MTCYBP18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.96340618
2fucose catabolic process (GO:0019317)4.14768438
3L-fucose metabolic process (GO:0042354)4.14768438
4L-fucose catabolic process (GO:0042355)4.14768438
5regulation of female receptivity (GO:0045924)4.03274520
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.91593345
7sleep (GO:0030431)3.82257236
8platelet dense granule organization (GO:0060155)3.80502978
9kynurenine metabolic process (GO:0070189)3.75307020
10positive regulation of defense response to virus by host (GO:0002230)3.72180402
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.72163635
12preassembly of GPI anchor in ER membrane (GO:0016254)3.71360215
13regulation of memory T cell differentiation (GO:0043380)3.67117984
14tryptophan catabolic process (GO:0006569)3.60415073
15indole-containing compound catabolic process (GO:0042436)3.60415073
16indolalkylamine catabolic process (GO:0046218)3.60415073
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58199030
18female mating behavior (GO:0060180)3.42635599
19cytidine catabolic process (GO:0006216)3.42509575
20cytidine deamination (GO:0009972)3.42509575
21cytidine metabolic process (GO:0046087)3.42509575
22positive regulation of T cell differentiation in thymus (GO:0033089)3.37119349
23tryptophan metabolic process (GO:0006568)3.36166249
24fat-soluble vitamin catabolic process (GO:0042363)3.35009695
25vitamin catabolic process (GO:0009111)3.35009695
26indolalkylamine metabolic process (GO:0006586)3.32297628
27detection of light stimulus involved in visual perception (GO:0050908)3.28672731
28detection of light stimulus involved in sensory perception (GO:0050962)3.28672731
29regulation of germinal center formation (GO:0002634)3.28457661
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.25931494
31endoderm formation (GO:0001706)3.25744975
32mature B cell differentiation involved in immune response (GO:0002313)3.22724824
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18462760
34ATP synthesis coupled proton transport (GO:0015986)3.18462760
35positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.18310502
36regulation of regulatory T cell differentiation (GO:0045589)3.11441439
37mitotic cell cycle arrest (GO:0071850)3.11131407
38piRNA metabolic process (GO:0034587)3.10017350
39positive regulation of T-helper 1 type immune response (GO:0002827)3.06584495
40negative regulation of mast cell activation (GO:0033004)3.05240878
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.00055347
42positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.98454377
43cellular response to interleukin-15 (GO:0071350)2.94538167
44negative T cell selection (GO:0043383)2.92693198
45rRNA catabolic process (GO:0016075)2.92487155
46positive regulation of alpha-beta T cell proliferation (GO:0046641)2.91612559
47positive regulation of fatty acid transport (GO:2000193)2.91155156
48regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.89650866
49positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87896668
50mannosylation (GO:0097502)2.87888608
51regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.85520707
52regulation of T cell mediated cytotoxicity (GO:0001914)2.81972382
53regulation of isotype switching to IgG isotypes (GO:0048302)2.81638495
54pyrimidine ribonucleoside catabolic process (GO:0046133)2.81604277
55mast cell activation (GO:0045576)2.81189850
56respiratory chain complex IV assembly (GO:0008535)2.78020989
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.74782651
58negative thymic T cell selection (GO:0045060)2.74365549
59behavioral response to nicotine (GO:0035095)2.71645505
60regulation of T-helper 1 type immune response (GO:0002825)2.71399233
61protein polyglutamylation (GO:0018095)2.70363536
62regulation of immunoglobulin secretion (GO:0051023)2.70179484
63mature B cell differentiation (GO:0002335)2.69534865
64positive regulation of glomerulus development (GO:0090193)2.67945673
65negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.64600597
66DNA methylation involved in gamete generation (GO:0043046)2.63456279
67regulation of defense response to virus by host (GO:0050691)2.60912888
68regulation of T cell receptor signaling pathway (GO:0050856)2.60485817
