MTHFD1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)6.98505609
2L-serine metabolic process (GO:0006563)6.13121330
3regulation of plasminogen activation (GO:0010755)5.93673284
4DNA unwinding involved in DNA replication (GO:0006268)5.89104536
5protein localization to kinetochore (GO:0034501)5.12707379
6cellular protein complex localization (GO:0034629)5.02060284
7nuclear pore organization (GO:0006999)4.96636306
8nuclear pore complex assembly (GO:0051292)4.89555082
9DNA strand elongation involved in DNA replication (GO:0006271)4.61472764
10DNA replication initiation (GO:0006270)4.58308726
11serine family amino acid biosynthetic process (GO:0009070)4.54266571
12protein complex localization (GO:0031503)4.53741435
13desmosome organization (GO:0002934)4.51385940
14* folic acid-containing compound biosynthetic process (GO:0009396)4.43990390
15mitochondrial RNA metabolic process (GO:0000959)4.41229868
16IMP biosynthetic process (GO:0006188)4.39655687
17DNA strand elongation (GO:0022616)4.38535572
18mitotic nuclear envelope disassembly (GO:0007077)4.36645824
19epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.30841991
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.29003582
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.29003582
22cysteine metabolic process (GO:0006534)4.26423634
23negative regulation of DNA biosynthetic process (GO:2000279)4.21627262
24sulfur amino acid catabolic process (GO:0000098)4.21222347
25protein localization to chromosome, centromeric region (GO:0071459)4.15419291
26regulation of translational fidelity (GO:0006450)4.13782576
27telomere maintenance via semi-conservative replication (GO:0032201)4.10150902
28nuclear envelope disassembly (GO:0051081)4.06820406
29membrane disassembly (GO:0030397)4.06820406
30DNA duplex unwinding (GO:0032508)4.04645779
31DNA geometric change (GO:0032392)4.01934299
32white fat cell differentiation (GO:0050872)4.00282603
33purine nucleotide salvage (GO:0032261)3.99595955
34formation of translation preinitiation complex (GO:0001731)3.97623035
35IMP metabolic process (GO:0046040)3.90169336
36chromosome condensation (GO:0030261)3.87880114
37cell migration involved in heart development (GO:0060973)3.87787831
38folic acid metabolic process (GO:0046655)3.85113779
39DNA replication-dependent nucleosome assembly (GO:0006335)3.77014444
40DNA replication-dependent nucleosome organization (GO:0034723)3.77014444
41maturation of SSU-rRNA (GO:0030490)3.75760183
42microtubule nucleation (GO:0007020)3.72445005
43nucleobase biosynthetic process (GO:0046112)3.71226225
44ribosomal small subunit assembly (GO:0000028)3.71222451
45pore complex assembly (GO:0046931)3.68954824
46mitotic sister chromatid segregation (GO:0000070)3.68792928
47sister chromatid segregation (GO:0000819)3.65304650
48viral transcription (GO:0019083)3.64869262
49telomere maintenance via recombination (GO:0000722)3.63777081
50translational termination (GO:0006415)3.61907934
51mitotic recombination (GO:0006312)3.61568758
52regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.50062133
53COPII vesicle coating (GO:0048208)3.49146104
54regulation of histone H3-K9 methylation (GO:0051570)3.48874905
55heterochromatin organization (GO:0070828)3.48761688
56negative regulation of keratinocyte proliferation (GO:0010839)3.46469250
57negative regulation of telomerase activity (GO:0051974)3.42600339
58mitotic chromosome condensation (GO:0007076)3.42068298
59DNA replication checkpoint (GO:0000076)3.41125874
60telomere maintenance via telomere lengthening (GO:0010833)3.34733976
61translational elongation (GO:0006414)3.34203122
62dosage compensation (GO:0007549)3.32428935
63translational initiation (GO:0006413)3.31025572
64translesion synthesis (GO:0019985)3.30947775
65inner ear receptor cell development (GO:0060119)3.29295407
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28771663
67negative regulation of catenin import into nucleus (GO:0035414)3.28523554
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.28337566
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27529851
70regulation of tight junction assembly (GO:2000810)3.26705327
71negative regulation of histone methylation (GO:0031061)3.23751980
72regulation of translational termination (GO:0006449)3.23410699
73regulation of gonadotropin secretion (GO:0032276)3.23087581
74chromatin assembly (GO:0031497)3.21906795
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21675057
76DNA packaging (GO:0006323)3.21491888
77mitotic metaphase plate congression (GO:0007080)3.20825147
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20757783
79nuclear envelope organization (GO:0006998)3.19355848
80positive regulation of chromosome segregation (GO:0051984)3.18452791
81rRNA methylation (GO:0031167)3.17801265
82mitotic sister chromatid cohesion (GO:0007064)3.17418244
83negative regulation of RNA splicing (GO:0033119)3.17072700
84pre-miRNA processing (GO:0031054)3.14458728
85pseudouridine synthesis (GO:0001522)3.13330158
86negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.12923577
87ribosomal small subunit biogenesis (GO:0042274)3.11796835
88ribosomal large subunit biogenesis (GO:0042273)3.11550977
89DNA conformation change (GO:0071103)3.10754376
90regulation of vitamin D biosynthetic process (GO:0060556)3.10704323
91ribosome biogenesis (GO:0042254)3.08580323
92negative regulation of chondrocyte differentiation (GO:0032331)3.07710090
93ribosome assembly (GO:0042255)3.06617749
