MTHFD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation (GO:0022616)5.82120683
2telomere maintenance via semi-conservative replication (GO:0032201)5.42443585
3L-phenylalanine metabolic process (GO:0006558)5.41377473
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.41377473
5glycine metabolic process (GO:0006544)5.40435864
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.37395320
7L-phenylalanine catabolic process (GO:0006559)5.37395320
8serine family amino acid biosynthetic process (GO:0009070)4.92088326
9cysteine metabolic process (GO:0006534)4.86716591
10nuclear pore complex assembly (GO:0051292)4.84601511
11aromatic amino acid family catabolic process (GO:0009074)4.79780583
12establishment of integrated proviral latency (GO:0075713)4.78994843
13mitotic chromosome condensation (GO:0007076)4.75882410
14DNA replication checkpoint (GO:0000076)4.74492372
15serine family amino acid catabolic process (GO:0009071)4.72821222
16serine family amino acid metabolic process (GO:0009069)4.67788804
17lysine metabolic process (GO:0006553)4.62931748
18lysine catabolic process (GO:0006554)4.62931748
19mitotic sister chromatid segregation (GO:0000070)4.61147492
20nuclear pore organization (GO:0006999)4.60979186
21telomere maintenance via recombination (GO:0000722)4.59819528
22glyoxylate metabolic process (GO:0046487)4.50729249
23kynurenine metabolic process (GO:0070189)4.44416108
24* folic acid-containing compound biosynthetic process (GO:0009396)4.37338235
25mitotic recombination (GO:0006312)4.34573642
26protein localization to kinetochore (GO:0034501)4.32740740
27tryptophan catabolic process (GO:0006569)4.30147644
28indole-containing compound catabolic process (GO:0042436)4.30147644
29indolalkylamine catabolic process (GO:0046218)4.30147644
30sister chromatid segregation (GO:0000819)4.25034904
31sulfur amino acid catabolic process (GO:0000098)4.25001678
32protein localization to chromosome, centromeric region (GO:0071459)4.23745913
33homocysteine metabolic process (GO:0050667)4.20472243
34mitotic metaphase plate congression (GO:0007080)4.19683131
35L-serine metabolic process (GO:0006563)4.18406532
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.15365259
37urea metabolic process (GO:0019627)4.12572124
38urea cycle (GO:0000050)4.12572124
39tryptophan metabolic process (GO:0006568)4.09419735
40bile acid biosynthetic process (GO:0006699)4.03634563
41mitotic sister chromatid cohesion (GO:0007064)4.03338473
42negative regulation of fibrinolysis (GO:0051918)3.96465251
43ribosome assembly (GO:0042255)3.94721909
44formation of translation preinitiation complex (GO:0001731)3.93696645
45alpha-linolenic acid metabolic process (GO:0036109)3.87502865
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.86082696
47* tetrahydrofolate metabolic process (GO:0046653)3.82930107
48nitrogen cycle metabolic process (GO:0071941)3.79981740
49mitotic nuclear envelope disassembly (GO:0007077)3.77114741
50telomere maintenance via telomere lengthening (GO:0010833)3.77109505
51alpha-amino acid catabolic process (GO:1901606)3.73935415
52regulation of protein activation cascade (GO:2000257)3.73010555
53nucleobase biosynthetic process (GO:0046112)3.69707020
54amino-acid betaine metabolic process (GO:0006577)3.68332225
55IMP metabolic process (GO:0046040)3.67770226
56* folic acid metabolic process (GO:0046655)3.66840086
57aromatic amino acid family metabolic process (GO:0009072)3.62173742
58pore complex assembly (GO:0046931)3.60996848
59DNA duplex unwinding (GO:0032508)3.59752079
60regulation of fibrinolysis (GO:0051917)3.59516934
61high-density lipoprotein particle remodeling (GO:0034375)3.59071541
62protein carboxylation (GO:0018214)3.58913637
63peptidyl-glutamic acid carboxylation (GO:0017187)3.58913637
64* one-carbon metabolic process (GO:0006730)3.58145637
65establishment of viral latency (GO:0019043)3.55481171
66CENP-A containing nucleosome assembly (GO:0034080)3.49642026
67chromatin remodeling at centromere (GO:0031055)3.49519163
68regulation of complement activation (GO:0030449)3.49511422
69metaphase plate congression (GO:0051310)3.48754536
70DNA geometric change (GO:0032392)3.47648827
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46689916
72bile acid metabolic process (GO:0008206)3.46502569
73negative regulation of sterol transport (GO:0032372)3.46478859
74negative regulation of cholesterol transport (GO:0032375)3.46478859
75* folic acid-containing compound metabolic process (GO:0006760)3.45864470
76nuclear envelope disassembly (GO:0051081)3.45147497
77membrane disassembly (GO:0030397)3.45147497
78cellular amino acid catabolic process (GO:0009063)3.44874620
79non-recombinational repair (GO:0000726)3.44729308
80double-strand break repair via nonhomologous end joining (GO:0006303)3.44729308
81complement activation, alternative pathway (GO:0006957)3.42196417
82purine nucleobase biosynthetic process (GO:0009113)3.41538489
83nucleobase-containing small molecule interconversion (GO:0015949)3.41403854
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40576821
85heterochromatin organization (GO:0070828)3.40387429
86ethanol oxidation (GO:0006069)3.39616904
87negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.39281720
88DNA unwinding involved in DNA replication (GO:0006268)3.36021117
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35583385
