MTFMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.77417789
2behavioral response to nicotine (GO:0035095)4.65913912
3ribosomal small subunit assembly (GO:0000028)4.49639418
4telomere maintenance via semi-conservative replication (GO:0032201)4.34252795
5DNA strand elongation involved in DNA replication (GO:0006271)4.09891885
6L-fucose catabolic process (GO:0042355)4.07859397
7fucose catabolic process (GO:0019317)4.07859397
8L-fucose metabolic process (GO:0042354)4.07859397
9response to pheromone (GO:0019236)4.06913975
10DNA strand elongation (GO:0022616)3.97083526
11water-soluble vitamin biosynthetic process (GO:0042364)3.96977294
12telomere maintenance via recombination (GO:0000722)3.96906831
13platelet dense granule organization (GO:0060155)3.96445077
14protein-cofactor linkage (GO:0018065)3.94810768
15proteasome assembly (GO:0043248)3.90183358
16CENP-A containing nucleosome assembly (GO:0034080)3.85216580
17telomere maintenance via telomere lengthening (GO:0010833)3.79204652
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76151899
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.75832282
20kynurenine metabolic process (GO:0070189)3.72871161
21tryptophan catabolic process (GO:0006569)3.68980185
22indole-containing compound catabolic process (GO:0042436)3.68980185
23indolalkylamine catabolic process (GO:0046218)3.68980185
24tryptophan metabolic process (GO:0006568)3.68089860
25chromatin remodeling at centromere (GO:0031055)3.64901357
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.62072777
27ATP synthesis coupled proton transport (GO:0015986)3.62072777
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.58584664
29indolalkylamine metabolic process (GO:0006586)3.57275400
30mitotic recombination (GO:0006312)3.56212439
31tRNA methylation (GO:0030488)3.54657518
32DNA replication initiation (GO:0006270)3.53728576
33ubiquinone biosynthetic process (GO:0006744)3.52382022
34maturation of SSU-rRNA (GO:0030490)3.50615000
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.46433452
36termination of RNA polymerase III transcription (GO:0006386)3.46433452
37pseudouridine synthesis (GO:0001522)3.46109791
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.45514020
39preassembly of GPI anchor in ER membrane (GO:0016254)3.44970562
40ribosomal large subunit biogenesis (GO:0042273)3.36134530
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.35339821
42purine nucleobase biosynthetic process (GO:0009113)3.35190631
43cellular ketone body metabolic process (GO:0046950)3.34525655
44ubiquinone metabolic process (GO:0006743)3.31170702
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.29166646
46nucleobase biosynthetic process (GO:0046112)3.28571349
47DNA replication checkpoint (GO:0000076)3.27911296
48rRNA catabolic process (GO:0016075)3.21058235
49transcription-coupled nucleotide-excision repair (GO:0006283)3.20392229
50ribonucleoprotein complex biogenesis (GO:0022613)3.18761651
51ribosome biogenesis (GO:0042254)3.18390792
52S-adenosylmethionine metabolic process (GO:0046500)3.17963152
53mannosylation (GO:0097502)3.17934446
54electron transport chain (GO:0022900)3.16673568
55metallo-sulfur cluster assembly (GO:0031163)3.12045756
56iron-sulfur cluster assembly (GO:0016226)3.12045756
57rRNA modification (GO:0000154)3.11981941
58telomere maintenance (GO:0000723)3.11525279
59kinetochore assembly (GO:0051382)3.11059226
60telomere organization (GO:0032200)3.10909265
61DNA replication-independent nucleosome assembly (GO:0006336)3.10182750
62DNA replication-independent nucleosome organization (GO:0034724)3.10182750
63respiratory electron transport chain (GO:0022904)3.10090679
64viral mRNA export from host cell nucleus (GO:0046784)3.09652074
65ribosomal small subunit biogenesis (GO:0042274)3.07502098
66ketone body metabolic process (GO:1902224)3.06532996
67negative regulation of telomere maintenance (GO:0032205)3.05706972
68mitochondrial respiratory chain complex I assembly (GO:0032981)3.05466365
69NADH dehydrogenase complex assembly (GO:0010257)3.05466365
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05466365
717-methylguanosine mRNA capping (GO:0006370)3.03864132
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.03399763
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03182123
747-methylguanosine RNA capping (GO:0009452)3.02175829
75RNA capping (GO:0036260)3.02175829
76L-methionine salvage (GO:0071267)3.01727185
77L-methionine biosynthetic process (GO:0071265)3.01727185
78amino acid salvage (GO:0043102)3.01727185
79kinetochore organization (GO:0051383)3.01586674
80regulation of mitochondrial translation (GO:0070129)3.01150959
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00736983
82RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99863656
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99863656
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97786304
85histone H2A acetylation (GO:0043968)2.95408547
86mismatch repair (GO:0006298)2.94842146
87anterograde synaptic vesicle transport (GO:0048490)2.94745677
88cellular component biogenesis (GO:0044085)2.94215093
89piRNA metabolic process (GO:0034587)2.93947651
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92816188
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92391351
92protein K6-linked ubiquitination (GO:0085020)2.92039031
93replication fork processing (GO:0031297)2.91900517
94spliceosomal snRNP assembly (GO:0000387)2.91568925
95rRNA processing (GO:0006364)2.91432744
96recombinational repair (GO:0000725)2.89342728
97base-excision repair, AP site formation (GO:0006285)2.88757788
98double-strand break repair via homologous recombination (GO:0000724)2.88238251
99IMP biosynthetic process (GO:0006188)2.87572075
100protein complex biogenesis (GO:0070271)2.86281409
101signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86262541
102signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86262541
103signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86262541
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84688788
105rRNA metabolic process (GO:0016072)2.83635819
106peptidyl-histidine modification (GO:0018202)2.83217840
107positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81768298
108RNA methylation (GO:0001510)2.81631497
109* tRNA processing (GO:0008033)2.81190159
110transcription elongation from RNA polymerase I promoter (GO:0006362)2.80837906
111deoxyribonucleotide catabolic process (GO:0009264)2.79203558
112negative regulation of mast cell activation (GO:0033004)2.78808233
113cullin deneddylation (GO:0010388)2.78779913
114formation of translation preinitiation complex (GO:0001731)2.78220572
115respiratory chain complex IV assembly (GO:0008535)2.78080469
116DNA double-strand break processing (GO:0000729)2.77750656
117* tRNA modification (GO:0006400)2.77445701
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77183064
119signal transduction involved in cell cycle checkpoint (GO:0072395)2.77158486
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76663113
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76663113
122quinone biosynthetic process (GO:1901663)2.76132252
123termination of RNA polymerase I transcription (GO:0006363)2.75995648
124histone exchange (GO:0043486)2.74741113
125prenylation (GO:0097354)2.74251840
126protein prenylation (GO:0018342)2.74251840
127DNA catabolic process, exonucleolytic (GO:0000738)2.73905709
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73070860
129pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.71884797
130signal transduction involved in DNA damage checkpoint (GO:0072422)2.71058223
131signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71058223
132protein localization to cilium (GO:0061512)2.70790346
133maturation of 5.8S rRNA (GO:0000460)2.70602286
134rRNA methylation (GO:0031167)2.70191658
135DNA-dependent DNA replication (GO:0006261)2.69621875
136pyrimidine nucleotide catabolic process (GO:0006244)2.68873921
137DNA synthesis involved in DNA repair (GO:0000731)2.68866957
138sulfation (GO:0051923)2.68468431
139mitochondrial respiratory chain complex assembly (GO:0033108)2.68211867
140IMP metabolic process (GO:0046040)2.67858975
141protein neddylation (GO:0045116)2.67857193
142* ncRNA processing (GO:0034470)2.67825568
143mitotic metaphase plate congression (GO:0007080)2.67324498
144intracellular protein transmembrane import (GO:0044743)2.66556334
145meiotic chromosome segregation (GO:0045132)2.66549989
146detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66509637
147GTP biosynthetic process (GO:0006183)2.66245455
148reciprocal DNA recombination (GO:0035825)2.65777937
149reciprocal meiotic recombination (GO:0007131)2.65777937
150regulation of hexokinase activity (GO:1903299)2.63778123
151regulation of glucokinase activity (GO:0033131)2.63778123
152GPI anchor metabolic process (GO:0006505)2.62796897
153cytochrome complex assembly (GO:0017004)2.62220135
154base-excision repair (GO:0006284)2.61328613
155negative regulation of DNA-dependent DNA replication (GO:2000104)2.61033805
156protein deneddylation (GO:0000338)2.60990387
157protein polyglutamylation (GO:0018095)2.60489259
158male meiosis I (GO:0007141)2.60466318
159axoneme assembly (GO:0035082)2.58702420
160protein import into peroxisome matrix (GO:0016558)2.58505504
161signal peptide processing (GO:0006465)2.57018498
162cellular biogenic amine catabolic process (GO:0042402)2.55945239
163amine catabolic process (GO:0009310)2.55945239
164neural tube formation (GO:0001841)2.54569069
165somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.53949329
166isotype switching (GO:0045190)2.53949329
167somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.53949329
168methionine biosynthetic process (GO:0009086)2.51373318
169cilium morphogenesis (GO:0060271)2.50500519
170indole-containing compound metabolic process (GO:0042430)2.47116399
171regulation of telomere maintenance (GO:0032204)2.45909669
172regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45862790
173DNA demethylation (GO:0080111)2.45846617
174hydrogen ion transmembrane transport (GO:1902600)2.45012213
175kidney morphogenesis (GO:0060993)2.44761816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.72905563
2ZNF274_21170338_ChIP-Seq_K562_Hela4.09034676
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.94089638
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.83863945
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.66608217
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47215644
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.43685243
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.30700696
9VDR_22108803_ChIP-Seq_LS180_Human3.21974694
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21424731
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.08088336
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.87008665
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68636932
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64350287
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59613537
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58772317
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57649605
18VDR_23849224_ChIP-Seq_CD4+_Human2.54717441
19IGF1R_20145208_ChIP-Seq_DFB_Human2.48013408
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42381618
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39082077
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34284930
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28494262
24* SRF_21415370_ChIP-Seq_HL-1_Mouse2.26517899
25FOXP3_21729870_ChIP-Seq_TREG_Human2.25226185
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25167586
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.24948903
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23532284
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14946522
