

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of chronic inflammatory response (GO:0002676) | 7.67881906 |
| 2 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.98938763 |
| 3 | DNA deamination (GO:0045006) | 5.91821807 |
| 4 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.31931698 |
| 5 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.00722756 |
| 6 | rRNA modification (GO:0000154) | 4.79223371 |
| 7 | cytidine metabolic process (GO:0046087) | 4.68468276 |
| 8 | cytidine catabolic process (GO:0006216) | 4.68468276 |
| 9 | cytidine deamination (GO:0009972) | 4.68468276 |
| 10 | proteasome assembly (GO:0043248) | 4.60944492 |
| 11 | protein complex biogenesis (GO:0070271) | 4.53402957 |
| 12 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.52429529 |
| 13 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.48046803 |
| 14 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.45697651 |
| 15 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.40424029 |
| 16 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.37831020 |
| 17 | termination of RNA polymerase I transcription (GO:0006363) | 4.35282196 |
| 18 | rRNA methylation (GO:0031167) | 4.29458039 |
| 19 | NADH dehydrogenase complex assembly (GO:0010257) | 4.26797946 |
| 20 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.26797946 |
| 21 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.26797946 |
| 22 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.18336445 |
| 23 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 4.13152254 |
| 24 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.12462234 |
| 25 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.12462234 |
| 26 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 4.11415007 |
| 27 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.07250678 |
| 28 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.98677863 |
| 29 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.98234469 |
| 30 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.98234469 |
| 31 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.95657842 |
| 32 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.95657842 |
| 33 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.95657842 |
| 34 | negative regulation of ligase activity (GO:0051352) | 3.95026198 |
| 35 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.95026198 |
| 36 | chaperone-mediated protein transport (GO:0072321) | 3.93435775 |
| 37 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.90114920 |
| 38 | maturation of SSU-rRNA (GO:0030490) | 3.89386823 |
| 39 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.81807799 |
| 40 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.81807799 |
| 41 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.80169183 |
| 42 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.77378500 |
| 43 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.77124619 |
| 44 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.75256925 |
| 45 | ATP synthesis coupled proton transport (GO:0015986) | 3.75256925 |
| 46 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.74518959 |
| 47 | pseudouridine synthesis (GO:0001522) | 3.67947323 |
| 48 | positive regulation of humoral immune response (GO:0002922) | 3.66509053 |
| 49 | ribosome assembly (GO:0042255) | 3.65353065 |
| 50 | tRNA aminoacylation (GO:0043039) | 3.56812749 |
| 51 | amino acid activation (GO:0043038) | 3.56812749 |
| 52 | GTP biosynthetic process (GO:0006183) | 3.55792171 |
| 53 | cullin deneddylation (GO:0010388) | 3.53107660 |
| 54 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.51985659 |
| 55 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.51646395 |
| 56 | protein deneddylation (GO:0000338) | 3.50869536 |
| 57 | cytokine production involved in immune response (GO:0002367) | 3.50568317 |
| 58 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.49811399 |
| 59 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.49811399 |
| 60 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.49754960 |
| 61 | protein neddylation (GO:0045116) | 3.45557530 |
| 62 | positive regulation of B cell mediated immunity (GO:0002714) | 3.44994853 |
| 63 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.44994853 |
| 64 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.42974212 |
