MTIF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)6.29103120
2ATP synthesis coupled proton transport (GO:0015986)6.29103120
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.22627174
4respiratory electron transport chain (GO:0022904)5.78425800
5electron transport chain (GO:0022900)5.69927340
6L-phenylalanine metabolic process (GO:0006558)5.39455951
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.39455951
8L-phenylalanine catabolic process (GO:0006559)5.19692648
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.19692648
10aromatic amino acid family catabolic process (GO:0009074)4.94089681
11indole-containing compound catabolic process (GO:0042436)4.68876384
12indolalkylamine catabolic process (GO:0046218)4.68876384
13tryptophan catabolic process (GO:0006569)4.68876384
14chaperone-mediated protein transport (GO:0072321)4.58897690
15tryptophan metabolic process (GO:0006568)4.48038504
16protein neddylation (GO:0045116)4.47734847
17glycine metabolic process (GO:0006544)4.32172140
18oxidative phosphorylation (GO:0006119)4.29740574
19platelet dense granule organization (GO:0060155)4.28403429
20kynurenine metabolic process (GO:0070189)4.25482665
21glyoxylate metabolic process (GO:0046487)4.25125677
22serine family amino acid catabolic process (GO:0009071)4.18256464
23cytochrome complex assembly (GO:0017004)4.14395547
24respiratory chain complex IV assembly (GO:0008535)4.13694244
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.08427951
26bile acid biosynthetic process (GO:0006699)4.07107067
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.01497636
28aldehyde catabolic process (GO:0046185)3.97783386
29cysteine metabolic process (GO:0006534)3.93771411
30hydrogen ion transmembrane transport (GO:1902600)3.90484466
31cellular ketone body metabolic process (GO:0046950)3.85989762
32serine family amino acid biosynthetic process (GO:0009070)3.85093901
33aromatic amino acid family metabolic process (GO:0009072)3.84168166
34serine family amino acid metabolic process (GO:0009069)3.82935265
35folic acid metabolic process (GO:0046655)3.79146993
36DNA deamination (GO:0045006)3.74608652
37heart contraction (GO:0060047)3.67711812
38heart process (GO:0003015)3.67711812
39proton transport (GO:0015992)3.67698830
40ATP biosynthetic process (GO:0006754)3.67176527
41cullin deneddylation (GO:0010388)3.66550952
42hydrogen transport (GO:0006818)3.64124633
43amino-acid betaine metabolic process (GO:0006577)3.62649682
44lysine metabolic process (GO:0006553)3.56761386
45lysine catabolic process (GO:0006554)3.56761386
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56686011
47regulation of mitochondrial translation (GO:0070129)3.55426247
48proteasome assembly (GO:0043248)3.54391684
49sulfur amino acid catabolic process (GO:0000098)3.52395900
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.52293106
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52050237
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.48645388
53urea metabolic process (GO:0019627)3.48497024
54urea cycle (GO:0000050)3.48497024
55negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.48234316
56regulation of cholesterol esterification (GO:0010872)3.47309532
57high-density lipoprotein particle remodeling (GO:0034375)3.46759131
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.46137159
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45487532
60cellular biogenic amine catabolic process (GO:0042402)3.45409249
61amine catabolic process (GO:0009310)3.45409249
62water-soluble vitamin biosynthetic process (GO:0042364)3.44861110
63alpha-amino acid catabolic process (GO:1901606)3.36732053
64protein deneddylation (GO:0000338)3.35670829
65sulfur amino acid biosynthetic process (GO:0000097)3.34172885
66bile acid metabolic process (GO:0008206)3.33398145
67nitrogen cycle metabolic process (GO:0071941)3.29703764
68ketone body metabolic process (GO:1902224)3.29434966
69indolalkylamine metabolic process (GO:0006586)3.27570206
70ribosomal large subunit biogenesis (GO:0042273)3.27347238
71viral transcription (GO:0019083)3.24644458
72L-serine metabolic process (GO:0006563)3.24152289
73homocysteine metabolic process (GO:0050667)3.17971330
74L-methionine salvage (GO:0071267)3.17906695
75L-methionine biosynthetic process (GO:0071265)3.17906695
76amino acid salvage (GO:0043102)3.17906695
77translational termination (GO:0006415)3.15119915
78aerobic respiration (GO:0009060)3.13634056
79maturation of SSU-rRNA (GO:0030490)3.13143612
80methionine metabolic process (GO:0006555)3.13024719
81cellular amino acid catabolic process (GO:0009063)3.12946348
82ribosomal small subunit assembly (GO:0000028)3.11965731
83regulation of glucokinase activity (GO:0033131)3.10535801
84regulation of hexokinase activity (GO:1903299)3.10535801
85translation (GO:0006412)3.10453362
86protein complex biogenesis (GO:0070271)3.08914290
87negative regulation of fibrinolysis (GO:0051918)3.08391888
88NAD biosynthetic process (GO:0009435)3.08154433
89negative regulation of sterol transport (GO:0032372)3.06532519
90negative regulation of cholesterol transport (GO:0032375)3.06532519
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06053663
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05302431
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05302431
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04929716
95mitochondrial respiratory chain complex I assembly (GO:0032981)3.04929716
96NADH dehydrogenase complex assembly (GO:0010257)3.04929716
97regulation of fibrinolysis (GO:0051917)3.03462535
98xenobiotic catabolic process (GO:0042178)3.02864148
99branched-chain amino acid catabolic process (GO:0009083)3.02632309
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01478416
