MTHFD2P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)7.67881906
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.98938763
3DNA deamination (GO:0045006)5.91821807
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.31931698
5regulation of isotype switching to IgG isotypes (GO:0048302)5.00722756
6rRNA modification (GO:0000154)4.79223371
7cytidine metabolic process (GO:0046087)4.68468276
8cytidine catabolic process (GO:0006216)4.68468276
9cytidine deamination (GO:0009972)4.68468276
10proteasome assembly (GO:0043248)4.60944492
11protein complex biogenesis (GO:0070271)4.53402957
12water-soluble vitamin biosynthetic process (GO:0042364)4.52429529
13mitochondrial respiratory chain complex assembly (GO:0033108)4.48046803
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.45697651
15regulation of cellular amino acid metabolic process (GO:0006521)4.40424029
16folic acid-containing compound biosynthetic process (GO:0009396)4.37831020
17termination of RNA polymerase I transcription (GO:0006363)4.35282196
18rRNA methylation (GO:0031167)4.29458039
19NADH dehydrogenase complex assembly (GO:0010257)4.26797946
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.26797946
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.26797946
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.18336445
23transcription elongation from RNA polymerase I promoter (GO:0006362)4.13152254
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.12462234
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.12462234
26CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.11415007
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.07250678
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.98677863
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.98234469
30intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.98234469
31signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.95657842
32signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.95657842
33signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.95657842
34negative regulation of ligase activity (GO:0051352)3.95026198
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.95026198
36chaperone-mediated protein transport (GO:0072321)3.93435775
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.90114920
38maturation of SSU-rRNA (GO:0030490)3.89386823
39signal transduction involved in DNA integrity checkpoint (GO:0072401)3.81807799
40signal transduction involved in DNA damage checkpoint (GO:0072422)3.81807799
41positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.80169183
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.77378500
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.77124619
44energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75256925
45ATP synthesis coupled proton transport (GO:0015986)3.75256925
46signal transduction involved in cell cycle checkpoint (GO:0072395)3.74518959
47pseudouridine synthesis (GO:0001522)3.67947323
48positive regulation of humoral immune response (GO:0002922)3.66509053
49ribosome assembly (GO:0042255)3.65353065
50tRNA aminoacylation (GO:0043039)3.56812749
51amino acid activation (GO:0043038)3.56812749
52GTP biosynthetic process (GO:0006183)3.55792171
53cullin deneddylation (GO:0010388)3.53107660
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.51985659
55pteridine-containing compound biosynthetic process (GO:0042559)3.51646395
56protein deneddylation (GO:0000338)3.50869536
57cytokine production involved in immune response (GO:0002367)3.50568317
58negative regulation of T-helper cell differentiation (GO:0045623)3.49811399
59negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.49811399
60antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.49754960
61protein neddylation (GO:0045116)3.45557530
62positive regulation of B cell mediated immunity (GO:0002714)3.44994853
63positive regulation of immunoglobulin mediated immune response (GO:0002891)3.44994853
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42974212
65tRNA aminoacylation for protein translation (GO:0006418)3.41572841
66positive regulation of ligase activity (GO:0051351)3.40934968
67positive regulation of DNA recombination (GO:0045911)3.39406024
