MTHFSD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.93105269
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.76329098
3cardiac ventricle formation (GO:0003211)5.61534179
4antigen processing and presentation of endogenous antigen (GO:0019883)5.31142225
5cardiac chamber formation (GO:0003207)5.25210391
6specification of organ identity (GO:0010092)4.97099523
7positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.95031959
8DNA deamination (GO:0045006)4.91251304
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.82576686
10secondary heart field specification (GO:0003139)4.75973171
11heart field specification (GO:0003128)4.75973171
12facial nerve structural organization (GO:0021612)4.54887636
13spliceosomal tri-snRNP complex assembly (GO:0000244)4.53908727
143-UTR-mediated mRNA stabilization (GO:0070935)4.34520849
15maturation of SSU-rRNA (GO:0030490)4.24071591
16NIK/NF-kappaB signaling (GO:0038061)4.07970272
17cornea development in camera-type eye (GO:0061303)3.89354218
18tRNA methylation (GO:0030488)3.88997681
19protein insertion into membrane (GO:0051205)3.83483295
20negative regulation of granulocyte differentiation (GO:0030853)3.82558700
21motile cilium assembly (GO:0044458)3.82026214
22cranial nerve structural organization (GO:0021604)3.80506763
23response to pheromone (GO:0019236)3.63186682
24retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.55633193
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.47168128
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.47168128
27histone H4 deacetylation (GO:0070933)3.47083211
28positive regulation of histone deacetylation (GO:0031065)3.41242003
29cellular response to virus (GO:0098586)3.40912678
30positive regulation of neuroblast proliferation (GO:0002052)3.35807796
31response to peptidoglycan (GO:0032494)3.35060389
32detection of bacterium (GO:0016045)3.32449999
33negative regulation of erythrocyte differentiation (GO:0045647)3.30336273
34dosage compensation (GO:0007549)3.28550389
35positive regulation by symbiont of host defense response (GO:0052509)3.24353627
36modulation by symbiont of host defense response (GO:0052031)3.24353627
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24353627
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24353627
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.24353627
40modulation by symbiont of host immune response (GO:0052553)3.24353627
41positive regulation of protein deacetylation (GO:0090312)3.23834188
42detection of other organism (GO:0098543)3.22362595
43germinal center formation (GO:0002467)3.20072696
44positive regulation of gamma-delta T cell activation (GO:0046645)3.19535108
45intracellular estrogen receptor signaling pathway (GO:0030520)3.18582903
462-deoxyribonucleotide biosynthetic process (GO:0009265)3.17921728
47deoxyribose phosphate biosynthetic process (GO:0046385)3.17921728
48peptidyl-arginine N-methylation (GO:0035246)3.16179991
49peptidyl-arginine methylation (GO:0018216)3.16179991
50negative regulation of viral release from host cell (GO:1902187)3.15396961
51peptidyl-arginine omega-N-methylation (GO:0035247)3.12048259
52regulation of type I interferon-mediated signaling pathway (GO:0060338)3.11565909
53negative regulation of leukocyte chemotaxis (GO:0002689)3.09253884
54viral genome replication (GO:0019079)3.08797167
55DNA integration (GO:0015074)3.06117013
56interferon-gamma secretion (GO:0072643)3.05307712
57dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.03529877
58regulation of NFAT protein import into nucleus (GO:0051532)3.01395949
59cytochrome complex assembly (GO:0017004)2.98893267
60histone H2A acetylation (GO:0043968)2.98136619
61poly(A)+ mRNA export from nucleus (GO:0016973)2.98033000
62iron-sulfur cluster assembly (GO:0016226)2.94825848
63metallo-sulfur cluster assembly (GO:0031163)2.94825848
64extracellular negative regulation of signal transduction (GO:1900116)2.92584223
65extracellular regulation of signal transduction (GO:1900115)2.92584223
66response to muramyl dipeptide (GO:0032495)2.91113722
67nucleosome disassembly (GO:0006337)2.90858256
68protein-DNA complex disassembly (GO:0032986)2.90858256
69postsynaptic membrane organization (GO:0001941)2.89050755
70polyamine metabolic process (GO:0006595)2.87735363
71GMP metabolic process (GO:0046037)2.85633103
72epithelial cell differentiation involved in prostate gland development (GO:0060742)2.85557619
73ribosomal small subunit assembly (GO:0000028)2.84483272
74histone H3 deacetylation (GO:0070932)2.84021953
75GDP-mannose metabolic process (GO:0019673)2.81780145
76cilium or flagellum-dependent cell motility (GO:0001539)2.81566216
77mesenchymal cell differentiation involved in renal system development (GO:2001012)2.79694322
78mesenchymal cell differentiation involved in kidney development (GO:0072161)2.79694322
79B cell receptor signaling pathway (GO:0050853)2.79403253
80RNA methylation (GO:0001510)2.78940992
81protein retention in ER lumen (GO:0006621)2.78892937
82pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.78479177
83histone H3-K9 demethylation (GO:0033169)2.78442548
84deoxyribonucleotide biosynthetic process (GO:0009263)2.76032916
85respiratory chain complex IV assembly (GO:0008535)2.75744003
86mannose metabolic process (GO:0006013)2.74921056
87cellular response to interferon-beta (GO:0035458)2.73691492
88deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73258604
89histone arginine methylation (GO:0034969)2.70747079
90positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.67971872
91neuronal action potential propagation (GO:0019227)2.67668036
92proteasome assembly (GO:0043248)2.67500345
93sympathetic nervous system development (GO:0048485)2.64110300
94proline biosynthetic process (GO:0006561)2.62527789
95regulation of monocyte differentiation (GO:0045655)2.62197028
96regulation of RNA export from nucleus (GO:0046831)2.62062855
97histone lysine demethylation (GO:0070076)2.61930199
98rRNA modification (GO:0000154)2.61560395
99regulation of histone deacetylation (GO:0031063)2.60628914
100lymphoid progenitor cell differentiation (GO:0002320)2.59554869
101pentose-phosphate shunt (GO:0006098)2.59200850
102positive regulation of protein sumoylation (GO:0033235)2.58749809
103mannosylation (GO:0097502)2.55685041
104regulation of granulocyte differentiation (GO:0030852)2.55451196
105macrophage activation involved in immune response (GO:0002281)2.55034466
106regulation of protein heterodimerization activity (GO:0043497)2.54271184
107cell proliferation in forebrain (GO:0021846)2.53834751
108ribosomal small subunit biogenesis (GO:0042274)2.53467642
109positive regulation of Cdc42 GTPase activity (GO:0043089)2.52678692
110atrioventricular valve morphogenesis (GO:0003181)2.51996312