94viral mRNA export from host cell nucleus (GO:0046784)3.05900904
95ribonucleoprotein complex biogenesis (GO:0022613)3.05406865
96regulation of spindle organization (GO:0090224)3.03262917
97SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.03029850
98rRNA modification (GO:0000154)3.02745134
99postreplication repair (GO:0006301)2.98555046
100protein localization to chromosome (GO:0034502)2.98044726
101somatic hypermutation of immunoglobulin genes (GO:0016446)2.97698679
102somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97698679
103protein targeting to ER (GO:0045047)2.94917351
104regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94489771
105chromatin assembly or disassembly (GO:0006333)2.93943314
106cotranslational protein targeting to membrane (GO:0006613)2.93450789
107transcription from mitochondrial promoter (GO:0006390)2.93288843
108purine nucleobase biosynthetic process (GO:0009113)2.92018683
109establishment of integrated proviral latency (GO:0075713)2.90069374
110response to vitamin A (GO:0033189)2.89832217
111metaphase plate congression (GO:0051310)2.89488312
112cellular protein complex disassembly (GO:0043624)2.88924535
113histone exchange (GO:0043486)2.88324020
114mitochondrial DNA metabolic process (GO:0032042)2.88135236
115cartilage morphogenesis (GO:0060536)2.87726858
116DNA ligation (GO:0006266)2.86514378
117histone arginine methylation (GO:0034969)2.86435103
118tRNA modification (GO:0006400)2.86354798
119negative regulation of mRNA processing (GO:0050686)2.84881812
120establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83032836
121peptidyl-arginine omega-N-methylation (GO:0035247)2.82777046
122ATP-dependent chromatin remodeling (GO:0043044)2.82715206
123alternative mRNA splicing, via spliceosome (GO:0000380)2.82518737
124telomere maintenance (GO:0000723)2.81274896
125chromatin remodeling at centromere (GO:0031055)2.80901175
126viral life cycle (GO:0019058)2.80865041
127peptidyl-proline hydroxylation (GO:0019511)2.80311375
128nucleotide salvage (GO:0043173)2.79962932
129telomere organization (GO:0032200)2.79470145
130regulation of RNA export from nucleus (GO:0046831)2.79065693
131rRNA processing (GO:0006364)2.77691763
132spliceosomal tri-snRNP complex assembly (GO:0000244)2.77240215
133protein complex disassembly (GO:0043241)2.77069091
134DNA replication-independent nucleosome organization (GO:0034724)2.76599846
135DNA replication-independent nucleosome assembly (GO:0006336)2.76599846
136regulation of centrosome cycle (GO:0046605)2.76599747
137negative regulation of mRNA metabolic process (GO:1903312)2.76441273
138regulation of posttranscriptional gene silencing (GO:0060147)2.75582039
139regulation of gene silencing by miRNA (GO:0060964)2.75582039
140regulation of gene silencing by RNA (GO:0060966)2.75582039
141histone H4-K12 acetylation (GO:0043983)2.75111219
142CENP-A containing nucleosome assembly (GO:0034080)2.75099799
143attachment of spindle microtubules to kinetochore (GO:0008608)2.74976525
144RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.74307038
145mRNA splicing, via spliceosome (GO:0000398)2.74307038
146RNA splicing, via transesterification reactions (GO:0000375)2.73736664
147regulation of mitotic spindle organization (GO:0060236)2.73512174
148base-excision repair (GO:0006284)2.73344567
149sulfur amino acid biosynthetic process (GO:0000097)2.72474783
150negative regulation of cell size (GO:0045792)2.70344335
151galactose catabolic process (GO:0019388)2.68686723
152negative regulation of stem cell proliferation (GO:2000647)2.66933864
153peptidyl-arginine methylation (GO:0018216)2.65939518
154peptidyl-arginine N-methylation (GO:0035246)2.65939518
155* folic acid-containing compound metabolic process (GO:0006760)2.62937897
156double-strand break repair via nonhomologous end joining (GO:0006303)2.61760261
157non-recombinational repair (GO:0000726)2.61760261
158pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.61236676
159adenosine metabolic process (GO:0046085)2.60517664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.90484958
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.47303822
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.39818710
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.98242225
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.76219820
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65794831
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.07405297
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93231994
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92182000
10MYC_22102868_ChIP-Seq_BL_Human2.65365443
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56654557
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35040484
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15743876
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.14988354
15ZNF263_19887448_ChIP-Seq_K562_Human2.14961510
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.13258366
17* XRN2_22483619_ChIP-Seq_HELA_Human2.11766647
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06537992
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.99575690
20AR_21909140_ChIP-Seq_LNCAP_Human1.99526621
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.96250341
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93094043
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82285243
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.81063306
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80947171