| 65 | tRNA aminoacylation for protein translation (GO:0006418) | 3.41572841 |
| 66 | positive regulation of ligase activity (GO:0051351) | 3.40934968 |
| 67 | positive regulation of DNA recombination (GO:0045911) | 3.39406024 |
| 68 | respiratory chain complex IV assembly (GO:0008535) | 3.38142936 |
| 69 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.37491450 |
| 70 | nucleobase biosynthetic process (GO:0046112) | 3.35362512 |
| 71 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.34749666 |
| 72 | UTP biosynthetic process (GO:0006228) | 3.33475482 |
| 73 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.27996398 |
| 74 | regulation of immunoglobulin secretion (GO:0051023) | 3.27721084 |
| 75 | positive regulation of isotype switching (GO:0045830) | 3.23441650 |
| 76 | intracellular protein transmembrane import (GO:0044743) | 3.22554135 |
| 77 | positive regulation of cell cycle arrest (GO:0071158) | 3.20980209 |
| 78 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.19113981 |
| 79 | transcription from RNA polymerase I promoter (GO:0006360) | 3.16768782 |
| 80 | maturation of 5.8S rRNA (GO:0000460) | 3.14444032 |
| 81 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.13959376 |
| 82 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.13138674 |
| 83 | positive regulation of immunoglobulin production (GO:0002639) | 3.12855254 |
| 84 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.10069303 |
| 85 | tRNA metabolic process (GO:0006399) | 3.10015883 |
| 86 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.09192222 |
| 87 | regulation of cellular amine metabolic process (GO:0033238) | 3.08237198 |
| 88 | cytochrome complex assembly (GO:0017004) | 3.06846265 |
| 89 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.05363117 |
| 90 | signal peptide processing (GO:0006465) | 3.04946178 |
| 91 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.01776752 |
| 92 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.99755749 |
| 93 | UTP metabolic process (GO:0046051) | 2.96370171 |
| 94 | T-helper cell differentiation (GO:0042093) | 2.95621711 |
| 95 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 2.95621711 |
| 96 | regulation of regulatory T cell differentiation (GO:0045589) | 2.94906338 |
| 97 | regulation of ligase activity (GO:0051340) | 2.94724711 |
| 98 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.92134698 |
| 99 | negative regulation of protein ubiquitination (GO:0031397) | 2.91359684 |
| 100 | mismatch repair (GO:0006298) | 2.90034547 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 6.18855929 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.23827013 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.60109628 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.17060506 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.60616040 |
| 6 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.40322576 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.24878147 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.16602389 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.88717083 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.87212243 |
| 11 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.76458690 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.71504986 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.68607174 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.65750853 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.59760563 |
| 16 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.49767495 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.43729791 |
| 18 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.43707641 |
| 19 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.10109035 |
| 20 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.05232828 |
| 21 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.02122271 |
| 22 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.95371490 |
| 23 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.93655606 |
| 24 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.92212949 |
| 25 | VDR_22108803_ChIP-Seq_LS180_Human | 1.89794934 |
| 26 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.87457244 |
| 27 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.84016214 |
| 28 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.83742572 |