111regulation of histone H3-K27 methylation (GO:0061085)2.49831709
112trophectodermal cell differentiation (GO:0001829)2.49613258
113rRNA methylation (GO:0031167)2.47647600
114positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.47571467
115negative regulation of myeloid cell apoptotic process (GO:0033033)2.46538961
116regulation of mitochondrial translation (GO:0070129)2.45005791
117tRNA modification (GO:0006400)2.44485915
118histone demethylation (GO:0016577)2.44107797
119peptidyl-lysine dimethylation (GO:0018027)2.44071645
120mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.44041093
121positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.44041093
122platelet formation (GO:0030220)2.42957529
123replicative senescence (GO:0090399)2.42484083
124photoreceptor cell maintenance (GO:0045494)2.42162361
125signal peptide processing (GO:0006465)2.41323693
126negative regulation of cell size (GO:0045792)2.40966282
127SMAD protein complex assembly (GO:0007183)2.40881089
128negative regulation of DNA-templated transcription, elongation (GO:0032785)2.40765594
129regulation of inositol phosphate biosynthetic process (GO:0010919)2.40514020
130detection of external biotic stimulus (GO:0098581)2.40468592
131CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.40176389
132response to interferon-beta (GO:0035456)2.39950005
133negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.39712142
134negative regulation of cell killing (GO:0031342)2.39712142
135organelle disassembly (GO:1903008)2.38959880
136histone H3-K36 demethylation (GO:0070544)2.38926798
137positive regulation of protein kinase C signaling (GO:0090037)2.38902467
138regulation of interferon-beta biosynthetic process (GO:0045357)2.38553351
139modulation by virus of host morphology or physiology (GO:0019048)2.38208170
140endosome to melanosome transport (GO:0035646)2.37991786
141endosome to pigment granule transport (GO:0043485)2.37991786
142regulation of mast cell degranulation (GO:0043304)2.37283559
143negative regulation of interleukin-12 production (GO:0032695)2.35822893
144modulation by virus of host process (GO:0019054)2.35541634
145ganglion development (GO:0061548)2.35327172
146toll-like receptor 3 signaling pathway (GO:0034138)2.35132020
147negative regulation of calcium ion transport into cytosol (GO:0010523)2.34992830
148virion assembly (GO:0019068)2.34652466
149regulation of protein deacetylation (GO:0090311)2.34210884
150intra-S DNA damage checkpoint (GO:0031573)2.34110300
151regulation of leukocyte degranulation (GO:0043300)2.33811438
152purine deoxyribonucleotide catabolic process (GO:0009155)2.33312744
153modulation by symbiont of host cellular process (GO:0044068)2.33274529
154opioid receptor signaling pathway (GO:0038003)2.32870976
155positive regulation of uterine smooth muscle contraction (GO:0070474)2.32870524
156regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32658920
157DNA dealkylation (GO:0035510)2.32415851
158regulation of viral release from host cell (GO:1902186)2.32266376
159response to folic acid (GO:0051593)2.31723899
160antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.31604446
161transcription elongation from RNA polymerase III promoter (GO:0006385)2.31410521
162termination of RNA polymerase III transcription (GO:0006386)2.31410521
163regulation of neuroblast proliferation (GO:1902692)2.31354784
164mRNA stabilization (GO:0048255)2.31267541
165RNA stabilization (GO:0043489)2.31267541
166negative regulation of cell cycle G2/M phase transition (GO:1902750)2.31188320
167tRNA processing (GO:0008033)2.31154248
168regulation of ARF GTPase activity (GO:0032312)2.31055794
169developmental pigmentation (GO:0048066)2.30868838
170positive regulation of granulocyte differentiation (GO:0030854)2.30666074
171regulation of non-canonical Wnt signaling pathway (GO:2000050)2.30418133
172pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.30416072
173mismatch repair (GO:0006298)2.29763372
174regulation of timing of cell differentiation (GO:0048505)2.29747890
175chaperone-mediated protein complex assembly (GO:0051131)2.28778745
176guanosine-containing compound biosynthetic process (GO:1901070)2.28570803
177regulation of nuclear cell cycle DNA replication (GO:0033262)2.28062371
178mitotic chromosome condensation (GO:0007076)2.27963836
179neutrophil activation involved in immune response (GO:0002283)2.27852125
180regulation of necroptotic process (GO:0060544)2.27701722
181regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.27588734
182negative regulation of nitric oxide biosynthetic process (GO:0045019)2.27297592
183positive regulation of transcription factor import into nucleus (GO:0042993)2.27211942
184positive regulation of neurotransmitter secretion (GO:0001956)2.26997084
185centriole assembly (GO:0098534)2.25302043
186mature B cell differentiation (GO:0002335)2.24957862
187T cell lineage commitment (GO:0002360)2.23119760
188neuronal action potential (GO:0019228)2.20531508
189positive regulation of cAMP-mediated signaling (GO:0043950)2.19014012
190mechanoreceptor differentiation (GO:0042490)2.18591001
191inner ear receptor cell differentiation (GO:0060113)2.17918964
192negative regulation of viral genome replication (GO:0045071)2.17501683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.03138691
2VDR_21846776_ChIP-Seq_THP-1_Human3.77070703
3EZH2_22144423_ChIP-Seq_EOC_Human3.24107719
4MYC_22102868_ChIP-Seq_BL_Human2.90066623
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.73739456
6GBX2_23144817_ChIP-Seq_PC3_Human2.71480817
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68143591
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57122993
9IGF1R_20145208_ChIP-Seq_DFB_Human2.51377190
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50463841
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43710422
12LXR_22292898_ChIP-Seq_THP-1_Human2.38159055
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32307132
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.29269830
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10062966
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08312977
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.05133004
18TCF7_22412390_ChIP-Seq_EML_Mouse2.05001481
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.04867093
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.03325359
21KDM2B_26808549_Chip-Seq_DND41_Human2.00806760
22ZNF263_19887448_ChIP-Seq_K562_Human2.00561524
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.99853475
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.97292146
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.97044851
26MAF_26560356_Chip-Seq_TH1_Human1.96713289
