MTHFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.55430567
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.55430567
3modulation by symbiont of host immune response (GO:0052553)5.55430567
4positive regulation by symbiont of host defense response (GO:0052509)5.55430567
5modulation by symbiont of host defense response (GO:0052031)5.55430567
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.55430567
7cellular response to interferon-alpha (GO:0035457)5.06263321
8oxygen transport (GO:0015671)4.91890762
9positive regulation of interferon-alpha production (GO:0032727)4.64187613
10gas transport (GO:0015669)4.61551671
11negative regulation of erythrocyte differentiation (GO:0045647)4.50694654
12regulation of interferon-alpha production (GO:0032647)4.43730334
13regulation of gamma-delta T cell activation (GO:0046643)4.22974978
14macrophage activation involved in immune response (GO:0002281)4.18396352
15regulation of interferon-beta biosynthetic process (GO:0045357)4.15459544
16regulation of gamma-delta T cell differentiation (GO:0045586)4.03855925
17I-kappaB phosphorylation (GO:0007252)3.93798478
18response to interferon-alpha (GO:0035455)3.90697395
19response to type I interferon (GO:0034340)3.75756797
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74000874
21cellular response to type I interferon (GO:0071357)3.73629849
22type I interferon signaling pathway (GO:0060337)3.73629849
23erythrocyte development (GO:0048821)3.69565348
24apoptotic cell clearance (GO:0043277)3.68895550
25response to peptidoglycan (GO:0032494)3.68444334
26regulation of B cell receptor signaling pathway (GO:0050855)3.66816955
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.59482671
28response to host immune response (GO:0052572)3.59482671
29response to muramyl dipeptide (GO:0032495)3.57361383
30positive regulation of interferon-beta production (GO:0032728)3.50832903
31positive regulation of B cell differentiation (GO:0045579)3.49762849
32B cell receptor signaling pathway (GO:0050853)3.41208372
33positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.39473964
34positive thymic T cell selection (GO:0045059)3.38321028
35cell adhesion mediated by integrin (GO:0033627)3.38030656
36positive regulation of natural killer cell differentiation (GO:0032825)3.37776500
37positive regulation of granulocyte differentiation (GO:0030854)3.36865531
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.35697236
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.35697236
40lipopolysaccharide-mediated signaling pathway (GO:0031663)3.34442590
41positive regulation of chemokine biosynthetic process (GO:0045080)3.34118563
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30565770
43response to host (GO:0075136)3.30565770
44response to host defenses (GO:0052200)3.30565770
45low-density lipoprotein particle clearance (GO:0034383)3.29252491
46natural killer cell mediated immunity (GO:0002228)3.27930485
47natural killer cell mediated cytotoxicity (GO:0042267)3.27930485
48macroautophagy (GO:0016236)3.27531540
49neutrophil activation involved in immune response (GO:0002283)3.22062596
50immunoglobulin mediated immune response (GO:0016064)3.17946106
51regulation of dendritic cell antigen processing and presentation (GO:0002604)3.15919253
52positive T cell selection (GO:0043368)3.14038639
53regulation of cholesterol storage (GO:0010885)3.12313296
54germinal center formation (GO:0002467)3.11513326
55cellular extravasation (GO:0045123)3.08700402
56histone H3-K4 trimethylation (GO:0080182)3.06900491
57L-alpha-amino acid transmembrane transport (GO:1902475)3.05917593
58positive regulation of heat generation (GO:0031652)3.05008059
59regulation of type I interferon-mediated signaling pathway (GO:0060338)3.02214066
60NLS-bearing protein import into nucleus (GO:0006607)3.01971527
61positive regulation of p38MAPK cascade (GO:1900745)3.01510245
62antigen processing and presentation of endogenous antigen (GO:0019883)2.98024402
63cellular response to virus (GO:0098586)2.97861108
64myeloid cell development (GO:0061515)2.96511298
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93976601
66regulation of mast cell degranulation (GO:0043304)2.90238234
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89364661
68JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88889330
69negative regulation of viral genome replication (GO:0045071)2.88503875
70regulation of NFAT protein import into nucleus (GO:0051532)2.85968558
71wound healing, spreading of epidermal cells (GO:0035313)2.85457407
72regulation of membrane protein ectodomain proteolysis (GO:0051043)2.83605537
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.82389026
74cellular response to thyroid hormone stimulus (GO:0097067)2.81576328
75regulation of granulocyte differentiation (GO:0030852)2.79382164
76regulation of podosome assembly (GO:0071801)2.78846799
77T cell selection (GO:0045058)2.78686277
78regulation of mast cell activation (GO:0033003)2.78501588
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.78143722
80microglial cell activation (GO:0001774)2.76317927
81regulation of B cell differentiation (GO:0045577)2.75727101
82regulation of T-helper 1 cell differentiation (GO:0045625)2.72651265
83regulation of mononuclear cell migration (GO:0071675)2.71707516
84regulation of mast cell activation involved in immune response (GO:0033006)2.71426261
85embryonic hemopoiesis (GO:0035162)2.69777408
86regulation of interleukin-12 biosynthetic process (GO:0045075)2.68797442
87neuron projection extension involved in neuron projection guidance (GO:1902284)2.68367634
88axon extension involved in axon guidance (GO:0048846)2.68367634