90aspartate family amino acid catabolic process (GO:0009068)3.32816727
91somatic diversification of immune receptors via somatic mutation (GO:0002566)3.30952214
92somatic hypermutation of immunoglobulin genes (GO:0016446)3.30952214
93ribosome biogenesis (GO:0042254)3.30888281
94positive regulation of chromosome segregation (GO:0051984)3.30385263
95DNA ligation (GO:0006266)3.30276507
96DNA topological change (GO:0006265)3.30188409
97cellular modified amino acid catabolic process (GO:0042219)3.26744444
98glutamate metabolic process (GO:0006536)3.25324518
99protein complex localization (GO:0031503)3.24968868
100* pteridine-containing compound biosynthetic process (GO:0042559)3.24940144
101tyrosine metabolic process (GO:0006570)3.20406414
102DNA replication-dependent nucleosome assembly (GO:0006335)3.18904107
103DNA replication-dependent nucleosome organization (GO:0034723)3.18904107
104IMP biosynthetic process (GO:0006188)3.17565891
105DNA conformation change (GO:0071103)3.17170282
106urate metabolic process (GO:0046415)3.16221418
107chromosome condensation (GO:0030261)3.15244914
108base-excision repair (GO:0006284)3.12983301
109telomere maintenance (GO:0000723)3.12019384
110regulation of centriole replication (GO:0046599)3.10105369
111telomere organization (GO:0032200)3.10050417
112negative regulation of mRNA processing (GO:0050686)3.08919399
113maturation of SSU-rRNA (GO:0030490)3.08857822
114* imidazole-containing compound metabolic process (GO:0052803)3.08657609
115dicarboxylic acid biosynthetic process (GO:0043650)3.06941274
116pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.06904820
117* pteridine-containing compound metabolic process (GO:0042558)3.06469108
118regulation of DNA endoreduplication (GO:0032875)3.06045528
119triglyceride homeostasis (GO:0070328)3.05373092
120acylglycerol homeostasis (GO:0055090)3.05373092
121reverse cholesterol transport (GO:0043691)3.04936980
122tRNA aminoacylation for protein translation (GO:0006418)3.04730861
1232-oxoglutarate metabolic process (GO:0006103)3.04166422
124macromolecular complex remodeling (GO:0034367)3.03254934
125plasma lipoprotein particle remodeling (GO:0034369)3.03254934
126protein-lipid complex remodeling (GO:0034368)3.03254934
127ribonucleoprotein complex biogenesis (GO:0022613)3.03158481
128DNA replication-independent nucleosome organization (GO:0034724)3.02483313
129DNA replication-independent nucleosome assembly (GO:0006336)3.02483313
130regulation of chromosome segregation (GO:0051983)3.01876895
131pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.01704368
132UMP biosynthetic process (GO:0006222)3.01704368
133pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.01704368
134UMP metabolic process (GO:0046049)3.01704368
135negative regulation of fatty acid biosynthetic process (GO:0045717)3.01650393
136regulation of cholesterol esterification (GO:0010872)3.01047933
137aldehyde catabolic process (GO:0046185)3.00916373
138tRNA aminoacylation (GO:0043039)3.00492997
139amino acid activation (GO:0043038)3.00492997
140regulation of mitochondrial translation (GO:0070129)3.00353477
141indolalkylamine metabolic process (GO:0006586)2.99335881
142regulation of cholesterol homeostasis (GO:2000188)2.99072085
143regulation of sister chromatid cohesion (GO:0007063)2.98305866
144bile acid and bile salt transport (GO:0015721)2.97790542
145DNA replication initiation (GO:0006270)2.97245059
146establishment of chromosome localization (GO:0051303)2.96755400
147response to nitrosative stress (GO:0051409)2.94835004
148regulation of triglyceride catabolic process (GO:0010896)2.94278695
149drug catabolic process (GO:0042737)2.94055202
150acetyl-CoA metabolic process (GO:0006084)2.93470744
151chromatin assembly or disassembly (GO:0006333)2.93343292
152negative regulation of chromosome segregation (GO:0051985)2.91755642
153DNA strand elongation involved in DNA replication (GO:0006271)2.91732614
154carboxylic acid catabolic process (GO:0046395)2.88039214
155organic acid catabolic process (GO:0016054)2.88039214
156benzene-containing compound metabolic process (GO:0042537)2.87827902
157glutamine family amino acid biosynthetic process (GO:0009084)2.87778713
158cellular glucuronidation (GO:0052695)2.87501002
159cell cycle G1/S phase transition (GO:0044843)2.87117616
160G1/S transition of mitotic cell cycle (GO:0000082)2.87117616
161regulation of translational termination (GO:0006449)2.87043429
162valine metabolic process (GO:0006573)2.86628030
163chromosome segregation (GO:0007059)2.86249976
164transcription-coupled nucleotide-excision repair (GO:0006283)2.85987360
165spindle checkpoint (GO:0031577)2.85981040
166blood coagulation, intrinsic pathway (GO:0007597)2.84094685
167plasma lipoprotein particle clearance (GO:0034381)2.83922203
168anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83816595
169* alpha-amino acid biosynthetic process (GO:1901607)2.83602433
170ribosomal small subunit biogenesis (GO:0042274)2.83122102
171regulation of translational fidelity (GO:0006450)2.82571933
172negative regulation of RNA splicing (GO:0033119)2.82321436
173proline biosynthetic process (GO:0006561)2.82257822
174drug metabolic process (GO:0017144)2.82154671
175negative regulation of mRNA metabolic process (GO:1903312)2.82038923
176regulation of centrosome cycle (GO:0046605)2.81932170