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95277550
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91547112
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.90855809
30RACK7_27058665_Chip-Seq_MCF-7_Human1.88562410
31E2F7_22180533_ChIP-Seq_HELA_Human1.88357652
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87728071
33VDR_24763502_ChIP-Seq_THP-1_Human1.86092121
34MAF_26560356_Chip-Seq_TH2_Human1.83120361
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81161891
36DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79549376
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.79468050
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78486540
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77839224
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76959235
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76577115
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73657674
43* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70678013
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.70047909
45* UTX_26944678_Chip-Seq_JUKART_Human1.69699207
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.69456194
47P68_20966046_ChIP-Seq_HELA_Human1.67396584
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66394141
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.65923343
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64544895
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64351258
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.63988152
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63540834
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.63154144
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.62191892
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61111033
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61081156
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59609693
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58266176
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57132334
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56482853
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.56117353
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55526339
64SMC4_20622854_ChIP-Seq_HELA_Human1.54365306
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53232836
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51919671
67XRN2_22483619_ChIP-Seq_HELA_Human1.50592963
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49720238
69TP53_22127205_ChIP-Seq_IMR90_Human1.49209031
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48899665
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.48154754
72* TET1_21451524_ChIP-Seq_MESCs_Mouse1.47509275
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46100161
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.45234596
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44504752
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.43874891
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43519000
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42478882
79ELK1_19687146_ChIP-ChIP_HELA_Human1.38123093
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.38076056
81SPI1_23127762_ChIP-Seq_K562_Human1.36808027
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.36778212
83BCL6_27268052_Chip-Seq_Bcells_Human1.36695463
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36147458
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.35905135
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.34826167
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34003450
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33817262
89P53_22387025_ChIP-Seq_ESCs_Mouse1.33280934
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32842915
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32438933
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32346060
93EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32346060
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.32059809
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29637836
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29569592
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27206552
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26659567
99NCOR1_26117541_ChIP-Seq_K562_Human1.26614322
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26609422
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25346524
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.25210638
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25097022
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25020026
105* GABP_19822575_ChIP-Seq_HepG2_Human1.24195536
106RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23818731
107CREB1_26743006_Chip-Seq_LNCaP_Human1.23732573
108* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23636801
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22834792
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22313859
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21842021
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21719991
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21629200
114ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21599410
115PU1_27457419_Chip-Seq_LIVER_Mouse1.21091058
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20948005
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20457697
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20175881
119SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18902250
120GABP_17652178_ChIP-ChIP_JURKAT_Human1.18430457
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18268826
122CTCF_21964334_Chip-Seq_Bcells_Human1.17806839
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17146974
124PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17096675
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14987948
126FOXP3_21729870_ChIP-Seq_TREG_Human1.13790906
127ZFX_18555785_Chip-Seq_ESCs_Mouse1.13348788
128SPI1_23547873_ChIP-Seq_NB4_Human1.13283970
129BCOR_27268052_Chip-Seq_Bcells_Human1.13146266
130SCL_19346495_ChIP-Seq_HPC-7_Human1.12900579
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11667378
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11430299
133MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11323494
134STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11273863
135RUNX1_27514584_Chip-Seq_MCF-7_Human1.11200620
136E2F1_18555785_Chip-Seq_ESCs_Mouse1.11191395
137ESR2_21235772_ChIP-Seq_MCF-7_Human1.10996325
138PHF8_20622854_ChIP-Seq_HELA_Human1.10866192
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10713512
140REST_21632747_ChIP-Seq_MESCs_Mouse1.10645407
141SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09809650
142PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09361533
143CIITA_25753668_ChIP-Seq_RAJI_Human1.09283602
144NANOG_18555785_Chip-Seq_ESCs_Mouse1.09117156
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09089157
146KDM2B_26808549_Chip-Seq_K562_Human1.08524018
147SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08334926
148SOX2_18555785_Chip-Seq_ESCs_Mouse1.07797862
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07645195
150KDM5A_27292631_Chip-Seq_BREAST_Human1.07065599
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06729560
152FOXP1_21924763_ChIP-Seq_HESCs_Human1.06635323
153GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06481832
154ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06084556
155SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05986516
156NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05575903
157EZH2_27294783_Chip-Seq_NPCs_Mouse1.05288312
158E2F1_20622854_ChIP-Seq_HELA_Human1.04750654
159CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03910238
160CTCF_18555785_Chip-Seq_ESCs_Mouse1.02956468
161P300_18555785_Chip-Seq_ESCs_Mouse1.02852307
162CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02788205
163GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02678930
164YY1_21170310_ChIP-Seq_MESCs_Mouse1.02532897
165DROSHA_22980978_ChIP-Seq_HELA_Human1.02396607
166TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02174479
167OCT4_18555785_Chip-Seq_ESCs_Mouse1.01952329
168REST_18959480_ChIP-ChIP_MESCs_Mouse1.01922452
169RARB_24833708_ChIP-Seq_LIVER_Mouse1.00703935
170PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00617952
171VDR_23849224_ChIP-Seq_CD4+_Human1.00279097
172CTCF_26484167_Chip-Seq_Bcells_Mouse1.00056926
173RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98133327
174RNF2_27304074_Chip-Seq_ESCs_Mouse0.97378979
175KLF4_18555785_Chip-Seq_ESCs_Mouse0.96383441
176SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95844619
177TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95025179
178TP63_17297297_ChIP-ChIP_HaCaT_Human0.94431214
179HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94135912
180SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93930920
181SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93824208
182CMYC_18555785_Chip-Seq_ESCs_Mouse0.93592328
183EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92835082
184BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91473585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.19342137
2MP0001188_hyperpigmentation4.11211005
3MP0005058_abnormal_lysosome_morphology3.59132719
4MP0001986_abnormal_taste_sensitivity3.24542367
5MP0005451_abnormal_body_composition3.10966805
6MP0002653_abnormal_ependyma_morphology2.99203219
7MP0000015_abnormal_ear_pigmentation2.86801726
8MP0009278_abnormal_bone_marrow2.83295138
9MP0005645_abnormal_hypothalamus_physiol2.74027437
10MP0003303_peritoneal_inflammation2.63553724
11MP0003436_decreased_susceptibility_to2.55539304
12MP0003172_abnormal_lysosome_physiology2.54594415
13MP0000566_synostosis2.42554705
14MP0005174_abnormal_tail_pigmentation2.41605340
15MP0002132_abnormal_respiratory_system2.28624740
16MP0005409_darkened_coat_color2.26451832
17MP0008260_abnormal_autophagy2.22609898
18MP0005076_abnormal_cell_differentiation2.20483729
19MP0001849_ear_inflammation2.18080549
20MP0003191_abnormal_cellular_cholesterol2.15847729
21MP0008058_abnormal_DNA_repair2.15362687
22MP0005075_abnormal_melanosome_morpholog2.05856205
23MP0003705_abnormal_hypodermis_morpholog2.04570197
24MP0003656_abnormal_erythrocyte_physiolo1.97832606
25MP0000372_irregular_coat_pigmentation1.97585372
26MP0002638_abnormal_pupillary_reflex1.93658050
27MP0009840_abnormal_foam_cell1.90779194
28MP0010386_abnormal_urinary_bladder1.88220607
29MP0009697_abnormal_copulation1.85700998
30MP0005248_abnormal_Harderian_gland1.81927335
31MP0010234_abnormal_vibrissa_follicle1.80385492
32MP0005025_abnormal_response_to1.78989948
33MP0009379_abnormal_foot_pigmentation1.78872870
34MP0001800_abnormal_humoral_immune1.74842212
35MP0002419_abnormal_innate_immunity1.74627694
36MP0002095_abnormal_skin_pigmentation1.74107591
37MP0003693_abnormal_embryo_hatching1.72691436
38MP0005387_immune_system_phenotype1.71163064
39MP0001790_abnormal_immune_system1.71163064
40MP0003787_abnormal_imprinting1.69813594
41MP0001545_abnormal_hematopoietic_system1.67027022
42MP0005397_hematopoietic_system_phenotyp1.67027022
43MP0004947_skin_inflammation1.65120916
44MP0004233_abnormal_muscle_weight1.65051493
45MP0004859_abnormal_synaptic_plasticity1.63470929
46MP0001968_abnormal_touch/_nociception1.54849705
47MP0005220_abnormal_exocrine_pancreas1.54566289
48MP0002452_abnormal_antigen_presenting1.53548090
49MP0000858_altered_metastatic_potential1.53020192
50MP0002723_abnormal_immune_serum1.51316271
51MP0000569_abnormal_digit_pigmentation1.49665951
52MP0004142_abnormal_muscle_tone1.49308366
53MP0002396_abnormal_hematopoietic_system1.48263403
54MP0000685_abnormal_immune_system1.47787801
55MP0004147_increased_porphyrin_level1.45922630
56MP0002751_abnormal_autonomic_nervous1.43178367
57MP0002420_abnormal_adaptive_immunity1.41208657
58MP0001819_abnormal_immune_cell1.40937077
59MP0002876_abnormal_thyroid_physiology1.39679867
60MP0006035_abnormal_mitochondrial_morpho1.38752574
61MP0010155_abnormal_intestine_physiology1.37886280
62MP0002735_abnormal_chemical_nociception1.36200598
63MP0005000_abnormal_immune_tolerance1.35534319
64MP0000631_abnormal_neuroendocrine_gland1.34725932
65MP0000490_abnormal_crypts_of1.33428307
66MP0009046_muscle_twitch1.32979988
67MP0002405_respiratory_system_inflammati1.32313880
68MP0008007_abnormal_cellular_replicative1.32225014
69MP0005503_abnormal_tendon_morphology1.29301305
70MP0002067_abnormal_sensory_capabilities1.28662378
71MP0005646_abnormal_pituitary_gland1.27880627
72MP0005360_urolithiasis1.25698222
73MP0005501_abnormal_skin_physiology1.23303610
74MP0002557_abnormal_social/conspecific_i1.23148339
75MP0002184_abnormal_innervation1.22706581
76MP0001186_pigmentation_phenotype1.22035718
77MP0000678_abnormal_parathyroid_gland1.21583511
78MP0003111_abnormal_nucleus_morphology1.20741101
79MP0001727_abnormal_embryo_implantation1.20066845
80MP0002177_abnormal_outer_ear1.18630622
81MP0000750_abnormal_muscle_regeneration1.17178912
82MP0003122_maternal_imprinting1.17040787
83MP0002398_abnormal_bone_marrow1.16712070
84MP0000013_abnormal_adipose_tissue1.16011834
85MP0000716_abnormal_immune_system1.15927656
86MP0003221_abnormal_cardiomyocyte_apopto1.15880850
87MP0005083_abnormal_biliary_tract1.15694561
88MP0005310_abnormal_salivary_gland1.15377904
89MP0004885_abnormal_endolymph1.14020971
90MP0003300_gastrointestinal_ulcer1.13867584