89protoporphyrinogen IX metabolic process (GO:0046501)2.68171978
90NIK/NF-kappaB signaling (GO:0038061)2.67937011
91erythrocyte maturation (GO:0043249)2.67819264
92regulation of interferon-beta production (GO:0032648)2.67647750
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66811085
94iron ion import (GO:0097286)2.66624942
95megakaryocyte development (GO:0035855)2.65506675
96interferon-gamma-mediated signaling pathway (GO:0060333)2.65392816
97positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.62755715
98positive regulation of histone deacetylation (GO:0031065)2.62692020
99pre-miRNA processing (GO:0031054)2.62068315
100negative regulation of T cell mediated immunity (GO:0002710)2.60480011
101detection of other organism (GO:0098543)2.59424069
102positive regulation of Rap GTPase activity (GO:0032854)2.57895588
103endodermal cell differentiation (GO:0035987)2.57598116
104regulation of erythrocyte differentiation (GO:0045646)2.55937088
105detection of bacterium (GO:0016045)2.53688297
106positive regulation of mast cell activation (GO:0033005)2.52608922
107modulation by symbiont of host cellular process (GO:0044068)2.52230000
108positive regulation of antigen processing and presentation (GO:0002579)2.51998214
109granulocyte activation (GO:0036230)2.51186767
110macrophage activation (GO:0042116)2.50679707
111positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.50473434
112mannose metabolic process (GO:0006013)2.49270959
113granulocyte differentiation (GO:0030851)2.48943121
114regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.47900447
115negative regulation of lymphocyte mediated immunity (GO:0002707)2.47606414
116regulation of fever generation (GO:0031620)2.47192937
117thymic T cell selection (GO:0045061)2.46949027
118Peyers patch development (GO:0048541)2.46002698
119mucosal-associated lymphoid tissue development (GO:0048537)2.46002698
120substrate-dependent cell migration (GO:0006929)2.45932122
121potassium ion export (GO:0071435)2.44731294
122regulation of protein polyubiquitination (GO:1902914)2.44141795
123negative regulation of interleukin-12 production (GO:0032695)2.44106735
124regulation of integrin activation (GO:0033623)2.43559727
125positive regulation of gamma-delta T cell activation (GO:0046645)2.43066877
126cellular response to exogenous dsRNA (GO:0071360)2.43062870
127regulation of myeloid leukocyte mediated immunity (GO:0002886)2.42740377
128regulation of interferon-gamma biosynthetic process (GO:0045072)2.42495063
129cellular response to ethanol (GO:0071361)2.41582881
130lymphocyte chemotaxis (GO:0048247)2.40978522
131cellular response to interferon-gamma (GO:0071346)2.39572833
132myeloid cell activation involved in immune response (GO:0002275)2.39466290
133N-acetylneuraminate metabolic process (GO:0006054)2.39049871
134positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.38508435
135positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.36712350
136monocyte chemotaxis (GO:0002548)2.34980489
137positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34166093
138regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33978755
139defense response to protozoan (GO:0042832)2.33880044
140regulation of triglyceride catabolic process (GO:0010896)2.31920431
141positive regulation of mast cell activation involved in immune response (GO:0033008)2.30269225
142positive regulation of mast cell degranulation (GO:0043306)2.30269225
143positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.30225991
144positive regulation of lipid storage (GO:0010884)2.29819442
145B cell mediated immunity (GO:0019724)2.29738895
146response to protozoan (GO:0001562)2.28555502
147definitive hemopoiesis (GO:0060216)2.28052894
148striated muscle atrophy (GO:0014891)2.26835198
149platelet formation (GO:0030220)2.26472359
150regulation of hippo signaling (GO:0035330)2.26359739
151natural killer cell differentiation (GO:0001779)2.26105748
152positive regulation of protein deacetylation (GO:0090312)2.24915405
153detection of external biotic stimulus (GO:0098581)2.24530362
154activated T cell proliferation (GO:0050798)2.24478064
155positive regulation of toll-like receptor signaling pathway (GO:0034123)2.24341397
156regulation of antigen processing and presentation (GO:0002577)2.23473675
157regulation of leukocyte degranulation (GO:0043300)2.23450475
158negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.23013032
159negative regulation of cell killing (GO:0031342)2.23013032
160positive regulation of CREB transcription factor activity (GO:0032793)2.22239899
161negative T cell selection (GO:0043383)2.21907343
162negative regulation of myotube differentiation (GO:0010832)2.21868741
163negative thymic T cell selection (GO:0045060)2.20407363
164regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.20077093
165detection of molecule of bacterial origin (GO:0032490)2.19297389
166nerve growth factor signaling pathway (GO:0038180)2.19088873
167negative regulation of interleukin-6 production (GO:0032715)2.18482213
168protoporphyrinogen IX biosynthetic process (GO:0006782)2.17706545
169NAD biosynthetic process (GO:0009435)2.17699271
170leukocyte degranulation (GO:0043299)2.16944364
171negative regulation of leukocyte mediated immunity (GO:0002704)2.15475347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.27087430
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.47182678
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.18293782
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.16261612
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.02262129
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.07873587