68respiratory chain complex IV assembly (GO:0008535)3.38142936
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.37491450
70nucleobase biosynthetic process (GO:0046112)3.35362512
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34749666
72UTP biosynthetic process (GO:0006228)3.33475482
73positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.27996398
74regulation of immunoglobulin secretion (GO:0051023)3.27721084
75positive regulation of isotype switching (GO:0045830)3.23441650
76intracellular protein transmembrane import (GO:0044743)3.22554135
77positive regulation of cell cycle arrest (GO:0071158)3.20980209
78transcription initiation from RNA polymerase I promoter (GO:0006361)3.19113981
79transcription from RNA polymerase I promoter (GO:0006360)3.16768782
80maturation of 5.8S rRNA (GO:0000460)3.14444032
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13959376
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13138674
83positive regulation of immunoglobulin production (GO:0002639)3.12855254
84DNA catabolic process, exonucleolytic (GO:0000738)3.10069303
85tRNA metabolic process (GO:0006399)3.10015883
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09192222
87regulation of cellular amine metabolic process (GO:0033238)3.08237198
88cytochrome complex assembly (GO:0017004)3.06846265
89regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.05363117
90signal peptide processing (GO:0006465)3.04946178
91regulation of ubiquitin-protein transferase activity (GO:0051438)3.01776752
92DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.99755749
93UTP metabolic process (GO:0046051)2.96370171
94T-helper cell differentiation (GO:0042093)2.95621711
95CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.95621711
96regulation of regulatory T cell differentiation (GO:0045589)2.94906338
97regulation of ligase activity (GO:0051340)2.94724711
98antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.92134698
99negative regulation of protein ubiquitination (GO:0031397)2.91359684
100mismatch repair (GO:0006298)2.90034547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human6.18855929
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.23827013
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.60109628
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.17060506
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.60616040
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.40322576
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.24878147
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16602389
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88717083
10VDR_23849224_ChIP-Seq_CD4+_Human2.87212243
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.76458690
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71504986
13ELK1_19687146_ChIP-ChIP_HELA_Human2.68607174
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65750853
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59760563
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.49767495
17FOXP3_21729870_ChIP-Seq_TREG_Human2.43729791
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43707641
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.10109035
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05232828
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02122271
22DCP1A_22483619_ChIP-Seq_HELA_Human1.95371490
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93655606
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92212949
25VDR_22108803_ChIP-Seq_LS180_Human1.89794934
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.87457244
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84016214
28E2F7_22180533_ChIP-Seq_HELA_Human1.83742572
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.76319750
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75874191
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.75794529
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75268113
33TTF2_22483619_ChIP-Seq_HELA_Human1.70520001
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.67035940
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67008485
36EWS_26573619_Chip-Seq_HEK293_Human1.65441654
