MTM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.44956573
2neutrophil activation involved in immune response (GO:0002283)4.95406860
3positive regulation of cellular amide metabolic process (GO:0034250)4.80999986
4cellular extravasation (GO:0045123)4.37124141
5superoxide anion generation (GO:0042554)4.36871074
6positive regulation by symbiont of host defense response (GO:0052509)4.27662120
7modulation by symbiont of host defense response (GO:0052031)4.27662120
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.27662120
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.27662120
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.27662120
11modulation by symbiont of host immune response (GO:0052553)4.27662120
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17141442
13negative regulation of cell killing (GO:0031342)4.17141442
14response to peptidoglycan (GO:0032494)4.00383179
15central nervous system myelination (GO:0022010)3.87524227
16axon ensheathment in central nervous system (GO:0032291)3.87524227
17regulation of gamma-delta T cell differentiation (GO:0045586)3.85672358
18regulation of gamma-delta T cell activation (GO:0046643)3.85430409
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81538228
20neutrophil activation (GO:0042119)3.69378082
21respiratory burst (GO:0045730)3.69275041
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.68923241
23detection of other organism (GO:0098543)3.56804244
24leukocyte degranulation (GO:0043299)3.51514934
25granulocyte activation (GO:0036230)3.47309739
26positive regulation of granulocyte differentiation (GO:0030854)3.45061782
27natural killer cell activation involved in immune response (GO:0002323)3.36517650
28microglial cell activation (GO:0001774)3.32981316
29regulation of B cell receptor signaling pathway (GO:0050855)3.28856699
30detection of bacterium (GO:0016045)3.21665737
31positive regulation of B cell differentiation (GO:0045579)3.18841848
32regulation of regulatory T cell differentiation (GO:0045589)3.17295543
33regulation of dendritic cell antigen processing and presentation (GO:0002604)3.16464539
34T-helper 1 type immune response (GO:0042088)3.15692371
35detection of molecule of bacterial origin (GO:0032490)3.14879184
36response to host immune response (GO:0052572)3.13011106
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.13011106
38response to interleukin-15 (GO:0070672)3.12230227
39hydrogen peroxide biosynthetic process (GO:0050665)3.11481058
40macrophage activation involved in immune response (GO:0002281)3.10396576
41B cell receptor signaling pathway (GO:0050853)3.10017775
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09987755
43positive regulation of toll-like receptor signaling pathway (GO:0034123)3.05367093
44positive regulation of heat generation (GO:0031652)3.03778223
45hepatocyte apoptotic process (GO:0097284)3.01752493
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.00552527
47positive regulation of antigen processing and presentation (GO:0002579)3.00203230
48positive regulation of monocyte chemotaxis (GO:0090026)3.00184823
49long-chain fatty acid biosynthetic process (GO:0042759)2.99443344
50sphingosine metabolic process (GO:0006670)2.99131178
51detection of external biotic stimulus (GO:0098581)2.97133837
52regulation of heat generation (GO:0031650)2.93424640
53leukocyte migration involved in inflammatory response (GO:0002523)2.92062533
54regulation of activation of Janus kinase activity (GO:0010533)2.91431820
55positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.90815832
56positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.90484600
57reactive oxygen species biosynthetic process (GO:1903409)2.88447962
58regulation of interferon-beta biosynthetic process (GO:0045357)2.88314359
59negative thymic T cell selection (GO:0045060)2.87673074
60antigen processing and presentation of endogenous antigen (GO:0019883)2.87504743
61cellular response to interleukin-15 (GO:0071350)2.83545033
62embryonic process involved in female pregnancy (GO:0060136)2.82163058
63positive regulation of tolerance induction (GO:0002645)2.81167055
64G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.80350409
65macrophage activation (GO:0042116)2.80194476
66B cell mediated immunity (GO:0019724)2.80140547
67diol metabolic process (GO:0034311)2.79833289
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79678912
69regulation of fever generation (GO:0031620)2.79321245
70regulation of tolerance induction (GO:0002643)2.77882629
71fatty acid elongation (GO:0030497)2.77751136
72sphingoid metabolic process (GO:0046519)2.76895780
73negative T cell selection (GO:0043383)2.76510764
74negative regulation of T cell mediated immunity (GO:0002710)2.76442587
75phagosome maturation (GO:0090382)2.75935728
76production of molecular mediator involved in inflammatory response (GO:0002532)2.75763753
77negative regulation of interleukin-12 production (GO:0032695)2.75579202
78growth hormone receptor signaling pathway (GO:0060396)2.75400882
79regulation of B cell differentiation (GO:0045577)2.75276617
80tolerance induction (GO:0002507)2.74217439
81neutrophil mediated immunity (GO:0002446)2.73050961
82positive regulation of interferon-alpha production (GO:0032727)2.72219354
83regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72003187
84response to muramyl dipeptide (GO:0032495)2.69599557
85superoxide metabolic process (GO:0006801)2.69496221
86myeloid cell activation involved in immune response (GO:0002275)2.63421538
87lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62616869