69positive regulation of calcium-mediated signaling (GO:0050850)2.59483346
70positive regulation of icosanoid secretion (GO:0032305)2.58841013
71cellular response to ATP (GO:0071318)2.58519862
72negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.58457168
73water-soluble vitamin biosynthetic process (GO:0042364)2.58127974
74positive regulation of interleukin-17 production (GO:0032740)2.53460652
75positive regulation of prostaglandin secretion (GO:0032308)2.53110145
76positive regulation of activated T cell proliferation (GO:0042104)2.52012330
77positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.51750919
78somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.51272019
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.51272019
80isotype switching (GO:0045190)2.51272019
81interferon-gamma production (GO:0032609)2.50674917
82B cell activation involved in immune response (GO:0002312)2.50054514
83regulation of mesoderm development (GO:2000380)2.48919522
84cytochrome complex assembly (GO:0017004)2.48328194
85positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.48323311
86protein K6-linked ubiquitination (GO:0085020)2.48029791
87negative regulation of telomere maintenance (GO:0032205)2.47490045
88regulation of alpha-beta T cell proliferation (GO:0046640)2.47418235
89positive regulation of cAMP-mediated signaling (GO:0043950)2.43531865
90regulation of leukocyte mediated cytotoxicity (GO:0001910)2.43096522
91electron transport chain (GO:0022900)2.40300788
92multicellular organism reproduction (GO:0032504)2.39218394
93positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.38074212
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.37863388
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37791133
96adenosine metabolic process (GO:0046085)2.37651474
97benzene-containing compound metabolic process (GO:0042537)2.37613725
98dopamine transport (GO:0015872)2.37460484
99positive regulation of antigen processing and presentation (GO:0002579)2.37252742
100drug catabolic process (GO:0042737)2.37224833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.14484341
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.26918083
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.13666441
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.96634255
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77863926
6VDR_22108803_ChIP-Seq_LS180_Human2.70587542
7ZNF274_21170338_ChIP-Seq_K562_Hela2.65942542
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60813952
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.43787369
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.09023527
11PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94033930
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93569581
13GATA3_26560356_Chip-Seq_TH2_Human1.92580979
14NOTCH1_21737748_ChIP-Seq_TLL_Human1.88725323
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79785550
16GBX2_23144817_ChIP-Seq_PC3_Human1.76907956
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73619135
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71444224
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69177656
20RUNX_20019798_ChIP-Seq_JUKART_Human1.67857141
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67818733
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67293703
23ER_23166858_ChIP-Seq_MCF-7_Human1.64714834
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63705351
25TP53_22573176_ChIP-Seq_HFKS_Human1.63320390
26IRF1_19129219_ChIP-ChIP_H3396_Human1.59253993
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56695666
28EWS_26573619_Chip-Seq_HEK293_Human1.55444745
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50902963
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.48116467
31FOXA1_25329375_ChIP-Seq_VCAP_Human1.46699017
32FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46699017
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.46545177
34AR_20517297_ChIP-Seq_VCAP_Human1.45863076
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45168168
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.45109751
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44056121
38P300_19829295_ChIP-Seq_ESCs_Human1.43303559