7SCL_19346495_ChIP-Seq_HPC-7_Human3.02881656
8EZH2_22144423_ChIP-Seq_EOC_Human2.81258137
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68602137
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64936238
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.51141911
12* GATA2_19941826_ChIP-Seq_K562_Human2.34499527
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27966536
14* GATA1_19941827_ChIP-Seq_MEL_Mouse2.12680281
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11096736
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.10110829
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02777476
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96292877
19* ELK3_25401928_ChIP-Seq_HUVEC_Human1.92030155
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90296796
21RUNX_20019798_ChIP-Seq_JUKART_Human1.88607600
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88126521
23* KDM2B_26808549_Chip-Seq_DND41_Human1.86002764
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84664274
25CLOCK_20551151_ChIP-Seq_293T_Human1.84569548
26TCF7_22412390_ChIP-Seq_EML_Mouse1.82597565
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81441256
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80122827
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79655696
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.77525632
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.76044585
32* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.74918212
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74132355
34DROSHA_22980978_ChIP-Seq_HELA_Human1.72433830
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70781908
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.67740687
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65521782
38CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64634094
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62797184
40* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62151893
41MYC_22102868_ChIP-Seq_BL_Human1.61624634
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60520540
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60466287
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60248073
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57349442
46* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56396676
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55414669
48LXR_22292898_ChIP-Seq_THP-1_Human1.55161714
49GATA1_22025678_ChIP-Seq_K562_Human1.54029387
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53542224
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52893330
52VDR_21846776_ChIP-Seq_THP-1_Human1.52693560
53* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52050184
54* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51598808
55* MAF_26560356_Chip-Seq_TH1_Human1.47106789
56SPI1_23127762_ChIP-Seq_K562_Human1.44405019
57* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43234666
58BCOR_27268052_Chip-Seq_Bcells_Human1.42820554
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42511278
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.42043972
61* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41733991
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38821323
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37335058
64KDM2B_26808549_Chip-Seq_K562_Human1.36748586
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34520228
66BCL6_27268052_Chip-Seq_Bcells_Human1.33998536
67ATF3_27146783_Chip-Seq_COLON_Human1.33802913
68* MAF_26560356_Chip-Seq_TH2_Human1.31877752
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.30451225
70* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30346142
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28323536
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27757502
73RACK7_27058665_Chip-Seq_MCF-7_Human1.26121269
74VDR_24763502_ChIP-Seq_THP-1_Human1.25436192
75* TFEB_21752829_ChIP-Seq_HELA_Human1.24731955
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.24574071
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.21704189
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21325696
79P68_20966046_ChIP-Seq_HELA_Human1.18243501
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16927102
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16698874
82* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16682698
83* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16318611
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15799985
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14217144
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.13728305
87MYB_26560356_Chip-Seq_TH1_Human1.13194703
88GATA3_27048872_Chip-Seq_THYMUS_Human1.12392571
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12224631
90* UTX_26944678_Chip-Seq_JUKART_Human1.12030510
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.11727035
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11579368
93* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10655562
94KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10608336
95PU_27001747_Chip-Seq_BMDM_Mouse1.10572907
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09150404
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08789997
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.08292184
99* KDM2B_26808549_Chip-Seq_JURKAT_Human1.08206491
100* GATA1_19941826_ChIP-Seq_K562_Human1.08194720
101E2F1_20622854_ChIP-Seq_HELA_Human1.07006120
102* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04698895
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03939073
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.03439039