177cellular biogenic amine catabolic process (GO:0042402)2.80748075
178amine catabolic process (GO:0009310)2.80748075
179histone exchange (GO:0043486)2.80670553
180negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80654340
181peptidyl-arginine omega-N-methylation (GO:0035247)2.79876858
182DNA replication (GO:0006260)2.79141178
183spliceosomal tri-snRNP complex assembly (GO:0000244)2.78662418
184kinetochore organization (GO:0051383)2.78578104
185DNA packaging (GO:0006323)2.78002717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.77560260
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.71681048
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.77386948
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.56398027
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.51470419
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47186055
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.09370113
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.90503460
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.76276624
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.64943723
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.56126630
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.52373018
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41752378
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37878496
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32887994
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28608086
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17596455
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08721060
19* AR_21909140_ChIP-Seq_LNCAP_Human1.99457867
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97107826
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.94696869
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94670018
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93947119
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.89320762
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.88653970
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82413961
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81907001
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80203609
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78753716
30* XRN2_22483619_ChIP-Seq_HELA_Human1.75517195
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.67030044
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59878673
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58217764
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58205338
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54997481
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54119604
37* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52847514
38* E2F1_21310950_ChIP-Seq_MCF-7_Human1.49633132
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46225595
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46104453
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45315044
42ELK1_19687146_ChIP-ChIP_HELA_Human1.44841152
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44246252
44DCP1A_22483619_ChIP-Seq_HELA_Human1.44130598
45MYC_22102868_ChIP-Seq_BL_Human1.43292008
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43222990
47* GABP_19822575_ChIP-Seq_HepG2_Human1.39795789
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39474111
49FOXP3_21729870_ChIP-Seq_TREG_Human1.38369577
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38250522
51VDR_23849224_ChIP-Seq_CD4+_Human1.35506629
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33546117
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33183925
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.31074736
55KDM5A_27292631_Chip-Seq_BREAST_Human1.28953590
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26539911
57* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25431327
58* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24590259
59ZNF263_19887448_ChIP-Seq_K562_Human1.24502358
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22536009
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21523040
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17227827
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14424809
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14249986
65* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13681927
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13549206
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12394520
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11395734
69CLOCK_20551151_ChIP-Seq_293T_Human1.10284350
70* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07993582
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07899485
72TTF2_22483619_ChIP-Seq_HELA_Human1.06479731
73* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05093970
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04388994
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04084665
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03566685
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02479309
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.01006858
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00084706
80* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99932933
81OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99338316
82SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98314933
83GATA1_22025678_ChIP-Seq_K562_Human0.97388013
84SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97248473
85TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96409255
86CIITA_25753668_ChIP-Seq_RAJI_Human0.96279734
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95864842
88YY1_21170310_ChIP-Seq_MESCs_Mouse0.95405491
89TFEB_21752829_ChIP-Seq_HELA_Human0.95027958
90MYC_18940864_ChIP-ChIP_HL60_Human0.94525972
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.93459607
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92703837
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91938553
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91919296
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91609898
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89488906
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88685994
98CHD1_26751641_Chip-Seq_LNCaP_Human0.88240574
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88128255
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87774892
101* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86392753
102* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86087619
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86008819
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86008819
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86008819
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85373150
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85372396
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85266001
109HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85125754
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84838566
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84233834
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84225688
113TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84209822
114* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83567489
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81023787
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79619862
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.78410415
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77342802
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76024816
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73500153
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73167467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.58077416
2MP0005360_urolithiasis6.09622867
3MP0005085_abnormal_gallbladder_physiolo5.05404800
4MP0005365_abnormal_bile_salt4.74351092
5* MP0003806_abnormal_nucleotide_metabolis4.25240956
6MP0008875_abnormal_xenobiotic_pharmacok3.70036865
7MP0003252_abnormal_bile_duct2.98643650
8MP0009840_abnormal_foam_cell2.87168116
9MP0010329_abnormal_lipoprotein_level2.60838758
10MP0003693_abnormal_embryo_hatching2.53190884
11MP0005083_abnormal_biliary_tract2.49701741
12* MP0005332_abnormal_amino_acid2.34966703
13MP0004957_abnormal_blastocyst_morpholog2.34346823
14MP0010094_abnormal_chromosome_stability2.10497105
15MP0003111_abnormal_nucleus_morphology2.10173362
16MP0003195_calcinosis2.04549806
17MP0001666_abnormal_nutrient_absorption2.03311380
18MP0003705_abnormal_hypodermis_morpholog1.94922601
19MP0000609_abnormal_liver_physiology1.88499935
20MP0004019_abnormal_vitamin_homeostasis1.80143941
21MP0003186_abnormal_redox_activity1.79282352
22MP0003941_abnormal_skin_development1.74576941
23MP0004233_abnormal_muscle_weight1.73412688
24MP0003077_abnormal_cell_cycle1.72080510
25MP0004185_abnormal_adipocyte_glucose1.67000483
26MP0008057_abnormal_DNA_replication1.65157197
27MP0010352_gastrointestinal_tract_polyps1.60091927
28MP0002138_abnormal_hepatobiliary_system1.59301858
29MP0003191_abnormal_cellular_cholesterol1.58699236
30MP0001764_abnormal_homeostasis1.58545060
31* MP0005319_abnormal_enzyme/_coenzyme1.56587011
32MP0001730_embryonic_growth_arrest1.47598410
33MP0002118_abnormal_lipid_homeostasis1.43854594
34MP0003656_abnormal_erythrocyte_physiolo1.40236834
35MP0009643_abnormal_urine_homeostasis1.38901859
36MP0000598_abnormal_liver_morphology1.33304597
37MP0003868_abnormal_feces_composition1.31509745
38MP0001346_abnormal_lacrimal_gland1.28322974
39MP0006036_abnormal_mitochondrial_physio1.24817748
40MP0003718_maternal_effect1.24810490
41MP0008058_abnormal_DNA_repair1.18870905
42MP0005501_abnormal_skin_physiology1.15626287
43MP0005584_abnormal_enzyme/coenzyme_acti1.07163566
44MP0009053_abnormal_anal_canal1.06651800
45MP0003315_abnormal_perineum_morphology1.05935569
46MP0004264_abnormal_extraembryonic_tissu1.04225446
47MP0000350_abnormal_cell_proliferation1.03256270
48MP0001672_abnormal_embryogenesis/_devel1.02230605
49MP0005380_embryogenesis_phenotype1.02230605
50MP0002697_abnormal_eye_size1.02143763
51MP0010307_abnormal_tumor_latency1.01715280
52MP0000537_abnormal_urethra_morphology1.00770956
53MP0005220_abnormal_exocrine_pancreas0.98800999
54MP0001881_abnormal_mammary_gland0.98651335
55MP0009697_abnormal_copulation0.98401082
56MP0002796_impaired_skin_barrier0.97813626
57MP0009672_abnormal_birth_weight0.97143736
58MP0008932_abnormal_embryonic_tissue0.95576754
59MP0002086_abnormal_extraembryonic_tissu0.94443743
60MP0008007_abnormal_cellular_replicative0.93957718
61MP0003937_abnormal_limbs/digits/tail_de0.93817259
62* MP0002080_prenatal_lethality0.92894843
