MTIF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.36631719
2maturation of SSU-rRNA (GO:0030490)4.87084522
3nuclear pore organization (GO:0006999)4.72236003
4formation of translation preinitiation complex (GO:0001731)4.49763851
5ribosome assembly (GO:0042255)4.44341537
6ribosomal large subunit biogenesis (GO:0042273)4.39150746
7DNA unwinding involved in DNA replication (GO:0006268)4.33169728
8ribosomal small subunit biogenesis (GO:0042274)4.16808764
9DNA strand elongation involved in DNA replication (GO:0006271)4.16255214
10ribonucleoprotein complex biogenesis (GO:0022613)4.08594895
11DNA replication checkpoint (GO:0000076)4.08500701
12ribosome biogenesis (GO:0042254)4.06171496
13regulation of translational fidelity (GO:0006450)4.05844626
14protein complex biogenesis (GO:0070271)4.03646556
15DNA strand elongation (GO:0022616)4.02643350
16pore complex assembly (GO:0046931)3.95855103
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.91249553
18NADH dehydrogenase complex assembly (GO:0010257)3.91249553
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91249553
20establishment of integrated proviral latency (GO:0075713)3.79740307
21mitotic sister chromatid segregation (GO:0000070)3.77154361
22oxidative phosphorylation (GO:0006119)3.75841693
23mitotic metaphase plate congression (GO:0007080)3.74746350
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74497997
25mitotic chromosome condensation (GO:0007076)3.74371453
26protein localization to kinetochore (GO:0034501)3.73568642
27sister chromatid segregation (GO:0000819)3.71736015
28NAD biosynthetic process (GO:0009435)3.67812101
29mitochondrial respiratory chain complex assembly (GO:0033108)3.65769953
30tRNA aminoacylation for protein translation (GO:0006418)3.65768932
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.65403244
32translational termination (GO:0006415)3.63588340
33tRNA aminoacylation (GO:0043039)3.62948140
34amino acid activation (GO:0043038)3.62948140
35regulation of centriole replication (GO:0046599)3.62818167
36viral transcription (GO:0019083)3.61680677
37protein localization to chromosome, centromeric region (GO:0071459)3.60627714
38folic acid-containing compound biosynthetic process (GO:0009396)3.59299241
39DNA topological change (GO:0006265)3.58494695
40non-recombinational repair (GO:0000726)3.50055477
41double-strand break repair via nonhomologous end joining (GO:0006303)3.50055477
42mitotic nuclear envelope disassembly (GO:0007077)3.49856459
43translational initiation (GO:0006413)3.47419832
44IMP biosynthetic process (GO:0006188)3.43684967
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38802729
46cytochrome complex assembly (GO:0017004)3.36616887
47respiratory electron transport chain (GO:0022904)3.35660834
48metaphase plate congression (GO:0051310)3.34419968
49cotranslational protein targeting to membrane (GO:0006613)3.33947985
50polyketide metabolic process (GO:0030638)3.32796509
51doxorubicin metabolic process (GO:0044598)3.32796509
52daunorubicin metabolic process (GO:0044597)3.32796509
53mitotic sister chromatid cohesion (GO:0007064)3.32559389
54DNA replication initiation (GO:0006270)3.32066421
55regulation of nuclear cell cycle DNA replication (GO:0033262)3.30158075
56protein targeting to ER (GO:0045047)3.29327282
57regulation of centrosome cycle (GO:0046605)3.29256346
58rRNA processing (GO:0006364)3.29105055
59cellular component biogenesis (GO:0044085)3.27903392
60respiratory chain complex IV assembly (GO:0008535)3.25835148
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25309988
62branched-chain amino acid catabolic process (GO:0009083)3.25017993
63IMP metabolic process (GO:0046040)3.24907993
64electron transport chain (GO:0022900)3.23409847
65superoxide anion generation (GO:0042554)3.23209590
66kinetochore organization (GO:0051383)3.22861258
67pteridine-containing compound biosynthetic process (GO:0042559)3.22113969
68nucleotide transmembrane transport (GO:1901679)3.21962615
69tryptophan catabolic process (GO:0006569)3.20611628
70indole-containing compound catabolic process (GO:0042436)3.20611628
71indolalkylamine catabolic process (GO:0046218)3.20611628
72translational elongation (GO:0006414)3.20491724
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.20462593
74rRNA metabolic process (GO:0016072)3.19273142
75nucleobase-containing small molecule interconversion (GO:0015949)3.16324633
76nuclear envelope disassembly (GO:0051081)3.14774476
77membrane disassembly (GO:0030397)3.14774476
78CENP-A containing nucleosome assembly (GO:0034080)3.14208380
79translation (GO:0006412)3.13524290
80protein localization to endoplasmic reticulum (GO:0070972)3.11211547
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11187408
82histone exchange (GO:0043486)3.08993152
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.04827143
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04827143
85kinetochore assembly (GO:0051382)3.02526280
86chromatin remodeling at centromere (GO:0031055)3.01905554
87resolution of meiotic recombination intermediates (GO:0000712)3.00118505
88regulation of translational elongation (GO:0006448)2.98011971
89tryptophan metabolic process (GO:0006568)2.96700512
90viral life cycle (GO:0019058)2.96188951
91telomere maintenance via recombination (GO:0000722)2.95559956
92ATP synthesis coupled proton transport (GO:0015986)2.95324352
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95324352
94regulation of mitotic spindle organization (GO:0060236)2.94711435
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91353228
96chromosome segregation (GO:0007059)2.90646234
