MTCO1P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.44245632
2antigen processing and presentation of endogenous antigen (GO:0019883)5.40580480
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.29110910
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.79456380
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.58665450
6Peyers patch development (GO:0048541)4.34644075
7mucosal-associated lymphoid tissue development (GO:0048537)4.34644075
8detection of bacterium (GO:0016045)4.30673346
9negative T cell selection (GO:0043383)4.26105025
10CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.21488061
11negative thymic T cell selection (GO:0045060)4.13806360
12regulation of B cell receptor signaling pathway (GO:0050855)4.06001984
13cytidine metabolic process (GO:0046087)4.03785313
14cytidine catabolic process (GO:0006216)4.03785313
15cytidine deamination (GO:0009972)4.03785313
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00076662
17negative regulation of cell killing (GO:0031342)4.00076662
18positive regulation of gamma-delta T cell activation (GO:0046645)3.93253588
19detection of other organism (GO:0098543)3.88211649
20regulation of alpha-beta T cell proliferation (GO:0046640)3.75982685
21positive regulation of granulocyte differentiation (GO:0030854)3.73709165
22response to type I interferon (GO:0034340)3.71807312
23immunoglobulin mediated immune response (GO:0016064)3.68280252
24NIK/NF-kappaB signaling (GO:0038061)3.67606030
25type I interferon signaling pathway (GO:0060337)3.62803946
26cellular response to type I interferon (GO:0071357)3.62803946
27regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.48089776
28interferon-gamma-mediated signaling pathway (GO:0060333)3.45428558
29regulation of gamma-delta T cell activation (GO:0046643)3.41785993
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39548098
31epoxygenase P450 pathway (GO:0019373)3.39108884
32thymic T cell selection (GO:0045061)3.38414130
33T cell costimulation (GO:0031295)3.36024724
34response to muramyl dipeptide (GO:0032495)3.35812324
35T cell lineage commitment (GO:0002360)3.34705080
36T-helper 1 type immune response (GO:0042088)3.33669483
37lymphocyte costimulation (GO:0031294)3.31884956
38T cell selection (GO:0045058)3.30546989
39positive thymic T cell selection (GO:0045059)3.28334627
40pyrimidine ribonucleoside catabolic process (GO:0046133)3.21279519
41negative regulation of myotube differentiation (GO:0010832)3.20011951
42positive T cell selection (GO:0043368)3.17994347
43angiotensin maturation (GO:0002003)3.15531082
44regulation of gamma-delta T cell differentiation (GO:0045586)3.13939536
45positive regulation of alpha-beta T cell proliferation (GO:0046641)3.13793723
46regulation of interleukin-2 biosynthetic process (GO:0045076)3.11645781
47mature B cell differentiation involved in immune response (GO:0002313)3.06288475
48B cell receptor signaling pathway (GO:0050853)3.03280514
49T cell migration (GO:0072678)3.02951435
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.01614925
51positive regulation by symbiont of host defense response (GO:0052509)2.94638345
52modulation by symbiont of host defense response (GO:0052031)2.94638345
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94638345
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94638345
55positive regulation by organism of defense response of other organism involved in symbiotic interact2.94638345
56modulation by symbiont of host immune response (GO:0052553)2.94638345
57negative regulation of leukocyte mediated immunity (GO:0002704)2.94515072
58regulation of interleukin-4 production (GO:0032673)2.93750570
59negative regulation of erythrocyte differentiation (GO:0045647)2.92017840
60negative regulation of thymocyte apoptotic process (GO:0070244)2.91413325
61regulation of hypersensitivity (GO:0002883)2.88771821
62atrioventricular valve morphogenesis (GO:0003181)2.87163027
63B cell proliferation (GO:0042100)2.86768063
64regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85568049
65detection of external biotic stimulus (GO:0098581)2.85115789
66negative regulation of T cell mediated immunity (GO:0002710)2.82486240