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65032907
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62559795
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62188169
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61460184
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60419106
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60037451
43GABP_19822575_ChIP-Seq_HepG2_Human1.59895803
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54168094
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50268518
46XRN2_22483619_ChIP-Seq_HELA_Human1.50235627
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48791729
48MYC_18940864_ChIP-ChIP_HL60_Human1.46942461
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45282913
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45035304
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34793974
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32728085
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32211435
54TP53_22573176_ChIP-Seq_HFKS_Human1.32054565
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31104300
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29258508
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.29210162
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28773975
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22100433
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21056487
61GATA3_26560356_Chip-Seq_TH2_Human1.17147455
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16806983
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15083510
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.11609756
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09810935
66MYB_26560356_Chip-Seq_TH2_Human1.09569312
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08400881
68CIITA_25753668_ChIP-Seq_RAJI_Human1.04480028
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01608171
70KDM5A_27292631_Chip-Seq_BREAST_Human1.01503554
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00083292
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00083292
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00083292
74NFE2_27457419_Chip-Seq_LIVER_Mouse0.98827039
75SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98749783
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97579343
77ELF5_23300383_ChIP-Seq_T47D_Human0.96849723
78ZNF274_21170338_ChIP-Seq_K562_Hela0.96777892
79IRF8_22096565_ChIP-ChIP_GC-B_Human0.95493934
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92326924
81SOX2_19829295_ChIP-Seq_ESCs_Human0.92102154
82NANOG_19829295_ChIP-Seq_ESCs_Human0.92102154
83MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90855899
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90003291
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88441711
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88240748
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87390218
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.87390218
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87240929
90E2F1_21310950_ChIP-Seq_MCF-7_Human0.85555583
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84226306
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84195188
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83409773
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82349901
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81348271
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81027573
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80027713
98LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79722182
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.78271219
100SALL4_22934838_ChIP-ChIP_CD34+_Human0.78190243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland4.85616759
2MP0001873_stomach_inflammation4.29630958
3MP0000685_abnormal_immune_system4.24743244
4MP0001835_abnormal_antigen_presentation3.99343650
5MP0004147_increased_porphyrin_level3.88927790
6MP0002138_abnormal_hepatobiliary_system3.20423123
7MP0005671_abnormal_response_to3.13067300
8MP0002166_altered_tumor_susceptibility2.92929927
9MP0001790_abnormal_immune_system2.71982704
10MP0005387_immune_system_phenotype2.71982704