39VDR_23849224_ChIP-Seq_CD4+_Human1.42613312
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42112296
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41549338
42NANOG_19829295_ChIP-Seq_ESCs_Human1.40676838
43SOX2_19829295_ChIP-Seq_ESCs_Human1.40676838
44IGF1R_20145208_ChIP-Seq_DFB_Human1.39863629
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39370049
46BCAT_22108803_ChIP-Seq_LS180_Human1.38395251
47CBP_20019798_ChIP-Seq_JUKART_Human1.37860813
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37860813
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.37372029
50MYB_26560356_Chip-Seq_TH2_Human1.37197759
51FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35253120
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.34251243
53NCOR_22424771_ChIP-Seq_293T_Human1.32743217
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31957035
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31660878
56MYC_18940864_ChIP-ChIP_HL60_Human1.31351572
57FUS_26573619_Chip-Seq_HEK293_Human1.31189253
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31054666
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.30985184
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30541664
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27742600
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27358273
63TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23420108
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.22255171
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22154255
66HOXB7_26014856_ChIP-Seq_BT474_Human1.20323288
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.17265525
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.17012654
69TAF15_26573619_Chip-Seq_HEK293_Human1.16408507
70TAF2_19829295_ChIP-Seq_ESCs_Human1.16330271
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.16252760
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15698394
73GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.14713301
74GATA3_27048872_Chip-Seq_THYMUS_Human1.13738039
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13631524
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12990850
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11543371
78TCF4_23295773_ChIP-Seq_U87_Human1.11531252
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09829539
80TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09640160
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.09237513
82FOXP3_21729870_ChIP-Seq_TREG_Human1.07272002
83P53_21459846_ChIP-Seq_SAOS-2_Human1.06187236
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05564573
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04529966
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04224920
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03346923
88ELK1_19687146_ChIP-ChIP_HELA_Human1.02953275
89ETV1_20927104_ChIP-Seq_GIST48_Human1.02805667
90MYC_19829295_ChIP-Seq_ESCs_Human1.02260038
91STAT3_23295773_ChIP-Seq_U87_Human1.00698019
92ERG_20517297_ChIP-Seq_VCAP_Human1.00616786
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99168922
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98931425
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98578865
96AR_25329375_ChIP-Seq_VCAP_Human0.97898797
97TCF4_22108803_ChIP-Seq_LS180_Human0.97756894
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97734666
99CDX2_22108803_ChIP-Seq_LS180_Human0.97734297
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96655594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.44305546
2MP0005671_abnormal_response_to3.17198474
3MP0002736_abnormal_nociception_after3.07862594
4MP0001968_abnormal_touch/_nociception2.99881951
5MP0003724_increased_susceptibility_to2.89159657
6MP0003195_calcinosis2.72395578
7MP0001835_abnormal_antigen_presentation2.63655393
8MP0005646_abnormal_pituitary_gland2.57388679
9MP0008877_abnormal_DNA_methylation2.33340229
10MP0002138_abnormal_hepatobiliary_system2.28044539
11MP0002148_abnormal_hypersensitivity_rea2.19636928
12MP0006072_abnormal_retinal_apoptosis2.13987528
13MP0008872_abnormal_physiological_respon2.12857209
14MP0002102_abnormal_ear_morphology2.02421109
15MP0002653_abnormal_ependyma_morphology1.94537469
16MP0005000_abnormal_immune_tolerance1.92784186
