ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sulfation (GO:0051923)	6.22651979
2	behavioral response to nicotine (GO:0035095)	5.81013047
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.94254323
4	cellular response to ATP (GO:0071318)	4.55828403
5	cell proliferation in forebrain (GO:0021846)	4.51325056
6	DNA deamination (GO:0045006)	4.41112960
7	regulation of glomerulus development (GO:0090192)	4.40358109
8	kynurenine metabolic process (GO:0070189)	4.11850264
9	tryptophan catabolic process (GO:0006569)	4.11173073
10	indole-containing compound catabolic process (GO:0042436)	4.11173073
11	indolalkylamine catabolic process (GO:0046218)	4.11173073
12	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.83479002
13	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.83479002
14	gamma-aminobutyric acid transport (GO:0015812)	3.78236411
15	negative regulation of systemic arterial blood pressure (GO:0003085)	3.77582753
16	indolalkylamine metabolic process (GO:0006586)	3.77302681
17	regulation of cell proliferation involved in kidney development (GO:1901722)	3.75447467
18	positive regulation of cAMP-mediated signaling (GO:0043950)	3.74251549
19	tryptophan metabolic process (GO:0006568)	3.70890448
20	protein polyglutamylation (GO:0018095)	3.70093608
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.61793244
22	NADH dehydrogenase complex assembly (GO:0010257)	3.61793244
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.61793244
24	otic vesicle formation (GO:0030916)	3.50118321
25	negative regulation of mast cell activation (GO:0033004)	3.48714207
26	negative regulation of telomere maintenance (GO:0032205)	3.44467800
27	regulation of DNA endoreduplication (GO:0032875)	3.43220081
28	positive regulation of fatty acid oxidation (GO:0046321)	3.42372237
29	L-fucose catabolic process (GO:0042355)	3.42044351
30	fucose catabolic process (GO:0019317)	3.42044351
31	L-fucose metabolic process (GO:0042354)	3.42044351
32	protein complex biogenesis (GO:0070271)	3.41390151
33	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.37319801
34	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.27747151
35	pharyngeal system development (GO:0060037)	3.20039065
36	flavonoid metabolic process (GO:0009812)	3.19741052
37	negative regulation of response to food (GO:0032096)	3.17946771
38	negative regulation of appetite (GO:0032099)	3.17946771
39	indole-containing compound metabolic process (GO:0042430)	3.15901988
40	regulation of posttranscriptional gene silencing (GO:0060147)	3.13285410
41	regulation of gene silencing by miRNA (GO:0060964)	3.13285410
42	regulation of gene silencing by RNA (GO:0060966)	3.13285410
43	regulation of phospholipid biosynthetic process (GO:0071071)	3.12472181
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10855351
45	somite development (GO:0061053)	3.07353384
46	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.07352815
47	GPI anchor metabolic process (GO:0006505)	3.06799944
48	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.99892414
49	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.98528588
50	kidney morphogenesis (GO:0060993)	2.96950804
51	serotonin metabolic process (GO:0042428)	2.95180335
52	cytidine deamination (GO:0009972)	2.95010441
53	cytidine metabolic process (GO:0046087)	2.95010441
54	cytidine catabolic process (GO:0006216)	2.95010441
55	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.94751209
56	regulation of collateral sprouting (GO:0048670)	2.94413778
57	limb bud formation (GO:0060174)	2.92965973
58	transmission of nerve impulse (GO:0019226)	2.92505964
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.92174676
60	response to pheromone (GO:0019236)	2.84731431
61	reflex (GO:0060004)	2.83642970
62	primary amino compound metabolic process (GO:1901160)	2.79275239
63	detection of light stimulus involved in visual perception (GO:0050908)	2.78727004
64	detection of light stimulus involved in sensory perception (GO:0050962)	2.78727004
65	regulation of mesoderm development (GO:2000380)	2.77886371
66	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.77879587
67	photoreceptor cell development (GO:0042461)	2.75505365
68	parturition (GO:0007567)	2.74963687
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.74227336
70	dorsal/ventral axis specification (GO:0009950)	2.73815416
71	regulation of action potential (GO:0098900)	2.70969575