88L-amino acid import (GO:0043092)2.62433066
89regulation of alpha-beta T cell proliferation (GO:0046640)2.61821454
90response to lipoprotein particle (GO:0055094)2.61545088
91regulation of RIG-I signaling pathway (GO:0039535)2.61502541
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.60771981
93Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60400265
94positive regulation of alpha-beta T cell proliferation (GO:0046641)2.59917989
95negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.59430232
96import into cell (GO:0098657)2.59359195
97negative regulation of mast cell activation (GO:0033004)2.58576143
98regulation of antigen processing and presentation (GO:0002577)2.58099779
99regulation of interferon-alpha production (GO:0032647)2.57709976
100natural killer cell differentiation (GO:0001779)2.56966636
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.56927185
102nucleotide transmembrane transport (GO:1901679)2.56838211
103negative regulation of T-helper cell differentiation (GO:0045623)2.56058817
104negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.56058817
105regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.54031775
106regulation of necroptotic process (GO:0060544)2.53331193
107negative regulation of adaptive immune response (GO:0002820)2.51423387
108regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.50618808
109positive regulation of interleukin-1 beta secretion (GO:0050718)2.50298365
110intracellular pH reduction (GO:0051452)2.50099958
111dendritic cell migration (GO:0036336)2.49968727
112regulation of mast cell degranulation (GO:0043304)2.49503195
113regulation of T cell tolerance induction (GO:0002664)2.49273845
114histamine secretion (GO:0001821)2.48946064
115detection of biotic stimulus (GO:0009595)2.47783814
116cellular response to growth hormone stimulus (GO:0071378)2.46828651
117T cell selection (GO:0045058)2.45935306
118organelle membrane fusion (GO:0090174)2.44501289
119positive regulation of leukocyte degranulation (GO:0043302)2.44431768
120positive regulation of acute inflammatory response (GO:0002675)2.44385777
121antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.44160999
122regulation of mast cell activation (GO:0033003)2.43873650
123regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.43734410
124positive regulation of mast cell degranulation (GO:0043306)2.43290867
125positive regulation of mast cell activation involved in immune response (GO:0033008)2.43290867
126eosinophil chemotaxis (GO:0048245)2.42917773
127positive regulation of humoral immune response (GO:0002922)2.42730318
128negative regulation of lipid storage (GO:0010888)2.42702105
129response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.42621036
130response to host (GO:0075136)2.42621036
131response to host defenses (GO:0052200)2.42621036
132positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42270122
133negative regulation of B cell mediated immunity (GO:0002713)2.41265394
134negative regulation of immunoglobulin mediated immune response (GO:0002890)2.41265394
135negative regulation of leukocyte mediated immunity (GO:0002704)2.40917027
136regulation of germinal center formation (GO:0002634)2.40444374
137negative regulation of interleukin-17 production (GO:0032700)2.40337067
138positive regulation of oligodendrocyte differentiation (GO:0048714)2.36801808
139regulation of interleukin-1 beta secretion (GO:0050706)2.36724926
140positive regulation of interleukin-17 production (GO:0032740)2.34039659
141regulation of platelet aggregation (GO:0090330)2.34004387
142positive regulation of interleukin-1 secretion (GO:0050716)2.33934293
143positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.33233912
144regulation of mast cell activation involved in immune response (GO:0033006)2.32879826
145dendritic cell chemotaxis (GO:0002407)2.31800697
146regulation of interleukin-17 production (GO:0032660)2.31445746
147positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.30234105
148modulation of growth of symbiont involved in interaction with host (GO:0044144)2.28572672
149regulation of growth of symbiont in host (GO:0044126)2.28572672
150negative regulation of growth of symbiont in host (GO:0044130)2.28572672
151negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.28572672
152immunoglobulin mediated immune response (GO:0016064)2.28157644
153defense response to protozoan (GO:0042832)2.27698759
154leukocyte aggregation (GO:0070486)2.27380905
155positive regulation of type 2 immune response (GO:0002830)2.26647984
156positive regulation of mast cell activation (GO:0033005)2.26193605
157amyloid precursor protein catabolic process (GO:0042987)2.25344238
158regulation of interleukin-8 biosynthetic process (GO:0045414)2.24615202
159positive regulation of T cell migration (GO:2000406)2.24547773
160glycerophospholipid catabolic process (GO:0046475)2.22806713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.56100152
2* IRF8_21731497_ChIP-ChIP_J774_Mouse3.54344700
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.51615549
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14037975
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.84644729
6* IRF8_27001747_Chip-Seq_BMDM_Mouse2.51821605
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42977630
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41289384
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37979996
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22026243
