MTCYBP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)7.57417476
2purine deoxyribonucleotide catabolic process (GO:0009155)6.23611120
3B cell mediated immunity (GO:0019724)6.02603521
4regulation of interleukin-8 secretion (GO:2000482)5.93097220
5negative regulation of inflammatory response to antigenic stimulus (GO:0002862)5.64290629
6nucleoside diphosphate catabolic process (GO:0009134)5.55774489
7regulation of nuclear cell cycle DNA replication (GO:0033262)5.27454247
8neutrophil mediated immunity (GO:0002446)5.15237193
9negative regulation of B cell apoptotic process (GO:0002903)4.98810200
10opsonization (GO:0008228)4.92896141
11positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.90354723
12chaperone mediated protein folding requiring cofactor (GO:0051085)4.77105708
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.60234873
14purine deoxyribonucleotide metabolic process (GO:0009151)4.34925511
15interferon-gamma-mediated signaling pathway (GO:0060333)4.31011047
16negative regulation of interleukin-8 production (GO:0032717)4.28595126
17regulation of interleukin-8 biosynthetic process (GO:0045414)4.27779783
18positive T cell selection (GO:0043368)4.19727204
19positive thymic T cell selection (GO:0045059)4.13121893
20regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.93642034
21regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.91127023
22myeloid leukocyte mediated immunity (GO:0002444)3.85716856
23mast cell activation (GO:0045576)3.85568144
24lipopolysaccharide biosynthetic process (GO:0009103)3.77130141
25response to interferon-alpha (GO:0035455)3.61430124
26purine ribonucleoside diphosphate metabolic process (GO:0009179)3.58257177
27purine nucleoside diphosphate metabolic process (GO:0009135)3.58257177
28regulation of cellular extravasation (GO:0002691)3.57940319
29positive regulation of DNA-dependent DNA replication (GO:2000105)3.57806097
30response to lead ion (GO:0010288)3.56901037
31positive regulation of prostaglandin secretion (GO:0032308)3.53394566
32positive regulation of antigen processing and presentation (GO:0002579)3.53357389
33deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.51559154
34tryptophan metabolic process (GO:0006568)3.41393178
35negative regulation of thymocyte apoptotic process (GO:0070244)3.37788200
36regulation of inflammatory response to antigenic stimulus (GO:0002861)3.36534143
37regulation of B cell apoptotic process (GO:0002902)3.34925078
38cellular response to interferon-gamma (GO:0071346)3.34279925
39T cell costimulation (GO:0031295)3.32813418
40lipopolysaccharide metabolic process (GO:0008653)3.32515439
41cellular response to interferon-alpha (GO:0035457)3.31327232
42lymphocyte costimulation (GO:0031294)3.27660694
43regulation of antigen processing and presentation (GO:0002577)3.26689929
44inflammatory response to antigenic stimulus (GO:0002437)3.25170069
45modulation of growth of symbiont involved in interaction with host (GO:0044144)3.25109553
46regulation of growth of symbiont in host (GO:0044126)3.25109553
47negative regulation of growth of symbiont in host (GO:0044130)3.25109553
48negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.25109553
49purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.25038490
50regulation of transforming growth factor beta1 production (GO:0032908)3.24189786
51negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.23129125
52positive regulation of fatty acid transport (GO:2000193)3.21897198
53response to interferon-gamma (GO:0034341)3.21238399
54lymphoid progenitor cell differentiation (GO:0002320)3.20208062
55negative regulation of neurotransmitter secretion (GO:0046929)3.16995799
56negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.15928119
57T cell activation involved in immune response (GO:0002286)3.14670726
58negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.12176706
59negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.11490715
60negative regulation of lymphocyte apoptotic process (GO:0070229)3.07619675
61indole-containing compound catabolic process (GO:0042436)3.00787985
62indolalkylamine catabolic process (GO:0046218)3.00787985
63tryptophan catabolic process (GO:0006569)3.00787985
64mature B cell differentiation involved in immune response (GO:0002313)2.98610552