72	response to UV-C (GO:0010225)	2.69456037
73	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.69291065
74	neuronal action potential (GO:0019228)	2.68795406
75	regulation of hippo signaling (GO:0035330)	2.68625828
76	amine catabolic process (GO:0009310)	2.67310237
77	cellular biogenic amine catabolic process (GO:0042402)	2.67310237
78	negative regulation by host of viral transcription (GO:0043922)	2.65413049
79	regulation of sequestering of triglyceride (GO:0010889)	2.62302644
80	N-acetylglucosamine metabolic process (GO:0006044)	2.62247290
81	eye photoreceptor cell development (GO:0042462)	2.59175274
82	dentate gyrus development (GO:0021542)	2.58458033
83	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.55923447
84	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.55813709
85	positive regulation of metanephros development (GO:0072216)	2.53387310
86	axoneme assembly (GO:0035082)	2.53008889
87	spinal cord motor neuron differentiation (GO:0021522)	2.52062011
88	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.51228763
89	cellular anion homeostasis (GO:0030002)	2.50483152
90	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.49452045
91	ATP synthesis coupled proton transport (GO:0015986)	2.49452045
92	positive regulation of fatty acid transport (GO:2000193)	2.46482727
93	adaptation of signaling pathway (GO:0023058)	2.42854164
94	positive regulation of glomerulus development (GO:0090193)	2.41758845
95	negative regulation of multicellular organism growth (GO:0040015)	2.41186500
96	positive regulation of digestive system process (GO:0060456)	2.40953692
97	prostate gland growth (GO:0060736)	2.40724914
98	embryonic hindlimb morphogenesis (GO:0035116)	2.40355930
99	platelet dense granule organization (GO:0060155)	2.40237141
100	nephron tubule morphogenesis (GO:0072078)	2.39823088

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.10426302
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.87689171
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.98958260
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.81353332
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.80805708
6	VDR_22108803_ChIP-Seq_LS180_Human	2.58695778
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46003442
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.23753632
9	EWS_26573619_Chip-Seq_HEK293_Human	2.20382818
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.17852066
11	FUS_26573619_Chip-Seq_HEK293_Human	2.15479226
12	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.08468398
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06129775
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.98303055
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.97890370
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.97216455
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.96094906
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93115918
19	P300_19829295_ChIP-Seq_ESCs_Human	1.81503628
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81346712
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.81169192
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.78949397
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77517962
24	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76702486
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.75671667
26	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.75081525
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73529226
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64618613
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63449084
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62392451
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.59976211
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59829765
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.55444307
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.54097163
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48329246
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.48329246
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.47099902
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.46980291
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.45541606
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.44921899
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40289322
42	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33753487