63MP0005636_abnormal_mineral_homeostasis0.92703505
64MP0006035_abnormal_mitochondrial_morpho0.91746931
65MP0001697_abnormal_embryo_size0.91720220
66MP0003984_embryonic_growth_retardation0.91535034
67MP0010030_abnormal_orbit_morphology0.91344763
68MP0002088_abnormal_embryonic_growth/wei0.91202745
69* MP0005266_abnormal_metabolism0.90247157
70MP0004197_abnormal_fetal_growth/weight/0.88818270
71MP0003890_abnormal_embryonic-extraembry0.82504756
72MP0004808_abnormal_hematopoietic_stem0.82023985
73MP0009763_increased_sensitivity_to0.81821342
74MP0005384_cellular_phenotype0.79533844
75MP0002210_abnormal_sex_determination0.79401477
76MP0001661_extended_life_span0.79230336
77MP0002163_abnormal_gland_morphology0.79059808
78MP0002009_preneoplasia0.76699922
79MP0005621_abnormal_cell_physiology0.76562376
80MP0010234_abnormal_vibrissa_follicle0.75196263
81MP0002160_abnormal_reproductive_system0.74587835
82MP0000627_abnormal_mammary_gland0.74290445
83MP0006054_spinal_hemorrhage0.73741986
84MP0002084_abnormal_developmental_patter0.73521373
85MP0002111_abnormal_tail_morphology0.73387183
86MP0009703_decreased_birth_body0.73091935
87MP0005647_abnormal_sex_gland0.72649310
88* MP0005376_homeostasis/metabolism_phenot0.71957745
89MP0002019_abnormal_tumor_incidence0.71525826
90MP0003123_paternal_imprinting0.71502330
91MP0005670_abnormal_white_adipose0.70638916
92MP0000579_abnormal_nail_morphology0.70219334
93MP0000358_abnormal_cell_content/0.70208320
94MP0002396_abnormal_hematopoietic_system0.70013025
95MP0002085_abnormal_embryonic_tissue0.70000892
96MP0005408_hypopigmentation0.69831943
97MP0001727_abnormal_embryo_implantation0.69735754
98MP0005330_cardiomyopathy0.69546083
99MP0005623_abnormal_meninges_morphology0.69248814
100MP0005023_abnormal_wound_healing0.68976848
101MP0001915_intracranial_hemorrhage0.68405157
102MP0001145_abnormal_male_reproductive0.68039960
103MP0005395_other_phenotype0.67079201
104MP0002970_abnormal_white_adipose0.66731891
105MP0001756_abnormal_urination0.66126377
106MP0002234_abnormal_pharynx_morphology0.66005702
107MP0006292_abnormal_olfactory_placode0.65878805
108MP0005451_abnormal_body_composition0.65748847
109MP0004782_abnormal_surfactant_physiolog0.65671290
110MP0002938_white_spotting0.65388936
111MP0009642_abnormal_blood_homeostasis0.64741940
112MP0001849_ear_inflammation0.64396233
113MP0003119_abnormal_digestive_system0.63694908
114MP0001929_abnormal_gametogenesis0.63660517
115MP0005076_abnormal_cell_differentiation0.63376999
116MP0002060_abnormal_skin_morphology0.62662509
117MP0003221_abnormal_cardiomyocyte_apopto0.61552604
118MP0004043_abnormal_pH_regulation0.61389124
119MP0001286_abnormal_eye_development0.61247486
120MP0009765_abnormal_xenobiotic_induced0.61186254
121MP0004133_heterotaxia0.60094712
122MP0003943_abnormal_hepatobiliary_system0.60073675
123MP0003786_premature_aging0.59746827
124MP0002269_muscular_atrophy0.59096170
125MP0003011_delayed_dark_adaptation0.59091057
126MP0002078_abnormal_glucose_homeostasis0.58540106
127MP0008877_abnormal_DNA_methylation0.58221099
128MP0000490_abnormal_crypts_of0.57777816
129MP0008469_abnormal_protein_level0.57384107
130MP0000313_abnormal_cell_death0.57303136
131MP0002136_abnormal_kidney_physiology0.56734975
132MP0000653_abnormal_sex_gland0.56575968
133MP0008873_increased_physiological_sensi0.55981150
134MP0001293_anophthalmia0.55194726
135MP0003567_abnormal_fetal_cardiomyocyte0.54076886
136MP0003283_abnormal_digestive_organ0.51355001
137MP0005666_abnormal_adipose_tissue0.50924613
138MP0000477_abnormal_intestine_morphology0.49251898
139MP0003566_abnormal_cell_adhesion0.49165144
140MP0002877_abnormal_melanocyte_morpholog0.49102540

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.20751076
2Abnormality of monocarboxylic acid metabolism (HP:0010996)6.20508376
3Chromosomal breakage induced by crosslinking agents (HP:0003221)6.05450492
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.83312886
5Chromsome breakage (HP:0040012)5.73267908
6Hypobetalipoproteinemia (HP:0003563)5.58292842
7Deep venous thrombosis (HP:0002625)5.32468862
8Xanthomatosis (HP:0000991)4.74794932
9Abnormality of pyrimidine metabolism (HP:0004353)4.69333135
10Hyperglycinemia (HP:0002154)4.39526911
11Prolonged partial thromboplastin time (HP:0003645)4.34608372
12Hyperammonemia (HP:0001987)4.28337028
13Abnormality of sulfur amino acid metabolism (HP:0004339)4.20886315
14Hyperglycinuria (HP:0003108)4.09166102
15Abnormality of methionine metabolism (HP:0010901)3.95980447
16Hypolipoproteinemia (HP:0010981)3.95749658
17Abnormality of serine family amino acid metabolism (HP:0010894)3.94926664
18Abnormality of glycine metabolism (HP:0010895)3.94926664
19Hypoglycemic coma (HP:0001325)3.94702700
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.79462684
21Ketosis (HP:0001946)3.66703978
22Hyperlipoproteinemia (HP:0010980)3.58028987
23Abnormality of glycolysis (HP:0004366)3.55385238
24Abnormality of the preputium (HP:0100587)3.55096740
25Spastic diplegia (HP:0001264)3.54549164
26Meckel diverticulum (HP:0002245)3.48078203
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.41689823
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.37954479
29Complement deficiency (HP:0004431)3.37549423
30Abnormality of the common coagulation pathway (HP:0010990)3.32201642
31Abnormality of nucleobase metabolism (HP:0010932)3.28572130