11MP0003718_maternal_effect2.54958621
12MP0002006_tumorigenesis2.26782020
13MP0003646_muscle_fatigue2.16446688
14MP0003763_abnormal_thymus_physiology2.14643658
15MP0009785_altered_susceptibility_to2.10937486
16MP0008872_abnormal_physiological_respon2.08808034
17MP0002277_abnormal_respiratory_mucosa2.08413413
18MP0008058_abnormal_DNA_repair1.88708428
19MP0002736_abnormal_nociception_after1.85949956
20MP0008875_abnormal_xenobiotic_pharmacok1.85793235
21MP0001800_abnormal_humoral_immune1.82678593
22MP0009333_abnormal_splenocyte_physiolog1.78707977
23MP0002148_abnormal_hypersensitivity_rea1.76605061
24MP0006082_CNS_inflammation1.74947475
25MP0003786_premature_aging1.63520116
26MP0005377_hearing/vestibular/ear_phenot1.62988068
27MP0003878_abnormal_ear_physiology1.62988068
28MP0003693_abnormal_embryo_hatching1.59482013
29MP0004957_abnormal_blastocyst_morpholog1.58734729
30MP0005645_abnormal_hypothalamus_physiol1.58294754
31MP0003866_abnormal_defecation1.56625035
32MP0005084_abnormal_gallbladder_morpholo1.55816093
33MP0002405_respiratory_system_inflammati1.50729600
34MP0003567_abnormal_fetal_cardiomyocyte1.47866593
35MP0002163_abnormal_gland_morphology1.47448716
36MP0001501_abnormal_sleep_pattern1.44744505
37MP0003011_delayed_dark_adaptation1.42218914
38MP0005379_endocrine/exocrine_gland_phen1.38275577
39MP0006036_abnormal_mitochondrial_physio1.36693275
40MP0003186_abnormal_redox_activity1.36654951
41MP0002102_abnormal_ear_morphology1.36271313
42MP0002837_dystrophic_cardiac_calcinosis1.34498680
43MP0003806_abnormal_nucleotide_metabolis1.31187117
44MP0001968_abnormal_touch/_nociception1.28374532
45MP0005636_abnormal_mineral_homeostasis1.26961791
46MP0008877_abnormal_DNA_methylation1.26912709
47MP0005310_abnormal_salivary_gland1.24720302
48MP0002723_abnormal_immune_serum1.23349114
49MP0005408_hypopigmentation1.21409370
50MP0002254_reproductive_system_inflammat1.18946760
51MP0000703_abnormal_thymus_morphology1.17977897
52MP0005000_abnormal_immune_tolerance1.17019973
53MP0005025_abnormal_response_to1.11469997
54MP0003045_fibrosis1.10859219
55MP0006072_abnormal_retinal_apoptosis1.09187998
56MP0004782_abnormal_surfactant_physiolog1.06257920
57MP0010094_abnormal_chromosome_stability1.06192838
58MP0002420_abnormal_adaptive_immunity1.01470054
59MP0002398_abnormal_bone_marrow0.99444603
60MP0001819_abnormal_immune_cell0.96724190
61MP0001845_abnormal_inflammatory_respons0.96065610
62MP0000689_abnormal_spleen_morphology0.95834550
63MP0003077_abnormal_cell_cycle0.95560935
64MP0002452_abnormal_antigen_presenting0.93876953
65MP0000716_abnormal_immune_system0.93501740
66MP0004142_abnormal_muscle_tone0.90687472
67MP0006035_abnormal_mitochondrial_morpho0.89818055
68MP0005584_abnormal_enzyme/coenzyme_acti0.89291163
69MP0004084_abnormal_cardiac_muscle0.88648093
70MP0006054_spinal_hemorrhage0.88287868
71MP0004742_abnormal_vestibular_system0.87743971
72MP0008057_abnormal_DNA_replication0.87298263
73MP0003436_decreased_susceptibility_to0.86893819
74MP0004043_abnormal_pH_regulation0.85708938
75MP0005395_other_phenotype0.84252881
76MP0001663_abnormal_digestive_system0.84033290
77MP0002653_abnormal_ependyma_morphology0.83879069
78MP0002938_white_spotting0.83811997
79MP0009764_decreased_sensitivity_to0.82133692
80MP0010155_abnormal_intestine_physiology0.81279703
81MP0002429_abnormal_blood_cell0.81200256
82MP0002722_abnormal_immune_system0.80363844
83MP0003195_calcinosis0.79892357
84MP0004215_abnormal_myocardial_fiber0.79726822
85MP0005165_increased_susceptibility_to0.79183860
86MP0000490_abnormal_crypts_of0.77347584
87MP0005332_abnormal_amino_acid0.74848195
88MP0003111_abnormal_nucleus_morphology0.74634485
89MP0001919_abnormal_reproductive_system0.74568817
90MP0001853_heart_inflammation0.73016786
91MP0000627_abnormal_mammary_gland0.72450092
92MP0005551_abnormal_eye_electrophysiolog0.72265698
93MP0001119_abnormal_female_reproductive0.72027477
94MP0003936_abnormal_reproductive_system0.70787939
95MP0001529_abnormal_vocalization0.70533257
96MP0001485_abnormal_pinna_reflex0.69593475
97MP0008469_abnormal_protein_level0.68987730
98MP0005167_abnormal_blood-brain_barrier0.67504459
99MP0003959_abnormal_lean_body0.67259985
100MP0001188_hyperpigmentation0.66453860

