MTERF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.22337762
2ATP synthesis coupled proton transport (GO:0015986)5.76115921
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.76115921
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.07537189
5respiratory electron transport chain (GO:0022904)4.93408123
6electron transport chain (GO:0022900)4.88067604
7response to pheromone (GO:0019236)4.42220175
8protein complex biogenesis (GO:0070271)4.33218814
9oxidative phosphorylation (GO:0006119)4.23527544
10neuron cell-cell adhesion (GO:0007158)4.22240901
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.19861892
12NADH dehydrogenase complex assembly (GO:0010257)4.19861892
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.19861892
14chaperone-mediated protein transport (GO:0072321)4.01664428
15mitochondrial respiratory chain complex assembly (GO:0033108)4.01592981
16cullin deneddylation (GO:0010388)3.90243294
17tricarboxylic acid cycle (GO:0006099)3.86948802
18synaptic transmission, dopaminergic (GO:0001963)3.85147272
19vocalization behavior (GO:0071625)3.70590239
20nucleoside transmembrane transport (GO:1901642)3.68228495
21GDP-mannose metabolic process (GO:0019673)3.67715871
22dopamine transport (GO:0015872)3.66548510
23regulation of hexokinase activity (GO:1903299)3.62238606
24regulation of glucokinase activity (GO:0033131)3.62238606
25axoneme assembly (GO:0035082)3.60594124
26synaptic vesicle exocytosis (GO:0016079)3.59882988
27regulation of relaxation of muscle (GO:1901077)3.59161574
28succinate metabolic process (GO:0006105)3.49227007
29striatum development (GO:0021756)3.45907643
30protein localization to synapse (GO:0035418)3.44037642
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.39837863
32water-soluble vitamin biosynthetic process (GO:0042364)3.35706587
33short-chain fatty acid metabolic process (GO:0046459)3.34115657
34ATP biosynthetic process (GO:0006754)3.34081911
35nonmotile primary cilium assembly (GO:0035058)3.32313124
36inositol phosphate catabolic process (GO:0071545)3.30435163
37mannose metabolic process (GO:0006013)3.29335215
38protein localization to cilium (GO:0061512)3.28414995
39regulation of protein kinase A signaling (GO:0010738)3.27961625
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.26081323
41protein deneddylation (GO:0000338)3.25995738
42glutamate secretion (GO:0014047)3.25605243
43regulation of acyl-CoA biosynthetic process (GO:0050812)3.24422109
44negative regulation of microtubule polymerization (GO:0031115)3.24325043
45regulation of mitochondrial translation (GO:0070129)3.22222776
46regulation of synaptic vesicle exocytosis (GO:2000300)3.19329804
47catecholamine transport (GO:0051937)3.17956761
48adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.15910722
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.15182967
50cellular ketone body metabolic process (GO:0046950)3.13508263
51regulation of short-term neuronal synaptic plasticity (GO:0048172)3.13202556
52behavioral response to cocaine (GO:0048148)3.12647289
53purine nucleoside triphosphate biosynthetic process (GO:0009145)3.11074504
54establishment of integrated proviral latency (GO:0075713)3.10506996
55hydrogen ion transmembrane transport (GO:1902600)3.10445513
56monoubiquitinated protein deubiquitination (GO:0035520)3.06055165
57inositol phosphate dephosphorylation (GO:0046855)3.03445494
58phosphorylated carbohydrate dephosphorylation (GO:0046838)3.03445494
59mating behavior (GO:0007617)3.03024394
60synaptic vesicle docking involved in exocytosis (GO:0016081)3.02339383
61regulation of cofactor metabolic process (GO:0051193)3.01597777
62regulation of coenzyme metabolic process (GO:0051196)3.01597777
63negative regulation of cAMP-mediated signaling (GO:0043951)3.00329281
64neurotransmitter secretion (GO:0007269)2.99547918
65respiratory chain complex IV assembly (GO:0008535)2.99241383
66inner mitochondrial membrane organization (GO:0007007)2.98702127
67positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.98593824
68protein neddylation (GO:0045116)2.98181455
69regulation of synapse structural plasticity (GO:0051823)2.98121349
70ATP hydrolysis coupled proton transport (GO:0015991)2.97370091
71energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.97370091
72brain morphogenesis (GO:0048854)2.97355267
73regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.97186915
74neurotransmitter catabolic process (GO:0042135)2.96960872
75peroxisome fission (GO:0016559)2.95324065
76regulation of cilium movement (GO:0003352)2.94203770
77regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.93641250
78regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.93641250
79regulation of neurotransmitter uptake (GO:0051580)2.91272500
80regulation of cell communication by electrical coupling (GO:0010649)2.91192881
81glycerophospholipid catabolic process (GO:0046475)2.91140916
82positive regulation of neurotransmitter transport (GO:0051590)2.89881193
83NADH metabolic process (GO:0006734)2.89537006
84neuron-neuron synaptic transmission (GO:0007270)2.89453729
85negative regulation of dendrite development (GO:2000171)2.88571198
86regulation of glutamate receptor signaling pathway (GO:1900449)2.88360365
87cilium morphogenesis (GO:0060271)2.87698622
88behavioral response to ethanol (GO:0048149)2.87440403
89negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86398525
90positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.85570308
91regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.85387078
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82812562
93mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.82285908