| 29 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.76319750 |
| 30 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.75874191 |
| 31 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.75794529 |
| 32 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.75268113 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.70520001 |
| 34 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.67035940 |
| 35 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.67008485 |
| 36 | EWS_26573619_Chip-Seq_HEK293_Human | 1.65441654 |
| 37 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.65032907 |
| 38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.62559795 |
| 39 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.62188169 |
| 40 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.61460184 |
| 41 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.60419106 |
| 42 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.60037451 |
| 43 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.59895803 |
| 44 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.54168094 |
| 45 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.50268518 |
| 46 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.50235627 |
| 47 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.48791729 |
| 48 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.46942461 |
| 49 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.45282913 |
| 50 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.45035304 |
| 51 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.34793974 |
| 52 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.32728085 |
| 53 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.32211435 |
| 54 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.32054565 |
| 55 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.31104300 |
| 56 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.29258508 |
| 57 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.29210162 |
| 58 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.28773975 |
| 59 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.22100433 |
| 60 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.21056487 |
| 61 | GATA3_26560356_Chip-Seq_TH2_Human | 1.17147455 |
| 62 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.16806983 |
| 63 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15083510 |
| 64 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.11609756 |
| 65 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.09810935 |
| 66 | MYB_26560356_Chip-Seq_TH2_Human | 1.09569312 |
| 67 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.08400881 |
| 68 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.04480028 |
| 69 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.01608171 |
| 70 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.01503554 |
| 71 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.00083292 |
| 72 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.00083292 |
| 73 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.00083292 |
| 74 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.98827039 |
| 75 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.98749783 |
| 76 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.97579343 |
| 77 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.96849723 |
| 78 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.96777892 |
| 79 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.95493934 |
| 80 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92326924 |
| 81 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.92102154 |
| 82 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.92102154 |
| 83 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.90855899 |
| 84 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.90003291 |
| 85 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.88441711 |
| 86 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.88240748 |
| 87 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.87390218 |
| 88 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.87390218 |
| 89 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.87240929 |
| 90 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.85555583 |
| 91 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84226306 |