67regulation of granulocyte differentiation (GO:0030852)2.81047894
68regulation of interferon-beta biosynthetic process (GO:0045357)2.79360142
69B cell mediated immunity (GO:0019724)2.78192196
70urea metabolic process (GO:0019627)2.77126529
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76982847
72NADH metabolic process (GO:0006734)2.74267466
73coronary vasculature morphogenesis (GO:0060977)2.72065496
74cellular response to interferon-gamma (GO:0071346)2.71903627
75mature B cell differentiation (GO:0002335)2.70177844
76nitrogen cycle metabolic process (GO:0071941)2.67420873
77negative regulation of viral genome replication (GO:0045071)2.64156902
78regulation of alpha-beta T cell activation (GO:0046634)2.64070514
79urea cycle (GO:0000050)2.63357213
80cellular response to reactive nitrogen species (GO:1902170)2.63081434
81cGMP-mediated signaling (GO:0019934)2.62956202
82response to interferon-beta (GO:0035456)2.62039734
83positive regulation of interleukin-4 production (GO:0032753)2.59391317
84regulation of antigen processing and presentation (GO:0002577)2.56573537
85antigen processing and presentation via MHC class Ib (GO:0002475)2.55506818
86myeloid dendritic cell differentiation (GO:0043011)2.54193550
87regulation of cellular extravasation (GO:0002691)2.51712406
88myeloid dendritic cell activation (GO:0001773)2.51364879
89response to interferon-gamma (GO:0034341)2.50183011
90V(D)J recombination (GO:0033151)2.48198661
91regulation of T cell tolerance induction (GO:0002664)2.47653394
92alkaloid metabolic process (GO:0009820)2.47504916
93regulation of germinal center formation (GO:0002634)2.46402649
94B cell homeostasis (GO:0001782)2.46173463
95positive regulation of antigen processing and presentation (GO:0002579)2.45615340
96response to protozoan (GO:0001562)2.45162171
97peripheral nervous system neuron development (GO:0048935)2.42427877
98T-helper cell differentiation (GO:0042093)2.41584270
99CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.41584270
100positive regulation of interferon-alpha production (GO:0032727)2.40771370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.68872852
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.99680301
3MYC_22102868_ChIP-Seq_BL_Human3.73780748
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.12918070
5VDR_21846776_ChIP-Seq_THP-1_Human3.10023130
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58251600
7RUNX_20019798_ChIP-Seq_JUKART_Human2.56911669
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.55783611
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.45509773
10ZNF263_19887448_ChIP-Seq_K562_Human2.44483903
11MAF_26560356_Chip-Seq_TH1_Human2.34790498
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34229653
13UTX_26944678_Chip-Seq_JUKART_Human2.32014003
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.31476512
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.29760035
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.28341703
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20069417
18MYB_26560356_Chip-Seq_TH2_Human2.18169497
19VDR_24763502_ChIP-Seq_THP-1_Human2.16449690
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14109425
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12854675
22TCF7_22412390_ChIP-Seq_EML_Mouse2.09718453
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07147495
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06375333
25LXR_22292898_ChIP-Seq_THP-1_Human2.05946277
26MYB_26560356_Chip-Seq_TH1_Human2.03022626
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96186563
28MAF_26560356_Chip-Seq_TH2_Human1.94021777
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.91630651
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.91316248
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90736936
32E2F7_22180533_ChIP-Seq_HELA_Human1.85687856
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84563203
34KDM2B_26808549_Chip-Seq_DND41_Human1.83318676
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82436309
36SCL_19346495_ChIP-Seq_HPC-7_Human1.82303806
37SPI1_23127762_ChIP-Seq_K562_Human1.81157299