94ribonucleoside triphosphate biosynthetic process (GO:0009201)2.81893782
95ketone body metabolic process (GO:1902224)2.81329332
96cytochrome complex assembly (GO:0017004)2.81210962
97regulation of synaptic vesicle transport (GO:1902803)2.80548325
98histone H2A acetylation (GO:0043968)2.75354779
99cofactor transport (GO:0051181)2.74305182
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72594987
101positive regulation of neurotransmitter secretion (GO:0001956)2.72061667
102maternal behavior (GO:0042711)2.71860812
103proton transport (GO:0015992)2.71715646
104nephron tubule morphogenesis (GO:0072078)2.71622543
105nephron epithelium morphogenesis (GO:0072088)2.71622543
106regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.70697587
107regulation of oxidative phosphorylation (GO:0002082)2.69897566
108presynaptic membrane assembly (GO:0097105)2.69505994
109nucleoside transport (GO:0015858)2.68672691
110behavioral response to nicotine (GO:0035095)2.68146341
111neuron recognition (GO:0008038)2.66965232
112endocrine pancreas development (GO:0031018)2.66943751
113sphingomyelin metabolic process (GO:0006684)2.66322038
114hydrogen transport (GO:0006818)2.66303550
115regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.64903168
116oxaloacetate metabolic process (GO:0006107)2.63892510
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.63524360
118regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63469320
119detection of calcium ion (GO:0005513)2.63415074
120urinary tract smooth muscle contraction (GO:0014848)2.61552699
121regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.61395673
122aerobic respiration (GO:0009060)2.59336351
123establishment of viral latency (GO:0019043)2.59059585
124otic vesicle formation (GO:0030916)2.57993648
125regulation of catecholamine metabolic process (GO:0042069)2.56188421
126regulation of dopamine metabolic process (GO:0042053)2.56188421
127cellular response to leptin stimulus (GO:0044320)2.56105656
128artery smooth muscle contraction (GO:0014824)2.56067891
129prepulse inhibition (GO:0060134)2.55042273
130postsynaptic membrane organization (GO:0001941)2.54965371
131regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.54906813
132neuromuscular synaptic transmission (GO:0007274)2.54533715
133response to histamine (GO:0034776)2.54378911
134photoreceptor cell maintenance (GO:0045494)2.54348604
135positive regulation of glycolytic process (GO:0045821)2.53765193
136regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53362981
137positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52914071
138regulation of action potential (GO:0098900)2.51851463
139positive regulation of synapse assembly (GO:0051965)2.51655171
140positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.50697186
141ribonucleoprotein complex disassembly (GO:0032988)2.50092417
142negative regulation of execution phase of apoptosis (GO:1900118)2.49832083
143dopamine biosynthetic process (GO:0042416)2.49372168
144intraciliary transport (GO:0042073)2.49317943
145GTP biosynthetic process (GO:0006183)2.49036665
146hindbrain development (GO:0030902)2.48101604
147L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47707249
148protein prenylation (GO:0018342)2.46395961
149prenylation (GO:0097354)2.46395961
150phospholipid catabolic process (GO:0009395)2.44954512
151branched-chain amino acid catabolic process (GO:0009083)2.43633021
152cilium organization (GO:0044782)2.43408392
153glycosphingolipid biosynthetic process (GO:0006688)2.42123476
154cilium assembly (GO:0042384)2.41807708
155establishment of protein localization to peroxisome (GO:0072663)2.40882271
156protein localization to peroxisome (GO:0072662)2.40882271
157protein targeting to peroxisome (GO:0006625)2.40882271
158protein polyglutamylation (GO:0018095)2.40736083
159negative regulation of dendrite morphogenesis (GO:0050774)2.40631841
160cornea development in camera-type eye (GO:0061303)2.40217258
161polyol catabolic process (GO:0046174)2.39962696
162regulation of heart rate by cardiac conduction (GO:0086091)2.39716185
163protein K11-linked deubiquitination (GO:0035871)2.36250170
164nucleobase catabolic process (GO:0046113)2.36167204
165coenzyme A biosynthetic process (GO:0015937)2.36159786
166ubiquinone biosynthetic process (GO:0006744)2.35812020
167ubiquinone metabolic process (GO:0006743)2.35349450
168tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.32935974
169RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.32935974
170auditory receptor cell differentiation (GO:0042491)2.32014075
171pyrimidine nucleobase catabolic process (GO:0006208)2.31603983
172insulin secretion (GO:0030073)2.30286399
173cardiac conduction (GO:0061337)2.28694576
174peroxisome organization (GO:0007031)2.28215602
175coenzyme A metabolic process (GO:0015936)2.27690134
176protein localization to Golgi apparatus (GO:0034067)2.25967957
177vascular smooth muscle contraction (GO:0014829)2.25895918
178regulation of glycogen (starch) synthase activity (GO:2000465)2.24390314
179negative regulation of appetite (GO:0032099)2.24016511
180negative regulation of response to food (GO:0032096)2.24016511
181melanosome transport (GO:0032402)2.22534417
182retinal ganglion cell axon guidance (GO:0031290)2.22505331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.14832409
2GBX2_23144817_ChIP-Seq_PC3_Human3.89049424
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.19624985
4TAF15_26573619_Chip-Seq_HEK293_Human3.04636146
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.58670889
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56811763
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56302042
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35071452