101tyrosine metabolic process (GO:0006570)3.01356957
102cotranslational protein targeting to membrane (GO:0006613)3.01152292
103ribosomal small subunit biogenesis (GO:0042274)3.00756343
104plasma lipoprotein particle remodeling (GO:0034369)2.98641000
105protein-lipid complex remodeling (GO:0034368)2.98641000
106macromolecular complex remodeling (GO:0034367)2.98641000
107S-adenosylmethionine metabolic process (GO:0046500)2.97946041
108sulfur amino acid metabolic process (GO:0000096)2.96865474
109protein targeting to ER (GO:0045047)2.96324686
110alpha-linolenic acid metabolic process (GO:0036109)2.94985959
111complement activation, alternative pathway (GO:0006957)2.94927355
112mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94256213
113imidazole-containing compound metabolic process (GO:0052803)2.94240097
114methionine biosynthetic process (GO:0009086)2.94126807
115pyridine nucleotide biosynthetic process (GO:0019363)2.93667370
116nicotinamide nucleotide biosynthetic process (GO:0019359)2.93667370
117phospholipid efflux (GO:0033700)2.93065454
118NAD metabolic process (GO:0019674)2.92427975
119protein targeting to mitochondrion (GO:0006626)2.92308325
120mitochondrial respiratory chain complex assembly (GO:0033108)2.91782483
121short-chain fatty acid metabolic process (GO:0046459)2.91628928
122termination of RNA polymerase III transcription (GO:0006386)2.90916682
123transcription elongation from RNA polymerase III promoter (GO:0006385)2.90916682
124ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89145340
125protein-cofactor linkage (GO:0018065)2.88456855
126carboxylic acid catabolic process (GO:0046395)2.87933541
127organic acid catabolic process (GO:0016054)2.87933541
128translational elongation (GO:0006414)2.85444116
129drug catabolic process (GO:0042737)2.85216972
130arginine metabolic process (GO:0006525)2.84746775
131ethanol oxidation (GO:0006069)2.84450940
132pteridine-containing compound metabolic process (GO:0042558)2.83761294
133cofactor catabolic process (GO:0051187)2.82561378
134protein localization to endoplasmic reticulum (GO:0070972)2.82334530
135regulation of protein activation cascade (GO:2000257)2.82024168
136inner mitochondrial membrane organization (GO:0007007)2.81668548
137benzene-containing compound metabolic process (GO:0042537)2.81521348
138carnitine metabolic process (GO:0009437)2.80966727
139aspartate family amino acid metabolic process (GO:0009066)2.80817777
140GTP biosynthetic process (GO:0006183)2.79512492
141translational initiation (GO:0006413)2.79241222
142mitochondrial transport (GO:0006839)2.78544442
143regulation of cellular amino acid metabolic process (GO:0006521)2.75633359
144establishment of protein localization to mitochondrion (GO:0072655)2.74761040
145epithelial cilium movement (GO:0003351)2.73985562
146protein localization to mitochondrion (GO:0070585)2.72998362
147cellular respiration (GO:0045333)2.71771608
148DNA double-strand break processing (GO:0000729)2.70569776
149anterograde synaptic vesicle transport (GO:0048490)2.69527748
150negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67326183
151cellular protein complex disassembly (GO:0043624)2.66419414
152rRNA modification (GO:0000154)2.65993175
153nucleoside triphosphate biosynthetic process (GO:0009142)2.64107506
154regulation of mitotic spindle checkpoint (GO:1903504)2.63887963
155regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63887963
156positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63083035
157viral life cycle (GO:0019058)2.62807741
158epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58335614
159positive regulation of prostaglandin secretion (GO:0032308)2.56051673
160glutathione derivative metabolic process (GO:1901685)2.51252336
161glutathione derivative biosynthetic process (GO:1901687)2.51252336
162ubiquinone biosynthetic process (GO:0006744)2.51175841
163cellular component biogenesis (GO:0044085)2.50208873
164DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50160337
165DNA damage response, detection of DNA damage (GO:0042769)2.49218710
166regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47169044
167purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.44876209
168purine nucleoside monophosphate biosynthetic process (GO:0009127)2.44876209
169pyrimidine nucleotide catabolic process (GO:0006244)2.44294779
170response to nitrosative stress (GO:0051409)2.42637251
171intraciliary transport (GO:0042073)2.42167440
172negative regulation of calcium ion transmembrane transport (GO:1903170)2.42065942
173negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.42065942
174ubiquinone metabolic process (GO:0006743)2.41911565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.25193011
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95992466
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.64991740
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62534859
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.54024780
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.52194930
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.49176203
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.40074574
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.28285398
10PPARA_22158963_ChIP-Seq_LIVER_Mouse3.20030578
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.06761377
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.04062818
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.00942719
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.92651700
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91379079
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89193939
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.77437616
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77082895