43	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33250619
44	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.33139379
45	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.31990958
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31918225
47	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30336717
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27432139
49	STAT3_23295773_ChIP-Seq_U87_Human	1.26602053
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.25607388
51	TCF4_23295773_ChIP-Seq_U87_Human	1.25047097
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25024934
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.23821613
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23560753
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23377691
56	AR_25329375_ChIP-Seq_VCAP_Human	1.22309051
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21675602
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.21643797
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21441467
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21441467
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21298229
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20690006
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.20413987
64	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.20371098
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20211378
66	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18664652
67	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.18375860
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18084910
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18084910
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17278721
71	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.16093462
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14380774
73	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14260785
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.14098886
75	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.14039892
76	NCOR_22424771_ChIP-Seq_293T_Human	1.13931883
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12148636
78	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.11977794
79	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11410095
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10359486
81	ELK1_19687146_ChIP-ChIP_HELA_Human	1.09339095
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07823277
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07642493
84	TCF4_22108803_ChIP-Seq_LS180_Human	1.06783401
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05111925
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02207345
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01079001
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00740202
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99550576
90	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.98413169
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97924537
92	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.97454342
93	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97150798
94	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96866593
95	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96866593
96	TP53_16413492_ChIP-PET_HCT116_Human	0.96462463
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96355586
98	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.96159871
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.95510693
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95369630

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.01330892
2	MP0005646_abnormal_pituitary_gland	2.96283421
3	MP0003195_calcinosis	2.84158372
4	MP0008872_abnormal_physiological_respon	2.53246717
5	MP0002138_abnormal_hepatobiliary_system	2.52712646
6	MP0004145_abnormal_muscle_electrophysio	2.46040771
7	MP0002160_abnormal_reproductive_system	2.40746934
8	MP0002102_abnormal_ear_morphology	2.37964946
9	MP0003646_muscle_fatigue	2.35340836
10	MP0004885_abnormal_endolymph	2.32214270
11	MP0008877_abnormal_DNA_methylation	2.27990331
12	MP0002876_abnormal_thyroid_physiology	2.27469185
13	MP0005551_abnormal_eye_electrophysiolog	2.23822940
14	MP0001485_abnormal_pinna_reflex	2.22202001
15	MP0004134_abnormal_chest_morphology	2.20187546
16	MP0001968_abnormal_touch/_nociception	2.15891640
