MTERF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)4.79726599
2negative regulation of DNA-dependent DNA replication (GO:2000104)4.66943170
3keratinocyte development (GO:0003334)4.19409313
4mitotic metaphase plate congression (GO:0007080)4.14549841
5centriole assembly (GO:0098534)4.07368828
6regulation of nuclear cell cycle DNA replication (GO:0033262)4.06856120
7cullin deneddylation (GO:0010388)4.05031743
8establishment of integrated proviral latency (GO:0075713)4.04777273
9DNA strand elongation involved in DNA replication (GO:0006271)4.02452532
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.01900523
11protein localization to kinetochore (GO:0034501)3.97080508
12histone exchange (GO:0043486)3.95006472
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.93487255
14regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.93070355
15telomere maintenance via semi-conservative replication (GO:0032201)3.92499373
16DNA double-strand break processing (GO:0000729)3.92355147
17DNA replication checkpoint (GO:0000076)3.89452087
18ribosome assembly (GO:0042255)3.87492761
19anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.86853830
20rRNA modification (GO:0000154)3.84422812
21DNA strand elongation (GO:0022616)3.83007105
22adenosine metabolic process (GO:0046085)3.82921918
23DNA replication-independent nucleosome organization (GO:0034724)3.82596801
24DNA replication-independent nucleosome assembly (GO:0006336)3.82596801
25DNA integration (GO:0015074)3.79707552
26superoxide anion generation (GO:0042554)3.78942514
27metaphase plate congression (GO:0051310)3.77131296
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76830954
29kinetochore assembly (GO:0051382)3.74532581
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.74049734
31maturation of 5.8S rRNA (GO:0000460)3.72994681
32rRNA methylation (GO:0031167)3.70099746
33RNA destabilization (GO:0050779)3.67092328
34protein deneddylation (GO:0000338)3.65077242
35tRNA methylation (GO:0030488)3.63050979
36negative regulation of ligase activity (GO:0051352)3.58285326
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.58285326
38replicative senescence (GO:0090399)3.57043312
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.56010834
40DNA strand renaturation (GO:0000733)3.55224972
41telomere maintenance via recombination (GO:0000722)3.53099364
42centriole replication (GO:0007099)3.50562156
43mitotic recombination (GO:0006312)3.48987678
44histone mRNA metabolic process (GO:0008334)3.48428650
45DNA replication-dependent nucleosome assembly (GO:0006335)3.47317970
46DNA replication-dependent nucleosome organization (GO:0034723)3.47317970
47nucleotide transmembrane transport (GO:1901679)3.45657914
48oxidative phosphorylation (GO:0006119)3.44592660
49G-protein coupled receptor internalization (GO:0002031)3.39912604
50respiratory chain complex IV assembly (GO:0008535)3.37780820
51regulation of timing of cell differentiation (GO:0048505)3.37132786
52deoxyribonucleotide biosynthetic process (GO:0009263)3.37124932
53protein localization to chromosome, centromeric region (GO:0071459)3.36079718
54androgen biosynthetic process (GO:0006702)3.35976891
55establishment of viral latency (GO:0019043)3.34493614
56purine nucleobase biosynthetic process (GO:0009113)3.34246621
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33846259
58spliceosomal snRNP assembly (GO:0000387)3.33269352
59negative regulation of keratinocyte proliferation (GO:0010839)3.31376583
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29054098
61somatic hypermutation of immunoglobulin genes (GO:0016446)3.28962333
62somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28962333
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28030527
64ATP synthesis coupled proton transport (GO:0015986)3.28030527
65regulation of cellular amino acid metabolic process (GO:0006521)3.27841176
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.27828773
67regulation of mitotic spindle checkpoint (GO:1903504)3.27828773
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27283491
69preassembly of GPI anchor in ER membrane (GO:0016254)3.24954956
70kinetochore organization (GO:0051383)3.24776701
71oligosaccharide catabolic process (GO:0009313)3.24450828
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24017440
73postreplication repair (GO:0006301)3.22997575
74regulation of mitochondrial translation (GO:0070129)3.22661149
75regulation of meiosis I (GO:0060631)3.22259639
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20607799
77replication fork processing (GO:0031297)3.19316930
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18773550
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18773550
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18773550
81limb bud formation (GO:0060174)3.18152055
82attachment of spindle microtubules to kinetochore (GO:0008608)3.16636874
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16446405
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16446405
85protein K6-linked ubiquitination (GO:0085020)3.16096027
86RNA methylation (GO:0001510)3.15904410
87response to folic acid (GO:0051593)3.15042749
88positive regulation of ligase activity (GO:0051351)3.12357079
89spindle checkpoint (GO:0031577)3.11781397
90protein targeting to mitochondrion (GO:0006626)3.11399749
91GPI anchor biosynthetic process (GO:0006506)3.11385026
92telomere maintenance via telomere lengthening (GO:0010833)3.10086141
93chaperone-mediated protein transport (GO:0072321)3.09426772
94ceramide catabolic process (GO:0046514)3.08584105
95signal transduction involved in DNA damage checkpoint (GO:0072422)3.08071880
96signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08071880
97deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.07735619
98microtubule depolymerization (GO:0007019)3.07247142
99nucleobase biosynthetic process (GO:0046112)3.07050873
100signal transduction involved in cell cycle checkpoint (GO:0072395)3.06691046
101regulation of development, heterochronic (GO:0040034)3.06058015
102pseudouridine synthesis (GO:0001522)3.05587963
103mitochondrial respiratory chain complex assembly (GO:0033108)3.04676662