91MP0002075_abnormal_coat/hair_pigmentati1.12847694
92MP0002734_abnormal_mechanical_nocicepti1.12171031
93MP0004381_abnormal_hair_follicle1.11976322
94MP0002736_abnormal_nociception_after1.11504099
95MP0000358_abnormal_cell_content/1.11312036
96MP0002722_abnormal_immune_system1.11028515
97MP0003121_genomic_imprinting1.10938165
98MP0003453_abnormal_keratinocyte_physiol1.07808530
99MP0003724_increased_susceptibility_to1.07509431
100MP0002938_white_spotting1.07199263
101MP0006054_spinal_hemorrhage1.06635876
102MP0000681_abnormal_thyroid_gland1.06627213
103MP0003635_abnormal_synaptic_transmissio1.05459933
104MP0001919_abnormal_reproductive_system1.04928474
105MP0001486_abnormal_startle_reflex1.04507927
106MP0002429_abnormal_blood_cell1.02468454
107MP0002160_abnormal_reproductive_system1.01667441
108MP0000689_abnormal_spleen_morphology1.01306209
109MP0000733_abnormal_muscle_development1.01101898
110MP0004858_abnormal_nervous_system1.00662586
111MP0005423_abnormal_somatic_nervous1.00364212
112MP0002163_abnormal_gland_morphology1.00198424
113MP0000003_abnormal_adipose_tissue0.99929324
114MP0008569_lethality_at_weaning0.97691641
115MP0003136_yellow_coat_color0.97551625
116MP0001845_abnormal_inflammatory_respons0.96543171
117MP0000049_abnormal_middle_ear0.95797208
118MP0001663_abnormal_digestive_system0.95476978
119MP0004808_abnormal_hematopoietic_stem0.94887336
120MP0005084_abnormal_gallbladder_morpholo0.94671518
121MP0000026_abnormal_inner_ear0.94343032
122MP0001944_abnormal_pancreas_morphology0.93489152
123MP0003091_abnormal_cell_migration0.93079356
124MP0002693_abnormal_pancreas_physiology0.92566725
125MP0005464_abnormal_platelet_physiology0.91846020
126MP0009745_abnormal_behavioral_response0.91782399
127MP0001835_abnormal_antigen_presentation0.91753231
128MP0000465_gastrointestinal_hemorrhage0.91634900
129MP0002249_abnormal_larynx_morphology0.91452333
130MP0003943_abnormal_hepatobiliary_system0.90288085
131MP0005666_abnormal_adipose_tissue0.89642778
132MP0005379_endocrine/exocrine_gland_phen0.89052199
133MP0001873_stomach_inflammation0.87288971
134MP0009333_abnormal_splenocyte_physiolog0.86990020
135MP0002098_abnormal_vibrissa_morphology0.86518776
136MP0002138_abnormal_hepatobiliary_system0.85110572
137MP0010094_abnormal_chromosome_stability0.84457280
138MP0010030_abnormal_orbit_morphology0.84416549
139MP0004133_heterotaxia0.83588916
140MP0010678_abnormal_skin_adnexa0.82988150
141MP0000371_diluted_coat_color0.82686582
142MP0008469_abnormal_protein_level0.82524857
143MP0005394_taste/olfaction_phenotype0.80824611
144MP0005499_abnormal_olfactory_system0.80824611
145MP0005621_abnormal_cell_physiology0.80525795
146MP0001533_abnormal_skeleton_physiology0.79739235
147MP0000749_muscle_degeneration0.79426519
148MP0008789_abnormal_olfactory_epithelium0.79396533
149MP0004742_abnormal_vestibular_system0.79152766
150MP0002909_abnormal_adrenal_gland0.79104494
151MP0002272_abnormal_nervous_system0.78781267
152MP0000703_abnormal_thymus_morphology0.78712492
153MP0004510_myositis0.78327559
154MP0005171_absent_coat_pigmentation0.77309337
155MP0005384_cellular_phenotype0.77300143
156MP0002572_abnormal_emotion/affect_behav0.76619918
157MP0008961_abnormal_basal_metabolism0.76469349
158MP0001984_abnormal_olfaction0.76209757
159MP0000377_abnormal_hair_follicle0.76128231
160MP0005551_abnormal_eye_electrophysiolog0.75516405
161MP0001348_abnormal_lacrimal_gland0.75422026
162MP0005389_reproductive_system_phenotype0.74999621
163MP0000383_abnormal_hair_follicle0.74912112
164MP0000604_amyloidosis0.74783118
165MP0005375_adipose_tissue_phenotype0.74216112
166MP0005623_abnormal_meninges_morphology0.73818546
167MP0002063_abnormal_learning/memory/cond0.73729357
168MP0000778_abnormal_nervous_system0.73449883
169MP0003786_premature_aging0.73420119
170MP0001346_abnormal_lacrimal_gland0.73008018
171MP0000747_muscle_weakness0.72901263
172MP0002092_abnormal_eye_morphology0.72884418
173MP0005671_abnormal_response_to0.72568928
174MP0005253_abnormal_eye_physiology0.72154283
175MP0005381_digestive/alimentary_phenotyp0.71674456
176MP0002102_abnormal_ear_morphology0.70823460
177MP0002928_abnormal_bile_duct0.70797115
178MP0004185_abnormal_adipocyte_glucose0.70524559
179MP0003763_abnormal_thymus_physiology0.70327113
180MP0006276_abnormal_autonomic_nervous0.70120781
181MP0009785_altered_susceptibility_to0.68573752
182MP0001270_distended_abdomen0.68149427
183MP0008932_abnormal_embryonic_tissue0.67673506
184MP0001963_abnormal_hearing_physiology0.66972401
185MP0002064_seizures0.66834010
186MP0002752_abnormal_somatic_nervous0.66029820

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)5.54004380
2Abnormality of the nasal mucosa (HP:0000433)4.62965023
3Chronic otitis media (HP:0000389)4.62154066
4Type I transferrin isoform profile (HP:0003642)3.86958206
5Febrile seizures (HP:0002373)3.82030847
6Abnormality of the thoracic spine (HP:0100711)3.77793975
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75083141
8Thoracic kyphosis (HP:0002942)3.65086935
9Recurrent abscess formation (HP:0002722)3.52073265
10Severe visual impairment (HP:0001141)3.50775529
11Chronic sinusitis (HP:0011109)3.26412128
12Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.24391658
13Abnormal protein N-linked glycosylation (HP:0012347)3.24391658
14Abnormal protein glycosylation (HP:0012346)3.24391658
15Abnormal glycosylation (HP:0012345)3.24391658
16Poikiloderma (HP:0001029)3.24232791
17Microvesicular hepatic steatosis (HP:0001414)3.22312909
18Metaphyseal cupping (HP:0003021)3.17746995
19Entropion (HP:0000621)3.14412324
20Progressive cerebellar ataxia (HP:0002073)3.12544217
21Chromsome breakage (HP:0040012)3.09555372
22Aplastic anemia (HP:0001915)3.07100628
23Hypothermia (HP:0002045)3.06725536
24Recurrent bacterial skin infections (HP:0005406)3.05765509
25Panhypogammaglobulinemia (HP:0003139)3.00029625
26True hermaphroditism (HP:0010459)2.96857116
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.96016036
28Recurrent bronchitis (HP:0002837)2.92931470
29Protruding tongue (HP:0010808)2.89607900
30Colitis (HP:0002583)2.88812507
31Deep palmar crease (HP:0006191)2.87681074
32Clubbing of toes (HP:0100760)2.86101697
33Pancreatic cysts (HP:0001737)2.84408074
34Flattened epiphyses (HP:0003071)2.78780645
35Capillary hemangiomas (HP:0005306)2.70890547
36Long palpebral fissure (HP:0000637)2.69071804
37Meckel diverticulum (HP:0002245)2.66065422
38Pancreatic fibrosis (HP:0100732)2.62864503
39Increased IgE level (HP:0003212)2.62531568
40Vertebral arch anomaly (HP:0008438)2.57494012
41Eczematoid dermatitis (HP:0000976)2.57237832
42B lymphocytopenia (HP:0010976)2.54773850
43Recurrent viral infections (HP:0004429)2.54101349
44Obstructive lung disease (HP:0006536)2.52562076
