
8synaptic vesicle exocytosis (GO:0016079)4.24278100
9glutamate secretion (GO:0014047)4.23800202
10COPI coating of Golgi vesicle (GO:0048205)4.11961700
11Golgi transport vesicle coating (GO:0048200)4.11961700
12regulation of synaptic vesicle exocytosis (GO:2000300)4.11512702
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.08874300
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.07610160
15vocalization behavior (GO:0071625)3.92978444
16dendritic spine morphogenesis (GO:0060997)3.85980864
17regulation of synapse structural plasticity (GO:0051823)3.85597265
18activation of protein kinase A activity (GO:0034199)3.83505838
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.74560853
20protein maturation by protein folding (GO:0022417)3.73244241
21exploration behavior (GO:0035640)3.67874133
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.67125471
23regulation of synaptic vesicle transport (GO:1902803)3.61362782
24neurotransmitter secretion (GO:0007269)3.59052745
25regulation of glutamate receptor signaling pathway (GO:1900449)3.56673172
26cerebellar Purkinje cell layer development (GO:0021680)3.56593756
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.55756378
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.53067099
29regulation of neuronal synaptic plasticity (GO:0048168)3.49840748
30barbed-end actin filament capping (GO:0051016)3.40857067
31sodium ion export (GO:0071436)3.37460146
32cerebellar granule cell differentiation (GO:0021707)3.34872209
33negative regulation of catenin import into nucleus (GO:0035414)3.32195621
34cell communication by electrical coupling (GO:0010644)3.30129274
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30112357
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29076406
37protein localization to synapse (GO:0035418)3.28480074
38mating behavior (GO:0007617)3.25655627
39proline transport (GO:0015824)3.21765330
40regulation of early endosome to late endosome transport (GO:2000641)3.21523734
41positive regulation of synaptic transmission, GABAergic (GO:0032230)3.20884029
42neuronal action potential propagation (GO:0019227)3.20355646
43neuron recognition (GO:0008038)3.19485026
44cytoskeletal anchoring at plasma membrane (GO:0007016)3.17385101
45amino acid import (GO:0043090)3.12768658
46dendrite morphogenesis (GO:0048813)3.10580159
47positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.08134258
48neuromuscular process controlling balance (GO:0050885)3.07423359
49negative regulation of microtubule polymerization (GO:0031115)3.04965192
50skin morphogenesis (GO:0043589)3.03389329
51cellular potassium ion homeostasis (GO:0030007)3.01496584
52neuron cell-cell adhesion (GO:0007158)2.99650417
53axonal fasciculation (GO:0007413)2.94740166
54G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.93928041
55adherens junction assembly (GO:0034333)2.93261379
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92209655
57cell-cell junction maintenance (GO:0045217)2.91064682
58regulation of dendritic spine morphogenesis (GO:0061001)2.90704069
59cell migration in hindbrain (GO:0021535)2.89249113
60ionotropic glutamate receptor signaling pathway (GO:0035235)2.88923801
61negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.88010660
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87728439
63stress fiber assembly (GO:0043149)2.87658938
64protein targeting to plasma membrane (GO:0072661)2.86781147
65regulation of mammary gland epithelial cell proliferation (GO:0033599)2.85214923
66long-term memory (GO:0007616)2.84592033
67suckling behavior (GO:0001967)2.81705755
68neurotransmitter transport (GO:0006836)2.80133721
69planar cell polarity pathway involved in neural tube closure (GO:0090179)2.79705184
70anatomical structure maturation (GO:0071695)2.79266302
71gamma-aminobutyric acid transport (GO:0015812)2.79098716
72cortical actin cytoskeleton organization (GO:0030866)2.78060599
73regulation of vesicle fusion (GO:0031338)2.75310362
74prepulse inhibition (GO:0060134)2.73817894
75positive regulation of synapse maturation (GO:0090129)2.71994426
76glycine transport (GO:0015816)2.70172198
77actin filament depolymerization (GO:0030042)2.69940150
78neuromuscular process controlling posture (GO:0050884)2.68947456
79cell-substrate adherens junction assembly (GO:0007045)2.68299312
80focal adhesion assembly (GO:0048041)2.68299312
81synaptic transmission, glutamatergic (GO:0035249)2.67196346
82dendritic spine organization (GO:0097061)2.67036499
83semaphorin-plexin signaling pathway (GO:0071526)2.66010582
84negative regulation of organelle assembly (GO:1902116)2.65228847
85regulation of neurotransmitter levels (GO:0001505)2.64660292
86positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.64391912
87regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.64391912
88synaptic vesicle endocytosis (GO:0048488)2.60587446
89regulation of synaptic plasticity (GO:0048167)2.60461452
90axon cargo transport (GO:0008088)2.59835767
91establishment of nucleus localization (GO:0040023)2.58865307
92vesicle transport along microtubule (GO:0047496)2.58762541
93dopamine receptor signaling pathway (GO:0007212)2.58150732
94plasma membrane repair (GO:0001778)2.57858243
95activation of Rac GTPase activity (GO:0032863)2.56638314
96type B pancreatic cell proliferation (GO:0044342)2.56394961