104protein localization to mitochondrion (GO:0070585)3.04658360
105response to X-ray (GO:0010165)3.04637263
106mitotic spindle checkpoint (GO:0071174)3.04035731
107histone H2B ubiquitination (GO:0033523)3.03741029
108mitotic sister chromatid segregation (GO:0000070)3.02827331
109negative regulation of mitotic sister chromatid separation (GO:2000816)3.02807648
110negative regulation of sister chromatid segregation (GO:0033046)3.02807648
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02807648
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02807648
113negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02807648
114amino sugar catabolic process (GO:0046348)3.02765444
115female gonad development (GO:0008585)3.01600480
116non-recombinational repair (GO:0000726)2.99823039
117double-strand break repair via nonhomologous end joining (GO:0006303)2.99823039
118establishment of chromosome localization (GO:0051303)2.99259045
119positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.99082307
120regulation of ubiquitin-protein transferase activity (GO:0051438)2.98409480
121negative regulation of chromosome segregation (GO:0051985)2.96614939
122synapsis (GO:0007129)2.95449259
123transcription-coupled nucleotide-excision repair (GO:0006283)2.95331957
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94428486
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94428486
126GPI anchor metabolic process (GO:0006505)2.94343352
127positive regulation of protein homodimerization activity (GO:0090073)2.94268803
128cilium or flagellum-dependent cell motility (GO:0001539)2.91858096
129regulation of NIK/NF-kappaB signaling (GO:1901222)2.91031709
130tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88818061
131RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88818061
132DNA ligation (GO:0006266)2.87034060
133glycosphingolipid catabolic process (GO:0046479)2.84202870
134transcription elongation from RNA polymerase I promoter (GO:0006362)2.80713713
135termination of RNA polymerase I transcription (GO:0006363)2.79829093
136DNA damage response, detection of DNA damage (GO:0042769)2.79159122
137deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.77522497
138protein-cofactor linkage (GO:0018065)2.76271279
139regulation of double-strand break repair via homologous recombination (GO:0010569)2.73642549
140germinal center formation (GO:0002467)2.73053870
141cell proliferation in forebrain (GO:0021846)2.71866674
142NAD biosynthetic process (GO:0009435)2.70433185
143mesenchymal cell differentiation involved in kidney development (GO:0072161)2.69791120
144mesenchymal cell differentiation involved in renal system development (GO:2001012)2.69791120
145regulation of activation of Janus kinase activity (GO:0010533)2.69352385
146tRNA modification (GO:0006400)2.66593198
147deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.64635463
148single strand break repair (GO:0000012)2.64615743
149DNA synthesis involved in DNA repair (GO:0000731)2.64133770
150amine catabolic process (GO:0009310)2.62584143
151cellular biogenic amine catabolic process (GO:0042402)2.62584143
152transcription elongation from RNA polymerase III promoter (GO:0006385)2.61666771
153termination of RNA polymerase III transcription (GO:0006386)2.61666771
154lymphoid progenitor cell differentiation (GO:0002320)2.60528331
155protein heterotetramerization (GO:0051290)2.59952547
156left/right axis specification (GO:0070986)2.58164117
157negative regulation of myoblast differentiation (GO:0045662)2.56539500
158activation of NF-kappaB-inducing kinase activity (GO:0007250)2.56355180
159proteasome assembly (GO:0043248)2.54923328
160response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.53938990
161glucocorticoid biosynthetic process (GO:0006704)2.53746527
162DNA catabolic process, exonucleolytic (GO:0000738)2.52260804
163DNA methylation involved in gamete generation (GO:0043046)2.49562641
164polyol transport (GO:0015791)2.48975790
165glycolipid catabolic process (GO:0019377)2.48622745
166extracellular negative regulation of signal transduction (GO:1900116)2.48433869
167extracellular regulation of signal transduction (GO:1900115)2.48433869
168detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.48427621
169developmental pigmentation (GO:0048066)2.48284923
170androgen metabolic process (GO:0008209)2.47119882
171regulation of centriole replication (GO:0046599)2.46985010
172positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.45333870
173DNA-dependent DNA replication (GO:0006261)2.44690981
174regulation of histone H3-K27 methylation (GO:0061085)2.40378388
175reciprocal DNA recombination (GO:0035825)2.38606144
176reciprocal meiotic recombination (GO:0007131)2.38606144
177meiotic chromosome segregation (GO:0045132)2.37495321
178regulation of helicase activity (GO:0051095)2.37318596
179adenine nucleotide transport (GO:0051503)2.36951763
180mitochondrial DNA replication (GO:0006264)2.36792903
181CENP-A containing nucleosome assembly (GO:0034080)2.35448592
182regulation of DNA endoreduplication (GO:0032875)2.35348626
183tryptophan catabolic process (GO:0006569)2.34656793
184indole-containing compound catabolic process (GO:0042436)2.34656793
185indolalkylamine catabolic process (GO:0046218)2.34656793
186otic vesicle formation (GO:0030916)2.33560920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.24206881
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.77156903
3PCGF2_27294783_Chip-Seq_ESCs_Mouse3.36844436
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.32277034
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.20580518
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.16494986
7GBX2_23144817_ChIP-Seq_PC3_Human3.00934397
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98493652
9PCGF2_27294783_Chip-Seq_NPCs_Mouse2.96126452
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.94580903
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.90765838
12NFE2_27457419_Chip-Seq_LIVER_Mouse2.89909300
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81350663
14ELK1_19687146_ChIP-ChIP_HELA_Human2.78716350