105* NCOR1_26117541_ChIP-Seq_K562_Human1.03252152
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03188987
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03066134
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03034830
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02835997
110OCT4_19829295_ChIP-Seq_ESCs_Human1.02578993
111* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02361494
112P300_27268052_Chip-Seq_Bcells_Human1.02109660
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.01735568
114BRD4_25478319_ChIP-Seq_HGPS_Human1.01570024
115* SA1_27219007_Chip-Seq_Bcells_Human1.01314586
116CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00847513
117VDR_22108803_ChIP-Seq_LS180_Human0.99561047
118TP53_22127205_ChIP-Seq_IMR90_Human0.99490227
119SPI1_23547873_ChIP-Seq_NB4_Human0.99271406
120MYB_26560356_Chip-Seq_TH2_Human0.97450561
121CTCF_27219007_Chip-Seq_Bcells_Human0.97269569
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96662997
123STAT1_20625510_ChIP-Seq_HELA_Human0.96559750
124VDR_24787735_ChIP-Seq_THP-1_Human0.95785403
125PHF8_20622854_ChIP-Seq_HELA_Human0.95748849
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95483732
127SMC4_20622854_ChIP-Seq_HELA_Human0.94896900
128* SA1_27219007_Chip-Seq_ERYTHROID_Human0.94820958
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94577436
130SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94155416
131* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93443411
132* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93443411
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93273103
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93114108
135CREB1_26743006_Chip-Seq_LNCaP_Human0.91215051
136SMRT_27268052_Chip-Seq_Bcells_Human0.91100312
137* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91009363
138FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89549868
139* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89483049
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89288517
141* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89254586
142RUNX1_27514584_Chip-Seq_MCF-7_Human0.88269929
143GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87270910
144VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86672400
145JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86576797
146NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86343673
147TP63_22573176_ChIP-Seq_HFKS_Human0.86293045
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86153243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.06067867
2MP0003705_abnormal_hypodermis_morpholog3.69012746
3MP0004147_increased_porphyrin_level3.54139249
4MP0003303_peritoneal_inflammation3.40091468
5MP0000569_abnormal_digit_pigmentation3.31081391
6MP0005058_abnormal_lysosome_morphology3.11353993
7MP0004510_myositis2.96687209
8MP0003656_abnormal_erythrocyte_physiolo2.90185045
9MP0005076_abnormal_cell_differentiation2.64831877
10MP0010307_abnormal_tumor_latency2.51326343
11MP0003646_muscle_fatigue2.49814752
12MP0004858_abnormal_nervous_system2.49120676
13MP0005257_abnormal_intraocular_pressure2.39506892
14MP0003436_decreased_susceptibility_to2.37827967
15MP0010352_gastrointestinal_tract_polyps2.27154028
16MP0001835_abnormal_antigen_presentation2.26657197
17MP0006082_CNS_inflammation2.22217947
18MP0003172_abnormal_lysosome_physiology2.21515431
19MP0005451_abnormal_body_composition2.19749689
20MP0004130_abnormal_muscle_cell2.07970293
21MP0005275_abnormal_skin_tensile2.07131773
22MP0009278_abnormal_bone_marrow2.04875127
23MP0001958_emphysema2.01860899
24MP0003566_abnormal_cell_adhesion1.92574120
25MP0004947_skin_inflammation1.87997754
26MP0005387_immune_system_phenotype1.75964294
27MP0001790_abnormal_immune_system1.75964294
28MP0003448_altered_tumor_morphology1.75912370
29MP0001533_abnormal_skeleton_physiology1.74488693
30MP0003300_gastrointestinal_ulcer1.73618859
31MP0002419_abnormal_innate_immunity1.73044996
32MP0003045_fibrosis1.69933704
33MP0000685_abnormal_immune_system1.68419810
34MP0005000_abnormal_immune_tolerance1.65028847
35MP0009785_altered_susceptibility_to1.64365901
36MP0003091_abnormal_cell_migration1.63894707
37MP0004145_abnormal_muscle_electrophysio1.61901215
38MP0002837_dystrophic_cardiac_calcinosis1.60201691
39MP0009840_abnormal_foam_cell1.57077452
40MP0003283_abnormal_digestive_organ1.56214187
41MP0008961_abnormal_basal_metabolism1.51866855
42MP0005025_abnormal_response_to1.50555337
43MP0001873_stomach_inflammation1.50047731
44MP0003879_abnormal_hair_cell1.49693429
45MP0000015_abnormal_ear_pigmentation1.49382213
46MP0005623_abnormal_meninges_morphology1.42730634
47MP0002452_abnormal_antigen_presenting1.42252408
48MP0000604_amyloidosis1.41227221
49MP0005023_abnormal_wound_healing1.36353756
50MP0002998_abnormal_bone_remodeling1.35709407
51MP0002132_abnormal_respiratory_system1.34817189
52MP0000733_abnormal_muscle_development1.34180651
53MP0003828_pulmonary_edema1.33884980
54MP0004036_abnormal_muscle_relaxation1.30801171
55MP0002166_altered_tumor_susceptibility1.30309502
56MP0002723_abnormal_immune_serum1.29110592
57MP0008995_early_reproductive_senescence1.29028440
58MP0002006_tumorigenesis1.27315886
59MP0004084_abnormal_cardiac_muscle1.27154273
60MP0000689_abnormal_spleen_morphology1.25477093
61MP0001800_abnormal_humoral_immune1.25329917
62MP0001986_abnormal_taste_sensitivity1.23258303
63MP0002009_preneoplasia1.23062927
64MP0002148_abnormal_hypersensitivity_rea1.22974701
65MP0008775_abnormal_heart_ventricle1.19976951
66MP0003763_abnormal_thymus_physiology1.18133373
67MP0003075_altered_response_to1.14734130
68MP0003279_aneurysm1.13132711