45Chronic obstructive pulmonary disease (HP:0006510)2.52562076
46Abnormality of hair growth rate (HP:0011363)2.51674336
47Slow-growing hair (HP:0002217)2.51674336
48Gaze-evoked nystagmus (HP:0000640)2.49654854
49Abnormality of the intervertebral disk (HP:0005108)2.49365735
50Abnormality of the ileum (HP:0001549)2.47725479
51Bulbous nose (HP:0000414)2.46917057
52Abnormality of the preputium (HP:0100587)2.46187962
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.42231998
54Hyperacusis (HP:0010780)2.40230294
55Aplasia/hypoplasia of the uterus (HP:0008684)2.39954871
56Abnormality of the fingertips (HP:0001211)2.32749526
57Thin bony cortex (HP:0002753)2.32666291
58Nephronophthisis (HP:0000090)2.31710675
59Patellar aplasia (HP:0006443)2.31593364
60Abnormal rod and cone electroretinograms (HP:0008323)2.31465049
61Achilles tendon contracture (HP:0001771)2.29396389
62Reduced antithrombin III activity (HP:0001976)2.28249270
63Ragged-red muscle fibers (HP:0003200)2.27971785
64Recurrent sinusitis (HP:0011108)2.27857641
65Recurrent fungal infections (HP:0002841)2.27110374
66Abnormality of the renal medulla (HP:0100957)2.26794829
6711 pairs of ribs (HP:0000878)2.21992583
68Cellulitis (HP:0100658)2.21499068
69Hypoparathyroidism (HP:0000829)2.19541686
70Unilateral renal agenesis (HP:0000122)2.19215510
71Bone marrow hypocellularity (HP:0005528)2.17718035
72Optic nerve hypoplasia (HP:0000609)2.16998049
73Microretrognathia (HP:0000308)2.16943704
74Aplasia/Hypoplasia of the patella (HP:0006498)2.16398876
75Hypoplasia of the thymus (HP:0000778)2.14718227
76Gastrointestinal inflammation (HP:0004386)2.13301846
77Gingivitis (HP:0000230)2.12662531
78Meningitis (HP:0001287)2.12406962
79Acute lymphatic leukemia (HP:0006721)2.11544889
80Reticulocytosis (HP:0001923)2.11275404
81Aplasia/Hypoplasia of the thymus (HP:0010515)2.11087697
82Emphysema (HP:0002097)2.08825079
83Pointed chin (HP:0000307)2.07804296
84Loss of speech (HP:0002371)2.07592885
85Cervical subluxation (HP:0003308)2.07537407
86Congenital hepatic fibrosis (HP:0002612)2.06119158
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.05941155
88Attenuation of retinal blood vessels (HP:0007843)2.05212436
89Severe combined immunodeficiency (HP:0004430)2.02472435
90Renal cortical cysts (HP:0000803)2.02327588
91Recurrent otitis media (HP:0000403)2.01522992
92Nonprogressive disorder (HP:0003680)2.01335962
93Tubulointerstitial nephritis (HP:0001970)1.99497010
94Abnormality of the carotid arteries (HP:0005344)1.99251116
95Recurrent gram-negative bacterial infections (HP:0005420)1.98466923
96Abnormality of the metopic suture (HP:0005556)1.98402193
97Abnormality of macrophages (HP:0004311)1.98112972
98Abnormality of chromosome stability (HP:0003220)1.98013775
99Obstructive sleep apnea (HP:0002870)1.97539391
100High anterior hairline (HP:0009890)1.97331021
101Abnormality of the Achilles tendon (HP:0005109)1.94251353
102Duodenal stenosis (HP:0100867)1.94183189
103Small intestinal stenosis (HP:0012848)1.94183189
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92549095
105Broad distal phalanx of finger (HP:0009836)1.91185700
106Anencephaly (HP:0002323)1.89722388
107Median cleft lip (HP:0000161)1.89362629
108Agitation (HP:0000713)1.88783939
109Male infertility (HP:0003251)1.87696019
110Abnormal lung lobation (HP:0002101)1.87550375
111Hepatocellular necrosis (HP:0001404)1.87340851
112Bronchiectasis (HP:0002110)1.87110744
113Hypoplasia of the fovea (HP:0007750)1.85596578
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.85596578
115Bowel incontinence (HP:0002607)1.85234719
116Ulnar bowing (HP:0003031)1.84805652
117Upper limb amyotrophy (HP:0009129)1.84341938
118Distal upper limb amyotrophy (HP:0007149)1.84341938
119Bronchitis (HP:0012387)1.83620874
120Atelectasis (HP:0100750)1.83532744
121Chronic hepatic failure (HP:0100626)1.82778011
1223-Methylglutaconic aciduria (HP:0003535)1.81773855
123Myelodysplasia (HP:0002863)1.81348198
124Optic nerve coloboma (HP:0000588)1.81280203
125Syringomyelia (HP:0003396)1.81137064
126Spinal cord lesions (HP:0100561)1.81137064
127Progressive external ophthalmoplegia (HP:0000590)1.80475770
128Distal lower limb amyotrophy (HP:0008944)1.79996462
129Viral hepatitis (HP:0006562)1.79812755
130Abnormality of secondary sexual hair (HP:0009888)1.78920341
131Abnormality of the axillary hair (HP:0100134)1.78920341
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.78486555
133Sepsis (HP:0100806)1.77079406
134Flat capital femoral epiphysis (HP:0003370)1.77037217
135Abnormality of the duodenum (HP:0002246)1.77035522
136Triphalangeal thumb (HP:0001199)1.76958322
137Hand muscle atrophy (HP:0009130)1.76000363
138Tented upper lip vermilion (HP:0010804)1.75563531
139Abnormal large intestine physiology (HP:0012700)1.75344341
140Abnormality of B cell number (HP:0010975)1.75313191
141Inflammation of the large intestine (HP:0002037)1.75215059
142Increased cerebral lipofuscin (HP:0011813)1.73651586
143Cupped ribs (HP:0000887)1.73107923
144Recurrent skin infections (HP:0001581)1.72810960
145Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72223729
146Absent epiphyses (HP:0010577)1.72223729
147Increased serum ferritin (HP:0003281)1.71511881
148Abnormality of DNA repair (HP:0003254)1.71505627
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.71350914
150Absent/shortened dynein arms (HP:0200106)1.71350914
151Biconcave vertebral bodies (HP:0004586)1.70751310
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69676104
153Postaxial foot polydactyly (HP:0001830)1.69484025
154Mitral regurgitation (HP:0001653)1.69111712
155Abnormality of the columella (HP:0009929)1.68415658
156Dysostosis multiplex (HP:0000943)1.68023118
157Spinal canal stenosis (HP:0003416)1.67608904
158Prostate neoplasm (HP:0100787)1.67537534
159Dry hair (HP:0011359)1.66921279
160Combined immunodeficiency (HP:0005387)1.66275557
161Preaxial hand polydactyly (HP:0001177)1.65552663
162Thin ribs (HP:0000883)1.65374931
163Broad face (HP:0000283)1.63997059
164Submucous cleft hard palate (HP:0000176)1.63327704
165Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.62897303
166Mediastinal lymphadenopathy (HP:0100721)1.62507042
167Abnormality of reticulocytes (HP:0004312)1.62502699
168Polygenic inheritance (HP:0010982)1.62018267
169Short femoral neck (HP:0100864)1.61911007
170Agammaglobulinemia (HP:0004432)1.61882179
171Distal lower limb muscle weakness (HP:0009053)1.61128577
172Molar tooth sign on MRI (HP:0002419)1.60664921
173Abnormality of midbrain morphology (HP:0002418)1.60664921
174Narrow nasal bridge (HP:0000446)1.60603824
175Prolonged bleeding time (HP:0003010)1.60406236
176Facial diplegia (HP:0001349)1.60129462
177Type 2 muscle fiber atrophy (HP:0003554)1.57489306