26VDR_23849224_ChIP-Seq_CD4+_Human1.76706090
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75741398
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74419040
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72012693
30FOXP3_21729870_ChIP-Seq_TREG_Human1.70236970
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68919313
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68085052
33CIITA_25753668_ChIP-Seq_RAJI_Human1.67749635
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67142598
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66836577
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65375285
37VDR_21846776_ChIP-Seq_THP-1_Human1.64472528
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63000149
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57794202
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57391460
41TTF2_22483619_ChIP-Seq_HELA_Human1.57210684
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56535005
43DCP1A_22483619_ChIP-Seq_HELA_Human1.52116088
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51518391
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49847085
46GABP_19822575_ChIP-Seq_HepG2_Human1.49623589
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48903112
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48591686
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47469400
50* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46837894
51ELK1_19687146_ChIP-ChIP_HELA_Human1.45484333
52KDM5A_27292631_Chip-Seq_BREAST_Human1.45329453
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42064664
54SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.41658057
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38588635
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38194738
57TFEB_21752829_ChIP-Seq_HELA_Human1.36239389
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34472365
59* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32039351
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30137921
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28964747
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28822843
63* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27612348
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25956859
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25233228
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24936052
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24921032
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23894938
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23271488
70TBX5_21415370_ChIP-Seq_HL-1_Mouse1.21709256
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21592318
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.19933461
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17810848
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17477232
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16926937
76* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16647511
77* ATF3_27146783_Chip-Seq_COLON_Human1.16641137
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15524481
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15469228
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14717104
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.14177701
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11068012
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08321299
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06015798
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03365919
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01876227
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.01548375
88* UTX_26944678_Chip-Seq_JUKART_Human1.01390387
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00045938
90* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99502290
91MAF_26560356_Chip-Seq_TH1_Human0.99431812
92* NCOR1_26117541_ChIP-Seq_K562_Human0.99014353
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98623049
94* TCF7_22412390_ChIP-Seq_EML_Mouse0.98231958
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97905393
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97765633
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97489232
98MYB_26560356_Chip-Seq_TH1_Human0.97461901
99SPI1_23547873_ChIP-Seq_NB4_Human0.96928380
100MYB_26560356_Chip-Seq_TH2_Human0.96769694
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.96226025
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95917432
103* TP53_22127205_ChIP-Seq_IMR90_Human0.95909061
104P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95077656
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94345910
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93142731
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92990797
108RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92419148
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92207309
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90903029
111* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90509289
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90184239
113YY1_21170310_ChIP-Seq_MESCs_Mouse0.89904497
114CLOCK_20551151_ChIP-Seq_293T_Human0.89728406
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89676610
116* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89556874
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.88871850
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88670482