65ribonucleoside diphosphate metabolic process (GO:0009185)2.96894449
66positive regulation of cell cycle G2/M phase transition (GO:1902751)2.96288371
67positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.96288371
68positive regulation of granulocyte differentiation (GO:0030854)2.96239659
69acute inflammatory response (GO:0002526)2.93068019
70protein K11-linked deubiquitination (GO:0035871)2.91803988
71killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.90229169
72disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.90229169
73cobalamin metabolic process (GO:0009235)2.88527323
74regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.87340127
75leukocyte mediated immunity (GO:0002443)2.85426801
76regulation of interleukin-4 production (GO:0032673)2.85368745
77mast cell degranulation (GO:0043303)2.85267759
78mast cell activation involved in immune response (GO:0002279)2.85267759
79regulation of prostaglandin secretion (GO:0032306)2.83727495
80regulation of cell proliferation involved in kidney development (GO:1901722)2.83704660
81anterograde synaptic vesicle transport (GO:0048490)2.80432563
82regulation of T cell tolerance induction (GO:0002664)2.79920894
83transcytosis (GO:0045056)2.78566301
84response to interferon-beta (GO:0035456)2.75393077
85production of molecular mediator of immune response (GO:0002440)2.74675994
86positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.74484696
87positive regulation of type 2 immune response (GO:0002830)2.73741102
88indolalkylamine metabolic process (GO:0006586)2.73614657
89detection of bacterium (GO:0016045)2.72141576
90negative thymic T cell selection (GO:0045060)2.69284106
91negative T cell selection (GO:0043383)2.67347642
92T-helper 1 type immune response (GO:0042088)2.66486652
93negative regulation of chemokine production (GO:0032682)2.65072916
94negative regulation of myeloid cell apoptotic process (GO:0033033)2.63376135
95lymphocyte mediated immunity (GO:0002449)2.61673007
96negative regulation of leukocyte apoptotic process (GO:2000107)2.61222225
97positive regulation of defense response to virus by host (GO:0002230)2.61165406
98reactive oxygen species biosynthetic process (GO:1903409)2.61034674
99regulation of interleukin-10 production (GO:0032653)2.58483960
100natural killer cell activation involved in immune response (GO:0002323)2.54099253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.57282352
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.21780250
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.16631901
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19910106
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89085294
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.85850883
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63039963
8RUNX_20019798_ChIP-Seq_JUKART_Human2.47616565
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.41713091
10SCL_19346495_ChIP-Seq_HPC-7_Human2.37304753
11ZNF274_21170338_ChIP-Seq_K562_Hela2.28482041
12EGR1_19032775_ChIP-ChIP_M12_Human2.14976425
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.11537974
14CIITA_25753668_ChIP-Seq_RAJI_Human1.96199734
15IRF8_21731497_ChIP-ChIP_J774_Mouse1.95472635
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.91296582
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84654427
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.82513217
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79129483
20MYB_26560356_Chip-Seq_TH2_Human1.74320497
21AHR_22903824_ChIP-Seq_MCF-7_Human1.73743297
22TP53_16413492_ChIP-PET_HCT116_Human1.69656300
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68413553
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.64237366
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60744783
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56183390
27VDR_22108803_ChIP-Seq_LS180_Human1.50884443
28RXR_22108803_ChIP-Seq_LS180_Human1.47376996
29GATA3_27048872_Chip-Seq_THYMUS_Human1.46973186
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46476403
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43185385
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39869227
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39869227