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13363157
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12840942
32POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12458999
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12103840
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11340585
35DCP1A_22483619_ChIP-Seq_HELA_Human2.05214732
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03140757
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01537587
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99801424
39FUS_26573619_Chip-Seq_HEK293_Human1.99271065
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.99022442
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.99007991
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98795579
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.98533452
44ELK1_19687146_ChIP-ChIP_HELA_Human1.96393753
45TAF15_26573619_Chip-Seq_HEK293_Human1.95735658
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95281398
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.89976448
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.86799652
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.85496649
50* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84780912
51CIITA_25753668_ChIP-Seq_RAJI_Human1.84218830
52* GABP_19822575_ChIP-Seq_HepG2_Human1.82537322
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81489208
54XRN2_22483619_ChIP-Seq_HELA_Human1.81408396
55* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81123973
56GBX2_23144817_ChIP-Seq_PC3_Human1.80254868
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79144382
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78260945
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.77968281
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74423008
61* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73677225
62P300_19829295_ChIP-Seq_ESCs_Human1.71342002
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70817861
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70679445
65* TP53_22573176_ChIP-Seq_HFKS_Human1.69844941
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69062072
67TTF2_22483619_ChIP-Seq_HELA_Human1.67192534
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.67021688
69ER_23166858_ChIP-Seq_MCF-7_Human1.66913442
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66867253
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.65379331
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64769907
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.62693355
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61393686
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56132639
76* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50841167
77* FOXA1_25329375_ChIP-Seq_VCAP_Human1.50841167
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49941475
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41974329
80BCAT_22108803_ChIP-Seq_LS180_Human1.38727054
81AR_20517297_ChIP-Seq_VCAP_Human1.37891495
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37569041
83SPI1_23547873_ChIP-Seq_NB4_Human1.34420834
84SOX2_19829295_ChIP-Seq_ESCs_Human1.34356383
85NANOG_19829295_ChIP-Seq_ESCs_Human1.34356383
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33402486
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32199668
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32011581
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31473349
90CBP_20019798_ChIP-Seq_JUKART_Human1.31253670
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31253670
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.29095219
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29011104
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27935459
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27710660
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.27505765
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27248418
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24222484
99MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22644183
100NCOR_22424771_ChIP-Seq_293T_Human1.21834461
101SCL_19346495_ChIP-Seq_HPC-7_Human1.21776475
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20346348
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.20314900
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20239371
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20091779
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18160690
107KDM5A_27292631_Chip-Seq_BREAST_Human1.16000640
108* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14845600
109HOXB7_26014856_ChIP-Seq_BT474_Human1.14523406
110MYC_18940864_ChIP-ChIP_HL60_Human1.14376980
111BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12615721
112TCF4_22108803_ChIP-Seq_LS180_Human1.12380292
113KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11045234
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.10795828
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08767791
116AR_25329375_ChIP-Seq_VCAP_Human1.08683957
117ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08051581
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07919528
119STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06721003
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06000007
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04714565
122AR_21909140_ChIP-Seq_LNCAP_Human1.04453811
123STAT3_23295773_ChIP-Seq_U87_Human1.03603279
124GATA3_26560356_Chip-Seq_TH2_Human1.03092016
125TCF4_23295773_ChIP-Seq_U87_Human1.02214489
126FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01888925
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01682464
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01272399
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01118966
130CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00142601
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98636900