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78228666
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69558611
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.69312932
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66555214
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64054169
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.62362240
21VDR_23849224_ChIP-Seq_CD4+_Human2.56193273
22EZH2_27294783_Chip-Seq_NPCs_Mouse2.42511212
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39393049
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.38608530
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35839679
26FOXP3_21729870_ChIP-Seq_TREG_Human2.31355272
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28031121
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26915345
29DCP1A_22483619_ChIP-Seq_HELA_Human2.26396971
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23291078
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.19092278
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18858843
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18577745
34TP63_19390658_ChIP-ChIP_HaCaT_Human2.16624775
35EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.11592961
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10163724
37POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09152164
38EGR1_23403033_ChIP-Seq_LIVER_Mouse2.08437120
39NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07544464
40STAT3_18555785_Chip-Seq_ESCs_Mouse2.06270192
41SUZ12_18555785_Chip-Seq_ESCs_Mouse2.04672295
42EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse2.02335366
43PADI4_21655091_ChIP-ChIP_MCF-7_Human2.02157622
44E2F1_18555785_Chip-Seq_ESCs_Mouse2.01998009
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.99016298
46NMYC_18555785_Chip-Seq_ESCs_Mouse1.98816736
47P53_22387025_ChIP-Seq_ESCs_Mouse1.98539030
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95398988
49RUNX1_27457419_Chip-Seq_LIVER_Mouse1.93489295
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.93385227
51P300_18555785_Chip-Seq_ESCs_Mouse1.93078224
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93063767
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93048449
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.92844557
55GABP_19822575_ChIP-Seq_HepG2_Human1.88779396
56AR_21909140_ChIP-Seq_LNCAP_Human1.88013060
57E2F7_22180533_ChIP-Seq_HELA_Human1.87339357
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86370083
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85928977
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.85689487
61TTF2_22483619_ChIP-Seq_HELA_Human1.83680523
62ZFX_18555785_Chip-Seq_ESCs_Mouse1.82367140
63TAF15_26573619_Chip-Seq_HEK293_Human1.81090172
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.79585268
65VDR_22108803_ChIP-Seq_LS180_Human1.78149207
66KLF4_18555785_Chip-Seq_ESCs_Mouse1.77992703
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.77708475
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.76926785
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.75947444
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.75120640
71ZNF274_21170338_ChIP-Seq_K562_Hela1.75109612
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.74925833
73SMAD1_18555785_Chip-Seq_ESCs_Mouse1.72891427
74PU1_27457419_Chip-Seq_LIVER_Mouse1.71551935
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.71417175
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71047782
77ESRRB_18555785_Chip-Seq_ESCs_Mouse1.70768207
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70603394
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70218501
80FUS_26573619_Chip-Seq_HEK293_Human1.68161533
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67530468
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.67017687
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66402566
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61747433
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61022880
86CTCF_18555785_Chip-Seq_ESCs_Mouse1.60514157
87MYC_18940864_ChIP-ChIP_HL60_Human1.60474627
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60266058
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.59769235
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57711250
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57497985
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56587347
93P300_19829295_ChIP-Seq_ESCs_Human1.55739917
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55036076
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.54052833
96IRF1_19129219_ChIP-ChIP_H3396_Human1.50028644
97XRN2_22483619_ChIP-Seq_HELA_Human1.49459312
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48630957
99EWS_26573619_Chip-Seq_HEK293_Human1.47575606
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44644394
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.43972663
102KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43475265
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41084501
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.39379699
105SALL1_21062744_ChIP-ChIP_HESCs_Human1.38899673
106ER_23166858_ChIP-Seq_MCF-7_Human1.38763091
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38728611
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38230643
109RNF2_27304074_Chip-Seq_NSC_Mouse1.35621184
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.33800641
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31522983
112IGF1R_20145208_ChIP-Seq_DFB_Human1.30942445
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30146247
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.28769866
115ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28605527
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.27991022
117HTT_18923047_ChIP-ChIP_STHdh_Human1.27507736
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27200408
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25466650
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25466650
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23589073
122RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22090780