97auditory behavior (GO:0031223)2.55880299
98organelle transport along microtubule (GO:0072384)2.54341344
99membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.53745988
100cellular copper ion homeostasis (GO:0006878)2.53513617
101regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.53460977
102innervation (GO:0060384)2.53169538
103membrane repolarization (GO:0086009)2.52304643
104regulation of excitatory postsynaptic membrane potential (GO:0060079)2.52161629
105positive regulation of membrane potential (GO:0045838)2.51718502
106regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50972289
107neuron-neuron synaptic transmission (GO:0007270)2.50600574
108cell communication involved in cardiac conduction (GO:0086065)2.49342948
109regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.47946994
110synapse organization (GO:0050808)2.47647529
111regulation of clathrin-mediated endocytosis (GO:2000369)2.47209149
112positive regulation of dendritic spine development (GO:0060999)2.46732254
113cortical cytoskeleton organization (GO:0030865)2.46216741
114epithelial cell-cell adhesion (GO:0090136)2.45731358
115potassium ion homeostasis (GO:0055075)2.45720402
116axon extension (GO:0048675)2.44551196
117response to auditory stimulus (GO:0010996)2.43300419
118clathrin coat assembly (GO:0048268)2.43055224
119establishment of mitochondrion localization (GO:0051654)2.42677944
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.42232355
121cellular response to monoamine stimulus (GO:0071868)2.42104941
122cellular response to catecholamine stimulus (GO:0071870)2.42104941
123positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.41665767
124regulation of postsynaptic membrane potential (GO:0060078)2.41498561
125regulation of neurotransmitter secretion (GO:0046928)2.40394225
126positive regulation of protein dephosphorylation (GO:0035307)2.39910056
127regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39283544
128positive regulation of dendritic spine morphogenesis (GO:0061003)2.39045641
129basement membrane organization (GO:0071711)2.38437572
130regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.38396462
131neuromuscular process (GO:0050905)2.37830425
132regulation of ARF protein signal transduction (GO:0032012)2.37475622
133cellular sodium ion homeostasis (GO:0006883)2.37346263
134positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.36876740
135L-amino acid import (GO:0043092)2.36489576
136neuron projection extension (GO:1990138)2.36372027
137synapse assembly (GO:0007416)2.35967836
138positive regulation of potassium ion transmembrane transport (GO:1901381)2.35944935
139regulation of extracellular matrix disassembly (GO:0010715)2.35570142
140glutamate receptor signaling pathway (GO:0007215)2.35549894
141regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.35506053
142activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35171246
143positive regulation of fibroblast migration (GO:0010763)2.35092121
144postsynaptic membrane organization (GO:0001941)2.34911344
145regulation of glucose import in response to insulin stimulus (GO:2001273)2.34758200
146calcium-mediated signaling using intracellular calcium source (GO:0035584)2.33888964
147neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.33486250
148receptor recycling (GO:0001881)2.31780193
149maternal placenta development (GO:0001893)2.31222404
150endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.30734382
151negative regulation of cell size (GO:0045792)2.30534112
152cell-substrate junction assembly (GO:0007044)2.30483784
153peptidyl-proline hydroxylation (GO:0019511)2.29786603
154mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.29506462
155vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.29413939
156regulation of synapse maturation (GO:0090128)2.29358193
157positive regulation of axon extension (GO:0045773)2.28091122
158response to gravity (GO:0009629)2.25746752
159activation of MAPKKK activity (GO:0000185)2.24965877
160vesicle coating (GO:0006901)2.24898904
161mitochondrion transport along microtubule (GO:0047497)2.24660655
162establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.24660655
163* neuronal ion channel clustering (GO:0045161)2.21759353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.57255520
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.34164536
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96716495
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88421234
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85003706
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85003706
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81550644
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77856627
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55061924
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54047694
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.53158561
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51516005
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.51038719
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.45850579
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43697176
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.37449602
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36629490