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.65122503
20E2F7_22180533_ChIP-Seq_HELA_Human2.53111554
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49180610
22VDR_22108803_ChIP-Seq_LS180_Human2.45272652
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45003446
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.44604435
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43662347
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.30683737
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.27182305
28* VDR_23849224_ChIP-Seq_CD4+_Human2.22743593
29LXR_22158963_ChIP-Seq_LIVER_Mouse2.22124343
30ZNF274_21170338_ChIP-Seq_K562_Hela2.16897607
31* FOXP3_21729870_ChIP-Seq_TREG_Human2.07585104
32DCP1A_22483619_ChIP-Seq_HELA_Human2.05590863
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05489856
34FLI1_27457419_Chip-Seq_LIVER_Mouse2.05201758
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04390931
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98216021
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96920653
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90262408
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89577206
40FUS_26573619_Chip-Seq_HEK293_Human1.89350449
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89095789
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88728327
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87579138
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.85476367
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82540354
46* GABP_19822575_ChIP-Seq_HepG2_Human1.82322454
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82125047
48XRN2_22483619_ChIP-Seq_HELA_Human1.81804973
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76967231
50EWS_26573619_Chip-Seq_HEK293_Human1.68026675
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65836970
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64880134
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61694888
54P300_19829295_ChIP-Seq_ESCs_Human1.60643109
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59237740
56GBX2_23144817_ChIP-Seq_PC3_Human1.59162163
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58805315
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.57518497
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56675983
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54024829
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52647878
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50229080
63TAF15_26573619_Chip-Seq_HEK293_Human1.49079561
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48987200
65HTT_18923047_ChIP-ChIP_STHdh_Human1.46860126
66MYC_18940864_ChIP-ChIP_HL60_Human1.46359219
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44969912
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43041254
69* TP53_22573176_ChIP-Seq_HFKS_Human1.42253200
70SOX2_19829295_ChIP-Seq_ESCs_Human1.38315744
71NANOG_19829295_ChIP-Seq_ESCs_Human1.38315744
72AR_20517297_ChIP-Seq_VCAP_Human1.37678434
73* IGF1R_20145208_ChIP-Seq_DFB_Human1.36338619
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36319191
75ER_23166858_ChIP-Seq_MCF-7_Human1.35228981
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34981560
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34846246
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32257715
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31739312
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.31549771
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.29727251
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29727251
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29624993
84TTF2_22483619_ChIP-Seq_HELA_Human1.28265034
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.26801352
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26443637
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24906105
88EZH2_22144423_ChIP-Seq_EOC_Human1.22622853
89BCAT_22108803_ChIP-Seq_LS180_Human1.20782813
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20597511
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19068948
92KDM5A_27292631_Chip-Seq_BREAST_Human1.19056278
93IRF8_22096565_ChIP-ChIP_GC-B_Human1.18359544
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18195105
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17534580
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14636106
97* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13823929
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13748855
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13545898
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12210523
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12147684
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.11812540
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11775640
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11564943
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09731016
106CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08961986
107MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08067496
108KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07916137
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04541848
110CBP_20019798_ChIP-Seq_JUKART_Human1.03486387
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03486387
112NCOR_22424771_ChIP-Seq_293T_Human1.02539905
113* ELK1_19687146_ChIP-ChIP_HELA_Human1.02165532
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02083797
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01335053
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00900451
117MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00665816