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80024327
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78540241
40GATA1_22025678_ChIP-Seq_K562_Human1.72933609
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71756888
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71189546
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70836651
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69832729
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65941477
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.58358505
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53216872
48CIITA_25753668_ChIP-Seq_RAJI_Human1.52140955
49SPI1_23547873_ChIP-Seq_NB4_Human1.51731472
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.51213157
51SMC4_20622854_ChIP-Seq_HELA_Human1.48704839
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.45306699
53BCOR_27268052_Chip-Seq_Bcells_Human1.44676671
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44393400
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.42533063
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40957541
57GATA1_19941826_ChIP-Seq_K562_Human1.38670126
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38180382
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.37930091
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36180571
61GATA3_27048872_Chip-Seq_THYMUS_Human1.35923531
62BCL6_27268052_Chip-Seq_Bcells_Human1.34133640
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34105365
64P68_20966046_ChIP-Seq_HELA_Human1.33834414
65SA1_27219007_Chip-Seq_Bcells_Human1.28618761
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.26998453
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26336756
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24534806
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22006713
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21366413
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20511875
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14696384
73RXR_22158963_ChIP-Seq_LIVER_Mouse1.13637486
74RACK7_27058665_Chip-Seq_MCF-7_Human1.11834800
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.11282398
76E2F1_20622854_ChIP-Seq_HELA_Human1.09892372
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.09122063
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08401421
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.07028441
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06799363
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02832447
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01126701
83SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00609639
84P300_27268052_Chip-Seq_Bcells_Human1.00509200
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00481036
86CTCF_26484167_Chip-Seq_Bcells_Mouse0.99705013
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99043392
88NCOR1_26117541_ChIP-Seq_K562_Human0.97997301
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97906153
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97738238
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97166219
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96948940
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96540154
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96408068
95STAT1_20625510_ChIP-Seq_HELA_Human0.94591338
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93894516
97FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93768879
98STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93403020
99CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93402124
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.93209600

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.95220477
2MP0005671_abnormal_response_to3.45559830
3MP0003763_abnormal_thymus_physiology3.35987706
4MP0000685_abnormal_immune_system3.29133631
5MP0001835_abnormal_antigen_presentation2.95788877
6MP0002139_abnormal_hepatobiliary_system2.83055382
7MP0005387_immune_system_phenotype2.77067760
8MP0001790_abnormal_immune_system2.77067760
9MP0001800_abnormal_humoral_immune2.72151915