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36101565
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.34421247
20DROSHA_22980978_ChIP-Seq_HELA_Human2.32794747
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30249616
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.27176373
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.23679917
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.17976980
25* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.17813470
26REST_21632747_ChIP-Seq_MESCs_Mouse2.08269841
27ERG_21242973_ChIP-ChIP_JURKAT_Human2.08117620
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06760728
29* IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04908013
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99404136
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.97093032
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93483090
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93468442
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.90714687
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89168437
36KDM2B_26808549_Chip-Seq_K562_Human1.87750095
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.80432537
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78488149
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77210215
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.76018859
41* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.71352478
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69659468
43VDR_21846776_ChIP-Seq_THP-1_Human1.68941778
44LXR_22292898_ChIP-Seq_THP-1_Human1.68365467
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66827611
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.66208078
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.61921026
48* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59596959
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.58336655
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54502135
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53030644
52TCF7_22412390_ChIP-Seq_EML_Mouse1.49833544
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49235674
54* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48958342
55GBX2_23144817_ChIP-Seq_PC3_Human1.45039426
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44421949
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44292205
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42273223
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40905813
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39746563
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.37432011
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37423552
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37338605
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36552097
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36027955
66MYC_22102868_ChIP-Seq_BL_Human1.35206755
67CTCF_27219007_Chip-Seq_Bcells_Human1.34928467
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.33519315
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33317471
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33161103
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32627724
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32381431
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31784105
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.30167513
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29894918
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29634451
77* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29586033
78KDM2B_26808549_Chip-Seq_DND41_Human1.29284553
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26593010
80TP53_22127205_ChIP-Seq_IMR90_Human1.26482765
81* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24099914
82ZNF274_21170338_ChIP-Seq_K562_Hela1.23023028
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22987844
84AR_21572438_ChIP-Seq_LNCaP_Human1.20554489
85* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19718739
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.19322775
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18178399
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17538191
89SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17206901
90ZNF263_19887448_ChIP-Seq_K562_Human1.15782822
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14373753
92ATF3_27146783_Chip-Seq_COLON_Human1.13611297
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13247368
94* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13228959
95CREB1_26743006_Chip-Seq_LNCaP_Human1.12578847
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11695311
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11048543
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10046935
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09282154
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.08024519
101* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07272099
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07229467
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06861558
104* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06530588
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06421847