| 92 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.84195188 |
| 93 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.83409773 |
| 94 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.82349901 |
| 95 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.81348271 |
| 96 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.81027573 |
| 97 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.80027713 |
| 98 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.79722182 |
| 99 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.78271219 |
| 100 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.78190243 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001348_abnormal_lacrimal_gland | 4.85616759 |
| 2 | MP0001873_stomach_inflammation | 4.29630958 |
| 3 | MP0000685_abnormal_immune_system | 4.24743244 |
| 4 | MP0001835_abnormal_antigen_presentation | 3.99343650 |
| 5 | MP0004147_increased_porphyrin_level | 3.88927790 |
| 6 | MP0002138_abnormal_hepatobiliary_system | 3.20423123 |
| 7 | MP0005671_abnormal_response_to | 3.13067300 |
| 8 | MP0002166_altered_tumor_susceptibility | 2.92929927 |
| 9 | MP0001790_abnormal_immune_system | 2.71982704 |
| 10 | MP0005387_immune_system_phenotype | 2.71982704 |
| 11 | MP0003718_maternal_effect | 2.54958621 |
| 12 | MP0002006_tumorigenesis | 2.26782020 |
| 13 | MP0003646_muscle_fatigue | 2.16446688 |
| 14 | MP0003763_abnormal_thymus_physiology | 2.14643658 |
| 15 | MP0009785_altered_susceptibility_to | 2.10937486 |
| 16 | MP0008872_abnormal_physiological_respon | 2.08808034 |
| 17 | MP0002277_abnormal_respiratory_mucosa | 2.08413413 |
| 18 | MP0008058_abnormal_DNA_repair | 1.88708428 |
| 19 | MP0002736_abnormal_nociception_after | 1.85949956 |
| 20 | MP0008875_abnormal_xenobiotic_pharmacok | 1.85793235 |
| 21 | MP0001800_abnormal_humoral_immune | 1.82678593 |
| 22 | MP0009333_abnormal_splenocyte_physiolog | 1.78707977 |
| 23 | MP0002148_abnormal_hypersensitivity_rea | 1.76605061 |
| 24 | MP0006082_CNS_inflammation | 1.74947475 |
| 25 | MP0003786_premature_aging | 1.63520116 |
| 26 | MP0005377_hearing/vestibular/ear_phenot | 1.62988068 |
| 27 | MP0003878_abnormal_ear_physiology | 1.62988068 |
| 28 | MP0003693_abnormal_embryo_hatching | 1.59482013 |
| 29 | MP0004957_abnormal_blastocyst_morpholog | 1.58734729 |
| 30 | MP0005645_abnormal_hypothalamus_physiol | 1.58294754 |
| 31 | MP0003866_abnormal_defecation | 1.56625035 |
| 32 | MP0005084_abnormal_gallbladder_morpholo | 1.55816093 |
| 33 | MP0002405_respiratory_system_inflammati | 1.50729600 |
| 34 | MP0003567_abnormal_fetal_cardiomyocyte | 1.47866593 |
| 35 | MP0002163_abnormal_gland_morphology | 1.47448716 |
| 36 | MP0001501_abnormal_sleep_pattern | 1.44744505 |
| 37 | MP0003011_delayed_dark_adaptation | 1.42218914 |
| 38 | MP0005379_endocrine/exocrine_gland_phen | 1.38275577 |
| 39 | MP0006036_abnormal_mitochondrial_physio | 1.36693275 |
| 40 | MP0003186_abnormal_redox_activity | 1.36654951 |
| 41 | MP0002102_abnormal_ear_morphology | 1.36271313 |
| 42 | MP0002837_dystrophic_cardiac_calcinosis | 1.34498680 |
| 43 | MP0003806_abnormal_nucleotide_metabolis | 1.31187117 |
| 44 | MP0001968_abnormal_touch/_nociception | 1.28374532 |
| 45 | MP0005636_abnormal_mineral_homeostasis | 1.26961791 |
| 46 | MP0008877_abnormal_DNA_methylation | 1.26912709 |
| 47 | MP0005310_abnormal_salivary_gland | 1.24720302 |
| 48 | MP0002723_abnormal_immune_serum | 1.23349114 |
| 49 | MP0005408_hypopigmentation | 1.21409370 |
| 50 | MP0002254_reproductive_system_inflammat | 1.18946760 |
| 51 | MP0000703_abnormal_thymus_morphology | 1.17977897 |
| 52 | MP0005000_abnormal_immune_tolerance | 1.17019973 |
| 53 | MP0005025_abnormal_response_to | 1.11469997 |
| 54 | MP0003045_fibrosis | 1.10859219 |
| 55 | MP0006072_abnormal_retinal_apoptosis | 1.09187998 |
| 56 | MP0004782_abnormal_surfactant_physiolog | 1.06257920 |
| 57 | MP0010094_abnormal_chromosome_stability | 1.06192838 |
| 58 | MP0002420_abnormal_adaptive_immunity | 1.01470054 |
| 59 | MP0002398_abnormal_bone_marrow | 0.99444603 |
| 60 | MP0001819_abnormal_immune_cell | 0.96724190 |
| 61 | MP0001845_abnormal_inflammatory_respons | 0.96065610 |
| 62 | MP0000689_abnormal_spleen_morphology | 0.95834550 |
| 63 | MP0003077_abnormal_cell_cycle | 0.95560935 |
| 64 | MP0002452_abnormal_antigen_presenting | 0.93876953 |
| 65 | MP0000716_abnormal_immune_system | 0.93501740 |