10MP0003436_decreased_susceptibility_to2.58252774
11MP0005000_abnormal_immune_tolerance2.54144158
12MP0002166_altered_tumor_susceptibility2.49039132
13MP0004381_abnormal_hair_follicle2.41734973
14MP0002396_abnormal_hematopoietic_system2.36913441
15MP0004510_myositis2.19990621
16MP0002723_abnormal_immune_serum2.15657771
17MP0010155_abnormal_intestine_physiology2.11029335
18MP0003724_increased_susceptibility_to2.05036651
19MP0002148_abnormal_hypersensitivity_rea2.03913843
20MP0005025_abnormal_response_to1.99940364
21MP0009333_abnormal_splenocyte_physiolog1.97922409
22MP0002452_abnormal_antigen_presenting1.95773461
23MP0002420_abnormal_adaptive_immunity1.94229662
24MP0009785_altered_susceptibility_to1.92271076
25MP0001819_abnormal_immune_cell1.91232372
26MP0002006_tumorigenesis1.87497189
27MP0003303_peritoneal_inflammation1.84672617
28MP0002398_abnormal_bone_marrow1.84473674
29MP0001666_abnormal_nutrient_absorption1.83671466
30MP0000716_abnormal_immune_system1.71349238
31MP0009379_abnormal_foot_pigmentation1.70614914
32MP0001873_stomach_inflammation1.67392638
33MP0002138_abnormal_hepatobiliary_system1.62082169
34MP0000703_abnormal_thymus_morphology1.57095700
35MP0002419_abnormal_innate_immunity1.55375110
36MP0005085_abnormal_gallbladder_physiolo1.51434865
37MP0001845_abnormal_inflammatory_respons1.50857767
38MP0003183_abnormal_peptide_metabolism1.49561302
39MP0005451_abnormal_body_composition1.49136717
40MP0002405_respiratory_system_inflammati1.48495415
41MP0000490_abnormal_crypts_of1.40811414
42MP0003806_abnormal_nucleotide_metabolis1.39989146
43MP0009840_abnormal_foam_cell1.39586835
44MP0002429_abnormal_blood_cell1.38463399
45MP0004947_skin_inflammation1.34128228
46MP0002722_abnormal_immune_system1.33807857
47MP0009643_abnormal_urine_homeostasis1.31945825
48MP0002132_abnormal_respiratory_system1.30425735
49MP0008469_abnormal_protein_level1.30095717
50MP0004019_abnormal_vitamin_homeostasis1.28420545
51MP0002009_preneoplasia1.27936113
52MP0000689_abnormal_spleen_morphology1.26248495
53MP0005365_abnormal_bile_salt1.25741702
54MP0003252_abnormal_bile_duct1.20790288
55MP0002876_abnormal_thyroid_physiology1.16851201
56MP0000013_abnormal_adipose_tissue1.14468837
57MP0002163_abnormal_gland_morphology1.11376087
58MP0003866_abnormal_defecation1.09343306
59MP0000003_abnormal_adipose_tissue1.05745257
60MP0003075_altered_response_to1.05542321
61MP0001533_abnormal_skeleton_physiology1.05001337
62MP0005166_decreased_susceptibility_to1.02394242
63MP0005332_abnormal_amino_acid0.99121672
64MP0003300_gastrointestinal_ulcer0.98781948
65MP0001545_abnormal_hematopoietic_system0.95244652
66MP0005397_hematopoietic_system_phenotyp0.95244652
67MP0003705_abnormal_hypodermis_morpholog0.94770156
68MP0001853_heart_inflammation0.94707058
69MP0008057_abnormal_DNA_replication0.94629925
70MP0003693_abnormal_embryo_hatching0.94457123
71MP0002998_abnormal_bone_remodeling0.90008905
72MP0002136_abnormal_kidney_physiology0.89832673
73MP0003045_fibrosis0.89740403
74MP0005310_abnormal_salivary_gland0.89313974
75MP0000249_abnormal_blood_vessel0.89299173
76MP0009115_abnormal_fat_cell0.88310404
77MP0006036_abnormal_mitochondrial_physio0.86469913
78MP0005375_adipose_tissue_phenotype0.85731856
79MP0000609_abnormal_liver_physiology0.84779966
80MP0005666_abnormal_adipose_tissue0.83837821
81MP0003868_abnormal_feces_composition0.82632559
82MP0006138_congestive_heart_failure0.81424644
83MP0004808_abnormal_hematopoietic_stem0.80986330
84MP0002933_joint_inflammation0.80892452
85MP0005584_abnormal_enzyme/coenzyme_acti0.80092337
86MP0008872_abnormal_physiological_respon0.79684419
87MP0006082_CNS_inflammation0.79247014
88MP0001661_extended_life_span0.78549003
89MP0009764_decreased_sensitivity_to0.76968069
90MP0008874_decreased_physiological_sensi0.76318663
91MP0002693_abnormal_pancreas_physiology0.75857119
92MP0005645_abnormal_hypothalamus_physiol0.75334092
93MP0005334_abnormal_fat_pad0.74673562
94MP0005448_abnormal_energy_balance0.72717330
95MP0000858_altered_metastatic_potential0.71994144
96MP0002118_abnormal_lipid_homeostasis0.71604758
97MP0005409_darkened_coat_color0.71190321
98MP0009763_increased_sensitivity_to0.69891175