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38923496
35BCAT_22108803_ChIP-Seq_LS180_Human1.38331574
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37405762
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35541995
38FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35051885
39VDR_24787735_ChIP-Seq_THP-1_Human1.34462864
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.31046895
41GATA3_26560356_Chip-Seq_TH2_Human1.29712323
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23353857
43P300_19829295_ChIP-Seq_ESCs_Human1.23330889
44CBP_20019798_ChIP-Seq_JUKART_Human1.22359813
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22359813
46ER_23166858_ChIP-Seq_MCF-7_Human1.22270797
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21235695
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20046709
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19596979
50SPI1_23547873_ChIP-Seq_NB4_Human1.19235177
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18666716
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18503877
53ELK1_19687146_ChIP-ChIP_HELA_Human1.18226196
54VDR_23849224_ChIP-Seq_CD4+_Human1.17952307
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15035766
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14717289
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13215244
58RBPJ_21746931_ChIP-Seq_IB4_Human1.12060844
59GATA6_21074721_ChIP-Seq_CACO-2_Human1.10816494
60ERA_21632823_ChIP-Seq_H3396_Human1.10512695
61VDR_24763502_ChIP-Seq_THP-1_Human1.10403097
62SOX2_19829295_ChIP-Seq_ESCs_Human1.09550933
63NANOG_19829295_ChIP-Seq_ESCs_Human1.09550933
64AR_21572438_ChIP-Seq_LNCaP_Human1.09506038
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09245478
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09179950
67TAF15_26573619_Chip-Seq_HEK293_Human1.09154535
68TCF4_22108803_ChIP-Seq_LS180_Human1.07682192
69HNFA_21074721_ChIP-Seq_CACO-2_Human1.07132185
70PHF8_20622853_ChIP-Seq_HELA_Human1.06916523
71GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06611118
72SMRT_27268052_Chip-Seq_Bcells_Human1.04856066
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03980703
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02851764
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.02775530
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01631210
77EWS_26573619_Chip-Seq_HEK293_Human1.00924994
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.00664675
79MYB_26560356_Chip-Seq_TH1_Human1.00545588
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98795311
81AR_20517297_ChIP-Seq_VCAP_Human0.98213286
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98202913
83GATA3_26560356_Chip-Seq_TH1_Human0.98081096
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97987648
85SMAD4_21799915_ChIP-Seq_A2780_Human0.97747025
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95991881
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.95505034
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.94694426
89ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94484591
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94267481
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93740358
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93005358
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92859488
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92680862
95ETV1_20927104_ChIP-Seq_GIST48_Human0.92659311
96MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91932360
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91594210
98MYC_18940864_ChIP-ChIP_HL60_Human0.90873394
99STAT1_20625510_ChIP-Seq_HELA_Human0.90320458
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90280874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.26433486
2MP0002396_abnormal_hematopoietic_system4.17127951
3MP0001835_abnormal_antigen_presentation3.82446161
4MP0003195_calcinosis3.72629721
5MP0003183_abnormal_peptide_metabolism3.35020839
6MP0001873_stomach_inflammation2.89453335
7MP0005670_abnormal_white_adipose2.87105663
8MP0002009_preneoplasia2.86850206
9MP0005451_abnormal_body_composition2.59758783
10MP0002876_abnormal_thyroid_physiology2.54290156
11MP0003950_abnormal_plasma_membrane2.48492037