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21673819
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20567589
125KDM5A_27292631_Chip-Seq_BREAST_Human1.17279156
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16621342
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16273733
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.13140115
129ELK1_22589737_ChIP-Seq_MCF10A_Human1.12060838
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11274889
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11040604
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10276534
133NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10231967
134SMAD4_21799915_ChIP-Seq_A2780_Human1.09015884
135NANOG_16153702_ChIP-ChIP_HESCs_Human1.08888710
136PHF8_20622853_ChIP-Seq_HELA_Human1.07665596
137CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07052341
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06899509
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05148464
140ETV1_20927104_ChIP-Seq_GIST48_Human1.04400427
141EZH2_22144423_ChIP-Seq_EOC_Human1.04310178
142HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03235792
143GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02415852
144PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01985518
145NFYB_21822215_ChIP-Seq_K562_Human1.01177968
146STAT1_17558387_ChIP-Seq_HELA_Human1.00935278
147CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99447316
148RUNX2_22187159_ChIP-Seq_PCA_Human0.99147068
149SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99123358
150ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98940821
151RBPJ_21746931_ChIP-Seq_IB4_Human0.98339449
152SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98136559
153TCF4_23295773_ChIP-Seq_U87_Human0.98065358
154KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97369617
155E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95985986
156STAT3_23295773_ChIP-Seq_U87_Human0.95866116
157CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95785273
158BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95644551
159CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91047373
160ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90133029
161CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87831093
162SOX2_16153702_ChIP-ChIP_HESCs_Human0.84616922
163MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81504441
164CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79640369
165SOX17_20123909_ChIP-Seq_XEN_Mouse0.78992485
166RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78630354
167DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78339939
168ELF5_23300383_ChIP-Seq_T47D_Human0.77162337
169TP53_22573176_ChIP-Seq_HFKS_Human0.75910888
170EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73966503
171BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73519228
172GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72738525
173SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72286720
174FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.71161579
175GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70278916
176TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.69822930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.48122437
2MP0000566_synostosis3.99920214
3MP0006292_abnormal_olfactory_placode3.75093275
4MP0008058_abnormal_DNA_repair3.57309358
5MP0004957_abnormal_blastocyst_morpholog3.50006688
6MP0003136_yellow_coat_color3.44616047
7MP0004381_abnormal_hair_follicle3.00675988
8MP0008932_abnormal_embryonic_tissue2.86843785
9MP0001986_abnormal_taste_sensitivity2.78865925
10MP0002102_abnormal_ear_morphology2.75974889
11MP0002277_abnormal_respiratory_mucosa2.39464970
12MP0003941_abnormal_skin_development2.33441416
13MP0003718_maternal_effect2.32656685
14MP0005379_endocrine/exocrine_gland_phen2.28139424
15MP0005171_absent_coat_pigmentation2.26801578
16MP0000015_abnormal_ear_pigmentation2.24972650
17MP0005451_abnormal_body_composition2.20568612
18MP0001529_abnormal_vocalization2.20383516
19MP0009697_abnormal_copulation2.17934571
20MP0000569_abnormal_digit_pigmentation2.14893961
21MP0006036_abnormal_mitochondrial_physio2.12820484
22MP0008789_abnormal_olfactory_epithelium2.05280121
23MP0005174_abnormal_tail_pigmentation2.03653305
24MP0005409_darkened_coat_color2.02094780
25MP0006035_abnormal_mitochondrial_morpho2.00967367
26MP0004019_abnormal_vitamin_homeostasis1.97066388
27MP0003186_abnormal_redox_activity1.95353530
28MP0003787_abnormal_imprinting1.84795905
29MP0008260_abnormal_autophagy1.84287510
30MP0003195_calcinosis1.80269641
31MP0000383_abnormal_hair_follicle1.80222958
32MP0003890_abnormal_embryonic-extraembry1.71024793
33MP0003786_premature_aging1.69731557
34MP0002876_abnormal_thyroid_physiology1.69709912
35MP0003111_abnormal_nucleus_morphology1.69054726
36MP0003806_abnormal_nucleotide_metabolis1.67730860
37MP0001293_anophthalmia1.67257317
38MP0010030_abnormal_orbit_morphology1.58595327
39MP0010094_abnormal_chromosome_stability1.57536700
40MP0008995_early_reproductive_senescence1.55794203
41MP0003123_paternal_imprinting1.52180780
42MP0001929_abnormal_gametogenesis1.48931963
43MP0005646_abnormal_pituitary_gland1.47965261
44MP0005394_taste/olfaction_phenotype1.42629613
45MP0005499_abnormal_olfactory_system1.42629613
46MP0001730_embryonic_growth_arrest1.42502576
47MP0008877_abnormal_DNA_methylation1.41753281
48MP0003950_abnormal_plasma_membrane1.40699208
49MP0002837_dystrophic_cardiac_calcinosis1.38747927
50MP0003693_abnormal_embryo_hatching1.37696061
51MP0002095_abnormal_skin_pigmentation1.37004573
52MP0000026_abnormal_inner_ear1.36788899
53MP0002132_abnormal_respiratory_system1.33269829
54MP0009764_decreased_sensitivity_to1.32854865
55MP0002938_white_spotting1.31039967
56MP0002249_abnormal_larynx_morphology1.30300131
57MP0003567_abnormal_fetal_cardiomyocyte1.28368220
58MP0000358_abnormal_cell_content/1.25268713
59MP0000653_abnormal_sex_gland1.24311206
60MP0000350_abnormal_cell_proliferation1.23222297
61MP0010307_abnormal_tumor_latency1.22108230
62MP0010386_abnormal_urinary_bladder1.22053803