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88211909
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87772346
121UBF1/2_26484160_Chip-Seq_HMECs_Human0.86389469
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85771785
123RACK7_27058665_Chip-Seq_MCF-7_Human0.85358593
124RUNX1_22412390_ChIP-Seq_EML_Mouse0.84795332
125CHD1_26751641_Chip-Seq_LNCaP_Human0.84730967
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83998224
127LXR_22292898_ChIP-Seq_THP-1_Human0.83782157
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83702298
129TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83586716
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82148356
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79308748
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78413490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.35112621
2MP0003693_abnormal_embryo_hatching4.09997038
3MP0003111_abnormal_nucleus_morphology3.93343420
4MP0004957_abnormal_blastocyst_morpholog3.84819380
5MP0008057_abnormal_DNA_replication3.74382425
6MP0003077_abnormal_cell_cycle3.55229931
7MP0010352_gastrointestinal_tract_polyps3.44726206
8MP0008438_abnormal_cutaneous_collagen3.28422521
9MP0002396_abnormal_hematopoietic_system3.00890313
10MP0001661_extended_life_span2.93992833
11MP0010307_abnormal_tumor_latency2.56891389
12MP0008007_abnormal_cellular_replicative2.46527496
13MP0001730_embryonic_growth_arrest2.43155922
14MP0000350_abnormal_cell_proliferation2.33453140
15MP0008058_abnormal_DNA_repair2.32509723
16MP0000013_abnormal_adipose_tissue2.31440517
17MP0004185_abnormal_adipocyte_glucose2.19513942
18MP0008932_abnormal_embryonic_tissue2.19432012
19MP0003123_paternal_imprinting2.05513077
20MP0004272_abnormal_basement_membrane2.05082733
21MP0005670_abnormal_white_adipose2.03828532
22MP0005076_abnormal_cell_differentiation1.99965992
23MP0004808_abnormal_hematopoietic_stem1.97870037
24MP0002877_abnormal_melanocyte_morpholog1.91395338
25MP0005360_urolithiasis1.90481996
26MP0000490_abnormal_crypts_of1.86279357
27MP0003705_abnormal_hypodermis_morpholog1.85085211
28MP0005623_abnormal_meninges_morphology1.82858661
29MP0001672_abnormal_embryogenesis/_devel1.78687569
30MP0005380_embryogenesis_phenotype1.78687569
31MP0001697_abnormal_embryo_size1.77183060
32MP0004197_abnormal_fetal_growth/weight/1.70867525
33MP0008995_early_reproductive_senescence1.69541590
34MP0003984_embryonic_growth_retardation1.67590193
35MP0002080_prenatal_lethality1.67246544
36MP0002084_abnormal_developmental_patter1.64661181
37MP0002088_abnormal_embryonic_growth/wei1.64135136
38MP0003941_abnormal_skin_development1.62848720
39MP0002938_white_spotting1.62257877
40MP0002086_abnormal_extraembryonic_tissu1.61610721
41MP0005257_abnormal_intraocular_pressure1.60345388
42MP0003763_abnormal_thymus_physiology1.57962573
43MP0002085_abnormal_embryonic_tissue1.56425348
44MP0009697_abnormal_copulation1.55047189
45MP0000003_abnormal_adipose_tissue1.54553359
46MP0003942_abnormal_urinary_system1.52944840
47MP0002019_abnormal_tumor_incidence1.52520863
48MP0000703_abnormal_thymus_morphology1.51275394
49MP0000534_abnormal_ureter_morphology1.48169721
50MP0002398_abnormal_bone_marrow1.45371408
51MP0006054_spinal_hemorrhage1.43263875
52MP0000313_abnormal_cell_death1.42563657
53MP0003566_abnormal_cell_adhesion1.40440030
54MP0003890_abnormal_embryonic-extraembry1.37806758
55MP0000566_synostosis1.37163225
56MP0009333_abnormal_splenocyte_physiolog1.35233412
57MP0002060_abnormal_skin_morphology1.33995197
58MP0003121_genomic_imprinting1.33031923
59MP0002722_abnormal_immune_system1.32919598
60MP0000762_abnormal_tongue_morphology1.32548923
61MP0009053_abnormal_anal_canal1.30653426
62MP0005397_hematopoietic_system_phenotyp1.29769508
63MP0001545_abnormal_hematopoietic_system1.29769508
64MP0003786_premature_aging1.29477768
65MP0003937_abnormal_limbs/digits/tail_de1.28296436
66MP0009250_abnormal_appendicular_skeleto1.26577788
67MP0003315_abnormal_perineum_morphology1.26135165
68MP0005503_abnormal_tendon_morphology1.25012287
69MP0000689_abnormal_spleen_morphology1.24647970
70MP0005023_abnormal_wound_healing1.23871175
71MP0003567_abnormal_fetal_cardiomyocyte1.22561043
72MP0000678_abnormal_parathyroid_gland1.21621259
73MP0003300_gastrointestinal_ulcer1.16624438
74MP0009278_abnormal_bone_marrow1.15402916
75MP0001293_anophthalmia1.10275271
76MP0008877_abnormal_DNA_methylation1.10118382
77MP0003186_abnormal_redox_activity1.07095416
78MP0000371_diluted_coat_color1.05593324
79MP0005646_abnormal_pituitary_gland1.05227760
80MP0002429_abnormal_blood_cell1.04652810
81MP0000537_abnormal_urethra_morphology1.04171082
82MP0001915_intracranial_hemorrhage1.03344787
83MP0000858_altered_metastatic_potential1.02400460
84MP0000432_abnormal_head_morphology1.02306346
85MP0003385_abnormal_body_wall1.01258278
86MP0005275_abnormal_skin_tensile1.00296923
87MP0002234_abnormal_pharynx_morphology0.97463330
88MP0000372_irregular_coat_pigmentation0.96717664
89MP0001800_abnormal_humoral_immune0.96477809
90MP0003935_abnormal_craniofacial_develop0.94918951
91MP0005367_renal/urinary_system_phenotyp0.94684441
92MP0000516_abnormal_urinary_system0.94684441
93MP0005621_abnormal_cell_physiology0.94404232
94MP0000716_abnormal_immune_system0.94218223
95MP0003115_abnormal_respiratory_system0.94117909
96MP0009384_cardiac_valve_regurgitation0.92247993
97MP0003279_aneurysm0.92172882
98MP0010030_abnormal_orbit_morphology0.91671043
99MP0005384_cellular_phenotype0.91028617
100MP0003806_abnormal_nucleotide_metabolis0.90740526