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97300211
133CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96961252
134* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93953045
135* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93545785
136SMAD4_21799915_ChIP-Seq_A2780_Human0.93127235
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93041397
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92552549
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.92497405
140MYC_22102868_ChIP-Seq_BL_Human0.91679096
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.91405167
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91309662
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.90909012
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90630836
145STAT3_18555785_Chip-Seq_ESCs_Mouse0.90410718
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90376581
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89837710
148RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89668637
149RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89668235
150NANOG_20526341_ChIP-Seq_ESCs_Human0.89498481
151HTT_18923047_ChIP-ChIP_STHdh_Human0.89386448
152P53_22387025_ChIP-Seq_ESCs_Mouse0.89045332
153FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88587435
154TP63_19390658_ChIP-ChIP_HaCaT_Human0.84284033
155BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82004906
156LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81832769
157POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80980146
158IRF1_19129219_ChIP-ChIP_H3396_Human0.80341920
159TFEB_21752829_ChIP-Seq_HELA_Human0.77401475
160EWS_26573619_Chip-Seq_HEK293_Human0.74119830
161FLI1_27457419_Chip-Seq_LIVER_Mouse0.73838529
162ELK1_22589737_ChIP-Seq_MCF10A_Human0.73570908
163MYB_26560356_Chip-Seq_TH2_Human0.70870481
164LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70053539
165PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69821642
166EGR1_19374776_ChIP-ChIP_THP-1_Human0.68311263
167SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67679402
168KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66631670
169EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.65528205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.91560830
2MP0006292_abnormal_olfactory_placode3.69413457
3MP0010094_abnormal_chromosome_stability3.47933223
4MP0008058_abnormal_DNA_repair3.44131118
5MP0003111_abnormal_nucleus_morphology3.34166426
6MP0002396_abnormal_hematopoietic_system3.16537595
7MP0003195_calcinosis3.03016155
8MP0001835_abnormal_antigen_presentation2.93795434
9MP0003077_abnormal_cell_cycle2.74681293
10MP0008057_abnormal_DNA_replication2.59875235
11MP0005075_abnormal_melanosome_morpholog2.58463108
12MP0002132_abnormal_respiratory_system2.53094743
13MP0001188_hyperpigmentation2.46480179
14MP0003763_abnormal_thymus_physiology2.41217881
15MP0004957_abnormal_blastocyst_morpholog2.39159581
16MP0002837_dystrophic_cardiac_calcinosis2.36957684
17MP0006072_abnormal_retinal_apoptosis2.35398060
18MP0008007_abnormal_cellular_replicative2.33458360
19MP0005551_abnormal_eye_electrophysiolog2.27474509
20MP0005174_abnormal_tail_pigmentation2.19985318
21MP0000569_abnormal_digit_pigmentation2.12586486
22MP0005671_abnormal_response_to2.10776455
23MP0008875_abnormal_xenobiotic_pharmacok2.08185989
24MP0009697_abnormal_copulation2.05928872
25MP0003646_muscle_fatigue2.03391265
26MP0000566_synostosis1.99235274
27MP0008877_abnormal_DNA_methylation1.96133280
28MP0000015_abnormal_ear_pigmentation1.94179435
29MP0000490_abnormal_crypts_of1.89711380
30MP0005253_abnormal_eye_physiology1.87043172
31MP0005084_abnormal_gallbladder_morpholo1.84186502
32MP0004142_abnormal_muscle_tone1.79292083
33MP0009785_altered_susceptibility_to1.77664851
34MP0004043_abnormal_pH_regulation1.76642760
35MP0009046_muscle_twitch1.72841566
36MP0002398_abnormal_bone_marrow1.72520075
37MP0003011_delayed_dark_adaptation1.72330285
38MP0002095_abnormal_skin_pigmentation1.71223244
39MP0001873_stomach_inflammation1.70993884
40MP0001968_abnormal_touch/_nociception1.70072184
41MP0001800_abnormal_humoral_immune1.67948504
42MP0008872_abnormal_physiological_respon1.67925945
43MP0002254_reproductive_system_inflammat1.65206344
44MP0002148_abnormal_hypersensitivity_rea1.64374267
45MP0004147_increased_porphyrin_level1.62438538
46MP0000427_abnormal_hair_cycle1.61354332
47MP0001819_abnormal_immune_cell1.58767170
48MP0002420_abnormal_adaptive_immunity1.58745978
49MP0009333_abnormal_splenocyte_physiolog1.58210318
50MP0002452_abnormal_antigen_presenting1.57752778
51MP0005645_abnormal_hypothalamus_physiol1.56364028
52MP0003786_premature_aging1.51978751
53MP0000372_irregular_coat_pigmentation1.51361302
54MP0008932_abnormal_embryonic_tissue1.50640105
55MP0002736_abnormal_nociception_after1.48668908
56MP0002723_abnormal_immune_serum1.44433786
57MP0010386_abnormal_urinary_bladder1.43344563
58MP0000689_abnormal_spleen_morphology1.42897841
59MP0000716_abnormal_immune_system1.41311233
60MP0008995_early_reproductive_senescence1.40707275
61MP0004808_abnormal_hematopoietic_stem1.39339507
62MP0001919_abnormal_reproductive_system1.38910756
63MP0001984_abnormal_olfaction1.38473572
64MP0000703_abnormal_thymus_morphology1.37773808
65MP0002160_abnormal_reproductive_system1.36400049
66MP0009745_abnormal_behavioral_response1.34631047
67MP0002429_abnormal_blood_cell1.34346642
68MP0002722_abnormal_immune_system1.33666496
69MP0005025_abnormal_response_to1.32833625
70MP0002419_abnormal_innate_immunity1.29537535
71MP0005000_abnormal_immune_tolerance1.29482769
72MP0002138_abnormal_hepatobiliary_system1.25353582
73MP0002928_abnormal_bile_duct1.22698795
74MP0008260_abnormal_autophagy1.21797970
75MP0003787_abnormal_imprinting1.19713920
76MP0008789_abnormal_olfactory_epithelium1.19552287
77MP0004885_abnormal_endolymph1.18973314
78MP0009379_abnormal_foot_pigmentation1.18887973
79MP0002272_abnormal_nervous_system1.17605542