178Cystic liver disease (HP:0006706)1.57447641
179Septo-optic dysplasia (HP:0100842)1.57062984
180Narrow forehead (HP:0000341)1.56720033
181Genetic anticipation (HP:0003743)1.55805322
182Recurrent cutaneous fungal infections (HP:0011370)1.55317524
183Chronic mucocutaneous candidiasis (HP:0002728)1.55317524
184Alveolar cell carcinoma (HP:0006519)1.54639870
185Congenital stationary night blindness (HP:0007642)1.54432218
186Premature graying of hair (HP:0002216)1.54035067
187Basal ganglia calcification (HP:0002135)1.53965628
188Focal motor seizures (HP:0011153)1.53489647
189Abnormality of the phalanges of the hallux (HP:0010057)1.52844377
190Oligohydramnios (HP:0001562)1.51900534
191Hyperphosphatemia (HP:0002905)1.51654904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K135.23826438
2TRIB34.03410400
3CASK3.87678188
4AKT33.22195126
5SRPK13.21608134
6ZAK3.04877996
7ERN12.95905519
8SMG12.71271508
9STK162.65998839
10IRAK32.57708682
11ICK2.52805719
12NME22.42372614
13SIK12.34335860
14PINK12.32907939
15CAMKK22.29780645
16MKNK22.22720469
17MAP2K32.20106251
18SGK22.05607136
19PKN22.00925006
20TNIK1.95505735
21VRK11.88601419
22EEF2K1.87289307
23YES11.83762802
24EIF2AK21.82039098
25NTRK31.78287110
26MUSK1.74378740
27MAP2K71.71797004
28TXK1.68556588
29MAP3K71.68311351
30TLK11.64654613
31MARK21.61344893
32BLK1.56878203
33EPHA21.53643518
34MAPK151.53603190
35MAP4K21.51363949
36BMPR1B1.51141915
37MAP2K21.43713679
38MKNK11.41961847
39CDK121.41252168
40TNK21.40816035
41TIE11.39827771
42BRAF1.38658189
43PRPF4B1.35899483
44TYK21.35700446
45IRAK41.34367431
46INSRR1.34271802
47MAP3K121.32447643
48BRD41.32368458
49TAOK11.30499334
50NEK61.29555303
51TESK21.28439034
52ARAF1.28373947
53MAPK131.27811376
54SGK4941.24212161
55SGK2231.24212161
56GRK11.24130518
57CAMK11.21634126
58MAP3K141.20873120
59SGK31.20827216
60TBK11.19235822
61EIF2AK31.18625632
62ERBB31.18227118
63MAP3K101.18179863
64CCNB11.17984381
65DYRK1B1.16938961
66BUB11.10851021
67WNK11.10504841
68TEC1.10106114
69PTK61.09588943
70STK241.09560832
71PLK41.06534826
72EPHB11.06050744
73KSR21.05880551
74IRAK10.98425128
75MOS0.97520624
76CDK190.94950871
77TTN0.94304972
78PIK3CG0.94187371
79CAMKK10.92925197
80MAP3K60.92869407
81MAP3K10.91334706
82RPS6KC10.90444659
83RPS6KL10.90444659
84KIT0.89312629
85MAP3K80.88680751
86UHMK10.88409979
87CDK40.86907471
88MAP2K40.85507950
89MAP3K30.85085987
90MAP2K60.81725861
91AURKA0.81136819
92CHUK0.79744836
93GRK60.79017870
94RPS6KB20.78699347
95HCK0.77349231
96ADRBK20.76954821
97ACVR1B0.76590256
98TESK10.76410646
99ATR0.74909368
100RPS6KA20.74636624
101HIPK20.74116519
102MTOR0.73974679
103MAP3K90.73714291
104DAPK20.73500133
105DYRK1A0.72512429
106CSK0.71877810
107RPS6KA60.70819816
108IRAK20.70105399
109BCKDK0.68121020
110PDPK10.67873551
111STK380.67691199
112CDK90.65290066
113FLT30.65204528
114DYRK30.64260972
115CDK80.63723354
116PRKCG0.62501913
117CSF1R0.61821380
118SIK20.61305021
119SIK30.61225787
120CAMK40.60984506
121MAP3K110.60863679
122CLK10.60619082
123IKBKB0.59165473
124LRRK20.56164751
125TAOK30.55815032
126FES0.54546311
127CDC42BPA0.54455756
128SYK0.52848026
129RPS6KA40.51475137
130PRKD30.49802309
131MAP4K10.49349526
132LMTK20.49259865
133NUAK10.47992224
134MST1R0.47931298
135PAK40.47075282
136MAPKAPK30.45522958
137MAP3K50.44407568
138MAPK110.44400426
139TGFBR10.42773927
140STK100.42642422
141PDGFRA0.42052578
142NME10.41902742
143BMPR20.41761425
144PRKG20.41193332
145SGK10.40576907
146JAK30.39289744
147PRKD20.39015278
148DAPK10.38657663
149PRKCE0.38475995
150LYN0.36895311
151PIM20.36594971
152ZAP700.36262447
153CDK70.36058813
154RPS6KB10.35800061
155TAOK20.35224981
156ADRBK10.34935229
157IKBKE0.34781459
158BTK0.32047099
159RIPK40.31760824
160CHEK20.30769221
161NLK0.28833558
162CDC70.27024353
163CSNK2A10.25573866
164MAPK100.25223838

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.17373181
2Fanconi anemia pathway_Homo sapiens_hsa034603.00584827
3B cell receptor signaling pathway_Homo sapiens_hsa046622.36609369
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.24238035
5DNA replication_Homo sapiens_hsa030302.20390852
6Chronic myeloid leukemia_Homo sapiens_hsa052202.18493797
7N-Glycan biosynthesis_Homo sapiens_hsa005102.02832733
8Base excision repair_Homo sapiens_hsa034101.99506874
9Mismatch repair_Homo sapiens_hsa034301.99261813
10Protein export_Homo sapiens_hsa030601.97920207
11Pancreatic cancer_Homo sapiens_hsa052121.87599765
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85819795
13Nicotine addiction_Homo sapiens_hsa050331.83701089
14Osteoclast differentiation_Homo sapiens_hsa043801.83252584
15Non-small cell lung cancer_Homo sapiens_hsa052231.80162490
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.77495359
17Pyrimidine metabolism_Homo sapiens_hsa002401.75378673
18Bladder cancer_Homo sapiens_hsa052191.74102521
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70706816
20Leishmaniasis_Homo sapiens_hsa051401.69451380
21VEGF signaling pathway_Homo sapiens_hsa043701.69372283
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65669721
23Hepatitis C_Homo sapiens_hsa051601.63762699
24RNA polymerase_Homo sapiens_hsa030201.60225431
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.55723099
26Thyroid cancer_Homo sapiens_hsa052161.54606846
27Proteasome_Homo sapiens_hsa030501.52927448
28Ribosome_Homo sapiens_hsa030101.51716090
29Taste transduction_Homo sapiens_hsa047421.51229360
30Endometrial cancer_Homo sapiens_hsa052131.49277986
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.48615552
32Hepatitis B_Homo sapiens_hsa051611.48363506
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41235529
34Apoptosis_Homo sapiens_hsa042101.36455895
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.31079690
36Spliceosome_Homo sapiens_hsa030401.30279491
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25539255
38Synaptic vesicle cycle_Homo sapiens_hsa047211.25087004
39Tuberculosis_Homo sapiens_hsa051521.24937370
40Viral myocarditis_Homo sapiens_hsa054161.23074908
41Purine metabolism_Homo sapiens_hsa002301.23065700
42Renal cell carcinoma_Homo sapiens_hsa052111.21506658
43Olfactory transduction_Homo sapiens_hsa047401.20822150
44Lysosome_Homo sapiens_hsa041421.19924829
45Regulation of autophagy_Homo sapiens_hsa041401.17832415
46Toxoplasmosis_Homo sapiens_hsa051451.16622041
47Nucleotide excision repair_Homo sapiens_hsa034201.15967128
48Colorectal cancer_Homo sapiens_hsa052101.14297166
49Morphine addiction_Homo sapiens_hsa050321.14208150
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12921820
51Phototransduction_Homo sapiens_hsa047441.10168896
52TNF signaling pathway_Homo sapiens_hsa046681.09861794
53Insulin secretion_Homo sapiens_hsa049111.08599598
54Shigellosis_Homo sapiens_hsa051311.07347331