| 66 | MP0004142_abnormal_muscle_tone | 0.90687472 |
| 67 | MP0006035_abnormal_mitochondrial_morpho | 0.89818055 |
| 68 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.89291163 |
| 69 | MP0004084_abnormal_cardiac_muscle | 0.88648093 |
| 70 | MP0006054_spinal_hemorrhage | 0.88287868 |
| 71 | MP0004742_abnormal_vestibular_system | 0.87743971 |
| 72 | MP0008057_abnormal_DNA_replication | 0.87298263 |
| 73 | MP0003436_decreased_susceptibility_to | 0.86893819 |
| 74 | MP0004043_abnormal_pH_regulation | 0.85708938 |
| 75 | MP0005395_other_phenotype | 0.84252881 |
| 76 | MP0001663_abnormal_digestive_system | 0.84033290 |
| 77 | MP0002653_abnormal_ependyma_morphology | 0.83879069 |
| 78 | MP0002938_white_spotting | 0.83811997 |
| 79 | MP0009764_decreased_sensitivity_to | 0.82133692 |
| 80 | MP0010155_abnormal_intestine_physiology | 0.81279703 |
| 81 | MP0002429_abnormal_blood_cell | 0.81200256 |
| 82 | MP0002722_abnormal_immune_system | 0.80363844 |
| 83 | MP0003195_calcinosis | 0.79892357 |
| 84 | MP0004215_abnormal_myocardial_fiber | 0.79726822 |
| 85 | MP0005165_increased_susceptibility_to | 0.79183860 |
| 86 | MP0000490_abnormal_crypts_of | 0.77347584 |
| 87 | MP0005332_abnormal_amino_acid | 0.74848195 |
| 88 | MP0003111_abnormal_nucleus_morphology | 0.74634485 |
| 89 | MP0001919_abnormal_reproductive_system | 0.74568817 |
| 90 | MP0001853_heart_inflammation | 0.73016786 |
| 91 | MP0000627_abnormal_mammary_gland | 0.72450092 |
| 92 | MP0005551_abnormal_eye_electrophysiolog | 0.72265698 |
| 93 | MP0001119_abnormal_female_reproductive | 0.72027477 |
| 94 | MP0003936_abnormal_reproductive_system | 0.70787939 |
| 95 | MP0001529_abnormal_vocalization | 0.70533257 |
| 96 | MP0001485_abnormal_pinna_reflex | 0.69593475 |
| 97 | MP0008469_abnormal_protein_level | 0.68987730 |
| 98 | MP0005167_abnormal_blood-brain_barrier | 0.67504459 |
| 99 | MP0003959_abnormal_lean_body | 0.67259985 |
| 100 | MP0001188_hyperpigmentation | 0.66453860 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased hepatocellular lipid droplets (HP:0006565) | 5.13187384 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.60535654 |
| 3 | Lipid accumulation in hepatocytes (HP:0006561) | 4.48084846 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.35122035 |
| 5 | Increased CSF lactate (HP:0002490) | 4.34094089 |
| 6 | Acute encephalopathy (HP:0006846) | 4.29297977 |
| 7 | Hypoplasia of the pons (HP:0012110) | 4.22290559 |
| 8 | Abnormality of the pons (HP:0007361) | 4.18978210 |
| 9 | Progressive macrocephaly (HP:0004481) | 4.08912646 |
| 10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.86471998 |
| 11 | Conjunctival hamartoma (HP:0100780) | 3.85316276 |
| 12 | Renal Fanconi syndrome (HP:0001994) | 3.64078703 |
| 13 | Hepatocellular necrosis (HP:0001404) | 3.53891984 |
| 14 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.44742189 |
| 15 | Aplastic anemia (HP:0001915) | 3.35125608 |
| 16 | Hepatic necrosis (HP:0002605) | 3.29055849 |
| 17 | IgG deficiency (HP:0004315) | 3.24473938 |
| 18 | Increased serum pyruvate (HP:0003542) | 3.22353219 |
| 19 | Exertional dyspnea (HP:0002875) | 3.16782262 |
| 20 | Increased serum lactate (HP:0002151) | 3.11847660 |
| 21 | Abnormality of glycolysis (HP:0004366) | 3.07253371 |
| 22 | Cerebral edema (HP:0002181) | 3.03365651 |
| 23 | Increased intramyocellular lipid droplets (HP:0012240) | 3.02349636 |
| 24 | Methylmalonic acidemia (HP:0002912) | 2.82721799 |
| 25 | Cerebral hemorrhage (HP:0001342) | 2.82461931 |
| 26 | Respiratory difficulties (HP:0002880) | 2.77056402 |
| 27 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.73594996 |
| 28 | Palpitations (HP:0001962) | 2.73523986 |
| 29 | Increased IgM level (HP:0003496) | 2.66485079 |
| 30 | Cavernous hemangioma (HP:0001048) | 2.65119668 |
| 31 | Optic disc pallor (HP:0000543) | 2.58535192 |
| 32 | Exercise intolerance (HP:0003546) | 2.57060664 |
| 33 | Pheochromocytoma (HP:0002666) | 2.56392461 |
| 34 | Leukodystrophy (HP:0002415) | 2.55936886 |
| 35 | Neuroendocrine neoplasm (HP:0100634) | 2.54323489 |
| 36 | Hyperphosphaturia (HP:0003109) | 2.53373552 |
| 37 | Methylmalonic aciduria (HP:0012120) | 2.52272203 |
| 38 | Stomatitis (HP:0010280) | 2.52161331 |
| 39 | Pancytopenia (HP:0001876) | 2.51925355 |
| 40 | Testicular atrophy (HP:0000029) | 2.50592420 |
| 41 | Lactic acidosis (HP:0003128) | 2.48251021 |