80MP0001853_heart_inflammation1.17404475
81MP0003718_maternal_effect1.16265598
82MP0003252_abnormal_bile_duct1.15433763
83MP0006035_abnormal_mitochondrial_morpho1.14720877
84MP0001790_abnormal_immune_system1.14202045
85MP0005387_immune_system_phenotype1.14202045
86MP0000631_abnormal_neuroendocrine_gland1.14144688
87MP0004145_abnormal_muscle_electrophysio1.13793196
88MP0002653_abnormal_ependyma_morphology1.12484500
89MP0003806_abnormal_nucleotide_metabolis1.12147634
90MP0001186_pigmentation_phenotype1.11732932
91MP0001764_abnormal_homeostasis1.11345655
92MP0008775_abnormal_heart_ventricle1.10586042
93MP0005389_reproductive_system_phenotype1.10357860
94MP0002938_white_spotting1.09947967
95MP0002019_abnormal_tumor_incidence1.09945144
96MP0000685_abnormal_immune_system1.08930109
97MP0002075_abnormal_coat/hair_pigmentati1.08377816
98MP0002693_abnormal_pancreas_physiology1.07511390
99MP0000313_abnormal_cell_death1.07117492
100MP0002638_abnormal_pupillary_reflex1.06222354
101MP0003436_decreased_susceptibility_to1.05650381
102MP0005410_abnormal_fertilization1.05425513
103MP0002277_abnormal_respiratory_mucosa1.04703748
104MP0001501_abnormal_sleep_pattern1.04184674
105MP0005464_abnormal_platelet_physiology1.03831371
106MP0005332_abnormal_amino_acid1.03648001
107MP0001324_abnormal_eye_pigmentation1.03374673
108MP0001119_abnormal_female_reproductive1.02811996
109MP0001485_abnormal_pinna_reflex1.01785727
110MP0002234_abnormal_pharynx_morphology1.01739773
111MP0006276_abnormal_autonomic_nervous1.00593484
112MP0004782_abnormal_surfactant_physiolog1.00249495
113MP0002163_abnormal_gland_morphology0.99891079
114MP0010155_abnormal_intestine_physiology0.99502523
115MP0002405_respiratory_system_inflammati0.99061659
116MP0000647_abnormal_sebaceous_gland0.98886751
117MP0004215_abnormal_myocardial_fiber0.98658843
118MP0010307_abnormal_tumor_latency0.97924113
119MP0001293_anophthalmia0.97493792
120MP0005379_endocrine/exocrine_gland_phen0.96224162
121MP0000371_diluted_coat_color0.96083158
122MP0002210_abnormal_sex_determination0.95583731
123MP0005409_darkened_coat_color0.94650573
124MP0002102_abnormal_ear_morphology0.93949258
125MP0005195_abnormal_posterior_eye0.93042466
126MP0000465_gastrointestinal_hemorrhage0.92082063
127MP0000350_abnormal_cell_proliferation0.91883438
128MP0003186_abnormal_redox_activity0.90558062
129MP0003136_yellow_coat_color0.88355180
130MP0005171_absent_coat_pigmentation0.88350469
131MP0004381_abnormal_hair_follicle0.87127422
132MP0005499_abnormal_olfactory_system0.86244726
133MP0005394_taste/olfaction_phenotype0.86244726
134MP0003698_abnormal_male_reproductive0.84707307
135MP0001905_abnormal_dopamine_level0.83719751
136MP0001929_abnormal_gametogenesis0.83491805
137MP0003880_abnormal_central_pattern0.83385580
138MP0005167_abnormal_blood-brain_barrier0.82963346
139MP0005646_abnormal_pituitary_gland0.82354974
140MP0005085_abnormal_gallbladder_physiolo0.82184674
141MP0001529_abnormal_vocalization0.81248887
142MP0001986_abnormal_taste_sensitivity0.80143639
143MP0004133_heterotaxia0.78580500
144MP0000383_abnormal_hair_follicle0.77743887
145MP0003315_abnormal_perineum_morphology0.77291661
146MP0002557_abnormal_social/conspecific_i0.76044096
147MP0000538_abnormal_urinary_bladder0.75127231
148MP0001970_abnormal_pain_threshold0.74719720
149MP0000230_abnormal_systemic_arterial0.74428255
150MP0001145_abnormal_male_reproductive0.74352796
151MP0005408_hypopigmentation0.73318916
152MP0006036_abnormal_mitochondrial_physio0.72853917
153MP0002229_neurodegeneration0.72850992
154MP0001845_abnormal_inflammatory_respons0.72565179
155MP0000653_abnormal_sex_gland0.72021442
156MP0002933_joint_inflammation0.71366018
157MP0002751_abnormal_autonomic_nervous0.71353377
158MP0009764_decreased_sensitivity_to0.71288496
159MP0002876_abnormal_thyroid_physiology0.68760737
160MP0003943_abnormal_hepatobiliary_system0.68605982

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.40200242
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.00598522
3Abnormality of midbrain morphology (HP:0002418)3.88549944
4Molar tooth sign on MRI (HP:0002419)3.88549944
5Chromsome breakage (HP:0040012)3.80357300
6Congenital stationary night blindness (HP:0007642)3.63456478
7Oral leukoplakia (HP:0002745)3.52215186
8Nephronophthisis (HP:0000090)3.37144703
9Reticulocytopenia (HP:0001896)3.34859480
10Type II lissencephaly (HP:0007260)3.22856225
11IgM deficiency (HP:0002850)3.15547420
12Birth length less than 3rd percentile (HP:0003561)3.05067273
13Abnormality of the preputium (HP:0100587)2.99359313
14Acute encephalopathy (HP:0006846)2.98978930
15Type I transferrin isoform profile (HP:0003642)2.98794894
16Progressive macrocephaly (HP:0004481)2.94682400
17Lipid accumulation in hepatocytes (HP:0006561)2.93512400
18Abnormality of the renal cortex (HP:0011035)2.89703337
19Abnormality of the renal medulla (HP:0100957)2.84387753
20Abnormality of DNA repair (HP:0003254)2.82492191
21Abnormality of chromosome stability (HP:0003220)2.82387966
22Attenuation of retinal blood vessels (HP:0007843)2.76128727
23Medial flaring of the eyebrow (HP:0010747)2.69279421
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.68576214
25Abnormality of alanine metabolism (HP:0010916)2.68276518
26Hyperalaninemia (HP:0003348)2.68276518
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68276518
28Thrombocytosis (HP:0001894)2.68136358
29Severe visual impairment (HP:0001141)2.66097330
30Myositis (HP:0100614)2.64374874
31Abolished electroretinogram (ERG) (HP:0000550)2.63642689
32Bone marrow hypocellularity (HP:0005528)2.62914783
33Petechiae (HP:0000967)2.60034153
34Myelodysplasia (HP:0002863)2.57518826
35Meckel diverticulum (HP:0002245)2.56993419
36Tubular atrophy (HP:0000092)2.56568903
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.55764533
38Abnormality of the ileum (HP:0001549)2.54792569
39Pancytopenia (HP:0001876)2.54063203
40Pancreatic cysts (HP:0001737)2.53213878