55Primary immunodeficiency_Homo sapiens_hsa053401.07244045
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.06545702
57Sphingolipid metabolism_Homo sapiens_hsa006001.06184475
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06109101
59Prolactin signaling pathway_Homo sapiens_hsa049171.04887365
60Measles_Homo sapiens_hsa051621.03105744
61Choline metabolism in cancer_Homo sapiens_hsa052311.02670050
62Viral carcinogenesis_Homo sapiens_hsa052031.00531731
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.99876638
64Non-homologous end-joining_Homo sapiens_hsa034500.99752485
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98393132
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98171387
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96592677
68Staphylococcus aureus infection_Homo sapiens_hsa051500.96397121
69mTOR signaling pathway_Homo sapiens_hsa041500.95672144
70Herpes simplex infection_Homo sapiens_hsa051680.94775246
71Calcium signaling pathway_Homo sapiens_hsa040200.93825809
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93576433
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93476081
74FoxO signaling pathway_Homo sapiens_hsa040680.93464145
75Alcoholism_Homo sapiens_hsa050340.92999893
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91875740
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90621734
78Folate biosynthesis_Homo sapiens_hsa007900.89021502
79Other glycan degradation_Homo sapiens_hsa005110.88934072
80One carbon pool by folate_Homo sapiens_hsa006700.88392304
81Hematopoietic cell lineage_Homo sapiens_hsa046400.87588049
82Cell cycle_Homo sapiens_hsa041100.86116661
83Inositol phosphate metabolism_Homo sapiens_hsa005620.85920069
84Insulin signaling pathway_Homo sapiens_hsa049100.85538298
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85327441
86Type I diabetes mellitus_Homo sapiens_hsa049400.85021458
87Systemic lupus erythematosus_Homo sapiens_hsa053220.85011380
88Allograft rejection_Homo sapiens_hsa053300.84370234
89Basal transcription factors_Homo sapiens_hsa030220.84039514
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83774678
91Salmonella infection_Homo sapiens_hsa051320.83436425
92Circadian entrainment_Homo sapiens_hsa047130.82406225
93Epstein-Barr virus infection_Homo sapiens_hsa051690.81991376
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.81680084
95Sulfur relay system_Homo sapiens_hsa041220.81278072
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81076854
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80728940
98Pentose phosphate pathway_Homo sapiens_hsa000300.80300217
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.78740260
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78723259
101Lysine degradation_Homo sapiens_hsa003100.78692252
102Antigen processing and presentation_Homo sapiens_hsa046120.77811433
103Prostate cancer_Homo sapiens_hsa052150.77554606
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76669419
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76341738
106T cell receptor signaling pathway_Homo sapiens_hsa046600.76072334
107Influenza A_Homo sapiens_hsa051640.75762488
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75351852
109Endocytosis_Homo sapiens_hsa041440.74551470
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.74251553
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.73151070
112Biosynthesis of amino acids_Homo sapiens_hsa012300.72841321
113Pancreatic secretion_Homo sapiens_hsa049720.72198361
114p53 signaling pathway_Homo sapiens_hsa041150.71958143
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71447350
116Basal cell carcinoma_Homo sapiens_hsa052170.70616908
117Small cell lung cancer_Homo sapiens_hsa052220.69831310
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.68357391
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.68228334
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67777090
121Galactose metabolism_Homo sapiens_hsa000520.65781368
122RNA degradation_Homo sapiens_hsa030180.65092877
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64995816
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64898590
125Circadian rhythm_Homo sapiens_hsa047100.64745963
126AMPK signaling pathway_Homo sapiens_hsa041520.63707375
127Rheumatoid arthritis_Homo sapiens_hsa053230.63374840
128Glutamatergic synapse_Homo sapiens_hsa047240.62911218
129GnRH signaling pathway_Homo sapiens_hsa049120.62445980
130Insulin resistance_Homo sapiens_hsa049310.62174503
131Phagosome_Homo sapiens_hsa041450.59832673
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59463357
133Malaria_Homo sapiens_hsa051440.58676403
134RNA transport_Homo sapiens_hsa030130.56957733
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56936289
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56569517
137Vibrio cholerae infection_Homo sapiens_hsa051100.55763078
138Cholinergic synapse_Homo sapiens_hsa047250.55131547
139Arachidonic acid metabolism_Homo sapiens_hsa005900.54991198
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53687333
141Wnt signaling pathway_Homo sapiens_hsa043100.53257982
142Serotonergic synapse_Homo sapiens_hsa047260.52536614
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52517524
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.52223792
145Glioma_Homo sapiens_hsa052140.51822189
146Hedgehog signaling pathway_Homo sapiens_hsa043400.51323184
147Chemokine signaling pathway_Homo sapiens_hsa040620.51283401
148Phenylalanine metabolism_Homo sapiens_hsa003600.49932032
149Legionellosis_Homo sapiens_hsa051340.47518699
150HTLV-I infection_Homo sapiens_hsa051660.47160392
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45528379
152Asthma_Homo sapiens_hsa053100.45114748
153MicroRNAs in cancer_Homo sapiens_hsa052060.44856788
154Graft-versus-host disease_Homo sapiens_hsa053320.44440018
155Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44093758
156Fructose and mannose metabolism_Homo sapiens_hsa000510.42710968
157Axon guidance_Homo sapiens_hsa043600.42589530
158Protein digestion and absorption_Homo sapiens_hsa049740.41241795
159Notch signaling pathway_Homo sapiens_hsa043300.40999573
160Acute myeloid leukemia_Homo sapiens_hsa052210.40342503
161Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39570538
162Jak-STAT signaling pathway_Homo sapiens_hsa046300.38293172
163mRNA surveillance pathway_Homo sapiens_hsa030150.36419257
164Neurotrophin signaling pathway_Homo sapiens_hsa047220.35894186
165Huntingtons disease_Homo sapiens_hsa050160.34323885
166ErbB signaling pathway_Homo sapiens_hsa040120.34048694
167Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33864546

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