| 42 | Microvesicular hepatic steatosis (HP:0001414) | 2.46339659 |
| 43 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.39203839 |
| 44 | Abnormality of alanine metabolism (HP:0010916) | 2.39203839 |
| 45 | Hyperalaninemia (HP:0003348) | 2.39203839 |
| 46 | Cleft eyelid (HP:0000625) | 2.35227351 |
| 47 | Increased muscle lipid content (HP:0009058) | 2.33254358 |
| 48 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.32272313 |
| 49 | Pancreatic cysts (HP:0001737) | 2.29127844 |
| 50 | Renal cortical cysts (HP:0000803) | 2.24820469 |
| 51 | Meckel diverticulum (HP:0002245) | 2.23557627 |
| 52 | Abnormality of urine glucose concentration (HP:0011016) | 2.20915126 |
| 53 | Glycosuria (HP:0003076) | 2.20915126 |
| 54 | Hamartoma of the eye (HP:0010568) | 2.20779236 |
| 55 | Neoplasm of the adrenal gland (HP:0100631) | 2.20241536 |
| 56 | Lethargy (HP:0001254) | 2.16920815 |
| 57 | Progressive microcephaly (HP:0000253) | 2.16697499 |
| 58 | 3-Methylglutaconic aciduria (HP:0003535) | 2.16647374 |
| 59 | Abnormality of the ileum (HP:0001549) | 2.14814896 |
| 60 | Autoimmune hemolytic anemia (HP:0001890) | 2.13943508 |
| 61 | Respiratory failure (HP:0002878) | 2.12315576 |
| 62 | Abnormality of T cells (HP:0002843) | 2.11875518 |
| 63 | Congenital stationary night blindness (HP:0007642) | 2.09522608 |
| 64 | Angiofibromas (HP:0010615) | 2.07830363 |
| 65 | Adenoma sebaceum (HP:0009720) | 2.07830363 |
| 66 | Cellular immunodeficiency (HP:0005374) | 2.07671509 |
| 67 | Type I transferrin isoform profile (HP:0003642) | 2.04086398 |
| 68 | Recurrent cutaneous fungal infections (HP:0011370) | 2.03609998 |
| 69 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.03609998 |
| 70 | Pigmentary retinal degeneration (HP:0001146) | 2.00827342 |
| 71 | Abnormality of T cell physiology (HP:0011840) | 2.00211529 |
| 72 | Aplasia/Hypoplasia of the ulna (HP:0006495) | 1.94777918 |
| 73 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.94541095 |
| 74 | Dyschromatopsia (HP:0007641) | 1.94428195 |
| 75 | Abnormality of renal resorption (HP:0011038) | 1.93742401 |
| 76 | Oral leukoplakia (HP:0002745) | 1.92742495 |
| 77 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.90722432 |
| 78 | Paralysis (HP:0003470) | 1.89562806 |
| 79 | Forearm undergrowth (HP:0009821) | 1.88245664 |
| 80 | Hypoplasia of the ulna (HP:0003022) | 1.87484462 |
| 81 | Nausea (HP:0002018) | 1.87102430 |
| 82 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.87014557 |
| 83 | Pendular nystagmus (HP:0012043) | 1.86571050 |
| 84 | Abnormal albumin level (HP:0012116) | 1.85277286 |
| 85 | Hypoalbuminemia (HP:0003073) | 1.85277286 |
| 86 | Molar tooth sign on MRI (HP:0002419) | 1.81861971 |
| 87 | Abnormality of midbrain morphology (HP:0002418) | 1.81861971 |
| 88 | Congenital, generalized hypertrichosis (HP:0004540) | 1.81782995 |
| 89 | Abnormality of the renal cortex (HP:0011035) | 1.81400962 |
| 90 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.81118604 |
| 91 | Encephalitis (HP:0002383) | 1.80300211 |
| 92 | T lymphocytopenia (HP:0005403) | 1.80195637 |
| 93 | Disproportionate short-trunk short stature (HP:0003521) | 1.79966004 |
| 94 | Abnormal urine phosphate concentration (HP:0012599) | 1.79792592 |
| 95 | Abnormality of placental membranes (HP:0011409) | 1.79677538 |
| 96 | Amniotic constriction ring (HP:0009775) | 1.79677538 |
| 97 | Metaphyseal dysplasia (HP:0100255) | 1.79564942 |
| 98 | Delayed CNS myelination (HP:0002188) | 1.79228615 |
| 99 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.77870154 |
| 100 | Meningioma (HP:0002858) | 1.73700941 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 4.81016154 |
| 2 | MST4 | 4.67182838 |
| 3 | TSSK6 | 4.50775410 |
| 4 | EIF2AK1 | 3.86408667 |
| 5 | VRK2 | 3.75082039 |
| 6 | EIF2AK3 | 3.61184274 |
| 7 | TRIM28 | 3.40957516 |
| 8 | PBK | 3.38389290 |
| 9 | BUB1 | 3.32773657 |
| 10 | TAF1 | 3.07990565 |
| 11 | SRPK1 | 2.62142761 |
| 12 | NUAK1 | 2.58806954 |
| 13 | NME1 | 2.37334303 |
| 14 | MAP4K1 | 2.12957666 |
| 15 | SIK3 | 2.12195768 |
| 16 | VRK1 | 1.90568487 |
| 17 | ADRBK2 | 1.76190757 |
| 18 | PLK3 | 1.45321295 |
| 19 | PLK4 | 1.44312387 |
| 20 | EIF2AK2 | 1.40960713 |
| 21 | TLK1 | 1.39176401 |
| 22 | AKT3 | 1.29022541 |
| 23 | PASK | 1.28186942 |
| 24 | WNK4 | 1.24094889 |
| 25 | GRK7 | 1.17196458 |
| 26 | LATS1 | 1.15261776 |
| 27 | MAP3K12 | 1.12918783 |