17	MP0002837_dystrophic_cardiac_calcinosis	2.11545498
18	MP0000631_abnormal_neuroendocrine_gland	2.10190504
19	MP0005389_reproductive_system_phenotype	2.01222182
20	MP0002163_abnormal_gland_morphology	1.93509970
21	MP0006072_abnormal_retinal_apoptosis	1.92854311
22	MP0000049_abnormal_middle_ear	1.86519307
23	MP0002272_abnormal_nervous_system	1.79780631
24	MP0004142_abnormal_muscle_tone	1.77830134
25	MP0003011_delayed_dark_adaptation	1.71008509
26	MP0004133_heterotaxia	1.70394504
27	MP0009745_abnormal_behavioral_response	1.63731937
28	MP0002736_abnormal_nociception_after	1.57585389
29	MP0002735_abnormal_chemical_nociception	1.55587560
30	MP0000372_irregular_coat_pigmentation	1.54878381
31	MP0009046_muscle_twitch	1.49693733
32	MP0005379_endocrine/exocrine_gland_phen	1.48263026
33	MP0005084_abnormal_gallbladder_morpholo	1.45726879
34	MP0005253_abnormal_eye_physiology	1.42611585
35	MP0002938_white_spotting	1.41542717
36	MP0008875_abnormal_xenobiotic_pharmacok	1.41272435
37	MP0001986_abnormal_taste_sensitivity	1.40082580
38	MP0002733_abnormal_thermal_nociception	1.39491114
39	MP0009250_abnormal_appendicular_skeleto	1.36327284
40	MP0002734_abnormal_mechanical_nocicepti	1.32370018
41	MP0002638_abnormal_pupillary_reflex	1.31484972
42	MP0001919_abnormal_reproductive_system	1.27411713
43	MP0001970_abnormal_pain_threshold	1.24969363
44	MP0002064_seizures	1.23866124
45	MP0003638_abnormal_response/metabolism_	1.22832792
46	MP0001486_abnormal_startle_reflex	1.22491268
47	MP0004130_abnormal_muscle_cell	1.20888089
48	MP0000569_abnormal_digit_pigmentation	1.19492005
49	MP0002928_abnormal_bile_duct	1.17176295
50	MP0003787_abnormal_imprinting	1.15566234
51	MP0002277_abnormal_respiratory_mucosa	1.13693400
52	MP0000613_abnormal_salivary_gland	1.13630755
53	MP0002653_abnormal_ependyma_morphology	1.13590043
54	MP0003880_abnormal_central_pattern	1.13500365
55	MP0001440_abnormal_grooming_behavior	1.08360327
56	MP0005174_abnormal_tail_pigmentation	1.06956011
57	MP0005671_abnormal_response_to	1.03626829
58	MP0005083_abnormal_biliary_tract	1.03323732
59	MP0003937_abnormal_limbs/digits/tail_de	1.00952247
60	MP0005195_abnormal_posterior_eye	0.98185697
61	MP0000026_abnormal_inner_ear	0.96478879
62	MP0001963_abnormal_hearing_physiology	0.95162885
63	MP0003938_abnormal_ear_development	0.94274763
64	MP0005645_abnormal_hypothalamus_physiol	0.93854389
65	MP0003119_abnormal_digestive_system	0.92909541
66	MP0003283_abnormal_digestive_organ	0.92476177
67	MP0004742_abnormal_vestibular_system	0.91865079
68	MP0002282_abnormal_trachea_morphology	0.91848483
69	MP0001905_abnormal_dopamine_level	0.89829952
70	MP0004215_abnormal_myocardial_fiber	0.89219347
71	MP0002572_abnormal_emotion/affect_behav	0.87408292
72	MP0009780_abnormal_chondrocyte_physiolo	0.86083084
73	MP0002557_abnormal_social/conspecific_i	0.85687968
74	MP0000230_abnormal_systemic_arterial	0.85356673
75	MP0002752_abnormal_somatic_nervous	0.84866129
76	MP0002139_abnormal_hepatobiliary_system	0.84737936
77	MP0003136_yellow_coat_color	0.82584999
78	MP0003252_abnormal_bile_duct	0.81926309
79	MP0000427_abnormal_hair_cycle	0.79389428
80	MP0006276_abnormal_autonomic_nervous	0.78401148
81	MP0001501_abnormal_sleep_pattern	0.78130127
82	MP0003635_abnormal_synaptic_transmissio	0.77408353
83	MP0002751_abnormal_autonomic_nervous	0.76789239
84	MP0005171_absent_coat_pigmentation	0.76764839
85	MP0002184_abnormal_innervation	0.75785415
86	MP0005410_abnormal_fertilization	0.74382105
87	MP0001529_abnormal_vocalization	0.74358051
88	MP0008995_early_reproductive_senescence	0.73630991
89	MP0010386_abnormal_urinary_bladder	0.73322670
90	MP0002067_abnormal_sensory_capabilities	0.72483820
91	MP0002095_abnormal_skin_pigmentation	0.71828561
92	MP0001984_abnormal_olfaction	0.70002376
93	MP0005360_urolithiasis	0.69645787
94	MP0002063_abnormal_learning/memory/cond	0.69541366
95	MP0000383_abnormal_hair_follicle	0.68983268
96	MP0000678_abnormal_parathyroid_gland	0.68805973
97	MP0001293_anophthalmia	0.65594783
98	MP0004270_analgesia	0.65591408
99	MP0004924_abnormal_behavior	0.64574745
100	MP0005386_behavior/neurological_phenoty	0.64574745

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.44273799
2	Pendular nystagmus (HP:0012043)	4.42984057
3	Pancreatic fibrosis (HP:0100732)	4.29563601
4	True hermaphroditism (HP:0010459)	4.10252382
5	Abolished electroretinogram (ERG) (HP:0000550)	3.99192490