69MP0005390_skeleton_phenotype1.09880630
70MP0002722_abnormal_immune_system1.08288560
71MP0004272_abnormal_basement_membrane1.05574511
72MP0000343_altered_response_to1.05421068
73MP0002429_abnormal_blood_cell1.05278304
74MP0002138_abnormal_hepatobiliary_system1.04174232
75MP0001845_abnormal_inflammatory_respons1.03119081
76MP0005310_abnormal_salivary_gland1.02439885
77MP0001501_abnormal_sleep_pattern1.02202441
78MP0004381_abnormal_hair_follicle1.01610641
79MP0001819_abnormal_immune_cell1.00663959
80MP0005083_abnormal_biliary_tract0.99742032
81MP0001915_intracranial_hemorrhage0.99274353
82MP0000767_abnormal_smooth_muscle0.99089316
83MP0000858_altered_metastatic_potential0.98263903
84MP0005464_abnormal_platelet_physiology0.97791956
85MP0004808_abnormal_hematopoietic_stem0.97001546
86MP0000750_abnormal_muscle_regeneration0.96139509
87MP0005503_abnormal_tendon_morphology0.95186370
88MP0002405_respiratory_system_inflammati0.94759828
89MP0005174_abnormal_tail_pigmentation0.94707554
90MP0002420_abnormal_adaptive_immunity0.94557999
91MP0008469_abnormal_protein_level0.92461228
92MP0000371_diluted_coat_color0.92015845
93MP0001545_abnormal_hematopoietic_system0.90814439
94MP0005397_hematopoietic_system_phenotyp0.90814439
95MP0005535_abnormal_body_temperature0.90153448
96MP0003724_increased_susceptibility_to0.88800443
97MP0008004_abnormal_stomach_pH0.87585019
98MP0002168_other_aberrant_phenotype0.86966576
99MP0003866_abnormal_defecation0.85608710
100MP0004185_abnormal_adipocyte_glucose0.83150391
101MP0000703_abnormal_thymus_morphology0.81861184
102MP0005670_abnormal_white_adipose0.81609671
103MP0009333_abnormal_splenocyte_physiolog0.81301517
104MP0009764_decreased_sensitivity_to0.81011356
105MP0005167_abnormal_blood-brain_barrier0.80912359
106MP0002332_abnormal_exercise_endurance0.80060824
107MP0002877_abnormal_melanocyte_morpholog0.78569769
108MP0005621_abnormal_cell_physiology0.78309645
109MP0005377_hearing/vestibular/ear_phenot0.78177013
110MP0003878_abnormal_ear_physiology0.78177013
111MP0004484_altered_response_of0.77895693
112MP0000372_irregular_coat_pigmentation0.76605194
113MP0002822_catalepsy0.76481430
114MP0002693_abnormal_pancreas_physiology0.76314733
115MP0001663_abnormal_digestive_system0.75987266
116MP0005636_abnormal_mineral_homeostasis0.75440653
117MP0002928_abnormal_bile_duct0.75188026
118MP0003795_abnormal_bone_structure0.73945306
119MP0001765_abnormal_ion_homeostasis0.73739560
120MP0005666_abnormal_adipose_tissue0.73582463
121MP0003183_abnormal_peptide_metabolism0.72892337
122MP0005334_abnormal_fat_pad0.72824431
123MP0010329_abnormal_lipoprotein_level0.72171987
124MP0000230_abnormal_systemic_arterial0.71583578
125MP0003690_abnormal_glial_cell0.71374204
126MP0005375_adipose_tissue_phenotype0.71201467
127MP0002972_abnormal_cardiac_muscle0.70866691
128MP0005164_abnormal_response_to0.70859890
129MP0001544_abnormal_cardiovascular_syste0.70796179
130MP0005385_cardiovascular_system_phenoty0.70796179
131MP0005197_abnormal_uvea_morphology0.69810823
132MP0004883_abnormal_blood_vessel0.69386728
133MP0009115_abnormal_fat_cell0.68110307
134MP0010155_abnormal_intestine_physiology0.68080932
135MP0003453_abnormal_keratinocyte_physiol0.68020818
136MP0005671_abnormal_response_to0.67965632
137MP0005166_decreased_susceptibility_to0.67512065
138MP0002896_abnormal_bone_mineralization0.67509405
139MP0000716_abnormal_immune_system0.65895327
140MP0002925_abnormal_cardiovascular_devel0.65593948
141MP0003191_abnormal_cellular_cholesterol0.65230803
142MP0002398_abnormal_bone_marrow0.65113702
143MP0008770_decreased_survivor_rate0.63558306
144MP0002295_abnormal_pulmonary_circulatio0.63082371
145MP0002933_joint_inflammation0.61077847
146MP0005508_abnormal_skeleton_morphology0.60472158
147MP0002136_abnormal_kidney_physiology0.60336731
148MP0002060_abnormal_skin_morphology0.59475478
149MP0001614_abnormal_blood_vessel0.58318053
150MP0002086_abnormal_extraembryonic_tissu0.57510495

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)5.57872509
2Reticulocytosis (HP:0001923)4.14469917
3Poikilocytosis (HP:0004447)4.01551405
4Polycythemia (HP:0001901)3.92002755
5Hand muscle atrophy (HP:0009130)3.80474167
6Cerebral aneurysm (HP:0004944)3.71571422
7Abnormal hemoglobin (HP:0011902)3.57336948
8Distal upper limb amyotrophy (HP:0007149)3.47386553
9Upper limb amyotrophy (HP:0009129)3.47386553
10Protrusio acetabuli (HP:0003179)3.34132540
11Autoimmune thrombocytopenia (HP:0001973)3.33522040
12Prolonged bleeding time (HP:0003010)3.33034045
13Gastrointestinal infarctions (HP:0005244)3.30631431
14Premature rupture of membranes (HP:0001788)3.30155386
15Spontaneous hematomas (HP:0007420)3.24388490
16Increased cerebral lipofuscin (HP:0011813)3.23668154
17Recurrent bacterial skin infections (HP:0005406)3.17936017
18Recurrent abscess formation (HP:0002722)3.14749673
19Colitis (HP:0002583)3.04626875
20Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.02246069
21Peritonitis (HP:0002586)3.00298988
22Eczematoid dermatitis (HP:0000976)2.97807437
23Hyperthyroidism (HP:0000836)2.97211701
24Truncus arteriosus (HP:0001660)2.95662851
25Microcytic anemia (HP:0001935)2.90204053
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.86942491
27Chronic obstructive pulmonary disease (HP:0006510)2.83540829
28Obstructive lung disease (HP:0006536)2.83540829
29Ventricular fibrillation (HP:0001663)2.77950261
30Hypertensive crisis (HP:0100735)2.77130811
31Recurrent gram-negative bacterial infections (HP:0005420)2.73562229
32Recurrent cutaneous fungal infections (HP:0011370)2.72754133
33Chronic mucocutaneous candidiasis (HP:0002728)2.72754133
34Tetraparesis (HP:0002273)2.63826526
35Prolonged QT interval (HP:0001657)2.63088588