17MP0002876_abnormal_thyroid_physiology1.90266463
18MP0003646_muscle_fatigue1.87127954
19MP0001800_abnormal_humoral_immune1.86347967
20MP0008875_abnormal_xenobiotic_pharmacok1.80797056
21MP0005645_abnormal_hypothalamus_physiol1.79370169
22MP0009785_altered_susceptibility_to1.76734921
23MP0002837_dystrophic_cardiac_calcinosis1.71567989
24MP0001501_abnormal_sleep_pattern1.68232424
25MP0004147_increased_porphyrin_level1.67032358
26MP0004885_abnormal_endolymph1.66229334
27MP0000685_abnormal_immune_system1.60475741
28MP0001986_abnormal_taste_sensitivity1.59842256
29MP0002723_abnormal_immune_serum1.52242847
30MP0009333_abnormal_splenocyte_physiolog1.51596389
31MP0004043_abnormal_pH_regulation1.48338033
32MP0003866_abnormal_defecation1.47938312
33MP0003763_abnormal_thymus_physiology1.45330563
34MP0005551_abnormal_eye_electrophysiolog1.43671642
35MP0009697_abnormal_copulation1.43025714
36MP0002166_altered_tumor_susceptibility1.40573185
37MP0002452_abnormal_antigen_presenting1.35969967
38MP0005389_reproductive_system_phenotype1.35958965
39MP0005387_immune_system_phenotype1.34311196
40MP0001790_abnormal_immune_system1.34311196
41MP0009764_decreased_sensitivity_to1.32186037
42MP0001819_abnormal_immune_cell1.29170722
43MP0009840_abnormal_foam_cell1.28731611
44MP0002420_abnormal_adaptive_immunity1.27379901
45MP0005253_abnormal_eye_physiology1.24925907
46MP0001919_abnormal_reproductive_system1.24500665
47MP0003011_delayed_dark_adaptation1.24423651
48MP0005167_abnormal_blood-brain_barrier1.21619236
49MP0001765_abnormal_ion_homeostasis1.20177105
50MP0001873_stomach_inflammation1.18066423
51MP0010155_abnormal_intestine_physiology1.17224729
52MP0010329_abnormal_lipoprotein_level1.15763367
53MP0001764_abnormal_homeostasis1.15040113
54MP0003252_abnormal_bile_duct1.14312577
55MP0005075_abnormal_melanosome_morpholog1.10934314
56MP0002928_abnormal_bile_duct1.09219263
57MP0001845_abnormal_inflammatory_respons1.08346500
58MP0005332_abnormal_amino_acid1.08210318
59MP0003806_abnormal_nucleotide_metabolis1.06850673
60MP0002277_abnormal_respiratory_mucosa1.05331486
61MP0003436_decreased_susceptibility_to1.05274633
62MP0000230_abnormal_systemic_arterial1.05027003
63MP0006276_abnormal_autonomic_nervous1.04214531
64MP0002272_abnormal_nervous_system1.04024747
65MP0002006_tumorigenesis1.02520058
66MP0004145_abnormal_muscle_electrophysio1.02406997
67MP0005025_abnormal_response_to1.02344074
68MP0006036_abnormal_mitochondrial_physio1.00810790
69MP0000678_abnormal_parathyroid_gland0.98520543
70MP0004215_abnormal_myocardial_fiber0.98240918
71MP0008775_abnormal_heart_ventricle0.97641741
72MP0001533_abnormal_skeleton_physiology0.97614312
73MP0005085_abnormal_gallbladder_physiolo0.95825230
74MP0003718_maternal_effect0.95721152
75MP0000013_abnormal_adipose_tissue0.95534914
76MP0005636_abnormal_mineral_homeostasis0.94918149
77MP0010386_abnormal_urinary_bladder0.92913634
78MP0000427_abnormal_hair_cycle0.88942316
79MP0000372_irregular_coat_pigmentation0.86233576
80MP0001661_extended_life_span0.84287867
81MP0002933_joint_inflammation0.84196930
82MP0000465_gastrointestinal_hemorrhage0.84090681
83MP0000716_abnormal_immune_system0.83534663
84MP0000689_abnormal_spleen_morphology0.83376735
85MP0002693_abnormal_pancreas_physiology0.82596794
86MP0002398_abnormal_bone_marrow0.82554060
87MP0009643_abnormal_urine_homeostasis0.81918902
88MP0002419_abnormal_innate_immunity0.81454043
89MP0006292_abnormal_olfactory_placode0.81265272
90MP0002160_abnormal_reproductive_system0.81030378
91MP0003950_abnormal_plasma_membrane0.80379520
92MP0005410_abnormal_fertilization0.79024124
93MP0002405_respiratory_system_inflammati0.78531038
94MP0004947_skin_inflammation0.78216021
95MP0009745_abnormal_behavioral_response0.77672071
96MP0003283_abnormal_digestive_organ0.77629552
97MP0008469_abnormal_protein_level0.77463991
98MP0005084_abnormal_gallbladder_morpholo0.75966837
99MP0001970_abnormal_pain_threshold0.74836179
100MP0005174_abnormal_tail_pigmentation0.71136321

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.15266777
2Abnormality of the renal cortex (HP:0011035)3.36729942
3Congenital stationary night blindness (HP:0007642)3.31513804
4Renal cortical cysts (HP:0000803)3.30774223