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22003110
12GBX2_23144817_ChIP-Seq_PC3_Human2.18525167
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18464924
14* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11952116
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10320227
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.06123845
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.04929593
18MYB_26560356_Chip-Seq_TH2_Human2.04629650
19SPI1_23547873_ChIP-Seq_NB4_Human2.03621818
20* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02374071
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.95837795
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.93745080
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91619385
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.91578484
25SCL_19346495_ChIP-Seq_HPC-7_Human1.90632463
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81768651
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.80517654
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.78057913
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77801959
30SPI1_23127762_ChIP-Seq_K562_Human1.75884142
31* MYB_26560356_Chip-Seq_TH1_Human1.71328450
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71029029
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70255361
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65177388
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63923683
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63665774
37* GATA3_26560356_Chip-Seq_TH2_Human1.62465569
38SUZ12_18555785_Chip-Seq_ESCs_Mouse1.62398862
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58395365
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57617625
41STAT3_18555785_Chip-Seq_ESCs_Mouse1.56665635
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53225258
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.52871039
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52197400
45P53_22387025_ChIP-Seq_ESCs_Mouse1.52148304
46E2F1_18555785_Chip-Seq_ESCs_Mouse1.51930843
47CMYC_18555785_Chip-Seq_ESCs_Mouse1.51180102
48TAF15_26573619_Chip-Seq_HEK293_Human1.50392197
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49653448
50ER_23166858_ChIP-Seq_MCF-7_Human1.49261259
51* GATA3_27048872_Chip-Seq_THYMUS_Human1.46305232
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.46255022
53P300_18555785_Chip-Seq_ESCs_Mouse1.45892260
54RUNX1_27457419_Chip-Seq_LIVER_Mouse1.45843853
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.45316119
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44205352
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44205352
58VDR_24787735_ChIP-Seq_THP-1_Human1.41451917
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38943519
60PU1_27457419_Chip-Seq_LIVER_Mouse1.38117000
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37530405
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.37029216
63VDR_22108803_ChIP-Seq_LS180_Human1.36901867
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36237879
65NMYC_18555785_Chip-Seq_ESCs_Mouse1.35937150
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.35058185
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.33979914
68P300_19829295_ChIP-Seq_ESCs_Human1.32685761
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32176642
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32148464
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.31374452
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.31241847
73SMAD1_18555785_Chip-Seq_ESCs_Mouse1.31143560
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30927302
75OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27511946
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27240181
77KLF4_18555785_Chip-Seq_ESCs_Mouse1.27108072
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.26167997
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26069999
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25624445
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25543655
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25201865
83ZFX_18555785_Chip-Seq_ESCs_Mouse1.25025895
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24194420
85* TFEB_21752829_ChIP-Seq_HELA_Human1.23438915
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.23108139
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22992056
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22210304
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21928720
90ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21756481
91CTCF_18555785_Chip-Seq_ESCs_Mouse1.18938019
92* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16187039
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15889910
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13413963
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13272672
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.12971974
97TP53_18474530_ChIP-ChIP_U2OS_Human1.12128380
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12015300
99SALL4_22934838_ChIP-ChIP_CD34+_Human1.10604383
100* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09978299
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09914606
102GATA1_22025678_ChIP-Seq_K562_Human1.09490048
103VDR_24763502_ChIP-Seq_THP-1_Human1.09096331
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08523508
105HTT_18923047_ChIP-ChIP_STHdh_Human1.08324099
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08195111
107GATA2_21666600_ChIP-Seq_HMVEC_Human1.07948505