97DNA ligation (GO:0006266)2.88969246
98regulation of mitochondrial translation (GO:0070129)2.87838609
99regulation of centrosome duplication (GO:0010824)2.86561095
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86281585
101aerobic respiration (GO:0009060)2.85888463
102centriole assembly (GO:0098534)2.85624416
103establishment of protein localization to mitochondrial membrane (GO:0090151)2.84936693
104RNA-dependent DNA replication (GO:0006278)2.84654844
105anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84261591
106aromatic amino acid family catabolic process (GO:0009074)2.83139114
107establishment of chromosome localization (GO:0051303)2.83051051
108regulation of chromosome segregation (GO:0051983)2.83017909
109maturation of 5.8S rRNA (GO:0000460)2.82638762
110spindle checkpoint (GO:0031577)2.82345779
111cellular protein complex disassembly (GO:0043624)2.82150197
112regulation of spindle organization (GO:0090224)2.81911495
113regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80792556
114histone H3-K4 trimethylation (GO:0080182)2.80645855
115pyridine nucleotide biosynthetic process (GO:0019363)2.79868727
116nicotinamide nucleotide biosynthetic process (GO:0019359)2.79868727
117adenosine metabolic process (GO:0046085)2.79705211
118mitotic spindle checkpoint (GO:0071174)2.78390651
119viral mRNA export from host cell nucleus (GO:0046784)2.78309704
120positive regulation of histone H3-K4 methylation (GO:0051571)2.75443265
121meiotic chromosome segregation (GO:0045132)2.74647856
122heart contraction (GO:0060047)2.74629946
123heart process (GO:0003015)2.74629946
124cellular biogenic amine catabolic process (GO:0042402)2.72193975
125amine catabolic process (GO:0009310)2.72193975
126mitotic recombination (GO:0006312)2.70318485
127cellular response to interferon-beta (GO:0035458)2.68425774
128cellular respiration (GO:0045333)2.65903315
129branched-chain amino acid metabolic process (GO:0009081)2.64669322
130dopamine transport (GO:0015872)2.61820584
131inner mitochondrial membrane organization (GO:0007007)2.60115752
132DNA replication-independent nucleosome organization (GO:0034724)2.53548966
133DNA replication-independent nucleosome assembly (GO:0006336)2.53548966
134short-chain fatty acid metabolic process (GO:0046459)2.52534973
135regulation of bile acid biosynthetic process (GO:0070857)2.52411842
136blood coagulation, intrinsic pathway (GO:0007597)2.52246135
137purine nucleobase biosynthetic process (GO:0009113)2.52217159
138ribosomal small subunit assembly (GO:0000028)2.50833014
139platelet dense granule organization (GO:0060155)2.50500826
140tRNA processing (GO:0008033)2.49862427
141negative regulation of mast cell activation (GO:0033004)2.49801798
142indolalkylamine metabolic process (GO:0006586)2.49372511
143protein-cofactor linkage (GO:0018065)2.47864426
144proteasome assembly (GO:0043248)2.46570123
145regulation of RIG-I signaling pathway (GO:0039535)2.45885762
146regulation of DNA endoreduplication (GO:0032875)2.45073106
147negative regulation of DNA-dependent DNA replication (GO:2000104)2.44964612
148L-phenylalanine catabolic process (GO:0006559)2.41868332
149erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.41868332
150centriole replication (GO:0007099)2.41475664
151rRNA modification (GO:0000154)2.40218712
152transcription elongation from RNA polymerase I promoter (GO:0006362)2.40125586
153telomere maintenance via semi-conservative replication (GO:0032201)2.39830825
154tRNA methylation (GO:0030488)2.39605491
155deoxyribose phosphate biosynthetic process (GO:0046385)2.38860031
1562-deoxyribonucleotide biosynthetic process (GO:0009265)2.38860031
157protein neddylation (GO:0045116)2.38279418
158aldehyde catabolic process (GO:0046185)2.37715440
159mitochondrial RNA metabolic process (GO:0000959)2.37091446
160ubiquinone biosynthetic process (GO:0006744)2.36759672
161quinone biosynthetic process (GO:1901663)2.36759672
162tRNA modification (GO:0006400)2.35918728
163alkaloid metabolic process (GO:0009820)2.34893233
164ubiquinone metabolic process (GO:0006743)2.34237838
165deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.32682318
166rRNA methylation (GO:0031167)2.30570216
167signal peptide processing (GO:0006465)2.30488594
168NAD metabolic process (GO:0019674)2.29510962
169imidazole-containing compound metabolic process (GO:0052803)2.28709659
170pseudouridine synthesis (GO:0001522)2.27993983
171telomere maintenance (GO:0000723)2.27847586
172replication fork processing (GO:0031297)2.26959527
173GPI anchor biosynthetic process (GO:0006506)2.25233521
174ether lipid metabolic process (GO:0046485)2.24717633
175response to interferon-beta (GO:0035456)2.24564193
176telomere organization (GO:0032200)2.24345338
177nucleobase biosynthetic process (GO:0046112)2.24270723
178regulation of hexokinase activity (GO:1903299)2.22101339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.92058687
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.58892045
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35786316
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20062163
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.17250206
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.07556768
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85945567
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83285696
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.60206686
10AR_21909140_ChIP-Seq_LNCAP_Human2.55026309
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.45819594
12* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35064004