41Chronic otitis media (HP:0000389)2.53151272
42Pancreatic fibrosis (HP:0100732)2.52062401
43Type 2 muscle fiber atrophy (HP:0003554)2.51856127
44Premature graying of hair (HP:0002216)2.50639737
45Retrobulbar optic neuritis (HP:0100654)2.50498511
46Optic neuritis (HP:0100653)2.50498511
47Reduced antithrombin III activity (HP:0001976)2.50321029
48Lymphoma (HP:0002665)2.45870769
49Congenital, generalized hypertrichosis (HP:0004540)2.43608529
50Duplicated collecting system (HP:0000081)2.43323251
51Methylmalonic acidemia (HP:0002912)2.42711125
52Hypothermia (HP:0002045)2.39736993
53True hermaphroditism (HP:0010459)2.39433751
54Abnormality of the renal collecting system (HP:0004742)2.37135474
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36863356
56Pulmonary fibrosis (HP:0002206)2.36665651
57Abnormal rod and cone electroretinograms (HP:0008323)2.35919132
58Optic nerve coloboma (HP:0000588)2.35720393
59Cystic liver disease (HP:0006706)2.34977870
60Pendular nystagmus (HP:0012043)2.34797752
61Decreased central vision (HP:0007663)2.33258797
62Panhypogammaglobulinemia (HP:0003139)2.32386892
63Optic disc pallor (HP:0000543)2.31701933
64Sclerocornea (HP:0000647)2.31254108
65Sloping forehead (HP:0000340)2.30550620
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29118581
67Abnormal protein N-linked glycosylation (HP:0012347)2.29118581
68Abnormal protein glycosylation (HP:0012346)2.29118581
69Abnormal glycosylation (HP:0012345)2.29118581
70Lactic acidosis (HP:0003128)2.27432914
71Cerebellar dysplasia (HP:0007033)2.27023922
72Polydipsia (HP:0001959)2.26368693
73Abnormal drinking behavior (HP:0030082)2.26368693
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24554072
75Progressive inability to walk (HP:0002505)2.24467940
76Abnormal spermatogenesis (HP:0008669)2.24114747
77Large for gestational age (HP:0001520)2.22661420
78Abnormal hair whorl (HP:0010721)2.22108693
79Bile duct proliferation (HP:0001408)2.21090934
80Abnormal biliary tract physiology (HP:0012439)2.21090934
81Elevated erythrocyte sedimentation rate (HP:0003565)2.21070888
82Clubbing of toes (HP:0100760)2.20631623
833-Methylglutaconic aciduria (HP:0003535)2.19799018
84Encephalitis (HP:0002383)2.18512891
85* Increased serum lactate (HP:0002151)2.17888379
86Abnormality of the pons (HP:0007361)2.17624179
87Exertional dyspnea (HP:0002875)2.16161559
88Rough bone trabeculation (HP:0100670)2.15808060
89Abnormal lung lobation (HP:0002101)2.15790107
90Orchitis (HP:0100796)2.15711843
91Cerebral edema (HP:0002181)2.14546178
92Microvesicular hepatic steatosis (HP:0001414)2.13968610
93Abnormality of B cell number (HP:0010975)2.13399329
94B lymphocytopenia (HP:0010976)2.13399329
95Ketoacidosis (HP:0001993)2.13150449
96Chronic obstructive pulmonary disease (HP:0006510)2.11684862
97Obstructive lung disease (HP:0006536)2.11684862
98Hypoplasia of the pons (HP:0012110)2.11324127
99Methylmalonic aciduria (HP:0012120)2.09417134
100Keratoconus (HP:0000563)2.08962375
101Increased corneal curvature (HP:0100692)2.08962375
102Mitochondrial inheritance (HP:0001427)2.08250206
103Furrowed tongue (HP:0000221)2.08218962
104Cellular immunodeficiency (HP:0005374)2.08149532
105Inability to walk (HP:0002540)2.06890965
106Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04781310
107Ketosis (HP:0001946)2.04767732
108Stomatitis (HP:0010280)2.04670694
109Increased hepatocellular lipid droplets (HP:0006565)2.04299775
110IgG deficiency (HP:0004315)2.03904196
111Aplasia/Hypoplasia of the tongue (HP:0010295)2.03876079
112Respiratory difficulties (HP:0002880)2.03640564
113Abnormality of the anterior horn cell (HP:0006802)2.01951219
114Degeneration of anterior horn cells (HP:0002398)2.01951219
115Hepatocellular necrosis (HP:0001404)2.01557752
116Muscle fiber atrophy (HP:0100295)2.00912195
117Lissencephaly (HP:0001339)2.00873174
118Meningitis (HP:0001287)1.99588970
119Aplasia/hypoplasia of the uterus (HP:0008684)1.99489117
120Abnormality of the prostate (HP:0008775)1.99130827
121Microretrognathia (HP:0000308)1.98102637
122Granulocytopenia (HP:0001913)1.95285921
123Duodenal stenosis (HP:0100867)1.94885497
124Small intestinal stenosis (HP:0012848)1.94885497
125Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94800789
126Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94800789
127* Increased CSF lactate (HP:0002490)1.93828518
128Albinism (HP:0001022)1.92357271
129Severe muscular hypotonia (HP:0006829)1.91934025
130Congenital primary aphakia (HP:0007707)1.90925488
131Hypoplasia of the fovea (HP:0007750)1.90686730
132Aplasia/Hypoplasia of the fovea (HP:0008060)1.90686730
133Anencephaly (HP:0002323)1.90442076
134Ectopic kidney (HP:0000086)1.90396263
135Gait imbalance (HP:0002141)1.89923035
136Lethargy (HP:0001254)1.89338461
137Abnormal number of erythroid precursors (HP:0012131)1.88967668
138Congenital hepatic fibrosis (HP:0002612)1.88635694
139Hyperglycinuria (HP:0003108)1.88120985
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.87547840
141Acute necrotizing encephalopathy (HP:0006965)1.86113585
142Renal cortical cysts (HP:0000803)1.84642730
143Renal Fanconi syndrome (HP:0001994)1.84547100
144Increased intramyocellular lipid droplets (HP:0012240)1.84220546
145Male pseudohermaphroditism (HP:0000037)1.83878684
146Nephrogenic diabetes insipidus (HP:0009806)1.83545585
147Absent thumb (HP:0009777)1.83324272
148Concave nail (HP:0001598)1.82364680
149Acute lymphatic leukemia (HP:0006721)1.81519940
150Patellar aplasia (HP:0006443)1.80823331
151Cerebral hypomyelination (HP:0006808)1.80539068
152Recurrent abscess formation (HP:0002722)1.80312368
153Triphalangeal thumb (HP:0001199)1.79542799
154Polyuria (HP:0000103)1.79468181
155Impulsivity (HP:0100710)1.77580319
156Abnormality of serum amino acid levels (HP:0003112)1.77174901
157Respiratory failure (HP:0002878)1.76304019
158Decreased circulating renin level (HP:0003351)1.75644302
159CNS demyelination (HP:0007305)1.75608034
160Glycosuria (HP:0003076)1.74861129