12MP0010386_abnormal_urinary_bladder2.30725976
13MP0003646_muscle_fatigue2.22373899
14MP0003300_gastrointestinal_ulcer2.19867288
15MP0001800_abnormal_humoral_immune2.05103364
16MP0002277_abnormal_respiratory_mucosa1.94626687
17MP0004147_increased_porphyrin_level1.89817957
18MP0002166_altered_tumor_susceptibility1.88860065
19MP0002163_abnormal_gland_morphology1.83676782
20MP0003724_increased_susceptibility_to1.79610336
21MP0008775_abnormal_heart_ventricle1.74406806
22MP0003763_abnormal_thymus_physiology1.68359241
23MP0008007_abnormal_cellular_replicative1.65555006
24MP0002928_abnormal_bile_duct1.64892851
25MP0001666_abnormal_nutrient_absorption1.63059720
26MP0002148_abnormal_hypersensitivity_rea1.61961846
27MP0002452_abnormal_antigen_presenting1.54792322
28MP0000372_irregular_coat_pigmentation1.54477838
29MP0005025_abnormal_response_to1.50938738
30MP0003866_abnormal_defecation1.49928864
31MP0004808_abnormal_hematopoietic_stem1.48719545
32MP0009785_altered_susceptibility_to1.44966843
33MP0003786_premature_aging1.44959002
34MP0005000_abnormal_immune_tolerance1.44362605
35MP0005646_abnormal_pituitary_gland1.44069355
36MP0000689_abnormal_spleen_morphology1.43484708
37MP0002420_abnormal_adaptive_immunity1.36919423
38MP0001819_abnormal_immune_cell1.35460278
39MP0005084_abnormal_gallbladder_morpholo1.35376034
40MP0008877_abnormal_DNA_methylation1.34684350
41MP0002332_abnormal_exercise_endurance1.33257355
42MP0000427_abnormal_hair_cycle1.33176256
43MP0002723_abnormal_immune_serum1.32872888
44MP0004043_abnormal_pH_regulation1.30237752
45MP0009278_abnormal_bone_marrow1.30036199
46MP0009764_decreased_sensitivity_to1.27965602
47MP0002006_tumorigenesis1.27461283
48MP0002419_abnormal_innate_immunity1.27193730
49MP0002282_abnormal_trachea_morphology1.26744966
50MP0002132_abnormal_respiratory_system1.24055759
51MP0001545_abnormal_hematopoietic_system1.21676625
52MP0005397_hematopoietic_system_phenotyp1.21676625
53MP0001853_heart_inflammation1.19116589
54MP0002398_abnormal_bone_marrow1.17546955
55MP0001845_abnormal_inflammatory_respons1.16806494
56MP0005365_abnormal_bile_salt1.16044812
57MP0000613_abnormal_salivary_gland1.15929812
58MP0005379_endocrine/exocrine_gland_phen1.12087191
59MP0001501_abnormal_sleep_pattern1.11979986
60MP0003943_abnormal_hepatobiliary_system1.11130783
61MP0000716_abnormal_immune_system1.10278453
62MP0006082_CNS_inflammation1.10094049
63MP0005408_hypopigmentation1.07487610
64MP0008995_early_reproductive_senescence1.06444424
65MP0005266_abnormal_metabolism1.05748337
66MP0004883_abnormal_blood_vessel1.04215742
67MP0008961_abnormal_basal_metabolism1.02655527
68MP0002722_abnormal_immune_system1.02462244
69MP0002405_respiratory_system_inflammati1.02433849
70MP0003868_abnormal_feces_composition1.00937312
71MP0005220_abnormal_exocrine_pancreas0.99569070
72MP0003252_abnormal_bile_duct0.94490961
73MP0003045_fibrosis0.94450136
74MP0000703_abnormal_thymus_morphology0.93637159
75MP0005164_abnormal_response_to0.91319866
76MP0002429_abnormal_blood_cell0.90525492
77MP0008875_abnormal_xenobiotic_pharmacok0.89932732
78MP0005165_increased_susceptibility_to0.89503840
79MP0008469_abnormal_protein_level0.87502472
80MP0004134_abnormal_chest_morphology0.86964997
81MP0009333_abnormal_splenocyte_physiolog0.86302652
82MP0005551_abnormal_eye_electrophysiolog0.86204120
83MP0000538_abnormal_urinary_bladder0.84136818
84MP0002938_white_spotting0.83609574
85MP0000639_abnormal_adrenal_gland0.80307782
86MP0002019_abnormal_tumor_incidence0.80223799
87MP0000569_abnormal_digit_pigmentation0.77849818
88MP0001790_abnormal_immune_system0.76542370
89MP0005387_immune_system_phenotype0.76542370
90MP0008058_abnormal_DNA_repair0.75218657
91MP0001502_abnormal_circadian_rhythm0.74262041
92MP0000631_abnormal_neuroendocrine_gland0.73991619
93MP0002138_abnormal_hepatobiliary_system0.70794970
94MP0005376_homeostasis/metabolism_phenot0.69798714
95MP0002102_abnormal_ear_morphology0.69004818
96MP0005645_abnormal_hypothalamus_physiol0.68873620
97MP0002998_abnormal_bone_remodeling0.67809662
98MP0003279_aneurysm0.65962053
99MP0005166_decreased_susceptibility_to0.64260973
100MP0000516_abnormal_urinary_system0.63710497

Predicted human phenotypes

RankGene SetZ-score
1Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)4.58028649
2Abnormality of the prostate (HP:0008775)4.41549826
3Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)4.19406765
4Glucose intolerance (HP:0000833)4.16902282
5Acute lymphatic leukemia (HP:0006721)4.04957042
6Abnormality of the parietal bone (HP:0002696)3.83851861
7Abnormality involving the epiphyses of the upper limbs (HP:0003839)3.65972870
8Metaphyseal dysplasia (HP:0100255)3.60057153
9Abnormality of the epiphyses of the hand (HP:0005924)3.57447079
10Spondylolisthesis (HP:0003302)3.55669599
11Ureteral stenosis (HP:0000071)3.52450720
12Birth length less than 3rd percentile (HP:0003561)3.52356292
13Ureteral obstruction (HP:0006000)3.27671343
14Abnormality of male internal genitalia (HP:0000022)3.25746223
15Ileus (HP:0002595)3.12996507
16Pulmonary fibrosis (HP:0002206)3.11958142
17Neoplasm of the tracheobronchial system (HP:0100552)2.86113133
18Stomach cancer (HP:0012126)2.84806765
19Pulmonary infiltrates (HP:0002113)2.83956373
20Abnormal glucose tolerance (HP:0001952)2.74049274
21Abnormal delayed hypersensitivity skin test (HP:0002963)2.64803708
22Mediastinal lymphadenopathy (HP:0100721)2.59318607
23Elevated erythrocyte sedimentation rate (HP:0003565)2.58514835
24Abnormality of the pleura (HP:0002103)2.57722708
25Hypoplastic iliac wings (HP:0002866)2.55127567
26Abnormal protein glycosylation (HP:0012346)2.52211422
27Abnormal glycosylation (HP:0012345)2.52211422
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52211422
29Abnormal protein N-linked glycosylation (HP:0012347)2.52211422
30Alveolar cell carcinoma (HP:0006519)2.49187120
31Adrenal hypoplasia (HP:0000835)2.48361866
32Abnormality of macular pigmentation (HP:0008002)2.41702862
33Xerostomia (HP:0000217)2.40941068
34Thrombocytosis (HP:0001894)2.40408035
35Prostate neoplasm (HP:0100787)2.40047601
36Short middle phalanx of the 5th finger (HP:0004220)2.34704316
37Meningitis (HP:0001287)2.33987098
38Congenital stationary night blindness (HP:0007642)2.33950781
39Hyperventilation (HP:0002883)2.32326294
40Decreased central vision (HP:0007663)2.26603388
41Dysostosis multiplex (HP:0000943)2.26356317
42Parakeratosis (HP:0001036)2.22385705
43Colitis (HP:0002583)2.21598341
44Exocrine pancreatic insufficiency (HP:0001738)2.18906845
45Supernumerary bones of the axial skeleton (HP:0009144)2.17913079
46Chronic sinusitis (HP:0011109)2.16271397
47Obstructive lung disease (HP:0006536)2.14901867
48Chronic obstructive pulmonary disease (HP:0006510)2.14901867
49Acute myeloid leukemia (HP:0004808)2.14708846
50Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14024859
51Large eyes (HP:0001090)2.12911024
52Panhypogammaglobulinemia (HP:0003139)2.11307519
53Abnormality of the sella turcica (HP:0002679)2.09650563
54Abnormality of Sharpey fibers (HP:0100685)2.07484175
5511 pairs of ribs (HP:0000878)2.07172396
56Chest pain (HP:0100749)2.06656899
57Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06293138
58Abnormality of liposaccharide metabolism (HP:0010968)2.06278001
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.06278001
60Abnormality of glycolipid metabolism (HP:0010969)2.06278001
61Recurrent pneumonia (HP:0006532)2.04303620
62Chondrocalcinosis (HP:0000934)2.03686581
63Febrile seizures (HP:0002373)2.03388789
64Spontaneous abortion (HP:0005268)2.02845717
65Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99342443
66Abnormality of the renal cortex (HP:0011035)1.95886055
67Type I transferrin isoform profile (HP:0003642)1.94785744
68Macular degeneration (HP:0000608)1.94166853
69Gaze-evoked nystagmus (HP:0000640)1.94058919
70Supernumerary ribs (HP:0005815)1.94023233
71Deformed sella turcica (HP:0002681)1.91963367
72Abnormality of T cell physiology (HP:0011840)1.90992435
73Hypoplastic scapulae (HP:0000882)1.89949695
74Aplasia/Hypoplasia of the scapulae (HP:0006713)1.89949695
75Recurrent abscess formation (HP:0002722)1.87926820
76Abnormality of the nasal septum (HP:0000419)1.87646640
77Abnormality of skull ossification (HP:0002703)1.87018766
78Urticaria (HP:0001025)1.85633206
79Aplasia of the musculature (HP:0100854)1.83650140
80Abnormality of the renal medulla (HP:0100957)1.83200562
81Volvulus (HP:0002580)1.82043644
82Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81715188
83Abnormality of polysaccharide metabolism (HP:0011012)1.81715188
84Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81715188
85Recurrent bronchitis (HP:0002837)1.79644731
86Mucopolysacchariduria (HP:0008155)1.77938715
87Urinary glycosaminoglycan excretion (HP:0003541)1.77938715
88Hemoptysis (HP:0002105)1.77244238
89Hypoplastic labia majora (HP:0000059)1.77159624
90Increased number of teeth (HP:0011069)1.76393060
91Epiphyseal stippling (HP:0010655)1.76256586
92Abnormality of the pericardium (HP:0001697)1.75455771
93Eosinophilia (HP:0001880)1.74868486
94Stomatitis (HP:0010280)1.74533874
95Lip pit (HP:0100267)1.73596811
96Microretrognathia (HP:0000308)1.72406440
97Progressive microcephaly (HP:0000253)1.72147816
98Granulocytopenia (HP:0001913)1.71979971
99Cone-rod dystrophy (HP:0000548)1.71935551
100Abnormality of chloride homeostasis (HP:0011422)1.70331352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR25.09028268
2FLT34.82360035
3PIK3CG3.63484425
4AKT33.56700811
5KIT3.55201489
6BMPR1B3.06169344
7LMTK22.91063180
8INSRR2.37840346
9FRK2.23322925
10TXK2.04789402
11CDK122.02659090
12ARAF2.01752482
13PIM21.98466153
14TLK11.94868422
15MST41.74565114
16STK391.62178615
17KDR1.61812829
18ACVR1B1.57368872
19CSF1R1.53804677
20MAP4K11.44793044
21ZAK1.43057338
22PDK21.42297326
23TEC1.41715315
24NUAK11.38794166
25GRK11.34678212
26ADRBK21.34600775
27IRAK41.25701841
28EIF2AK31.23103244
29NME21.17846151
30CDK81.15751760
31PIK3CA1.14553649
32BRAF1.11618102
33VRK11.10587681
34PRKCQ1.08829069
35VRK21.06759484
36STK241.04031339
37BRD40.99620741
38TYK20.98630211
39PTK2B0.98061337
40IKBKB0.97668698
41TRPM70.97470179
42RIPK40.87178570
43CSNK1A1L0.86983237
44IKBKE0.85588752
45TAOK30.84638963
46SYK0.84274354
47OXSR10.82747994
48TIE10.77042646
49CSNK1G10.74935663
50CHUK0.74425450
51CSNK1G30.72812078
52ZAP700.67912611
53NME10.67746828
54TNK20.66433398
55TRIM280.65590765
56TESK20.64483745
57PIM10.62302863
58SGK20.61729529
59ERBB20.61697459
60ILK0.60354298
61NLK0.59905825
62LYN0.55469891
63EIF2AK20.54884439
64ERBB30.52553249
65MAPK70.52221806
66JAK30.51941977
67HIPK20.51025903
68CAMK1G0.50548796
69RPS6KA50.50101372
70CSNK1G20.49565839
71ATR0.48710504
72PINK10.48671498
73WNK40.45532581
74CDK90.44780048
75TGFBR10.43881356
76PHKG20.42165137
77PHKG10.42165137
78RAF10.40063484
79MELK0.39436762
80PRKCE0.37193132
81PNCK0.37036470
82PLK40.36939720
83WNK10.35483278
84ADRBK10.34750943
85ROCK10.34434089
86IGF1R0.34042799
87LCK0.33432812
88PRKG10.32740596
89MAP3K140.32594226
90PKN10.31281697
91BRSK20.28309617
92TAF10.28051217
93FES0.27789215
94MAPK110.26636693
95CSNK1D0.26384009
96PRKCD0.25700552
97CAMKK20.24812928
98TGFBR20.24020650
99PRKCI0.23762703
100CDK30.23229825

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.44409978
2Allograft rejection_Homo sapiens_hsa053305.20341964
3Graft-versus-host disease_Homo sapiens_hsa053324.95012419
4Autoimmune thyroid disease_Homo sapiens_hsa053204.94675377
5Intestinal immune network for IgA production_Homo sapiens_hsa046724.43381682
6Type I diabetes mellitus_Homo sapiens_hsa049404.36050938
7Viral myocarditis_Homo sapiens_hsa054163.14231698
8Staphylococcus aureus infection_Homo sapiens_hsa051502.99288962
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.86909908
10Antigen processing and presentation_Homo sapiens_hsa046122.54881944
11Leishmaniasis_Homo sapiens_hsa051402.33640407
12Rheumatoid arthritis_Homo sapiens_hsa053232.26927289
13Hematopoietic cell lineage_Homo sapiens_hsa046402.22659972
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.58203008
15Systemic lupus erythematosus_Homo sapiens_hsa053221.54314638
16Influenza A_Homo sapiens_hsa051641.38507147
17Circadian rhythm_Homo sapiens_hsa047101.35736105
18Herpes simplex infection_Homo sapiens_hsa051681.32792941
19Toxoplasmosis_Homo sapiens_hsa051451.30428552
20Tuberculosis_Homo sapiens_hsa051521.29556629
21Pancreatic secretion_Homo sapiens_hsa049721.23648819
22Fatty acid biosynthesis_Homo sapiens_hsa000610.95762936
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85677062
24Glutathione metabolism_Homo sapiens_hsa004800.76760036
25Phototransduction_Homo sapiens_hsa047440.75828182
26Oxidative phosphorylation_Homo sapiens_hsa001900.72441923
27Sphingolipid metabolism_Homo sapiens_hsa006000.70110615