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29151436
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.28422573
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.27463164
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24161812
17* XRN2_22483619_ChIP-Seq_HELA_Human2.24150716
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22037752
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.21799380
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18376747
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.16033663
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15464442
23TTF2_22483619_ChIP-Seq_HELA_Human2.14484619
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12259673
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07948256
26* GABP_17652178_ChIP-ChIP_JURKAT_Human2.07302771
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.03622231
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02316284
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01675696
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95800675
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94780020
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89481197
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.88137327
34* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88098323
35* GABP_19822575_ChIP-Seq_HepG2_Human1.87498598
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.86228278
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84535346
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.84244452
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.83102540
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.81217387
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80051692
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79302993
43IRF1_19129219_ChIP-ChIP_H3396_Human1.79075041
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77989693
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77309174
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77015965
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74447149
48* VDR_23849224_ChIP-Seq_CD4+_Human1.71705110
49FOXP3_21729870_ChIP-Seq_TREG_Human1.69957441
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69638843
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69525449
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68697871
53* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66022816
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.63579242
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61415503
56FUS_26573619_Chip-Seq_HEK293_Human1.56629244
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56512830
58STAT3_18555785_Chip-Seq_ESCs_Mouse1.55045847
59KDM5A_27292631_Chip-Seq_BREAST_Human1.53048234
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52348900
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.52230190
62GBX2_23144817_ChIP-Seq_PC3_Human1.51097276
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48856679
64P53_22387025_ChIP-Seq_ESCs_Mouse1.48044293
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47958385
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.47229996
67P300_18555785_Chip-Seq_ESCs_Mouse1.46128210
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.45816441
69EWS_26573619_Chip-Seq_HEK293_Human1.44414873
70TAF15_26573619_Chip-Seq_HEK293_Human1.44345550
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.44194169
72HTT_18923047_ChIP-ChIP_STHdh_Human1.44161980
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41688627
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39617444
75RUNX1_27457419_Chip-Seq_LIVER_Mouse1.39325997
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38908755
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38424605
78OCT4_18555785_Chip-Seq_ESCs_Mouse1.37329822
79ZNF263_19887448_ChIP-Seq_K562_Human1.36397647
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35419853
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.31747312
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31658020
83SOX2_18555785_Chip-Seq_ESCs_Mouse1.31284673
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.31164086
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31095228
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.28803445
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28400408
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28292011
89* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27255405
90* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26687466
91SMAD1_18555785_Chip-Seq_ESCs_Mouse1.25143433
92* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25094853
93* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24768435
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23559932
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.23230405
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23017178
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21826813
98ZFX_18555785_Chip-Seq_ESCs_Mouse1.21814055
99ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20847853
100P300_19829295_ChIP-Seq_ESCs_Human1.20540581
101KLF4_18555785_Chip-Seq_ESCs_Mouse1.18547294
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.18480295
103MYC_18940864_ChIP-ChIP_HL60_Human1.17757134
104DCP1A_22483619_ChIP-Seq_HELA_Human1.17186809
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.15450154
106PU1_27457419_Chip-Seq_LIVER_Mouse1.15438609
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14400096
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14321798