161Abnormality of urine glucose concentration (HP:0011016)1.74861129
162Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74134257
163Hyperventilation (HP:0002883)1.74093055
164Abnormality of the metopic suture (HP:0005556)1.73379563
165Colon cancer (HP:0003003)1.72257889
166Chronic hepatic failure (HP:0100626)1.70839960
167Abnormal mitochondria in muscle tissue (HP:0008316)1.70385298
168Hepatic necrosis (HP:0002605)1.70380238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.90798577
2STK163.19350473
3PLK42.84079926
4ZAK2.71339535
5MAP4K22.63484613
6SRPK12.59721983
7GRK12.57916013
8IRAK42.57109347
9BUB12.56056995
10TXK2.54571238
11WNK42.52884787
12PIM22.42991902
13WEE12.34358968
14WNK32.28750161
15EIF2AK32.22278591
16IRAK32.20813602
17EIF2AK12.20679584
18VRK12.03675012
19TAOK32.01187945
20TEC1.96044331
21MAP4K11.93520909
22PINK11.79128075
23CDC71.75203919
24BTK1.69077492
25PASK1.68315169
26SIK31.65806063
27CCNB11.65699893
28MKNK21.64420815
29MUSK1.60806546
30OXSR11.57279973
31MKNK11.56907259
32TSSK61.56040716
33CDK81.52788994
34MST41.50166495
35INSRR1.48476934
36ATR1.46972929
37EIF2AK21.46971232
38YES11.45293968
39NEK21.45214947
40BRAF1.40339957
41PLK31.36538924
42TTK1.34565403
43MAP3K141.33952563
44STK391.32104228
45VRK21.32073643
46KIT1.31609163
47ACVR1B1.30524876
48PLK11.27824318
49AKT31.26862986
50TRIM281.25517485
51MAPK131.24474617
52MAP3K41.22829745
53TAOK21.22515463
54TGFBR11.18182762
55BMPR21.10686823
56TNIK1.09370036
57MAPKAPK31.07524711
58NEK11.07176817
59CDK71.06848293
60NEK61.04241870
61ADRBK11.03718464
62DAPK21.03626960
63DYRK31.01876630
64CASK1.01313421
65NUAK11.00736125
66SYK0.99995633
67ADRBK20.97624719
68IKBKE0.97424068
69CHEK20.96736431
70PHKG20.96712987
71PHKG10.96712987
72PAK30.95398197
73AURKB0.94812734
74IKBKB0.94187418
75NME10.92127635
76CAMKK20.91361445
77CDK190.89894553
78TLK10.88398392
79BRD40.88144105
80DYRK20.87325898
81TIE10.86988245
82CSNK1G20.86449796
83PIM10.85904227
84LYN0.85438069
85CLK10.84891228
86FLT30.84792732
87CSNK1G10.84705107
88PDK20.84261759
89ERBB30.84033798
90BMPR1B0.83796010
91PRKCE0.83589084
92TBK10.81961045
93CSNK1G30.80254500
94ARAF0.78907205
95MAP2K70.76709533
96TESK20.75419220
97PRKCG0.74500487
98BRSK20.74337086
99NME20.73206550
100TYK20.72190179
101STK240.66879173
102PRKCI0.66553459
103NEK90.65116537
104CDK40.64153840
105CSNK1A1L0.63672642
106BLK0.63446491
107ZAP700.62706107
108PRPF4B0.62377007
109STK38L0.61872767
110MAP2K60.61639498
111JAK30.61491573
112MAPKAPK50.60732501
113SGK20.59072894
114STK100.57698379
115LCK0.57550718
116RPS6KB20.56492610
117CSF1R0.56294639
118PNCK0.56156722
119PRKCQ0.55357220
120CSNK2A10.54780747
121TAF10.54555812
122FES0.53984686
123STK40.53550640
124RAF10.53065094
125MAP3K120.52975622
126AURKA0.52460824
127BCKDK0.51934525
128PLK20.51800446
129MYLK0.50880980
130CHEK10.49623161
131ITK0.49545242
132STK30.47555430
133BCR0.47461738
134OBSCN0.46682957
135RPS6KA50.46559982
136ATM0.45937437
137MAPK70.44361233
138PTK2B0.44208330
139MAP2K30.42860182
140PIK3CA0.42159296
141NLK0.38998100
142IRAK10.37395684
143CHUK0.37123210
144CDK20.37108996
145CSNK1A10.36766915
146TRPM70.36417646
147CAMK2A0.36008033
148PRKACA0.35826997
149PKN10.35318949
150GRK70.34581057
151CSNK2A20.34113495
152NTRK30.32879008
153PRKCA0.30750644
154MARK30.28803681

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.42687217
2Mismatch repair_Homo sapiens_hsa034303.96845914
3RNA polymerase_Homo sapiens_hsa030203.58214161
4Base excision repair_Homo sapiens_hsa034103.46077803
5Proteasome_Homo sapiens_hsa030503.33966445
6Homologous recombination_Homo sapiens_hsa034403.26929504
7Ribosome_Homo sapiens_hsa030103.10578325
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07789526
9Spliceosome_Homo sapiens_hsa030402.70931649
10Pyrimidine metabolism_Homo sapiens_hsa002402.62832679
11Nucleotide excision repair_Homo sapiens_hsa034202.58759336
12Fanconi anemia pathway_Homo sapiens_hsa034602.42344939
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39015673
14Non-homologous end-joining_Homo sapiens_hsa034502.32509256
15Phototransduction_Homo sapiens_hsa047442.17087899
16Selenocompound metabolism_Homo sapiens_hsa004502.12638616
17RNA transport_Homo sapiens_hsa030132.08970128
18Nitrogen metabolism_Homo sapiens_hsa009102.02644722
19RNA degradation_Homo sapiens_hsa030182.00542102
20Cell cycle_Homo sapiens_hsa041102.00303127
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90994526
22Basal transcription factors_Homo sapiens_hsa030221.88387828
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.85840270
24Butanoate metabolism_Homo sapiens_hsa006501.84950345
25Linoleic acid metabolism_Homo sapiens_hsa005911.77753212
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77490886
27Primary immunodeficiency_Homo sapiens_hsa053401.70544660
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69882021
29Tryptophan metabolism_Homo sapiens_hsa003801.67082690
30Purine metabolism_Homo sapiens_hsa002301.66853417
31* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62062440
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59361868
33* One carbon pool by folate_Homo sapiens_hsa006701.47272128
34Propanoate metabolism_Homo sapiens_hsa006401.40262974
35Protein export_Homo sapiens_hsa030601.40122005
36Sulfur metabolism_Homo sapiens_hsa009201.39265139
37p53 signaling pathway_Homo sapiens_hsa041151.35244852
38Caffeine metabolism_Homo sapiens_hsa002321.33013921
39Herpes simplex infection_Homo sapiens_hsa051681.25405079
40Ether lipid metabolism_Homo sapiens_hsa005651.22565315
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22086791
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19754895
43Cardiac muscle contraction_Homo sapiens_hsa042601.16229099
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15652078
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.09640764
46Epstein-Barr virus infection_Homo sapiens_hsa051691.09012474
47Sulfur relay system_Homo sapiens_hsa041221.07995481