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.62765478
7	Genetic anticipation (HP:0003743)	3.48611860
8	Methylmalonic acidemia (HP:0002912)	3.36412575
9	Keratoconus (HP:0000563)	3.18031957
10	Increased corneal curvature (HP:0100692)	3.18031957
11	Nephronophthisis (HP:0000090)	3.16749211
12	Congenital stationary night blindness (HP:0007642)	3.12788628
13	Abnormality of midbrain morphology (HP:0002418)	3.09985573
14	Molar tooth sign on MRI (HP:0002419)	3.09985573
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.07848796
16	Asplenia (HP:0001746)	3.04294710
17	Decreased central vision (HP:0007663)	3.01200503
18	3-Methylglutaconic aciduria (HP:0003535)	2.98762768
19	Progressive cerebellar ataxia (HP:0002073)	2.97951737
20	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.96776192
21	Congenital, generalized hypertrichosis (HP:0004540)	2.90723817
22	Abnormality of the renal cortex (HP:0011035)	2.82677973
23	Cystic liver disease (HP:0006706)	2.82214913
24	Furrowed tongue (HP:0000221)	2.79062684
25	Severe visual impairment (HP:0001141)	2.77294666
26	Methylmalonic aciduria (HP:0012120)	2.74962219
27	Abnormality of the renal medulla (HP:0100957)	2.67454954
28	Agitation (HP:0000713)	2.61273632
29	Septo-optic dysplasia (HP:0100842)	2.56909328
30	Attenuation of retinal blood vessels (HP:0007843)	2.54597238
31	Confusion (HP:0001289)	2.49900924
32	Sclerocornea (HP:0000647)	2.48679433
33	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.42203221
34	Type II lissencephaly (HP:0007260)	2.41818333
35	Renal cortical cysts (HP:0000803)	2.39058056
36	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.37350102
37	Gaze-evoked nystagmus (HP:0000640)	2.34711387
38	Congenital sensorineural hearing impairment (HP:0008527)	2.34376863
39	Conjunctival hamartoma (HP:0100780)	2.32951387
40	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.26360580
41	Porencephaly (HP:0002132)	2.26244529
42	Hypoplasia of the uterus (HP:0000013)	2.23200075
43	Mitochondrial inheritance (HP:0001427)	2.19907700
44	Chorioretinal atrophy (HP:0000533)	2.19469238
45	Male pseudohermaphroditism (HP:0000037)	2.16351135
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.14456624
47	Small hand (HP:0200055)	2.11664763
48	Abnormality of DNA repair (HP:0003254)	2.11511069
49	Hypoplastic pelvis (HP:0008839)	2.09899338
50	Abnormality of the renal collecting system (HP:0004742)	2.09042551
51	Acute necrotizing encephalopathy (HP:0006965)	2.08908287
52	Chronic hepatic failure (HP:0100626)	2.08828001
53	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.07651174
54	Absent thumb (HP:0009777)	2.07501514
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.07232777
56	Aplasia/hypoplasia of the uterus (HP:0008684)	2.06840662
57	Anencephaly (HP:0002323)	2.06633629
58	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.05558242
59	Medial flaring of the eyebrow (HP:0010747)	2.03638043
60	Congenital hepatic fibrosis (HP:0002612)	2.03313020
61	Abnormality of the nasal septum (HP:0000419)	2.03265089
62	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.02565146
63	Short hallux (HP:0010109)	2.02281286
64	Hemiplegia (HP:0002301)	2.00352499
65	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.99870435
66	Abnormality of homocysteine metabolism (HP:0010919)	1.98931953
67	Homocystinuria (HP:0002156)	1.98931953
68	Increased CSF lactate (HP:0002490)	1.98897826
69	Optic nerve hypoplasia (HP:0000609)	1.98872700
70	Concave nail (HP:0001598)	1.97356113
71	IgG deficiency (HP:0004315)	1.96352569
72	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.96308872
73	Hamartoma of the eye (HP:0010568)	1.95893341
74	Hepatocellular necrosis (HP:0001404)	1.92293935
75	Short tibia (HP:0005736)	1.91831076
76	Progressive macrocephaly (HP:0004481)	1.91615172
77	Abnormality of the middle phalanges of the toes (HP:0010183)	1.91253789
78	Short 1st metacarpal (HP:0010034)	1.89732709
79	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.89732709
80	Hemiparesis (HP:0001269)	1.88725000
81	Tubular atrophy (HP:0000092)	1.87876135
82	Abnormality of vitamin B metabolism (HP:0004340)	1.84739468
83	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.84050325
84	Thyroiditis (HP:0100646)	1.82089383
85	Goiter (HP:0000853)	1.81525214
86	Abnormality of chromosome stability (HP:0003220)	1.78805085
87	Abnormal mitochondria in muscle tissue (HP:0008316)	1.78795093
