MTERF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.48360172
2axon ensheathment in central nervous system (GO:0032291)5.48360172
3response to pheromone (GO:0019236)4.96767110
4regulation of regulatory T cell differentiation (GO:0045589)4.89173460
5negative regulation of cell killing (GO:0031342)4.85682513
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.85682513
7negative thymic T cell selection (GO:0045060)4.71499899
8proteasome assembly (GO:0043248)4.68563932
9positive regulation of gamma-delta T cell activation (GO:0046645)4.66998451
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.64863423
11negative T cell selection (GO:0043383)4.52384490
12regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.45908964
13response to interleukin-15 (GO:0070672)4.45479515
14regulation of B cell receptor signaling pathway (GO:0050855)4.32819654
15cellular response to interleukin-15 (GO:0071350)4.26717370
16tolerance induction (GO:0002507)4.19774481
17negative regulation of protein oligomerization (GO:0032460)4.12738908
18cullin deneddylation (GO:0010388)4.09728255
19positive regulation of granulocyte differentiation (GO:0030854)4.09062122
20lateral sprouting from an epithelium (GO:0060601)4.00899655
21interferon-gamma secretion (GO:0072643)4.00565060
22regulation of gamma-delta T cell differentiation (GO:0045586)3.96377980
23L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.92251415
24mesenchymal-epithelial cell signaling (GO:0060638)3.89860728
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84670720
26regulation of gamma-delta T cell activation (GO:0046643)3.78665847
27regulation of isotype switching to IgG isotypes (GO:0048302)3.75576400
28protein deneddylation (GO:0000338)3.74882779
29protein neddylation (GO:0045116)3.73530337
30amino acid salvage (GO:0043102)3.69630913
31L-methionine salvage (GO:0071267)3.69630913
32L-methionine biosynthetic process (GO:0071265)3.69630913
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.67991627
34protein-cofactor linkage (GO:0018065)3.66718794
35nucleotide transmembrane transport (GO:1901679)3.66104781
36positive regulation of interleukin-17 production (GO:0032740)3.65827180
37GTP biosynthetic process (GO:0006183)3.60899076
38GPI anchor biosynthetic process (GO:0006506)3.60228814
39positive regulation of T cell differentiation in thymus (GO:0033089)3.54174831
40viral mRNA export from host cell nucleus (GO:0046784)3.44967009
41negative regulation of T cell mediated immunity (GO:0002710)3.44756679
42B cell receptor signaling pathway (GO:0050853)3.44144711
43thymic T cell selection (GO:0045061)3.38435353
44ribosomal small subunit biogenesis (GO:0042274)3.37939274
45GPI anchor metabolic process (GO:0006505)3.37425073
46T cell migration (GO:0072678)3.35572043
47N-acetylneuraminate metabolic process (GO:0006054)3.32366059
48polyketide metabolic process (GO:0030638)3.31845592
49doxorubicin metabolic process (GO:0044598)3.31845592
50daunorubicin metabolic process (GO:0044597)3.31845592
51ribosomal small subunit assembly (GO:0000028)3.31426452
52activated T cell proliferation (GO:0050798)3.28847089
53glycerophospholipid catabolic process (GO:0046475)3.28656248
54viral transcription (GO:0019083)3.24878517
55termination of RNA polymerase III transcription (GO:0006386)3.23487732
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.23487732
57T cell selection (GO:0045058)3.22556335
58maturation of SSU-rRNA (GO:0030490)3.20405163
59negative regulation of adaptive immune response (GO:0002820)3.18119850
60otic vesicle formation (GO:0030916)3.17106827
61translational termination (GO:0006415)3.15276345
62positive T cell selection (GO:0043368)3.13844085
63phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.12436197
64guanosine-containing compound biosynthetic process (GO:1901070)3.12403428
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10892610
66regulation of B cell differentiation (GO:0045577)3.09217041
67negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09166339
68negative regulation of translation, ncRNA-mediated (GO:0040033)3.09166339
69regulation of translation, ncRNA-mediated (GO:0045974)3.09166339
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08932337
71rRNA modification (GO:0000154)3.07135716
72regulation of alpha-beta T cell proliferation (GO:0046640)3.05231240
73positive thymic T cell selection (GO:0045059)3.04737830
74protein K11-linked deubiquitination (GO:0035871)2.99727382
75ribosomal large subunit biogenesis (GO:0042273)2.99544315
76UTP biosynthetic process (GO:0006228)2.98851877
77negative regulation of lymphocyte mediated immunity (GO:0002707)2.97714272
78positive regulation of protein homodimerization activity (GO:0090073)2.96326648
79mesenchymal cell differentiation involved in kidney development (GO:0072161)2.95988547
80mesenchymal cell differentiation involved in renal system development (GO:2001012)2.95988547
81cartilage morphogenesis (GO:0060536)2.95684999
827-methylguanosine mRNA capping (GO:0006370)2.94326392
83positive regulation of respiratory burst (GO:0060267)2.93925953
84positive regulation of alpha-beta T cell proliferation (GO:0046641)2.92904022
85regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.89456649
86DNA deamination (GO:0045006)2.87982258
87regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.87607660
88deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.87400292
89regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.87304780
90positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.87304780
91mesonephros development (GO:0001823)2.87022751
92positive regulation of B cell differentiation (GO:0045579)2.86195200
93RNA capping (GO:0036260)2.85688113
947-methylguanosine RNA capping (GO:0009452)2.85688113
95negative regulation of ligase activity (GO:0051352)2.84618344
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.84618344
97negative regulation of cAMP-mediated signaling (GO:0043951)2.84513334
98negative regulation of interleukin-2 production (GO:0032703)2.83700725
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83057394
100positive regulation of interleukin-2 production (GO:0032743)2.82936971
101positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82192548
102protein polyglutamylation (GO:0018095)2.81609487
103dendritic cell chemotaxis (GO:0002407)2.81396139
104positive regulation of CREB transcription factor activity (GO:0032793)2.80709796
105cellular extravasation (GO:0045123)2.80043641
106methionine biosynthetic process (GO:0009086)2.79592262
107B cell homeostasis (GO:0001782)2.78782004
108histone H3-K4 trimethylation (GO:0080182)2.77334963
109positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.76543080
110regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.76543080
111fatty acid elongation (GO:0030497)2.76176546