118ERG_20517297_ChIP-Seq_VCAP_Human1.00522319
119TCF4_22108803_ChIP-Seq_LS180_Human1.00477392
120CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00086989
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99733677
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99483802
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99256296
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98572417
125POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98134674
126BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98015981
127AR_25329375_ChIP-Seq_VCAP_Human0.97861933
128* GATA3_21878914_ChIP-Seq_MCF-7_Human0.96848483
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96428626
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95929878
131SALL4_22934838_ChIP-ChIP_CD34+_Human0.95627841
132* FOXH1_21741376_ChIP-Seq_EPCs_Human0.94988798
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94697531
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94588090
135PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94224153
136STAT3_18555785_Chip-Seq_ESCs_Mouse0.93886314
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93779802
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93305195
139P53_22387025_ChIP-Seq_ESCs_Mouse0.92707741
140ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92203249
141CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91617267
142* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88740706
143MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87841845
144NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87402682
145* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85898031
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85546039
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85534048
148CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85153068
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85077894
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84589186
151CTCF_26484167_Chip-Seq_Bcells_Mouse0.84220252
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84110722
153BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83938686
154RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83626335
155ELK1_22589737_ChIP-Seq_MCF10A_Human0.81415340
156NANOG_18555785_ChIP-Seq_MESCs_Mouse0.79880966
157RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78568195
158IRF1_19129219_ChIP-ChIP_H3396_Human0.78059078
159TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.77159730
160HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76763003
161NOTCH1_21737748_ChIP-Seq_TLL_Human0.76132584
162E2F1_21310950_ChIP-Seq_MCF-7_Human0.75961098
163TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74810156
164LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73338056
165SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73202756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.30356943
2MP0005360_urolithiasis6.17782125
3MP0005085_abnormal_gallbladder_physiolo4.75178162
4MP0005365_abnormal_bile_salt4.46322921
5MP0003806_abnormal_nucleotide_metabolis4.40151244
6MP0008875_abnormal_xenobiotic_pharmacok3.94828384
7MP0009840_abnormal_foam_cell3.07447063
8MP0004215_abnormal_myocardial_fiber2.95841262
9MP0003011_delayed_dark_adaptation2.82894609
10MP0005332_abnormal_amino_acid2.71069076
11MP0010329_abnormal_lipoprotein_level2.58820194
12MP0006072_abnormal_retinal_apoptosis2.52955467
13MP0001764_abnormal_homeostasis2.41309762
14MP0004145_abnormal_muscle_electrophysio2.40442482
15MP0005451_abnormal_body_composition2.34897172
16MP0002138_abnormal_hepatobiliary_system2.33124773
17MP0008877_abnormal_DNA_methylation2.30396467
18MP0006036_abnormal_mitochondrial_physio2.29675260
19MP0004084_abnormal_cardiac_muscle2.18382914
20MP0003186_abnormal_redox_activity2.15739959
21MP0002638_abnormal_pupillary_reflex2.14782405
22MP0003787_abnormal_imprinting2.13802789
23MP0004019_abnormal_vitamin_homeostasis2.13572535
24MP0003195_calcinosis2.12161354
25MP0006292_abnormal_olfactory_placode2.09847596
26MP0003252_abnormal_bile_duct2.06752593
27MP0001666_abnormal_nutrient_absorption1.88873137
28MP0005083_abnormal_biliary_tract1.85143243
29MP0003718_maternal_effect1.81452877
30MP0010386_abnormal_urinary_bladder1.80789244
31MP0004142_abnormal_muscle_tone1.77639969
32MP0005379_endocrine/exocrine_gland_phen1.74400566
33MP0003693_abnormal_embryo_hatching1.73221386
34MP0000609_abnormal_liver_physiology1.65841189
35MP0002102_abnormal_ear_morphology1.65311806
36MP0003137_abnormal_impulse_conducting1.64961926
37MP0008058_abnormal_DNA_repair1.62653166
38MP0001188_hyperpigmentation1.62601388
39MP0001984_abnormal_olfaction1.58771448
40MP0009697_abnormal_copulation1.56802303
41MP0004147_increased_porphyrin_level1.54193307
42MP0005319_abnormal_enzyme/_coenzyme1.54174751
43MP0005253_abnormal_eye_physiology1.51132093
44MP0009379_abnormal_foot_pigmentation1.50882114
45MP0003656_abnormal_erythrocyte_physiolo1.45751891
46MP0006035_abnormal_mitochondrial_morpho1.45680112
47MP0003121_genomic_imprinting1.45541030
48MP0002118_abnormal_lipid_homeostasis1.44972148
49MP0003191_abnormal_cellular_cholesterol1.43279449
50MP0008775_abnormal_heart_ventricle1.42410659
51MP0005636_abnormal_mineral_homeostasis1.41703460
52MP0003122_maternal_imprinting1.41249421
53MP0009643_abnormal_urine_homeostasis1.40889223
54MP0002277_abnormal_respiratory_mucosa1.39896597
55MP0004036_abnormal_muscle_relaxation1.37138053
56MP0001485_abnormal_pinna_reflex1.36864742
57MP0008872_abnormal_physiological_respon1.36854266
58MP0003868_abnormal_feces_composition1.34875075
59MP0005584_abnormal_enzyme/coenzyme_acti1.34013535
60MP0005330_cardiomyopathy1.32035327
61MP0001986_abnormal_taste_sensitivity1.30733055
62MP0000749_muscle_degeneration1.24321382