99MP0002796_impaired_skin_barrier0.69759139
100MP0002971_abnormal_brown_adipose0.68527042

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)5.24910541
2Abnormality of glutamine family amino acid metabolism (HP:0010902)4.40098644
3Malnutrition (HP:0004395)4.22715430
4Gastrointestinal stroma tumor (HP:0100723)4.06116868
5Eczematoid dermatitis (HP:0000976)3.56308766
6Panhypogammaglobulinemia (HP:0003139)3.54545489
7Meningitis (HP:0001287)3.48320734
8Recurrent fungal infections (HP:0002841)3.35174674
9Severe combined immunodeficiency (HP:0004430)3.31094144
10Recurrent viral infections (HP:0004429)3.30457407
11Autoimmune thrombocytopenia (HP:0001973)3.07011614
12Lymphopenia (HP:0001888)3.06172547
13Chronic diarrhea (HP:0002028)3.04818524
14Vasculitis (HP:0002633)3.03893098
15IgA deficiency (HP:0002720)3.03517266
16Emphysema (HP:0002097)3.03398302
17Combined immunodeficiency (HP:0005387)2.97472064
18IgG deficiency (HP:0004315)2.92193705
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.86136852
20Abnormality of B cell number (HP:0010975)2.84123566
21B lymphocytopenia (HP:0010976)2.82068483
22Encephalitis (HP:0002383)2.78548272
23Petechiae (HP:0000967)2.77531100
24Abnormality of monocarboxylic acid metabolism (HP:0010996)2.74754868
25Pustule (HP:0200039)2.73652262
26Abnormality of cells of the lymphoid lineage (HP:0012140)2.72772590
27Broad face (HP:0000283)2.70038873
28Recurrent bacterial skin infections (HP:0005406)2.69147097
29Agammaglobulinemia (HP:0004432)2.69133057
30Abnormality of T cell physiology (HP:0011840)2.63102489
31Oral leukoplakia (HP:0002745)2.56494382
32Alkalosis (HP:0001948)2.54510191
33Abnormality of T cells (HP:0002843)2.48546691
34Myositis (HP:0100614)2.46821537
35Abnormality of macrophages (HP:0004311)2.42232515
36Recurrent abscess formation (HP:0002722)2.37970452
37Mediastinal lymphadenopathy (HP:0100721)2.37032217
38Recurrent bronchitis (HP:0002837)2.34633981
39Increased IgM level (HP:0003496)2.33667372
40Hypergammaglobulinemia (HP:0010702)2.33538722
41Hyperlipoproteinemia (HP:0010980)2.33007730
42Pulmonary infiltrates (HP:0002113)2.32391539
43Systemic lupus erythematosus (HP:0002725)2.31888088
44Orchitis (HP:0100796)2.30752180
45Keratoconjunctivitis sicca (HP:0001097)2.22428520
46Chronic obstructive pulmonary disease (HP:0006510)2.21998129
47Obstructive lung disease (HP:0006536)2.21998129
48Optic neuritis (HP:0100653)2.21600904
49Retrobulbar optic neuritis (HP:0100654)2.21600904
50IgM deficiency (HP:0002850)2.21452465
51Skin ulcer (HP:0200042)2.18398179
52Abnormality of pyrimidine metabolism (HP:0004353)2.17919047
53Recurrent cutaneous fungal infections (HP:0011370)2.17897083
54Chronic mucocutaneous candidiasis (HP:0002728)2.17897083
55Lymphoma (HP:0002665)2.14250732
56Granulocytopenia (HP:0001913)2.08389373
57Urticaria (HP:0001025)2.07736591
58Prolonged bleeding time (HP:0003010)2.05140695
59Hydroxyprolinuria (HP:0003080)2.05039022
60Abnormality of proline metabolism (HP:0010907)2.05039022
61Fatigue (HP:0012378)2.04929077
62Spontaneous hematomas (HP:0007420)2.04710558
63Amaurosis fugax (HP:0100576)2.03599957
64Macrocytic anemia (HP:0001972)2.03427554
65Papilloma (HP:0012740)2.03229705
66Verrucae (HP:0200043)2.03229705
67Bone cyst (HP:0012062)2.02364619
68Hyperparathyroidism (HP:0000843)2.01345201
69Cellulitis (HP:0100658)2.00023017
70Hypertensive crisis (HP:0100735)1.99766151
71Autoimmune hemolytic anemia (HP:0001890)1.98668705
72Keratoconjunctivitis (HP:0001096)1.98199780
73Restrictive lung disease (HP:0002091)1.97845424
74Colitis (HP:0002583)1.97061901
75Hypophosphatemia (HP:0002148)1.96477144
76Metabolic alkalosis (HP:0200114)1.96408082
77T lymphocytopenia (HP:0005403)1.96084268
78Aplasia cutis congenita (HP:0001057)1.94786387
79Abnormality of T cell number (HP:0011839)1.92714360
80Gastrointestinal infarctions (HP:0005244)1.89240188
81Recurrent lower respiratory tract infections (HP:0002783)1.89141234
82Hypercortisolism (HP:0001578)1.88803400
83Pseudobulbar signs (HP:0002200)1.87747798
84Recurrent skin infections (HP:0001581)1.87679227
85Recurrent gram-negative bacterial infections (HP:0005420)1.86580598
86Abnormality of the pleura (HP:0002103)1.86485561