101MP0000685_abnormal_immune_system0.90017907
102MP0002075_abnormal_coat/hair_pigmentati0.88239715
103MP0000358_abnormal_cell_content/0.87959451
104MP0000733_abnormal_muscle_development0.87840121
105MP0003755_abnormal_palate_morphology0.87475935
106MP0001340_abnormal_eyelid_morphology0.85467034
107MP0008770_decreased_survivor_rate0.85221629
108MP0002405_respiratory_system_inflammati0.84154236
109MP0005197_abnormal_uvea_morphology0.83842760
110MP0009672_abnormal_birth_weight0.83006862
111MP0000049_abnormal_middle_ear0.82717810
112MP0004858_abnormal_nervous_system0.81954754
113MP0001243_abnormal_dermal_layer0.81376692
114MP0002095_abnormal_skin_pigmentation0.81217590
115MP0003303_peritoneal_inflammation0.81047489
116MP0009703_decreased_birth_body0.80167296
117MP0002420_abnormal_adaptive_immunity0.78664448
118MP0002111_abnormal_tail_morphology0.78510299
119MP0002269_muscular_atrophy0.77043123
120MP0005174_abnormal_tail_pigmentation0.77030972
121MP0000428_abnormal_craniofacial_morphol0.76764090
122MP0000477_abnormal_intestine_morphology0.76396077
123MP0002452_abnormal_antigen_presenting0.76188731
124MP0001819_abnormal_immune_cell0.76094364
125MP0000467_abnormal_esophagus_morphology0.75942588
126MP0002160_abnormal_reproductive_system0.75488642
127MP0000750_abnormal_muscle_regeneration0.75022903
128MP0000627_abnormal_mammary_gland0.75012130
129MP0005508_abnormal_skeleton_morphology0.74741995
130MP0002925_abnormal_cardiovascular_devel0.74382055
131MP0004264_abnormal_extraembryonic_tissu0.73956477
132MP0010368_abnormal_lymphatic_system0.72998026
133MP0002697_abnormal_eye_size0.71778822
134MP0002092_abnormal_eye_morphology0.71754861
135MP0000579_abnormal_nail_morphology0.71715750
136MP0002166_altered_tumor_susceptibility0.70835996
137MP0010234_abnormal_vibrissa_follicle0.70580785
138MP0001270_distended_abdomen0.70181090
139MP0004233_abnormal_muscle_weight0.70091265
140MP0001849_ear_inflammation0.69863044
141MP0003950_abnormal_plasma_membrane0.69171452
142MP0001286_abnormal_eye_development0.68889348
143MP0003448_altered_tumor_morphology0.67838391
144MP0003283_abnormal_digestive_organ0.66019377
145MP0003119_abnormal_digestive_system0.65997680
146MP0005075_abnormal_melanosome_morpholog0.64149800
147MP0010155_abnormal_intestine_physiology0.63269491
148MP0002723_abnormal_immune_serum0.63221672
149MP0004133_heterotaxia0.62668276
150MP0002006_tumorigenesis0.62126254
151MP0001186_pigmentation_phenotype0.61600385
152MP0003221_abnormal_cardiomyocyte_apopto0.59759253
153MP0003091_abnormal_cell_migration0.59197883
154MP0001348_abnormal_lacrimal_gland0.58848023
155MP0005671_abnormal_response_to0.55957439
156MP0003866_abnormal_defecation0.55080476

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.34907904
2Abnormality of alanine metabolism (HP:0010916)5.34907904
3Hyperalaninemia (HP:0003348)5.34907904
4Abnormal umbilical cord blood vessels (HP:0011403)4.62140502
5Single umbilical artery (HP:0001195)4.62140502
6Abnormality of the fetal cardiovascular system (HP:0010948)4.62140502
7Esophageal varix (HP:0002040)4.04264532
8Abnormality of the umbilical cord (HP:0010881)3.78621489
9Premature rupture of membranes (HP:0001788)3.73825027
10Ependymoma (HP:0002888)3.64293458
11Biconcave vertebral bodies (HP:0004586)3.62454151
12Reticulocytopenia (HP:0001896)3.55820172
13Selective tooth agenesis (HP:0001592)3.40842327
14Protrusio acetabuli (HP:0003179)3.31211662
15Homocystinuria (HP:0002156)3.24946825
16Abnormality of homocysteine metabolism (HP:0010919)3.24946825
17Birth length less than 3rd percentile (HP:0003561)3.21168200
18White forelock (HP:0002211)3.18014038
19Abnormality of cells of the erythroid lineage (HP:0012130)3.04275239
20Chromsome breakage (HP:0040012)3.04047514
21Medulloblastoma (HP:0002885)3.02822680
22Basal cell carcinoma (HP:0002671)2.99297361
23Constricted visual fields (HP:0001133)2.98654665
24Myocardial infarction (HP:0001658)2.88788936
25Colon cancer (HP:0003003)2.83258501
26Abnormality of the phalanges of the hallux (HP:0010057)2.83088818
27Abnormal number of erythroid precursors (HP:0012131)2.82335123
28Disproportionate tall stature (HP:0001519)2.80255492
29Deviation of the thumb (HP:0009603)2.79801542
30Proximal placement of thumb (HP:0009623)2.72799429
31Patchy hypopigmentation of hair (HP:0011365)2.72692201
32Spontaneous hematomas (HP:0007420)2.72620688
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72021017
34Rhabdomyosarcoma (HP:0002859)2.71302379
35Reduced subcutaneous adipose tissue (HP:0003758)2.69193634
36Cutaneous melanoma (HP:0012056)2.68878586
37Volvulus (HP:0002580)2.67271180
38Abnormality of chromosome stability (HP:0003220)2.64865095
39Astrocytoma (HP:0009592)2.61495688
40Abnormality of the astrocytes (HP:0100707)2.61495688
41Abnormal number of incisors (HP:0011064)2.59598569
42Increased density of long bones (HP:0006392)2.59530339
43IgM deficiency (HP:0002850)2.53195251
44Abnormality of the anterior horn cell (HP:0006802)2.52104150
45Degeneration of anterior horn cells (HP:0002398)2.52104150
46Abnormalities of placenta or umbilical cord (HP:0001194)2.49122171
47Increased nuchal translucency (HP:0010880)2.49079954
48Agnosia (HP:0010524)2.46691987
49Insomnia (HP:0100785)2.46261842
50Myelodysplasia (HP:0002863)2.46192018
51Arteriovenous malformation (HP:0100026)2.43507238
52Missing ribs (HP:0000921)2.41450649
53Fatigue (HP:0012378)2.38760280
54Thrombocytosis (HP:0001894)2.38585564
5511 pairs of ribs (HP:0000878)2.38510734