63MP0004215_abnormal_myocardial_fiber1.21849396
64MP0002233_abnormal_nose_morphology1.21724344
65MP0000613_abnormal_salivary_gland1.21650003
66MP0005423_abnormal_somatic_nervous1.20903496
67MP0001145_abnormal_male_reproductive1.20733741
68MP0002234_abnormal_pharynx_morphology1.20322824
69MP0000579_abnormal_nail_morphology1.19394583
70MP0005670_abnormal_white_adipose1.19264947
71MP0001697_abnormal_embryo_size1.15516887
72MP0005395_other_phenotype1.15008710
73MP0005075_abnormal_melanosome_morpholog1.14655751
74MP0003938_abnormal_ear_development1.14640295
75MP0000427_abnormal_hair_cycle1.13129370
76MP0002751_abnormal_autonomic_nervous1.12608862
77MP0000049_abnormal_middle_ear1.11934165
78MP0002638_abnormal_pupillary_reflex1.11634608
79MP0003724_increased_susceptibility_to1.10200281
80MP0004742_abnormal_vestibular_system1.10181917
81MP0001672_abnormal_embryogenesis/_devel1.09820480
82MP0005380_embryogenesis_phenotype1.09820480
83MP0002138_abnormal_hepatobiliary_system1.07143591
84MP0005085_abnormal_gallbladder_physiolo1.04440863
85MP0001963_abnormal_hearing_physiology1.02979832
86MP0003221_abnormal_cardiomyocyte_apopto1.02756567
87MP0001661_extended_life_span1.01769601
88MP0002396_abnormal_hematopoietic_system1.01044110
89MP0000762_abnormal_tongue_morphology1.00409894
90MP0008872_abnormal_physiological_respon0.97800804
91MP0001919_abnormal_reproductive_system0.97221382
92MP0000372_irregular_coat_pigmentation0.96607088
93MP0003937_abnormal_limbs/digits/tail_de0.95281118
94MP0002098_abnormal_vibrissa_morphology0.95103455
95MP0000313_abnormal_cell_death0.94492556
96MP0005389_reproductive_system_phenotype0.93707425
97MP0008057_abnormal_DNA_replication0.93589180
98MP0005647_abnormal_sex_gland0.93222510
99MP0001727_abnormal_embryo_implantation0.92704501
100MP0005645_abnormal_hypothalamus_physiol0.92580554
101MP0002084_abnormal_developmental_patter0.91128992
102MP0003011_delayed_dark_adaptation0.90921243
103MP0003878_abnormal_ear_physiology0.90797355
104MP0005377_hearing/vestibular/ear_phenot0.90797355
105MP0001764_abnormal_homeostasis0.90186209
106MP0000647_abnormal_sebaceous_gland0.89007564
107MP0002085_abnormal_embryonic_tissue0.88354237
108MP0003698_abnormal_male_reproductive0.88100226
109MP0005253_abnormal_eye_physiology0.87171739
110MP0006072_abnormal_retinal_apoptosis0.86992425
111MP0005551_abnormal_eye_electrophysiolog0.86661740
112MP0003315_abnormal_perineum_morphology0.86240975
113MP0001486_abnormal_startle_reflex0.85919591
114MP0002080_prenatal_lethality0.85795148
115MP0009379_abnormal_foot_pigmentation0.85246780
116MP0001286_abnormal_eye_development0.84801567
117MP0000462_abnormal_digestive_system0.84598782
118MP0000470_abnormal_stomach_morphology0.83398314
119MP0001119_abnormal_female_reproductive0.82154894
120MP0008875_abnormal_xenobiotic_pharmacok0.81355517
121MP0002210_abnormal_sex_determination0.81063000
122MP0005410_abnormal_fertilization0.78304297
123MP0003119_abnormal_digestive_system0.78133308
124MP0003880_abnormal_central_pattern0.77334227
125MP0001984_abnormal_olfaction0.76370052
126MP0002161_abnormal_fertility/fecundity0.75894121
127MP0002019_abnormal_tumor_incidence0.75639788
128MP0003984_embryonic_growth_retardation0.74230295
129MP0002177_abnormal_outer_ear0.73983786
130MP0001853_heart_inflammation0.73793748
131MP0004142_abnormal_muscle_tone0.73492487
132MP0005391_vision/eye_phenotype0.73483684
133MP0002088_abnormal_embryonic_growth/wei0.73189763
134MP0003699_abnormal_female_reproductive0.73144918
135MP0001186_pigmentation_phenotype0.73008722
136MP0008007_abnormal_cellular_replicative0.72845180
137MP0003828_pulmonary_edema0.72717061
138MP0004145_abnormal_muscle_electrophysio0.71186926
139MP0004197_abnormal_fetal_growth/weight/0.70836767
140MP0002090_abnormal_vision0.70096266
141MP0005365_abnormal_bile_salt0.70044682
142MP0002160_abnormal_reproductive_system0.68912798
143MP0003755_abnormal_palate_morphology0.67539764
144MP0004147_increased_porphyrin_level0.66217665
145MP0000631_abnormal_neuroendocrine_gland0.65912413
146MP0002163_abnormal_gland_morphology0.65466769
147MP0002139_abnormal_hepatobiliary_system0.64905974
148MP0003137_abnormal_impulse_conducting0.64661364
149MP0006276_abnormal_autonomic_nervous0.64342343
150MP0004782_abnormal_surfactant_physiolog0.63618543
151MP0005084_abnormal_gallbladder_morpholo0.63431858
152MP0003868_abnormal_feces_composition0.63341875
153MP0003077_abnormal_cell_cycle0.62315318
154MP0001177_atelectasis0.62164332
155MP0003121_genomic_imprinting0.61360449
156MP0001346_abnormal_lacrimal_gland0.60098514
157MP0009250_abnormal_appendicular_skeleto0.59785178

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.85582119
2Chromsome breakage (HP:0040012)6.18946288
3Duplicated collecting system (HP:0000081)5.02308409
4Abnormality of the renal collecting system (HP:0004742)4.48611233
5Acute necrotizing encephalopathy (HP:0006965)4.19657712
6Renal cortical cysts (HP:0000803)3.90557723
7Acute encephalopathy (HP:0006846)3.80874247
8Abnormal mitochondria in muscle tissue (HP:0008316)3.80444815
9Upper limb muscle weakness (HP:0003484)3.73452864
10Progressive macrocephaly (HP:0004481)3.48853491
11Mitochondrial inheritance (HP:0001427)3.45833990
12Abnormality of DNA repair (HP:0003254)3.42344306
13Increased CSF lactate (HP:0002490)3.41500722
14Increased hepatocellular lipid droplets (HP:0006565)3.08443803
15Abnormality of the labia minora (HP:0012880)3.08442770
16Hepatocellular necrosis (HP:0001404)3.08134644
17Stomach cancer (HP:0012126)3.05976994
18Abnormality of the preputium (HP:0100587)3.05875748
19Meckel diverticulum (HP:0002245)3.04159068
20Hepatic necrosis (HP:0002605)3.01094420
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.95917657
22Colon cancer (HP:0003003)2.93341050
23Abnormality of the ileum (HP:0001549)2.85799514
24Prostate neoplasm (HP:0100787)2.85534444
25Increased serum lactate (HP:0002151)2.81026472
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77687563
27Abnormality of chromosome stability (HP:0003220)2.76101532
28Cerebral edema (HP:0002181)2.73540248
29Lipid accumulation in hepatocytes (HP:0006561)2.73472428
30Increased serum pyruvate (HP:0003542)2.71398646
