MTMR10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.65203271
2central nervous system myelination (GO:0022010)5.65203271
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.37619115
4L-phenylalanine catabolic process (GO:0006559)5.37619115
5fatty acid elongation (GO:0030497)5.29431188
6L-phenylalanine metabolic process (GO:0006558)4.82632024
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.82632024
8positive regulation of gamma-delta T cell activation (GO:0046645)4.70443496
9detection of molecule of bacterial origin (GO:0032490)4.52851454
10negative regulation of cell killing (GO:0031342)4.39071826
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.39071826
12modulation by symbiont of host defense response (GO:0052031)4.33166670
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.33166670
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.33166670
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.33166670
16modulation by symbiont of host immune response (GO:0052553)4.33166670
17positive regulation by symbiont of host defense response (GO:0052509)4.33166670
18aromatic amino acid family catabolic process (GO:0009074)4.21892832
19alpha-linolenic acid metabolic process (GO:0036109)4.17959043
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13452918
21macrophage activation involved in immune response (GO:0002281)3.96710896
22bile acid biosynthetic process (GO:0006699)3.76061936
23cellular extravasation (GO:0045123)3.71347954
24very long-chain fatty acid metabolic process (GO:0000038)3.70135245
25detection of external biotic stimulus (GO:0098581)3.66530599
26detection of other organism (GO:0098543)3.65690825
27long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.65387973
28peptidyl-glutamic acid carboxylation (GO:0017187)3.63297160
29protein carboxylation (GO:0018214)3.63297160
30cholesterol biosynthetic process (GO:0006695)3.59122484
31negative regulation of fibrinolysis (GO:0051918)3.58512644
32fatty-acyl-CoA biosynthetic process (GO:0046949)3.58475197
33regulation of gamma-delta T cell activation (GO:0046643)3.58099589
34glyoxylate metabolic process (GO:0046487)3.56706633
35plasma lipoprotein particle clearance (GO:0034381)3.56228796
36regulation of B cell receptor signaling pathway (GO:0050855)3.55388150
37neutrophil activation involved in immune response (GO:0002283)3.55074726
38microglial cell activation (GO:0001774)3.53611456
39tyrosine metabolic process (GO:0006570)3.51680249
40myelination (GO:0042552)3.50380761
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.50214713
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.50175992
43axon ensheathment (GO:0008366)3.49505059
44ensheathment of neurons (GO:0007272)3.49505059
45import into cell (GO:0098657)3.46712111
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.45718296
47coenzyme catabolic process (GO:0009109)3.44839286
48heme transport (GO:0015886)3.43947960
49cysteine metabolic process (GO:0006534)3.42463049
50response to peptidoglycan (GO:0032494)3.42047448
51response to methylmercury (GO:0051597)3.39408850
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34472730
53negative regulation of erythrocyte differentiation (GO:0045647)3.33643919
54sulfur amino acid catabolic process (GO:0000098)3.32128084
55regulation of gamma-delta T cell differentiation (GO:0045586)3.29640837
56macrophage activation (GO:0042116)3.26834275
57detection of biotic stimulus (GO:0009595)3.25369464
58bile acid metabolic process (GO:0008206)3.23149344
59regulation of fibrinolysis (GO:0051917)3.20902683
60positive regulation of cellular amide metabolic process (GO:0034250)3.20641434
61sterol biosynthetic process (GO:0016126)3.19866453
62fatty-acyl-CoA metabolic process (GO:0035337)3.16788741
63tryptophan catabolic process (GO:0006569)3.16685126
64indole-containing compound catabolic process (GO:0042436)3.16685126
65indolalkylamine catabolic process (GO:0046218)3.16685126
66detection of bacterium (GO:0016045)3.16067476
67high-density lipoprotein particle remodeling (GO:0034375)3.13900362
68negative regulation of interleukin-12 production (GO:0032695)3.12771432
69regulation of protein activation cascade (GO:2000257)3.12368181
70thioester biosynthetic process (GO:0035384)3.11916572
71acyl-CoA biosynthetic process (GO:0071616)3.11916572
72complement activation, alternative pathway (GO:0006957)3.10882118
73response to lipoprotein particle (GO:0055094)3.10583241
74cholesterol efflux (GO:0033344)3.08330186
75short-chain fatty acid metabolic process (GO:0046459)3.06932441
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06600518
77response to host immune response (GO:0052572)3.06600518
78tryptophan metabolic process (GO:0006568)3.05371913
79regulation of interferon-beta biosynthetic process (GO:0045357)3.03964196
80L-amino acid import (GO:0043092)3.02298236
81urea metabolic process (GO:0019627)3.01861297
82urea cycle (GO:0000050)3.01861297
83aromatic amino acid family metabolic process (GO:0009072)3.00897850
84response to muramyl dipeptide (GO:0032495)2.99253120
85regulation of triglyceride catabolic process (GO:0010896)2.98628727
86positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98467512
87reverse cholesterol transport (GO:0043691)2.98100857
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98081709
89antigen processing and presentation of endogenous antigen (GO:0019883)2.96890236
90kynurenine metabolic process (GO:0070189)2.96704260
91long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.95968203
92cellular glucuronidation (GO:0052695)2.95749411
93regulation of macrophage cytokine production (GO:0010935)2.95720719
94ethanol oxidation (GO:0006069)2.95320968