32Abnormality of the ileum (HP:0001549)3.27793358
33Abnormality of chromosome stability (HP:0003220)3.26129518
34Microvesicular hepatic steatosis (HP:0001414)3.24419934
35Increased serum pyruvate (HP:0003542)3.22224206
36Epidermoid cyst (HP:0200040)3.21937009
37Aplasia/Hypoplasia of the uvula (HP:0010293)3.20893285
38Fat malabsorption (HP:0002630)3.20293264
39Abnormality of serum amino acid levels (HP:0003112)3.16796943
40Increased nuchal translucency (HP:0010880)3.11387269
41Hypoalphalipoproteinemia (HP:0003233)3.09922203
42Hyperbilirubinemia (HP:0002904)3.07225679
43Abnormality of the intrinsic pathway (HP:0010989)3.05742963
44Progressive muscle weakness (HP:0003323)2.98233536
45Gout (HP:0001997)2.95642921
46Delayed CNS myelination (HP:0002188)2.94191548
47Joint hemorrhage (HP:0005261)2.93501199
48Ketoacidosis (HP:0001993)2.79393815
49Abnormality of fatty-acid metabolism (HP:0004359)2.79067837
50Hepatocellular carcinoma (HP:0001402)2.72947620
51Abnormality of the carotid arteries (HP:0005344)2.67954215
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.63350064
53Abnormality of complement system (HP:0005339)2.62059597
54Small intestinal stenosis (HP:0012848)2.61043777
55Duodenal stenosis (HP:0100867)2.61043777
56Oral leukoplakia (HP:0002745)2.59968959
57Abnormality of purine metabolism (HP:0004352)2.58191627
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54001537
59Dicarboxylic aciduria (HP:0003215)2.54001537
60Hypoglycemic seizures (HP:0002173)2.50693964
61Lethargy (HP:0001254)2.50609115
62Selective tooth agenesis (HP:0001592)2.50078878
63Ependymoma (HP:0002888)2.43284476
64Conjugated hyperbilirubinemia (HP:0002908)2.41228853
65Trismus (HP:0000211)2.41025691
66Megaloblastic anemia (HP:0001889)2.39992397
67Reduced antithrombin III activity (HP:0001976)2.39415517
68Proximal placement of thumb (HP:0009623)2.38874961
69Hypercholesterolemia (HP:0003124)2.38082246
70Myelodysplasia (HP:0002863)2.37618914
71Metabolic acidosis (HP:0001942)2.36011562
72Hypochromic microcytic anemia (HP:0004840)2.35498873
73Nephroblastoma (Wilms tumor) (HP:0002667)2.33565741
74Steatorrhea (HP:0002570)2.32443288
75Late onset (HP:0003584)2.32348989
76Acanthocytosis (HP:0001927)2.31923751
77Hyperinsulinemic hypoglycemia (HP:0000825)2.31801147
78Deviation of the thumb (HP:0009603)2.29453101
79Reticulocytosis (HP:0001923)2.29164988
80Abnormal cartilage morphology (HP:0002763)2.26349724
81Absent radius (HP:0003974)2.25909574
82Abnormality of transition element cation homeostasis (HP:0011030)2.22148135
83Malnutrition (HP:0004395)2.19601234
84Abnormality of the duodenum (HP:0002246)2.18257061
85Squamous cell carcinoma (HP:0002860)2.18253229
86Irritability (HP:0000737)2.18045721
87Generalized aminoaciduria (HP:0002909)2.16963531
88Poikilocytosis (HP:0004447)2.14832061
89Hyperacusis (HP:0010780)2.14507089
90Abnormality of iron homeostasis (HP:0011031)2.14198984
91Embryonal renal neoplasm (HP:0011794)2.13702013
92Horseshoe kidney (HP:0000085)2.12065936
93Ectopic kidney (HP:0000086)2.10943422
94Multiple enchondromatosis (HP:0005701)2.10709378
95Ragged-red muscle fibers (HP:0003200)2.10581292
96Cerebral edema (HP:0002181)2.10208231
97Aplasia involving forearm bones (HP:0009822)2.10047799
98Absent forearm bone (HP:0003953)2.10047799
99Abnormality of the heme biosynthetic pathway (HP:0010472)2.08404653
100Choanal atresia (HP:0000453)2.08078635
101Rhabdomyosarcoma (HP:0002859)2.07885642
102Cafe-au-lait spot (HP:0000957)2.06975081
103Birth length less than 3rd percentile (HP:0003561)2.06485194
104High pitched voice (HP:0001620)2.05915071
105Abnormality of reticulocytes (HP:0004312)2.05816145
106Absent thumb (HP:0009777)2.04718925
107Neonatal onset (HP:0003623)2.03844056
108Colon cancer (HP:0003003)2.02766110
109Abnormality of the umbilical cord (HP:0010881)2.02736477
110Pancytopenia (HP:0001876)2.01291121
111Progressive external ophthalmoplegia (HP:0000590)2.00164046
112Skin nodule (HP:0200036)1.99935294
113Pseudobulbar signs (HP:0002200)1.98819119
114Abnormality of cochlea (HP:0000375)1.98465822
115Abnormality of cells of the erythroid lineage (HP:0012130)1.97115999
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96086741
117Volvulus (HP:0002580)1.94426211
118Increased purine levels (HP:0004368)1.93397650
119Hyperuricemia (HP:0002149)1.93397650
120Cholelithiasis (HP:0001081)1.93340009
121Esophageal varix (HP:0002040)1.93326300
122Abnormal gallbladder morphology (HP:0012437)1.92255319
123Cortical dysplasia (HP:0002539)1.91037410
124Insomnia (HP:0100785)1.90194616
125Abnormal lung lobation (HP:0002101)1.89831739
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89617400
127Septate vagina (HP:0001153)1.89050313
128Atresia of the external auditory canal (HP:0000413)1.88908989
129Increased serum ferritin (HP:0003281)1.88355593
130Sloping forehead (HP:0000340)1.88284186
131Triphalangeal thumb (HP:0001199)1.88245551
132Increased serum lactate (HP:0002151)1.87524724
133Clubbing of toes (HP:0100760)1.87368778
134Overlapping toe (HP:0001845)1.85651419
135Nausea (HP:0002018)1.85191605
136Abnormality of the pancreatic islet cells (HP:0006476)1.84942235
137Abnormality of endocrine pancreas physiology (HP:0012093)1.84942235
138Microglossia (HP:0000171)1.83469497
139Abnormal number of erythroid precursors (HP:0012131)1.81342996
140Overriding aorta (HP:0002623)1.81120756