31Progressive external ophthalmoplegia (HP:0000590)2.70174356
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69411906
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69411906
34Osteomalacia (HP:0002749)2.67995783
353-Methylglutaconic aciduria (HP:0003535)2.63902744
36Ectopic kidney (HP:0000086)2.62969051
37Duplication of thumb phalanx (HP:0009942)2.62198056
38Lactic acidosis (HP:0003128)2.61848720
39Methylmalonic acidemia (HP:0002912)2.61844696
40Absent/shortened dynein arms (HP:0200106)2.61405238
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.61405238
42Abnormality of pyrimidine metabolism (HP:0004353)2.60183146
43Congenital stationary night blindness (HP:0007642)2.54658768
44Abnormality of the renal cortex (HP:0011035)2.53237128
45Type I transferrin isoform profile (HP:0003642)2.52838677
46Clubbing of toes (HP:0100760)2.51640015
47Decreased central vision (HP:0007663)2.47947416
48Ependymoma (HP:0002888)2.45501644
49Fair hair (HP:0002286)2.43636563
50Abnormality of glycolysis (HP:0004366)2.43594868
51Abnormality of the anterior horn cell (HP:0006802)2.42597723
52Degeneration of anterior horn cells (HP:0002398)2.42597723
53Abnormal lung lobation (HP:0002101)2.42456626
54Microvesicular hepatic steatosis (HP:0001414)2.41605349
55Prolonged partial thromboplastin time (HP:0003645)2.41210715
56Nephroblastoma (Wilms tumor) (HP:0002667)2.38939220
57Febrile seizures (HP:0002373)2.35503412
58Rhabdomyosarcoma (HP:0002859)2.35497918
59Abnormality of the axillary hair (HP:0100134)2.34472524
60Abnormality of secondary sexual hair (HP:0009888)2.34472524
61Abnormality of the pons (HP:0007361)2.34398054
62Congenital sensorineural hearing impairment (HP:0008527)2.30554628
63Abnormality of incisor morphology (HP:0011063)2.30386196
64Renal Fanconi syndrome (HP:0001994)2.28427400
65Embryonal renal neoplasm (HP:0011794)2.24061753
66Tubulointerstitial nephritis (HP:0001970)2.23415068
67Absent radius (HP:0003974)2.23051495
68Medulloblastoma (HP:0002885)2.22318865
69Reticulocytopenia (HP:0001896)2.20841506
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20811923
71Abnormal protein N-linked glycosylation (HP:0012347)2.20811923
72Abnormal protein glycosylation (HP:0012346)2.20811923
73Abnormal glycosylation (HP:0012345)2.20811923
74Septo-optic dysplasia (HP:0100842)2.19495547
75Methylmalonic aciduria (HP:0012120)2.18691258
76Absent septum pellucidum (HP:0001331)2.18478042
77Abnormality of serum amino acid levels (HP:0003112)2.18076709
78Exercise intolerance (HP:0003546)2.17219411
79Hyperglycinemia (HP:0002154)2.15763529
80White forelock (HP:0002211)2.14810420
81Abnormality of methionine metabolism (HP:0010901)2.14550902
82Patchy hypopigmentation of hair (HP:0011365)2.13754854
83Ureteral duplication (HP:0000073)2.13500359
84Increased intramyocellular lipid droplets (HP:0012240)2.12275334
85Megaloblastic anemia (HP:0001889)2.12177161
86Joint hemorrhage (HP:0005261)2.11770172
87Aplastic anemia (HP:0001915)2.11284388
88Aplasia/Hypoplasia of the earlobes (HP:0009906)2.10505034
89Abnormality of the duodenum (HP:0002246)2.10206410
90Absent forearm bone (HP:0003953)2.09385738
91Aplasia involving forearm bones (HP:0009822)2.09385738
92Short tibia (HP:0005736)2.08603717
93Sloping forehead (HP:0000340)2.08525073
94Supernumerary spleens (HP:0009799)2.08319240
95Respiratory failure (HP:0002878)2.04629135
96Male pseudohermaphroditism (HP:0000037)2.04361956
97Cerebral hypomyelination (HP:0006808)2.03822966
98True hermaphroditism (HP:0010459)2.03593044
99Abnormality of lateral ventricle (HP:0030047)2.02979678
100Abnormal respiratory motile cilium morphology (HP:0005938)2.02577486
101Abnormal respiratory epithelium morphology (HP:0012253)2.02577486
102Hypergonadotropic hypogonadism (HP:0000815)2.01132784
103Bone marrow hypocellularity (HP:0005528)2.00921209
104B lymphocytopenia (HP:0010976)2.00092727
105Generalized hypopigmentation of hair (HP:0011358)2.00053804
106Distal lower limb muscle weakness (HP:0009053)1.98985314
107Postnatal microcephaly (HP:0005484)1.98741480
108Nephronophthisis (HP:0000090)1.98284293
109Submucous cleft hard palate (HP:0000176)1.97860612
110Birth length less than 3rd percentile (HP:0003561)1.96911210
111Brushfield spots (HP:0001088)1.96309833
112Prolonged neonatal jaundice (HP:0006579)1.95764084
113Glioma (HP:0009733)1.94974335
114Abnormal ciliary motility (HP:0012262)1.94388225
115Conjugated hyperbilirubinemia (HP:0002908)1.94130666
116Enlarged kidneys (HP:0000105)1.93244707
117Leukodystrophy (HP:0002415)1.93113333
118Proximal tubulopathy (HP:0000114)1.92483501
119Abnormality of the renal medulla (HP:0100957)1.91998362
120Chronic hepatic failure (HP:0100626)1.91973296
121Combined immunodeficiency (HP:0005387)1.91859726
122Horseshoe kidney (HP:0000085)1.91317168
123Optic disc pallor (HP:0000543)1.89544986
124Volvulus (HP:0002580)1.89454627
125Abnormality of the septum pellucidum (HP:0007375)1.89250301
126Pancytopenia (HP:0001876)1.89196191
127Reduced antithrombin III activity (HP:0001976)1.88986356
128Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88144928
129Lethargy (HP:0001254)1.88081182
130Triphalangeal thumb (HP:0001199)1.87971940
131Hypoglycemic coma (HP:0001325)1.87755419
132Attenuation of retinal blood vessels (HP:0007843)1.87673839
133Abnormality of the nasal septum (HP:0000419)1.87487929
134Myelodysplasia (HP:0002863)1.86357253
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86240851
136Aplasia cutis congenita (HP:0001057)1.85754821
137Anal stenosis (HP:0002025)1.84743198
138Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84513118
139Hypoplasia of the pons (HP:0012110)1.84418427
140Short thumb (HP:0009778)1.84118421
141Respiratory difficulties (HP:0002880)1.83986771
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.83567987
143CNS demyelination (HP:0007305)1.83167766
144Atelectasis (HP:0100750)1.82425143
145Abnormality of the carotid arteries (HP:0005344)1.82017124
146Exertional dyspnea (HP:0002875)1.80265889
147Median cleft lip (HP:0000161)1.80011121
148Pancreatic fibrosis (HP:0100732)1.79874987
149Small intestinal stenosis (HP:0012848)1.79163247
150Duodenal stenosis (HP:0100867)1.79163247