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04318247
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.04211157
108AR_19668381_ChIP-Seq_PC3_Human1.03989961
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03603204
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03365239
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03233001
112SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02717088
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02588233
114SMC4_20622854_ChIP-Seq_HELA_Human1.01731541
115HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99855908
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99599035
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98995335
118RACK7_27058665_Chip-Seq_MCF-7_Human0.98928177
119UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95869808
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.95702009
121TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95345411
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.95262780
123KLF4_19829295_ChIP-Seq_ESCs_Human0.94221085
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93432283
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92315986
126JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92120105
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.92101486
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91688425
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91566840
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84261113
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83706374
132CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83683173
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83397846
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.83002611
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82713569
136CLOCK_20551151_ChIP-Seq_293T_Human0.82076216
137CBX2_27304074_Chip-Seq_ESCs_Mouse0.81806068
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.81755065
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78154832
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.78038692
141AHR_22903824_ChIP-Seq_MCF-7_Human0.77528797
142TP53_23651856_ChIP-Seq_MEFs_Mouse0.77412977
143P68_20966046_ChIP-Seq_HELA_Human0.76050464
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.75231360
145ISL1_27105846_Chip-Seq_CPCs_Mouse0.74246133
146* TP63_22573176_ChIP-Seq_HFKS_Human0.73409679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.40174380
2MP0000013_abnormal_adipose_tissue3.63995599
3MP0003880_abnormal_central_pattern3.63902920
4MP0003635_abnormal_synaptic_transmissio3.32833388
5MP0004270_analgesia2.88188708
6MP0002063_abnormal_learning/memory/cond2.68100449
7MP0005257_abnormal_intraocular_pressure2.57852613
8MP0003566_abnormal_cell_adhesion2.43344513
9MP0009745_abnormal_behavioral_response2.37808676
10MP0004858_abnormal_nervous_system2.37740151
11MP0005058_abnormal_lysosome_morphology2.36327069
12MP0001968_abnormal_touch/_nociception2.33645627
13MP0002909_abnormal_adrenal_gland2.33414331
14MP0003283_abnormal_digestive_organ2.33110681
15MP0002064_seizures2.29716108
16MP0004510_myositis2.29567308
17MP0003122_maternal_imprinting2.26547478
18MP0009780_abnormal_chondrocyte_physiolo2.25875234
19MP0002822_catalepsy2.22782892
20MP0002877_abnormal_melanocyte_morpholog2.15399220
21MP0002572_abnormal_emotion/affect_behav2.14987608
22MP0009840_abnormal_foam_cell2.08932828
23MP0002734_abnormal_mechanical_nocicepti1.98943561
24MP0002733_abnormal_thermal_nociception1.95366580
25MP0000751_myopathy1.93126584
26MP0008260_abnormal_autophagy1.92534744
27MP0005423_abnormal_somatic_nervous1.90607862
28MP0003329_amyloid_beta_deposits1.89808452
29MP0001849_ear_inflammation1.82385903
30MP0002272_abnormal_nervous_system1.79287967
31MP0005623_abnormal_meninges_morphology1.77907349
32MP0000003_abnormal_adipose_tissue1.77591519
33MP0009046_muscle_twitch1.71748334
34MP0001486_abnormal_startle_reflex1.68990005
35MP0002736_abnormal_nociception_after1.68408518
36MP0001970_abnormal_pain_threshold1.66857414
37MP0006276_abnormal_autonomic_nervous1.62212149
38MP0003191_abnormal_cellular_cholesterol1.62171793
39MP0001440_abnormal_grooming_behavior1.61738679
40MP0004811_abnormal_neuron_physiology1.57678864
41MP0003279_aneurysm1.55097131
42MP0003091_abnormal_cell_migration1.53687574
43MP0000955_abnormal_spinal_cord1.51116505
44MP0003705_abnormal_hypodermis_morpholog1.50922569
45MP0000778_abnormal_nervous_system1.47715493
46MP0008961_abnormal_basal_metabolism1.47612650
47MP0003879_abnormal_hair_cell1.47531019
48MP0002184_abnormal_innervation1.45231222
49MP0002735_abnormal_chemical_nociception1.41948337
50MP0000920_abnormal_myelination1.39477877
51MP0002067_abnormal_sensory_capabilities1.38609564
52MP0004185_abnormal_adipocyte_glucose1.37835821
53MP0003690_abnormal_glial_cell1.34329105
54MP0001501_abnormal_sleep_pattern1.33474421
55MP0003453_abnormal_keratinocyte_physiol1.31867717
56MP0005409_darkened_coat_color1.31139702
57MP0002557_abnormal_social/conspecific_i1.31065881
58MP0002837_dystrophic_cardiac_calcinosis1.28430466
59MP0008438_abnormal_cutaneous_collagen1.28423334
60MP0008569_lethality_at_weaning1.27832964
61MP0004885_abnormal_endolymph1.27274208
62MP0004924_abnormal_behavior1.23232984
63MP0005386_behavior/neurological_phenoty1.23232984