141Macrocytic anemia (HP:0001972)1.80953777
142Abnormality of the labia minora (HP:0012880)1.80803554
143Abnormal enzyme/coenzyme activity (HP:0012379)1.78934065
144Patellar aplasia (HP:0006443)1.78823663
145Brushfield spots (HP:0001088)1.77988820
146Back pain (HP:0003418)1.77004139
147Vomiting (HP:0002013)1.76500630
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76436947
149Abnormality of alanine metabolism (HP:0010916)1.76436947
150Hyperalaninemia (HP:0003348)1.76436947
151Opisthotonus (HP:0002179)1.76068456
152Type I transferrin isoform profile (HP:0003642)1.75967292
153Poikiloderma (HP:0001029)1.75685560
154Short thumb (HP:0009778)1.75607461
155Glioma (HP:0009733)1.74210667
156Facial cleft (HP:0002006)1.72963751
157Proximal tubulopathy (HP:0000114)1.72866355
158Abnormality of subcutaneous fat tissue (HP:0001001)1.71416218
159Impulsivity (HP:0100710)1.71290172
160Arteriovenous malformation (HP:0100026)1.70100809
161Abnormality of the astrocytes (HP:0100707)1.69981552
162Astrocytoma (HP:0009592)1.69981552
163Medulloblastoma (HP:0002885)1.68982675
164Myocardial infarction (HP:0001658)1.68426132
165Vascular calcification (HP:0004934)1.66621958
166Abnormal gallbladder physiology (HP:0012438)1.65165310
167Cholecystitis (HP:0001082)1.65165310
168Breast hypoplasia (HP:0003187)1.65132264
169Hyperglycemia (HP:0003074)1.64804530
170Reticulocytopenia (HP:0001896)1.64307091
171Spontaneous abortion (HP:0005268)1.62776449
172Rhabdomyolysis (HP:0003201)1.62468642
173Limb hypertonia (HP:0002509)1.62309927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.06147727
2WEE13.39174463
3CDC73.22024477
4VRK23.21565813
5BUB13.11147334
6NEK12.93806457
7SMG12.83052525
8PBK2.58420547
9EIF2AK12.45008826
10PKN22.43757489
11EPHA22.32254378
12FLT32.32041717
13TTK2.22154157
14PASK2.20336015
15EEF2K2.16293861
16NEK22.14992917
17TSSK62.06290341
18TAF11.99635628
19SCYL21.92659337
20CDK121.89659659
21RPS6KB21.86027007
22ZAK1.81921976
23MAP3K101.73505867
24TRIB31.66316425
25CDK81.62833397
26FGFR41.62355254
27SIK11.59434741
28CDK41.58549823
29TESK21.57653944
30ACVR1B1.57366087
31ERN11.55757803
32NME21.55094771
33MAP3K81.53842598
34PLK11.44246698
35CDK71.42438574
36BRSK21.39129149
37MST1R1.33829142
38STK101.31665103
39AURKB1.29563355
40EIF2AK31.25434405
41ERBB41.23814496
42ATR1.22670663
43KDR1.17717589
44NME11.15419292
45AURKA1.13679417
46SRPK11.11220360
47TGFBR11.08012111
48MKNK21.06632190
49MAPK111.06365430
50MAP2K31.06217866
51DYRK31.05682706
52EIF2AK21.05219372
53TLK11.04955548
54CDK61.04777668
55IRAK31.04069928
56RPS6KA41.00522007
57PAK41.00289435
58CHEK10.98551129
59LRRK20.96511669
60MTOR0.94307385
61MAP3K110.90762040
62CHEK20.89515900
63PTK60.88871757
64STK38L0.88828594
65VRK10.84586403
66MET0.84308454
67MAPKAPK30.84144530
68GRK60.84114291
69MAP3K30.82418543
70MST40.82182429
71PNCK0.81402020
72STK40.80877681
73LATS10.80831125
74CCNB10.79217859
75PLK40.77884048
76PLK30.76795867
77STK160.76447930
78PIM10.75780617
79DAPK10.75502705
80ALK0.75162271
81CDK20.72328461
82CSNK2A20.71676851
83ATM0.68331009
84CDK90.67758277
85PDK40.67629826
86PDK30.67629826
87TAOK30.65938345
88BRSK10.65670586
89NUAK10.64976583
90CLK10.61741574
91TAOK20.58069669
92CSNK1E0.57338645
93BRD40.57162032
94AKT20.54421225
95PRKCI0.54111379
96ABL20.53809075
97MAPKAPK50.52759738
98CSNK2A10.52495680
99TYK20.49016215
100MAP3K90.44174326
101CDK10.43483639
102BRAF0.42177651
103JAK20.41621610
104FGFR10.41080205
105MAP4K10.40779952
106PAK20.40520663
107INSRR0.39495156
108PDK20.39280881
109CDK150.39114250
110MAP2K20.38875040
111CDK11A0.38456832
112STK30.38169284
113CDK180.37668028
114WNK30.36963565
115TTN0.36391595
116MELK0.36204181
117LATS20.35606329
118CSNK1D0.34662877
119NEK90.33354016
120ERBB20.32304605
121PRKDC0.31238112
122MAPK140.31025733
123CDK140.30241175
124MAP3K50.29783544
125MKNK10.29490071
126PAK10.29062324
127GSK3A0.28870893
128ICK0.28825625
129ILK0.24793569
130TRIM280.23837393
131PTK20.22192148

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.26179364
2Nitrogen metabolism_Homo sapiens_hsa009102.95285001
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92608756
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90602292
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64797729
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.59223165
7Arginine biosynthesis_Homo sapiens_hsa002202.45820491
8* One carbon pool by folate_Homo sapiens_hsa006702.32107726
9Selenocompound metabolism_Homo sapiens_hsa004502.31209566
10Tryptophan metabolism_Homo sapiens_hsa003802.19844118
11Fatty acid degradation_Homo sapiens_hsa000712.07539549
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07059801
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06381522
14DNA replication_Homo sapiens_hsa030302.04268570
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.02699252
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.91079249
17Biosynthesis of amino acids_Homo sapiens_hsa012301.87177298
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.85644554
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.80560670
20Complement and coagulation cascades_Homo sapiens_hsa046101.77098560
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76130403
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.73560619
23Folate biosynthesis_Homo sapiens_hsa007901.71905972