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07873775
109CDX2_22108803_ChIP-Seq_LS180_Human1.07119320
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06887483
111MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05401488
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04479055
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03913862
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03748247
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03416263
116LXR_22158963_ChIP-Seq_LIVER_Mouse1.03173192
117SMAD4_21799915_ChIP-Seq_A2780_Human1.02638330
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00600932
119GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00322268
120SOX2_20726797_ChIP-Seq_SW620_Human0.99801315
121SMRT_27268052_Chip-Seq_Bcells_Human0.95345710
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95145521
123* CJUN_26792858_Chip-Seq_BT549_Human0.94967522
124* KDM2B_26808549_Chip-Seq_REH_Human0.94860686
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94530831
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.94442385
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94334964
128TP53_16413492_ChIP-PET_HCT116_Human0.94246757
129FUS_26573619_Chip-Seq_HEK293_Human0.93876028
130PU_27001747_Chip-Seq_BMDM_Mouse0.93715903
131FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93706173
132ELK1_19687146_ChIP-ChIP_HELA_Human0.91648092
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91559861
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91312261
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91143420
136CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91111818
137TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91070421
138TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90928987
139PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90422440
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90093638
141AHR_22903824_ChIP-Seq_MCF-7_Human0.89657448
142CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88897668
143RUNX_20019798_ChIP-Seq_JUKART_Human0.88385167
144FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87301885
145VDR_23849224_ChIP-Seq_CD4+_Human0.87248746
146GATA2_19941826_ChIP-Seq_K562_Human0.87187378
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87080986
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86901988
149KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86525433
150NOTCH1_21737748_ChIP-Seq_TLL_Human0.86062192
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.85378870
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85252642
153* RUNX2_22187159_ChIP-Seq_PCA_Human0.85072839
154HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83990011
155CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81696305
156RXR_22158963_ChIP-Seq_LIVER_Mouse0.81373227
157NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80922119
158TP63_23658742_ChIP-Seq_EP156T_Human0.79196581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.61810160
2MP0001835_abnormal_antigen_presentation3.15345927
3MP0009785_altered_susceptibility_to3.02441808
4MP0002148_abnormal_hypersensitivity_rea2.89178381
5MP0002419_abnormal_innate_immunity2.86295234
6MP0003436_decreased_susceptibility_to2.55989124
7MP0005058_abnormal_lysosome_morphology2.55244829
8MP0003690_abnormal_glial_cell2.41850375
9MP0000920_abnormal_myelination2.36251528
10MP0005025_abnormal_response_to2.34808992
11MP0003136_yellow_coat_color2.34741085
12MP0006082_CNS_inflammation2.30433187
13MP0002277_abnormal_respiratory_mucosa2.29689458
14MP0004381_abnormal_hair_follicle2.21752216
15MP0001790_abnormal_immune_system2.21080182
16MP0005387_immune_system_phenotype2.21080182
17MP0005000_abnormal_immune_tolerance2.20920287
18MP0000465_gastrointestinal_hemorrhage2.19366956
19MP0003763_abnormal_thymus_physiology2.17547610
20MP0006054_spinal_hemorrhage2.14455541
21MP0004782_abnormal_surfactant_physiolog2.13036007
22MP0003191_abnormal_cellular_cholesterol2.11305720
23MP0002396_abnormal_hematopoietic_system2.03978008
24MP0003806_abnormal_nucleotide_metabolis2.03439485
25MP0003656_abnormal_erythrocyte_physiolo2.02480993
26MP0003950_abnormal_plasma_membrane1.90300058
27MP0008057_abnormal_DNA_replication1.87998640
28MP0009764_decreased_sensitivity_to1.78684569
29MP0002452_abnormal_antigen_presenting1.76342134
30MP0002723_abnormal_immune_serum1.75458849
31MP0009840_abnormal_foam_cell1.67093680
32MP0000569_abnormal_digit_pigmentation1.65002698
33MP0001800_abnormal_humoral_immune1.62550615
34MP0005174_abnormal_tail_pigmentation1.60944935
35MP0008260_abnormal_autophagy1.60858295
36MP0005171_absent_coat_pigmentation1.59905907
37MP0001533_abnormal_skeleton_physiology1.58092528
38MP0000015_abnormal_ear_pigmentation1.56929931
39MP0002398_abnormal_bone_marrow1.56908804
40MP0005451_abnormal_body_composition1.54168293
41MP0003300_gastrointestinal_ulcer1.54114864
42MP0005671_abnormal_response_to1.48273801
43MP0003172_abnormal_lysosome_physiology1.47368815
44MP0009333_abnormal_splenocyte_physiolog1.46942616
45MP0003195_calcinosis1.43595361
46MP0000383_abnormal_hair_follicle1.42270882
47MP0001819_abnormal_immune_cell1.39172393
48MP0000689_abnormal_spleen_morphology1.38675928
49MP0005310_abnormal_salivary_gland1.37055828
50MP0002420_abnormal_adaptive_immunity1.37006275
51MP0001188_hyperpigmentation1.36977781
52MP0008469_abnormal_protein_level1.36643417
53MP0004742_abnormal_vestibular_system1.33219049
54MP0002139_abnormal_hepatobiliary_system1.31492081
55MP0001845_abnormal_inflammatory_respons1.31473268