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32209216
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23881210
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.18608418
12REST_21632747_ChIP-Seq_MESCs_Mouse2.16637099
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15389710
14ZNF274_21170338_ChIP-Seq_K562_Hela2.06016073
15FUS_26573619_Chip-Seq_HEK293_Human2.01402734
16GABP_17652178_ChIP-ChIP_JURKAT_Human1.98473945
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98272055
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98026046
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95694270
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95348570
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95275551
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93613831
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90088628
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88070483
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84860271
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.81393977
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81025643
28P300_19829295_ChIP-Seq_ESCs_Human1.80872499
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74589949
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.73194790
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71981891
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70550142
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.69128454
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.68631100
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65928669
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65928669
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65924999
38VDR_22108803_ChIP-Seq_LS180_Human1.64837087
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63131495
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.61825734
41SMAD4_21799915_ChIP-Seq_A2780_Human1.56185226
42IGF1R_20145208_ChIP-Seq_DFB_Human1.56127843
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55289605
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54445954
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53563794
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49319772
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.49179172
48STAT3_23295773_ChIP-Seq_U87_Human1.47863557
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.46341557
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46095314
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45831527
52AR_21572438_ChIP-Seq_LNCaP_Human1.45667960
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43846274
54HTT_18923047_ChIP-ChIP_STHdh_Human1.43815476
55FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.42617890
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41652466
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38328067
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.38191820
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37496544
60EWS_26573619_Chip-Seq_HEK293_Human1.36499961
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34541981
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34399664
63RNF2_27304074_Chip-Seq_NSC_Mouse1.34081517
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33251594
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32761837
66ER_23166858_ChIP-Seq_MCF-7_Human1.32260326
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.31775465
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31042318
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30542234
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28702956
71TCF4_23295773_ChIP-Seq_U87_Human1.27582047
72TCF4_22108803_ChIP-Seq_LS180_Human1.27143768
73CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.26977849
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26674817
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26087213
76RUNX2_22187159_ChIP-Seq_PCA_Human1.24777274
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.24111866
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.24099823
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23747025
80TP53_22573176_ChIP-Seq_HFKS_Human1.23332981
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22894935
82IRF1_19129219_ChIP-ChIP_H3396_Human1.22555236
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.22268949
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21186656
85ELK1_19687146_ChIP-ChIP_HELA_Human1.20943480
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.20760363
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20254682
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19807851
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18952053
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18614374
91ETS1_20019798_ChIP-Seq_JURKAT_Human1.18547994
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17920115
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17655464
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16997606
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16816382
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14425333
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14234003
98PHF8_20622853_ChIP-Seq_HELA_Human1.13416311
99SOX2_19829295_ChIP-Seq_ESCs_Human1.12571994
100NANOG_19829295_ChIP-Seq_ESCs_Human1.12571994
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12406185
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.11209640
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10186766
104JUN_21703547_ChIP-Seq_K562_Human1.09975385
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09718697