| 28 | GRK1 | 1.08429126 |
| 29 | TNIK | 1.06693966 |
| 30 | NEK1 | 1.00376000 |
| 31 | TAOK3 | 0.99036007 |
| 32 | FRK | 0.98401934 |
| 33 | NME2 | 0.97629654 |
| 34 | PLK2 | 0.93650690 |
| 35 | CDK8 | 0.92815776 |
| 36 | DYRK2 | 0.92696504 |
| 37 | STK3 | 0.90059868 |
| 38 | NEK9 | 0.86702606 |
| 39 | DAPK1 | 0.85414288 |
| 40 | MAPKAPK3 | 0.83712093 |
| 41 | STK39 | 0.82805181 |
| 42 | NLK | 0.78934212 |
| 43 | STK4 | 0.69442256 |
| 44 | BCR | 0.66813326 |
| 45 | ZAK | 0.65770904 |
| 46 | MAP2K6 | 0.65676891 |
| 47 | SCYL2 | 0.65135913 |
| 48 | ALK | 0.63973186 |
| 49 | BCKDK | 0.63267755 |
| 50 | OXSR1 | 0.59769038 |
| 51 | WEE1 | 0.58767470 |
| 52 | IKBKB | 0.55713690 |
| 53 | DAPK2 | 0.55629739 |
| 54 | IRAK4 | 0.53368861 |
| 55 | CLK1 | 0.49985446 |
| 56 | FGFR4 | 0.45313432 |
| 57 | TYK2 | 0.42990572 |
| 58 | SGK2 | 0.41799696 |
| 59 | PLK1 | 0.41750830 |
| 60 | FGFR1 | 0.41742939 |
| 61 | TGFBR1 | 0.41067884 |
| 62 | CSNK2A2 | 0.40410036 |
| 63 | ATR | 0.38627961 |
| 64 | EPHA3 | 0.36229680 |
| 65 | PIK3CG | 0.36030423 |
| 66 | KDR | 0.35382523 |
| 67 | RPS6KA5 | 0.35154006 |
| 68 | TIE1 | 0.33845823 |
| 69 | INSRR | 0.33604162 |
| 70 | CSNK1A1L | 0.33252693 |
| 71 | PHKG1 | 0.32973596 |
| 72 | PHKG2 | 0.32973596 |
| 73 | SYK | 0.32303553 |
| 74 | CSNK2A1 | 0.31377602 |
| 75 | WNK1 | 0.31093157 |
| 76 | MAPKAPK5 | 0.30849414 |
| 77 | TESK2 | 0.30257332 |
| 78 | PAK4 | 0.29652102 |
| 79 | MYLK | 0.28994078 |
| 80 | IKBKE | 0.28717252 |
| 81 | FGFR3 | 0.27772895 |
| 82 | RPS6KA4 | 0.26674787 |
| 83 | ADRBK1 | 0.25542147 |
| 84 | HIPK2 | 0.25373356 |
| 85 | LCK | 0.25278577 |
| 86 | CAMK2A | 0.24575312 |
| 87 | FES | 0.24298031 |
| 88 | BMPR1B | 0.24142954 |
| 89 | MAP4K2 | 0.22533716 |
| 90 | CAMK4 | 0.22475985 |
| 91 | CDC7 | 0.21049846 |
| 92 | DAPK3 | 0.20726663 |
| 93 | SGK223 | 0.20648742 |
| 94 | SGK494 | 0.20648742 |
| 95 | PRKCG | 0.20572020 |
| 96 | KIT | 0.20368094 |
| 97 | IGF1R | 0.19833986 |
| 98 | CSNK1G1 | 0.19583540 |
| 99 | MKNK2 | 0.19215828 |
| 100 | ITK | 0.19148507 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.92781243 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.82788605 |
| 3 | Protein export_Homo sapiens_hsa03060 | 3.55815938 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.04346509 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.99416536 |
| 6 | Asthma_Homo sapiens_hsa05310 | 2.94947206 |
| 7 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.85099858 |
| 8 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.60807388 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.44135043 |
| 10 | Ribosome_Homo sapiens_hsa03010 | 2.22455103 |
| 11 | RNA degradation_Homo sapiens_hsa03018 | 2.08106873 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.00673945 |
| 13 | Mismatch repair_Homo sapiens_hsa03430 | 1.89569647 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 1.78034771 |
| 15 | RNA transport_Homo sapiens_hsa03013 | 1.71580137 |
| 16 | Allograft rejection_Homo sapiens_hsa05330 | 1.69327859 |
| 17 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.68379189 |
| 18 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.65301330 |
| 19 | Homologous recombination_Homo sapiens_hsa03440 | 1.63861814 |
| 20 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.63164892 |
| 21 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.62518875 |
| 22 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.56920257 |
| 23 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.56107565 |
| 24 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.53727768 |
| 25 | Alzheimers disease_Homo sapiens_hsa05010 | 1.50795948 |
| 26 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.49373345 |
| 27 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.45389675 |
| 28 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.42566235 |
| 29 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.39043507 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.36656455 |
| 31 | DNA replication_Homo sapiens_hsa03030 | 1.33593906 |
| 32 | Spliceosome_Homo sapiens_hsa03040 | 1.32789161 |
| 33 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.31098948 |
| 34 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.24082105 |
| 35 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.24004649 |
| 36 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.18737450 |