63MP0002272_abnormal_nervous_system1.24301747
64MP0002132_abnormal_respiratory_system1.24138507
65MP0010094_abnormal_chromosome_stability1.23661016
66MP0005084_abnormal_gallbladder_morpholo1.21566396
67MP0001905_abnormal_dopamine_level1.21467048
68MP0002938_white_spotting1.18579538
69MP0005645_abnormal_hypothalamus_physiol1.17427179
70MP0003880_abnormal_central_pattern1.16588910
71MP0006276_abnormal_autonomic_nervous1.14611975
72MP0002822_catalepsy1.10643892
73MP0003436_decreased_susceptibility_to1.08953128
74MP0003646_muscle_fatigue1.08676049
75MP0004742_abnormal_vestibular_system1.06753645
76MP0008469_abnormal_protein_level1.06077789
77MP0004957_abnormal_blastocyst_morpholog1.03896773
78MP0009765_abnormal_xenobiotic_induced1.03697290
79MP0000598_abnormal_liver_morphology1.01723696
80MP0002876_abnormal_thyroid_physiology1.01614891
81MP0004043_abnormal_pH_regulation1.01375033
82MP0001440_abnormal_grooming_behavior1.00058805
83MP0003724_increased_susceptibility_to1.00041830
84MP0004085_abnormal_heartbeat0.99347336
85MP0002928_abnormal_bile_duct0.98931697
86MP0004484_altered_response_of0.98894735
87MP0003111_abnormal_nucleus_morphology0.98591138
88MP0005535_abnormal_body_temperature0.96813193
89MP0005670_abnormal_white_adipose0.96579967
90MP0002396_abnormal_hematopoietic_system0.96221602
91MP0009763_increased_sensitivity_to0.95012838
92MP0008007_abnormal_cellular_replicative0.94623222
93MP0001544_abnormal_cardiovascular_syste0.94025364
94MP0005385_cardiovascular_system_phenoty0.94025364
95MP0001486_abnormal_startle_reflex0.93806189
96MP0003878_abnormal_ear_physiology0.93617595
97MP0005377_hearing/vestibular/ear_phenot0.93617595
98MP0001727_abnormal_embryo_implantation0.93374490
99MP0002234_abnormal_pharynx_morphology0.92905309
100MP0002127_abnormal_cardiovascular_syste0.92067286
101MP0009642_abnormal_blood_homeostasis0.91294731
102MP0004885_abnormal_endolymph0.91222883
103MP0005389_reproductive_system_phenotype0.89344120
104MP0008932_abnormal_embryonic_tissue0.88931138
105MP0009785_altered_susceptibility_to0.88463696
106MP0005408_hypopigmentation0.87767688
107MP0002163_abnormal_gland_morphology0.85540989
108MP0009046_muscle_twitch0.85434820
109MP0005075_abnormal_melanosome_morpholog0.85002847
110MP0009745_abnormal_behavioral_response0.84974482
111MP0001919_abnormal_reproductive_system0.84807572
112MP0005646_abnormal_pituitary_gland0.82793705
113MP0002972_abnormal_cardiac_muscle0.81787484
114MP0009764_decreased_sensitivity_to0.81359292
115MP0002090_abnormal_vision0.81241258
116MP0009672_abnormal_birth_weight0.79663476
117MP0003077_abnormal_cell_cycle0.79461905
118MP0000230_abnormal_systemic_arterial0.78447999
119MP0005376_homeostasis/metabolism_phenot0.76668036
120MP0005620_abnormal_muscle_contractility0.76529721
121MP0001968_abnormal_touch/_nociception0.76298468
122MP0004381_abnormal_hair_follicle0.73590235
123MP0005410_abnormal_fertilization0.73258965
124MP0001970_abnormal_pain_threshold0.73180593
125MP0003763_abnormal_thymus_physiology0.72738840
126MP0000427_abnormal_hair_cycle0.72736756
127MP0001756_abnormal_urination0.71163778
128MP0008873_increased_physiological_sensi0.70834326
129MP0000631_abnormal_neuroendocrine_gland0.70424300
130MP0009333_abnormal_splenocyte_physiolog0.70162082
131MP0002160_abnormal_reproductive_system0.69085167
132MP0002736_abnormal_nociception_after0.69065768
133MP0002837_dystrophic_cardiac_calcinosis0.68260761
134MP0002693_abnormal_pancreas_physiology0.67037780
135MP0005220_abnormal_exocrine_pancreas0.66739087
136MP0002078_abnormal_glucose_homeostasis0.65892021
137MP0005266_abnormal_metabolism0.64465889
138MP0005025_abnormal_response_to0.64359177
139MP0001835_abnormal_antigen_presentation0.64062854
140MP0004782_abnormal_surfactant_physiolog0.63057182
141MP0001119_abnormal_female_reproductive0.62034977
142MP0001800_abnormal_humoral_immune0.61993400
143MP0002136_abnormal_kidney_physiology0.61896962
144MP0000685_abnormal_immune_system0.61512524
145MP0000372_irregular_coat_pigmentation0.60983182
146MP0000358_abnormal_cell_content/0.59751690
147MP0002653_abnormal_ependyma_morphology0.58678174
148MP0005671_abnormal_response_to0.56709022
149MP0005551_abnormal_eye_electrophysiolog0.56668260
150MP0005395_other_phenotype0.55995282
151MP0001845_abnormal_inflammatory_respons0.55268582
152MP0002970_abnormal_white_adipose0.54264334
153MP0008789_abnormal_olfactory_epithelium0.53796255
154MP0001853_heart_inflammation0.52837536
155MP0002971_abnormal_brown_adipose0.52806987
156MP0001663_abnormal_digestive_system0.51550259
157MP0001661_extended_life_span0.50667442
158MP0001529_abnormal_vocalization0.49524676
159MP0001929_abnormal_gametogenesis0.49148328
160MP0002019_abnormal_tumor_incidence0.48739067
161MP0000689_abnormal_spleen_morphology0.48085861
162MP0005334_abnormal_fat_pad0.47987073
163MP0002429_abnormal_blood_cell0.47291567

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.91074179
2Intrahepatic cholestasis (HP:0001406)4.21672764
3Hypobetalipoproteinemia (HP:0003563)4.10626810
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.07197356
5Hyperglycinemia (HP:0002154)4.01459184
6Hepatic necrosis (HP:0002605)4.00215551
7Hepatocellular necrosis (HP:0001404)3.85696102
8Prolonged partial thromboplastin time (HP:0003645)3.77881930
9Abnormality of pyrimidine metabolism (HP:0004353)3.68626960
10Hyperglycinuria (HP:0003108)3.51838449
11Abnormality of serum amino acid levels (HP:0003112)3.45582627
12Acute encephalopathy (HP:0006846)3.44260089
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.40243405
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.40243405
15Hyperammonemia (HP:0001987)3.40194053
16Cerebral edema (HP:0002181)3.39338841
17Mitochondrial inheritance (HP:0001427)3.38199058