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)5.13187384
2Acute necrotizing encephalopathy (HP:0006965)4.60535654
3Lipid accumulation in hepatocytes (HP:0006561)4.48084846
4Mitochondrial inheritance (HP:0001427)4.35122035
5Increased CSF lactate (HP:0002490)4.34094089
6Acute encephalopathy (HP:0006846)4.29297977
7Hypoplasia of the pons (HP:0012110)4.22290559
8Abnormality of the pons (HP:0007361)4.18978210
9Progressive macrocephaly (HP:0004481)4.08912646
10Abnormal mitochondria in muscle tissue (HP:0008316)3.86471998
11Conjunctival hamartoma (HP:0100780)3.85316276
12Renal Fanconi syndrome (HP:0001994)3.64078703
13Hepatocellular necrosis (HP:0001404)3.53891984
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.44742189
15Aplastic anemia (HP:0001915)3.35125608
16Hepatic necrosis (HP:0002605)3.29055849
17IgG deficiency (HP:0004315)3.24473938
18Increased serum pyruvate (HP:0003542)3.22353219
19Exertional dyspnea (HP:0002875)3.16782262
20Increased serum lactate (HP:0002151)3.11847660
21Abnormality of glycolysis (HP:0004366)3.07253371
22Cerebral edema (HP:0002181)3.03365651
23Increased intramyocellular lipid droplets (HP:0012240)3.02349636
24Methylmalonic acidemia (HP:0002912)2.82721799
25Cerebral hemorrhage (HP:0001342)2.82461931
26Respiratory difficulties (HP:0002880)2.77056402
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73594996
28Palpitations (HP:0001962)2.73523986
29Increased IgM level (HP:0003496)2.66485079
30Cavernous hemangioma (HP:0001048)2.65119668
31Optic disc pallor (HP:0000543)2.58535192
32Exercise intolerance (HP:0003546)2.57060664
33Pheochromocytoma (HP:0002666)2.56392461
34Leukodystrophy (HP:0002415)2.55936886
35Neuroendocrine neoplasm (HP:0100634)2.54323489
36Hyperphosphaturia (HP:0003109)2.53373552
37Methylmalonic aciduria (HP:0012120)2.52272203
38Stomatitis (HP:0010280)2.52161331
39Pancytopenia (HP:0001876)2.51925355
40Testicular atrophy (HP:0000029)2.50592420
41Lactic acidosis (HP:0003128)2.48251021
42Microvesicular hepatic steatosis (HP:0001414)2.46339659
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39203839
44Abnormality of alanine metabolism (HP:0010916)2.39203839
45Hyperalaninemia (HP:0003348)2.39203839
46Cleft eyelid (HP:0000625)2.35227351
47Increased muscle lipid content (HP:0009058)2.33254358
48Elevated erythrocyte sedimentation rate (HP:0003565)2.32272313
49Pancreatic cysts (HP:0001737)2.29127844
50Renal cortical cysts (HP:0000803)2.24820469
51Meckel diverticulum (HP:0002245)2.23557627
52Abnormality of urine glucose concentration (HP:0011016)2.20915126
53Glycosuria (HP:0003076)2.20915126
54Hamartoma of the eye (HP:0010568)2.20779236
55Neoplasm of the adrenal gland (HP:0100631)2.20241536
56Lethargy (HP:0001254)2.16920815
57Progressive microcephaly (HP:0000253)2.16697499
583-Methylglutaconic aciduria (HP:0003535)2.16647374
59Abnormality of the ileum (HP:0001549)2.14814896
60Autoimmune hemolytic anemia (HP:0001890)2.13943508
61Respiratory failure (HP:0002878)2.12315576
62Abnormality of T cells (HP:0002843)2.11875518
63Congenital stationary night blindness (HP:0007642)2.09522608
64Angiofibromas (HP:0010615)2.07830363
65Adenoma sebaceum (HP:0009720)2.07830363
66Cellular immunodeficiency (HP:0005374)2.07671509
67Type I transferrin isoform profile (HP:0003642)2.04086398
68Recurrent cutaneous fungal infections (HP:0011370)2.03609998
69Chronic mucocutaneous candidiasis (HP:0002728)2.03609998
70Pigmentary retinal degeneration (HP:0001146)2.00827342
71Abnormality of T cell physiology (HP:0011840)2.00211529
72Aplasia/Hypoplasia of the ulna (HP:0006495)1.94777918
73Aplasia/Hypoplasia of the uvula (HP:0010293)1.94541095
74Dyschromatopsia (HP:0007641)1.94428195
75Abnormality of renal resorption (HP:0011038)1.93742401
76Oral leukoplakia (HP:0002745)1.92742495
77Abnormal delayed hypersensitivity skin test (HP:0002963)1.90722432
78Paralysis (HP:0003470)1.89562806
79Forearm undergrowth (HP:0009821)1.88245664
80Hypoplasia of the ulna (HP:0003022)1.87484462
81Nausea (HP:0002018)1.87102430
82Aplasia/hypoplasia of the uterus (HP:0008684)1.87014557
83Pendular nystagmus (HP:0012043)1.86571050
84Abnormal albumin level (HP:0012116)1.85277286
85Hypoalbuminemia (HP:0003073)1.85277286
86Molar tooth sign on MRI (HP:0002419)1.81861971