56MP0002722_abnormal_immune_system1.30554305
57MP0002138_abnormal_hepatobiliary_system1.28497118
58MP0005464_abnormal_platelet_physiology1.27719983
59MP0000685_abnormal_immune_system1.27386177
60MP0005085_abnormal_gallbladder_physiolo1.25214304
61MP0002006_tumorigenesis1.24076113
62MP0005379_endocrine/exocrine_gland_phen1.23101664
63MP0002998_abnormal_bone_remodeling1.23061367
64MP0004883_abnormal_blood_vessel1.22881272
65MP0000703_abnormal_thymus_morphology1.22778984
66MP0002429_abnormal_blood_cell1.19731906
67MP0000343_altered_response_to1.19566286
68MP0004019_abnormal_vitamin_homeostasis1.18291678
69MP0003866_abnormal_defecation1.17942635
70MP0010155_abnormal_intestine_physiology1.17236279
71MP0001545_abnormal_hematopoietic_system1.16317160
72MP0005397_hematopoietic_system_phenotyp1.16317160
73MP0005360_urolithiasis1.14934214
74MP0001346_abnormal_lacrimal_gland1.14313770
75MP0001666_abnormal_nutrient_absorption1.13870378
76MP0004142_abnormal_muscle_tone1.12594672
77MP0000566_synostosis1.10168067
78MP0002405_respiratory_system_inflammati1.07703033
79MP0002009_preneoplasia1.06743667
80MP0005319_abnormal_enzyme/_coenzyme1.06640845
81MP0003075_altered_response_to1.03836287
82MP0009763_increased_sensitivity_to1.03553677
83MP0001853_heart_inflammation1.01535839
84MP0005365_abnormal_bile_salt1.01473723
85MP0003186_abnormal_redox_activity1.00892664
86MP0000604_amyloidosis1.00473197
87MP0003303_peritoneal_inflammation0.99980345
88MP0004947_skin_inflammation0.99853413
89MP0005164_abnormal_response_to0.99582902
90MP0003448_altered_tumor_morphology0.98944111
91MP0000858_altered_metastatic_potential0.97349947
92MP0003011_delayed_dark_adaptation0.96713871
93MP0005409_darkened_coat_color0.96588665
94MP0010234_abnormal_vibrissa_follicle0.94402616
95MP0008004_abnormal_stomach_pH0.94104842
96MP0003183_abnormal_peptide_metabolism0.93579199
97MP0005167_abnormal_blood-brain_barrier0.92183311
98MP0002166_altered_tumor_susceptibility0.92151036
99MP0010329_abnormal_lipoprotein_level0.92148182
100MP0009697_abnormal_copulation0.92136202
101MP0004510_myositis0.90623673
102MP0001851_eye_inflammation0.90093730
103MP0000249_abnormal_blood_vessel0.89374027
104MP0008875_abnormal_xenobiotic_pharmacok0.89110964
105MP0010386_abnormal_urinary_bladder0.86441773
106MP0003828_pulmonary_edema0.86339360
107MP0010678_abnormal_skin_adnexa0.86237418
108MP0001764_abnormal_homeostasis0.84503050
109MP0002118_abnormal_lipid_homeostasis0.84247739
110MP0004808_abnormal_hematopoietic_stem0.83424538
111MP0005390_skeleton_phenotype0.81289260
112MP0001986_abnormal_taste_sensitivity0.80893068
113MP0002132_abnormal_respiratory_system0.80148221
114MP0005645_abnormal_hypothalamus_physiol0.79529158
115MP0005376_homeostasis/metabolism_phenot0.78719319
116MP0003252_abnormal_bile_duct0.78446392
117MP0002254_reproductive_system_inflammat0.77574135
118MP0003941_abnormal_skin_development0.77532356
119MP0003221_abnormal_cardiomyocyte_apopto0.76382267
120MP0005075_abnormal_melanosome_morpholog0.76266050
121MP0005647_abnormal_sex_gland0.74939237
122MP0001958_emphysema0.74479924
123MP0000716_abnormal_immune_system0.74298869
124MP0002638_abnormal_pupillary_reflex0.74000062
125MP0006036_abnormal_mitochondrial_physio0.73917789
126MP0005584_abnormal_enzyme/coenzyme_acti0.73815306
127MP0003453_abnormal_keratinocyte_physiol0.72920582
128MP0000609_abnormal_liver_physiology0.72388027
129MP0010352_gastrointestinal_tract_polyps0.71850287
130MP0005408_hypopigmentation0.71645254
131MP0005166_decreased_susceptibility_to0.71058612
132MP0000372_irregular_coat_pigmentation0.69603985
133MP0001727_abnormal_embryo_implantation0.66218648
134MP0002019_abnormal_tumor_incidence0.64367677

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.87962220
2Recurrent bacterial skin infections (HP:0005406)5.42156322
3Eczematoid dermatitis (HP:0000976)4.47445341
4Recurrent gram-negative bacterial infections (HP:0005420)4.47444880
5Parakeratosis (HP:0001036)4.30625277
6Abnormality of macrophages (HP:0004311)4.27789502
7Gingivitis (HP:0000230)3.77007409
8Stomatitis (HP:0010280)3.70694757
9Systemic lupus erythematosus (HP:0002725)3.51991291
10Papillary thyroid carcinoma (HP:0002895)3.51282305
11Vacuolated lymphocytes (HP:0001922)3.47932693
12Recurrent skin infections (HP:0001581)3.47115063
13Prostate neoplasm (HP:0100787)3.43148106
14T lymphocytopenia (HP:0005403)3.31165072
15Thick nail (HP:0001805)3.26024989
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15256982
17Abnormality of T cell number (HP:0011839)3.04020530
18Glomerulonephritis (HP:0000099)3.00327817
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.96805877
20Chronic obstructive pulmonary disease (HP:0006510)2.96010556
21Obstructive lung disease (HP:0006536)2.96010556
22Duplicated collecting system (HP:0000081)2.91131391
23Axonal loss (HP:0003447)2.90383417
24Prolonged bleeding time (HP:0003010)2.88448538
25Joint hemorrhage (HP:0005261)2.87979653
26Mediastinal lymphadenopathy (HP:0100721)2.87560779
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.82509377
28Optic neuritis (HP:0100653)2.78641178
29Retrobulbar optic neuritis (HP:0100654)2.78641178
30Disinhibition (HP:0000734)2.66852300
31Congenital ichthyosiform erythroderma (HP:0007431)2.65991963
32Chromsome breakage (HP:0040012)2.63381439
33Encephalitis (HP:0002383)2.62766078
34Hepatosplenomegaly (HP:0001433)2.62041321
35Recurrent pneumonia (HP:0006532)2.61844122
36Loss of speech (HP:0002371)2.60510658
37Orchitis (HP:0100796)2.55218288
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.50888383