64MP0002882_abnormal_neuron_morphology1.22920271
65MP0000681_abnormal_thyroid_gland1.22510136
66MP0005451_abnormal_body_composition1.22477446
67MP0010368_abnormal_lymphatic_system1.21174749
68MP0002234_abnormal_pharynx_morphology1.18931088
69MP0002066_abnormal_motor_capabilities/c1.18756203
70MP0010234_abnormal_vibrissa_follicle1.18368861
71MP0000537_abnormal_urethra_morphology1.13276133
72MP0000534_abnormal_ureter_morphology1.12705966
73MP0003172_abnormal_lysosome_physiology1.09731286
74MP0001299_abnormal_eye_distance/1.07621881
75MP0003633_abnormal_nervous_system1.07334781
76MP0008874_decreased_physiological_sensi1.06533020
77MP0005165_increased_susceptibility_to1.02300247
78MP0005076_abnormal_cell_differentiation1.02085744
79MP0000747_muscle_weakness1.00323379
80MP0005645_abnormal_hypothalamus_physiol1.00314784
81MP0004145_abnormal_muscle_electrophysio0.99154798
82MP0002152_abnormal_brain_morphology0.98661664
83MP0005167_abnormal_blood-brain_barrier0.96806932
84MP0002796_impaired_skin_barrier0.95932607
85MP0004272_abnormal_basement_membrane0.95241014
86MP0009672_abnormal_birth_weight0.95216398
87MP0000750_abnormal_muscle_regeneration0.94222251
88MP0003634_abnormal_glial_cell0.92034910
89MP0003123_paternal_imprinting0.91337304
90MP0005023_abnormal_wound_healing0.89495149
91MP0005508_abnormal_skeleton_morphology0.88932184
92MP0005501_abnormal_skin_physiology0.86433404
93MP0001348_abnormal_lacrimal_gland0.85991243
94MP0001958_emphysema0.85743804
95MP0005503_abnormal_tendon_morphology0.84782006
96MP0010386_abnormal_urinary_bladder0.84145047
97MP0000733_abnormal_muscle_development0.84113690
98MP0000462_abnormal_digestive_system0.83733142
99MP0005275_abnormal_skin_tensile0.83019314
100MP0000759_abnormal_skeletal_muscle0.82603372
101MP0003878_abnormal_ear_physiology0.82477052
102MP0005377_hearing/vestibular/ear_phenot0.82477052
103MP0004085_abnormal_heartbeat0.82391501
104MP0003300_gastrointestinal_ulcer0.81923808
105MP0005666_abnormal_adipose_tissue0.81904007
106MP0001177_atelectasis0.80896835
107MP0002069_abnormal_eating/drinking_beha0.80627738
108MP0000678_abnormal_parathyroid_gland0.80539364
109MP0003631_nervous_system_phenotype0.80251094
110MP0003075_altered_response_to0.79884882
111MP0010352_gastrointestinal_tract_polyps0.79155978
112MP0002249_abnormal_larynx_morphology0.79035119
113MP0002060_abnormal_skin_morphology0.79011375
114MP0004233_abnormal_muscle_weight0.78466288
115MP0001529_abnormal_vocalization0.78021205
116MP0005375_adipose_tissue_phenotype0.77650356
117MP0003385_abnormal_body_wall0.77635988
118MP0001502_abnormal_circadian_rhythm0.77525171
119MP0000767_abnormal_smooth_muscle0.77367387
120MP0005646_abnormal_pituitary_gland0.76956613
121MP0003942_abnormal_urinary_system0.76832171
122MP0000343_altered_response_to0.76316533
123MP0002089_abnormal_postnatal_growth/wei0.76256716
124MP0009278_abnormal_bone_marrow0.75507077
125MP0001905_abnormal_dopamine_level0.74657679
126MP0005621_abnormal_cell_physiology0.74284953
127MP0010030_abnormal_orbit_morphology0.73844353
128MP0004087_abnormal_muscle_fiber0.73564257
129MP0005187_abnormal_penis_morphology0.73425407
130MP0004742_abnormal_vestibular_system0.73108748
131MP0001943_abnormal_respiration0.72926221
132MP0001542_abnormal_bone_strength0.72198425
133MP0000858_altered_metastatic_potential0.71606572
134MP0009053_abnormal_anal_canal0.71549950
135MP0003787_abnormal_imprinting0.71088055
136MP0009379_abnormal_foot_pigmentation0.71071958
137MP0003119_abnormal_digestive_system0.70715186
138MP0000604_amyloidosis0.69577638
139MP0002896_abnormal_bone_mineralization0.69049402
140MP0000631_abnormal_neuroendocrine_gland0.67853383
141MP0002998_abnormal_bone_remodeling0.67458467
142MP0001485_abnormal_pinna_reflex0.66581627
143MP0003137_abnormal_impulse_conducting0.66572173
144MP0002229_neurodegeneration0.66264167
145MP0001664_abnormal_digestion0.66143607
146MP0000749_muscle_degeneration0.64359258
147MP0005535_abnormal_body_temperature0.64026331
148MP0004043_abnormal_pH_regulation0.62207122

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.11074860
2Visual hallucinations (HP:0002367)3.65558519
3Supranuclear gaze palsy (HP:0000605)3.57419925
4Focal motor seizures (HP:0011153)3.40334146
5Focal seizures (HP:0007359)3.30468991
6Megalencephaly (HP:0001355)3.15936827
7Vertebral compression fractures (HP:0002953)3.03227147
8Obstructive sleep apnea (HP:0002870)2.96755626
9Insomnia (HP:0100785)2.91014041
10Ankle clonus (HP:0011448)2.84634704
11Cerebral inclusion bodies (HP:0100314)2.84027423
12Action tremor (HP:0002345)2.83526016
13Failure to thrive in infancy (HP:0001531)2.78821129
14Depression (HP:0000716)2.73229163
15Distal lower limb amyotrophy (HP:0008944)2.71385551
16Hand muscle atrophy (HP:0009130)2.71061233
17Papilledema (HP:0001085)2.69300295
18Hypercortisolism (HP:0001578)2.65789651
19Hypoventilation (HP:0002791)2.64093325
20Poor eye contact (HP:0000817)2.64063967
21Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.54541295
22Torticollis (HP:0000473)2.52981101
23Hyperparathyroidism (HP:0000843)2.52153110
24Neuronal loss in central nervous system (HP:0002529)2.52094359
25Neurofibrillary tangles (HP:0002185)2.51636700
26Hyperacusis (HP:0010780)2.50508637
27Termporal pattern (HP:0011008)2.49627010
28Insidious onset (HP:0003587)2.49627010
