MTCO1P40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.84223217
2ATP synthesis coupled proton transport (GO:0015986)7.05453216
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.05453216
4cytidine metabolic process (GO:0046087)5.86755956
5cytidine catabolic process (GO:0006216)5.86755956
6cytidine deamination (GO:0009972)5.86755956
7DNA deamination (GO:0045006)5.27017024
8respiratory electron transport chain (GO:0022904)5.17074455
9electron transport chain (GO:0022900)5.11112656
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.07567851
11pyrimidine ribonucleoside catabolic process (GO:0046133)5.06248716
12sulfation (GO:0051923)4.52766464
13ATP biosynthetic process (GO:0006754)4.31351802
14respiratory chain complex IV assembly (GO:0008535)4.14780520
15hydrogen ion transmembrane transport (GO:1902600)4.09783910
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.01365286
17viral transcription (GO:0019083)3.86570695
18parturition (GO:0007567)3.82598645
19protein complex biogenesis (GO:0070271)3.77009918
20proton transport (GO:0015992)3.74804512
21cytochrome complex assembly (GO:0017004)3.71320808
22translational termination (GO:0006415)3.68813902
23hydrogen transport (GO:0006818)3.67152182
24purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.54051274
25purine nucleoside triphosphate biosynthetic process (GO:0009145)3.50000617
26protein targeting to ER (GO:0045047)3.45080007
27mitochondrial respiratory chain complex assembly (GO:0033108)3.43856107
28cotranslational protein targeting to membrane (GO:0006613)3.40781561
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39249453
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.32066012
31NADH dehydrogenase complex assembly (GO:0010257)3.32066012
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.32066012
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26818782
34water-soluble vitamin biosynthetic process (GO:0042364)3.23564715
35protein localization to endoplasmic reticulum (GO:0070972)3.22668912
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21461759
37DNA demethylation (GO:0080111)3.18635309
38oxidative phosphorylation (GO:0006119)3.14805232
39positive regulation of prostaglandin secretion (GO:0032308)3.12886465
40immunoglobulin mediated immune response (GO:0016064)3.09447308
41positive regulation of respiratory burst (GO:0060267)3.09027792
42fucose catabolic process (GO:0019317)3.06871452
43L-fucose metabolic process (GO:0042354)3.06871452
44L-fucose catabolic process (GO:0042355)3.06871452
45indole-containing compound catabolic process (GO:0042436)3.04756709
46indolalkylamine catabolic process (GO:0046218)3.04756709
47tryptophan catabolic process (GO:0006569)3.04756709
48protein neddylation (GO:0045116)3.03874578
49ribosomal small subunit assembly (GO:0000028)3.02095106
50N-acetylglucosamine metabolic process (GO:0006044)2.99244914
51positive regulation of protein homodimerization activity (GO:0090073)2.99055606
52negative regulation of mast cell activation (GO:0033004)2.93334520
53translational elongation (GO:0006414)2.91889426
54cellular response to zinc ion (GO:0071294)2.88058894
55kynurenine metabolic process (GO:0070189)2.86844971
56behavioral response to nicotine (GO:0035095)2.85018319
57ribonucleoside triphosphate biosynthetic process (GO:0009201)2.83917029
58viral life cycle (GO:0019058)2.78025260
59regulation of guanylate cyclase activity (GO:0031282)2.75212945
60microglial cell activation (GO:0001774)2.71685316
61mast cell activation (GO:0045576)2.69936534
62ribosomal small subunit biogenesis (GO:0042274)2.69240109
63regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64210268
64platelet dense granule organization (GO:0060155)2.63340161
65cellular protein complex disassembly (GO:0043624)2.62822149
66neuron fate determination (GO:0048664)2.59504907
67aerobic respiration (GO:0009060)2.59497421
68chaperone-mediated protein transport (GO:0072321)2.59480865
69indolalkylamine metabolic process (GO:0006586)2.53307580
70positive regulation of fatty acid transport (GO:2000193)2.52315638
71B cell mediated immunity (GO:0019724)2.49892300