112peptidyl-histidine modification (GO:0018202)2.75634956
113cotranslational protein targeting to membrane (GO:0006613)2.75391417
114mannosylation (GO:0097502)2.75279711
115antigen receptor-mediated signaling pathway (GO:0050851)2.74514934
116DNA integration (GO:0015074)2.74270595
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74023951
118positive regulation of isotype switching (GO:0045830)2.73661879
119establishment of protein localization to mitochondrial membrane (GO:0090151)2.73110710
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73020706
121preassembly of GPI anchor in ER membrane (GO:0016254)2.71663575
122regulation of interleukin-2 production (GO:0032663)2.71649049
123Arp2/3 complex-mediated actin nucleation (GO:0034314)2.71575319
124antigen processing and presentation of endogenous antigen (GO:0019883)2.71534296
125rRNA methylation (GO:0031167)2.70847821
126regulation of non-canonical Wnt signaling pathway (GO:2000050)2.70157127
127embryonic forelimb morphogenesis (GO:0035115)2.68714373
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68637854
129pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67548286
130regulation of mitochondrial translation (GO:0070129)2.67286545
131base-excision repair, AP site formation (GO:0006285)2.67039101
132UTP metabolic process (GO:0046051)2.66089398
133protein targeting to ER (GO:0045047)2.65965911
134S-adenosylmethionine metabolic process (GO:0046500)2.64203867
135negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.62881763
136L-serine metabolic process (GO:0006563)2.62523174
137brain morphogenesis (GO:0048854)2.60907447
138epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60800420
139translational elongation (GO:0006414)2.60557090
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60123695
141presynaptic membrane organization (GO:0097090)2.59774544
142histone H3-K9 modification (GO:0061647)2.57441453
143CENP-A containing nucleosome assembly (GO:0034080)2.57359817
144leukotriene biosynthetic process (GO:0019370)2.56938233
145regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.56466294
146ncRNA 3-end processing (GO:0043628)2.55889026
147establishment of protein localization to endoplasmic reticulum (GO:0072599)2.55615645
148histone H3-K36 demethylation (GO:0070544)2.54114551
149protein localization to endoplasmic reticulum (GO:0070972)2.53885350
150dendritic cell migration (GO:0036336)2.53720266
151midgut development (GO:0007494)2.53204241
152positive regulation of DNA recombination (GO:0045911)2.52337808
153regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.52284858
154spliceosomal snRNP assembly (GO:0000387)2.52220565
155protein complex biogenesis (GO:0070271)2.52140754
156regulation of interleukin-2 biosynthetic process (GO:0045076)2.51829460
157regulation of MHC class II biosynthetic process (GO:0045346)2.51692906
158interferon-gamma production (GO:0032609)2.50885332
159CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.50225362
160mesenchymal cell proliferation (GO:0010463)2.49561188
161mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49074996
162mitochondrial respiratory chain complex I assembly (GO:0032981)2.49074996
163NADH dehydrogenase complex assembly (GO:0010257)2.49074996
164ribonucleoprotein complex biogenesis (GO:0022613)2.48989531
165regulation of T cell mediated cytotoxicity (GO:0001914)2.48893699
166epithelial cilium movement (GO:0003351)2.48839005
167histone lysine demethylation (GO:0070076)2.48510031
168actin nucleation (GO:0045010)2.48244441
169cellular protein complex disassembly (GO:0043624)2.48209921
170short-term memory (GO:0007614)2.48159058
171regulation of granulocyte differentiation (GO:0030852)2.47214715
172respiratory chain complex IV assembly (GO:0008535)2.47191539
173positive regulation of histone deacetylation (GO:0031065)2.46491793
174kinetochore assembly (GO:0051382)2.46347943
175establishment of protein localization to Golgi (GO:0072600)2.46089931
176methionine metabolic process (GO:0006555)2.45952223
177signal complex assembly (GO:0007172)2.45582845
178viral life cycle (GO:0019058)2.44705981
179negative regulation of leukocyte mediated immunity (GO:0002704)2.44541456
180lymphocyte homeostasis (GO:0002260)2.44518682
181T cell receptor signaling pathway (GO:0050852)2.44343412
182sulfur amino acid biosynthetic process (GO:0000097)2.44300078
183mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.44201483
184regulation of hexokinase activity (GO:1903299)2.43557619
185regulation of glucokinase activity (GO:0033131)2.43557619
186protein targeting to Golgi (GO:0000042)2.43425358
187negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.43215184
188peptidyl-lysine methylation (GO:0018022)2.42229215
189cellular component biogenesis (GO:0044085)2.41986084
190response to redox state (GO:0051775)2.41958180
191histone demethylation (GO:0016577)2.41718125
192C-terminal protein lipidation (GO:0006501)2.41591975
193negative regulation of glycoprotein biosynthetic process (GO:0010561)2.40699066
194positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.40207264
195negative regulation of epithelial to mesenchymal transition (GO:0010719)2.40142684
196limb bud formation (GO:0060174)2.38930976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.64487109
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.61594915
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.52562795
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.37309516
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.33711282
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.92766809
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.87874853
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.51000038
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.50783627
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.43320277
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.33390605
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28492774
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.96356570
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.90016232
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.86564570
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.78827935
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78232584
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68565847
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65812911
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60286324
21RUNX_20019798_ChIP-Seq_JUKART_Human2.55099986
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50970820
23EZH2_22144423_ChIP-Seq_EOC_Human2.41021888
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25163595
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.24932298
26ZNF274_21170338_ChIP-Seq_K562_Hela2.17621372