29Cerebral aneurysm (HP:0004944)2.49149460
30Mitral regurgitation (HP:0001653)2.48116670
31Limb dystonia (HP:0002451)2.47943862
32Anxiety (HP:0000739)2.44328987
33Abnormal social behavior (HP:0012433)2.42659216
34Impaired social interactions (HP:0000735)2.42659216
35Ventricular fibrillation (HP:0001663)2.40920812
36Pheochromocytoma (HP:0002666)2.40663338
37Protrusio acetabuli (HP:0003179)2.33015906
38Difficulty climbing stairs (HP:0003551)2.30852252
39Ulnar bowing (HP:0003031)2.30059766
40Axonal loss (HP:0003447)2.28116762
41Arterial tortuosity (HP:0005116)2.25176890
42Rapidly progressive (HP:0003678)2.24330330
43Atonic seizures (HP:0010819)2.23184689
44Overgrowth (HP:0001548)2.22748956
45Focal dystonia (HP:0004373)2.22654075
46Fragile nails (HP:0001808)2.22119997
47Vascular tortuosity (HP:0004948)2.20942491
48Buphthalmos (HP:0000557)2.20650983
49Abnormality of the lower motor neuron (HP:0002366)2.19260774
50Long palpebral fissure (HP:0000637)2.19025276
51Bladder diverticulum (HP:0000015)2.18682451
52Abnormal eating behavior (HP:0100738)2.18320751
53Distal lower limb muscle weakness (HP:0009053)2.16637086
54Turricephaly (HP:0000262)2.16000737
55Amblyopia (HP:0000646)2.15612452
56Pointed chin (HP:0000307)2.14877024
57Craniofacial dystonia (HP:0012179)2.14750994
58Agitation (HP:0000713)2.14590553
59Spinal rigidity (HP:0003306)2.14289956
60Absence seizures (HP:0002121)2.14138028
61Short nail (HP:0001799)2.13429877
62Ankyloglossia (HP:0010296)2.12595856
63Hamartoma of the eye (HP:0010568)2.10282993
64Bronchomalacia (HP:0002780)2.09053887
65Achilles tendon contracture (HP:0001771)2.08954056
66Elfin facies (HP:0004428)2.08248516
67Renal duplication (HP:0000075)2.08189018
68Shallow orbits (HP:0000586)2.07169589
69Generalized tonic-clonic seizures (HP:0002069)2.05013041
70Upper limb amyotrophy (HP:0009129)2.04213212
71Distal upper limb amyotrophy (HP:0007149)2.04213212
72Increased variability in muscle fiber diameter (HP:0003557)2.03531822
73Disproportionate tall stature (HP:0001519)2.02879967
74Broad face (HP:0000283)2.01038716
75Nuclear cataract (HP:0100018)2.00118789
76Urinary urgency (HP:0000012)2.00090352
77Progressive cerebellar ataxia (HP:0002073)1.99235681
78Bowel diverticulosis (HP:0005222)1.99025591
79Overriding aorta (HP:0002623)1.97918347
80Epileptic encephalopathy (HP:0200134)1.95329499
81Distal sensory impairment (HP:0002936)1.95059378
82Resting tremor (HP:0002322)1.94749098
83Neoplasm of the heart (HP:0100544)1.94740548
84Increased connective tissue (HP:0009025)1.94719136
85Lower limb asymmetry (HP:0100559)1.94355227
86Congenital glaucoma (HP:0001087)1.94157918
87Peripheral hypomyelination (HP:0007182)1.94062037
88Neoplasm of the peripheral nervous system (HP:0100007)1.93790323
89Atrophic scars (HP:0001075)1.93758215
90Wormian bones (HP:0002645)1.93192950
91Ankle contracture (HP:0006466)1.92886861
92Deep palmar crease (HP:0006191)1.91769691
93Mutism (HP:0002300)1.91624223
94Neuroendocrine neoplasm (HP:0100634)1.91520962
95Impaired vibration sensation in the lower limbs (HP:0002166)1.90848041
96Conjunctival hamartoma (HP:0100780)1.90572529
97Broad metatarsal (HP:0001783)1.88283736
98Fragile skin (HP:0001030)1.87808533
99Enlarged penis (HP:0000040)1.87633782
100Cervical subluxation (HP:0003308)1.87562755
101Centrally nucleated skeletal muscle fibers (HP:0003687)1.87097789
102Postural instability (HP:0002172)1.84987285
103Abnormality of the Achilles tendon (HP:0005109)1.84509246
104Hammertoe (HP:0001765)1.82978996
105Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81675617
106Bundle branch block (HP:0011710)1.80666433
107Spastic gait (HP:0002064)1.80546864
108Postural tremor (HP:0002174)1.80363268
109Growth hormone excess (HP:0000845)1.79880753
110Hyperthyroidism (HP:0000836)1.78956016
111Stereotypic behavior (HP:0000733)1.78779390
112Dialeptic seizures (HP:0011146)1.77452198
113Hemiplegia (HP:0002301)1.77305788
114Interstitial pulmonary disease (HP:0006530)1.77186954
115Truncal ataxia (HP:0002078)1.77026974
116Apathy (HP:0000741)1.77015306
117Scanning speech (HP:0002168)1.76645913
118Foot dorsiflexor weakness (HP:0009027)1.76194393
119Blue sclerae (HP:0000592)1.75697934
120Diplopia (HP:0000651)1.75423840
121Abnormality of binocular vision (HP:0011514)1.75423840
122Hypsarrhythmia (HP:0002521)1.75144336
123Annular pancreas (HP:0001734)1.74866807
124Cholecystitis (HP:0001082)1.74031149
125Abnormal gallbladder physiology (HP:0012438)1.74031149
126Premature rupture of membranes (HP:0001788)1.73946105
127Lower limb amyotrophy (HP:0007210)1.73596120
128Arnold-Chiari malformation (HP:0002308)1.73591612
129Genu recurvatum (HP:0002816)1.72509029
130EEG with generalized epileptiform discharges (HP:0011198)1.72444338
131Hypercalcemia (HP:0003072)1.72005312
132Diminished motivation (HP:0000745)1.71182632
133Subacute progressive viral hepatitis (HP:0006572)1.69992111
134Macroorchidism (HP:0000053)1.69880997
135Spinal cord compression (HP:0002176)1.68986098
136Renovascular hypertension (HP:0100817)1.67787419
137Dysmetria (HP:0001310)1.67382938
138Epileptiform EEG discharges (HP:0011182)1.67096105
139Hyperextensible skin (HP:0000974)1.66475944
140Mildly elevated creatine phosphokinase (HP:0008180)1.66117889
141Aplasia involving bones of the upper limbs (HP:0009823)1.66053211