87Duplicated collecting system (HP:0000081)1.85900034
88Elevated erythrocyte sedimentation rate (HP:0003565)1.84989229
89Inflammation of the large intestine (HP:0002037)1.83753954
90Gastrointestinal inflammation (HP:0004386)1.83052802
91Axonal loss (HP:0003447)1.80640935
92Hypertriglyceridemia (HP:0002155)1.80368724
93Hypercalcemia (HP:0003072)1.80299984
94Exocrine pancreatic insufficiency (HP:0001738)1.78538056
95Papilledema (HP:0001085)1.76658678
96Gangrene (HP:0100758)1.76572615
97Hemoptysis (HP:0002105)1.74701962
98Nausea (HP:0002018)1.74682011
99Recurrent sinusitis (HP:0011108)1.74373011
100Chest pain (HP:0100749)1.74080673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.72611797
2MAP4K13.63987511
3PRPF4B3.60922516
4RIPK43.60526893
5TAOK33.45094275
6ERN12.76276980
7SIK22.43041196
8NLK2.30383102
9MST1R2.14620795
10PDK22.12920222
11BLK2.12468063
12MAP3K101.86602066
13SMG11.82578841
14MAPK121.70283129
15SYK1.69517992
16MAPK111.69358256
17CSK1.54981643
18TBK11.53432671
19MAP3K141.50201711
20VRK21.50050534
21BRD41.50048689
22MAP3K71.47182155
23ACVR1B1.43508147
24CDC42BPA1.39880477
25TYK21.36804031
26NME11.35699166
27CDK41.32060508
28HIPK21.30678316
29MAPK71.24983615
30BTK1.24849733
31TNK21.23005735
32KIT1.19310577
33MAP3K131.18192059
34IRAK41.11135808
35IKBKE1.10785013
36NEK91.08841202
37BMPR21.08816794
38MAPK41.05191308
39IKBKB1.03833444
40TXK0.94830548
41SIK10.94708288
42LYN0.88730707
43JAK30.88427389
44ZAP700.87821312
45ALK0.86594855
46GRK60.86244903
47TAOK20.85713952
48MAPKAPK50.85577715
49MAP3K10.85156913
50CDK70.85004143
51MARK20.83197370
52ITK0.83169410
53RIPK10.82421174
54EPHB10.79817756
55ICK0.79579238
56CDC70.78118130
57MAP2K20.77231259
58TAF10.76236843
59CSF1R0.76083367
60PRKCQ0.73658326
61LCK0.72671541
62HCK0.72523249
63TESK20.71819369
64MELK0.71625460
65FGFR40.70475214
66PIM10.67320960
67PASK0.66471232
68MAPKAPK30.66289772
69JAK10.63129206
70DMPK0.61713538
71TRPM70.61589681
72TEC0.59677630
73FES0.55073491
74TAOK10.54827357
75TESK10.54640743
76CAMKK20.53589589
77MTOR0.53412603
78CDK80.51334129
79NME20.49829317
80MATK0.46336668
81PDK10.45689416
82PDPK10.44758305
83FGFR30.44563138
84TYRO30.44161673
85DDR20.41450948
86STK40.40568528
87CHUK0.36476291
88CDK60.36276966
89MAPK30.36264667
90STK100.34250983
91FYN0.33935566
92MARK30.33653707
93MAPKAPK20.33366278
94JAK20.33030044
95KDR0.32557830
96CDK90.32500352
97CAMKK10.32046016
98PDGFRB0.30895806
99PTK60.30715536
100TNIK0.30640748

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046724.01849338
2Allograft rejection_Homo sapiens_hsa053303.97233602
3Primary immunodeficiency_Homo sapiens_hsa053403.88544308
4Autoimmune thyroid disease_Homo sapiens_hsa053203.81808688
5Graft-versus-host disease_Homo sapiens_hsa053323.57673588
6Asthma_Homo sapiens_hsa053103.57152563
7Type I diabetes mellitus_Homo sapiens_hsa049403.21383439
8Staphylococcus aureus infection_Homo sapiens_hsa051502.49303931
9Viral myocarditis_Homo sapiens_hsa054162.34132589
10Antigen processing and presentation_Homo sapiens_hsa046122.32713543
11Leishmaniasis_Homo sapiens_hsa051402.04605239
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99817258
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.90906760
14Hematopoietic cell lineage_Homo sapiens_hsa046401.75929809
15B cell receptor signaling pathway_Homo sapiens_hsa046621.69964247
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.63494839
17Vitamin digestion and absorption_Homo sapiens_hsa049771.57630337
18Herpes simplex infection_Homo sapiens_hsa051681.44849046
19Notch signaling pathway_Homo sapiens_hsa043301.42900570
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42037746
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.40792798
22Influenza A_Homo sapiens_hsa051641.30266471
23Toxoplasmosis_Homo sapiens_hsa051451.26431305
24Measles_Homo sapiens_hsa051621.26215946
25T cell receptor signaling pathway_Homo sapiens_hsa046601.24788926
26Chemical carcinogenesis_Homo sapiens_hsa052041.21047191
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20100583
28Renin-angiotensin system_Homo sapiens_hsa046141.09761564
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09120988