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.17220106
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16416818
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13211094
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09971280
31DCP1A_22483619_ChIP-Seq_HELA_Human2.07194621
32IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06815684
33IRF1_19129219_ChIP-ChIP_H3396_Human2.03542243
34MYB_26560356_Chip-Seq_TH2_Human2.00075801
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.91949812
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87289007
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84514717
38GATA3_27048872_Chip-Seq_THYMUS_Human1.83057073
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82956254
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81884317
41VDR_23849224_ChIP-Seq_CD4+_Human1.80008349
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78944265
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78722481
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75998680
45XRN2_22483619_ChIP-Seq_HELA_Human1.75883312
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75400526
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74032583
48IGF1R_20145208_ChIP-Seq_DFB_Human1.73521646
49CIITA_25753668_ChIP-Seq_RAJI_Human1.71942580
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67694409
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66981832
52SCL_19346495_ChIP-Seq_HPC-7_Human1.65913606
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65699799
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62419050
55FUS_26573619_Chip-Seq_HEK293_Human1.59675124
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.58912073
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57090594
58MYB_26560356_Chip-Seq_TH1_Human1.55019463
59TTF2_22483619_ChIP-Seq_HELA_Human1.54453625
60FOXP3_21729870_ChIP-Seq_TREG_Human1.53731297
61GATA3_26560356_Chip-Seq_TH2_Human1.50127586
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50028725
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49624877
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49236878
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48897452
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.48194647
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.47287863
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45028553
69EWS_26573619_Chip-Seq_HEK293_Human1.41554026
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40951703
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40160299
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38928792
73MYC_22102868_ChIP-Seq_BL_Human1.38868167
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38384909
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38014965
76ELK1_19687146_ChIP-ChIP_HELA_Human1.37731611
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33897697
78GABP_19822575_ChIP-Seq_HepG2_Human1.32777836
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32264455
80VDR_22108803_ChIP-Seq_LS180_Human1.31296912
81GBX2_23144817_ChIP-Seq_PC3_Human1.31127193
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30752633
83SOX17_20123909_ChIP-Seq_XEN_Mouse1.26785313
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25100961
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.23842633
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22754763
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22052531
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.21529338
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20538499
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19902488
91MAF_26560356_Chip-Seq_TH1_Human1.19221415
92MYC_18940864_ChIP-ChIP_HL60_Human1.19206466
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19147211
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19147211
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.18598680
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15972111
97E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15955328
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.15766942
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15310985
100HOXB7_26014856_ChIP-Seq_BT474_Human1.13514448
101MAF_26560356_Chip-Seq_TH2_Human1.12538650
102SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10580265
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10298983
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07843447
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07394468
106RNF2_27304074_Chip-Seq_NSC_Mouse1.06847392
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06636745
108UTX_26944678_Chip-Seq_JUKART_Human1.05713279
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05538668
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04107482
111TCF4_23295773_ChIP-Seq_U87_Human1.03650411
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02949448
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01638743
114SMRT_27268052_Chip-Seq_Bcells_Human1.01493260
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01382597
116GATA3_26560356_Chip-Seq_TH1_Human1.01147114
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00383376
118TAF15_26573619_Chip-Seq_HEK293_Human0.99477541
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98167737
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97930381
121HTT_18923047_ChIP-ChIP_STHdh_Human0.97366494
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95485206
123FLI1_21867929_ChIP-Seq_TH2_Mouse0.95422606
124GATA1_22025678_ChIP-Seq_K562_Human0.94978047
125ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94170393
126FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93840402
127TP53_22573176_ChIP-Seq_HFKS_Human0.93724494
128CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93652920
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92480063
130PRDM14_20953172_ChIP-Seq_ESCs_Human0.92348589
131POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92121174
132NFE2_27457419_Chip-Seq_LIVER_Mouse0.91589438
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91578430
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90621867
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90288817
136HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90139163
137BCAT_22108803_ChIP-Seq_LS180_Human0.90025120
138CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89783000
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.89302752
140AR_21572438_ChIP-Seq_LNCaP_Human0.88784799
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.88482351
142TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88447318
143TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86992300
144SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86979405
145ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86753447
146POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86462061
147OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85889310
148SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85628689
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85562044
150EOMES_21245162_ChIP-Seq_HESCs_Human0.84852198
151RUNX1_22412390_ChIP-Seq_EML_Mouse0.84502693
152NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84265040
153STAT3_23295773_ChIP-Seq_U87_Human0.83972589
154MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83970328
155EZH2_27304074_Chip-Seq_ESCs_Mouse0.83707654
156NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82616893
157ER_23166858_ChIP-Seq_MCF-7_Human0.82375114
158FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81685533
159SPI1_23547873_ChIP-Seq_NB4_Human0.81594119
160RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80812317
161SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80810956
162PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79512623
163IRF8_27001747_Chip-Seq_BMDM_Mouse0.79441552
164CRX_20693478_ChIP-Seq_RETINA_Mouse0.79298222
165REST_18959480_ChIP-ChIP_MESCs_Mouse0.79266272
166SPI1_23127762_ChIP-Seq_K562_Human0.79071343
167SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78833533
168KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77406841
169FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76930247
170SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76663982
171POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75755931
172P300_19829295_ChIP-Seq_ESCs_Human0.75522514
173GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.75148341
174FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75138980
175PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74795327
176SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73559402
177GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72534611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation3.73458424
2MP0003136_yellow_coat_color3.31427662
3MP0003195_calcinosis3.20476498
4MP0003763_abnormal_thymus_physiology2.80281274
5MP0010030_abnormal_orbit_morphology2.77004170
6MP0008877_abnormal_DNA_methylation2.72906672
7MP0001835_abnormal_antigen_presentation2.50322250
8MP0003123_paternal_imprinting2.48116075
9MP0001800_abnormal_humoral_immune2.45965148
10MP0005503_abnormal_tendon_morphology2.40153813
11MP0000566_synostosis2.30697610
12MP0002102_abnormal_ear_morphology2.21039887
13MP0005645_abnormal_hypothalamus_physiol2.20147347
14MP0003718_maternal_effect2.18787678
15MP0005671_abnormal_response_to2.17341224
16MP0003806_abnormal_nucleotide_metabolis2.14819185
17MP0009384_cardiac_valve_regurgitation2.14158536
18MP0002938_white_spotting2.09019923
19MP0002282_abnormal_trachea_morphology2.08935479
20MP0009379_abnormal_foot_pigmentation2.08501818
21MP0003950_abnormal_plasma_membrane2.07745299
22MP0001529_abnormal_vocalization2.06191586
23MP0003122_maternal_imprinting1.97339654
24MP0001346_abnormal_lacrimal_gland1.96500123
25MP0002249_abnormal_larynx_morphology1.95448700
26MP0000762_abnormal_tongue_morphology1.93531534
27MP0008932_abnormal_embryonic_tissue1.90337351
28MP0003942_abnormal_urinary_system1.89354177
29MP0005310_abnormal_salivary_gland1.87952038
30MP0005000_abnormal_immune_tolerance1.86501201
31MP0003787_abnormal_imprinting1.86047411
32MP0009250_abnormal_appendicular_skeleto1.85177520
33MP0005387_immune_system_phenotype1.84569662
34MP0001790_abnormal_immune_system1.84569662
35MP0003937_abnormal_limbs/digits/tail_de1.82278334
36MP0004043_abnormal_pH_regulation1.81654831
37MP0002398_abnormal_bone_marrow1.79401586
38MP0009333_abnormal_splenocyte_physiolog1.78781661
39MP0001986_abnormal_taste_sensitivity1.75120374
40MP0002723_abnormal_immune_serum1.74392719
41MP0000703_abnormal_thymus_morphology1.73038612
42MP0003436_decreased_susceptibility_to1.72504974
43MP0002420_abnormal_adaptive_immunity1.72178489
44MP0003121_genomic_imprinting1.72057846
45MP0000685_abnormal_immune_system1.70615714
46MP0000049_abnormal_middle_ear1.68107598
47MP0001819_abnormal_immune_cell1.64981555
48MP0005464_abnormal_platelet_physiology1.64467396
49MP0005646_abnormal_pituitary_gland1.62505233
50MP0002132_abnormal_respiratory_system1.62417935
51MP0001293_anophthalmia1.62093450
52MP0005451_abnormal_body_composition1.56534366
53MP0002452_abnormal_antigen_presenting1.54621928
54MP0002693_abnormal_pancreas_physiology1.53651394
55MP0000689_abnormal_spleen_morphology1.53531890
56MP0001661_extended_life_span1.51437819
57MP0000716_abnormal_immune_system1.50487623
58MP0005551_abnormal_eye_electrophysiolog1.49510087
59MP0000678_abnormal_parathyroid_gland1.48082422
60MP0003724_increased_susceptibility_to1.45642728
61MP0003646_muscle_fatigue1.44615397
62MP0002909_abnormal_adrenal_gland1.42071190
63MP0003011_delayed_dark_adaptation1.38206376
64MP0004130_abnormal_muscle_cell1.37646014
65MP0003693_abnormal_embryo_hatching1.36145098
66MP0008961_abnormal_basal_metabolism1.35762069
67MP0003755_abnormal_palate_morphology1.33880640
68MP0003938_abnormal_ear_development1.33542415
69MP0008872_abnormal_physiological_respon1.33135352
70MP0003866_abnormal_defecation1.31569486
71MP0004142_abnormal_muscle_tone1.31280617
72MP0002932_abnormal_joint_morphology1.30035190
73MP0006292_abnormal_olfactory_placode1.29857429
74MP0002722_abnormal_immune_system1.29811283
75MP0004381_abnormal_hair_follicle1.28907824
76MP0005171_absent_coat_pigmentation1.25820774
77MP0006036_abnormal_mitochondrial_physio1.24943359
78MP0002876_abnormal_thyroid_physiology1.23821341
79MP0003385_abnormal_body_wall1.23243785
80MP0001485_abnormal_pinna_reflex1.23235005
81MP0008438_abnormal_cutaneous_collagen1.22305138
82MP0002638_abnormal_pupillary_reflex1.20347762
83MP0008995_early_reproductive_senescence1.20040294
84MP0003786_premature_aging1.19679375
85MP0002277_abnormal_respiratory_mucosa1.18791045
86MP0008058_abnormal_DNA_repair1.18557331
87MP0006072_abnormal_retinal_apoptosis1.15766201
88MP0002429_abnormal_blood_cell1.15692212
89MP0008057_abnormal_DNA_replication1.13676701
90MP0001501_abnormal_sleep_pattern1.13584205
91MP0004957_abnormal_blastocyst_morpholog1.11893111
92MP0010094_abnormal_chromosome_stability1.10815573
93MP0010329_abnormal_lipoprotein_level1.10180718
94MP0002210_abnormal_sex_determination1.09247267
95MP0005025_abnormal_response_to1.08339784
96MP0003315_abnormal_perineum_morphology1.07042338
97MP0004133_heterotaxia1.06804064
98MP0004134_abnormal_chest_morphology1.06646134
99MP0001944_abnormal_pancreas_morphology1.06456389
100MP0009785_altered_susceptibility_to1.06310126
101MP0008875_abnormal_xenobiotic_pharmacok1.04212589
102MP0000537_abnormal_urethra_morphology1.03788064
103MP0004742_abnormal_vestibular_system1.03239410
104MP0008260_abnormal_autophagy1.02700908