39Epistaxis (HP:0000421)2.50447161
40Metaphyseal dysplasia (HP:0100255)2.48779192
41Albinism (HP:0001022)2.46492237
42Prolonged neonatal jaundice (HP:0006579)2.42365742
43Periodontitis (HP:0000704)2.41859714
44Fair hair (HP:0002286)2.39741372
45Congenital sensorineural hearing impairment (HP:0008527)2.37745425
46Keratoconjunctivitis (HP:0001096)2.37386051
47Premature loss of primary teeth (HP:0006323)2.37031712
48Hypophosphatemic rickets (HP:0004912)2.36771534
49Prolonged partial thromboplastin time (HP:0003645)2.36630899
50Spontaneous hematomas (HP:0007420)2.36124780
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.34389186
52Abnormality of the renal collecting system (HP:0004742)2.33330197
53Conjugated hyperbilirubinemia (HP:0002908)2.32566289
54Pustule (HP:0200039)2.32378850
55Vasculitis (HP:0002633)2.31415979
56Abnormality of T cells (HP:0002843)2.28650396
57Thyroid carcinoma (HP:0002890)2.28644216
58Vascular calcification (HP:0004934)2.28362476
59Abnormality of the common coagulation pathway (HP:0010990)2.28064969
60Myositis (HP:0100614)2.27610982
61Recurrent fungal infections (HP:0002841)2.24946157
62Degeneration of anterior horn cells (HP:0002398)2.22084537
63Abnormality of the anterior horn cell (HP:0006802)2.22084537
64Amyloidosis (HP:0011034)2.21308019
65Patchy hypopigmentation of hair (HP:0011365)2.18962830
66Anhidrosis (HP:0000970)2.18846129
67Autoimmune thrombocytopenia (HP:0001973)2.18517883
68Autoimmune hemolytic anemia (HP:0001890)2.18060284
69Neurofibrillary tangles (HP:0002185)2.18044222
70Recurrent viral infections (HP:0004429)2.17890209
71Increased cerebral lipofuscin (HP:0011813)2.17854122
72White forelock (HP:0002211)2.17250838
73IgM deficiency (HP:0002850)2.15410020
74Termporal pattern (HP:0011008)2.14654581
75Insidious onset (HP:0003587)2.14654581
76Gingival bleeding (HP:0000225)2.13908804
77Abnormality of the vasculature of the conjunctiva (HP:0008054)2.13090217
78Myocardial infarction (HP:0001658)2.13010180
79Xerostomia (HP:0000217)2.11893962
80Elevated erythrocyte sedimentation rate (HP:0003565)2.11633595
81Erythroderma (HP:0001019)2.10521605
82Petechiae (HP:0000967)2.09249166
83B lymphocytopenia (HP:0010976)2.07939370
84Abnormality of B cell number (HP:0010975)2.07508176
85Renal cortical cysts (HP:0000803)2.05686795
86Peripheral demyelination (HP:0011096)2.05111325
87Panhypogammaglobulinemia (HP:0003139)2.04804313
88Scanning speech (HP:0002168)2.04189199
89Generalized hypopigmentation of hair (HP:0011358)2.00741242
90Granulocytopenia (HP:0001913)2.00594673
91Bone pain (HP:0002653)2.00477942
92Arterial thrombosis (HP:0004420)1.98642245
93Stomach cancer (HP:0012126)1.98555697
94Aplasia cutis congenita (HP:0001057)1.98291434
95Urticaria (HP:0001025)1.98119419
96Pulmonary embolism (HP:0002204)1.98077823
97Atrophy/Degeneration involving motor neurons (HP:0007373)1.98061113
98Inflammation of the large intestine (HP:0002037)1.97852693
99Lower limb hyperreflexia (HP:0002395)1.97512132
100Nephritis (HP:0000123)1.96676103
101Gastrointestinal infarctions (HP:0005244)1.96663275
102Abnormality of glycolipid metabolism (HP:0010969)1.95288226
103Abnormality of liposaccharide metabolism (HP:0010968)1.95288226
104Abnormality of glycosphingolipid metabolism (HP:0004343)1.95288226
105Cardiovascular calcification (HP:0011915)1.95234100
106Joint swelling (HP:0001386)1.94449295
107Gangrene (HP:0100758)1.94284859
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93988807
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.93988807
110Osteomyelitis (HP:0002754)1.93508437
111Polyneuropathy (HP:0001271)1.91882993
112Mitral stenosis (HP:0001718)1.91403766
113Recurrent bronchitis (HP:0002837)1.90277119
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.89851258
115Acute hepatic failure (HP:0006554)1.89306560
116Cone-rod dystrophy (HP:0000548)1.89029706
117Viral hepatitis (HP:0006562)1.88823511
118Abnormality of iron homeostasis (HP:0011031)1.88770713
119Amyotrophic lateral sclerosis (HP:0007354)1.88678813
120Leukocytosis (HP:0001974)1.88306707
121Acute myeloid leukemia (HP:0004808)1.88014916
122Onion bulb formation (HP:0003383)1.87881846
123Reduced antithrombin III activity (HP:0001976)1.87866175
124Episodic fever (HP:0001954)1.87759846
125Abnormal biliary tract physiology (HP:0012439)1.86665723
126Bile duct proliferation (HP:0001408)1.86665723
127Cheilitis (HP:0100825)1.86602512
128Sensory axonal neuropathy (HP:0003390)1.86575063
129Chest pain (HP:0100749)1.86460133
130Complement deficiency (HP:0004431)1.85147918
131Gastrointestinal inflammation (HP:0004386)1.84742893
132Abnormal spermatogenesis (HP:0008669)1.84605584
133Progressive visual loss (HP:0000529)1.83894743
134Chronic mucocutaneous candidiasis (HP:0002728)1.83860676
135Recurrent cutaneous fungal infections (HP:0011370)1.83860676
136Tubulointerstitial nephritis (HP:0001970)1.82988523
137Eosinophilia (HP:0001880)1.82865104
138Abnormality of the prostate (HP:0008775)1.81766053
139Hyporeflexia of lower limbs (HP:0002600)1.81485113
140Intrahepatic cholestasis (HP:0001406)1.80978668
141IgG deficiency (HP:0004315)1.80922451
142Recurrent lower respiratory tract infections (HP:0002783)1.80365062
143Agnosia (HP:0010524)1.80232344
144Abnormality of T cell physiology (HP:0011840)1.79867047
145Subacute progressive viral hepatitis (HP:0006572)1.79394432
146Ectropion (HP:0000656)1.79019039
147Conjunctival telangiectasia (HP:0000524)1.79018151
148Basal ganglia calcification (HP:0002135)1.78758138
149Meningitis (HP:0001287)1.77931413
150Purpura (HP:0000979)1.77801811