5Abolished electroretinogram (ERG) (HP:0000550)3.28033056
6Stomatitis (HP:0010280)3.26150806
7Congenital, generalized hypertrichosis (HP:0004540)3.24321264
8Pancreatic cysts (HP:0001737)3.13058150
9Absent/shortened dynein arms (HP:0200106)3.00013229
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.00013229
11Decreased central vision (HP:0007663)2.98950653
12Decreased electroretinogram (ERG) amplitude (HP:0000654)2.97783492
13Elevated erythrocyte sedimentation rate (HP:0003565)2.94324942
14Stomach cancer (HP:0012126)2.92990042
15Severe combined immunodeficiency (HP:0004430)2.85595688
16Attenuation of retinal blood vessels (HP:0007843)2.81024945
17Thyroiditis (HP:0100646)2.76966300
18Type II lissencephaly (HP:0007260)2.75549095
19Abnormality of the costochondral junction (HP:0000919)2.73434305
20Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72153135
21Keratoconjunctivitis (HP:0001096)2.70407678
22Abnormality of B cell number (HP:0010975)2.67122760
23Constricted visual fields (HP:0001133)2.62577806
24Keratoconjunctivitis sicca (HP:0001097)2.61815863
25Generalized aminoaciduria (HP:0002909)2.60832470
26Polydipsia (HP:0001959)2.60807266
27Abnormal drinking behavior (HP:0030082)2.60807266
28Abnormality of T cell physiology (HP:0011840)2.56942010
29Myositis (HP:0100614)2.56726692
30Increased corneal curvature (HP:0100692)2.52597292
31Keratoconus (HP:0000563)2.52597292
32Prostate neoplasm (HP:0100787)2.52500450
33Decreased circulating renin level (HP:0003351)2.50513940
34Pancreatic fibrosis (HP:0100732)2.43326835
35Methylmalonic acidemia (HP:0002912)2.40877574
36Abnormality of T cells (HP:0002843)2.39931229
37Optic neuritis (HP:0100653)2.37306686
38Retrobulbar optic neuritis (HP:0100654)2.37306686
39Abnormality of T cell number (HP:0011839)2.35411282
40Abnormality of the prostate (HP:0008775)2.35130108
41Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.31723593
42Absent phalangeal crease (HP:0006109)2.31574442
43Hepatic necrosis (HP:0002605)2.30225849
44Asplenia (HP:0001746)2.29930199
45Abnormality of eosinophils (HP:0001879)2.29445674
46Abnormality of the proximal phalanges of the hand (HP:0009834)2.28096882
47Poor head control (HP:0002421)2.24204217
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.23188586
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.21006858
50B lymphocytopenia (HP:0010976)2.20529766
51T lymphocytopenia (HP:0005403)2.17366539
52Aplasia/hypoplasia of the uterus (HP:0008684)2.17167244
53Progressive microcephaly (HP:0000253)2.14975532
54Clumsiness (HP:0002312)2.14463689
55Increased CSF lactate (HP:0002490)2.13137416
56Hypoplasia of the uterus (HP:0000013)2.11959482
57Pustule (HP:0200039)2.10393784
58Molar tooth sign on MRI (HP:0002419)2.09958509
59Abnormality of midbrain morphology (HP:0002418)2.09958509
60Orchitis (HP:0100796)2.09789153
61Nephronophthisis (HP:0000090)2.08070705
62Eosinophilia (HP:0001880)2.07200729
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.07183079
64Metabolic alkalosis (HP:0200114)2.06701738
65Hepatocellular necrosis (HP:0001404)2.05656413
66Abnormality of the phalanges of the 5th finger (HP:0004213)2.05355145
67Polyuria (HP:0000103)2.01845947
68Combined immunodeficiency (HP:0005387)2.01844076
69Autoimmune thrombocytopenia (HP:0001973)2.01474034
70Methylmalonic aciduria (HP:0012120)2.01213745
71Abnormality of the renal medulla (HP:0100957)2.00714411
72Conical tooth (HP:0000698)2.00116818
73Mitochondrial inheritance (HP:0001427)1.99720871
74Hypoproteinemia (HP:0003075)1.97216842
75Autoimmune hemolytic anemia (HP:0001890)1.95567185
76Abnormality of the nasal septum (HP:0000419)1.94091484
77True hermaphroditism (HP:0010459)1.93133845
78Congenital sensorineural hearing impairment (HP:0008527)1.92416637
79Short tibia (HP:0005736)1.91920852
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.91707329
81Abnormality of alanine metabolism (HP:0010916)1.84803662
82Hyperalaninemia (HP:0003348)1.84803662
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84803662
84Abnormality of vitamin B metabolism (HP:0004340)1.84787057
85Facial diplegia (HP:0001349)1.84469143
86Abnormality of the renal collecting system (HP:0004742)1.83675949
87Abnormal finger flexion creases (HP:0006143)1.83462699