105MP0005365_abnormal_bile_salt1.02150100
106MP0005248_abnormal_Harderian_gland1.02132647
107MP0002139_abnormal_hepatobiliary_system1.01281974
108MP0010155_abnormal_intestine_physiology1.00908112
109MP0001727_abnormal_embryo_implantation1.00248630
110MP0002405_respiratory_system_inflammati1.00077508
111MP0003172_abnormal_lysosome_physiology0.98749848
112MP0005508_abnormal_skeleton_morphology0.98500558
113MP0000462_abnormal_digestive_system0.98010115
114MP0002078_abnormal_glucose_homeostasis0.97032628
115MP0005379_endocrine/exocrine_gland_phen0.96997432
116MP0000639_abnormal_adrenal_gland0.96944918
117MP0002148_abnormal_hypersensitivity_rea0.96097933
118MP0002928_abnormal_bile_duct0.96031704
119MP0005535_abnormal_body_temperature0.95678900
120MP0002138_abnormal_hepatobiliary_system0.94992821
121MP0003252_abnormal_bile_duct0.93861299
122MP0000613_abnormal_salivary_gland0.93459299
123MP0000465_gastrointestinal_hemorrhage0.93033326
124MP0005220_abnormal_exocrine_pancreas0.92716812
125MP0001984_abnormal_olfaction0.92658785
126MP0008004_abnormal_stomach_pH0.92411814
127MP0002160_abnormal_reproductive_system0.91949030
128MP0000653_abnormal_sex_gland0.91931797
129MP0003943_abnormal_hepatobiliary_system0.91671073
130MP0001845_abnormal_inflammatory_respons0.91342832
131MP0002163_abnormal_gland_morphology0.90402953
132MP0005253_abnormal_eye_physiology0.89487588
133MP0009745_abnormal_behavioral_response0.89391665
134MP0001905_abnormal_dopamine_level0.88171212
135MP0002837_dystrophic_cardiac_calcinosis0.87654744
136MP0001929_abnormal_gametogenesis0.87534421
137MP0002127_abnormal_cardiovascular_syste0.85651621
138MP0002177_abnormal_outer_ear0.84951778
139MP0006276_abnormal_autonomic_nervous0.84741955
140MP0002166_altered_tumor_susceptibility0.84319625
141MP0001873_stomach_inflammation0.83594812
142MP0002233_abnormal_nose_morphology0.83196892
143MP0005187_abnormal_penis_morphology0.82384600
144MP0002109_abnormal_limb_morphology0.81700939
145MP0001145_abnormal_male_reproductive0.80941959
146MP0000604_amyloidosis0.80629191
147MP0002332_abnormal_exercise_endurance0.80620519
148MP0005423_abnormal_somatic_nervous0.80519420
149MP0005266_abnormal_metabolism0.80359069
150MP0003077_abnormal_cell_cycle0.80012668
151MP0000569_abnormal_digit_pigmentation0.79128217
152MP0000681_abnormal_thyroid_gland0.78835658
153MP0009046_muscle_twitch0.78397985
154MP0002116_abnormal_craniofacial_bone0.78005037
155MP0004147_increased_porphyrin_level0.77970864
156MP0000778_abnormal_nervous_system0.77660026
157MP0003936_abnormal_reproductive_system0.77634788
158MP0003698_abnormal_male_reproductive0.77464579
159MP0005195_abnormal_posterior_eye0.77344472
160MP0000015_abnormal_ear_pigmentation0.77262947
161MP0000163_abnormal_cartilage_morphology0.77178306
162MP0002419_abnormal_innate_immunity0.76930331
163MP0001119_abnormal_female_reproductive0.76212851
164MP0001188_hyperpigmentation0.76201935
165MP0003567_abnormal_fetal_cardiomyocyte0.75790352
166MP0004885_abnormal_endolymph0.75391096
167MP0003935_abnormal_craniofacial_develop0.75166932
168MP0000026_abnormal_inner_ear0.75083571
169MP0003303_peritoneal_inflammation0.75000448
170MP0003045_fibrosis0.74749782
171MP0000372_irregular_coat_pigmentation0.74522081
172MP0000428_abnormal_craniofacial_morphol0.74356218
173MP0005395_other_phenotype0.74280144
174MP0008569_lethality_at_weaning0.74253546
175MP0002114_abnormal_axial_skeleton0.74051238
176MP0001340_abnormal_eyelid_morphology0.73919437
177MP0005075_abnormal_melanosome_morpholog0.73916738
178MP0000631_abnormal_neuroendocrine_gland0.73726738
179MP0005389_reproductive_system_phenotype0.72819727
180MP0003186_abnormal_redox_activity0.72444388
181MP0004036_abnormal_muscle_relaxation0.71892112
182MP0002396_abnormal_hematopoietic_system0.71412353
183MP0005448_abnormal_energy_balance0.70368661

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.01863095
2Panhypogammaglobulinemia (HP:0003139)3.82978582
3Hyperlipoproteinemia (HP:0010980)3.57778700
4Increased hepatocellular lipid droplets (HP:0006565)3.57229727
5Parakeratosis (HP:0001036)3.52250273
6Stomatitis (HP:0010280)3.40135784
7Lipid accumulation in hepatocytes (HP:0006561)3.38625851
8Ketoacidosis (HP:0001993)3.24472895
9Renal Fanconi syndrome (HP:0001994)3.20629633
10Cerebral hypomyelination (HP:0006808)3.12059491
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.10882371
12Renal cortical cysts (HP:0000803)3.01668654
13Homocystinuria (HP:0002156)2.95986362
14Abnormality of homocysteine metabolism (HP:0010919)2.95986362
15Prolonged bleeding time (HP:0003010)2.93174409
16Reticulocytopenia (HP:0001896)2.79795541
17Partial duplication of thumb phalanx (HP:0009944)2.75172857
18Partial duplication of the phalanx of hand (HP:0009999)2.73853615
19Abnormality of the renal cortex (HP:0011035)2.73344833
20Recurrent corneal erosions (HP:0000495)2.72796716
21IgG deficiency (HP:0004315)2.72372583
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71468832
23Nasolacrimal duct obstruction (HP:0000579)2.69978578
24Hypomagnesemia (HP:0002917)2.69465073
25Papilledema (HP:0001085)2.69270171
26White forelock (HP:0002211)2.67179513
27True hermaphroditism (HP:0010459)2.64680658
28Abnormality of glycolysis (HP:0004366)2.63960199
29Increased serum pyruvate (HP:0003542)2.63960199
30Chronic hepatic failure (HP:0100626)2.63735709
31Mitochondrial inheritance (HP:0001427)2.62558625
32Abnormality of vitamin B metabolism (HP:0004340)2.60222286
33Patchy hypopigmentation of hair (HP:0011365)2.60142343
34Broad-based gait (HP:0002136)2.59432360
35Agammaglobulinemia (HP:0004432)2.58500958
36Breast hypoplasia (HP:0003187)2.58419028
37Acute necrotizing encephalopathy (HP:0006965)2.57247503
38Ketosis (HP:0001946)2.57221655
39Abnormality of incisor morphology (HP:0011063)2.54644574
40Hyperinsulinemic hypoglycemia (HP:0000825)2.54395574
41T lymphocytopenia (HP:0005403)2.53491018
42Increased CSF lactate (HP:0002490)2.47385150
43Elevated erythrocyte sedimentation rate (HP:0003565)2.47317629
44Hypoglycemic coma (HP:0001325)2.45466584
45Ureteral duplication (HP:0000073)2.43925137
46Coronal craniosynostosis (HP:0004440)2.42628849
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42521350
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.42285436
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41709703
50Protruding tongue (HP:0010808)2.40683097
51Hepatocellular necrosis (HP:0001404)2.39307301
52Abnormality of the parietal bone (HP:0002696)2.39024605
53Abnormality of T cell number (HP:0011839)2.35598327
54Midline defect of the nose (HP:0004122)2.34761190
55Abnormality of endocrine pancreas physiology (HP:0012093)2.34302135
56Abnormality of the pancreatic islet cells (HP:0006476)2.34302135
57Pulmonary infiltrates (HP:0002113)2.33111741
58Abnormal mitochondria in muscle tissue (HP:0008316)2.31556721