109ESRRB_18555785_Chip-Seq_ESCs_Mouse1.13857109
110E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13712669
111* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11374752
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11297762
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10827988
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10692970
115NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10442456
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10311590
117SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09019777
118* SOX17_20123909_ChIP-Seq_XEN_Mouse1.08782688
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08211027
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07525889
121TFEB_21752829_ChIP-Seq_HELA_Human1.07288390
122SCL_19346495_ChIP-Seq_HPC-7_Human1.06952155
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.06364313
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06247078
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05597868
126* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05385661
127GATA1_22025678_ChIP-Seq_K562_Human1.05049244
128CTCF_18555785_Chip-Seq_ESCs_Mouse1.04811968
129YY1_21170310_ChIP-Seq_MESCs_Mouse1.04194592
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00655764
131SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99409818
132EGR1_19374776_ChIP-ChIP_THP-1_Human0.98061647
133ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97609232
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95786708
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94500921
136CIITA_25753668_ChIP-Seq_RAJI_Human0.91371225
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88481932
138CHD1_26751641_Chip-Seq_LNCaP_Human0.87943473
139CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87448017
140* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85277604
141TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81731622
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79506886
143ELK1_22589737_ChIP-Seq_MCF10A_Human0.79085236
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78388816
145CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75739212
146NANOG_16153702_ChIP-ChIP_HESCs_Human0.74747755
147TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70986723
148GATA4_21415370_ChIP-Seq_HL-1_Mouse0.70462137
149* ELF5_23300383_ChIP-Seq_T47D_Human0.67766442
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65721296
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65524862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.97161598
2MP0009697_abnormal_copulation4.14344223
3MP0005360_urolithiasis3.52719670
4MP0002139_abnormal_hepatobiliary_system3.42655266
5MP0005085_abnormal_gallbladder_physiolo3.27591005
6MP0006292_abnormal_olfactory_placode3.12385135
7MP0008932_abnormal_embryonic_tissue2.80700418
8MP0005365_abnormal_bile_salt2.76828220
9MP0008057_abnormal_DNA_replication2.70422252
10MP0008058_abnormal_DNA_repair2.54661412
11MP0001764_abnormal_homeostasis2.45220340
12MP0002876_abnormal_thyroid_physiology2.43184769
13MP0003787_abnormal_imprinting2.41713323
14MP0001188_hyperpigmentation2.31949274
15MP0005075_abnormal_melanosome_morpholog2.16963154
16MP0005379_endocrine/exocrine_gland_phen1.91685597
17MP0001730_embryonic_growth_arrest1.90918074
18MP0002138_abnormal_hepatobiliary_system1.88575570
19MP0006036_abnormal_mitochondrial_physio1.87057448
20MP0003693_abnormal_embryo_hatching1.86491098
21MP0003195_calcinosis1.81255901
22MP0008875_abnormal_xenobiotic_pharmacok1.80867889
23MP0001697_abnormal_embryo_size1.79166248
24MP0000350_abnormal_cell_proliferation1.76777317
25MP0003186_abnormal_redox_activity1.75629884
26MP0004233_abnormal_muscle_weight1.74420184
27MP0000015_abnormal_ear_pigmentation1.71402970
28MP0003941_abnormal_skin_development1.69356789
29MP0004147_increased_porphyrin_level1.64527174
30MP0005380_embryogenesis_phenotype1.61659074
31MP0001672_abnormal_embryogenesis/_devel1.61659074
32MP0001835_abnormal_antigen_presentation1.61359393
33MP0005671_abnormal_response_to1.55608628
34MP0000372_irregular_coat_pigmentation1.55398096
35MP0003984_embryonic_growth_retardation1.55067513
36MP0002638_abnormal_pupillary_reflex1.52626892
37MP0002132_abnormal_respiratory_system1.51755682
38MP0003890_abnormal_embryonic-extraembry1.51337108
39MP0010307_abnormal_tumor_latency1.51008744
40MP0002088_abnormal_embryonic_growth/wei1.48723726
41MP0002269_muscular_atrophy1.47683799
42MP0010094_abnormal_chromosome_stability1.47573894
43MP0002837_dystrophic_cardiac_calcinosis1.47307070
44MP0000358_abnormal_cell_content/1.45834362
45MP0005367_renal/urinary_system_phenotyp1.45718388
46MP0000516_abnormal_urinary_system1.45718388
47MP0009379_abnormal_foot_pigmentation1.45376832
48MP0002396_abnormal_hematopoietic_system1.44409863
49MP0002877_abnormal_melanocyte_morpholog1.44085879
50MP0004185_abnormal_adipocyte_glucose1.44021083
51MP0005408_hypopigmentation1.43333418
52MP0002080_prenatal_lethality1.43125257
53MP0002095_abnormal_skin_pigmentation1.42783148
54MP0001661_extended_life_span1.41819737
55MP0003221_abnormal_cardiomyocyte_apopto1.41419449
56MP0003252_abnormal_bile_duct1.40724638
57MP0009785_altered_susceptibility_to1.40085140
58MP0005409_darkened_coat_color1.37982920
59MP0003646_muscle_fatigue1.33679042
60MP0005451_abnormal_body_composition1.32320673
61MP0008007_abnormal_cellular_replicative1.31801245
62MP0008877_abnormal_DNA_methylation1.31501561
63MP0003868_abnormal_feces_composition1.31315943
64MP0005084_abnormal_gallbladder_morpholo1.31203255
65MP0005171_absent_coat_pigmentation1.28909520