28RNA polymerase_Homo sapiens_hsa030200.69595280
29Ribosome_Homo sapiens_hsa030100.68105116
30Peroxisome_Homo sapiens_hsa041460.64988046
31Phagosome_Homo sapiens_hsa041450.64982690
32Glycosaminoglycan degradation_Homo sapiens_hsa005310.60100960
33Epstein-Barr virus infection_Homo sapiens_hsa051690.59776960
34Non-homologous end-joining_Homo sapiens_hsa034500.57381256
35SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54880873
36RNA degradation_Homo sapiens_hsa030180.54764366
37Primary immunodeficiency_Homo sapiens_hsa053400.54634802
38Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52990939
39Tryptophan metabolism_Homo sapiens_hsa003800.50682533
40Fat digestion and absorption_Homo sapiens_hsa049750.49985461
41Huntingtons disease_Homo sapiens_hsa050160.47732996
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45213290
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43294327
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.41817343
45Measles_Homo sapiens_hsa051620.40267980
46Homologous recombination_Homo sapiens_hsa034400.39917709
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39738333
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.38177924
49One carbon pool by folate_Homo sapiens_hsa006700.37291119
50Fanconi anemia pathway_Homo sapiens_hsa034600.36836571
51Protein export_Homo sapiens_hsa030600.36358680
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35877724
53Salivary secretion_Homo sapiens_hsa049700.33294507
54Chemical carcinogenesis_Homo sapiens_hsa052040.32751797
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.32661485
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32523265
57Thyroid hormone synthesis_Homo sapiens_hsa049180.32389729
58Butanoate metabolism_Homo sapiens_hsa006500.31922136
59Acute myeloid leukemia_Homo sapiens_hsa052210.31736114
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.31167456
61HTLV-I infection_Homo sapiens_hsa051660.31116476
62Parkinsons disease_Homo sapiens_hsa050120.30757453
63Pyrimidine metabolism_Homo sapiens_hsa002400.30395395
64Linoleic acid metabolism_Homo sapiens_hsa005910.29967787
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.29966477
66TNF signaling pathway_Homo sapiens_hsa046680.29765181
67Hepatitis C_Homo sapiens_hsa051600.29747449
68Lysine degradation_Homo sapiens_hsa003100.29226565
69Glycerolipid metabolism_Homo sapiens_hsa005610.28979954
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27483926
71Arachidonic acid metabolism_Homo sapiens_hsa005900.26309046
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25771407
73B cell receptor signaling pathway_Homo sapiens_hsa046620.24881365
74Alzheimers disease_Homo sapiens_hsa050100.22940857
75Protein digestion and absorption_Homo sapiens_hsa049740.22715231
76Purine metabolism_Homo sapiens_hsa002300.22568022
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21566783
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20475029
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20314209
80T cell receptor signaling pathway_Homo sapiens_hsa046600.20041391
81Ether lipid metabolism_Homo sapiens_hsa005650.17041205
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16689264
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14952748
84Malaria_Homo sapiens_hsa051440.14139240
85Caffeine metabolism_Homo sapiens_hsa002320.14067395
86Regulation of autophagy_Homo sapiens_hsa041400.12695218
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.12366361
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11533167
89Steroid biosynthesis_Homo sapiens_hsa001000.11331133
90Fatty acid degradation_Homo sapiens_hsa000710.10688708
91Lysosome_Homo sapiens_hsa041420.10634463
92Fatty acid metabolism_Homo sapiens_hsa012120.09213726
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09087160
94Basal transcription factors_Homo sapiens_hsa030220.08603120
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08387591
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08076984
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07660356
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.05406471
99ABC transporters_Homo sapiens_hsa020100.05267666
100Proteasome_Homo sapiens_hsa030500.05002555

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