151Keratoconjunctivitis sicca (HP:0001097)1.77697834
152Osteomalacia (HP:0002749)1.76913207
153Abnormality of the axillary hair (HP:0100134)1.76029235
154Abnormality of secondary sexual hair (HP:0009888)1.76029235
155Submucous cleft hard palate (HP:0000176)1.75974464
156Slow saccadic eye movements (HP:0000514)1.73579116
157Upper limb muscle weakness (HP:0003484)1.73536443
158Pruritus (HP:0000989)1.69887180
159Conical tooth (HP:0000698)1.69875634
160Segmental peripheral demyelination/remyelination (HP:0003481)1.69532256
161Akinesia (HP:0002304)1.68188805
162Chronic diarrhea (HP:0002028)1.65442635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.73133506
2IRAK43.11541533
3RIPK43.03495424
4BLK3.00573210
5PBK2.93303827
6IRAK32.58794033
7CASK2.46429043
8MST42.34729958
9PDK22.29448175
10IKBKE2.25106597
11ADRBK22.20801646
12GRK62.15595107
13SIK32.07581803
14GRK72.03057541
15STK391.94877299
16EPHB11.93660236
17EIF2AK21.86715613
18PRPF4B1.85881355
19PKN11.83964055
20TXK1.83044542
21TBK11.82747679
22YES11.82487787
23MAP3K21.81542867
24TYK21.81201897
25FGR1.75588232
26TRPM71.74614616
27IKBKB1.72794965
28MAP4K11.70816256
29WNK41.68161616
30OXSR11.63360986
31GRK11.61926303
32ITK1.59474030
33TRIM281.58739237
34KSR21.58106476
35BMPR21.56390329
36INSRR1.51638413
37EIF2AK31.45786302
38RAF11.45628414
39FRK1.40366737
40CLK11.37243059
41FGFR31.34518193
42BMPR1B1.33775177
43MAP2K31.33707735
44NUAK11.33234243
45EPHA21.28610785
46STK241.28480282
47MARK31.27885595
48ZAK1.27862265
49CSK1.27468943
50TAOK31.23899071
51MST1R1.21968197
52KIT1.15977206
53JAK11.15815753
54STK101.15584544
55MAP3K31.08518815
56KSR11.06882558
57BRD41.06627934
58PTK2B1.05741183
59PIK3CG1.03859308
60BCR1.01208571
61MAPKAPK50.99328250
62ACVR1B0.94864087
63JAK30.91835719
64ERBB40.90900060
65LYN0.90809804
66MAPK70.87967440
67MAP3K120.86039111
68MAP3K10.84533454
69SGK4940.83842766
70SGK2230.83842766
71LCK0.82328631
72HCK0.82309167
73MATK0.81345161
74PRKCE0.78755683
75MET0.78296979
76NEK90.77681023
77CDK90.77067098
78IRAK20.76617701
79ARAF0.75755074
80TNK20.74102569
81PRKCQ0.72906541
82TEC0.72624369
83CSF1R0.71895060
84ABL10.68085780
85CAMK1D0.65646962
86PDK10.64595691
87MAP3K50.63642616
88CDK60.62741250
89NEK60.62343644
90SYK0.62253775
91MAPK150.61702910
92MUSK0.60923178
93MAPK120.60157229
94PIM20.59957030
95TNIK0.59591286
96CHUK0.59243168
97LATS10.58180681
98NLK0.57794472
99STK40.57734533
100SGK20.57289535
101FGFR20.56828942
102FES0.56498862
103PRKAA20.55234916
104PRKCD0.54648215
105PIK3CA0.54619059
106CAMK2D0.54500458
107JAK20.54486953
108ERN10.52478805
109PDPK10.48630820
110RPS6KA50.48550882
111IRAK10.47925262
112GSK3A0.47737588
113CAMK2B0.47357612
114ERBB30.46969044
115BRSK20.46699040
116PRKG10.45295025
117TGFBR20.44671318
118MAPKAPK20.43521906
119EIF2AK10.43132537
120MAP3K130.41307783
121IGF1R0.39594770
122MAPK40.39343378
123EPHA30.38957958
124BTK0.38474532
125WNK10.38403220
126AKT30.38250943
127MOS0.38069786
128SGK10.37913274
129PRKD10.37087392
130CDK30.36600671
131ZAP700.36594147
132CCNB10.36161110
133OBSCN0.36060061
134CAMK2G0.35249215
135MAPK110.35131519
136STK160.34791548
137CAMKK20.34785417
138STK30.34427374
139CAMK1G0.34373977
140EGFR0.33665788
141PIM10.33496043
142SCYL20.33296238
143CAMK2A0.32610452
144FGFR40.31504957

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.19451738
2Steroid biosynthesis_Homo sapiens_hsa001003.15810316
3Histidine metabolism_Homo sapiens_hsa003402.23739743
4Fatty acid elongation_Homo sapiens_hsa000622.22615761
5Graft-versus-host disease_Homo sapiens_hsa053322.22429399
6Rheumatoid arthritis_Homo sapiens_hsa053232.06043156
7Sphingolipid metabolism_Homo sapiens_hsa006002.02624466
8Primary immunodeficiency_Homo sapiens_hsa053401.91335748
9Pertussis_Homo sapiens_hsa051331.88634297
10Leishmaniasis_Homo sapiens_hsa051401.87066345
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.76126833
12Allograft rejection_Homo sapiens_hsa053301.75494906
13Phagosome_Homo sapiens_hsa041451.74730308
14Ether lipid metabolism_Homo sapiens_hsa005651.71903529
15Lysosome_Homo sapiens_hsa041421.68816755
16Malaria_Homo sapiens_hsa051441.63467580
17Vitamin digestion and absorption_Homo sapiens_hsa049771.62255975
18T cell receptor signaling pathway_Homo sapiens_hsa046601.60808042
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56454011
20Complement and coagulation cascades_Homo sapiens_hsa046101.53287064
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51290933
22Sulfur metabolism_Homo sapiens_hsa009201.50808304
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50075401
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49668801
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.46293573
26Mineral absorption_Homo sapiens_hsa049781.43557325
27Autoimmune thyroid disease_Homo sapiens_hsa053201.41299961
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41141632
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40820997
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38467583
31Antigen processing and presentation_Homo sapiens_hsa046121.37948972
32Shigellosis_Homo sapiens_hsa051311.37535257
33Asthma_Homo sapiens_hsa053101.37291519
34Other glycan degradation_Homo sapiens_hsa005111.36623503
35Platelet activation_Homo sapiens_hsa046111.35240342
36Tuberculosis_Homo sapiens_hsa051521.35147264
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34597330
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33393074
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29126816
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28081535