36Turricephaly (HP:0000262)2.61290132
37Nasal polyposis (HP:0100582)2.60444547
38Stomatitis (HP:0010280)2.58430071
39Syncope (HP:0001279)2.55915072
40Inflammation of the large intestine (HP:0002037)2.54985855
41Asymmetric septal hypertrophy (HP:0001670)2.54752249
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.54643263
43Osteolytic defects of the hand bones (HP:0009699)2.54643263
44Thick nail (HP:0001805)2.54272488
45Hematochezia (HP:0002573)2.53626770
46Abnormality of transition element cation homeostasis (HP:0011030)2.53618131
47Dilatation of the ascending aorta (HP:0005111)2.50117036
48Ankle contracture (HP:0006466)2.45408099
49Hyperventilation (HP:0002883)2.43756333
50Increased serum ferritin (HP:0003281)2.43381693
51Vertebral compression fractures (HP:0002953)2.43292991
52Meningitis (HP:0001287)2.42325647
53Abnormality of iron homeostasis (HP:0011031)2.42075444
54Disinhibition (HP:0000734)2.41581864
55Hemoptysis (HP:0002105)2.41497279
56Abnormality of reticulocytes (HP:0004312)2.40964193
57Albinism (HP:0001022)2.40926039
58Orchitis (HP:0100796)2.40402581
59Gastrointestinal inflammation (HP:0004386)2.39802414
60Gingivitis (HP:0000230)2.39660490
61Bladder diverticulum (HP:0000015)2.39323416
62Epistaxis (HP:0000421)2.37076945
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.34213562
64Systemic lupus erythematosus (HP:0002725)2.33778139
65Acne (HP:0001061)2.33492976
66Abnormality of macrophages (HP:0004311)2.32831657
67Acanthocytosis (HP:0001927)2.32041091
68Hyperacusis (HP:0010780)2.31336329
69Aneurysm (HP:0002617)2.30494086
70Encephalitis (HP:0002383)2.30397211
71Long toe (HP:0010511)2.30203583
72Abnormality of the nasal mucosa (HP:0000433)2.30014473
73Abnormality of the fingertips (HP:0001211)2.26670934
74Frequent falls (HP:0002359)2.26184045
75Seborrheic dermatitis (HP:0001051)2.25952730
76Increased IgE level (HP:0003212)2.25771633
77Keratoconjunctivitis sicca (HP:0001097)2.24355339
78Shallow orbits (HP:0000586)2.22670283
79Hypochromic anemia (HP:0001931)2.21502926
80Vasculitis (HP:0002633)2.21223488
81Aortic aneurysm (HP:0004942)2.20589918
82Keratoconjunctivitis (HP:0001096)2.17774455
83Abnormality of the lower motor neuron (HP:0002366)2.17696054
84Hypochromic microcytic anemia (HP:0004840)2.17471895
85Panhypogammaglobulinemia (HP:0003139)2.13803380
86Pulmonary infiltrates (HP:0002113)2.13086998
87Abnormal EKG (HP:0003115)2.11656470
88Petechiae (HP:0000967)2.11196626
89Mitral valve prolapse (HP:0001634)2.10836988
90Mediastinal lymphadenopathy (HP:0100721)2.10004028
91Porencephaly (HP:0002132)2.08435272
92Abnormality of glycolipid metabolism (HP:0010969)2.08029008
93Abnormality of liposaccharide metabolism (HP:0010968)2.08029008
94Abnormality of glycosphingolipid metabolism (HP:0004343)2.08029008
95Premature loss of primary teeth (HP:0006323)2.07906648
96Elevated erythrocyte sedimentation rate (HP:0003565)2.07583416
97Impaired platelet aggregation (HP:0003540)2.07449724
98Abnormal platelet function (HP:0011869)2.07449724
99Genu recurvatum (HP:0002816)2.07260491
100Agammaglobulinemia (HP:0004432)2.06973146
101Protruding tongue (HP:0010808)2.06839126
102Myositis (HP:0100614)2.05728484
103Vacuolated lymphocytes (HP:0001922)2.05432008
104Rectal prolapse (HP:0002035)2.05109444
105Bowel incontinence (HP:0002607)2.04432183
106Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04425028
107Abnormality of polysaccharide metabolism (HP:0011012)2.04425028
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04425028
109Clumsiness (HP:0002312)2.03703984
110Aortic dissection (HP:0002647)2.01757232
111Periodontitis (HP:0000704)2.00109492
112Upper motor neuron abnormality (HP:0002127)1.99461616
113Loss of speech (HP:0002371)1.99439546
114Ileus (HP:0002595)1.99282092
115Spinal muscular atrophy (HP:0007269)1.97462987
116Hyperlipoproteinemia (HP:0010980)1.96550083
117Cervical subluxation (HP:0003308)1.96356044
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94383518
119Myocardial infarction (HP:0001658)1.94017539
120Ocular albinism (HP:0001107)1.91166428
121Abnormal large intestine physiology (HP:0012700)1.89951392
122Pathologic fracture (HP:0002756)1.88816732
123Ulnar bowing (HP:0003031)1.88715777
124Absent frontal sinuses (HP:0002688)1.88507435
125Osteomyelitis (HP:0002754)1.88437471
126Leukocytosis (HP:0001974)1.86829863
127Decreased circulating renin level (HP:0003351)1.86753736
128Dysmetric saccades (HP:0000641)1.86591216
129Metaphyseal cupping (HP:0003021)1.85683371
130Increased CSF protein (HP:0002922)1.85188363
131Urinary glycosaminoglycan excretion (HP:0003541)1.85067530
132Mucopolysacchariduria (HP:0008155)1.85067530
133Blue sclerae (HP:0000592)1.84851947
134Vertigo (HP:0002321)1.84806890
135Emphysema (HP:0002097)1.83987614
136Retrobulbar optic neuritis (HP:0100654)1.83659478
137Optic neuritis (HP:0100653)1.83659478
138Striae distensae (HP:0001065)1.83145018
139Prostate neoplasm (HP:0100787)1.82612285
140Chest pain (HP:0100749)1.81618080
141Increased connective tissue (HP:0009025)1.81257599
142Sudden death (HP:0001699)1.80958211
143Bowel diverticulosis (HP:0005222)1.80421748
144Radial bowing (HP:0002986)1.80390782
145Plagiocephaly (HP:0001357)1.80296395
146Basal ganglia calcification (HP:0002135)1.79985538
147Soft skin (HP:0000977)1.79591240
148Interstitial pulmonary disease (HP:0006530)1.76178881
149Dysostosis multiplex (HP:0000943)1.75992937
150Recurrent fungal infections (HP:0002841)1.73922026
151Abnormality of the peritoneum (HP:0002585)1.71653519
152Apathy (HP:0000741)1.71260438
153Persistence of primary teeth (HP:0006335)1.70692843
154Axonal loss (HP:0003447)1.70084758
155Recurrent skin infections (HP:0001581)1.69714921