59Birth length less than 3rd percentile (HP:0003561)2.30324979
60Abnormal ciliary motility (HP:0012262)2.28752219
61Septo-optic dysplasia (HP:0100842)2.28619709
62Duplicated collecting system (HP:0000081)2.28380983
63Abnormal rod and cone electroretinograms (HP:0008323)2.28319708
64Conical tooth (HP:0000698)2.28033018
65Abnormality of the metopic suture (HP:0005556)2.27492865
66Hypoglycemic seizures (HP:0002173)2.27251494
67Duplication of thumb phalanx (HP:0009942)2.26308226
68Abnormality of T cells (HP:0002843)2.26004564
69Sensory axonal neuropathy (HP:0003390)2.25593809
70Increased serum lactate (HP:0002151)2.25517904
71Calf muscle hypertrophy (HP:0008981)2.24711624
72Clumsiness (HP:0002312)2.23754585
73Concave nail (HP:0001598)2.21324399
74Stenosis of the external auditory canal (HP:0000402)2.21311639
75Gastrointestinal stroma tumor (HP:0100723)2.20888268
76Pustule (HP:0200039)2.20121974
77Molar tooth sign on MRI (HP:0002419)2.18721228
78Abnormality of midbrain morphology (HP:0002418)2.18721228
79Acute encephalopathy (HP:0006846)2.18448920
80Gonadotropin excess (HP:0000837)2.18322348
81Increased intramyocellular lipid droplets (HP:0012240)2.17530283
82Vasculitis (HP:0002633)2.17380492
83Abnormality of the lacrimal duct (HP:0011481)2.17223264
84Lymphopenia (HP:0001888)2.16652653
85Poor coordination (HP:0002370)2.16364065
86Abnormality of renal resorption (HP:0011038)2.16289023
87Absent septum pellucidum (HP:0001331)2.15731117
88Alacrima (HP:0000522)2.14382079
89Flat capital femoral epiphysis (HP:0003370)2.13969215
90IgM deficiency (HP:0002850)2.13903393
91Bile duct proliferation (HP:0001408)2.12845543
92Abnormal biliary tract physiology (HP:0012439)2.12845543
93Abnormality of lateral ventricle (HP:0030047)2.11782691
94Methylmalonic aciduria (HP:0012120)2.11084788
95Abnormal respiratory motile cilium physiology (HP:0012261)2.10847693
96Progressive inability to walk (HP:0002505)2.09970230
97Abnormality of the nasolacrimal system (HP:0000614)2.09767047
98Abnormality of the renal collecting system (HP:0004742)2.09131599
99Methylmalonic acidemia (HP:0002912)2.08599462
100Prominent metopic ridge (HP:0005487)2.08564777
101Abnormality of the labia minora (HP:0012880)2.07381831
102Pancreatic fibrosis (HP:0100732)2.06783713
103Abnormality of the renal medulla (HP:0100957)2.06754412
104Hyperventilation (HP:0002883)2.06506308
105Abnormality of the aortic arch (HP:0012303)2.05615473
106Lactic acidosis (HP:0003128)2.05439706
107Nephronophthisis (HP:0000090)2.05309937
108Adrenal hypoplasia (HP:0000835)2.04958691
109Respiratory difficulties (HP:0002880)2.04525276
110Muscle hypertrophy of the lower extremities (HP:0008968)2.04419142
111Abnormality of the incisor (HP:0000676)2.04300208
112Stomach cancer (HP:0012126)2.04289211
113Basal cell carcinoma (HP:0002671)2.04215320
114Abnormal umbilical cord blood vessels (HP:0011403)2.03068694
115Single umbilical artery (HP:0001195)2.03068694
116Abnormality of the fetal cardiovascular system (HP:0010948)2.03068694
117Macrocytic anemia (HP:0001972)2.02789619
118Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02576567
119Anteriorly placed anus (HP:0001545)2.02498751
120Tubulointerstitial nephritis (HP:0001970)2.02370353
121Recurrent sinusitis (HP:0011108)2.02200865
122Abnormality of the septum pellucidum (HP:0007375)2.01940925
123Type 2 muscle fiber atrophy (HP:0003554)2.01101917
124Abnormality of methionine metabolism (HP:0010901)2.00801174
125Hepatic necrosis (HP:0002605)1.98608308
126Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97702275
127Severe combined immunodeficiency (HP:0004430)1.96908760
128Recurrent bronchitis (HP:0002837)1.96804268
129Hyperkalemia (HP:0002153)1.96154107
130Bifid tongue (HP:0010297)1.95724696
131Amyotrophic lateral sclerosis (HP:0007354)1.95402004
132Genetic anticipation (HP:0003743)1.94738404
133Central scotoma (HP:0000603)1.94443217
134Hypoplastic left heart (HP:0004383)1.94419845
135Congenital stationary night blindness (HP:0007642)1.94031514
136Abnormality of T cell physiology (HP:0011840)1.93207005
137Episodic fever (HP:0001954)1.93109434
138Double outlet right ventricle (HP:0001719)1.92807946
139Congenital malformation of the right heart (HP:0011723)1.92807946
140Thyroid-stimulating hormone excess (HP:0002925)1.92616721
141Congenital sensorineural hearing impairment (HP:0008527)1.91728689
142Neoplasm of the tracheobronchial system (HP:0100552)1.91679652
143Fair hair (HP:0002286)1.91610980
144Encephalitis (HP:0002383)1.91352211
145Aplasia involving forearm bones (HP:0009822)1.90706473
146Absent forearm bone (HP:0003953)1.90706473
147Medial flaring of the eyebrow (HP:0010747)1.90422547
148Progressive macrocephaly (HP:0004481)1.89745397
149Supernumerary spleens (HP:0009799)1.89531542
150Pancreatic cysts (HP:0001737)1.88847551
151Hyperglycinemia (HP:0002154)1.88706459
152Pancreatic islet-cell hyperplasia (HP:0004510)1.88625595
153Abnormal hemoglobin (HP:0011902)1.88520280
154Recurrent fungal infections (HP:0002841)1.87485287
155Absent radius (HP:0003974)1.87184070
156Spastic paraparesis (HP:0002313)1.87021811
157Microvesicular hepatic steatosis (HP:0001414)1.86466903
158Hypergonadotropic hypogonadism (HP:0000815)1.86023619
159Anencephaly (HP:0002323)1.85624712
160Abnormality of the clitoris (HP:0000056)1.85130308
161Leukodystrophy (HP:0002415)1.83998160
162Exertional dyspnea (HP:0002875)1.82119603
163Triphalangeal thumb (HP:0001199)1.81677982
164Anophthalmia (HP:0000528)1.81636386
165Meningitis (HP:0001287)1.81212249
166Abnormality of cells of the lymphoid lineage (HP:0012140)1.80951876
167Increased muscle lipid content (HP:0009058)1.80800697
168Gait imbalance (HP:0002141)1.80654171
169Hypoplasia of the radius (HP:0002984)1.80616083
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.79473755
171Recurrent cutaneous fungal infections (HP:0011370)1.78569013
172Chronic mucocutaneous candidiasis (HP:0002728)1.78569013
173Sclerocornea (HP:0000647)1.78253440
174Epistaxis (HP:0000421)1.77760686
175Albinism (HP:0001022)1.76901418
176Inflammation of the large intestine (HP:0002037)1.76860932
177Abnormality of serum amino acid levels (HP:0003112)1.76286750
178Abnormality of vitamin metabolism (HP:0100508)1.76098230
179Congenital primary aphakia (HP:0007707)1.75778542
180Retinal dysplasia (HP:0007973)1.75184941
181Hyperglycemia (HP:0003074)1.74812925
182Chronic diarrhea (HP:0002028)1.74276095
183Abnormality of the prostate (HP:0008775)1.73351307
184Aplasia/hypoplasia of the uterus (HP:0008684)1.72906830
185Gingival bleeding (HP:0000225)1.72658469
186Hypoplastic heart (HP:0001961)1.71120651
187Mediastinal lymphadenopathy (HP:0100721)1.70449584
188Alveolar cell carcinoma (HP:0006519)1.68845640
189Microcytic anemia (HP:0001935)1.68812080