151Pancreatic islet-cell hyperplasia (HP:0004510)1.78677376
152Short middle phalanx of the 5th finger (HP:0004220)1.78251364
153Conical tooth (HP:0000698)1.77069218
154Severe combined immunodeficiency (HP:0004430)1.76959349
155Oligohydramnios (HP:0001562)1.76456162
156Agnosia (HP:0010524)1.76209015
157Pancreatic cysts (HP:0001737)1.75945364
158Sparse eyelashes (HP:0000653)1.75312029
159Bifid tongue (HP:0010297)1.74742827
160Parakeratosis (HP:0001036)1.74669006
161Embryonal neoplasm (HP:0002898)1.74516394
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73787942
163Abnormality of alanine metabolism (HP:0010916)1.73787942
164Hyperalaninemia (HP:0003348)1.73787942
165Renal agenesis (HP:0000104)1.73546121
166Abnormality of the incisor (HP:0000676)1.73252053
167Abnormal spermatogenesis (HP:0008669)1.72200666
168Congenital hepatic fibrosis (HP:0002612)1.70669325
169Supernumerary bones of the axial skeleton (HP:0009144)1.67124293
170Alveolar cell carcinoma (HP:0006519)1.67058287
171Abnormality of the parietal bone (HP:0002696)1.66888659
172Metaphyseal irregularity (HP:0003025)1.66065327
173Homocystinuria (HP:0002156)1.65629545
174Abnormality of homocysteine metabolism (HP:0010919)1.65629545
175Hypophosphatemic rickets (HP:0004912)1.63913445
176Azoospermia (HP:0000027)1.63868757
177Fetal akinesia sequence (HP:0001989)1.63021977
178Hypothermia (HP:0002045)1.62905784

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.35573249
2ZAK4.65509889
3STK164.45733696
4IRAK43.73892805
5TRIM282.99178551
6CASK2.87397186
7EIF2AK12.86240351
8CDC72.86179386
9PLK42.81646415
10NEK12.80930940
11VRK22.64744084
12INSRR2.62468900
13MST42.60383849
14TNIK2.46758948
15MAP4K22.25446805
16EIF2AK22.16159729
17IRAK22.09899251
18IRAK11.97707395
19SRPK11.94727482
20MKNK21.85035802
21GRK11.84418793
22PDK21.84165921
23NEK61.81786826
24EPHA21.71540805
25TXK1.70175390
26AKT31.69723189
27BLK1.58003093
28TTK1.57108970
29MARK11.52487404
30MAP3K141.51197939
31STK38L1.41116012
32PASK1.40259717
33BUB11.36945876
34BRD41.31393131
35SCYL21.30626803
36ADRBK21.27328040
37BRSK21.26112598
38MAP3K121.19149793
39NUAK11.18901213
40YES11.18120202
41MKNK11.18008237
42NLK1.17862588
43FLT31.10883453
44NME21.10096656
45BMPR1B1.09262700
46TLK11.09215658
47TESK21.05835393
48RPS6KA41.05213224
49VRK11.02316714
50CSNK1G30.95636557
51CSNK1G10.94942217
52PKN10.92189583
53BCKDK0.89636981
54PNCK0.89544540
55TEC0.89395873
56BRSK10.89271319
57PBK0.88325042
58CHEK20.85825320
59ATR0.83337641
60CDK30.82888559
61TAF10.81612572
62MAP3K40.81308265
63PLK30.80913320
64PIK3CA0.80597063
65CSNK1A1L0.78363226
66MAPK70.77922692
67TSSK60.77253127
68BMPR20.75564190
69CSNK1G20.74314103
70PIK3CG0.74209761
71MAPK130.71923825
72TIE10.71633762
73EPHA30.71389706
74NEK20.70612058
75STK30.70343896
76CDK190.69699592
77GRK70.68504030
78AURKA0.65997040
79BCR0.63499546
80PLK10.63200323
81STK390.61226304
82IKBKB0.60083662
83CLK10.59650421
84MUSK0.57615161
85OBSCN0.57430750
86LIMK10.56098590
87SGK20.55633864
88MAP2K70.55189461
89LATS10.55187379
90CSNK2A20.54963706
91FGFR10.54913803
92BRAF0.52814749
93PINK10.52275078
94DAPK10.51197723
95FRK0.50719643
96DYRK30.49817004
97TNK20.49055212
98IKBKE0.49014549
99ATM0.47931732
100DYRK20.47708638
101TAOK30.47525321
102TGFBR10.46828318
103PRKCE0.46449102
104PRKCI0.46252772
105RPS6KA50.42700096
106WEE10.41634108
107STK40.41078134
108MINK10.40098334
109WNK40.39606351
110MAP3K80.38707387
111PLK20.37452185
112CDK70.37070512
113LYN0.36435625
114MAP3K50.36230783
115EIF2AK30.36162180
116PRKAA20.35286298
117STK100.34643369
118MAPK150.34374923
119CHUK0.33668613
120CSNK1E0.33253946
121SIK30.33198586
122AURKB0.32815271
123PAK40.32447835
124ACVR1B0.31677274
125TESK10.31573045
126PRPF4B0.31172207
127WNK30.31038738
128OXSR10.30531966
129CDC42BPA0.30489666
130ERBB30.30347524
131CDK20.30302407
132CSNK2A10.30007712
133KIT0.29874289
134CCNB10.29120644
135ERBB40.28507876
136CAMK2D0.28304643
137CDK80.27595956
138STK240.27198310
139NME10.25920397
140JAK30.25845027
141CAMK2B0.25637701
142CHEK10.23322221
143PRKG10.21870052
144SGK10.21534350
145CAMK2G0.20266596
146CDK10.20037566
147FGFR40.19673157

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.91556984
2Oxidative phosphorylation_Homo sapiens_hsa001902.77340803
3Non-homologous end-joining_Homo sapiens_hsa034502.76050052
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.47410366
5Parkinsons disease_Homo sapiens_hsa050122.46654967
6Homologous recombination_Homo sapiens_hsa034402.38010118
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35777724
8RNA polymerase_Homo sapiens_hsa030202.35403604
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.25406117
10Ribosome_Homo sapiens_hsa030102.22593232
11RNA transport_Homo sapiens_hsa030132.22355554
12Phototransduction_Homo sapiens_hsa047442.09376438
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03389659
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.02170141
15Basal transcription factors_Homo sapiens_hsa030221.99751321
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.97049558
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95198299
18One carbon pool by folate_Homo sapiens_hsa006701.88261545
19Huntingtons disease_Homo sapiens_hsa050161.83844435
20Sphingolipid metabolism_Homo sapiens_hsa006001.81884957
21Vitamin B6 metabolism_Homo sapiens_hsa007501.80262981
22Vitamin digestion and absorption_Homo sapiens_hsa049771.74381999
23Pyrimidine metabolism_Homo sapiens_hsa002401.71651669
24Retinol metabolism_Homo sapiens_hsa008301.70266706
25beta-Alanine metabolism_Homo sapiens_hsa004101.66872409
26Propanoate metabolism_Homo sapiens_hsa006401.66163821
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57120979
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.54861042
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.51130470
30Pyruvate metabolism_Homo sapiens_hsa006201.47942035
31Arachidonic acid metabolism_Homo sapiens_hsa005901.47270715
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46751863
33Nucleotide excision repair_Homo sapiens_hsa034201.45418913
34Mismatch repair_Homo sapiens_hsa034301.45221635
35Alzheimers disease_Homo sapiens_hsa050101.44504952