24Mismatch repair_Homo sapiens_hsa034301.69059593
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67122315
26Propanoate metabolism_Homo sapiens_hsa006401.62692898
27Peroxisome_Homo sapiens_hsa041461.59607884
28Butanoate metabolism_Homo sapiens_hsa006501.59448591
29Carbon metabolism_Homo sapiens_hsa012001.58000692
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54660162
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50389996
32Pyruvate metabolism_Homo sapiens_hsa006201.42239442
33beta-Alanine metabolism_Homo sapiens_hsa004101.40041289
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39477966
35Chemical carcinogenesis_Homo sapiens_hsa052041.39471742
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38516705
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37419311
38Fatty acid metabolism_Homo sapiens_hsa012121.36191181
39Histidine metabolism_Homo sapiens_hsa003401.33576851
40Sulfur relay system_Homo sapiens_hsa041221.31885865
41Phenylalanine metabolism_Homo sapiens_hsa003601.24622335
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22067787
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.20819626
44PPAR signaling pathway_Homo sapiens_hsa033201.20112298
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19522361
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.18741616
47Retinol metabolism_Homo sapiens_hsa008301.17349985
48Caffeine metabolism_Homo sapiens_hsa002321.16194572
49Pentose phosphate pathway_Homo sapiens_hsa000301.13444566
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11387687
51RNA transport_Homo sapiens_hsa030131.10269399
52Arginine and proline metabolism_Homo sapiens_hsa003301.09169189
53Tyrosine metabolism_Homo sapiens_hsa003501.05887200
54Pyrimidine metabolism_Homo sapiens_hsa002401.04159820
55Starch and sucrose metabolism_Homo sapiens_hsa005000.99616253
56Bile secretion_Homo sapiens_hsa049760.99124966
57Vitamin B6 metabolism_Homo sapiens_hsa007500.97342894
58Sulfur metabolism_Homo sapiens_hsa009200.96803896
59Spliceosome_Homo sapiens_hsa030400.96116040
60Fat digestion and absorption_Homo sapiens_hsa049750.94499185
61Glutathione metabolism_Homo sapiens_hsa004800.94187171
62Lysine degradation_Homo sapiens_hsa003100.94113188
63Base excision repair_Homo sapiens_hsa034100.94102330
64Nucleotide excision repair_Homo sapiens_hsa034200.93107798
65Basal transcription factors_Homo sapiens_hsa030220.90929215
66Proteasome_Homo sapiens_hsa030500.85566097
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83754483
68Ribosome_Homo sapiens_hsa030100.83409077
69Staphylococcus aureus infection_Homo sapiens_hsa051500.80771534
70ABC transporters_Homo sapiens_hsa020100.78124249
71Vitamin digestion and absorption_Homo sapiens_hsa049770.75814294
72RNA polymerase_Homo sapiens_hsa030200.75283642
73Homologous recombination_Homo sapiens_hsa034400.72680629
74Oocyte meiosis_Homo sapiens_hsa041140.70504004
75Fatty acid elongation_Homo sapiens_hsa000620.66299132
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65035384
77Cell cycle_Homo sapiens_hsa041100.64766236
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64742919
79N-Glycan biosynthesis_Homo sapiens_hsa005100.60711577
80Fructose and mannose metabolism_Homo sapiens_hsa000510.60474843
81Steroid biosynthesis_Homo sapiens_hsa001000.60252557
82Systemic lupus erythematosus_Homo sapiens_hsa053220.57917082
83Protein export_Homo sapiens_hsa030600.55463018
84Thyroid cancer_Homo sapiens_hsa052160.54714667
85Parkinsons disease_Homo sapiens_hsa050120.53414622
86* Metabolic pathways_Homo sapiens_hsa011000.53047933
87Galactose metabolism_Homo sapiens_hsa000520.52752235
88Non-homologous end-joining_Homo sapiens_hsa034500.49918673
89Huntingtons disease_Homo sapiens_hsa050160.49459489
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46990255
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44102437
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43369197
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41515117
94Glycerolipid metabolism_Homo sapiens_hsa005610.39535781
95Oxidative phosphorylation_Homo sapiens_hsa001900.39244157
96RNA degradation_Homo sapiens_hsa030180.37328687
97Epstein-Barr virus infection_Homo sapiens_hsa051690.33092824
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32722641
99Fanconi anemia pathway_Homo sapiens_hsa034600.32174283
100p53 signaling pathway_Homo sapiens_hsa041150.32106257
101MicroRNAs in cancer_Homo sapiens_hsa052060.30073742
102Purine metabolism_Homo sapiens_hsa002300.29146922
103Fatty acid biosynthesis_Homo sapiens_hsa000610.27800144
104mRNA surveillance pathway_Homo sapiens_hsa030150.22469960
105Small cell lung cancer_Homo sapiens_hsa052220.18153088
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16576239
107Alzheimers disease_Homo sapiens_hsa050100.14093175
108HTLV-I infection_Homo sapiens_hsa051660.13527632
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.13438891
110Glucagon signaling pathway_Homo sapiens_hsa049220.12738914
111Insulin resistance_Homo sapiens_hsa049310.11715491
112Viral carcinogenesis_Homo sapiens_hsa052030.11293184
113Bladder cancer_Homo sapiens_hsa052190.10328207
114Prion diseases_Homo sapiens_hsa050200.10029050
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09923435
116AMPK signaling pathway_Homo sapiens_hsa041520.07071867

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