190Recurrent viral infections (HP:0004429)1.68615160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA33.84039637
2BUB13.68808036
3MAP4K13.27604565
4PBK3.14043597
5CASK3.06058966
6TAOK33.01880580
7SIK32.98285430
8FRK2.88534898
9CAMKK22.65942364
10RIPK42.49643903
11PASK2.35492954
12STK392.31030994
13TEC2.19908179
14BCR2.15524636
15SIK22.13939561
16NME22.09941345
17AKT32.09077640
18SRPK12.06145264
19STK162.05136550
20TNK22.00407263
21BCKDK1.98772053
22STK38L1.96939181
23TLK11.95916892
24WEE11.83945086
25BTK1.81688916
26TXK1.81128771
27NTRK31.80629417
28LATS21.77187585
29INSRR1.76692006
30OXSR11.74374863
31PLK41.72034849
32CDK81.71246702
33CAMKK11.70565362
34SYK1.64515148
35BRAF1.63607586
36GRK11.61107572
37ACVR1B1.60088761
38EIF2AK11.58454756
39TYK21.54538095
40ITK1.53087530
41VRK11.51266596
42ZAK1.50954960
43MUSK1.45093649
44TTK1.44234827
45PINK11.43710118
46GRK61.42518674
47MAP3K71.41755401
48FES1.40017608
49IKBKB1.34956094
50NLK1.33888524
51DYRK31.29100287
52PLK11.27246542
53TNIK1.24264419
54DYRK21.22701804
55IRAK21.22077751
56LIMK11.21834524
57BMPR1B1.21622032
58CHUK1.21096804
59CSNK1A1L1.19232287
60MAP3K131.18955671
61CSNK1G31.17218726
62LCK1.16936719
63CDK191.16538006
64PHKG21.16200790
65PHKG11.16200790
66FGFR31.14207046
67DAPK21.12804609
68MARK21.09385226
69LYN1.09197574
70IKBKE1.08354543
71JAK11.07091306
72TESK21.05929222
73IRAK41.05325099
74MAPKAPK31.05186294
75SGK21.04066780
76SIK11.03659454
77CSNK1G11.03551965
78MKNK21.02969810
79PRKCH1.02961411
80CDK121.02806130
81TIE11.02035435
82GRK51.01638828
83HCK1.00037645
84MKNK10.95829148
85OBSCN0.93602689
86PRPF4B0.92815983
87PTK2B0.92436899
88AURKA0.90750893
89TSSK60.89208797
90DDR20.89137045
91CHEK20.88613797
92HIPK20.88495203
93MAPK120.87629918
94JAK30.87332500
95PRKCQ0.87079749
96NME10.85478365
97MET0.85022500
98CSF1R0.83611350
99ROCK20.82521614
100NUAK10.82422058
101MAPK110.81756072
102CSK0.81434308
103PNCK0.79736782
104PLK30.78796373
105EPHA40.77865066
106BLK0.76985411
107CAMK2B0.76898872
108LATS10.75475383
109CSNK1G20.74665291
110MARK30.73938054
111STK110.73315842
112PAK30.71940302
113NEK60.71287816
114CAMK1D0.71166424
115ZAP700.70758604
116CDK70.70617077
117IRAK10.70486864
118SGK2230.70452802
119SGK4940.70452802
120PIK3CG0.68965888
121ILK0.68958794
122STK40.68693754
123NTRK20.67979879
124BRD40.67683621
125MAP3K140.67129620
126PIM10.66637193
127MYLK0.66124928
128TAF10.65661857
129PRKD20.65366830
130EPHA20.65110754
131TBK10.64877845
132YES10.63254904
133ATR0.62197555
134CAMK10.62001501
135ERBB40.61447525
136SGK30.61364534
137CLK10.60881202
138PRKAA20.59951593
139MAP3K100.59584136
140AURKB0.59562240
141CSNK2A10.58976319
142BRSK20.58871076
143PDK20.58855306
144PDK30.58027973
145PDK40.58027973
146SGK10.55246530
147MAPK70.55187276
148CAMK2G0.54613611
149PKN10.53499591
150WNK10.52520256
151PRKAA10.51262623
152ARAF0.49737647
153CAMK2D0.49491470
154CAMK40.48786011
155PAK10.48080777
156PDK10.46030440
157WNK30.45882901
158MAPK130.44412618
159ADRBK20.44205448
160CSNK2A20.43796333
161DYRK1B0.43484273
162MAP2K40.42000520
163CAMK1G0.41947418
164FGFR40.41604409
165JAK20.41498064
166PRKCE0.40178296
167FGFR10.39802585
168CCNB10.39194900
169CSNK1A10.38878496
170MST40.38844121
171PLK20.38381391
172DYRK1A0.37909820
173FGFR20.35478284
174WNK40.34863329
175ADRBK10.33069000
176NEK20.32552805
177ABL20.31629469
178RPS6KA50.31017224

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.05022101
2Ribosome_Homo sapiens_hsa030103.63518872
3RNA polymerase_Homo sapiens_hsa030203.26127411
4Proteasome_Homo sapiens_hsa030503.15570330
5T cell receptor signaling pathway_Homo sapiens_hsa046602.82711569
6Type I diabetes mellitus_Homo sapiens_hsa049402.81330878
7Vitamin B6 metabolism_Homo sapiens_hsa007502.78241973
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.76795454
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.49592586
10Oxidative phosphorylation_Homo sapiens_hsa001902.45407385
11B cell receptor signaling pathway_Homo sapiens_hsa046622.35958925
12Protein export_Homo sapiens_hsa030602.29598413
13Selenocompound metabolism_Homo sapiens_hsa004502.13911035
14Basal transcription factors_Homo sapiens_hsa030222.07727328
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.03947908
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99752162
17Spliceosome_Homo sapiens_hsa030401.98338614
18Allograft rejection_Homo sapiens_hsa053301.94771604
19Pyrimidine metabolism_Homo sapiens_hsa002401.92871054
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92570620
21Parkinsons disease_Homo sapiens_hsa050121.91213641
22Graft-versus-host disease_Homo sapiens_hsa053321.91155238
23Folate biosynthesis_Homo sapiens_hsa007901.90649197
24Fanconi anemia pathway_Homo sapiens_hsa034601.90436657
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88930961
26Fatty acid elongation_Homo sapiens_hsa000621.88579582
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88032849
28Homologous recombination_Homo sapiens_hsa034401.85892213
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83513249
30Huntingtons disease_Homo sapiens_hsa050161.62428439
31Measles_Homo sapiens_hsa051621.56198154
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.55413664
33Platelet activation_Homo sapiens_hsa046111.51401332
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49570244
35RNA transport_Homo sapiens_hsa030131.47560264
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46018081
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45915226
38Type II diabetes mellitus_Homo sapiens_hsa049301.43154761
39Base excision repair_Homo sapiens_hsa034101.39615674
40Purine metabolism_Homo sapiens_hsa002301.38491811
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36624191
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36227081
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.35676726
44mTOR signaling pathway_Homo sapiens_hsa041501.33855952
45Chemical carcinogenesis_Homo sapiens_hsa052041.33133337
46Steroid biosynthesis_Homo sapiens_hsa001001.33016994
47One carbon pool by folate_Homo sapiens_hsa006701.32685875
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.31347293
49Retinol metabolism_Homo sapiens_hsa008301.30020911
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29457254
51DNA replication_Homo sapiens_hsa030301.29442017
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28604336
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.28475551
54Alzheimers disease_Homo sapiens_hsa050101.27607617
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.26343070
56Cell cycle_Homo sapiens_hsa041101.26314668
57Chemokine signaling pathway_Homo sapiens_hsa040621.24466799
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23610353
59Non-homologous end-joining_Homo sapiens_hsa034501.23386787
60Nucleotide excision repair_Homo sapiens_hsa034201.23296531
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23253288