156Arterial thrombosis (HP:0004420)1.69282157
157Fragile skin (HP:0001030)1.68663869
158Spondylolisthesis (HP:0003302)1.68555251
159Urethral obstruction (HP:0000796)1.68013375
160Recurrent viral infections (HP:0004429)1.67027031
161Global brain atrophy (HP:0002283)1.64194203
162Atrophic scars (HP:0001075)1.63279507
163Heterotopia (HP:0002282)1.60695716
164Short nail (HP:0001799)1.60522247
165Macroorchidism (HP:0000053)1.60340390
166Abnormality of the musculature of the hand (HP:0001421)1.60134845
167Nephritis (HP:0000123)1.60082575
168Wrist flexion contracture (HP:0001239)1.59128518
169Vascular tortuosity (HP:0004948)1.57791523
170Arterial tortuosity (HP:0005116)1.56755543
171Pustule (HP:0200039)1.56222833
172Thin bony cortex (HP:0002753)1.56062207
173Diminished motivation (HP:0000745)1.55404362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.52406568
2TRIB33.11995398
3TYK22.97013066
4CDK122.73384139
5CAMK1D2.40038227
6TBK12.38498246
7MAP3K142.34530330
8JAK12.32596335
9TTN2.21899051
10RIPK42.18142046
11DAPK22.12134172
12IKBKE2.06091381
13MAP3K101.94085112
14CAMK1G1.92571300
15TNK21.86987324
16LATS11.85196017
17IRAK31.80645751
18JAK31.79578174
19RIPK11.77321335
20PDGFRA1.76716882
21DDR21.73409024
22PRPF4B1.69613559
23PTK61.68904749
24RPS6KA41.68095246
25FGFR41.67849110
26PKN21.67004748
27MARK21.63108522
28FRK1.62710506
29KIT1.56948556
30BTK1.55952142
31SYK1.53884640
32SIK21.53600572
33MAP3K71.50906890
34ICK1.50000388
35MTOR1.49894563
36BMX1.44917547
37TAOK31.40967136
38AKT31.37170806
39MAPK121.37168834
40NEK21.36761465
41PRKD31.33621708
42TXK1.32898824
43CHUK1.27954021
44TRPM71.27193571
45EEF2K1.25305725
46ACVR1B1.25159102
47IKBKB1.25076883
48NTRK31.23042032
49STK31.20058033
50CDC42BPA1.18221041
51FGFR31.14881502
52SIK11.12779169
53CSK1.12591396
54FES1.10579285
55PRKD21.09378878
56BMPR21.04548478
57LATS21.04003050
58ITK1.03671808
59PIK3CG1.01512470
60KSR20.99877482
61MAP3K110.98710538
62CDK60.96953113
63HIPK20.96104582
64ADRBK20.95494952
65JAK20.95177450
66HCK0.93210903
67TEC0.91633538
68MAP3K10.91268596
69PDK10.90445889
70PDGFRB0.89533992
71PRKAA20.88656044
72LYN0.85652781
73IRAK10.84021365
74PTK20.82030680
75SGK20.82014127
76GRK70.81585414
77GRK60.81512673
78MAP2K60.80893596
79MAP3K130.80582783
80PDPK10.80282407
81OBSCN0.79588728
82TYRO30.77993785
83RPS6KC10.75083700
84RPS6KL10.75083700
85DAPK30.74382835
86MARK30.74217548
87TLK10.73944662
88MAP3K60.73886179
89RPS6KA60.73788712
90BLK0.73478122
91ALK0.73288773
92SGK30.71071929
93MAPK70.70952258
94IRAK40.67039287
95PAK40.65795019
96PAK20.64153573
97TAOK10.64125034
98MAP2K20.64079824
99EPHB10.63353329
100MAP2K10.62741175
101STK380.62639902
102DYRK1B0.61921435
103STK110.61712008
104MAPK150.61641385
105EGFR0.61388003
106IRAK20.60546663
107PRKD10.58954871
108PRKAA10.58748481
109PRKCQ0.58028781
110MATK0.57627057
111PAK60.57252407
112EPHA30.56997825
113CLK10.55570724
114MAPK110.53647080
115MAP3K90.53626473
116MAP2K30.52596826
117SCYL20.51512079
118ZAP700.49612079
119MAP3K20.48907326
120RPS6KA20.48560386
121CDK40.47226981
122PIM10.47118059
123MAP3K50.46923694
124RET0.46343857
125FGR0.45955940
126INSR0.44994432
127TGFBR20.44356654
128BRD40.42624492
129MAP3K30.42345679
130ERBB20.42071779
131WNK10.40772579
132EPHB20.40310077
133CAMKK10.39911269
134MST1R0.37502162
135PRKCH0.37320691
136LCK0.37271401
137DMPK0.36734662
138PINK10.35494927
139MAP4K10.35485186
140PTK2B0.34886951
141STK40.34711416
142SGK10.34684707
143ABL10.33817278
144CSF1R0.33570539
145LRRK20.32641260

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.34031761
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.25271760
3Staphylococcus aureus infection_Homo sapiens_hsa051501.97873704
4Influenza A_Homo sapiens_hsa051641.96720729
5Osteoclast differentiation_Homo sapiens_hsa043801.95101419
6TNF signaling pathway_Homo sapiens_hsa046681.87110299
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.81058035
8Measles_Homo sapiens_hsa051621.74566706
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.73076139
10Autoimmune thyroid disease_Homo sapiens_hsa053201.71773989
11Lysosome_Homo sapiens_hsa041421.70008482
12Tuberculosis_Homo sapiens_hsa051521.64693231
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63233920
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63003629
15Legionellosis_Homo sapiens_hsa051341.62737435
16Toxoplasmosis_Homo sapiens_hsa051451.62620598
17Malaria_Homo sapiens_hsa051441.59841298
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54727479
19Type II diabetes mellitus_Homo sapiens_hsa049301.48058523
20Chronic myeloid leukemia_Homo sapiens_hsa052201.47569751
21Pertussis_Homo sapiens_hsa051331.44789858
22Amoebiasis_Homo sapiens_hsa051461.39821608
23Herpes simplex infection_Homo sapiens_hsa051681.38070258
24Linoleic acid metabolism_Homo sapiens_hsa005911.37187278
25Primary immunodeficiency_Homo sapiens_hsa053401.35416854
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34705965
27Small cell lung cancer_Homo sapiens_hsa052221.34222449
28Hepatitis B_Homo sapiens_hsa051611.34089692
29Apoptosis_Homo sapiens_hsa042101.33470320
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.31690742
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30918019
32Antigen processing and presentation_Homo sapiens_hsa046121.26460658
33Hepatitis C_Homo sapiens_hsa051601.25664864
34Hematopoietic cell lineage_Homo sapiens_hsa046401.24266101
35B cell receptor signaling pathway_Homo sapiens_hsa046621.23283446
36mTOR signaling pathway_Homo sapiens_hsa041501.22117937
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.21020228
38ABC transporters_Homo sapiens_hsa020101.20676385
39Dorso-ventral axis formation_Homo sapiens_hsa043201.18212405