30Rheumatoid arthritis_Homo sapiens_hsa053231.07609643
31Bile secretion_Homo sapiens_hsa049761.07441379
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07032042
33Linoleic acid metabolism_Homo sapiens_hsa005911.06615919
34Fat digestion and absorption_Homo sapiens_hsa049751.00654337
35Osteoclast differentiation_Homo sapiens_hsa043801.00633262
36Caffeine metabolism_Homo sapiens_hsa002320.98106107
37Dorso-ventral axis formation_Homo sapiens_hsa043200.90467048
38Arachidonic acid metabolism_Homo sapiens_hsa005900.89559259
39Retinol metabolism_Homo sapiens_hsa008300.86940881
40Tuberculosis_Homo sapiens_hsa051520.83349076
41Acute myeloid leukemia_Homo sapiens_hsa052210.82936043
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81068084
43PPAR signaling pathway_Homo sapiens_hsa033200.79032110
44Epstein-Barr virus infection_Homo sapiens_hsa051690.75690652
45Non-small cell lung cancer_Homo sapiens_hsa052230.75644869
46Chemokine signaling pathway_Homo sapiens_hsa040620.75070353
47Mineral absorption_Homo sapiens_hsa049780.74716812
48HTLV-I infection_Homo sapiens_hsa051660.73343587
49Histidine metabolism_Homo sapiens_hsa003400.72252644
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.70155603
51Thyroid cancer_Homo sapiens_hsa052160.69589872
52Arginine biosynthesis_Homo sapiens_hsa002200.67304444
53TNF signaling pathway_Homo sapiens_hsa046680.67202981
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66246894
55Ribosome_Homo sapiens_hsa030100.64648405
56Prion diseases_Homo sapiens_hsa050200.63318833
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58608457
58Small cell lung cancer_Homo sapiens_hsa052220.57664305
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57631118
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57045227
61Tryptophan metabolism_Homo sapiens_hsa003800.56900112
62Complement and coagulation cascades_Homo sapiens_hsa046100.56488006
63Hepatitis B_Homo sapiens_hsa051610.55777265
64Hepatitis C_Homo sapiens_hsa051600.53713105
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53625983
66Phenylalanine metabolism_Homo sapiens_hsa003600.53146842
67African trypanosomiasis_Homo sapiens_hsa051430.53084111
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.50344330
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49553737
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48961161
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.48724134
72Viral carcinogenesis_Homo sapiens_hsa052030.47963793
73Pertussis_Homo sapiens_hsa051330.45873798
74Fructose and mannose metabolism_Homo sapiens_hsa000510.45365317
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44933427
76Glycerolipid metabolism_Homo sapiens_hsa005610.44772542
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44256873
78Fatty acid degradation_Homo sapiens_hsa000710.43905482
79Apoptosis_Homo sapiens_hsa042100.42903517
80Insulin resistance_Homo sapiens_hsa049310.42281439
81Starch and sucrose metabolism_Homo sapiens_hsa005000.42250695
82Systemic lupus erythematosus_Homo sapiens_hsa053220.41932264
83Insulin secretion_Homo sapiens_hsa049110.40372085
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.38902490
85Protein digestion and absorption_Homo sapiens_hsa049740.38265561
86Renin secretion_Homo sapiens_hsa049240.37898831
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37880550
88Chronic myeloid leukemia_Homo sapiens_hsa052200.37201936
89GnRH signaling pathway_Homo sapiens_hsa049120.36939393
90Salmonella infection_Homo sapiens_hsa051320.35232103
91Platelet activation_Homo sapiens_hsa046110.34760417
92Glutathione metabolism_Homo sapiens_hsa004800.33596197
93Sulfur relay system_Homo sapiens_hsa041220.32403910
94Pancreatic cancer_Homo sapiens_hsa052120.32223182
95Prostate cancer_Homo sapiens_hsa052150.31813462
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29428198
97Bladder cancer_Homo sapiens_hsa052190.26166544
98Pancreatic secretion_Homo sapiens_hsa049720.24110601
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23862432
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23366967

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »