MTCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the upstream 13 kDa protein that is a member of the TCL1 family. This protein may be involved in leukemogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)7.08549045
2ribosomal small subunit biogenesis (GO:0042274)6.60044300
3DNA replication checkpoint (GO:0000076)5.81264670
4viral transcription (GO:0019083)5.63063899
5ribosomal small subunit assembly (GO:0000028)5.56066779
6translational termination (GO:0006415)5.44837288
7production of molecular mediator involved in inflammatory response (GO:0002532)5.42358281
8maturation of SSU-rRNA (GO:0030490)5.34625059
9positive regulation of gamma-delta T cell activation (GO:0046645)4.92128954
10ribosomal large subunit biogenesis (GO:0042273)4.83847649
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.67607267
12kinetochore organization (GO:0051383)4.67542369
13cotranslational protein targeting to membrane (GO:0006613)4.56837161
14protein targeting to ER (GO:0045047)4.50181532
15translational elongation (GO:0006414)4.47766020
16megakaryocyte development (GO:0035855)4.43477896
17protein neddylation (GO:0045116)4.42598648
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.31770012
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.31693272
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.31522454
21cullin deneddylation (GO:0010388)4.30463319
22protein localization to endoplasmic reticulum (GO:0070972)4.29713277
23heparin metabolic process (GO:0030202)4.23845109
24heparin biosynthetic process (GO:0030210)4.23845109
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21698830
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.19434095
27ATP synthesis coupled proton transport (GO:0015986)4.18770352
28energy coupled proton transport, down electrochemical gradient (GO:0015985)4.18770352
29establishment of protein localization to mitochondrial membrane (GO:0090151)4.15103864
30translational initiation (GO:0006413)4.12635074
31daunorubicin metabolic process (GO:0044597)4.08993750
32polyketide metabolic process (GO:0030638)4.08993750
33doxorubicin metabolic process (GO:0044598)4.08993750
34viral life cycle (GO:0019058)4.07257985
35chaperone-mediated protein transport (GO:0072321)4.05477497
36ribonucleoprotein complex biogenesis (GO:0022613)4.02985967
37cellular protein complex disassembly (GO:0043624)3.99598134
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.98038454
39proteasome assembly (GO:0043248)3.96594474
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.94757591
41cellular response to interferon-beta (GO:0035458)3.93086656
42regulation of gamma-delta T cell differentiation (GO:0045586)3.92454379
43chromatin remodeling at centromere (GO:0031055)3.88972100
44peptidyl-histidine modification (GO:0018202)3.88646247
45mitotic chromosome condensation (GO:0007076)3.86067448
46CENP-A containing nucleosome assembly (GO:0034080)3.83217599
47protein deneddylation (GO:0000338)3.81674287
48pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.80638332
49positive regulation of histone H3-K4 methylation (GO:0051571)3.76823025
50positive regulation of natural killer cell differentiation (GO:0032825)3.75235376
51B cell receptor signaling pathway (GO:0050853)3.74855139
52pyrimidine nucleotide catabolic process (GO:0006244)3.74217626
53respiratory electron transport chain (GO:0022904)3.68339194
54translation (GO:0006412)3.65049688
55positive regulation of B cell differentiation (GO:0045579)3.62747142
56electron transport chain (GO:0022900)3.58834740
57regulation of B cell receptor signaling pathway (GO:0050855)3.55399997
58interferon-gamma production (GO:0032609)3.53874723
59cellular component biogenesis (GO:0044085)3.53108864
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.50513544
61positive regulation of amino acid transport (GO:0051957)3.50223481
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.50167558
63NADH dehydrogenase complex assembly (GO:0010257)3.50167558
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50167558
65T cell homeostasis (GO:0043029)3.49333791
66embryonic hemopoiesis (GO:0035162)3.48639670
67replication fork processing (GO:0031297)3.41590320
68formation of translation preinitiation complex (GO:0001731)3.40475876
69regulation of gamma-delta T cell activation (GO:0046643)3.36508332
70regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.36150038
71negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.35894170
72GTP biosynthetic process (GO:0006183)3.34364572
73kinetochore assembly (GO:0051382)3.34020207
74necroptotic process (GO:0070266)3.33476768
75negative regulation of erythrocyte differentiation (GO:0045647)3.29358381
76protein complex biogenesis (GO:0070271)3.28875708
77protein targeting to mitochondrion (GO:0006626)3.28871972
78negative T cell selection (GO:0043383)3.27468552
79pteridine-containing compound biosynthetic process (GO:0042559)3.27051015
80telomere maintenance via semi-conservative replication (GO:0032201)3.26235967
81mast cell degranulation (GO:0043303)3.26016958
82mast cell activation involved in immune response (GO:0002279)3.26016958
83mast cell activation (GO:0045576)3.25878636
84outer ear morphogenesis (GO:0042473)3.25186110
85negative regulation of RNA splicing (GO:0033119)3.24954406
86histone H3-K4 trimethylation (GO:0080182)3.24686809
87positive regulation of granulocyte differentiation (GO:0030854)3.24526267
88lymphocyte homeostasis (GO:0002260)3.23817234
89oxidative phosphorylation (GO:0006119)3.23181550
90positive regulation of male gonad development (GO:2000020)3.22413124
91meiotic chromosome segregation (GO:0045132)3.21248704
92protein complex disassembly (GO:0043241)3.19062143
93negative thymic T cell selection (GO:0045060)3.18516178
94positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)3.16071556
95resolution of meiotic recombination intermediates (GO:0000712)3.15261816
96histone mRNA catabolic process (GO:0071044)3.12745477
97negative regulation of T-helper cell differentiation (GO:0045623)3.11857602
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.11857602
99mitochondrial respiratory chain complex assembly (GO:0033108)3.10235911
100hepatocyte apoptotic process (GO:0097284)3.09417106
101deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.07057920
102positive regulation of lipid kinase activity (GO:0090218)3.06827413
103thrombin receptor signaling pathway (GO:0070493)3.06803432
104negative regulation of amino acid transport (GO:0051956)3.06110369
105B cell homeostasis (GO:0001782)3.05582161
106UTP biosynthetic process (GO:0006228)3.05575650
107negative regulation of phagocytosis (GO:0050765)3.05519802
108DNA strand elongation involved in DNA replication (GO:0006271)3.05213590
109macromolecular complex disassembly (GO:0032984)3.05177398
110rRNA processing (GO:0006364)3.03244123
111lymphoid progenitor cell differentiation (GO:0002320)3.03148799
112negative regulation of neurotransmitter secretion (GO:0046929)3.02804912
113pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.02611859
114mitotic sister chromatid cohesion (GO:0007064)2.99976350
115response to pheromone (GO:0019236)2.99953858
116establishment of protein localization to mitochondrion (GO:0072655)2.98808473
117pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.96354135
118nuclear-transcribed mRNA catabolic process (GO:0000956)2.95937536
119chromosome organization involved in meiosis (GO:0070192)2.95883241
120muscle cell fate commitment (GO:0042693)2.95417118
121protoporphyrinogen IX metabolic process (GO:0046501)2.95175492
122regulation of mitochondrial translation (GO:0070129)2.95121903
123secretory granule organization (GO:0033363)2.94896541
124antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94448862
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94448862
126toxin transport (GO:1901998)2.93672436
127histone exchange (GO:0043486)2.93115639
128positive regulation of vascular permeability (GO:0043117)2.91184307
129deoxyribose phosphate biosynthetic process (GO:0046385)2.90728224
1302-deoxyribonucleotide biosynthetic process (GO:0009265)2.90728224
131rRNA metabolic process (GO:0016072)2.90424330
132protein localization to mitochondrion (GO:0070585)2.90333657
133DNA strand elongation (GO:0022616)2.90035100
134ribosome biogenesis (GO:0042254)2.89968096
135deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89895131
136regulation of response to tumor cell (GO:0002834)2.89810703
137positive regulation of response to tumor cell (GO:0002836)2.89810703
138positive regulation of immune response to tumor cell (GO:0002839)2.89810703
139regulation of immune response to tumor cell (GO:0002837)2.89810703
140male meiosis I (GO:0007141)2.88979548
141regulation of histone H3-K4 methylation (GO:0051569)2.88396253
142regulation of natural killer cell differentiation (GO:0032823)2.87619124
143protein targeting to membrane (GO:0006612)2.87408538
144deoxyribonucleotide catabolic process (GO:0009264)2.86732563
145deoxyribose phosphate catabolic process (GO:0046386)2.86633937
146synapsis (GO:0007129)2.85607874
147exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85506313
148RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.85480867
149negative regulation of mRNA processing (GO:0050686)2.84622169
150DNA double-strand break processing (GO:0000729)2.84329112
151centriole replication (GO:0007099)2.83995142
152genitalia morphogenesis (GO:0035112)2.82478524
153response to interleukin-15 (GO:0070672)2.82451454
154nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81718039
155L-serine metabolic process (GO:0006563)2.81102759
156response to interferon-beta (GO:0035456)2.81037990
157ubiquinone biosynthetic process (GO:0006744)2.80993476
158telomere maintenance via recombination (GO:0000722)2.79642830
159leukocyte homeostasis (GO:0001776)2.79359467
160NIK/NF-kappaB signaling (GO:0038061)2.78660511
161regulation of erythrocyte differentiation (GO:0045646)2.78654769
162defense response to protozoan (GO:0042832)2.78570770
163lymph node development (GO:0048535)2.78157998
164positive regulation of histone deacetylation (GO:0031065)2.77804400
165peptidyl-lysine trimethylation (GO:0018023)2.77186976
166positive regulation of T cell mediated cytotoxicity (GO:0001916)2.76664880
167tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76542125
168regulation of DNA endoreduplication (GO:0032875)2.76448007
169regulation of B cell differentiation (GO:0045577)2.75420514
170negative regulation of alpha-beta T cell activation (GO:0046636)2.73883490
171retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73100028
172positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.66798855
173valine metabolic process (GO:0006573)2.66759768
174negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66590038
175positive regulation of cellular amine metabolic process (GO:0033240)2.65377408
176alternative mRNA splicing, via spliceosome (GO:0000380)2.65295010
177regulation of lipid kinase activity (GO:0043550)2.63520853
178interkinetic nuclear migration (GO:0022027)2.63400603
179myeloid dendritic cell activation (GO:0001773)2.62313339
180histone deubiquitination (GO:0016578)2.60699716
181centriole assembly (GO:0098534)2.60697220
182iron ion import (GO:0097286)2.60596708
183mitochondrion distribution (GO:0048311)2.59687895
184B cell differentiation (GO:0030183)2.58471242
185erythrocyte differentiation (GO:0030218)2.58384076
186regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.57886963
187regulation of interleukin-12 biosynthetic process (GO:0045075)2.57133653
188myeloid cell development (GO:0061515)2.56688023
189positive regulation of gluconeogenesis (GO:0045722)2.55871968
190histone H3-K36 demethylation (GO:0070544)2.54288513
191regulation of histone H3-K27 methylation (GO:0061085)2.54212350
192negative regulation of B cell proliferation (GO:0030889)2.53966971
193positive regulation of DNA biosynthetic process (GO:2000573)2.53909198
194mRNA splice site selection (GO:0006376)2.53051142
195monoubiquitinated protein deubiquitination (GO:0035520)2.52730040
196histone H4-K16 acetylation (GO:0043984)2.52614536
197cellular response to interleukin-15 (GO:0071350)2.52480315
198negative regulation of metanephros development (GO:0072217)2.51896386
199response to protozoan (GO:0001562)2.51271340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.26205020
2GATA1_22025678_ChIP-Seq_K562_Human4.68416847
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.64344812
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.28233076
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.18758869
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.08074881
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.76486044
8SCL_19346495_ChIP-Seq_HPC-7_Human3.59303424
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.31263994
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23697362
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.21085607
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.21076478
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.19914552
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18989467
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.05903299
16CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00153480
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.87752962
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.85722763
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.85511522
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.77703383
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74232428
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61990027
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57872683
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55553832
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53382461
26RUNX_20019798_ChIP-Seq_JUKART_Human2.48660754
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43931833
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43067832
29AR_21909140_ChIP-Seq_LNCAP_Human2.42741965
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42088034
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34352598
32MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33729846
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28548750
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27386658
35MYC_22102868_ChIP-Seq_BL_Human2.22631345
36DCP1A_22483619_ChIP-Seq_HELA_Human2.21302669
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17468064
38TTF2_22483619_ChIP-Seq_HELA_Human2.16840483
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15246535
40E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11967262
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01913229
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00929801
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.96312669
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96103408
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95846521
46XRN2_22483619_ChIP-Seq_HELA_Human1.93043988
47GABP_19822575_ChIP-Seq_HepG2_Human1.90480335
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87902774
49ZNF274_21170338_ChIP-Seq_K562_Hela1.83307887
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79959809
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79886601
52MYC_18940864_ChIP-ChIP_HL60_Human1.76712469
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.74471304
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.73214002
55MYB_26560356_Chip-Seq_TH2_Human1.72695131
56* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71880377
57MYB_26560356_Chip-Seq_TH1_Human1.71832252
58SPI1_23547873_ChIP-Seq_NB4_Human1.68884608
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66526981
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65729439
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65595933
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.64772326
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62060321
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61592802
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.61585933
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61493347
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60823441
68CIITA_25753668_ChIP-Seq_RAJI_Human1.60238217
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58359137
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57412342
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.57156132
72TAF15_26573619_Chip-Seq_HEK293_Human1.55950177
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55885883
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.51191099
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48009123
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47151569
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47143508
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.46015388
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42861437
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.41589890
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41194026
82* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41169045
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.40798602
84TCF7_22412390_ChIP-Seq_EML_Mouse1.39780835
85VDR_21846776_ChIP-Seq_THP-1_Human1.38650671
86* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37637697
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37450156
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35565534
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31473604
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31316060
91EWS_26573619_Chip-Seq_HEK293_Human1.31110184
92ELK1_19687146_ChIP-ChIP_HELA_Human1.30989177
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30755726
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30725494
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29283649
96KDM5A_27292631_Chip-Seq_BREAST_Human1.29110386
97* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27689154
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26031414
99VDR_22108803_ChIP-Seq_LS180_Human1.26004314
100SPI1_23127762_ChIP-Seq_K562_Human1.22304123
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.20546406
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18015726
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17799984
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15462295
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15094613
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15008743
107MAF_26560356_Chip-Seq_TH1_Human1.14775724
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14530210
109UTX_26944678_Chip-Seq_JUKART_Human1.13969966
110BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13653135
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12852031
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11206143
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10401004
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10264361
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09548975
116SRF_21415370_ChIP-Seq_HL-1_Mouse1.08625722
117FUS_26573619_Chip-Seq_HEK293_Human1.07608141
118NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07083893
119FOXM1_23109430_ChIP-Seq_U2OS_Human1.06276783
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05357099
121PU_27001747_Chip-Seq_BMDM_Mouse1.05206628
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04828939
123ETS1_22383799_ChIP-Seq_G1ME_Mouse1.04184170
124FOXP3_21729870_ChIP-Seq_TREG_Human1.03740701
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02614698
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01650282
127GATA1_19941826_ChIP-Seq_K562_Human1.00381739
128GATA3_26560356_Chip-Seq_TH2_Human1.00266662
129GATA3_27048872_Chip-Seq_THYMUS_Human1.00069615
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99848947
131HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99038030
132TP53_22573176_ChIP-Seq_HFKS_Human0.97522239
133ELF5_23300383_ChIP-Seq_T47D_Human0.97246002
134IRF1_19129219_ChIP-ChIP_H3396_Human0.96576714
135GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96314898
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94265774
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94203108
138VDR_24763502_ChIP-Seq_THP-1_Human0.90665285
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.90535736
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.89469288
141VDR_23849224_ChIP-Seq_CD4+_Human0.89324576
142SALL4_22934838_ChIP-ChIP_CD34+_Human0.88114491
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.87874462
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87355643
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86787968
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86777126
147KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86290662
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85995125
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84656901
150MAF_26560356_Chip-Seq_TH2_Human0.83538740
151PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83300701
152HTT_18923047_ChIP-ChIP_STHdh_Human0.82608756
153E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81808397
154TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80790265
155BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79692298
156DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79056587
157CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78531276
158GATA3_21867929_ChIP-Seq_TH1_Mouse0.76774462
159CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76585971
160KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76295898
161IGF1R_20145208_ChIP-Seq_DFB_Human0.69962343
162IRF8_21731497_ChIP-ChIP_J774_Mouse0.67223433
163ELK1_22589737_ChIP-Seq_MCF10A_Human0.66755802
164FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65361354
165YY1_21170310_ChIP-Seq_MESCs_Mouse0.64093152
166GATA4_21415370_ChIP-Seq_HL-1_Mouse0.63216775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism5.96088664
2MP0004147_increased_porphyrin_level4.25423884
3MP0008058_abnormal_DNA_repair3.73845901
4MP0009379_abnormal_foot_pigmentation3.67631850
5MP0000569_abnormal_digit_pigmentation3.67631177
6MP0009697_abnormal_copulation3.33011677
7MP0002396_abnormal_hematopoietic_system2.89521276
8MP0002160_abnormal_reproductive_system2.72793980
9MP0002837_dystrophic_cardiac_calcinosis2.68821597
10MP0008995_early_reproductive_senescence2.60058951
11MP0005671_abnormal_response_to2.55650583
12MP0003656_abnormal_erythrocyte_physiolo2.55116557
13MP0003111_abnormal_nucleus_morphology2.54705521
14MP0003786_premature_aging2.51539908
15MP0004957_abnormal_blastocyst_morpholog2.50252572
16MP0005360_urolithiasis2.49424799
17MP0003943_abnormal_hepatobiliary_system2.45351924
18MP0005389_reproductive_system_phenotype2.42924738
19MP0002138_abnormal_hepatobiliary_system2.37433570
20MP0004808_abnormal_hematopoietic_stem2.36518364
21MP0003123_paternal_imprinting2.30240335
22MP0005174_abnormal_tail_pigmentation2.29276280
23MP0008877_abnormal_DNA_methylation2.28292018
24MP0003763_abnormal_thymus_physiology2.26387855
25MP0003806_abnormal_nucleotide_metabolis2.21527144
26MP0003693_abnormal_embryo_hatching2.16892069
27MP0002398_abnormal_bone_marrow2.15866499
28MP0005408_hypopigmentation2.13986540
29MP0008961_abnormal_basal_metabolism2.11032857
30MP0001800_abnormal_humoral_immune2.09127927
31MP0005365_abnormal_bile_salt2.08485734
32MP0001873_stomach_inflammation2.06868498
33MP0002139_abnormal_hepatobiliary_system2.02805699
34MP0001835_abnormal_antigen_presentation1.99180000
35MP0002166_altered_tumor_susceptibility1.94289554
36MP0000678_abnormal_parathyroid_gland1.93396074
37MP0000685_abnormal_immune_system1.91232435
38MP0008932_abnormal_embryonic_tissue1.88171324
39MP0003186_abnormal_redox_activity1.79871464
40MP0000716_abnormal_immune_system1.72816207
41MP0001529_abnormal_vocalization1.70647864
42MP0002210_abnormal_sex_determination1.70524467
43MP0002420_abnormal_adaptive_immunity1.67598309
44MP0003724_increased_susceptibility_to1.67457688
45MP0000689_abnormal_spleen_morphology1.66479356
46MP0005464_abnormal_platelet_physiology1.65378921
47MP0000703_abnormal_thymus_morphology1.64327630
48MP0002877_abnormal_melanocyte_morpholog1.63842307
49MP0002429_abnormal_blood_cell1.62056160
50MP0001790_abnormal_immune_system1.61258182
51MP0005387_immune_system_phenotype1.61258182
52MP0005000_abnormal_immune_tolerance1.61007264
53MP0001819_abnormal_immune_cell1.60872487
54MP0006072_abnormal_retinal_apoptosis1.58797717
55MP0002722_abnormal_immune_system1.58721354
56MP0002452_abnormal_antigen_presenting1.58552105
57MP0002723_abnormal_immune_serum1.56536972
58MP0003868_abnormal_feces_composition1.56446488
59MP0000049_abnormal_middle_ear1.55316649
60MP0000465_gastrointestinal_hemorrhage1.53901942
61MP0002006_tumorigenesis1.52529862
62MP0001919_abnormal_reproductive_system1.51096022
63MP0002419_abnormal_innate_immunity1.49852688
64MP0005332_abnormal_amino_acid1.49302271
65MP0003567_abnormal_fetal_cardiomyocyte1.49038310
66MP0005058_abnormal_lysosome_morphology1.48125850
67MP0001145_abnormal_male_reproductive1.45733612
68MP0005085_abnormal_gallbladder_physiolo1.45427093
69MP0004145_abnormal_muscle_electrophysio1.44960852
70MP0006054_spinal_hemorrhage1.42960517
71MP0001929_abnormal_gametogenesis1.42880574
72MP0010307_abnormal_tumor_latency1.42634373
73MP0008007_abnormal_cellular_replicative1.42222308
74MP0000490_abnormal_crypts_of1.42022710
75MP0003121_genomic_imprinting1.41541398
76MP0002234_abnormal_pharynx_morphology1.41471385
77MP0004215_abnormal_myocardial_fiber1.40506488
78MP0010094_abnormal_chromosome_stability1.39766311
79MP0003828_pulmonary_edema1.37321427
80MP0000653_abnormal_sex_gland1.35702086
81MP0005397_hematopoietic_system_phenotyp1.35655183
82MP0001545_abnormal_hematopoietic_system1.35655183
83MP0001986_abnormal_taste_sensitivity1.34323667
84MP0005025_abnormal_response_to1.33241585
85MP0003787_abnormal_imprinting1.30569027
86MP0004130_abnormal_muscle_cell1.25653274
87MP0005075_abnormal_melanosome_morpholog1.25160509
88MP0003436_decreased_susceptibility_to1.23475877
89MP0003122_maternal_imprinting1.17884724
90MP0002095_abnormal_skin_pigmentation1.17740683
91MP0002148_abnormal_hypersensitivity_rea1.13698516
92MP0008469_abnormal_protein_level1.13654279
93MP0001119_abnormal_female_reproductive1.11287806
94MP0000609_abnormal_liver_physiology1.10701578
95MP0003937_abnormal_limbs/digits/tail_de1.10181632
96MP0010155_abnormal_intestine_physiology1.09923090
97MP0005646_abnormal_pituitary_gland1.07521516
98MP0003718_maternal_effect1.06961164
99MP0009785_altered_susceptibility_to1.06114059
100MP0006035_abnormal_mitochondrial_morpho1.06048127
101MP0003698_abnormal_male_reproductive1.04372966
102MP0001661_extended_life_span1.03808005
103MP0002876_abnormal_thyroid_physiology1.03100627
104MP0000598_abnormal_liver_morphology1.02778190
105MP0006292_abnormal_olfactory_placode1.00958464
106MP0006036_abnormal_mitochondrial_physio1.00612939
107MP0003172_abnormal_lysosome_physiology0.98561815
108MP0000358_abnormal_cell_content/0.98372535
109MP0001845_abnormal_inflammatory_respons0.95882386
110MP0002405_respiratory_system_inflammati0.94863212
111MP0005410_abnormal_fertilization0.94529803
112MP0009333_abnormal_splenocyte_physiolog0.93627661
113MP0000639_abnormal_adrenal_gland0.91992686
114MP0010329_abnormal_lipoprotein_level0.91091184
115MP0001666_abnormal_nutrient_absorption0.90718052
116MP0000343_altered_response_to0.88847844
117MP0000749_muscle_degeneration0.88684781
118MP0002090_abnormal_vision0.87754501
119MP0002132_abnormal_respiratory_system0.87283055
120MP0005670_abnormal_white_adipose0.86665459
121MP0004019_abnormal_vitamin_homeostasis0.85956478
122MP0005584_abnormal_enzyme/coenzyme_acti0.85140553
123MP0000015_abnormal_ear_pigmentation0.84801583
124MP0009763_increased_sensitivity_to0.84426413
125MP0003252_abnormal_bile_duct0.80935268
126MP0005319_abnormal_enzyme/_coenzyme0.80255224
127MP0003300_gastrointestinal_ulcer0.78397302
128MP0005266_abnormal_metabolism0.78116924
129MP0003936_abnormal_reproductive_system0.77784351
130MP0002928_abnormal_bile_duct0.77146827
131MP0010030_abnormal_orbit_morphology0.76910839
132MP0005379_endocrine/exocrine_gland_phen0.75297436
133MP0005084_abnormal_gallbladder_morpholo0.74805152
134MP0009764_decreased_sensitivity_to0.73832006
135MP0000313_abnormal_cell_death0.73729526
136MP0001915_intracranial_hemorrhage0.71701258
137MP0001853_heart_inflammation0.71074903
138MP0008872_abnormal_physiological_respon0.70103869
139MP0009115_abnormal_fat_cell0.68697438
140MP0009765_abnormal_xenobiotic_induced0.68468605
141MP0009384_cardiac_valve_regurgitation0.68307209
142MP0002019_abnormal_tumor_incidence0.68231712
143MP0002822_catalepsy0.66668756
144MP0005310_abnormal_salivary_gland0.66401876
145MP0003866_abnormal_defecation0.66382855
146MP0001697_abnormal_embryo_size0.66162561
147MP0000613_abnormal_salivary_gland0.66057127
148MP0001764_abnormal_homeostasis0.66024076
149MP0003195_calcinosis0.65080096
150MP0003077_abnormal_cell_cycle0.65006027
151MP0002161_abnormal_fertility/fecundity0.64872194
152MP0000631_abnormal_neuroendocrine_gland0.63245924
153MP0005551_abnormal_eye_electrophysiolog0.62474701
154MP0004510_myositis0.61854099
155MP0008057_abnormal_DNA_replication0.61829608
156MP0003011_delayed_dark_adaptation0.61674220
157MP0001663_abnormal_digestive_system0.59577074
158MP0002938_white_spotting0.59473742
159MP0002163_abnormal_gland_morphology0.58833989
160MP0010630_abnormal_cardiac_muscle0.58822949
161MP0005220_abnormal_exocrine_pancreas0.58681495
162MP0002971_abnormal_brown_adipose0.58216113
163MP0002233_abnormal_nose_morphology0.57952369
164MP0004043_abnormal_pH_regulation0.57396296

Predicted human phenotypes

RankGene SetZ-score
1Abnormal delayed hypersensitivity skin test (HP:0002963)6.10256822
2Chronic mucocutaneous candidiasis (HP:0002728)5.31658379
3Recurrent cutaneous fungal infections (HP:0011370)5.31658379
4Increased hepatocellular lipid droplets (HP:0006565)5.23061352
5Acute necrotizing encephalopathy (HP:0006965)5.18826058
6Reticulocytopenia (HP:0001896)4.82100635
7Abnormality of T cell number (HP:0011839)4.77123776
8Mitochondrial inheritance (HP:0001427)4.69289091
9Lipid accumulation in hepatocytes (HP:0006561)4.68447269
10Abnormal mitochondria in muscle tissue (HP:0008316)4.65263287
11Abnormality of the heme biosynthetic pathway (HP:0010472)4.60458852
12Acute encephalopathy (HP:0006846)4.59335386
13T lymphocytopenia (HP:0005403)4.55306979
14Renal Fanconi syndrome (HP:0001994)4.55162591
15Recurrent viral infections (HP:0004429)4.52778670
16Cerebral edema (HP:0002181)4.49913470
17Progressive macrocephaly (HP:0004481)4.35339189
18Increased intramyocellular lipid droplets (HP:0012240)4.19552763
19Recurrent fungal infections (HP:0002841)4.08510212
20Absent rod-and cone-mediated responses on ERG (HP:0007688)4.07200275
21Increased CSF lactate (HP:0002490)4.06317099
22Hepatocellular necrosis (HP:0001404)4.00359336
23Hepatic necrosis (HP:0002605)3.86116758
24Agammaglobulinemia (HP:0004432)3.78143210
25Petechiae (HP:0000967)3.75763389
26Abnormality of the fingertips (HP:0001211)3.74089318
27Hypoplasia of the thymus (HP:0000778)3.69059072
28Exertional dyspnea (HP:0002875)3.57167184
29Abnormality of T cell physiology (HP:0011840)3.55032388
30Macrocytic anemia (HP:0001972)3.52226917
31Abnormality of cells of the erythroid lineage (HP:0012130)3.50438188
32Increased muscle lipid content (HP:0009058)3.38767287
33Limb hypertonia (HP:0002509)3.29526865
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.26229579
35Abnormality of renal resorption (HP:0011038)3.21372492
36Abnormality of T cells (HP:0002843)3.19145550
37Panhypogammaglobulinemia (HP:0003139)3.17137413
38Microvesicular hepatic steatosis (HP:0001414)3.14833285
39Stenosis of the external auditory canal (HP:0000402)3.11930541
40Recurrent skin infections (HP:0001581)3.11835945
41Respiratory difficulties (HP:0002880)3.11477464
42Asplenia (HP:0001746)3.05455998
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99959069
44Gingival bleeding (HP:0000225)2.98100740
45Mitral stenosis (HP:0001718)2.98026244
46Hypothermia (HP:0002045)2.94123808
47Hyperbilirubinemia (HP:0002904)2.93895847
48Autoimmune thrombocytopenia (HP:0001973)2.92718262
49Acanthocytosis (HP:0001927)2.91113819
50Degeneration of anterior horn cells (HP:0002398)2.89923685
51Abnormality of the anterior horn cell (HP:0006802)2.89923685
52Pallor (HP:0000980)2.89409953
53Hypochromic microcytic anemia (HP:0004840)2.89385836
54Abnormal rod and cone electroretinograms (HP:0008323)2.86389119
55Abnormality of the renal collecting system (HP:0004742)2.84625533
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83681646
57Aplasia/Hypoplasia of the spleen (HP:0010451)2.83000147
58Lactic acidosis (HP:0003128)2.81791563
59Gonadal dysgenesis (HP:0000133)2.77551108
60Prolonged bleeding time (HP:0003010)2.76798217
61Respiratory failure (HP:0002878)2.75295808
62Prolonged partial thromboplastin time (HP:0003645)2.75205251
63Albinism (HP:0001022)2.74980230
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73004186
65Fair hair (HP:0002286)2.69664712
66Glycosuria (HP:0003076)2.68031457
67Abnormality of urine glucose concentration (HP:0011016)2.68031457
68Chromsome breakage (HP:0040012)2.67016189
69Chronic diarrhea (HP:0002028)2.63071846
70Short middle phalanx of the 5th finger (HP:0004220)2.62143539
71Exercise intolerance (HP:0003546)2.60343583
72Abnormal number of erythroid precursors (HP:0012131)2.59251992
73Increased serum lactate (HP:0002151)2.57738594
74Chronic otitis media (HP:0000389)2.56967011
75Symptomatic seizures (HP:0011145)2.56109872
76Optic disc pallor (HP:0000543)2.55145282
77Hypoglycemic seizures (HP:0002173)2.54743752
78Birth length less than 3rd percentile (HP:0003561)2.53891678
79Microretrognathia (HP:0000308)2.52445665
80Intrahepatic cholestasis (HP:0001406)2.52093343
81Abnormality of the preputium (HP:0100587)2.51041408
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.48450027
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.46765080
84Absent thumb (HP:0009777)2.46154830
85Thyroid-stimulating hormone excess (HP:0002925)2.44634235
86Volvulus (HP:0002580)2.44218794
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43869829
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43869829
89Gastrointestinal stroma tumor (HP:0100723)2.43733420
90Median cleft lip (HP:0000161)2.43352430
91Hyperphosphaturia (HP:0003109)2.42750849
92Lymphopenia (HP:0001888)2.40849185
93Poikilocytosis (HP:0004447)2.40730947
94Protruding tongue (HP:0010808)2.38458975
95Pancreatic fibrosis (HP:0100732)2.36619504
96Abnormality of the phalanges of the 5th finger (HP:0004213)2.35821290
97Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.35459000
98IgG deficiency (HP:0004315)2.34189452
99Supernumerary spleens (HP:0009799)2.33246013
100Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.32577515
101Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.31854466
1023-Methylglutaconic aciduria (HP:0003535)2.29876661
103Epistaxis (HP:0000421)2.28742799
104Lower limb hyperreflexia (HP:0002395)2.28504017
105Colitis (HP:0002583)2.28454304
106Recurrent gram-negative bacterial infections (HP:0005420)2.27750451
107Abnormal platelet volume (HP:0011876)2.26336354
108Lethargy (HP:0001254)2.26003909
109Aortic regurgitation (HP:0001659)2.25661505
110Increased mean platelet volume (HP:0011877)2.25585765
111Acute myeloid leukemia (HP:0004808)2.21555674
112Inflammation of the large intestine (HP:0002037)2.21133471
113Abnormal urine phosphate concentration (HP:0012599)2.18782966
114Short 1st metacarpal (HP:0010034)2.17598452
115Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.17598452
116Leukodystrophy (HP:0002415)2.17446144
117Purpura (HP:0000979)2.17257945
118Depressed nasal tip (HP:0000437)2.17032984
119Abnormality of chromosome stability (HP:0003220)2.17006519
120Hypochromic anemia (HP:0001931)2.16249876
121Polydipsia (HP:0001959)2.15688512
122Abnormal drinking behavior (HP:0030082)2.15688512
123Verrucae (HP:0200043)2.15422176
124Papilloma (HP:0012740)2.15422176
125Long eyelashes (HP:0000527)2.15011194
126Male pseudohermaphroditism (HP:0000037)2.13003700
127Macroorchidism (HP:0000053)2.12408189
128Recurrent bronchitis (HP:0002837)2.11787571
129Severe combined immunodeficiency (HP:0004430)2.11777903
130Meckel diverticulum (HP:0002245)2.10270107
131Hyperglycinemia (HP:0002154)2.09809802
132Testicular neoplasm (HP:0010788)2.09029674
133Female pseudohermaphroditism (HP:0010458)2.08609988
134Abnormal lung lobation (HP:0002101)2.07874190
135Reduced antithrombin III activity (HP:0001976)2.06747138
136Neutropenia (HP:0001875)2.05263227
137Inappropriate behavior (HP:0000719)2.01521346
138Hepatitis (HP:0012115)2.01342022
139Dyschromatopsia (HP:0007641)2.00271343
140Abnormality of the ileum (HP:0001549)1.99861167
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99756370
142Hypoglycemic coma (HP:0001325)1.99553779
143Aplastic anemia (HP:0001915)1.98747017
144Abnormality of cochlea (HP:0000375)1.98124072
145Recurrent bacterial skin infections (HP:0005406)1.97685036
146Bile duct proliferation (HP:0001408)1.97531154
147Abnormal biliary tract physiology (HP:0012439)1.97531154
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97296655
149True hermaphroditism (HP:0010459)1.95737145
150Cellulitis (HP:0100658)1.94937564
151Abnormality of eosinophils (HP:0001879)1.93947618
152Heterotopia (HP:0002282)1.93572723
153Duodenal stenosis (HP:0100867)1.93470227
154Small intestinal stenosis (HP:0012848)1.93470227
155Thyroiditis (HP:0100646)1.93019875
156Pancreatic islet-cell hyperplasia (HP:0004510)1.92563365
157Generalized hypopigmentation of hair (HP:0011358)1.92281435
158Abnormal platelet function (HP:0011869)1.90484103
159Impaired platelet aggregation (HP:0003540)1.90484103
160Abnormality of the 1st metacarpal (HP:0010009)1.89089110
161Pancytopenia (HP:0001876)1.88726097
162Acute lymphatic leukemia (HP:0006721)1.87006320
163Gastrointestinal inflammation (HP:0004386)1.86412097
164Deep venous thrombosis (HP:0002625)1.86090863
165Conjugated hyperbilirubinemia (HP:0002908)1.85653319
166Chronic sinusitis (HP:0011109)1.84618722
167Constricted visual fields (HP:0001133)1.83738543
16811 pairs of ribs (HP:0000878)1.83696311
169Triphalangeal thumb (HP:0001199)1.83000461
170Recurrent abscess formation (HP:0002722)1.82268872
171CNS demyelination (HP:0007305)1.80022775
172Pancreatic cysts (HP:0001737)1.78096610
173Severe visual impairment (HP:0001141)1.77544673
174Anomalous pulmonary venous return (HP:0010772)1.77360609
175Menorrhagia (HP:0000132)1.75499828
176Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74976666
177Osteomyelitis (HP:0002754)1.73578890
178Recurrent sinusitis (HP:0011108)1.72975308
179Meningitis (HP:0001287)1.72374501
180Long clavicles (HP:0000890)1.72255731
181Combined immunodeficiency (HP:0005387)1.71603345
182X-linked dominant inheritance (HP:0001423)1.71185548
183Increased serum pyruvate (HP:0003542)1.70915155
184Elevated hepatic transaminases (HP:0002910)1.70516969
185Generalized aminoaciduria (HP:0002909)1.70510563
186Atrophy/Degeneration involving motor neurons (HP:0007373)1.70059037
187Abnormality of the duodenum (HP:0002246)1.69468413
188Molar tooth sign on MRI (HP:0002419)1.67988063
189Abnormality of midbrain morphology (HP:0002418)1.67988063
190Viral hepatitis (HP:0006562)1.67174291
191Cellular immunodeficiency (HP:0005374)1.67110210
192Abnormality of iron homeostasis (HP:0011031)1.66576674
193Ectopic kidney (HP:0000086)1.65862805
194Granulocytopenia (HP:0001913)1.64511987
195Mediastinal lymphadenopathy (HP:0100721)1.64430886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.64805088
2TIE16.16098479
3TNIK5.24550285
4NME24.15844655
5CCNB13.56332285
6TEC3.07473340
7INSRR3.03212814
8KIT3.00636801
9STK163.00524252
10CDK192.52972446
11NEK12.47998941
12EIF2AK12.43870539
13SIK32.42445297
14PDK22.04884981
15PLK41.97837503
16TXK1.97028627
17SIK21.94055552
18MAP4K11.89669593
19TYK21.79722630
20MAP3K101.73822793
21IRAK41.55446929
22CLK11.52814755
23MAP3K121.46104337
24NEK91.39861094
25PLK11.39182906
26SIK11.37575828
27BMPR21.37101049
28NLK1.36551369
29PIK3CA1.36080964
30DYRK31.34590573
31ILK1.30703826
32MKNK11.26604207
33BRAF1.25232528
34CAMK1G1.23955990
35MAP3K141.23547386
36LRRK21.19891639
37RPS6KA41.18145960
38YES11.17961225
39JAK11.17905115
40STK101.14583725
41ACVR1B1.12508082
42MST41.12152558
43MAP2K71.11720399
44MYLK1.09559812
45TAOK31.08168620
46ABL21.07297401
47NUAK11.05511086
48CSK1.02716328
49VRK11.01506740
50AURKB1.00830788
51FES0.99512863
52CDK40.98647520
53MAP3K130.98534210
54PKN20.97954158
55AURKA0.96558021
56WNK40.96438624
57PLK30.96350213
58OXSR10.95949388
59STK40.94817124
60ZAK0.93864625
61ITK0.93833267
62CHEK10.92765657
63EIF2AK20.92694896
64CAMK1D0.90813346
65CDK80.90778684
66SYK0.90174813
67TTK0.89694667
68PASK0.88339266
69CHEK20.88262900
70JAK30.88055225
71TLK10.87505164
72CDC42BPA0.84740091
73SRPK10.84321750
74EEF2K0.84050569
75IKBKE0.83234145
76GRK60.81553895
77PIM10.79123133
78CDK120.77230288
79STK30.77189186
80MAPK150.76883243
81TGFBR20.76685311
82BUB10.76504647
83MATK0.75235009
84STK390.74958266
85PIK3CG0.74825814
86GRK70.74020339
87CHUK0.73278359
88ATR0.72173657
89VRK20.71718852
90FRK0.71033294
91LCK0.70208205
92BTK0.68893520
93IKBKB0.68691908
94ARAF0.68630370
95FLT30.68409408
96CSF1R0.67949704
97RPS6KB20.66149000
98OBSCN0.65625413
99CAMK10.65393807
100MAP3K70.65359985
101GRK10.65227399
102NEK20.65045393
103LYN0.64943762
104ERBB30.64349309
105CSNK2A20.63993981
106DAPK30.63593431
107ERN10.63461540
108CSNK2A10.63385024
109CDC70.63181254
110BMPR1B0.62073039
111RPS6KA60.59933027
112JAK20.59086264
113PTK60.58699330
114RPS6KL10.58233441
115RPS6KC10.58233441
116KDR0.58175021
117DYRK20.57988460
118BCR0.56971061
119MKNK20.56941322
120PAK30.56560581
121BRSK10.56315928
122MUSK0.54195122
123RIPK40.53751355
124ATM0.53252981
125PIM20.52208349
126CDK60.52120512
127MAP2K40.52085591
128PRKCI0.51835934
129TNK20.51326441
130MAPK110.50906328
131EIF2AK30.50836311
132CDK30.49945546
133PRKAA20.48158813
134MARK20.46820607
135PAK20.46523066
136MAP2K30.46213629
137FGFR40.45825997
138BRSK20.45605664
139SGK20.44703466
140TRPM70.43882092
141MAPK120.43315040
142CDK90.43311453
143ALK0.42576518
144ADRBK20.42008313
145IRAK30.41960856
146WEE10.40236072
147MAPK40.40055783
148ZAP700.39735123
149CDK70.39605157
150MARK30.38762012
151STK240.37364262
152NME10.37155376
153PDGFRB0.37022300
154HCK0.36718053
155PRKCQ0.36547898
156MOS0.36047819
157RPS6KA10.32795523
158SCYL20.32719623
159PRKCE0.32598183
160PAK10.32594209
161PBK0.32281282
162CDK20.31598624
163CDK10.28821540
164ABL10.28479683
165AKT20.27666149
166PRKCD0.26528297
167TAF10.26230928
168RPS6KA50.26147433

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.14610344
2Oxidative phosphorylation_Homo sapiens_hsa001903.59365005
3Primary immunodeficiency_Homo sapiens_hsa053403.43901062
4Sulfur relay system_Homo sapiens_hsa041223.31570725
5Parkinsons disease_Homo sapiens_hsa050123.10891570
6Measles_Homo sapiens_hsa051622.60558452
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47248266
8Hematopoietic cell lineage_Homo sapiens_hsa046402.43029647
9Fanconi anemia pathway_Homo sapiens_hsa034602.39412125
10B cell receptor signaling pathway_Homo sapiens_hsa046622.34225138
11Non-homologous end-joining_Homo sapiens_hsa034502.32020012
12Herpes simplex infection_Homo sapiens_hsa051682.19854918
13Huntingtons disease_Homo sapiens_hsa050162.17362987
14Proteasome_Homo sapiens_hsa030502.13891839
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.07270673
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05153781
17Acute myeloid leukemia_Homo sapiens_hsa052212.01785636
18Nucleotide excision repair_Homo sapiens_hsa034201.99708383
19ABC transporters_Homo sapiens_hsa020101.96968544
20Lysine degradation_Homo sapiens_hsa003101.95766106
21Alzheimers disease_Homo sapiens_hsa050101.94968301
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93816806
23One carbon pool by folate_Homo sapiens_hsa006701.93348635
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88309189
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.86504040
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83770158
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80985856
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.80890841
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71945521
30T cell receptor signaling pathway_Homo sapiens_hsa046601.68123126
31Asthma_Homo sapiens_hsa053101.66816576
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.59943043
33Propanoate metabolism_Homo sapiens_hsa006401.49062930
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48442588
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.44366335
36Hepatitis B_Homo sapiens_hsa051611.42530727
37RNA transport_Homo sapiens_hsa030131.41997014
38RNA degradation_Homo sapiens_hsa030181.41537018
39Cardiac muscle contraction_Homo sapiens_hsa042601.40699603
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37874341
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35984601
42Allograft rejection_Homo sapiens_hsa053301.35961787
43Leishmaniasis_Homo sapiens_hsa051401.34778253
44Influenza A_Homo sapiens_hsa051641.33248755
45Protein export_Homo sapiens_hsa030601.30157305
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.28672643
47DNA replication_Homo sapiens_hsa030301.27767611
48Thyroid cancer_Homo sapiens_hsa052161.27213132
49Glutathione metabolism_Homo sapiens_hsa004801.24319507
50Chronic myeloid leukemia_Homo sapiens_hsa052201.23242782
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23178305
52Autoimmune thyroid disease_Homo sapiens_hsa053201.23096859
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20364077
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17480665
55Fatty acid degradation_Homo sapiens_hsa000711.14847007
56Antigen processing and presentation_Homo sapiens_hsa046121.07001505
57Tryptophan metabolism_Homo sapiens_hsa003801.05853589
58Platelet activation_Homo sapiens_hsa046111.04941623
59Systemic lupus erythematosus_Homo sapiens_hsa053221.02900842
60Peroxisome_Homo sapiens_hsa041460.99623694
61Viral carcinogenesis_Homo sapiens_hsa052030.98579765
62Purine metabolism_Homo sapiens_hsa002300.98509541
63Hepatitis C_Homo sapiens_hsa051600.98461534
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97140304
65Osteoclast differentiation_Homo sapiens_hsa043800.95427662
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.94729366
67Prolactin signaling pathway_Homo sapiens_hsa049170.94249949
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93952414
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93177296
70Basal transcription factors_Homo sapiens_hsa030220.92553952
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91429216
72Small cell lung cancer_Homo sapiens_hsa052220.91327941
73Complement and coagulation cascades_Homo sapiens_hsa046100.89858298
74Type I diabetes mellitus_Homo sapiens_hsa049400.88319237
75Non-small cell lung cancer_Homo sapiens_hsa052230.86420082
76Toxoplasmosis_Homo sapiens_hsa051450.86286551
77Rheumatoid arthritis_Homo sapiens_hsa053230.84711786
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82379133
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82235912
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80910348
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80521010
82Base excision repair_Homo sapiens_hsa034100.80339056
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78349325
84Chemokine signaling pathway_Homo sapiens_hsa040620.74324964
85Homologous recombination_Homo sapiens_hsa034400.74239597
86Fatty acid elongation_Homo sapiens_hsa000620.73948115
87Graft-versus-host disease_Homo sapiens_hsa053320.72656141
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72168276
89beta-Alanine metabolism_Homo sapiens_hsa004100.71678653
90Insulin resistance_Homo sapiens_hsa049310.70715541
91Starch and sucrose metabolism_Homo sapiens_hsa005000.70497270
92Pyruvate metabolism_Homo sapiens_hsa006200.70270666
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69876211
94Chemical carcinogenesis_Homo sapiens_hsa052040.67048549
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67022015
96Metabolic pathways_Homo sapiens_hsa011000.66980036
97RNA polymerase_Homo sapiens_hsa030200.66335119
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66326786
99PPAR signaling pathway_Homo sapiens_hsa033200.65594407
100p53 signaling pathway_Homo sapiens_hsa041150.65039594
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64703940
102Pancreatic cancer_Homo sapiens_hsa052120.63936808
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.63682921
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63341942
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62802145
106Spliceosome_Homo sapiens_hsa030400.61485278
107Epstein-Barr virus infection_Homo sapiens_hsa051690.60579133
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60247261
109Staphylococcus aureus infection_Homo sapiens_hsa051500.59127354
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58726589
111Cell cycle_Homo sapiens_hsa041100.58681518
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58585531
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58368926
114Pyrimidine metabolism_Homo sapiens_hsa002400.57580212
115African trypanosomiasis_Homo sapiens_hsa051430.57404803
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56828498
117Tuberculosis_Homo sapiens_hsa051520.56023918
118Sulfur metabolism_Homo sapiens_hsa009200.54672693
119Apoptosis_Homo sapiens_hsa042100.54246744
120Folate biosynthesis_Homo sapiens_hsa007900.54115106
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53381137
122Nitrogen metabolism_Homo sapiens_hsa009100.53331818
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50766008
124Fatty acid metabolism_Homo sapiens_hsa012120.50181366
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48414470
126FoxO signaling pathway_Homo sapiens_hsa040680.46938224
127ErbB signaling pathway_Homo sapiens_hsa040120.45749223
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44578728
129N-Glycan biosynthesis_Homo sapiens_hsa005100.43731234
130Selenocompound metabolism_Homo sapiens_hsa004500.43217820
131Prostate cancer_Homo sapiens_hsa052150.41749794
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41232771
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.40609118
134Retinol metabolism_Homo sapiens_hsa008300.40607594
135Mismatch repair_Homo sapiens_hsa034300.39983360
136Legionellosis_Homo sapiens_hsa051340.39437570
137Pentose phosphate pathway_Homo sapiens_hsa000300.39402491
138Galactose metabolism_Homo sapiens_hsa000520.39282149
139mRNA surveillance pathway_Homo sapiens_hsa030150.38410444
140Histidine metabolism_Homo sapiens_hsa003400.37955198
141Endometrial cancer_Homo sapiens_hsa052130.37763700
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37439828
143Carbon metabolism_Homo sapiens_hsa012000.37362478
144Butanoate metabolism_Homo sapiens_hsa006500.37287700
145MicroRNAs in cancer_Homo sapiens_hsa052060.36214256
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.33604005
147Caffeine metabolism_Homo sapiens_hsa002320.33044264
148Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23503802
149Steroid biosynthesis_Homo sapiens_hsa001000.21902956
150Oocyte meiosis_Homo sapiens_hsa041140.20533795
151Arginine and proline metabolism_Homo sapiens_hsa003300.20323659
152Olfactory transduction_Homo sapiens_hsa047400.19192138

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