66MP0005266_abnormal_metabolism1.28444866
67MP0002084_abnormal_developmental_patter1.26832656
68MP0006035_abnormal_mitochondrial_morpho1.26020571
69MP0003950_abnormal_plasma_membrane1.25780576
70MP0000313_abnormal_cell_death1.24931183
71MP0004019_abnormal_vitamin_homeostasis1.22237426
72MP0003121_genomic_imprinting1.22027225
73MP0001986_abnormal_taste_sensitivity1.19620342
74MP0001905_abnormal_dopamine_level1.19593665
75MP0003111_abnormal_nucleus_morphology1.19474141
76MP0010352_gastrointestinal_tract_polyps1.14657796
77MP0001293_anophthalmia1.11213881
78MP0002086_abnormal_extraembryonic_tissu1.10820283
79MP0001529_abnormal_vocalization1.10709615
80MP0005332_abnormal_amino_acid1.10514999
81MP0002085_abnormal_embryonic_tissue1.10494098
82MP0005174_abnormal_tail_pigmentation1.10002479
83MP0004145_abnormal_muscle_electrophysio1.07178314
84MP0005330_cardiomyopathy1.06042950
85MP0004957_abnormal_blastocyst_morpholog1.05682947
86MP0000747_muscle_weakness1.04707042
87MP0001929_abnormal_gametogenesis1.02268155
88MP0003937_abnormal_limbs/digits/tail_de0.99019558
89MP0009672_abnormal_birth_weight0.98613003
90MP0004381_abnormal_hair_follicle0.98502238
91MP0003077_abnormal_cell_cycle0.98049604
92MP0003011_delayed_dark_adaptation0.97386563
93MP0004197_abnormal_fetal_growth/weight/0.97346262
94MP0003718_maternal_effect0.96821837
95MP0003656_abnormal_erythrocyte_physiolo0.96361285
96MP0002160_abnormal_reproductive_system0.95794590
97MP0005647_abnormal_sex_gland0.95425339
98MP0003123_paternal_imprinting0.91910080
99MP0001324_abnormal_eye_pigmentation0.91546389
100MP0002148_abnormal_hypersensitivity_rea0.91081633
101MP0001119_abnormal_female_reproductive0.91001504
102MP0002019_abnormal_tumor_incidence0.89872533
103MP0005025_abnormal_response_to0.88949739
104MP0004782_abnormal_surfactant_physiolog0.88715531
105MP0009765_abnormal_xenobiotic_induced0.88584949
106MP0003567_abnormal_fetal_cardiomyocyte0.88163371
107MP0001881_abnormal_mammary_gland0.88053706
108MP0009763_increased_sensitivity_to0.86938114
109MP0008995_early_reproductive_senescence0.86104026
110MP0000749_muscle_degeneration0.86073912
111MP0002163_abnormal_gland_morphology0.83475900
112MP0003724_increased_susceptibility_to0.83332454
113MP0003136_yellow_coat_color0.83202283
114MP0006276_abnormal_autonomic_nervous0.82962779
115MP0005376_homeostasis/metabolism_phenot0.82760244
116MP0005551_abnormal_eye_electrophysiolog0.82610611
117MP0001727_abnormal_embryo_implantation0.82181853
118MP0005584_abnormal_enzyme/coenzyme_acti0.82044971
119MP0004808_abnormal_hematopoietic_stem0.81195488
120MP0000538_abnormal_urinary_bladder0.80104835
121MP0010234_abnormal_vibrissa_follicle0.80091489
122MP0005646_abnormal_pituitary_gland0.79880981
123MP0002009_preneoplasia0.78322142
124MP0003786_premature_aging0.77876953
125MP0003315_abnormal_perineum_morphology0.77370672
126MP0000490_abnormal_crypts_of0.77070882
127MP0001145_abnormal_male_reproductive0.76940995
128MP0001853_heart_inflammation0.75978983
129MP0005319_abnormal_enzyme/_coenzyme0.75765848
130MP0004215_abnormal_myocardial_fiber0.75671774
131MP0004087_abnormal_muscle_fiber0.73133887
132MP0001186_pigmentation_phenotype0.72950870
133MP0005535_abnormal_body_temperature0.72374330
134MP0003943_abnormal_hepatobiliary_system0.71227335
135MP0002419_abnormal_innate_immunity0.70678992
136MP0002277_abnormal_respiratory_mucosa0.70109375
137MP0002210_abnormal_sex_determination0.69609809
138MP0008469_abnormal_protein_level0.69594806
139MP0008775_abnormal_heart_ventricle0.69377159
140MP0000653_abnormal_sex_gland0.68472725
141MP0010155_abnormal_intestine_physiology0.67774873
142MP0010386_abnormal_urinary_bladder0.66261876
143MP0002697_abnormal_eye_size0.66057394
144MP0005384_cellular_phenotype0.65661689
145MP0001666_abnormal_nutrient_absorption0.65259885
146MP0002938_white_spotting0.63695494
147MP0000678_abnormal_parathyroid_gland0.63131210
148MP0004264_abnormal_extraembryonic_tissu0.63111856
149MP0010630_abnormal_cardiac_muscle0.62963559
150MP0005501_abnormal_skin_physiology0.62010988
151MP0002075_abnormal_coat/hair_pigmentati0.61969354
152MP0001800_abnormal_humoral_immune0.61273147
153MP0004084_abnormal_cardiac_muscle0.61176812
154MP0003763_abnormal_thymus_physiology0.60811458
155MP0005636_abnormal_mineral_homeostasis0.60633341
156MP0001286_abnormal_eye_development0.60500751
157MP0000689_abnormal_spleen_morphology0.60158258
158MP0004142_abnormal_muscle_tone0.59261480
159MP0005464_abnormal_platelet_physiology0.58970752
160MP0001873_stomach_inflammation0.56470191
161MP0003699_abnormal_female_reproductive0.55197234

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.27984163
2Reticulocytopenia (HP:0001896)4.14658100
3Acute encephalopathy (HP:0006846)3.97962246
4Renal cortical cysts (HP:0000803)3.92411565
5Abnormal mitochondria in muscle tissue (HP:0008316)3.88120549
6Increased CSF lactate (HP:0002490)3.72861155
7Increased serum pyruvate (HP:0003542)3.72159477
8Mitochondrial inheritance (HP:0001427)3.65034627
9Progressive macrocephaly (HP:0004481)3.45905280
10Abnormality of glycolysis (HP:0004366)3.41299314
11Macrocytic anemia (HP:0001972)3.38239198
12Cerebral edema (HP:0002181)3.27999398
13Abnormality of cells of the erythroid lineage (HP:0012130)3.24983993
14Lipid accumulation in hepatocytes (HP:0006561)3.20307241
15Increased hepatocellular lipid droplets (HP:0006565)3.16786927
16Conjugated hyperbilirubinemia (HP:0002908)3.14301984
17Abnormality of methionine metabolism (HP:0010901)3.13181226
18Progressive muscle weakness (HP:0003323)3.06836772
19Hepatic necrosis (HP:0002605)3.03604576
20Hepatocellular necrosis (HP:0001404)2.99211133