87Abnormality of midbrain morphology (HP:0002418)1.81861971
88Congenital, generalized hypertrichosis (HP:0004540)1.81782995
89Abnormality of the renal cortex (HP:0011035)1.81400962
90Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.81118604
91Encephalitis (HP:0002383)1.80300211
92T lymphocytopenia (HP:0005403)1.80195637
93Disproportionate short-trunk short stature (HP:0003521)1.79966004
94Abnormal urine phosphate concentration (HP:0012599)1.79792592
95Abnormality of placental membranes (HP:0011409)1.79677538
96Amniotic constriction ring (HP:0009775)1.79677538
97Metaphyseal dysplasia (HP:0100255)1.79564942
98Delayed CNS myelination (HP:0002188)1.79228615
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77870154
100Meningioma (HP:0002858)1.73700941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.81016154
2MST44.67182838
3TSSK64.50775410
4EIF2AK13.86408667
5VRK23.75082039
6EIF2AK33.61184274
7TRIM283.40957516
8PBK3.38389290
9BUB13.32773657
10TAF13.07990565
11SRPK12.62142761
12NUAK12.58806954
13NME12.37334303
14MAP4K12.12957666
15SIK32.12195768
16VRK11.90568487
17ADRBK21.76190757
18PLK31.45321295
19PLK41.44312387
20EIF2AK21.40960713
21TLK11.39176401
22AKT31.29022541
23PASK1.28186942
24WNK41.24094889
25GRK71.17196458
26LATS11.15261776
27MAP3K121.12918783
28GRK11.08429126
29TNIK1.06693966
30NEK11.00376000
31TAOK30.99036007
32FRK0.98401934
33NME20.97629654
34PLK20.93650690
35CDK80.92815776
36DYRK20.92696504
37STK30.90059868
38NEK90.86702606
39DAPK10.85414288
40MAPKAPK30.83712093
41STK390.82805181
42NLK0.78934212
43STK40.69442256
44BCR0.66813326
45ZAK0.65770904
46MAP2K60.65676891
47SCYL20.65135913
48ALK0.63973186
49BCKDK0.63267755
50OXSR10.59769038
51WEE10.58767470
52IKBKB0.55713690
53DAPK20.55629739
54IRAK40.53368861
55CLK10.49985446
56FGFR40.45313432
57TYK20.42990572
58SGK20.41799696
59PLK10.41750830
60FGFR10.41742939
61TGFBR10.41067884
62CSNK2A20.40410036
63ATR0.38627961
64EPHA30.36229680
65PIK3CG0.36030423
66KDR0.35382523
67RPS6KA50.35154006
68TIE10.33845823
69INSRR0.33604162
70CSNK1A1L0.33252693
71PHKG10.32973596
72PHKG20.32973596
73SYK0.32303553
74CSNK2A10.31377602
75WNK10.31093157
76MAPKAPK50.30849414
77TESK20.30257332
78PAK40.29652102
79MYLK0.28994078
80IKBKE0.28717252
81FGFR30.27772895
82RPS6KA40.26674787
83ADRBK10.25542147
84HIPK20.25373356
85LCK0.25278577
86CAMK2A0.24575312
87FES0.24298031
88BMPR1B0.24142954
89MAP4K20.22533716
90CAMK40.22475985
91CDC70.21049846
92DAPK30.20726663
93SGK2230.20648742
94SGK4940.20648742
95PRKCG0.20572020
96KIT0.20368094
97IGF1R0.19833986
98CSNK1G10.19583540
99MKNK20.19215828
100ITK0.19148507

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.92781243
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.82788605
3Protein export_Homo sapiens_hsa030603.55815938
4RNA polymerase_Homo sapiens_hsa030203.04346509
5Oxidative phosphorylation_Homo sapiens_hsa001902.99416536
6Asthma_Homo sapiens_hsa053102.94947206
7One carbon pool by folate_Homo sapiens_hsa006702.85099858
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.60807388
9Parkinsons disease_Homo sapiens_hsa050122.44135043
10Ribosome_Homo sapiens_hsa030102.22455103
11RNA degradation_Homo sapiens_hsa030182.08106873
12Basal transcription factors_Homo sapiens_hsa030222.00673945
13Mismatch repair_Homo sapiens_hsa034301.89569647
14Huntingtons disease_Homo sapiens_hsa050161.78034771
15RNA transport_Homo sapiens_hsa030131.71580137
16Allograft rejection_Homo sapiens_hsa053301.69327859
17Autoimmune thyroid disease_Homo sapiens_hsa053201.68379189
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65301330
19Homologous recombination_Homo sapiens_hsa034401.63861814
20Nucleotide excision repair_Homo sapiens_hsa034201.63164892
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.62518875
22Sulfur metabolism_Homo sapiens_hsa009201.56920257
23Pyrimidine metabolism_Homo sapiens_hsa002401.56107565
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53727768
25Alzheimers disease_Homo sapiens_hsa050101.50795948
26Primary immunodeficiency_Homo sapiens_hsa053401.49373345
27Vitamin B6 metabolism_Homo sapiens_hsa007501.45389675
28Antigen processing and presentation_Homo sapiens_hsa046121.42566235
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39043507