106SOX9_26525672_Chip-Seq_HEART_Mouse1.09392218
107CDX2_22108803_ChIP-Seq_LS180_Human1.08954948
108TBL1_22424771_ChIP-Seq_293T_Human1.08206124
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.08018958
110BCAT_22108803_ChIP-Seq_LS180_Human1.07469920
111NFYB_21822215_ChIP-Seq_K562_Human1.06435578
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06088854
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06002736
114FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05732328
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.05732328
116GATA1_22025678_ChIP-Seq_K562_Human1.05581582
117NFYA_21822215_ChIP-Seq_K562_Human1.05418052
118REST_19997604_ChIP-ChIP_NEURONS_Mouse1.04682977
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04443840
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.04051964
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03667791
122RNF2_27304074_Chip-Seq_ESCs_Mouse1.02474708
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01187974
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00568745
125SOX2_21211035_ChIP-Seq_LN229_Gbm1.00085800
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99939901
127EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98741488
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98602992
129CBP_20019798_ChIP-Seq_JUKART_Human0.98602992
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.97385374
131IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95987049
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.95067668
133P53_22387025_ChIP-Seq_ESCs_Mouse0.94579799
134AR_25329375_ChIP-Seq_VCAP_Human0.94563328
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94562427
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94417960
137PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94417519
138VDR_23849224_ChIP-Seq_CD4+_Human0.94381038
139E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93255326
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93102838
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93102838
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92598184
143NOTCH1_21737748_ChIP-Seq_TLL_Human0.92586630
144DROSHA_22980978_ChIP-Seq_HELA_Human0.90522802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.07074861
2MP0002822_catalepsy3.81983006
3MP0004859_abnormal_synaptic_plasticity3.28606122
4MP0001529_abnormal_vocalization2.75056731
5MP0003635_abnormal_synaptic_transmissio2.73779907
6MP0002837_dystrophic_cardiac_calcinosis2.65756399
7MP0006276_abnormal_autonomic_nervous2.55393794
8MP0002735_abnormal_chemical_nociception2.53370147
9MP0004270_analgesia2.51808197
10MP0001968_abnormal_touch/_nociception2.50713336
11MP0009745_abnormal_behavioral_response2.49666817
12MP0002736_abnormal_nociception_after2.37966005
13MP0002063_abnormal_learning/memory/cond2.30465079
14MP0003195_calcinosis2.27981745
15MP0004215_abnormal_myocardial_fiber2.22915387
16MP0003122_maternal_imprinting2.21743713
17MP0004043_abnormal_pH_regulation2.21363440
18MP0002064_seizures2.20218823
19MP0005423_abnormal_somatic_nervous2.17029069
20MP0002272_abnormal_nervous_system2.16332596
21MP0000751_myopathy2.15923567
22MP0002572_abnormal_emotion/affect_behav2.12786539
23MP0002734_abnormal_mechanical_nocicepti2.12785122
24MP0003646_muscle_fatigue2.09936389
25MP0001905_abnormal_dopamine_level2.06009439
26MP0001984_abnormal_olfaction2.03209946
27MP0002184_abnormal_innervation2.01968379
28MP0001440_abnormal_grooming_behavior1.93689563
29MP0005253_abnormal_eye_physiology1.90135530
30MP0009046_muscle_twitch1.85879215
31MP0004142_abnormal_muscle_tone1.79339298
32MP0005379_endocrine/exocrine_gland_phen1.77137278
33MP0002254_reproductive_system_inflammat1.76326549
34MP0002067_abnormal_sensory_capabilities1.74166634
35MP0001944_abnormal_pancreas_morphology1.73338424
36MP0004145_abnormal_muscle_electrophysio1.72563613
37MP0001188_hyperpigmentation1.71572834
38MP0000749_muscle_degeneration1.71543044
39MP0000778_abnormal_nervous_system1.70667683
40MP0002876_abnormal_thyroid_physiology1.69823210
41MP0004036_abnormal_muscle_relaxation1.69660265
42MP0005499_abnormal_olfactory_system1.69269623
43MP0005394_taste/olfaction_phenotype1.69269623
44MP0008789_abnormal_olfactory_epithelium1.68160089
45MP0004147_increased_porphyrin_level1.66165653
46MP0005646_abnormal_pituitary_gland1.60792251
47MP0001486_abnormal_startle_reflex1.58577570
48MP0002139_abnormal_hepatobiliary_system1.57140704
49MP0002163_abnormal_gland_morphology1.56143220
50MP0005386_behavior/neurological_phenoty1.55876372
51MP0004924_abnormal_behavior1.55876372
52MP0006036_abnormal_mitochondrial_physio1.55129248
53MP0002733_abnormal_thermal_nociception1.52022695
54MP0000569_abnormal_digit_pigmentation1.50838332
55MP0002557_abnormal_social/conspecific_i1.50537185
56MP0004085_abnormal_heartbeat1.49732526
57MP0006035_abnormal_mitochondrial_morpho1.48348440
58MP0004084_abnormal_cardiac_muscle1.47440722
59MP0001501_abnormal_sleep_pattern1.42471619
60MP0001970_abnormal_pain_threshold1.42422650
61MP0005645_abnormal_hypothalamus_physiol1.42352392
62MP0010386_abnormal_urinary_bladder1.41526343
63MP0002971_abnormal_brown_adipose1.30440715
64MP0002638_abnormal_pupillary_reflex1.28816912
65MP0005220_abnormal_exocrine_pancreas1.28529480
66MP0002090_abnormal_vision1.28227132
67MP0009780_abnormal_chondrocyte_physiolo1.25514238
68MP0002295_abnormal_pulmonary_circulatio1.23911978
69MP0000955_abnormal_spinal_cord1.23379482
70MP0004885_abnormal_endolymph1.22903881
71MP0000631_abnormal_neuroendocrine_gland1.22865617
72MP0003137_abnormal_impulse_conducting1.22313563
73MP0008569_lethality_at_weaning1.21256969
74MP0004811_abnormal_neuron_physiology1.19420641