142Aplasia of the phalanges of the hand (HP:0009802)1.66053211
143Aplasia involving bones of the extremities (HP:0009825)1.66053211
144Thin bony cortex (HP:0002753)1.65995266
145Precocious puberty (HP:0000826)1.65555550
146Osteolytic defects of the phalanges of the hand (HP:0009771)1.62050034
147Osteolytic defects of the hand bones (HP:0009699)1.62050034
148Aneurysm (HP:0002617)1.61886677
149Long toe (HP:0010511)1.61476960
150Dilatation of the ascending aorta (HP:0005111)1.61415804
151Patellar dislocation (HP:0002999)1.61406674
152Dysostosis multiplex (HP:0000943)1.60953697
153Abnormality of skeletal muscle fiber size (HP:0012084)1.60032651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.52619629
2MAP3K93.39554389
3TRIB33.10821094
4PRPF4B2.92582313
5TESK12.79267858
6EPHA42.69369625
7KSR22.61394719
8PRKD32.61225994
9MARK12.56805793
10IRAK32.55017623
11NTRK12.38452503
12MINK12.27744994
13PAK62.22874120
14PKN22.10086143
15CAMKK11.86183169
16EPHA21.85013603
17SMG11.84842998
18SIK11.84733037
19TAOK11.80627495
20MAP3K41.79965035
21DAPK21.79167793
22MAP3K21.76716819
23UHMK11.71984597
24ERN11.67416974
25NTRK21.62086545
26TYRO31.60116690
27NME21.59386394
28TESK21.57354748
29PDGFRA1.56982706
30LATS21.54346670
31KSR11.53400779
32MAP3K111.49730394
33DDR21.45889552
34CDK51.42747331
35LMTK21.42496609
36ARAF1.39886476
37RET1.39082909
38RIPK11.32994198
39TAOK21.29983728
40SCYL21.28893204
41MOS1.23360105
42MAP2K41.21915371
43PHKG21.19477649
44PHKG11.19477649
45PINK11.18216684
46PAK31.17998087
47PAK41.17569971
48CDK141.08191980
49PRKCH1.06433968
50DMPK1.03479957
51ALK1.02354207
52LIMK11.00845868
53MAP3K60.99978601
54EPHB20.99973143
55CDK150.99610865
56GRK50.98536384
57FER0.96895467
58CDK180.96394481
59MAP3K10.95306447
60ILK0.92856729
61WNK40.91714993
62SIK20.91462316
63CDK190.90990967
64MAP3K120.90700840
65ICK0.90661355
66EPHB10.90651922
67STK380.90025093
68IRAK20.89771276
69CDK11A0.86385653
70PIM20.84361077
71BMX0.82866430
72PTK20.82794538
73EEF2K0.81156473
74STK110.80881908
75FGFR40.77078816
76DAPK10.76585434
77PTK2B0.76301534
78ABL20.76234370
79FES0.75976909
80MARK20.75053212
81PTK60.74012758
82PRKCG0.73799224
83MAP3K130.73614630
84CDC42BPA0.72529911
85MAP2K70.72191831
86MAP2K10.71662470
87PDPK10.71659163
88PRKG20.69291355
89MAPK130.68763768
90DAPK30.68454724
91ROCK20.66246861
92FGFR20.65370358
93BRAF0.65309106
94MTOR0.64979302
95CAMK2A0.63658177
96RPS6KA20.63636220
97CAMK2G0.63081507
98MAP2K30.63078039
99CSNK1G20.62474529
100NEK10.61758039
101TTN0.61461472
102CAMKK20.61347111
103MAP2K20.61242123
104MAP3K100.59684018
105CAMK2B0.59116225
106CAMK1G0.57755927
107ROCK10.55807972
108RIPK40.55137154
109PAK20.55047321
110RAF10.54048361
111PDK10.53941533
112PLK20.53928884
113MAPK120.53472650
114PRKD20.51644630
115PRKD10.50639833
116WNK10.50420707
117PRKCZ0.49488224
118OXSR10.48711754
119HIPK20.47602275
120CAMK10.47571895
121BRSK10.47380656
122LRRK20.47309971
123PAK10.46800955
124SGK30.45781558
125FYN0.45251103
126MAP3K30.43955047
127CAMK2D0.43036155
128MAP3K80.43011836
129TNK20.42435637
130DYRK1B0.41201334
131PKN10.39576622
132MET0.38633265
133MAPK100.36495145
134TGFBR20.36089469
135AURKA0.35182766

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.73387115
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.41723336
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.20495618
4GABAergic synapse_Homo sapiens_hsa047272.06619349
5Long-term potentiation_Homo sapiens_hsa047202.06546490
6Olfactory transduction_Homo sapiens_hsa047402.05932003
7Nicotine addiction_Homo sapiens_hsa050332.01413289
8Circadian entrainment_Homo sapiens_hsa047131.99542712
9Amphetamine addiction_Homo sapiens_hsa050311.94132668
10Dopaminergic synapse_Homo sapiens_hsa047281.91948797
11Insulin secretion_Homo sapiens_hsa049111.88452064
12Cocaine addiction_Homo sapiens_hsa050301.86566633
13Cholinergic synapse_Homo sapiens_hsa047251.78427107
14Glutamatergic synapse_Homo sapiens_hsa047241.75761060
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74425934
16Morphine addiction_Homo sapiens_hsa050321.73038784
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72464613
18Gastric acid secretion_Homo sapiens_hsa049711.71626390
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62642812
20Salivary secretion_Homo sapiens_hsa049701.61619495
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59077663
22Gap junction_Homo sapiens_hsa045401.58191479
23Glioma_Homo sapiens_hsa052141.54880477
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50626766
25GnRH signaling pathway_Homo sapiens_hsa049121.46144958
26Estrogen signaling pathway_Homo sapiens_hsa049151.43444436
27Oxytocin signaling pathway_Homo sapiens_hsa049211.43179123
28Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.40953959
29Renin secretion_Homo sapiens_hsa049241.37899269
30Axon guidance_Homo sapiens_hsa043601.32991013
31Long-term depression_Homo sapiens_hsa047301.32007192
32Type II diabetes mellitus_Homo sapiens_hsa049301.29206877
33Melanogenesis_Homo sapiens_hsa049161.24275990
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23186410
35Other glycan degradation_Homo sapiens_hsa005111.22634683
36Vitamin B6 metabolism_Homo sapiens_hsa007501.19778464
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19493332
38Nitrogen metabolism_Homo sapiens_hsa009101.19242716