72regulation of prostaglandin secretion (GO:0032306)2.48956303
73regulation of hypersensitivity (GO:0002883)2.47316298
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46085836
75tryptophan metabolic process (GO:0006568)2.44306416
76protein-cofactor linkage (GO:0018065)2.44168568
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.44020413
78positive regulation of T cell migration (GO:2000406)2.43069508
79fat-soluble vitamin catabolic process (GO:0042363)2.42603130
80vitamin catabolic process (GO:0009111)2.42603130
81pyrimidine nucleoside catabolic process (GO:0046135)2.42412311
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.41946547
83positive regulation of icosanoid secretion (GO:0032305)2.41640071
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.40913750
85positive regulation of lymphocyte migration (GO:2000403)2.40217218
86negative regulation of telomere maintenance (GO:0032205)2.40031524
87DNA dealkylation (GO:0035510)2.39603644
88eosinophil chemotaxis (GO:0048245)2.37050505
89nucleoside triphosphate biosynthetic process (GO:0009142)2.35603940
90interferon-gamma-mediated signaling pathway (GO:0060333)2.34679423
91positive regulation of calcium-mediated signaling (GO:0050850)2.33865621
92vitamin biosynthetic process (GO:0009110)2.33458230
93intracellular protein transmembrane import (GO:0044743)2.32243436
94nephron tubule morphogenesis (GO:0072078)2.31447832
95nephron epithelium morphogenesis (GO:0072088)2.31447832
96positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.30628580
97translational initiation (GO:0006413)2.29324741
98positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.29185347
99response to interferon-beta (GO:0035456)2.28183893
100positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.28011691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.31084254
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.27786553
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.00872680
4VDR_22108803_ChIP-Seq_LS180_Human2.89388067
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.76074668
6EZH2_22144423_ChIP-Seq_EOC_Human2.71813415
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.61914586
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.55955963
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41745489
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28244345
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25600615
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.24323220
13ZNF274_21170338_ChIP-Seq_K562_Hela2.21337196
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.11393241
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91293152
16IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90056047
17NOTCH1_21737748_ChIP-Seq_TLL_Human1.86071283
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82408109
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70529079
20BCAT_22108803_ChIP-Seq_LS180_Human1.70466964
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69518546
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65844181
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.63873524
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63592631
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60632951
26EWS_26573619_Chip-Seq_HEK293_Human1.60353362
27FOXA1_27270436_Chip-Seq_PROSTATE_Human1.60135783
28FOXA1_25329375_ChIP-Seq_VCAP_Human1.60135783
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57746110
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52464230
31FUS_26573619_Chip-Seq_HEK293_Human1.51916890
32VDR_23849224_ChIP-Seq_CD4+_Human1.50367404
33IGF1R_20145208_ChIP-Seq_DFB_Human1.48270414
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44697599
35AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43659409
36AR_20517297_ChIP-Seq_VCAP_Human1.41721440
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41281803
38IRF1_19129219_ChIP-ChIP_H3396_Human1.40583396
39ERG_20517297_ChIP-Seq_VCAP_Human1.39624584
40FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36886427
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36655583
42MYC_18940864_ChIP-ChIP_HL60_Human1.36447536
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.35668525
44GATA3_26560356_Chip-Seq_TH2_Human1.35166427
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34919585
46ELK1_19687146_ChIP-ChIP_HELA_Human1.34821224
47NCOR_22424771_ChIP-Seq_293T_Human1.34806866
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.34175933
49HTT_18923047_ChIP-ChIP_STHdh_Human1.33870486
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32185253
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30105608
52TP53_22573176_ChIP-Seq_HFKS_Human1.29932185
53NANOG_20526341_ChIP-Seq_ESCs_Human1.29471601
54STAT1_20625510_ChIP-Seq_HELA_Human1.29120161
55ER_23166858_ChIP-Seq_MCF-7_Human1.27490659
56SOX2_19829295_ChIP-Seq_ESCs_Human1.26732618
57NANOG_19829295_ChIP-Seq_ESCs_Human1.26732618
58P300_19829295_ChIP-Seq_ESCs_Human1.26135698
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24717925
60TAF2_19829295_ChIP-Seq_ESCs_Human1.24011288
61MYC_19829295_ChIP-Seq_ESCs_Human1.23334880
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22995916
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19244136
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19104989
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.16260455
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15998727
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15800340
68AR_25329375_ChIP-Seq_VCAP_Human1.15062810
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10702536
70CBP_20019798_ChIP-Seq_JUKART_Human1.09969908
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09969908
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09062995
73GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08649207
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08383657
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.08195463
76RUNX_20019798_ChIP-Seq_JUKART_Human1.08013428
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.07386792
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07102730
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06567491
80GATA3_26560356_Chip-Seq_TH1_Human1.06121496
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05376103
82FOXP3_21729870_ChIP-Seq_TREG_Human1.02147295
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99757580
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98945648
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98910209
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98079120
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96892737
88ERA_21632823_ChIP-Seq_H3396_Human0.96383919
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.96364738
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.94138148
91CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93783930
92RBPJ_21746931_ChIP-Seq_IB4_Human0.92697626
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91656888
94PHF8_20622853_ChIP-Seq_HELA_Human0.91626880
95REST_21632747_ChIP-Seq_MESCs_Mouse0.91506318
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.91455123
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90922543
98CDX2_22108803_ChIP-Seq_LS180_Human0.90444836
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.89753990
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88551616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.16259710
2MP0005671_abnormal_response_to3.37833287
3MP0002139_abnormal_hepatobiliary_system2.72326675
4MP0001835_abnormal_antigen_presentation2.63303828
5MP0005645_abnormal_hypothalamus_physiol2.52640369
6MP0002277_abnormal_respiratory_mucosa2.51169296
7MP0002876_abnormal_thyroid_physiology2.33728154
8MP0005360_urolithiasis2.23833700
9MP0002163_abnormal_gland_morphology2.18596688
10MP0001873_stomach_inflammation2.12708513
11MP0000685_abnormal_immune_system2.09912457
12MP0009785_altered_susceptibility_to2.04624364
13MP0004019_abnormal_vitamin_homeostasis2.01848553
14MP0001800_abnormal_humoral_immune1.99905136
15MP0002138_abnormal_hepatobiliary_system1.98281237
16MP0005387_immune_system_phenotype1.97798292
17MP0001790_abnormal_immune_system1.97798292
18MP0002166_altered_tumor_susceptibility1.87299809
19MP0003724_increased_susceptibility_to1.83772253