95homocysteine metabolic process (GO:0050667)2.94930047
96regulation of complement activation (GO:0030449)2.94128270
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93557632
98response to host (GO:0075136)2.93557632
99response to host defenses (GO:0052200)2.93557632
100positive regulation of macrophage cytokine production (GO:0060907)2.93245221
101negative regulation of lymphocyte mediated immunity (GO:0002707)2.92573160
102negative regulation of lipase activity (GO:0060192)2.91586519
103fibrinolysis (GO:0042730)2.91284465
104regulation of cholesterol esterification (GO:0010872)2.90775905
105very-low-density lipoprotein particle assembly (GO:0034379)2.89280582
106acetyl-CoA metabolic process (GO:0006084)2.89276666
107regulation of lipoprotein metabolic process (GO:0050746)2.85289961
108B cell receptor signaling pathway (GO:0050853)2.84203766
109cofactor catabolic process (GO:0051187)2.83850569
110regulation of cholesterol metabolic process (GO:0090181)2.83604855
111cholesterol metabolic process (GO:0008203)2.80723750
112positive regulation of Rap GTPase activity (GO:0032854)2.80245550
113positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77404396
114positive regulation of mast cell activation (GO:0033005)2.76293509
115protein-lipid complex remodeling (GO:0034368)2.75360017
116macromolecular complex remodeling (GO:0034367)2.75360017
117plasma lipoprotein particle remodeling (GO:0034369)2.75360017
118regulation of cholesterol biosynthetic process (GO:0045540)2.75245327
119cholesterol homeostasis (GO:0042632)2.75069070
120amyloid precursor protein metabolic process (GO:0042982)2.74950557
121positive regulation of lipoprotein lipase activity (GO:0051006)2.74544220
122positive regulation of triglyceride lipase activity (GO:0061365)2.74544220
123acylglycerol homeostasis (GO:0055090)2.72579402
124triglyceride homeostasis (GO:0070328)2.72579402
125myelin maintenance (GO:0043217)2.71590598
126sterol homeostasis (GO:0055092)2.71220578
127creatine metabolic process (GO:0006600)2.71060984
128leukocyte migration involved in inflammatory response (GO:0002523)2.70723231
129cellular ketone body metabolic process (GO:0046950)2.70414291
130nitrogen cycle metabolic process (GO:0071941)2.69693373
131acyl-CoA metabolic process (GO:0006637)2.69434596
132thioester metabolic process (GO:0035383)2.69434596
133protein-lipid complex assembly (GO:0065005)2.69388664
134regulation of T-helper 2 cell differentiation (GO:0045628)2.67582439
135cellular biogenic amine catabolic process (GO:0042402)2.67400090
136amine catabolic process (GO:0009310)2.67400090
137uronic acid metabolic process (GO:0006063)2.67337558
138glucuronate metabolic process (GO:0019585)2.67337558
139myeloid cell activation involved in immune response (GO:0002275)2.66433651
140cellular modified amino acid catabolic process (GO:0042219)2.65735261
141alpha-amino acid catabolic process (GO:1901606)2.65133078
142positive regulation of fatty acid beta-oxidation (GO:0032000)2.64535189
143sterol metabolic process (GO:0016125)2.63763726
144negative regulation of leukocyte mediated immunity (GO:0002704)2.63551086
145positive thymic T cell selection (GO:0045059)2.63179542
146iron coordination entity transport (GO:1901678)2.61978578
147phospholipid homeostasis (GO:0055091)2.61780178
148phospholipid efflux (GO:0033700)2.61672510
149regulation of plasminogen activation (GO:0010755)2.61441663
150cellular response to cholesterol (GO:0071397)2.61365782
151antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61313886
152response to mercury ion (GO:0046689)2.61278620
153cellular response to epinephrine stimulus (GO:0071872)2.60724224
154regulation of beta-amyloid formation (GO:1902003)2.60101364
155regulation of myeloid leukocyte mediated immunity (GO:0002886)2.59077583
156negative regulation of T cell mediated immunity (GO:0002710)2.59044987
157neutrophil activation (GO:0042119)2.58648190
158regulation of leukocyte degranulation (GO:0043300)2.54382330
159regulation of mast cell degranulation (GO:0043304)2.53248715
160negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.51864267
161germinal center formation (GO:0002467)2.48148250
162negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.46405248
163negative regulation of T-helper cell differentiation (GO:0045623)2.46405248
164regulation of ARF protein signal transduction (GO:0032012)2.45941045
165production of molecular mediator involved in inflammatory response (GO:0002532)2.43893816
166neutrophil mediated immunity (GO:0002446)2.43223354
167regulation of necroptotic process (GO:0060544)2.42150970
168response to interleukin-15 (GO:0070672)2.42011860
169leukocyte aggregation (GO:0070486)2.41992797
170regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.40804545
171positive regulation of mast cell activation involved in immune response (GO:0033008)2.39635983
172positive regulation of mast cell degranulation (GO:0043306)2.39635983
173activated T cell proliferation (GO:0050798)2.39251066
174regulation of platelet aggregation (GO:0090330)2.38868043
175regulation of Rap GTPase activity (GO:0032317)2.38653800
176positive T cell selection (GO:0043368)2.37709423
177lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36528289
178cellular response to ethanol (GO:0071361)2.36214201
179positive regulation of toll-like receptor signaling pathway (GO:0034123)2.35803069
180granulocyte activation (GO:0036230)2.35104349
181regulation of mast cell activation involved in immune response (GO:0033006)2.34531551
182regulation of amyloid precursor protein catabolic process (GO:1902991)2.30874141
183hypotonic response (GO:0006971)2.30795078
184regulation of mast cell activation (GO:0033003)2.28658726