36Histidine metabolism_Homo sapiens_hsa003401.43302594
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42458307
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42427466
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41432624
40Fatty acid elongation_Homo sapiens_hsa000621.36816617
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28630065
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28618334
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26921825
44Purine metabolism_Homo sapiens_hsa002301.26919035
45ABC transporters_Homo sapiens_hsa020101.25378598
46Linoleic acid metabolism_Homo sapiens_hsa005911.24762106
47Ether lipid metabolism_Homo sapiens_hsa005651.19220091
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19115765
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18726531
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18492474
51Tryptophan metabolism_Homo sapiens_hsa003801.13655012
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10283075
53Autoimmune thyroid disease_Homo sapiens_hsa053201.09153903
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08614371
55Oocyte meiosis_Homo sapiens_hsa041141.03914549
56Regulation of autophagy_Homo sapiens_hsa041401.02675951
57p53 signaling pathway_Homo sapiens_hsa041151.02528544
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01228162
59Other glycan degradation_Homo sapiens_hsa005111.01012889
60Proteasome_Homo sapiens_hsa030501.00463477
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00121872
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98620852
63Steroid biosynthesis_Homo sapiens_hsa001000.96349102
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.96243584
65Graft-versus-host disease_Homo sapiens_hsa053320.95744573
66mRNA surveillance pathway_Homo sapiens_hsa030150.95249156
67Hematopoietic cell lineage_Homo sapiens_hsa046400.95069915
68Arginine and proline metabolism_Homo sapiens_hsa003300.94059151
69Staphylococcus aureus infection_Homo sapiens_hsa051500.91629897
70Primary immunodeficiency_Homo sapiens_hsa053400.91201174
71Carbon metabolism_Homo sapiens_hsa012000.91084202
72Nicotine addiction_Homo sapiens_hsa050330.89347105
73Tyrosine metabolism_Homo sapiens_hsa003500.88645628
74Caffeine metabolism_Homo sapiens_hsa002320.88333998
75Peroxisome_Homo sapiens_hsa041460.88118872
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.86590629
77Phenylalanine metabolism_Homo sapiens_hsa003600.86446725
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85639959
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84373353
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84166697
81Cardiac muscle contraction_Homo sapiens_hsa042600.82571877
82Complement and coagulation cascades_Homo sapiens_hsa046100.81863628
83Lysine degradation_Homo sapiens_hsa003100.81637355
84DNA replication_Homo sapiens_hsa030300.81375441
85Protein export_Homo sapiens_hsa030600.81146778
86Chemical carcinogenesis_Homo sapiens_hsa052040.80998953
87Allograft rejection_Homo sapiens_hsa053300.80657583
88RNA degradation_Homo sapiens_hsa030180.80219132
89Biosynthesis of amino acids_Homo sapiens_hsa012300.79995665
90Folate biosynthesis_Homo sapiens_hsa007900.78911949
91Base excision repair_Homo sapiens_hsa034100.77810358
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76611986
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71954193
94Measles_Homo sapiens_hsa051620.70402940
95Systemic lupus erythematosus_Homo sapiens_hsa053220.69726640
96Taste transduction_Homo sapiens_hsa047420.69425994
97Butanoate metabolism_Homo sapiens_hsa006500.68735976
98Metabolic pathways_Homo sapiens_hsa011000.66282324
99Asthma_Homo sapiens_hsa053100.65769982
100Selenocompound metabolism_Homo sapiens_hsa004500.65007385
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64472436
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64341527
103Ovarian steroidogenesis_Homo sapiens_hsa049130.63747966
104Rheumatoid arthritis_Homo sapiens_hsa053230.60818051
105Cell cycle_Homo sapiens_hsa041100.60643302
106Spliceosome_Homo sapiens_hsa030400.59897500
107Circadian rhythm_Homo sapiens_hsa047100.55149369
108N-Glycan biosynthesis_Homo sapiens_hsa005100.53191085
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52315315
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51888180
111Collecting duct acid secretion_Homo sapiens_hsa049660.51355885
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.50523580
113Fatty acid metabolism_Homo sapiens_hsa012120.50282910
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49705535
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.47385551
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44860035
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44833846
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44637319
119Glutathione metabolism_Homo sapiens_hsa004800.44117958
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43868558
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42964463
122Herpes simplex infection_Homo sapiens_hsa051680.42579948
123Sulfur relay system_Homo sapiens_hsa041220.42311006
124Fatty acid degradation_Homo sapiens_hsa000710.42093521
125Basal cell carcinoma_Homo sapiens_hsa052170.40574401
126Starch and sucrose metabolism_Homo sapiens_hsa005000.40064597
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39288713
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38483900
129Renin-angiotensin system_Homo sapiens_hsa046140.38406372
130Epstein-Barr virus infection_Homo sapiens_hsa051690.35261133
131Sulfur metabolism_Homo sapiens_hsa009200.34638222
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28402214
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25732643
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20437560
135Nitrogen metabolism_Homo sapiens_hsa009100.19399812
136Olfactory transduction_Homo sapiens_hsa047400.15114564
137TGF-beta signaling pathway_Homo sapiens_hsa043500.11939322
138Pentose phosphate pathway_Homo sapiens_hsa000300.09228963
139Vibrio cholerae infection_Homo sapiens_hsa051100.08209880

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