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05002787
49Type I diabetes mellitus_Homo sapiens_hsa049401.03742170
50Oxidative phosphorylation_Homo sapiens_hsa001900.99800086
51Parkinsons disease_Homo sapiens_hsa050120.99593171
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.98788265
53Measles_Homo sapiens_hsa051620.98611505
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.98181633
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97300352
56Collecting duct acid secretion_Homo sapiens_hsa049660.95394207
57mRNA surveillance pathway_Homo sapiens_hsa030150.94093030
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92974708
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89794673
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88667596
61Nicotine addiction_Homo sapiens_hsa050330.88506640
62Huntingtons disease_Homo sapiens_hsa050160.88223997
63Chemical carcinogenesis_Homo sapiens_hsa052040.85765172
64Pentose phosphate pathway_Homo sapiens_hsa000300.85738970
65Allograft rejection_Homo sapiens_hsa053300.84690641
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84355217
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83169718
68Folate biosynthesis_Homo sapiens_hsa007900.81236612
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.78759140
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78378077
71Legionellosis_Homo sapiens_hsa051340.76047041
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75595266
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74164355
74Hematopoietic cell lineage_Homo sapiens_hsa046400.74075883
75Antigen processing and presentation_Homo sapiens_hsa046120.73343566
76Retinol metabolism_Homo sapiens_hsa008300.72862369
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71537842
78Vitamin B6 metabolism_Homo sapiens_hsa007500.70866734
79Olfactory transduction_Homo sapiens_hsa047400.70665447
80Taste transduction_Homo sapiens_hsa047420.66328974
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66185303
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.66025646
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64407516
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64405322
85Other glycan degradation_Homo sapiens_hsa005110.63105290
86Fatty acid elongation_Homo sapiens_hsa000620.62500314
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62049239
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61830109
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.61030565
90Systemic lupus erythematosus_Homo sapiens_hsa053220.59863469
91Influenza A_Homo sapiens_hsa051640.58827677
92beta-Alanine metabolism_Homo sapiens_hsa004100.58238708
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57144759
94Arachidonic acid metabolism_Homo sapiens_hsa005900.55093452
95Asthma_Homo sapiens_hsa053100.54923184
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54152104
97Leishmaniasis_Homo sapiens_hsa051400.53116010
98N-Glycan biosynthesis_Homo sapiens_hsa005100.52825052
99Autoimmune thyroid disease_Homo sapiens_hsa053200.52602332
100Fatty acid degradation_Homo sapiens_hsa000710.52336736
101Morphine addiction_Homo sapiens_hsa050320.50391715
102Steroid biosynthesis_Homo sapiens_hsa001000.49802138
103Rheumatoid arthritis_Homo sapiens_hsa053230.48608867
104Alzheimers disease_Homo sapiens_hsa050100.47294447
105Metabolic pathways_Homo sapiens_hsa011000.46340629
106ABC transporters_Homo sapiens_hsa020100.46174857
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45940606
108Vitamin digestion and absorption_Homo sapiens_hsa049770.45661118
109Pyruvate metabolism_Homo sapiens_hsa006200.44739975
110Regulation of autophagy_Homo sapiens_hsa041400.44035330
111Hepatitis B_Homo sapiens_hsa051610.43678786
112Apoptosis_Homo sapiens_hsa042100.43140224
113Mineral absorption_Homo sapiens_hsa049780.42196836
114HTLV-I infection_Homo sapiens_hsa051660.41751948
115Viral carcinogenesis_Homo sapiens_hsa052030.41148838
116Fatty acid metabolism_Homo sapiens_hsa012120.40995018
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40831511
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38862679
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38573991
120Glycerolipid metabolism_Homo sapiens_hsa005610.37422752
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35627320
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35603708
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35086027
124Serotonergic synapse_Homo sapiens_hsa047260.34033813
125Fat digestion and absorption_Homo sapiens_hsa049750.33589261
126Shigellosis_Homo sapiens_hsa051310.33493266
127B cell receptor signaling pathway_Homo sapiens_hsa046620.31894004
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.31363860
129Sphingolipid metabolism_Homo sapiens_hsa006000.30304019
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30100536
131Colorectal cancer_Homo sapiens_hsa052100.29647672
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27334055
133Graft-versus-host disease_Homo sapiens_hsa053320.24895568
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.23281579
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22903918
136Glutathione metabolism_Homo sapiens_hsa004800.21660542
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20114618
138Galactose metabolism_Homo sapiens_hsa000520.19090111
139Biosynthesis of amino acids_Homo sapiens_hsa012300.18428022
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.16121797
141Fructose and mannose metabolism_Homo sapiens_hsa000510.14509296
142T cell receptor signaling pathway_Homo sapiens_hsa046600.14288087
143Peroxisome_Homo sapiens_hsa041460.13850392
144Malaria_Homo sapiens_hsa051440.13188158
145Acute myeloid leukemia_Homo sapiens_hsa052210.13097460
146Hepatitis C_Homo sapiens_hsa051600.12714913
147Tuberculosis_Homo sapiens_hsa051520.11968669
148Pertussis_Homo sapiens_hsa051330.11203327

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