88Abnormality of the vitamin B12 metabolism (HP:0004341)1.83015928
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82506035
90Lipid accumulation in hepatocytes (HP:0006561)1.82486746
91Pulmonary infiltrates (HP:0002113)1.82068788
92Dicarboxylic aciduria (HP:0003215)1.82041159
93Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82041159
94Bony spicule pigmentary retinopathy (HP:0007737)1.80344609
95Increased IgM level (HP:0003496)1.79960614
96Acute necrotizing encephalopathy (HP:0006965)1.79589605
97Abnormal respiratory motile cilium morphology (HP:0005938)1.78596451
98Abnormal respiratory epithelium morphology (HP:0012253)1.78596451
99Bile duct proliferation (HP:0001408)1.76586342
100Abnormal biliary tract physiology (HP:0012439)1.76586342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.67212350
2TXK4.11953174
3FRK3.47174593
4ADRBK23.23169923
5TLK13.18362034
6NUAK12.96515512
7GRK12.71478025
8MAP2K22.62448264
9PINK12.59923431
10BMPR1B2.58718939
11ZAK2.47085449
12ACVR1B2.09717505
13MAP4K21.80963922
14MAP4K11.74214453
15IKBKB1.65134300
16MAP3K141.62548539
17TIE11.51697146
18GRK61.47872151
19TEC1.42409016
20WNK41.40201587
21BRSK21.39141836
22ITK1.37652652
23MST41.32100148
24MAPKAPK31.31543766
25SYK1.31391330
26KDR1.19070622
27KIT1.18133469
28OXSR11.15342440
29AKT31.15305929
30BMPR21.14593989
31INSRR1.13104521
32TRPM71.11476352
33PHKG11.07936919
34PHKG21.07936919
35CDK81.06179518
36MYLK1.06003644
37GRK71.01765483
38IKBKE0.98456733
39DAPK20.95789033
40FES0.94711985
41PIK3CA0.94668377
42EIF2AK20.90708286
43JAK30.90571557
44GRK50.90341874
45MAP2K10.86479587
46NME10.85150746
47STK390.82916419
48TBK10.82358889
49ADRBK10.76982512
50ZAP700.76587564
51LCK0.76315187
52VRK20.74239594
53CHUK0.73029125
54MAP2K60.72582870
55EIF2AK30.70722755
56PTK2B0.70335611
57BTK0.69071529
58PRKCQ0.68862547
59PLK20.67934139
60FLT30.67219583
61IGF1R0.65642802
62TGFBR10.65630693
63LYN0.64374566
64PRKCE0.64253118
65PIK3CG0.59249839
66BCKDK0.59187927
67VRK10.58404371
68ERBB30.58151065
69PLK40.54428258
70CAMKK20.53844906
71HIPK20.53818995
72OBSCN0.53704876
73CSF1R0.53545879
74MAPK130.51099966
75MAPK110.49667535
76ABL10.48966226
77MUSK0.48588767
78MAPKAPK50.47345927
79DAPK10.47206432
80HCK0.46187696
81RIPK40.43403373
82CSNK1G30.41936793
83RPS6KA50.40989953
84WEE10.39646920
85CSNK1A10.38792889
86CSNK1A1L0.38743244
87JAK10.38522959
88MATK0.37986922
89MAP3K120.37890514
90WNK30.37699639
91PRKCA0.37395638
92CDK40.37307464
93TNK20.36276211
94PIM10.36207926
95CSNK1G20.34783552
96CHEK20.30414000
97PRKACA0.29348481
98CSNK1G10.27346933
99EPHA30.25506659
100DYRK20.23548175

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.89460362
2Asthma_Homo sapiens_hsa053103.64445454
3Allograft rejection_Homo sapiens_hsa053303.17629849
4Autoimmune thyroid disease_Homo sapiens_hsa053203.05672486
5Graft-versus-host disease_Homo sapiens_hsa053322.97672489
6Primary immunodeficiency_Homo sapiens_hsa053402.62231957
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59804973
8Type I diabetes mellitus_Homo sapiens_hsa049402.51162707
9Sulfur metabolism_Homo sapiens_hsa009202.45679131
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10420573
11Phototransduction_Homo sapiens_hsa047441.86648668
12Linoleic acid metabolism_Homo sapiens_hsa005911.81501188
13Nitrogen metabolism_Homo sapiens_hsa009101.76227572
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.70176774
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69809163
16Oxidative phosphorylation_Homo sapiens_hsa001901.68036823
17Antigen processing and presentation_Homo sapiens_hsa046121.60867904
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55959194
19Homologous recombination_Homo sapiens_hsa034401.54798828
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54268659
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51846455
22Rheumatoid arthritis_Homo sapiens_hsa053231.49676214
23Chemical carcinogenesis_Homo sapiens_hsa052041.47543125
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44630234
25One carbon pool by folate_Homo sapiens_hsa006701.43322754
26Arachidonic acid metabolism_Homo sapiens_hsa005901.38892461
27Tryptophan metabolism_Homo sapiens_hsa003801.37933474
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37811667