21Abnormality of chromosome stability (HP:0003220)2.98169505
22Renal Fanconi syndrome (HP:0001994)2.94180780
233-Methylglutaconic aciduria (HP:0003535)2.89428320
24Prolonged partial thromboplastin time (HP:0003645)2.87117704
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86625961
26Lactic acidosis (HP:0003128)2.79171151
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76951946
28Chromsome breakage (HP:0040012)2.72921994
29Progressive external ophthalmoplegia (HP:0000590)2.70049898
30Pallor (HP:0000980)2.68213319
31Increased serum lactate (HP:0002151)2.67398875
32Type I transferrin isoform profile (HP:0003642)2.65243080
33Intrahepatic cholestasis (HP:0001406)2.63143388
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60924093
35Dicarboxylic aciduria (HP:0003215)2.58152431
36Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58152431
37Abnormal number of erythroid precursors (HP:0012131)2.56229474
38Multiple enchondromatosis (HP:0005701)2.55980882
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.53571558
40Methylmalonic acidemia (HP:0002912)2.46964156
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.44596087
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43552986
43Reduced antithrombin III activity (HP:0001976)2.42066139
44Volvulus (HP:0002580)2.41792925
45Methylmalonic aciduria (HP:0012120)2.40223136
46Myelodysplasia (HP:0002863)2.39966581
47Fair hair (HP:0002286)2.39560180
48Palpitations (HP:0001962)2.38623924
49Poikiloderma (HP:0001029)2.37997152
50Abnormality of fatty-acid metabolism (HP:0004359)2.37802605
51Meckel diverticulum (HP:0002245)2.37118373
52Abnormality of the preputium (HP:0100587)2.30203015
53Abnormality of placental membranes (HP:0011409)2.30125584
54Amniotic constriction ring (HP:0009775)2.30125584
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.29445814
56Nemaline bodies (HP:0003798)2.28232892
57Abnormality of reticulocytes (HP:0004312)2.28113811
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26687415
59Abnormality of the ileum (HP:0001549)2.26673910
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23366795
61Abnormality of alanine metabolism (HP:0010916)2.23366795
62Hyperalaninemia (HP:0003348)2.23366795
63Abnormality of the renal cortex (HP:0011035)2.22976834
64Optic disc pallor (HP:0000543)2.22224200
65Premature ovarian failure (HP:0008209)2.21750110
66Microvesicular hepatic steatosis (HP:0001414)2.21498647
67Exercise intolerance (HP:0003546)2.21387161
68Abnormality of renal resorption (HP:0011038)2.21258604
69Respiratory difficulties (HP:0002880)2.20918063
70Birth length less than 3rd percentile (HP:0003561)2.18158823
71Exercise-induced muscle cramps (HP:0003710)2.18015106
72Nephroblastoma (Wilms tumor) (HP:0002667)2.16107229
73Abnormality of serum amino acid levels (HP:0003112)2.15433403
74Muscle fiber inclusion bodies (HP:0100299)2.15312986
75Lethargy (HP:0001254)2.15015932
76Abnormality of DNA repair (HP:0003254)2.13409709
77Short tibia (HP:0005736)2.12758373
78Hyperglycinemia (HP:0002154)2.12038695
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11580701
80Abnormal protein N-linked glycosylation (HP:0012347)2.11580701
81Abnormal protein glycosylation (HP:0012346)2.11580701
82Abnormal glycosylation (HP:0012345)2.11580701
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.10928200
84Joint hemorrhage (HP:0005261)2.10823850
85Rhabdomyosarcoma (HP:0002859)2.10629353
86Delayed CNS myelination (HP:0002188)2.10570769
87Increased nuchal translucency (HP:0010880)2.09532763
88Aplastic anemia (HP:0001915)2.07619413
89Myoglobinuria (HP:0002913)2.07457304
90Abnormality of pyrimidine metabolism (HP:0004353)2.07176121
91Chronic hepatic failure (HP:0100626)2.04054799
92Sensory axonal neuropathy (HP:0003390)2.03375680
93Acute myeloid leukemia (HP:0004808)2.02655849
94Duodenal stenosis (HP:0100867)2.02636854
95Small intestinal stenosis (HP:0012848)2.02636854
96Gingival bleeding (HP:0000225)2.02079712
97Increased intramyocellular lipid droplets (HP:0012240)2.00772457
98Abnormality of homocysteine metabolism (HP:0010919)1.99823094
99Homocystinuria (HP:0002156)1.99823094
100Abnormal lung lobation (HP:0002101)1.99677136
101Respiratory failure (HP:0002878)1.99319192
102Aplasia/Hypoplasia of the tibia (HP:0005772)1.99230036
103Tubulointerstitial nephritis (HP:0001970)1.99159915
104Hypochromic microcytic anemia (HP:0004840)1.98822656
105Limb hypertonia (HP:0002509)1.98320193
106Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97848753
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97848753
108Glycosuria (HP:0003076)1.97410494
109Abnormality of urine glucose concentration (HP:0011016)1.97410494
110Embryonal renal neoplasm (HP:0011794)1.96599144
111True hermaphroditism (HP:0010459)1.95907039
112Overlapping toe (HP:0001845)1.95738086
113Abnormality of the vitamin B12 metabolism (HP:0004341)1.95466922
114Metabolic acidosis (HP:0001942)1.94828617
115Hypothermia (HP:0002045)1.93113058
116Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92999850
117Osteomalacia (HP:0002749)1.92146318
118Sloping forehead (HP:0000340)1.91444665
119Rhabdomyolysis (HP:0003201)1.90631312
120Exertional dyspnea (HP:0002875)1.90438214
121Increased muscle lipid content (HP:0009058)1.90248298
122Hypobetalipoproteinemia (HP:0003563)1.89800106
123Abnormality of cochlea (HP:0000375)1.87040770
124Spontaneous abortion (HP:0005268)1.86658570
125Abnormality of vitamin B metabolism (HP:0004340)1.86097060
126Abnormality of the intrinsic pathway (HP:0010989)1.85772741
127Horseshoe kidney (HP:0000085)1.84930261
128Neoplasm of the colon (HP:0100273)1.84338826