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23205532
63Hematopoietic cell lineage_Homo sapiens_hsa046401.22134164
64Mismatch repair_Homo sapiens_hsa034301.22101228
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22076681
66Histidine metabolism_Homo sapiens_hsa003401.21636199
67Glutathione metabolism_Homo sapiens_hsa004801.19043289
68RNA degradation_Homo sapiens_hsa030181.17286701
69Insulin secretion_Homo sapiens_hsa049111.16915138
70Basal cell carcinoma_Homo sapiens_hsa052171.16156252
71Arginine and proline metabolism_Homo sapiens_hsa003301.13653625
72Insulin resistance_Homo sapiens_hsa049311.13596846
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13159161
74Peroxisome_Homo sapiens_hsa041461.10843075
75FoxO signaling pathway_Homo sapiens_hsa040681.08936338
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08923809
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08602625
78Herpes simplex infection_Homo sapiens_hsa051681.06682471
79Propanoate metabolism_Homo sapiens_hsa006401.05272760
80Linoleic acid metabolism_Homo sapiens_hsa005911.04858421
81Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04789227
82Acute myeloid leukemia_Homo sapiens_hsa052211.03198727
83Primary bile acid biosynthesis_Homo sapiens_hsa001201.02202114
84Pyruvate metabolism_Homo sapiens_hsa006201.01593415
85Hedgehog signaling pathway_Homo sapiens_hsa043400.99752341
86Metabolic pathways_Homo sapiens_hsa011000.95818257
87Vitamin digestion and absorption_Homo sapiens_hsa049770.95437688
88Osteoclast differentiation_Homo sapiens_hsa043800.93801881
89Biosynthesis of amino acids_Homo sapiens_hsa012300.93482116
90Regulation of autophagy_Homo sapiens_hsa041400.93208477
91Dorso-ventral axis formation_Homo sapiens_hsa043200.91652716
92Lysine degradation_Homo sapiens_hsa003100.88461103
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.88379852
94Tyrosine metabolism_Homo sapiens_hsa003500.87777950
95Inositol phosphate metabolism_Homo sapiens_hsa005620.87620927
96Phototransduction_Homo sapiens_hsa047440.87376180
97Prolactin signaling pathway_Homo sapiens_hsa049170.87007038
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86223377
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83870234
100Epstein-Barr virus infection_Homo sapiens_hsa051690.83238347
101Butanoate metabolism_Homo sapiens_hsa006500.83165290
102Amphetamine addiction_Homo sapiens_hsa050310.83158590
103Sulfur relay system_Homo sapiens_hsa041220.82937241
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82618967
105ABC transporters_Homo sapiens_hsa020100.81182170
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.80670175
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80249129
108Arachidonic acid metabolism_Homo sapiens_hsa005900.78687093
109Viral carcinogenesis_Homo sapiens_hsa052030.78657978
110Asthma_Homo sapiens_hsa053100.77469229
111Ether lipid metabolism_Homo sapiens_hsa005650.75293199
112Serotonergic synapse_Homo sapiens_hsa047260.74218437
113Glycerolipid metabolism_Homo sapiens_hsa005610.73632769
114Glucagon signaling pathway_Homo sapiens_hsa049220.72850230
115Prostate cancer_Homo sapiens_hsa052150.72671336
116Long-term potentiation_Homo sapiens_hsa047200.71350804
117Cholinergic synapse_Homo sapiens_hsa047250.70246491
118Sphingolipid metabolism_Homo sapiens_hsa006000.70191219
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.69047824
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68404108
121Endometrial cancer_Homo sapiens_hsa052130.67545394
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66795495
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65812957
124Morphine addiction_Homo sapiens_hsa050320.65376686
125Renin secretion_Homo sapiens_hsa049240.64234523
126Oxytocin signaling pathway_Homo sapiens_hsa049210.64178273
127Hepatitis C_Homo sapiens_hsa051600.63130145
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62626804
129Long-term depression_Homo sapiens_hsa047300.61881457
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61830579
131Autoimmune thyroid disease_Homo sapiens_hsa053200.61563679
132VEGF signaling pathway_Homo sapiens_hsa043700.61282299
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60518433
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.60247620
135Pentose phosphate pathway_Homo sapiens_hsa000300.59989562
136Leishmaniasis_Homo sapiens_hsa051400.59621346
137MAPK signaling pathway_Homo sapiens_hsa040100.58262018
138Choline metabolism in cancer_Homo sapiens_hsa052310.58115432
139beta-Alanine metabolism_Homo sapiens_hsa004100.58075810
140Cardiac muscle contraction_Homo sapiens_hsa042600.58075286
141Sulfur metabolism_Homo sapiens_hsa009200.57036484
142Fatty acid degradation_Homo sapiens_hsa000710.55859300
143Non-small cell lung cancer_Homo sapiens_hsa052230.54742154
144Hepatitis B_Homo sapiens_hsa051610.54739038
145Fatty acid metabolism_Homo sapiens_hsa012120.53845042
146Ras signaling pathway_Homo sapiens_hsa040140.53057009
147Carbon metabolism_Homo sapiens_hsa012000.53012791
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52881439
149Tryptophan metabolism_Homo sapiens_hsa003800.52767991
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50019241
151mRNA surveillance pathway_Homo sapiens_hsa030150.49491783
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.48786527
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48119640
154Circadian rhythm_Homo sapiens_hsa047100.48104829
155TNF signaling pathway_Homo sapiens_hsa046680.47653931
156Ovarian steroidogenesis_Homo sapiens_hsa049130.46844974
157Circadian entrainment_Homo sapiens_hsa047130.46841673
158cAMP signaling pathway_Homo sapiens_hsa040240.46478832
159Hippo signaling pathway_Homo sapiens_hsa043900.46402310
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46270512
161Fructose and mannose metabolism_Homo sapiens_hsa000510.45842740
162Dopaminergic synapse_Homo sapiens_hsa047280.45805769
163Complement and coagulation cascades_Homo sapiens_hsa046100.44696229
164Phenylalanine metabolism_Homo sapiens_hsa003600.44215863
165Renal cell carcinoma_Homo sapiens_hsa052110.44207930
166Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44193138
167Olfactory transduction_Homo sapiens_hsa047400.42018963
168Colorectal cancer_Homo sapiens_hsa052100.41077979
169SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40400202
170Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40223835
171TGF-beta signaling pathway_Homo sapiens_hsa043500.38334142
172p53 signaling pathway_Homo sapiens_hsa041150.32659089
173Caffeine metabolism_Homo sapiens_hsa002320.31076877
174Axon guidance_Homo sapiens_hsa043600.30463208
175Nicotine addiction_Homo sapiens_hsa050330.29547536
176Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29184597

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