40Insulin resistance_Homo sapiens_hsa049311.16863162
41Graft-versus-host disease_Homo sapiens_hsa053321.14868684
42Viral myocarditis_Homo sapiens_hsa054161.14777391
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.14216157
44Salmonella infection_Homo sapiens_hsa051321.13782968
45Proteoglycans in cancer_Homo sapiens_hsa052051.13229185
46Allograft rejection_Homo sapiens_hsa053301.12809401
47Rheumatoid arthritis_Homo sapiens_hsa053231.11779324
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10955817
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09776482
50Prolactin signaling pathway_Homo sapiens_hsa049171.09498548
51Notch signaling pathway_Homo sapiens_hsa043301.08857637
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08579950
53Phagosome_Homo sapiens_hsa041451.07161974
54Chemokine signaling pathway_Homo sapiens_hsa040621.07105927
55Focal adhesion_Homo sapiens_hsa045101.06040667
56Glycerophospholipid metabolism_Homo sapiens_hsa005641.04406329
57Shigellosis_Homo sapiens_hsa051311.01899107
58ECM-receptor interaction_Homo sapiens_hsa045120.98618672
59MicroRNAs in cancer_Homo sapiens_hsa052060.98421441
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.96289617
61Prion diseases_Homo sapiens_hsa050200.96239863
62HIF-1 signaling pathway_Homo sapiens_hsa040660.96000887
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95044187
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93923139
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92037414
66Pancreatic cancer_Homo sapiens_hsa052120.91843871
67Choline metabolism in cancer_Homo sapiens_hsa052310.90179759
68Acute myeloid leukemia_Homo sapiens_hsa052210.88654494
69Ether lipid metabolism_Homo sapiens_hsa005650.88621166
70Type I diabetes mellitus_Homo sapiens_hsa049400.87537733
71HTLV-I infection_Homo sapiens_hsa051660.87327439
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.86151437
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.86089827
74Adherens junction_Homo sapiens_hsa045200.85965818
75Lysine degradation_Homo sapiens_hsa003100.85878420
76GnRH signaling pathway_Homo sapiens_hsa049120.85265777
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84844292
78Ovarian steroidogenesis_Homo sapiens_hsa049130.82808393
79Glioma_Homo sapiens_hsa052140.81736415
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.81435034
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80567798
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80410190
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79048381
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78944067
85VEGF signaling pathway_Homo sapiens_hsa043700.75964533
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.75432143
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.74157547
88Viral carcinogenesis_Homo sapiens_hsa052030.74119586
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72202068
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71746815
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71334072
92Prostate cancer_Homo sapiens_hsa052150.71195381
93African trypanosomiasis_Homo sapiens_hsa051430.69675412
94Collecting duct acid secretion_Homo sapiens_hsa049660.69096994
95Bladder cancer_Homo sapiens_hsa052190.67286285
96Platelet activation_Homo sapiens_hsa046110.66456388
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65887293
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65460284
99Renal cell carcinoma_Homo sapiens_hsa052110.65199680
100Asthma_Homo sapiens_hsa053100.64657235
101T cell receptor signaling pathway_Homo sapiens_hsa046600.63574396
102Protein digestion and absorption_Homo sapiens_hsa049740.62797950
103Other glycan degradation_Homo sapiens_hsa005110.61521518
104Endometrial cancer_Homo sapiens_hsa052130.61387502
105Estrogen signaling pathway_Homo sapiens_hsa049150.60526822
106Cholinergic synapse_Homo sapiens_hsa047250.60263041
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58871531
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58751620
109Mineral absorption_Homo sapiens_hsa049780.58666993
110Oxytocin signaling pathway_Homo sapiens_hsa049210.58377849
111Insulin signaling pathway_Homo sapiens_hsa049100.58330550
112MAPK signaling pathway_Homo sapiens_hsa040100.58024597
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56960415
114Non-small cell lung cancer_Homo sapiens_hsa052230.56734937
115FoxO signaling pathway_Homo sapiens_hsa040680.56373496
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55351473
117Endocytosis_Homo sapiens_hsa041440.54837204
118Epstein-Barr virus infection_Homo sapiens_hsa051690.53824817
119Inositol phosphate metabolism_Homo sapiens_hsa005620.52960509
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52210860
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51928669
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50289501
123Morphine addiction_Homo sapiens_hsa050320.50035764
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49727524
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48567002
126Olfactory transduction_Homo sapiens_hsa047400.48453865
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.48376047
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47864189
129Calcium signaling pathway_Homo sapiens_hsa040200.47526586
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46787380
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46571049
132Arachidonic acid metabolism_Homo sapiens_hsa005900.44323257
133Serotonergic synapse_Homo sapiens_hsa047260.41223844
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41137758

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