56Conjunctival telangiectasia (HP:0000524)2.38023328
57Prominent nose (HP:0000448)2.34220139
58High pitched voice (HP:0001620)2.33340034
59Mitral valve prolapse (HP:0001634)2.32124121
60Duplication of thumb phalanx (HP:0009942)2.31279865
61Abnormality of subcutaneous fat tissue (HP:0001001)2.29641927
62Squamous cell carcinoma (HP:0002860)2.28011401
63Pallor (HP:0000980)2.27471308
64Aplastic anemia (HP:0001915)2.26652622
65Progressive muscle weakness (HP:0003323)2.23801536
66Cafe-au-lait spot (HP:0000957)2.22263234
67Abnormality of sulfur amino acid metabolism (HP:0004339)2.22033550
68Neoplasm of striated muscle (HP:0009728)2.21970058
69Premature graying of hair (HP:0002216)2.21028988
70Thin ribs (HP:0000883)2.20488321
71Neoplasm of the oral cavity (HP:0100649)2.19669830
72Amaurosis fugax (HP:0100576)2.18396295
73Decreased subcutaneous fat (HP:0001002)2.16657318
74Patellar aplasia (HP:0006443)2.16297588
75Long palpebral fissure (HP:0000637)2.15709929
76Congenital sensorineural hearing impairment (HP:0008527)2.14843691
77Glioma (HP:0009733)2.14350202
78Abnormality of the calcaneus (HP:0008364)2.13370218
79Freckling (HP:0001480)2.12966192
80Lymphoma (HP:0002665)2.12086385
81Overlapping toe (HP:0001845)2.11160136
82Spinal cord lesions (HP:0100561)2.11137057
83Syringomyelia (HP:0003396)2.11137057
84Breech presentation (HP:0001623)2.05581107
85Absent thumb (HP:0009777)2.05477143
86Abnormality of carpal bone ossification (HP:0006257)2.03637551
87Abnormality of serum amino acid levels (HP:0003112)2.03395464
88Abnormality of cochlea (HP:0000375)2.02765171
89Abnormality of the preputium (HP:0100587)2.02417995
90Abnormality of reticulocytes (HP:0004312)2.02057780
91Abnormality of the tricuspid valve (HP:0001702)2.01339325
92Hemangiomatosis (HP:0007461)2.01213397
93Meckel diverticulum (HP:0002245)2.00605230
94Ileus (HP:0002595)2.00530141
95Breast hypoplasia (HP:0003187)1.99297592
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.98799811
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98691414
98Neoplasm of the pancreas (HP:0002894)1.98564375
99Hypoalphalipoproteinemia (HP:0003233)1.97691582
100Hyperacusis (HP:0010780)1.97684026
101Abnormality of the ileum (HP:0001549)1.97647300
102Hypoplastic left heart (HP:0004383)1.96869576
103Progressive external ophthalmoplegia (HP:0000590)1.96869080
104Aplasia/Hypoplasia of the patella (HP:0006498)1.93921531
105Abnormality of the labia minora (HP:0012880)1.90819110
106Ankle contracture (HP:0006466)1.89211410
107Macrocytic anemia (HP:0001972)1.88292027
108Heterochromia iridis (HP:0001100)1.87213639
109Angiofibromas (HP:0010615)1.86322851
110Adenoma sebaceum (HP:0009720)1.86322851
111Atresia of the external auditory canal (HP:0000413)1.86244328
112Short 4th metacarpal (HP:0010044)1.85081200
113Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85081200
114Genu recurvatum (HP:0002816)1.84461964
115Premature ovarian failure (HP:0008209)1.84024125
116Poikiloderma (HP:0001029)1.83903727
117Bladder diverticulum (HP:0000015)1.83274370
118Visceral angiomatosis (HP:0100761)1.83127716
119Abnormality of T cells (HP:0002843)1.83083770
120Oral leukoplakia (HP:0002745)1.83009624
121Abnormality of DNA repair (HP:0003254)1.82785384
122Trismus (HP:0000211)1.82600570
123Complete atrioventricular canal defect (HP:0001674)1.82440490
124Glossoptosis (HP:0000162)1.82100033
125Malignant gastrointestinal tract tumors (HP:0006749)1.81764655
126Gastrointestinal carcinoma (HP:0002672)1.81764655
127Biliary tract neoplasm (HP:0100574)1.81658967
128Duplicated collecting system (HP:0000081)1.81250488
129T lymphocytopenia (HP:0005403)1.80441366
130Rib fusion (HP:0000902)1.79964463
131Sloping forehead (HP:0000340)1.79710869
132Absent radius (HP:0003974)1.79686393
133Skin tags (HP:0010609)1.79048172
134Small intestinal stenosis (HP:0012848)1.78942560
135Duodenal stenosis (HP:0100867)1.78942560
136Bone marrow hypocellularity (HP:0005528)1.78519067
137Subacute progressive viral hepatitis (HP:0006572)1.78227219
138Slender long bone (HP:0003100)1.77761810
139Abnormal ossification of hand bones (HP:0005921)1.77392447
140Abnormality of glycolysis (HP:0004366)1.77374709
141Impulsivity (HP:0100710)1.76226100
142Hypopigmentation of the fundus (HP:0007894)1.76066020
143Carpal bone hypoplasia (HP:0001498)1.75197545
144Rough bone trabeculation (HP:0100670)1.74761098
145Soft skin (HP:0000977)1.74399361
146Broad palm (HP:0001169)1.74242956
147Abnormality of T cell physiology (HP:0011840)1.74189944
148Back pain (HP:0003418)1.73982181
149Ectopic kidney (HP:0000086)1.73837101
150Abnormality of dentin (HP:0010299)1.73700589
151Persistence of primary teeth (HP:0006335)1.73494113
152Facial hemangioma (HP:0000329)1.73308016
153Blue sclerae (HP:0000592)1.72681393
154Asplenia (HP:0001746)1.72189631
155Bowel diverticulosis (HP:0005222)1.72071087
156Ectopia lentis (HP:0001083)1.71726541
157Abnormality of the carotid arteries (HP:0005344)1.71207847
158Spinal muscular atrophy (HP:0007269)1.71130011
159Preauricular skin tag (HP:0000384)1.70774523
160Abnormality of the vasculature of the conjunctiva (HP:0008054)1.70253841
161Conjugated hyperbilirubinemia (HP:0002908)1.70244310
162Aplasia/hypoplasia of the humerus (HP:0006507)1.68757569
163Abnormality of the fingertips (HP:0001211)1.67164172
164Ulnar bowing (HP:0003031)1.67045462
165Long eyelashes (HP:0000527)1.66874985
166Fragile skin (HP:0001030)1.66814461
167IgA deficiency (HP:0002720)1.66397068
168Acute myeloid leukemia (HP:0004808)1.65970297
169Myopathic facies (HP:0002058)1.64387849