75MP0002751_abnormal_autonomic_nervous1.18915211
76MP0006072_abnormal_retinal_apoptosis1.18189905
77MP0002332_abnormal_exercise_endurance1.17871749
78MP0003787_abnormal_imprinting1.17573604
79MP0003121_genomic_imprinting1.16508599
80MP0002938_white_spotting1.16105051
81MP0002909_abnormal_adrenal_gland1.15902838
82MP0004484_altered_response_of1.14278337
83MP0000372_irregular_coat_pigmentation1.12948636
84MP0005332_abnormal_amino_acid1.12697816
85MP0004233_abnormal_muscle_weight1.12413237
86MP0002078_abnormal_glucose_homeostasis1.10921212
87MP0002693_abnormal_pancreas_physiology1.10801323
88MP0003656_abnormal_erythrocyte_physiolo1.09414111
89MP0002882_abnormal_neuron_morphology1.08847354
90MP0002066_abnormal_motor_capabilities/c1.07666937
91MP0001986_abnormal_taste_sensitivity1.05195282
92MP0002127_abnormal_cardiovascular_syste1.01818354
93MP0000747_muscle_weakness0.98342054
94MP0005174_abnormal_tail_pigmentation0.98025057
95MP0010329_abnormal_lipoprotein_level0.97548950
96MP0001485_abnormal_pinna_reflex0.97495397
97MP0006138_congestive_heart_failure0.97461642
98MP0003186_abnormal_redox_activity0.97390621
99MP0000013_abnormal_adipose_tissue0.96559977
100MP0000427_abnormal_hair_cycle0.95435867
101MP0005620_abnormal_muscle_contractility0.94164033
102MP0009697_abnormal_copulation0.92549905
103MP0002152_abnormal_brain_morphology0.91869093
104MP0002752_abnormal_somatic_nervous0.91571443
105MP0002972_abnormal_cardiac_muscle0.91379785
106MP0000015_abnormal_ear_pigmentation0.91195742
107MP0008877_abnormal_DNA_methylation0.90480957
108MP0001764_abnormal_homeostasis0.89176513
109MP0005448_abnormal_energy_balance0.88720762
110MP0002102_abnormal_ear_morphology0.88446614
111MP0002928_abnormal_bile_duct0.86703535
112MP0005535_abnormal_body_temperature0.86133007
113MP0005551_abnormal_eye_electrophysiolog0.84828308
114MP0003136_yellow_coat_color0.83974372
115MP0003937_abnormal_limbs/digits/tail_de0.83813813
116MP0001756_abnormal_urination0.83490834
117MP0008775_abnormal_heart_ventricle0.83057171
118MP0004019_abnormal_vitamin_homeostasis0.81642839
119MP0003879_abnormal_hair_cell0.80446576
120MP0003953_abnormal_hormone_level0.79251922
121MP0005195_abnormal_posterior_eye0.79197761
122MP0002106_abnormal_muscle_physiology0.78845860
123MP0005330_cardiomyopathy0.75411417
124MP0003315_abnormal_perineum_morphology0.75125324
125MP0000537_abnormal_urethra_morphology0.74555595
126MP0005369_muscle_phenotype0.73658395
127MP0004742_abnormal_vestibular_system0.73452260
128MP0002160_abnormal_reproductive_system0.73360566
129MP0001664_abnormal_digestion0.72583484
130MP0002229_neurodegeneration0.72218228
131MP0004133_heterotaxia0.70536424
132MP0008872_abnormal_physiological_respon0.69794251
133MP0002269_muscular_atrophy0.68926156
134MP0003123_paternal_imprinting0.68713872
135MP0000759_abnormal_skeletal_muscle0.66984051
136MP0002069_abnormal_eating/drinking_beha0.66876132
137MP0001299_abnormal_eye_distance/0.66363936
138MP0002233_abnormal_nose_morphology0.64975282
139MP0005084_abnormal_gallbladder_morpholo0.63649166

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.80171653
2Abnormal mitochondria in muscle tissue (HP:0008316)5.51994627
3Progressive macrocephaly (HP:0004481)4.91393499
4Mitochondrial inheritance (HP:0001427)4.83119153
5Acute encephalopathy (HP:0006846)4.54039447
6Neuroendocrine neoplasm (HP:0100634)4.44707922
7Pheochromocytoma (HP:0002666)4.34106778
8Increased CSF lactate (HP:0002490)4.22741748
9Increased serum pyruvate (HP:0003542)4.09858161
10Abnormality of glycolysis (HP:0004366)4.09858161
11Hepatocellular necrosis (HP:0001404)3.92129347
12Hypothermia (HP:0002045)3.78317892
13Focal motor seizures (HP:0011153)3.73143312
14Global brain atrophy (HP:0002283)3.54025335
15Hypobetalipoproteinemia (HP:0003563)3.48188914
16Pancreatic fibrosis (HP:0100732)3.47369285
17Methylmalonic acidemia (HP:0002912)3.44734719
18Intestinal atresia (HP:0011100)3.43135110
19Hepatic necrosis (HP:0002605)3.39172264
20Hyperglycinemia (HP:0002154)3.39168943
21Tubulointerstitial nephritis (HP:0001970)3.36373710
22Calf muscle hypertrophy (HP:0008981)3.36321174
23Muscle hypertrophy of the lower extremities (HP:0008968)3.31957594
24Febrile seizures (HP:0002373)3.28579539
25Exercise intolerance (HP:0003546)3.23135774
26Pancreatic cysts (HP:0001737)3.22210248
27Increased hepatocellular lipid droplets (HP:0006565)3.11641035
28Cerebral edema (HP:0002181)3.07171464
29Atonic seizures (HP:0010819)3.05900340
30Central scotoma (HP:0000603)3.05362319
31Limb dystonia (HP:0002451)3.00731444
32Akinesia (HP:0002304)3.00450036
33Ketoacidosis (HP:0001993)2.97084931
34Optic disc pallor (HP:0000543)2.94734056
35Epileptic encephalopathy (HP:0200134)2.90412710
36Dyskinesia (HP:0100660)2.90166048
37Lipid accumulation in hepatocytes (HP:0006561)2.88668330
38Abnormality of vitamin B metabolism (HP:0004340)2.88465087
39Myokymia (HP:0002411)2.84949170
40Abnormality of midbrain morphology (HP:0002418)2.79598185
41Molar tooth sign on MRI (HP:0002419)2.79598185
42Poor suck (HP:0002033)2.78500946
43Lactic acidosis (HP:0003128)2.78369351
44Leukodystrophy (HP:0002415)2.78188972
45Focal seizures (HP:0007359)2.77356670
46Abnormality of alanine metabolism (HP:0010916)2.75616643
47Hyperalaninemia (HP:0003348)2.75616643
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75616643
49True hermaphroditism (HP:0010459)2.75295597
50Hyperventilation (HP:0002883)2.72284100
51Diminished movement (HP:0002374)2.72167820
52Progressive inability to walk (HP:0002505)2.70836105
53Respiratory failure (HP:0002878)2.70678273
54Glycosuria (HP:0003076)2.63468404
55Abnormality of urine glucose concentration (HP:0011016)2.63468404
56Nephronophthisis (HP:0000090)2.63282633