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36656455
31DNA replication_Homo sapiens_hsa030301.33593906
32Spliceosome_Homo sapiens_hsa030401.32789161
33Fanconi anemia pathway_Homo sapiens_hsa034601.31098948
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24082105
35Type I diabetes mellitus_Homo sapiens_hsa049401.24004649
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18737450
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13094642
38Propanoate metabolism_Homo sapiens_hsa006401.12149462
39Hematopoietic cell lineage_Homo sapiens_hsa046401.05265022
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04440253
41Purine metabolism_Homo sapiens_hsa002301.03561490
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.02828404
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95112790
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.92149839
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89740332
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87894070
47Measles_Homo sapiens_hsa051620.85027899
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.83774073
49Steroid biosynthesis_Homo sapiens_hsa001000.80764083
50Caffeine metabolism_Homo sapiens_hsa002320.79591275
51T cell receptor signaling pathway_Homo sapiens_hsa046600.75343024
52Collecting duct acid secretion_Homo sapiens_hsa049660.70454147
53Biosynthesis of amino acids_Homo sapiens_hsa012300.68962016
54Sulfur relay system_Homo sapiens_hsa041220.68036966
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.65545991
56Phototransduction_Homo sapiens_hsa047440.62200939
57Base excision repair_Homo sapiens_hsa034100.61590902
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60935992
59Epstein-Barr virus infection_Homo sapiens_hsa051690.59138927
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57618298
61Non-homologous end-joining_Homo sapiens_hsa034500.57164730
62Cardiac muscle contraction_Homo sapiens_hsa042600.56715718
63Peroxisome_Homo sapiens_hsa041460.56596203
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56201641
65Linoleic acid metabolism_Homo sapiens_hsa005910.55932983
66Metabolic pathways_Homo sapiens_hsa011000.55012247
67Folate biosynthesis_Homo sapiens_hsa007900.54620375
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50139017
69Carbon metabolism_Homo sapiens_hsa012000.50062383
70Fatty acid degradation_Homo sapiens_hsa000710.47522192
71Mineral absorption_Homo sapiens_hsa049780.47057404
72Vitamin digestion and absorption_Homo sapiens_hsa049770.45341690
73Butanoate metabolism_Homo sapiens_hsa006500.44831147
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39962657
75Nitrogen metabolism_Homo sapiens_hsa009100.39459299
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38957065
77Regulation of autophagy_Homo sapiens_hsa041400.38346128
78Pyruvate metabolism_Homo sapiens_hsa006200.37167818
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36915833
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35732095
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34924049
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34275856
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32951919
84Tryptophan metabolism_Homo sapiens_hsa003800.31251511
85Graft-versus-host disease_Homo sapiens_hsa053320.31233464
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29436351
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26243050
88Retinol metabolism_Homo sapiens_hsa008300.25490938
89Fructose and mannose metabolism_Homo sapiens_hsa000510.24999018
90Glutathione metabolism_Homo sapiens_hsa004800.24369970
91Cell cycle_Homo sapiens_hsa041100.23058020
92Rheumatoid arthritis_Homo sapiens_hsa053230.22581609
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22502909
94Arginine and proline metabolism_Homo sapiens_hsa003300.22213264
95mRNA surveillance pathway_Homo sapiens_hsa030150.19421024
96Arginine biosynthesis_Homo sapiens_hsa002200.17934374
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.17910415
98HTLV-I infection_Homo sapiens_hsa051660.17436137
99Ether lipid metabolism_Homo sapiens_hsa005650.16173313
100beta-Alanine metabolism_Homo sapiens_hsa004100.15964238

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