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.84330410
130Secondary amenorrhea (HP:0000869)1.84060443
131Hyperventilation (HP:0002883)1.83593296
132Hyperglycinuria (HP:0003108)1.83188954
133Thyroid-stimulating hormone excess (HP:0002925)1.82727580
134Pancreatic fibrosis (HP:0100732)1.81909031
135Enlarged kidneys (HP:0000105)1.81698091
136Generalized hypopigmentation of hair (HP:0011358)1.79569035
137Leukodystrophy (HP:0002415)1.77942910
138Dyschromatopsia (HP:0007641)1.76972243
139Hyperammonemia (HP:0001987)1.75365385
140Duplicated collecting system (HP:0000081)1.74836556
141Xerostomia (HP:0000217)1.73540239
142Impulsivity (HP:0100710)1.73254985
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72208254
144Ragged-red muscle fibers (HP:0003200)1.71970924
145Hypoglycemic coma (HP:0001325)1.71400658
146Renal tubular dysfunction (HP:0000124)1.70709673
147Colon cancer (HP:0003003)1.70562370
148Neoplasm of the small intestine (HP:0100833)1.70484790
149Pancytopenia (HP:0001876)1.69653695
150Neoplasm of the rectum (HP:0100743)1.69459570
151Abnormal tarsal ossification (HP:0008369)1.69243829
152Megaloblastic anemia (HP:0001889)1.67026937
153Biliary tract neoplasm (HP:0100574)1.66825780
154Ependymoma (HP:0002888)1.66300562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.62926549
2ZAK3.59480292
3STK162.66737358
4MUSK2.64749487
5SRPK12.50161800
6IRAK42.38279303
7PIK3CA2.35043344
8SCYL22.24174018
9TNIK2.24115790
10NEK62.21803218
11IRAK32.21516461
12ERBB32.11967172
13TXK1.96295776
14YES11.93552148
15EIF2AK11.87057682
16PBK1.80131798
17FLT31.78592100
18CASK1.75115922
19OBSCN1.72221790
20MKNK11.71486807
21VRK11.69656072
22RPS6KB21.68904014
23MAP3K141.65127559
24MKNK21.64001023
25MST1R1.63366360
26EEF2K1.49148879
27AKT31.47521290
28TTK1.46741938
29BMPR21.44455884
30NEK21.40151602
31EIF2AK21.38863086
32TEC1.37486271
33NUAK11.35362809
34WNK41.35195412
35PLK41.33982413
36ADRBK21.25530056
37MAP2K71.25361498
38MYLK1.21291983
39WEE11.19945014
40STK31.17221086
41VRK21.16805771
42ATR1.15941993
43CHEK11.14909074
44INSRR1.12559321
45NME21.12083240
46EIF2AK31.10750831
47PDK21.10205198
48ALK1.10193505
49BRD41.06821184
50MAP3K121.06322324
51GRK71.03969720
52PIK3CG1.03150714
53TAOK31.00418614
54STK240.99587162
55BRAF0.97986244
56SGK20.97048365
57IKBKE0.94989314
58STK40.94099880
59PINK10.93684712
60KIT0.91099022
61NEK90.89798900
62LATS20.89123266
63IKBKB0.89076262
64SIK30.87881650
65BCKDK0.87021881
66BCR0.85618640
67MAP3K80.85536215
68BMPR1B0.84882593
69TYK20.82803476
70BRSK10.82664498
71BRSK20.82275448
72TRPM70.80556431
73PNCK0.78785385
74PRPF4B0.77115804
75CCNB10.76260934
76CDK120.74927799
77CDK70.74771296
78CDK30.73175380
79CSNK1E0.71792162
80LYN0.71704887
81PLK10.70925758
82PLK30.70578691
83MET0.69660240
84IRAK20.67993936
85JAK30.67739769
86CDK10.67687569
87STK390.67576001
88STK38L0.65973278
89MAPK130.65353240
90NME10.64624363
91RPS6KB10.64599852
92RAF10.63488767
93CDK80.63389319
94BTK0.63025011
95CSF1R0.62666993
96PIM10.62030135
97BUB10.61934466
98MAPKAPK50.61337724
99CDK20.61079102
100TAF10.60887914
101ATM0.58936111
102CDC70.58712990
103TAOK20.58470269
104MAPK70.57229053
105GRK10.57150725
106CSNK2A10.56505580
107TRIM280.56471431
108RPS6KA40.55782383
109AURKA0.55594671
110LATS10.54946481
111KSR10.54514581
112PASK0.51189345
113IRAK10.50817306
114PLK20.50574007
115CHEK20.49402055
116WNK10.49043215
117AURKB0.48990152
118PHKG10.48246838
119PHKG20.48246838
120CDK40.48203067
121PKN10.47933803
122FGFR10.47365953
123SYK0.47241213
124CLK10.47057949
125AKT20.45620962
126MST40.45480448
127NLK0.43868515
128STK100.43200165
129PRKCI0.41891964
130PRKG10.40551371
131CHUK0.38162519
132MAP3K90.37963854
133ERBB40.37869666
134JAK10.37284175
135DYRK20.37265406
136PRKCQ0.36671241
137TSSK60.36485895
138PRKDC0.35711203
139CSNK2A20.33739698
140LCK0.33274759
141ARAF0.31328737
142MAP3K100.30309311
143PAK40.29790174
144MAPK140.29040546
145BMX0.28703707
146MAP2K60.28692239
147KSR20.24452580
148PRKACB0.23235706

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.63327219
2Sulfur metabolism_Homo sapiens_hsa009202.42751829
3Parkinsons disease_Homo sapiens_hsa050122.26380868
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21962831
5Propanoate metabolism_Homo sapiens_hsa006402.20905240
6Mismatch repair_Homo sapiens_hsa034302.13999985
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.08468931
8One carbon pool by folate_Homo sapiens_hsa006702.03601228
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.99042326
10Selenocompound metabolism_Homo sapiens_hsa004501.86538115
11Peroxisome_Homo sapiens_hsa041461.83274347
12Fatty acid elongation_Homo sapiens_hsa000621.79252916
13DNA replication_Homo sapiens_hsa030301.78370209
14Proteasome_Homo sapiens_hsa030501.75757476
15Huntingtons disease_Homo sapiens_hsa050161.74483914
16Homologous recombination_Homo sapiens_hsa034401.74061112
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73701059
18RNA polymerase_Homo sapiens_hsa030201.72727791
19Pyrimidine metabolism_Homo sapiens_hsa002401.69970693
20Alzheimers disease_Homo sapiens_hsa050101.66799568
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66690597
22Nucleotide excision repair_Homo sapiens_hsa034201.63726446
23Fanconi anemia pathway_Homo sapiens_hsa034601.61063560
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60758370
25Base excision repair_Homo sapiens_hsa034101.59599149
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.58104323
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.56911381
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55056400
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.52890141