20MP0003806_abnormal_nucleotide_metabolis1.82008548
21MP0004885_abnormal_endolymph1.80591506
22MP0002148_abnormal_hypersensitivity_rea1.79347671
23MP0008872_abnormal_physiological_respon1.79073126
24MP0006072_abnormal_retinal_apoptosis1.77610630
25MP0005000_abnormal_immune_tolerance1.74251008
26MP0005379_endocrine/exocrine_gland_phen1.63772418
27MP0004043_abnormal_pH_regulation1.53503957
28MP0002723_abnormal_immune_serum1.52262370
29MP0001765_abnormal_ion_homeostasis1.51733602
30MP0010155_abnormal_intestine_physiology1.51275944
31MP0005332_abnormal_amino_acid1.51097706
32MP0001485_abnormal_pinna_reflex1.49000095
33MP0002837_dystrophic_cardiac_calcinosis1.48983409
34MP0002006_tumorigenesis1.48301902
35MP0002452_abnormal_antigen_presenting1.45595892
36MP0009333_abnormal_splenocyte_physiolog1.45443354
37MP0008877_abnormal_DNA_methylation1.43881345
38MP0005085_abnormal_gallbladder_physiolo1.38111295
39MP0008875_abnormal_xenobiotic_pharmacok1.37628167
40MP0006036_abnormal_mitochondrial_physio1.37550439
41MP0004142_abnormal_muscle_tone1.35975514
42MP0003866_abnormal_defecation1.34552602
43MP0003183_abnormal_peptide_metabolism1.30712903
44MP0003252_abnormal_bile_duct1.29680726
45MP0005365_abnormal_bile_salt1.28610839
46MP0002693_abnormal_pancreas_physiology1.28600315
47MP0001819_abnormal_immune_cell1.27177704
48MP0005551_abnormal_eye_electrophysiolog1.27146014
49MP0002420_abnormal_adaptive_immunity1.26898003
50MP0002638_abnormal_pupillary_reflex1.26763589
51MP0002272_abnormal_nervous_system1.26485764
52MP0001666_abnormal_nutrient_absorption1.26154056
53MP0000230_abnormal_systemic_arterial1.25080451
54MP0005025_abnormal_response_to1.24534740
55MP0003195_calcinosis1.24150081
56MP0003283_abnormal_digestive_organ1.23843412
57MP0001845_abnormal_inflammatory_respons1.22305799
58MP0002733_abnormal_thermal_nociception1.22214639
59MP0009643_abnormal_urine_homeostasis1.21307812
60MP0002653_abnormal_ependyma_morphology1.21038171
61MP0001970_abnormal_pain_threshold1.20038249
62MP0005084_abnormal_gallbladder_morpholo1.15966496
63MP0003011_delayed_dark_adaptation1.15041985
64MP0001905_abnormal_dopamine_level1.13346744
65MP0009764_decreased_sensitivity_to1.12815508
66MP0009745_abnormal_behavioral_response1.12751230
67MP0004145_abnormal_muscle_electrophysio1.12426962
68MP0005448_abnormal_energy_balance1.11792160
69MP0001663_abnormal_digestive_system1.11049490
70MP0006082_CNS_inflammation1.10241572
71MP0001188_hyperpigmentation1.09081567
72MP0010386_abnormal_urinary_bladder1.07171775
73MP0002909_abnormal_adrenal_gland1.05198457
74MP0008469_abnormal_protein_level1.03787097
75MP0005636_abnormal_mineral_homeostasis1.02232047
76MP0004215_abnormal_myocardial_fiber1.01490040
77MP0010329_abnormal_lipoprotein_level0.99731201
78MP0005174_abnormal_tail_pigmentation0.96932466
79MP0001986_abnormal_taste_sensitivity0.95896449
80MP0000716_abnormal_immune_system0.95867752
81MP0000631_abnormal_neuroendocrine_gland0.95101492
82MP0001968_abnormal_touch/_nociception0.94167527
83MP0009046_muscle_twitch0.92584764
84MP0002136_abnormal_kidney_physiology0.92492297
85MP0005389_reproductive_system_phenotype0.91243096
86MP0005253_abnormal_eye_physiology0.90365865
87MP0001756_abnormal_urination0.87563058
88MP0002734_abnormal_mechanical_nocicepti0.84448955
89MP0002419_abnormal_innate_immunity0.84306018
90MP0005381_digestive/alimentary_phenotyp0.84066971
91MP0002095_abnormal_skin_pigmentation0.83766966
92MP0001440_abnormal_grooming_behavior0.82899888
93MP0005535_abnormal_body_temperature0.82024800
94MP0004270_analgesia0.81738248
95MP0001944_abnormal_pancreas_morphology0.79207878
96MP0003638_abnormal_response/metabolism_0.78941806
97MP0005310_abnormal_salivary_gland0.75498747
98MP0005166_decreased_susceptibility_to0.72613924
99MP0001664_abnormal_digestion0.72197170
100MP0001764_abnormal_homeostasis0.71778047

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.00744466
2Mitochondrial inheritance (HP:0001427)3.87286348
3Congenital, generalized hypertrichosis (HP:0004540)3.63519139
4Increased hepatocellular lipid droplets (HP:0006565)3.52836967
5Lipid accumulation in hepatocytes (HP:0006561)3.47846396
6Progressive macrocephaly (HP:0004481)3.46288068
7Abnormal mitochondria in muscle tissue (HP:0008316)3.38667916
8Increased CSF lactate (HP:0002490)3.29549557
9Acute encephalopathy (HP:0006846)3.23758011
10Hepatocellular necrosis (HP:0001404)3.08196007
11Large for gestational age (HP:0001520)3.05481385
12Congenital stationary night blindness (HP:0007642)3.04199549
13Abnormality of urine glucose concentration (HP:0011016)2.99106601
14Glycosuria (HP:0003076)2.99106601
15Macrocytic anemia (HP:0001972)2.97955911
16Abnormality of vitamin B metabolism (HP:0004340)2.89646073
17Hepatic necrosis (HP:0002605)2.85934169
18Abnormality of cells of the erythroid lineage (HP:0012130)2.77562093
19Renal Fanconi syndrome (HP:0001994)2.72810338
20Exertional dyspnea (HP:0002875)2.69448777
21Abnormality of renal resorption (HP:0011038)2.69088444
22Molar tooth sign on MRI (HP:0002419)2.66297737
23Abnormality of midbrain morphology (HP:0002418)2.66297737
24Septo-optic dysplasia (HP:0100842)2.65127691
25Abnormal number of erythroid precursors (HP:0012131)2.64227564
26Abnormality of the vitamin B12 metabolism (HP:0004341)2.64131012
27Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63642139
28Metabolic alkalosis (HP:0200114)2.61395551
29Cerebral edema (HP:0002181)2.60622122
30Abolished electroretinogram (ERG) (HP:0000550)2.59548750
31Pancreatic cysts (HP:0001737)2.54784291
32Methylmalonic aciduria (HP:0012120)2.54314856
33Abnormal rod and cone electroretinograms (HP:0008323)2.52988784
34Decreased circulating renin level (HP:0003351)2.51682336
35Pendular nystagmus (HP:0012043)2.51065926
36IgG deficiency (HP:0004315)2.50414611
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45318374
383-Methylglutaconic aciduria (HP:0003535)2.45160513
39Hyperphosphaturia (HP:0003109)2.40527240
40Stomatitis (HP:0010280)2.40293435
41Confusion (HP:0001289)2.39638531
42True hermaphroditism (HP:0010459)2.38677904
43Attenuation of retinal blood vessels (HP:0007843)2.37497315
44Abnormal urine phosphate concentration (HP:0012599)2.36102344
45Increased intramyocellular lipid droplets (HP:0012240)2.35222240
46Optic disc pallor (HP:0000543)2.33201479
47Methylmalonic acidemia (HP:0002912)2.28050503
48Pancreatic fibrosis (HP:0100732)2.23982154
49Abnormal albumin level (HP:0012116)2.19911160
50Hypoalbuminemia (HP:0003073)2.19911160
51Increased muscle lipid content (HP:0009058)2.16495138
52Chronic diarrhea (HP:0002028)2.12242879
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.10974868
54Lethargy (HP:0001254)2.09949670
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08696251
56Decreased central vision (HP:0007663)2.08260879
57Abnormality of vitamin metabolism (HP:0100508)2.05972582
58Abnormality of B cell number (HP:0010975)2.03867188
59Hyperinsulinemic hypoglycemia (HP:0000825)2.02976222
60Respiratory failure (HP:0002878)2.02824629
61Hydroxyprolinuria (HP:0003080)2.02212827
62Abnormality of proline metabolism (HP:0010907)2.02212827
63Lactic acidosis (HP:0003128)2.00898911
64Abnormality of renal excretion (HP:0011036)1.98818829
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97372531
66Reticulocytopenia (HP:0001896)1.97364782
67Furrowed tongue (HP:0000221)1.97059847
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96678023
69Alkalosis (HP:0001948)1.93341239
70Mesangial abnormality (HP:0001966)1.92760920
71Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92210068
72Abnormality of renin-angiotensin system (HP:0000847)1.92057912
73Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90829484
74Dicarboxylic aciduria (HP:0003215)1.90829484
75Elevated erythrocyte sedimentation rate (HP:0003565)1.90434229
76Abnormality of T cell physiology (HP:0011840)1.90348099
77Megaloblastic anemia (HP:0001889)1.89629160
78Conjunctival hamartoma (HP:0100780)1.89596159
79Bone cyst (HP:0012062)1.89251640
80Aplastic anemia (HP:0001915)1.88173058
81Facial shape deformation (HP:0011334)1.87611591
82Potter facies (HP:0002009)1.87611591
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86083280
84Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86083280
85Aplasia/hypoplasia of the uterus (HP:0008684)1.86021930
86Increased serum lactate (HP:0002151)1.84978855
87Recurrent bronchitis (HP:0002837)1.83386196
88Hypoglycemic coma (HP:0001325)1.83218582
89Posterior subcapsular cataract (HP:0007787)1.83204070
90Bony spicule pigmentary retinopathy (HP:0007737)1.80884809
91Hyperphosphatemia (HP:0002905)1.79336677
92Pallor (HP:0000980)1.77824919
93Nausea (HP:0002018)1.77737836
94Hypoglycemic seizures (HP:0002173)1.77142834
95Oral leukoplakia (HP:0002745)1.75853701
96Hyperglycinuria (HP:0003108)1.74152711
97Hypoplasia of the uterus (HP:0000013)1.73906269
98Hypothermia (HP:0002045)1.71089719
99Leukodystrophy (HP:0002415)1.69552876
100Metabolic acidosis (HP:0001942)1.68839241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK22.93952806
2MAP3K122.69897987
3GRK12.62367650
4ACVR1B2.61006261
5MAP4K12.57492259
6MST42.43706079
7MAPK152.28064562
8BMPR1B2.26194570
9TXK2.18543382
10TNIK2.17273996
11VRK22.14788488
12BMPR22.07654831
13FRK2.02325252
14PNCK2.01560586
15TAOK31.97432298
16CAMKK21.96890007
17TLK11.96266237
18NME11.94093160
19VRK11.88030503
20TAF11.85601100
21WNK31.79962078
22RIPK41.76932273
23ZAK1.75321271
24IKBKB1.50774680
25NLK1.48143590
26MAP2K61.45348159
27WNK41.44650668
28MAP4K21.40576160
29KIT1.38225680
30PINK11.37154769
31MATK1.29405150
32LYN1.22693896
33NUAK11.21887196
34DAPK21.21774289
35OXSR11.20459844
36SYK1.16269580
37MAP3K41.08463943
38IRAK41.06621746
39PRKCQ1.04384513
40CSK1.03853323
41STK241.00901938
42INSRR1.00742102
43STK160.99729881
44ITK0.99664808
45PRKCI0.94314941
46PAK30.86275202
47TEC0.86043208
48IKBKE0.83591106
49CDK190.83133498
50MYLK0.80614380
51BUB10.80484079
52KDR0.80469840
53WEE10.80445478
54CASK0.79915379
55PIK3CA0.77062460
56PRKCH0.76993626
57PRKCG0.76578390
58OBSCN0.75822276
59MAP2K20.71787041
60PRKG20.71724906
61PRKCE0.71380176
62STK38L0.68675607
63LCK0.64736103
64SIK20.63837936
65DYRK20.62908655
66PHKG10.60447057
67PHKG20.60447057
68CSNK1A10.59993634
69PASK0.59240562
70CAMK2D0.58730445
71TIE10.56769892
72PRKACA0.56526416
73DAPK10.52616294
74MAPK130.52006679
75BTK0.51213912
76ADRBK10.50382457
77PRKG10.49828324
78PRKCA0.48247715
79MUSK0.47946710
80PIM10.47056666
81CSF1R0.45487102
82PTK2B0.44038366
83IGF1R0.43913904
84TBK10.43451521
85STK390.43243841
86STK110.41149904
87MKNK20.41149662
88IRAK10.40040794
89CHUK0.38916853
90GRK60.38196932
91PRKCZ0.37188892
92CSNK2A20.37031270
93STK30.36942365
94CAMKK10.36393527
95CAMK2A0.36239108
96PRKCD0.36028173
97DAPK30.35173818
98CDK40.35147987
99CAMK1D0.34152390
100JAK10.33161679

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.88574090
2Asthma_Homo sapiens_hsa053103.64862587
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.37411045
4Allograft rejection_Homo sapiens_hsa053303.30198321
5Type I diabetes mellitus_Homo sapiens_hsa049403.18032267
6Graft-versus-host disease_Homo sapiens_hsa053323.16224213
7Parkinsons disease_Homo sapiens_hsa050123.07077996
8Autoimmune thyroid disease_Homo sapiens_hsa053203.06655113
9Ribosome_Homo sapiens_hsa030103.02335527
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.27369204
11Alzheimers disease_Homo sapiens_hsa050102.12986395
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06547222
13Cardiac muscle contraction_Homo sapiens_hsa042601.93624151
14Primary immunodeficiency_Homo sapiens_hsa053401.91310186
15Huntingtons disease_Homo sapiens_hsa050161.89193370
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78296017
17Antigen processing and presentation_Homo sapiens_hsa046121.77661004
18Protein export_Homo sapiens_hsa030601.74413034
19Rheumatoid arthritis_Homo sapiens_hsa053231.68365450
20Proteasome_Homo sapiens_hsa030501.61012380
21Vitamin digestion and absorption_Homo sapiens_hsa049771.57428318
22Caffeine metabolism_Homo sapiens_hsa002321.49190479
23Staphylococcus aureus infection_Homo sapiens_hsa051501.47643318
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40928241
25Linoleic acid metabolism_Homo sapiens_hsa005911.38412707
26Mineral absorption_Homo sapiens_hsa049781.35861843
27Tryptophan metabolism_Homo sapiens_hsa003801.35676101
28Sulfur metabolism_Homo sapiens_hsa009201.32600573
29Fat digestion and absorption_Homo sapiens_hsa049751.31894192