57Abnormal hair whorl (HP:0010721)2.61530373
58Renal Fanconi syndrome (HP:0001994)2.60663875
59Medial flaring of the eyebrow (HP:0010747)2.60658904
60Double outlet right ventricle (HP:0001719)2.58126494
61Congenital malformation of the right heart (HP:0011723)2.58126494
62Gait imbalance (HP:0002141)2.55156311
63Prolonged QT interval (HP:0001657)2.54895226
64Poor coordination (HP:0002370)2.50107949
65Increased intramyocellular lipid droplets (HP:0012240)2.42001402
66Agitation (HP:0000713)2.40842515
67Exercise-induced muscle cramps (HP:0003710)2.40816840
68Increased serum lactate (HP:0002151)2.37546365
69Methylmalonic aciduria (HP:0012120)2.36686191
70Congenital primary aphakia (HP:0007707)2.35953524
71Aplasia/hypoplasia of the uterus (HP:0008684)2.34337068
72Abnormality of the renal medulla (HP:0100957)2.34049658
73Neoplasm of the peripheral nervous system (HP:0100007)2.33812016
74Type II lissencephaly (HP:0007260)2.32512306
75Abnormality of macular pigmentation (HP:0008002)2.31729245
76Acanthocytosis (HP:0001927)2.31643005
77Abnormality of the vitamin B12 metabolism (HP:0004341)2.30653866
78Respiratory difficulties (HP:0002880)2.30224172
79Decreased muscle mass (HP:0003199)2.29871015
80Severe visual impairment (HP:0001141)2.29850366
81Abnormality of the renal cortex (HP:0011035)2.29574638
82Postural tremor (HP:0002174)2.28605778
83Polyphagia (HP:0002591)2.28324595
84Nephrogenic diabetes insipidus (HP:0009806)2.27730683
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23571204
86Absence seizures (HP:0002121)2.23357902
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20858762
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20858762
89Exercise-induced myalgia (HP:0003738)2.20759554
90Retinal dysplasia (HP:0007973)2.18738191
91Abnormality of the vocal cords (HP:0008777)2.18579686
92Shoulder girdle muscle weakness (HP:0003547)2.18056631
93Abnormality of the calf musculature (HP:0001430)2.17341965
94Rimmed vacuoles (HP:0003805)2.17322123
95Abnormality of glycine metabolism (HP:0010895)2.16562847
96Abnormality of serine family amino acid metabolism (HP:0010894)2.16562847
97Hypoglycemic coma (HP:0001325)2.16067411
98X-linked dominant inheritance (HP:0001423)2.14136428
99Broad-based gait (HP:0002136)2.12853448
100Polydipsia (HP:0001959)2.12154130
101Abnormal drinking behavior (HP:0030082)2.12154130
102Renal cortical cysts (HP:0000803)2.11840525
103Emotional lability (HP:0000712)2.11139066
104Amblyopia (HP:0000646)2.09923133
105Anxiety (HP:0000739)2.09299459
106Abnormality of vitamin metabolism (HP:0100508)2.09293622
107Fetal akinesia sequence (HP:0001989)2.09172582
108Hyperinsulinemic hypoglycemia (HP:0000825)2.06663287
109Palpitations (HP:0001962)2.06031896
110Hemiparesis (HP:0001269)2.05249248
111Gaze-evoked nystagmus (HP:0000640)2.05074221
112Ketosis (HP:0001946)2.04891408
113Visual hallucinations (HP:0002367)2.04802635
114Oligomenorrhea (HP:0000876)2.04314025
115Increased muscle lipid content (HP:0009058)2.01366270
116Inability to walk (HP:0002540)2.00594920
117Dialeptic seizures (HP:0011146)2.00231016
118Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98410016
119Tubular atrophy (HP:0000092)1.97813460
120Tubulointerstitial abnormality (HP:0001969)1.97254577
121Abnormality of the hip-girdle musculature (HP:0001445)1.96440599
122Abnormality of the musculature of the pelvis (HP:0001469)1.96440599
123Hyperglycemia (HP:0003074)1.96434623
124Delayed gross motor development (HP:0002194)1.95369081
125Genital tract atresia (HP:0001827)1.95351867
126Atrial fibrillation (HP:0005110)1.95071368
127Aplasia/Hypoplasia of the lens (HP:0008063)1.94736226
128Cystic liver disease (HP:0006706)1.94692882
129Failure to thrive in infancy (HP:0001531)1.94414406
130Primary atrial arrhythmia (HP:0001692)1.93920951
131Hypoplasia of the uterus (HP:0000013)1.93130037
132Left ventricular hypertrophy (HP:0001712)1.92193093
133Hypoglycemic seizures (HP:0002173)1.91883486
134Generalized tonic-clonic seizures (HP:0002069)1.91806350
135Cerebral hemorrhage (HP:0001342)1.91494241
136Supraventricular tachycardia (HP:0004755)1.90102378
137Delayed CNS myelination (HP:0002188)1.89394554
138Progressive cerebellar ataxia (HP:0002073)1.88466240
139Sudden death (HP:0001699)1.88353904
140Hypoventilation (HP:0002791)1.88350688
141Abnormality of renal resorption (HP:0011038)1.88167352
142Gastrointestinal atresia (HP:0002589)1.87575983
143Vaginal atresia (HP:0000148)1.87189516
144Pelvic girdle muscle weakness (HP:0003749)1.86499393
1453-Methylglutaconic aciduria (HP:0003535)1.85733491
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85316414
147Postaxial foot polydactyly (HP:0001830)1.83935853
148Metaphyseal dysplasia (HP:0100255)1.83911326
149Dysdiadochokinesis (HP:0002075)1.83608204
150Specific learning disability (HP:0001328)1.83141975
151Hypolipoproteinemia (HP:0010981)1.82271459
152Postaxial hand polydactyly (HP:0001162)1.80978651
153Supraventricular arrhythmia (HP:0005115)1.80464455
154Myoglobinuria (HP:0002913)1.79828174
155Abnormality of serum amino acid levels (HP:0003112)1.78928185
156Tachypnea (HP:0002789)1.78927244
157Impaired vibration sensation in the lower limbs (HP:0002166)1.77796554
158Truncal ataxia (HP:0002078)1.77592583
159CNS demyelination (HP:0007305)1.77507558
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.76817116
161Morphological abnormality of the pyramidal tract (HP:0002062)1.74597672
162Brushfield spots (HP:0001088)1.73818353
163Abnormal pancreas size (HP:0012094)1.72577351
164Progressive external ophthalmoplegia (HP:0000590)1.72571781
165Proximal tubulopathy (HP:0000114)1.72383438
166Myotonia (HP:0002486)1.72105931
167Congenital stationary night blindness (HP:0007642)1.71104340
168Abnormal EKG (HP:0003115)1.70951418
169Ragged-red muscle fibers (HP:0003200)1.70293088
170Hyperglycinuria (HP:0003108)1.69294017
171Aplasia/Hypoplasia of the tibia (HP:0005772)1.68340336
172Oculomotor apraxia (HP:0000657)1.68327783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.95723887
2FRK3.92970447
3MAP4K23.71348305
4CASK3.66965651
5STK162.91405061
6ARAF2.84372203
7MAP3K42.81710225
8MAP2K72.75462141
9MAPK132.71981586
10STK38L2.70429138
11NEK12.47052708
12CDK192.45250850
13MAP3K122.42937966
14NTRK32.12554948
15MINK12.10467336
16NME11.99295242
17MAPKAPK31.84356238
18MARK11.83899807
19MAP3K91.82756994
20TNIK1.81219053
21EPHA41.70339500
22PNCK1.67814431
23PRKD31.67465473
24MYLK1.64848000
25TSSK61.62364745
26PDK31.56816154
27PDK41.56816154
28OBSCN1.56426162
29GRK11.55683102
30PLK21.54773254
31BUB11.51554247
32ACVR1B1.50042128
33EEF2K1.49218047
34DAPK11.47776782
35AKT31.44747636
36MAP2K41.39378994
37WNK41.31072856
38LIMK11.26665011
39SIK31.26069494
40STK381.24492153
41CDK81.24404407
42CAMKK21.20565372
43DAPK21.19448643
44TGFBR11.18624906
45MAPKAPK51.17686887
46MAP2K61.15794815
47CSNK1G21.10578711
48UHMK11.10527327
49PHKG11.08698100
50PHKG21.08698100
51CSNK1G31.07342106
52BMPR1B1.05315104
53FGFR21.02875299
54CAMK2B1.02807564
55BRAF1.01694803
56CAMK1G1.01634542
57OXSR10.99062110
58PRPF4B0.98948831
59CAMK2A0.98031778
60KSR10.97369314
61ZAK0.95379624
62SRPK10.92906967
63IRAK10.91753512
64BRSK20.91538206
65BCKDK0.90554055
66ERBB30.88444819
67ADRBK20.82802139
68PRKCG0.82047952
69BCR0.81784386
70PINK10.81766713
71GRK50.80467678
72CDK50.78953796
73EPHA30.77149495
74NUAK10.75802900
75PKN10.75418246
76CAMK10.74566393
77BMPR20.74132366
78MUSK0.74097983
79NEK20.73801167
80RAF10.70778660
81PAK30.69328426
82AKT20.68945035
83CDK180.68797911
84CDK140.67529198
85CAMK2D0.66814619
86PRKAA10.65921487
87NTRK20.65495437
88SGK4940.64837270
89SGK2230.64837270
90TNK20.64602984
91PIK3CA0.63656968
92PRKAA20.62346249
93CDK11A0.61667547
94DYRK1A0.60879806
95RPS6KB10.59984653
96CSNK1A10.58553811
97CDK150.58109578
98ADRBK10.57940046
99CSNK1A1L0.57523506
100CSNK1G10.57325805
101RPS6KA40.57078064
102PRKCI0.57037138
103PRKCH0.55123436
104GRK70.54758110
105DYRK30.53533462
106WNK30.51890285
107MAP2K10.51859956
108SGK20.50768767
109IRAK20.50369138
110MARK20.49624504
111PRKCE0.48680172
112CDK30.47852588
113VRK10.47011174
114DYRK20.46726730
115GRK60.46054227
116ROCK10.44948223
117BRD40.44460872
118ROCK20.44442730
119WNK10.44017140
120MKNK10.42922785
121CAMK2G0.42882162
122EIF2AK30.42630850
123MST40.42627967
124NLK0.42287765
125MAP3K130.42201264
126PIK3CG0.42023078
127PRKACA0.41890974
128MAPK120.40914346
129MKNK20.40788908
130PTK2B0.39164436
131INSRR0.39019645
132FER0.38839712
133CSNK1D0.38794902
134PDK20.38677652
135STK30.37909421
136RPS6KA50.37574163
137TRPM70.37500820
138STK390.36299962
139PLK30.34667781

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.58218752
2Parkinsons disease_Homo sapiens_hsa050124.33622580
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.98269161
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.42097301
5Alzheimers disease_Homo sapiens_hsa050103.22612583
6Cardiac muscle contraction_Homo sapiens_hsa042602.92997723
7Huntingtons disease_Homo sapiens_hsa050162.92361497
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.69991326
9Nicotine addiction_Homo sapiens_hsa050332.62138757
10Synaptic vesicle cycle_Homo sapiens_hsa047212.53961996
11Olfactory transduction_Homo sapiens_hsa047402.51372667
12Sulfur metabolism_Homo sapiens_hsa009202.24840783
13Collecting duct acid secretion_Homo sapiens_hsa049662.17855468
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14782190
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12228964
16GABAergic synapse_Homo sapiens_hsa047271.95105610
17Circadian entrainment_Homo sapiens_hsa047131.90065348
18Morphine addiction_Homo sapiens_hsa050321.89031074
19Dopaminergic synapse_Homo sapiens_hsa047281.88189756
20Proteasome_Homo sapiens_hsa030501.86198666
21Amphetamine addiction_Homo sapiens_hsa050311.81987971
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65029362
23Serotonergic synapse_Homo sapiens_hsa047261.58388642
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56811848
25Pyruvate metabolism_Homo sapiens_hsa006201.52721867
26Vibrio cholerae infection_Homo sapiens_hsa051101.51341961
27Linoleic acid metabolism_Homo sapiens_hsa005911.50846709
28Steroid biosynthesis_Homo sapiens_hsa001001.50419914
29Long-term potentiation_Homo sapiens_hsa047201.46831591
30Glutamatergic synapse_Homo sapiens_hsa047241.43843535
31Tryptophan metabolism_Homo sapiens_hsa003801.41230159
32Taste transduction_Homo sapiens_hsa047421.40069333
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38422975
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34766684
35Phototransduction_Homo sapiens_hsa047441.34286528
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.33161525
37Propanoate metabolism_Homo sapiens_hsa006401.30306834
38Cholinergic synapse_Homo sapiens_hsa047251.29662214
39beta-Alanine metabolism_Homo sapiens_hsa004101.26471262
40Ether lipid metabolism_Homo sapiens_hsa005651.25506517
41Renin secretion_Homo sapiens_hsa049241.24831145
42Selenocompound metabolism_Homo sapiens_hsa004501.21689156
43Circadian rhythm_Homo sapiens_hsa047101.19131272
44Calcium signaling pathway_Homo sapiens_hsa040201.18825090
45Insulin secretion_Homo sapiens_hsa049111.16382532
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15432013
47Peroxisome_Homo sapiens_hsa041461.13379212
48Fatty acid metabolism_Homo sapiens_hsa012121.12810954
49Salivary secretion_Homo sapiens_hsa049701.12542452
50Cocaine addiction_Homo sapiens_hsa050301.12400478
51Protein export_Homo sapiens_hsa030601.12182954
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11151001
53Nitrogen metabolism_Homo sapiens_hsa009101.10910781
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09587508
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09571048
56Long-term depression_Homo sapiens_hsa047301.08254407
57Ribosome_Homo sapiens_hsa030101.07170900
58Oxytocin signaling pathway_Homo sapiens_hsa049211.06616881
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04172594
60RNA polymerase_Homo sapiens_hsa030201.00965695
61Fatty acid degradation_Homo sapiens_hsa000710.99844356
62ABC transporters_Homo sapiens_hsa020100.96507521
63Gap junction_Homo sapiens_hsa045400.95800003
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93666503
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93512278
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93108814
67Dilated cardiomyopathy_Homo sapiens_hsa054140.92925029
68Butanoate metabolism_Homo sapiens_hsa006500.92218721
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91184885
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89705226
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89337335
72Carbon metabolism_Homo sapiens_hsa012000.88538862
73Gastric acid secretion_Homo sapiens_hsa049710.88435210
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88364146
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87662984
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83705485
77Alcoholism_Homo sapiens_hsa050340.82578055
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81427645
79Retinol metabolism_Homo sapiens_hsa008300.80885369
80Arginine and proline metabolism_Homo sapiens_hsa003300.80411892
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78582260
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77166981
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76986784
84Purine metabolism_Homo sapiens_hsa002300.76832183
85Oocyte meiosis_Homo sapiens_hsa041140.75627193
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74543084
87Phenylalanine metabolism_Homo sapiens_hsa003600.74107528
88Fructose and mannose metabolism_Homo sapiens_hsa000510.73361984
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.73245600
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72298749
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67935519
92Chemical carcinogenesis_Homo sapiens_hsa052040.67916267
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66836442
94Lysine degradation_Homo sapiens_hsa003100.65839917
95Glucagon signaling pathway_Homo sapiens_hsa049220.64002824
96Fat digestion and absorption_Homo sapiens_hsa049750.59930192
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.57352818
98Histidine metabolism_Homo sapiens_hsa003400.53316575
99cAMP signaling pathway_Homo sapiens_hsa040240.52587534
100Vitamin B6 metabolism_Homo sapiens_hsa007500.52536882
101Ovarian steroidogenesis_Homo sapiens_hsa049130.52012058
102GnRH signaling pathway_Homo sapiens_hsa049120.50852087
103Caffeine metabolism_Homo sapiens_hsa002320.49424994
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48267274
105Fanconi anemia pathway_Homo sapiens_hsa034600.47861694
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47788834
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47713775
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47185072
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46688212
110Tyrosine metabolism_Homo sapiens_hsa003500.45359518
111Sphingolipid metabolism_Homo sapiens_hsa006000.44933116
112Melanogenesis_Homo sapiens_hsa049160.44819774
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.44036220
114Spliceosome_Homo sapiens_hsa030400.43950475
115Fatty acid elongation_Homo sapiens_hsa000620.43941925
116Axon guidance_Homo sapiens_hsa043600.43482336
117Pyrimidine metabolism_Homo sapiens_hsa002400.43413239
118Type II diabetes mellitus_Homo sapiens_hsa049300.43403665
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43217833
120Sulfur relay system_Homo sapiens_hsa041220.42506732
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39146007
122Regulation of autophagy_Homo sapiens_hsa041400.39073744
123Non-homologous end-joining_Homo sapiens_hsa034500.38384019
124Thyroid hormone synthesis_Homo sapiens_hsa049180.37659367
125Metabolic pathways_Homo sapiens_hsa011000.37151554
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34888467
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.33921917
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33131861
129Folate biosynthesis_Homo sapiens_hsa007900.32847147
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32140693
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31103388
132mRNA surveillance pathway_Homo sapiens_hsa030150.30368671
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28472933
134RNA degradation_Homo sapiens_hsa030180.28028610
135Insulin signaling pathway_Homo sapiens_hsa049100.25875770
136ErbB signaling pathway_Homo sapiens_hsa040120.25078253
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24881120
138Basal transcription factors_Homo sapiens_hsa030220.24579406
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22853252
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22836237
141Phagosome_Homo sapiens_hsa041450.19393959
142RNA transport_Homo sapiens_hsa030130.19363229
143Estrogen signaling pathway_Homo sapiens_hsa049150.18825531
144Colorectal cancer_Homo sapiens_hsa052100.17978373
145Biosynthesis of amino acids_Homo sapiens_hsa012300.17812848
146Nucleotide excision repair_Homo sapiens_hsa034200.17706722

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