| 37 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.13094642 |
| 38 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.12149462 |
| 39 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.05265022 |
| 40 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.04440253 |
| 41 | Purine metabolism_Homo sapiens_hsa00230 | 1.03561490 |
| 42 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.02828404 |
| 43 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.95112790 |
| 44 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.92149839 |
| 45 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.89740332 |
| 46 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.87894070 |
| 47 | Measles_Homo sapiens_hsa05162 | 0.85027899 |
| 48 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.83774073 |
| 49 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.80764083 |
| 50 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.79591275 |
| 51 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.75343024 |
| 52 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.70454147 |
| 53 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.68962016 |
| 54 | Sulfur relay system_Homo sapiens_hsa04122 | 0.68036966 |
| 55 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.65545991 |
| 56 | Phototransduction_Homo sapiens_hsa04744 | 0.62200939 |
| 57 | Base excision repair_Homo sapiens_hsa03410 | 0.61590902 |
| 58 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.60935992 |
| 59 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.59138927 |
| 60 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.57618298 |
| 61 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.57164730 |
| 62 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.56715718 |
| 63 | Peroxisome_Homo sapiens_hsa04146 | 0.56596203 |
| 64 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.56201641 |
| 65 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.55932983 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.55012247 |
| 67 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.54620375 |
| 68 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.50139017 |
| 69 | Carbon metabolism_Homo sapiens_hsa01200 | 0.50062383 |
| 70 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.47522192 |
| 71 | Mineral absorption_Homo sapiens_hsa04978 | 0.47057404 |
| 72 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.45341690 |
| 73 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.44831147 |
| 74 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.39962657 |
| 75 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.39459299 |
| 76 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.38957065 |
| 77 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.38346128 |
| 78 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.37167818 |
| 79 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.36915833 |
| 80 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.35732095 |
| 81 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.34924049 |
| 82 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.34275856 |
| 83 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.32951919 |
| 84 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.31251511 |
| 85 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.31233464 |
| 86 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.29436351 |
| 87 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.26243050 |
| 88 | Retinol metabolism_Homo sapiens_hsa00830 | 0.25490938 |
| 89 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.24999018 |
| 90 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.24369970 |
| 91 | Cell cycle_Homo sapiens_hsa04110 | 0.23058020 |
| 92 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.22581609 |
| 93 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.22502909 |
| 94 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.22213264 |
| 95 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.19421024 |
| 96 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.17934374 |
| 97 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.17910415 |
| 98 | HTLV-I infection_Homo sapiens_hsa05166 | 0.17436137 |
| 99 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.16173313 |
| 100 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.15964238 |