170Atrophic scars (HP:0001075)1.62896930
171Flat acetabular roof (HP:0003180)1.61808649
172Abnormal connection of the cardiac segments (HP:0011545)1.61405110
173Abnormal ventriculo-arterial connection (HP:0011563)1.61405110
174Transposition of the great arteries (HP:0001669)1.61405110
175Abnormal tarsal ossification (HP:0008369)1.60850013
176Calcaneovalgus deformity (HP:0001848)1.60266794
177Poor speech (HP:0002465)1.59940181
178Increased serum pyruvate (HP:0003542)1.58787435
179Shallow orbits (HP:0000586)1.57520899
180Renal duplication (HP:0000075)1.57065743
181Abnormality of the acetabulum (HP:0003170)1.56430516
182Hypoplastic heart (HP:0001961)1.55316405
183Abnormality of the renal collecting system (HP:0004742)1.54927267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.31915783
2EEF2K3.62063773
3WEE13.14827348
4SMG12.98795155
5MAP3K32.95667187
6CDK122.92985925
7PKN22.90386924
8NEK22.61899843
9PASK2.49808758
10CDK92.45595190
11BUB12.41339947
12SCYL22.25638920
13MAP3K102.22344640
14STK102.17278605
15TSSK62.08872988
16TTK2.08667296
17FLT32.07856607
18RPS6KB22.05995193
19CCNB11.91375347
20EIF2AK11.79986237
21MAP4K11.79658497
22NEK11.73582780
23CDK71.62680745
24PBK1.62257112
25ATR1.61441522
26TESK21.60528938
27LATS21.60458946
28MAP3K81.59778394
29CDK41.53252471
30ALK1.49242433
31LRRK21.42954329
32VRK21.42911692
33SRPK11.42619257
34TLK11.42521515
35PLK11.41258757
36IRAK31.39671396
37TRIB31.39292398
38AURKB1.36208674
39NME21.35984359
40BRSK21.33473921
41CHEK11.31855224
42TGFBR11.30551399
43ACVR1B1.30118284
44RPS6KA41.29819625
45STK31.23539197
46MKNK11.22401334
47EPHB21.22153356
48BRD41.17190754
49TAF11.15476576
50EIF2AK31.14503786
51EPHA21.13342915
52MST1R1.13282329
53FGR1.11861121
54LATS11.10985199
55PLK31.10104731
56GRK61.07191911
57CHEK21.05355711
58PIM11.03921245
59PAK41.03412708
60STK41.02426811
61CDK60.96932481
62ATM0.95904425
63STK240.95630150
64VRK10.95477327
65JAK30.94808424
66PTK20.94630035
67AURKA0.86911308
68MTOR0.86814716
69* CDK20.86499736
70TTN0.84941454
71ERBB40.83406648
72ZAP700.81444418
73NTRK10.79427572
74BTK0.77679226
75CDK80.76711154
76BRSK10.76176630
77BMX0.75741574
78DYRK30.73810506
79PAK20.71068304
80LMTK20.70004620
81PDK20.67070696
82PTK60.66878925
83MAP2K30.66713926
84CSF1R0.66203351
85PRPF4B0.65319878
86PIM20.64446130
87MAP2K10.63606787
88ZAK0.63395390
89SIK10.61885456
90CSNK2A20.60973312
91CDK10.58561653
92SGK2230.57995997
93SGK4940.57995997
94NTRK20.55688687
95PAK10.55574679
96TESK10.55409361
97PLK40.54715083
98FGFR10.54670731
99MKNK20.54532912
100CLK10.54484850
101BRAF0.54204521
102MAPKAPK30.52652528
103PDGFRA0.52297396
104MARK30.51191466
105MELK0.50762200
106ITK0.50753661
107SGK30.49359210
108RPS6KA50.46316630
109MAPKAPK50.45427607
110EIF2AK20.45212559
111MAP3K90.44597541
112TEC0.44245026
113ARAF0.43349976
114CAMK1G0.43289381
115MET0.42901744
116PRKDC0.42869097
117LCK0.42467733
118RPS6KA10.42339876
119MAP3K110.40774535
120AKT20.39775530
121CAMK1D0.39559231
122CSNK1D0.39074316
123NME10.37167561
124CSNK2A10.36893297
125CSNK1E0.36790537
126MAPK140.36320884
127KDR0.36186697
128HIPK20.34541889
129RPS6KB10.33905102
130KIT0.33666628
131ICK0.32591736
132MAPKAPK20.31819092
133ILK0.31622114
134CHUK0.30435857
135MAPK10.28828962
136RPS6KC10.28631360
137RPS6KL10.28631360

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.81724380
2Mismatch repair_Homo sapiens_hsa034304.02111049
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14638803
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.97825569
5Spliceosome_Homo sapiens_hsa030402.96283868
6RNA transport_Homo sapiens_hsa030132.94471109
7* One carbon pool by folate_Homo sapiens_hsa006702.79890352
8Base excision repair_Homo sapiens_hsa034102.73669137
9Cell cycle_Homo sapiens_hsa041102.71669757
10Ribosome_Homo sapiens_hsa030102.68118253
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.64034000
12Nucleotide excision repair_Homo sapiens_hsa034202.52845674
13Homologous recombination_Homo sapiens_hsa034402.52033986
14Arginine biosynthesis_Homo sapiens_hsa002202.50743121
15Non-homologous end-joining_Homo sapiens_hsa034502.22525578
16Sulfur relay system_Homo sapiens_hsa041222.19397602
17Fanconi anemia pathway_Homo sapiens_hsa034601.88544734
18RNA polymerase_Homo sapiens_hsa030201.85866004
19mRNA surveillance pathway_Homo sapiens_hsa030151.83647727
20RNA degradation_Homo sapiens_hsa030181.67679084
21Pyrimidine metabolism_Homo sapiens_hsa002401.67356258
22p53 signaling pathway_Homo sapiens_hsa041151.54747738
23Viral carcinogenesis_Homo sapiens_hsa052031.51194710
24Systemic lupus erythematosus_Homo sapiens_hsa053221.50514948
25Proteasome_Homo sapiens_hsa030501.50108304
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49976641
27Vitamin B6 metabolism_Homo sapiens_hsa007501.49297808
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42361937
29Sulfur metabolism_Homo sapiens_hsa009201.38577451
30Antigen processing and presentation_Homo sapiens_hsa046121.31864768
31Carbon metabolism_Homo sapiens_hsa012001.25108760
32Primary immunodeficiency_Homo sapiens_hsa053401.21674926
33Epstein-Barr virus infection_Homo sapiens_hsa051691.19737748
34MicroRNAs in cancer_Homo sapiens_hsa052061.09261273
35Chronic myeloid leukemia_Homo sapiens_hsa052201.08838737
36HTLV-I infection_Homo sapiens_hsa051661.07264999
37Basal transcription factors_Homo sapiens_hsa030221.06493576
38Herpes simplex infection_Homo sapiens_hsa051681.06372015
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06241183