29Olfactory transduction_Homo sapiens_hsa047401.35096707
30Retinol metabolism_Homo sapiens_hsa008301.32041122
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28797793
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27246196
33Parkinsons disease_Homo sapiens_hsa050121.23598597
34Ether lipid metabolism_Homo sapiens_hsa005651.23070977
35Proteasome_Homo sapiens_hsa030501.21756206
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20679370
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19899922
38Protein export_Homo sapiens_hsa030601.19623870
39Selenocompound metabolism_Homo sapiens_hsa004501.19266446
40Caffeine metabolism_Homo sapiens_hsa002321.18764876
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.18618090
42Hematopoietic cell lineage_Homo sapiens_hsa046401.12934586
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06706116
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06583823
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05913615
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.05479515
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00962057
48RNA polymerase_Homo sapiens_hsa030200.95918411
49Staphylococcus aureus infection_Homo sapiens_hsa051500.95891462
50RNA degradation_Homo sapiens_hsa030180.94368633
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.92807718
52Leishmaniasis_Homo sapiens_hsa051400.89962978
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88675455
54T cell receptor signaling pathway_Homo sapiens_hsa046600.83814456
55Vitamin digestion and absorption_Homo sapiens_hsa049770.83527868
56Alzheimers disease_Homo sapiens_hsa050100.78651148
57Viral myocarditis_Homo sapiens_hsa054160.77863554
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77844544
59Butanoate metabolism_Homo sapiens_hsa006500.75375916
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74304166
61Peroxisome_Homo sapiens_hsa041460.74078482
62Fat digestion and absorption_Homo sapiens_hsa049750.73298341
63Taste transduction_Homo sapiens_hsa047420.67214520
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65496778
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65333581
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64211342
67Histidine metabolism_Homo sapiens_hsa003400.63846332
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.63320480
69Fanconi anemia pathway_Homo sapiens_hsa034600.63079652
70Mineral absorption_Homo sapiens_hsa049780.61565592
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.61305884
72Starch and sucrose metabolism_Homo sapiens_hsa005000.61019586
73Systemic lupus erythematosus_Homo sapiens_hsa053220.55537550
74ABC transporters_Homo sapiens_hsa020100.54490689
75Cardiac muscle contraction_Homo sapiens_hsa042600.54363343
76Purine metabolism_Homo sapiens_hsa002300.51021345
77Morphine addiction_Homo sapiens_hsa050320.50358040
78beta-Alanine metabolism_Homo sapiens_hsa004100.49479261
79Glycerolipid metabolism_Homo sapiens_hsa005610.47317706
80Insulin secretion_Homo sapiens_hsa049110.46217570
81Collecting duct acid secretion_Homo sapiens_hsa049660.46208881
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45417595
83Propanoate metabolism_Homo sapiens_hsa006400.44466087
84Serotonergic synapse_Homo sapiens_hsa047260.43977276
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43767988
86Renin secretion_Homo sapiens_hsa049240.43266301
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41457108
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39389523
89Herpes simplex infection_Homo sapiens_hsa051680.39167594
90Metabolic pathways_Homo sapiens_hsa011000.36142223
91Salivary secretion_Homo sapiens_hsa049700.35306621
92Huntingtons disease_Homo sapiens_hsa050160.34918478
93Nicotine addiction_Homo sapiens_hsa050330.34329470
94Basal transcription factors_Homo sapiens_hsa030220.33290324
95Sulfur relay system_Homo sapiens_hsa041220.32240793
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30307351
97Calcium signaling pathway_Homo sapiens_hsa040200.28601800
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27354566
99Renin-angiotensin system_Homo sapiens_hsa046140.26473357
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.26161939

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