88	Hypoplasia of the pons (HP:0012110)	1.78348695
89	Abnormality of the pons (HP:0007361)	1.77306241
90	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76062579
91	Abnormality of alanine metabolism (HP:0010916)	1.76062579
92	Hyperalaninemia (HP:0003348)	1.76062579
93	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.75732007
94	Postaxial foot polydactyly (HP:0001830)	1.75408851
95	Abnormality of the ileum (HP:0001549)	1.72527197
96	Morphological abnormality of the middle ear (HP:0008609)	1.72062065
97	Meckel diverticulum (HP:0002245)	1.70269215
98	Acute encephalopathy (HP:0006846)	1.69621886
99	Hepatic necrosis (HP:0002605)	1.69189525
100	Genital tract atresia (HP:0001827)	1.68476587

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.75437322
2	ADRBK2	4.06985949
3	GRK1	3.89748700
4	PINK1	2.93202923
5	MAP4K2	2.79728652
6	TLK1	2.68745511
7	NUAK1	2.63028101
8	ZAK	2.62066629
9	TAOK3	2.47359340
10	BMPR1B	2.35810687
11	TXK	2.03452565
12	WNK3	1.98798635
13	VRK2	1.78144470
14	ACVR1B	1.75227939
15	INSRR	1.60880265
16	WNK4	1.52080739
17	VRK1	1.51521982
18	MAPK13	1.46380104
19	TAF1	1.40262349
20	PRKD2	1.39774331
21	MST4	1.38985672
22	TNIK	1.32513545
23	STK16	1.30288869
24	DAPK2	1.27297511
25	OXSR1	1.22975910
26	TIE1	1.18271402
27	CASK	1.13678195
28	MAP3K4	1.11330850
29	ADRBK1	1.07596514
30	CSNK1G1	1.04022814
31	IKBKB	1.02985051
32	STK39	1.02468819
33	DYRK2	1.00967827
34	PAK3	0.98144803
35	GRK7	0.96721543
36	PLK2	0.96634265
37	GRK6	0.95456706
38	PRKCG	0.94892510
39	CSNK1G2	0.92406239
40	CSNK1G3	0.90243218
41	PRKCE	0.90080916
42	PTK2B	0.89701080
43	MUSK	0.88202323
44	NME1	0.84718566
45	TEC	0.84374573
46	MAPKAPK3	0.83253335
47	GRK5	0.82437306
48	BCKDK	0.76945757
49	TRIM28	0.76565616
50	CSNK1A1L	0.76421132
51	RPS6KA5	0.73095996
52	MAP2K6	0.69317909
53	CDC7	0.67572270
54	CAMKK2	0.67524698
55	PHKG2	0.67244021
56	PHKG1	0.67244021
57	CSNK1A1	0.65380526
58	MAP2K7	0.63652938
59	PRKCI	0.63437338
60	MAPKAPK5	0.62974723
61	BRSK2	0.61271617
62	PRKCQ	0.59226383
63	PIK3CA	0.58079454
64	EIF2AK3	0.55908289
65	PRKACA	0.54319869
66	PKN1	0.54297681
67	FGFR2	0.53397505
68	CAMK2A	0.53072881
69	MKNK2	0.52713563
70	KIT	0.51195216
71	BLK	0.48557803
72	FLT3	0.48015093
73	ITK	0.46728479
74	MAP2K2	0.45471800
75	NTRK2	0.44501686
76	ERBB2	0.44234824
77	PRKCA	0.43435572
78	CAMK1	0.43353353
79	IGF1R	0.43217266
80	PLK3	0.43148938
81	PLK4	0.42990994
82	SYK	0.41214230
83	NLK	0.40303717
84	PIM1	0.40236178
85	PRKCH	0.40229118
86	OBSCN	0.39829881
87	CHUK	0.39423218
88	ABL1	0.38631010
89	STK38L	0.38361241
90	MAP3K9	0.37501178
91	MAPK15	0.35959279
92	SGK2	0.35710862
93	CSNK1D	0.35467334
94	STK11	0.34589293
95	CDK8	0.34370914
96	LYN	0.34072304
97	STK3	0.33797826
98	NTRK3	0.33258610
99	EIF2AK2	0.32395372
100	ATR	0.32010157

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.87065857
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.76679872
3	Phototransduction_Homo sapiens_hsa04744	2.54097010
4	Homologous recombination_Homo sapiens_hsa03440	2.40048500
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.36179886
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.31957162
7	Nicotine addiction_Homo sapiens_hsa05033	2.19047314
8	Parkinsons disease_Homo sapiens_hsa05012	2.09662276
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.08606508
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.00276295
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.96553162
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.90480299
13	Sulfur metabolism_Homo sapiens_hsa00920	1.86563131
14	Caffeine metabolism_Homo sapiens_hsa00232	1.80880632
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.78614560
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77302900
17	Protein export_Homo sapiens_hsa03060	1.71876020
18	RNA polymerase_Homo sapiens_hsa03020	1.68948431
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.68718763
20	Chemical carcinogenesis_Homo sapiens_hsa05204	1.67533978
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.56609311
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55867140
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.53397459
24	Alzheimers disease_Homo sapiens_hsa05010	1.46893187
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45970246
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.45216806
27	Taste transduction_Homo sapiens_hsa04742	1.42830877
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.42551404