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31721855
31RNA polymerase_Homo sapiens_hsa030201.21921061
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21665556
33Chemical carcinogenesis_Homo sapiens_hsa052041.12775440
34Phototransduction_Homo sapiens_hsa047441.12515595
35Leishmaniasis_Homo sapiens_hsa051401.10239037
36Viral myocarditis_Homo sapiens_hsa054161.09374386
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06672270
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05524477
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02941519
40Folate biosynthesis_Homo sapiens_hsa007901.02590733
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.00360832
42Collecting duct acid secretion_Homo sapiens_hsa049660.99651660
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95956494
44Renin-angiotensin system_Homo sapiens_hsa046140.94062282
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.93674962
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93583310
47Sulfur relay system_Homo sapiens_hsa041220.89431497
48Hematopoietic cell lineage_Homo sapiens_hsa046400.86348887
49Glutathione metabolism_Homo sapiens_hsa004800.85537221
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83139017
51Arachidonic acid metabolism_Homo sapiens_hsa005900.78837695
52Butanoate metabolism_Homo sapiens_hsa006500.77797300
53Insulin secretion_Homo sapiens_hsa049110.77670670
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77114278
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75654386
56Nitrogen metabolism_Homo sapiens_hsa009100.75442975
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73086603
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71783663
59Peroxisome_Homo sapiens_hsa041460.70859511
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68136128
61Retinol metabolism_Homo sapiens_hsa008300.67544663
62Homologous recombination_Homo sapiens_hsa034400.63958756
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63724491
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63481873
65RNA degradation_Homo sapiens_hsa030180.61495984
66Ether lipid metabolism_Homo sapiens_hsa005650.60239757
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58805877
68One carbon pool by folate_Homo sapiens_hsa006700.54541259
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.53652924
70Histidine metabolism_Homo sapiens_hsa003400.53104546
71Glycerolipid metabolism_Homo sapiens_hsa005610.47846260
72Regulation of autophagy_Homo sapiens_hsa041400.46664556
73Tuberculosis_Homo sapiens_hsa051520.41415711
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40760126
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40107677
76Protein digestion and absorption_Homo sapiens_hsa049740.39285252
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.38505308
78Toxoplasmosis_Homo sapiens_hsa051450.36957497
79Purine metabolism_Homo sapiens_hsa002300.36590478
80Fatty acid degradation_Homo sapiens_hsa000710.36119349
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36008456
82Metabolic pathways_Homo sapiens_hsa011000.34289888
83Selenocompound metabolism_Homo sapiens_hsa004500.33605323
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33393167
85Taste transduction_Homo sapiens_hsa047420.32269292
86African trypanosomiasis_Homo sapiens_hsa051430.29078395
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27632684
88Renin secretion_Homo sapiens_hsa049240.27464667
89Pancreatic secretion_Homo sapiens_hsa049720.25884987
90Nicotine addiction_Homo sapiens_hsa050330.25709650
91Herpes simplex infection_Homo sapiens_hsa051680.25464733
92Basal transcription factors_Homo sapiens_hsa030220.25273648
93Serotonergic synapse_Homo sapiens_hsa047260.25166949
94Spliceosome_Homo sapiens_hsa030400.23653356
95Pertussis_Homo sapiens_hsa051330.23305105
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22856074
97Starch and sucrose metabolism_Homo sapiens_hsa005000.22269835
98Influenza A_Homo sapiens_hsa051640.22268533
99PPAR signaling pathway_Homo sapiens_hsa033200.22104452
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21904730

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