39Serotonergic synapse_Homo sapiens_hsa047261.15296964
40Taste transduction_Homo sapiens_hsa047421.13984332
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12789159
42VEGF signaling pathway_Homo sapiens_hsa043701.12127776
43Vibrio cholerae infection_Homo sapiens_hsa051101.12029514
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08858832
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06605542
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.04748923
47cAMP signaling pathway_Homo sapiens_hsa040241.04343603
48Dilated cardiomyopathy_Homo sapiens_hsa054141.03993508
49ErbB signaling pathway_Homo sapiens_hsa040121.03315092
50Biosynthesis of amino acids_Homo sapiens_hsa012301.02484862
51Notch signaling pathway_Homo sapiens_hsa043301.01939093
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01087160
53Cardiac muscle contraction_Homo sapiens_hsa042601.00969489
54Pancreatic cancer_Homo sapiens_hsa052120.99607321
55Collecting duct acid secretion_Homo sapiens_hsa049660.99504858
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.99145573
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.98618493
58Salmonella infection_Homo sapiens_hsa051320.98396741
59Calcium signaling pathway_Homo sapiens_hsa040200.98284186
60Renal cell carcinoma_Homo sapiens_hsa052110.97701103
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97105390
62Pentose phosphate pathway_Homo sapiens_hsa000300.96782506
63Endometrial cancer_Homo sapiens_hsa052130.95492299
64Dorso-ventral axis formation_Homo sapiens_hsa043200.95266843
65Sulfur relay system_Homo sapiens_hsa041220.94378076
66Galactose metabolism_Homo sapiens_hsa000520.90852823
67Non-small cell lung cancer_Homo sapiens_hsa052230.89403853
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87398791
69Shigellosis_Homo sapiens_hsa051310.86757623
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.86699114
71Thyroid hormone synthesis_Homo sapiens_hsa049180.86657996
72mTOR signaling pathway_Homo sapiens_hsa041500.86057587
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85900548
74Prion diseases_Homo sapiens_hsa050200.84917575
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82569505
76Bladder cancer_Homo sapiens_hsa052190.81958197
77Fructose and mannose metabolism_Homo sapiens_hsa000510.79637741
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78762885
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.77754879
80Adherens junction_Homo sapiens_hsa045200.77078306
81AMPK signaling pathway_Homo sapiens_hsa041520.76540903
82Acute myeloid leukemia_Homo sapiens_hsa052210.76391229
83Insulin signaling pathway_Homo sapiens_hsa049100.76287386
84Pancreatic secretion_Homo sapiens_hsa049720.76243721
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74974248
86Rap1 signaling pathway_Homo sapiens_hsa040150.73626068
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72873740
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71219663
89Lysosome_Homo sapiens_hsa041420.71199983
90Choline metabolism in cancer_Homo sapiens_hsa052310.70586242
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70522966
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69304023
93Focal adhesion_Homo sapiens_hsa045100.68194755
94Glucagon signaling pathway_Homo sapiens_hsa049220.68047088
95ECM-receptor interaction_Homo sapiens_hsa045120.67106934
96Endocytosis_Homo sapiens_hsa041440.66984675
97Inositol phosphate metabolism_Homo sapiens_hsa005620.66509730
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65981760
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64990154
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.64887549
101Hedgehog signaling pathway_Homo sapiens_hsa043400.64856877
102Oocyte meiosis_Homo sapiens_hsa041140.64598497
103Proteoglycans in cancer_Homo sapiens_hsa052050.63674680
104HIF-1 signaling pathway_Homo sapiens_hsa040660.63494102
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.62988222
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62886852
107Chronic myeloid leukemia_Homo sapiens_hsa052200.61911915
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60334717
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59393510
110Amoebiasis_Homo sapiens_hsa051460.58664856
111Tight junction_Homo sapiens_hsa045300.57799826
112Ras signaling pathway_Homo sapiens_hsa040140.57745637
113Alcoholism_Homo sapiens_hsa050340.57743239
114MAPK signaling pathway_Homo sapiens_hsa040100.56420634
115Bile secretion_Homo sapiens_hsa049760.56410395
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56185844
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55413181
118Colorectal cancer_Homo sapiens_hsa052100.50311753
119Hippo signaling pathway_Homo sapiens_hsa043900.50062799
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49329145
121Thyroid cancer_Homo sapiens_hsa052160.49040538
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48107593
123Wnt signaling pathway_Homo sapiens_hsa043100.47774350
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47348217
125Prolactin signaling pathway_Homo sapiens_hsa049170.47039664
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46585147
127Melanoma_Homo sapiens_hsa052180.46510516
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43888831

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