40Small cell lung cancer_Homo sapiens_hsa052221.03653827
41ECM-receptor interaction_Homo sapiens_hsa045120.98079293
42Thyroid cancer_Homo sapiens_hsa052160.96388003
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.96356445
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.96135260
45Folate biosynthesis_Homo sapiens_hsa007900.95841719
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93676822
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93282500
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91837372
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87934687
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87405504
51Biosynthesis of amino acids_Homo sapiens_hsa012300.86313192
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86286498
53Vibrio cholerae infection_Homo sapiens_hsa051100.83837959
54Colorectal cancer_Homo sapiens_hsa052100.83822703
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83254662
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82862354
57Oocyte meiosis_Homo sapiens_hsa041140.81863907
58Acute myeloid leukemia_Homo sapiens_hsa052210.79861687
59Measles_Homo sapiens_hsa051620.79585523
60Hepatitis B_Homo sapiens_hsa051610.78950029
61Legionellosis_Homo sapiens_hsa051340.77516586
62Apoptosis_Homo sapiens_hsa042100.77044895
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76613548
64Selenocompound metabolism_Homo sapiens_hsa004500.75987775
65mTOR signaling pathway_Homo sapiens_hsa041500.71612118
66Alcoholism_Homo sapiens_hsa050340.71412443
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.71258681
68Bladder cancer_Homo sapiens_hsa052190.69316978
69Purine metabolism_Homo sapiens_hsa002300.68740855
70Pentose phosphate pathway_Homo sapiens_hsa000300.68655717
71Arginine and proline metabolism_Homo sapiens_hsa003300.67743715
72B cell receptor signaling pathway_Homo sapiens_hsa046620.65893694
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65110604
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64394209
75Shigellosis_Homo sapiens_hsa051310.64377509
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63107253
77HIF-1 signaling pathway_Homo sapiens_hsa040660.62943599
78Other glycan degradation_Homo sapiens_hsa005110.61445077
79N-Glycan biosynthesis_Homo sapiens_hsa005100.60973943
80Viral myocarditis_Homo sapiens_hsa054160.60803897
81Pyruvate metabolism_Homo sapiens_hsa006200.60716392
82Non-small cell lung cancer_Homo sapiens_hsa052230.60662340
83T cell receptor signaling pathway_Homo sapiens_hsa046600.60083229
84Pancreatic cancer_Homo sapiens_hsa052120.56905964
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55850796
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54680160
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54230718
88Hematopoietic cell lineage_Homo sapiens_hsa046400.52479482
89Adherens junction_Homo sapiens_hsa045200.51888543
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51001518
91Notch signaling pathway_Homo sapiens_hsa043300.50629207
92Proteoglycans in cancer_Homo sapiens_hsa052050.50166547
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.50082854
94Prion diseases_Homo sapiens_hsa050200.48793016
95Prostate cancer_Homo sapiens_hsa052150.48466477
96TGF-beta signaling pathway_Homo sapiens_hsa043500.48159288
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47860200
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46385703
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.46267317
100Hippo signaling pathway_Homo sapiens_hsa043900.46121283
101Hedgehog signaling pathway_Homo sapiens_hsa043400.45911523
102Pathways in cancer_Homo sapiens_hsa052000.45759983
103Vitamin digestion and absorption_Homo sapiens_hsa049770.43693297
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43340026
105Fatty acid biosynthesis_Homo sapiens_hsa000610.43000515
106AMPK signaling pathway_Homo sapiens_hsa041520.42455680
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42160708
108Toxoplasmosis_Homo sapiens_hsa051450.41536730
109Leishmaniasis_Homo sapiens_hsa051400.41249275
110Glioma_Homo sapiens_hsa052140.38355202
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.38178719
112Endometrial cancer_Homo sapiens_hsa052130.37279014
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.36864874
114Wnt signaling pathway_Homo sapiens_hsa043100.36855593
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.36520517
116Lysine degradation_Homo sapiens_hsa003100.36085122
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35897216
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34795075
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33674920
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33113347
121Influenza A_Homo sapiens_hsa051640.31571472
122Melanoma_Homo sapiens_hsa052180.31355783
123Focal adhesion_Homo sapiens_hsa045100.31014499
124Fructose and mannose metabolism_Homo sapiens_hsa000510.29213535
125Galactose metabolism_Homo sapiens_hsa000520.29160285
126VEGF signaling pathway_Homo sapiens_hsa043700.29072828
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28149466
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27473246
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.27244133
130Glutathione metabolism_Homo sapiens_hsa004800.27138281
131Basal cell carcinoma_Homo sapiens_hsa052170.26976259
132Platelet activation_Homo sapiens_hsa046110.25452826
133Collecting duct acid secretion_Homo sapiens_hsa049660.22743025

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