18Abnormality of methionine metabolism (HP:0010901)3.30794943
19Increased CSF lactate (HP:0002490)3.29077138
20Abnormality of glycine metabolism (HP:0010895)3.28708597
21Abnormality of serine family amino acid metabolism (HP:0010894)3.28708597
22Lethargy (HP:0001254)3.25546474
23Xanthomatosis (HP:0000991)3.22839512
24Acute necrotizing encephalopathy (HP:0006965)3.20076870
25Lipid accumulation in hepatocytes (HP:0006561)3.19336416
26Abnormal mitochondria in muscle tissue (HP:0008316)3.17711402
27Generalized aminoaciduria (HP:0002909)3.15371640
28Methylmalonic acidemia (HP:0002912)3.13877816
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.13125994
303-Methylglutaconic aciduria (HP:0003535)3.13117297
31Ketosis (HP:0001946)3.11938642
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.09286584
33Deep venous thrombosis (HP:0002625)3.04818684
34Aplasia/Hypoplasia of the sacrum (HP:0008517)3.03989052
35Hyperlipoproteinemia (HP:0010980)3.03310204
36Increased hepatocellular lipid droplets (HP:0006565)3.01325672
37Increased intramyocellular lipid droplets (HP:0012240)2.97679889
38Increased serum lactate (HP:0002151)2.96884702
39Increased muscle lipid content (HP:0009058)2.96505384
40Hypolipoproteinemia (HP:0010981)2.96314918
41Lactic acidosis (HP:0003128)2.93508681
42Reticulocytopenia (HP:0001896)2.91368422
43Pancreatic cysts (HP:0001737)2.90588239
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.88529194
45Abnormality of midbrain morphology (HP:0002418)2.87512870
46Molar tooth sign on MRI (HP:0002419)2.87512870
47Dicarboxylic aciduria (HP:0003215)2.86406556
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.86406556
49Renal Fanconi syndrome (HP:0001994)2.81584317
50Pancreatic fibrosis (HP:0100732)2.81002355
51Abnormality of fatty-acid metabolism (HP:0004359)2.79359755
52Abnormality of alanine metabolism (HP:0010916)2.78762236
53Hyperalaninemia (HP:0003348)2.78762236
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.78762236
55Medial flaring of the eyebrow (HP:0010747)2.78721497
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77834533
57Optic disc pallor (HP:0000543)2.76266911
58Abnormality of glycolysis (HP:0004366)2.73615621
59Increased serum pyruvate (HP:0003542)2.73615621
60Abnormality of nucleobase metabolism (HP:0010932)2.70165869
61Hypoglycemic coma (HP:0001325)2.68923465
62Epidermoid cyst (HP:0200040)2.67858618
63Macrocytic anemia (HP:0001972)2.67845320
64Abnormality of urine glucose concentration (HP:0011016)2.67037696
65Glycosuria (HP:0003076)2.67037696
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.64103736
67Hyperbilirubinemia (HP:0002904)2.59222677
68Aplastic anemia (HP:0001915)2.58862027
69Methylmalonic aciduria (HP:0012120)2.54299638
70True hermaphroditism (HP:0010459)2.53856544
71Joint hemorrhage (HP:0005261)2.49110900
72Complement deficiency (HP:0004431)2.48791411
73Metabolic acidosis (HP:0001942)2.48141953
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47495063
75Progressive macrocephaly (HP:0004481)2.46340671
76Exertional dyspnea (HP:0002875)2.44539639
77Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43973587
78Ketoacidosis (HP:0001993)2.43161723
79Leukodystrophy (HP:0002415)2.42670251
80Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.41917703
81Fat malabsorption (HP:0002630)2.41386422
82Abnormal rod and cone electroretinograms (HP:0008323)2.38863479
83Conjugated hyperbilirubinemia (HP:0002908)2.38533629
84Hypoalphalipoproteinemia (HP:0003233)2.37603980
85Congenital, generalized hypertrichosis (HP:0004540)2.35610205
86Abnormal hemoglobin (HP:0011902)2.33648622
87Nephronophthisis (HP:0000090)2.29837240
88Delayed CNS myelination (HP:0002188)2.28651217
89CNS demyelination (HP:0007305)2.28450176
90Vomiting (HP:0002013)2.27838024
91Megaloblastic anemia (HP:0001889)2.25242821
92Hyperphosphaturia (HP:0003109)2.23093800
93Abnormality of purine metabolism (HP:0004352)2.20935324
94Amniotic constriction ring (HP:0009775)2.16763117
95Abnormality of placental membranes (HP:0011409)2.16763117
96Respiratory failure (HP:0002878)2.16017851
97Late onset (HP:0003584)2.15505928
98Microvesicular hepatic steatosis (HP:0001414)2.14847818
99Congenital primary aphakia (HP:0007707)2.14315927
100Proximal tubulopathy (HP:0000114)2.12593705
101Gait imbalance (HP:0002141)2.09162438
102Exercise intolerance (HP:0003546)2.09025485
103Hyperinsulinemic hypoglycemia (HP:0000825)2.08879450
104Abnormality of the heme biosynthetic pathway (HP:0010472)2.07348575
105Metaphyseal dysplasia (HP:0100255)2.07051584
106Palpitations (HP:0001962)2.06566175
107Absent/shortened dynein arms (HP:0200106)2.04210155
108Dynein arm defect of respiratory motile cilia (HP:0012255)2.04210155
109Abnormality of complement system (HP:0005339)2.04182259
110Abnormal number of erythroid precursors (HP:0012131)2.03587087
111Hypothermia (HP:0002045)2.02993467
112Hypochromic microcytic anemia (HP:0004840)2.02912495
113Abnormality of vitamin B metabolism (HP:0004340)2.02449097
114Abnormality of cells of the erythroid lineage (HP:0012130)2.02356290
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00596326
116Nausea (HP:0002018)2.00385197
117Respiratory difficulties (HP:0002880)2.00073787
118Nephrogenic diabetes insipidus (HP:0009806)1.99591246
119Opisthotonus (HP:0002179)1.98928177
120Type I transferrin isoform profile (HP:0003642)1.98417961
121Elevated hepatic transaminases (HP:0002910)1.97662391
122Sudden death (HP:0001699)1.97317807
123Abnormality of the renal cortex (HP:0011035)1.94772279
124Progressive external ophthalmoplegia (HP:0000590)1.94587460
125Abnormality of renal resorption (HP:0011038)1.93563615
126Muscle hypertrophy of the lower extremities (HP:0008968)1.92897379
127Prolonged neonatal jaundice (HP:0006579)1.92135578