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.24211726
42ABC transporters_Homo sapiens_hsa020101.22667460
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20753519
44Peroxisome_Homo sapiens_hsa041461.20373436
45Hematopoietic cell lineage_Homo sapiens_hsa046401.19739523
46Osteoclast differentiation_Homo sapiens_hsa043801.17957669
47beta-Alanine metabolism_Homo sapiens_hsa004101.16834808
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15300185
49Legionellosis_Homo sapiens_hsa051341.14445732
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14427577
51African trypanosomiasis_Homo sapiens_hsa051431.13871487
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13625524
53Vitamin B6 metabolism_Homo sapiens_hsa007501.13201178
54Arachidonic acid metabolism_Homo sapiens_hsa005901.11912110
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.11614656
56Hepatitis B_Homo sapiens_hsa051611.10703250
57Caffeine metabolism_Homo sapiens_hsa002321.10416868
58Measles_Homo sapiens_hsa051621.09734955
59Herpes simplex infection_Homo sapiens_hsa051681.09566526
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08717203
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08656959
62Collecting duct acid secretion_Homo sapiens_hsa049661.08601106
63Acute myeloid leukemia_Homo sapiens_hsa052211.06560855
64Retinol metabolism_Homo sapiens_hsa008301.03789283
65Viral myocarditis_Homo sapiens_hsa054161.02860281
66Nitrogen metabolism_Homo sapiens_hsa009101.02762204
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01855817
68Tryptophan metabolism_Homo sapiens_hsa003800.99425651
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98229675
70Linoleic acid metabolism_Homo sapiens_hsa005910.96689497
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95608741
72PPAR signaling pathway_Homo sapiens_hsa033200.92492973
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90372944
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.89323060
75Pancreatic cancer_Homo sapiens_hsa052120.88778030
76Starch and sucrose metabolism_Homo sapiens_hsa005000.88482286
77Non-small cell lung cancer_Homo sapiens_hsa052230.88372780
78Renin-angiotensin system_Homo sapiens_hsa046140.87206865
79* Inositol phosphate metabolism_Homo sapiens_hsa005620.86929330
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85732014
81Regulation of autophagy_Homo sapiens_hsa041400.85697538
82Salmonella infection_Homo sapiens_hsa051320.84788830
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84334363
84* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82864377
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81968722
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81749632
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81258753
88Influenza A_Homo sapiens_hsa051640.80675614
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80305352
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.80147160
91Hepatitis C_Homo sapiens_hsa051600.78391835
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78299549
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77709237
94Fatty acid biosynthesis_Homo sapiens_hsa000610.77344437
95Fatty acid metabolism_Homo sapiens_hsa012120.76924968
96Type I diabetes mellitus_Homo sapiens_hsa049400.72021952
97Chemical carcinogenesis_Homo sapiens_hsa052040.71199288
98Renal cell carcinoma_Homo sapiens_hsa052110.70191715
99Propanoate metabolism_Homo sapiens_hsa006400.69813188
100Chemokine signaling pathway_Homo sapiens_hsa040620.69398980
101Dorso-ventral axis formation_Homo sapiens_hsa043200.69097304
102Fatty acid degradation_Homo sapiens_hsa000710.66533143
103TNF signaling pathway_Homo sapiens_hsa046680.65282314
104Circadian rhythm_Homo sapiens_hsa047100.64492415
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63208320
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62331397
107Chronic myeloid leukemia_Homo sapiens_hsa052200.61471122
108Prolactin signaling pathway_Homo sapiens_hsa049170.58317718
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.57877873
110Oxidative phosphorylation_Homo sapiens_hsa001900.55696000
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55067710
112Arginine and proline metabolism_Homo sapiens_hsa003300.54492209
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54361472
114FoxO signaling pathway_Homo sapiens_hsa040680.54300621
115Insulin resistance_Homo sapiens_hsa049310.54076223
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51252805
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50855938
118Toxoplasmosis_Homo sapiens_hsa051450.48136931
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47813688
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46545302
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45912248
122Apoptosis_Homo sapiens_hsa042100.45051416
123Epstein-Barr virus infection_Homo sapiens_hsa051690.45038470
124Protein export_Homo sapiens_hsa030600.44014566
125Non-homologous end-joining_Homo sapiens_hsa034500.43343251
126mTOR signaling pathway_Homo sapiens_hsa041500.42461270
127Viral carcinogenesis_Homo sapiens_hsa052030.42444948
128Glycerolipid metabolism_Homo sapiens_hsa005610.41881213
129B cell receptor signaling pathway_Homo sapiens_hsa046620.41365304
130Phenylalanine metabolism_Homo sapiens_hsa003600.40733645
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.39980315
132Fat digestion and absorption_Homo sapiens_hsa049750.39672158
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.38845515

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