29	Basal transcription factors_Homo sapiens_hsa03022	1.40445474
30	Morphine addiction_Homo sapiens_hsa05032	1.39722680
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.34585815
32	Ribosome_Homo sapiens_hsa03010	1.31649949
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.30820208
34	Huntingtons disease_Homo sapiens_hsa05016	1.29524615
35	Retinol metabolism_Homo sapiens_hsa00830	1.26820460
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.26451530
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.25881382
38	Asthma_Homo sapiens_hsa05310	1.20375181
39	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.15800603
40	RNA degradation_Homo sapiens_hsa03018	1.15747041
41	Olfactory transduction_Homo sapiens_hsa04740	1.13240479
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.10566257
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.08730974
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.08456625
45	Butanoate metabolism_Homo sapiens_hsa00650	1.06347265
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.06273655
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.03553627
48	One carbon pool by folate_Homo sapiens_hsa00670	1.00934461
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00442456
50	Insulin secretion_Homo sapiens_hsa04911	0.96824327
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.93775285
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.90948849
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88779659
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.88357448
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.86077097
56	GABAergic synapse_Homo sapiens_hsa04727	0.84948660
57	Serotonergic synapse_Homo sapiens_hsa04726	0.83813685
58	Melanoma_Homo sapiens_hsa05218	0.83468473
59	Circadian entrainment_Homo sapiens_hsa04713	0.81267156
60	Peroxisome_Homo sapiens_hsa04146	0.80091435
61	Proteasome_Homo sapiens_hsa03050	0.79992928
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.79004122
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73451080
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.73439079
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.73103523
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.71751305
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70311385
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69367360
69	Salivary secretion_Homo sapiens_hsa04970	0.67861526
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66394032
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.63584264
72	Purine metabolism_Homo sapiens_hsa00230	0.63170380
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.62973098
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62070918
75	Type I diabetes mellitus_Homo sapiens_hsa04940	0.57852168
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56235124
77	ABC transporters_Homo sapiens_hsa02010	0.56162464
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55980993
79	Graft-versus-host disease_Homo sapiens_hsa05332	0.55444711
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54939444
81	Regulation of autophagy_Homo sapiens_hsa04140	0.54123328
82	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.53746036
83	Renin secretion_Homo sapiens_hsa04924	0.53565936
84	Allograft rejection_Homo sapiens_hsa05330	0.51441777
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48761483
86	Metabolic pathways_Homo sapiens_hsa01100	0.47126847
87	Histidine metabolism_Homo sapiens_hsa00340	0.46825733
88	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.46030211
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45618339
90	Propanoate metabolism_Homo sapiens_hsa00640	0.45039506
91	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.42908770
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42811821
93	DNA replication_Homo sapiens_hsa03030	0.42116703
94	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.41842069
95	Mineral absorption_Homo sapiens_hsa04978	0.41204778
96	Rheumatoid arthritis_Homo sapiens_hsa05323	0.41007888
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40718158
98	Sulfur relay system_Homo sapiens_hsa04122	0.38546349
99	Alcoholism_Homo sapiens_hsa05034	0.38367975
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.36378331

MTHFD2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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