128Reduced antithrombin III activity (HP:0001976)1.91964343
129Cerebral palsy (HP:0100021)1.90996711
130Renal cortical cysts (HP:0000803)1.90864604
131Abnormality of the vitamin B12 metabolism (HP:0004341)1.89066935
132Type 2 muscle fiber atrophy (HP:0003554)1.87999818
133Abolished electroretinogram (ERG) (HP:0000550)1.86437676
134Constricted visual fields (HP:0001133)1.86252896
135Abnormal respiratory motile cilium physiology (HP:0012261)1.82361170
136X-linked dominant inheritance (HP:0001423)1.80386258
137Abnormal ciliary motility (HP:0012262)1.78279810
138Congenital stationary night blindness (HP:0007642)1.77987858
139Abnormality of the renal medulla (HP:0100957)1.76730038
140Abnormal respiratory motile cilium morphology (HP:0005938)1.76019876
141Abnormal respiratory epithelium morphology (HP:0012253)1.76019876
142Sclerocornea (HP:0000647)1.73635743
143Syncope (HP:0001279)1.69192303
144Male pseudohermaphroditism (HP:0000037)1.69008073
145Abnormal urine phosphate concentration (HP:0012599)1.66979107
146Left ventricular hypertrophy (HP:0001712)1.66860924
147Genital tract atresia (HP:0001827)1.66631073
148Abnormal glycosylation (HP:0012345)1.65037398
149Abnormal protein N-linked glycosylation (HP:0012347)1.65037398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.43628870
2BCKDK3.87759440
3VRK23.39801276
4NME23.36029620
5SRPK13.29906074
6STK163.10848226
7MST42.84628087
8FRK2.73175708
9BUB12.68974027
10NUAK12.67234245
11CDK192.42104139
12EIF2AK12.34790154
13TAF12.22259131
14NEK92.09060955
15BRAF2.01319407
16BMPR1B1.90232365
17TESK21.90056591
18PLK41.87234303
19MAP4K21.86561004
20TAOK31.70115352
21GRK11.55247860
22CASK1.54933652
23IRAK11.54560875
24IRAK41.53936806
25ADRBK21.51822893
26TIE11.41072091
27OXSR11.39202891
28MAP3K121.37903359
29VRK11.35399180
30FLT31.34589639
31TNIK1.25326213
32BRSK21.24939350
33TYK21.24895902
34WEE11.24802601
35PIM21.20297154
36MAP4K11.20092853
37KDR1.19134601
38PNCK1.19015313
39CCNB11.18951138
40PHKG11.18083032
41PHKG21.18083032
42ZAK1.16531895
43MYLK1.14338392
44IRAK31.13723744
45GRK61.11037200
46TRIM281.09881279
47PDK41.06444702
48PDK31.06444702
49TESK11.06248419
50ICK1.03855075
51ACVR1B1.01644768
52FGFR40.98815538
53AURKA0.98247495
54BLK0.97525192
55MST1R0.97349816
56TSSK60.96432205
57MAP3K110.96362382
58MELK0.95472260
59PLK30.92457661
60ERBB30.91419918
61CSNK1G20.90179879
62PRKCE0.89892318
63MAPK130.89696024
64INSRR0.89452168
65EIF2AK30.89396427
66WNK30.89221336
67DAPK30.88439474
68PAK30.88220303
69STK390.87998420
70PLK10.87739268
71ABL20.86714890
72MAP2K60.86544526
73MUSK0.84868651
74WNK40.84291417
75TTK0.84129748
76STK38L0.84041783
77NEK10.83339698
78MAP3K40.82746997
79PIM10.81868974
80PIK3CA0.80826025
81DYRK20.80082345
82DYRK30.79116054
83TXK0.78349873
84EPHA30.77286645
85MAPKAPK30.76977651
86IRAK20.72114063
87STK240.71206634
88NME10.71035286
89KIT0.70522817
90AURKB0.69011484
91GRK50.68904327
92CSNK1G30.68522335
93AKT30.68493615
94OBSCN0.67533877
95PBK0.67079031
96ZAP700.66785038
97MAPK150.66492048
98MKNK20.65614084
99MAP3K50.65440729
100PRKG10.65252607
101CDK70.64830491
102MAP2K20.64730797
103CSNK1G10.64051596
104SCYL20.63219965
105PINK10.62613116
106CAMK2D0.62596692
107LIMK10.61815174
108DAPK10.59543223
109CAMKK20.58188970
110PLK20.58087300
111CSNK2A20.57157182
112CSF1R0.57151503
113PASK0.56295099
114CDC70.55507022
115IKBKE0.55232491
116PRKACA0.55077753
117MKNK10.55066162
118CSNK2A10.54777459
119IKBKB0.54560406
120CAMK2A0.52268950
121BTK0.52053814
122PIK3CG0.51939186
123PRKCG0.51160545
124NEK20.51160412
125DMPK0.51098797
126TEC0.50854809
127MAP3K100.50759886
128MAPK40.50147308
129NLK0.50004966
130CHEK20.49702965
131MAP3K140.49585551
132CLK10.49527134
133CSK0.48757741
134ADRBK10.48048583
135ATR0.47449341
136ROCK10.47304656
137ILK0.46730416
138CSNK1A1L0.46693405
139MAPK110.46237746
140LYN0.45888484
141CDK80.45804395
142BRSK10.43793193
143EIF2AK20.42254192
144ERBB40.41970533
145PRKCQ0.40955513
146CAMK10.40121023
147JAK10.39987159
148CDK40.39335402
149RPS6KA50.39026925
150ARAF0.38872179
151ITK0.37331731
152PRKCA0.36322958
153GRK70.36285771
154MAP2K70.35985375
155CSNK1A10.33720992
156TRPM70.32087506

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.14204968
2Cardiac muscle contraction_Homo sapiens_hsa042602.82490556
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66429695
4Ribosome_Homo sapiens_hsa030102.52105982
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.47874268
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39532565
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22007367
8Sulfur relay system_Homo sapiens_hsa041222.16329146
9Tryptophan metabolism_Homo sapiens_hsa003802.12142709
10Fatty acid degradation_Homo sapiens_hsa000712.11688481
11Propanoate metabolism_Homo sapiens_hsa006402.01823238
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96535440
13Folate biosynthesis_Homo sapiens_hsa007901.93483772
14Proteasome_Homo sapiens_hsa030501.87891836
15Peroxisome_Homo sapiens_hsa041461.84484926
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82114201
17Oxidative phosphorylation_Homo sapiens_hsa001901.81369422
18Protein export_Homo sapiens_hsa030601.77549679
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76844125
20Sulfur metabolism_Homo sapiens_hsa009201.76664101
21Pyruvate metabolism_Homo sapiens_hsa006201.76449206
22RNA polymerase_Homo sapiens_hsa030201.76341650
23Butanoate metabolism_Homo sapiens_hsa006501.74835451
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72846820
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.72115655
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70201118
27DNA replication_Homo sapiens_hsa030301.66850469
28Arginine biosynthesis_Homo sapiens_hsa002201.64822472
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.60162849