30RNA degradation_Homo sapiens_hsa030181.48698958
31Fatty acid degradation_Homo sapiens_hsa000711.47809382
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44573250
33Tryptophan metabolism_Homo sapiens_hsa003801.44070185
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43374611
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42897066
36Basal transcription factors_Homo sapiens_hsa030221.42787441
37Ribosome_Homo sapiens_hsa030101.42368768
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41422296
39Protein export_Homo sapiens_hsa030601.40813883
40Non-homologous end-joining_Homo sapiens_hsa034501.40078564
41Biosynthesis of amino acids_Homo sapiens_hsa012301.39882315
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36385954
43mRNA surveillance pathway_Homo sapiens_hsa030151.35997261
44beta-Alanine metabolism_Homo sapiens_hsa004101.32983544
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31825998
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29052909
47Histidine metabolism_Homo sapiens_hsa003401.28581774
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28292903
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24251977
50Spliceosome_Homo sapiens_hsa030401.16877568
51Retinol metabolism_Homo sapiens_hsa008301.14675590
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13381206
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10770108
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09893566
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09053652
56Purine metabolism_Homo sapiens_hsa002301.08088841
57Tyrosine metabolism_Homo sapiens_hsa003501.03582721
58Phenylalanine metabolism_Homo sapiens_hsa003601.03159525
59Chemical carcinogenesis_Homo sapiens_hsa052041.02025795
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.00219307
61Complement and coagulation cascades_Homo sapiens_hsa046101.00087185
62Metabolic pathways_Homo sapiens_hsa011000.99727394
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98248953
64Pyruvate metabolism_Homo sapiens_hsa006200.97159621
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94672938
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94562445
67Butanoate metabolism_Homo sapiens_hsa006500.94228756
68Fatty acid metabolism_Homo sapiens_hsa012120.91989576
69ABC transporters_Homo sapiens_hsa020100.88749833
70Folate biosynthesis_Homo sapiens_hsa007900.88617217
71Steroid biosynthesis_Homo sapiens_hsa001000.87532962
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.86891285
73Carbon metabolism_Homo sapiens_hsa012000.86555552
74Pentose phosphate pathway_Homo sapiens_hsa000300.85785896
75Systemic lupus erythematosus_Homo sapiens_hsa053220.85273447
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81906733
77Starch and sucrose metabolism_Homo sapiens_hsa005000.80264225
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78408368
79Vitamin digestion and absorption_Homo sapiens_hsa049770.77159694
80Primary immunodeficiency_Homo sapiens_hsa053400.75259379
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74568521
82Phototransduction_Homo sapiens_hsa047440.69800132
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69738685
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69324271
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.67890371
86RNA transport_Homo sapiens_hsa030130.67325454
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67065436
88p53 signaling pathway_Homo sapiens_hsa041150.66410551
89Herpes simplex infection_Homo sapiens_hsa051680.65698468
90Autoimmune thyroid disease_Homo sapiens_hsa053200.64363672
91Arachidonic acid metabolism_Homo sapiens_hsa005900.64140875
92Sulfur relay system_Homo sapiens_hsa041220.63425868
93Allograft rejection_Homo sapiens_hsa053300.61616782
94Staphylococcus aureus infection_Homo sapiens_hsa051500.61425247
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61289774
96Oocyte meiosis_Homo sapiens_hsa041140.60926787
97Fructose and mannose metabolism_Homo sapiens_hsa000510.60604106
98Arginine and proline metabolism_Homo sapiens_hsa003300.57756170
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57744730
100Glutathione metabolism_Homo sapiens_hsa004800.57279993
101N-Glycan biosynthesis_Homo sapiens_hsa005100.56537925
102Cardiac muscle contraction_Homo sapiens_hsa042600.56290853
103Galactose metabolism_Homo sapiens_hsa000520.56105069
104Thyroid cancer_Homo sapiens_hsa052160.54822417
105Cell cycle_Homo sapiens_hsa041100.52186653
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.51100460
107Measles_Homo sapiens_hsa051620.49948902
108Vitamin B6 metabolism_Homo sapiens_hsa007500.49487556
109Lysine degradation_Homo sapiens_hsa003100.46259886
110Caffeine metabolism_Homo sapiens_hsa002320.45153711
111PPAR signaling pathway_Homo sapiens_hsa033200.44466319
112Linoleic acid metabolism_Homo sapiens_hsa005910.41775311
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41506927
114Arginine biosynthesis_Homo sapiens_hsa002200.39950625
115Hematopoietic cell lineage_Homo sapiens_hsa046400.39633730
116Nitrogen metabolism_Homo sapiens_hsa009100.36465242
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33604773
118Epstein-Barr virus infection_Homo sapiens_hsa051690.30389536
119Fat digestion and absorption_Homo sapiens_hsa049750.28865885
120Viral carcinogenesis_Homo sapiens_hsa052030.21777716
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15020805
122Fatty acid biosynthesis_Homo sapiens_hsa000610.13820646
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.08374526

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