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59938720
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57305281
32Vitamin B6 metabolism_Homo sapiens_hsa007501.56921000
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56620301
34beta-Alanine metabolism_Homo sapiens_hsa004101.56190524
35Parkinsons disease_Homo sapiens_hsa050121.54194986
36Regulation of autophagy_Homo sapiens_hsa041401.52985881
37Phototransduction_Homo sapiens_hsa047441.44349091
38Complement and coagulation cascades_Homo sapiens_hsa046101.44084994
39Pyrimidine metabolism_Homo sapiens_hsa002401.43049385
40Carbon metabolism_Homo sapiens_hsa012001.42437461
41One carbon pool by folate_Homo sapiens_hsa006701.40320376
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40236699
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.37865913
44Histidine metabolism_Homo sapiens_hsa003401.33849336
45Chemical carcinogenesis_Homo sapiens_hsa052041.33471803
46Homologous recombination_Homo sapiens_hsa034401.30666459
47Retinol metabolism_Homo sapiens_hsa008301.29448961
48Asthma_Homo sapiens_hsa053101.29246851
49Biosynthesis of amino acids_Homo sapiens_hsa012301.26552457
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24726492
51Selenocompound metabolism_Homo sapiens_hsa004501.23384124
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.22433426
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.21214965
54Mismatch repair_Homo sapiens_hsa034301.20488403
55Fatty acid metabolism_Homo sapiens_hsa012121.18417050
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13972126
57Type I diabetes mellitus_Homo sapiens_hsa049401.12543786
58Fatty acid elongation_Homo sapiens_hsa000621.12269632
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10600029
60PPAR signaling pathway_Homo sapiens_hsa033201.05685441
61Pentose phosphate pathway_Homo sapiens_hsa000301.03695120
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03055394
63Base excision repair_Homo sapiens_hsa034101.02949866
64Huntingtons disease_Homo sapiens_hsa050161.02559569
65Alzheimers disease_Homo sapiens_hsa050101.01226327
66Collecting duct acid secretion_Homo sapiens_hsa049660.99521432
67Arginine and proline metabolism_Homo sapiens_hsa003300.98141489
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96419891
69Glutathione metabolism_Homo sapiens_hsa004800.95108521
70Steroid biosynthesis_Homo sapiens_hsa001000.92608091
71Nucleotide excision repair_Homo sapiens_hsa034200.92220720
72Staphylococcus aureus infection_Homo sapiens_hsa051500.91477280
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90452261
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89623015
75Tyrosine metabolism_Homo sapiens_hsa003500.88797127
76Allograft rejection_Homo sapiens_hsa053300.88213604
77Phenylalanine metabolism_Homo sapiens_hsa003600.87379309
78Metabolic pathways_Homo sapiens_hsa011000.86786761
79Fanconi anemia pathway_Homo sapiens_hsa034600.85271334
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85153474
81Spliceosome_Homo sapiens_hsa030400.85016126
82Vitamin digestion and absorption_Homo sapiens_hsa049770.84948618
83Starch and sucrose metabolism_Homo sapiens_hsa005000.83081039
84Caffeine metabolism_Homo sapiens_hsa002320.81870786
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.80860349
86Fat digestion and absorption_Homo sapiens_hsa049750.75881936
87Graft-versus-host disease_Homo sapiens_hsa053320.74889500
88Autoimmune thyroid disease_Homo sapiens_hsa053200.74193848
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68866492
90Purine metabolism_Homo sapiens_hsa002300.66461578
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61775680
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61739280
93RNA degradation_Homo sapiens_hsa030180.60594608
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60437886
95Rheumatoid arthritis_Homo sapiens_hsa053230.55327942
96Olfactory transduction_Homo sapiens_hsa047400.53024244
97Fructose and mannose metabolism_Homo sapiens_hsa000510.51981718
98Ether lipid metabolism_Homo sapiens_hsa005650.51662940
99ABC transporters_Homo sapiens_hsa020100.49923141
100Nitrogen metabolism_Homo sapiens_hsa009100.49649356
101Systemic lupus erythematosus_Homo sapiens_hsa053220.49171783
102Mineral absorption_Homo sapiens_hsa049780.48529507
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47437359
104RNA transport_Homo sapiens_hsa030130.46503277
105Galactose metabolism_Homo sapiens_hsa000520.45336191
106Non-homologous end-joining_Homo sapiens_hsa034500.44445035
107Linoleic acid metabolism_Homo sapiens_hsa005910.44435735
108Other glycan degradation_Homo sapiens_hsa005110.42170688
109Nicotine addiction_Homo sapiens_hsa050330.40450909
110Glycerolipid metabolism_Homo sapiens_hsa005610.40310937
111Bile secretion_Homo sapiens_hsa049760.39636187
112Lysine degradation_Homo sapiens_hsa003100.38653691
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37462604
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35231096
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34400124
116Antigen processing and presentation_Homo sapiens_hsa046120.34288149
117Serotonergic synapse_Homo sapiens_hsa047260.34253294
118Circadian rhythm_Homo sapiens_hsa047100.34049359
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33866728
120Basal transcription factors_Homo sapiens_hsa030220.32602897
121Arachidonic acid metabolism_Homo sapiens_hsa005900.31367496
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29524512
123Insulin secretion_Homo sapiens_hsa049110.28688319
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26107883
125Pancreatic secretion_Homo sapiens_hsa049720.23619927
126Primary immunodeficiency_Homo sapiens_hsa053400.21980252

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