185regulation of cellular amide metabolic process (GO:0034248)2.27000620
186negative regulation of type 2 immune response (GO:0002829)2.26828831
187negative thymic T cell selection (GO:0045060)2.26517484
188regulation of regulated secretory pathway (GO:1903305)2.24702115
189regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.23575690
190negative regulation of toll-like receptor signaling pathway (GO:0034122)2.23226748
191regulation of tolerance induction (GO:0002643)2.21003532
192negative T cell selection (GO:0043383)2.19187159
193negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.18911292
194positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.18907686
195positive regulation of receptor recycling (GO:0001921)2.18718718
196JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.18614121
197T-helper 1 type immune response (GO:0042088)2.18367022
198positive regulation of B cell differentiation (GO:0045579)2.17821603
199negative regulation of interleukin-17 production (GO:0032700)2.17801793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.17514173
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.98561084
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.70164167
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.31426355
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.23415009
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10590250
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.09232704
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.90424245
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.62010553
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42180904
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.38867760
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.33316656
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.31044546
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.23306518
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20803873
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15797664
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01691124
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97875418
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97292607
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.96842249
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.94272379
22NRF2_20460467_ChIP-Seq_MEFs_Mouse1.94272379
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87868128
24SCL_19346495_ChIP-Seq_HPC-7_Human1.85988736
25* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85295933
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81765340
27SPI1_23127762_ChIP-Seq_K562_Human1.78971796
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.78686371
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77105343
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76800525
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73991949
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.73257888
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.73252180
34CLOCK_20551151_ChIP-Seq_293T_Human1.73218479
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67907445
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66638185
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65948492
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65495457
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63388288
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56479838
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.54387677
42* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53555600
43VDR_24763502_ChIP-Seq_THP-1_Human1.51068763
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48331744
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46129883
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.44888947
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.44746762
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.44239639
49TCF7_22412390_ChIP-Seq_EML_Mouse1.42528024
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.39729658
51DROSHA_22980978_ChIP-Seq_HELA_Human1.36834383
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.35573080
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34616808
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34404125
55CJUN_26792858_Chip-Seq_BT549_Human1.34380614
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33854241
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33539694
58AR_21572438_ChIP-Seq_LNCaP_Human1.32808212
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32295548
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29164899
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28176754
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27552527
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.25093570
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.24961527
65GATA1_22025678_ChIP-Seq_K562_Human1.24378547
66GATA1_19941826_ChIP-Seq_K562_Human1.24180007
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23278714
68* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22470060
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21699371
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21175753
71KDM2B_26808549_Chip-Seq_DND41_Human1.20416688
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18497044
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.18449655
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18372992
75EZH2_22144423_ChIP-Seq_EOC_Human1.18111546
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17845695
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17647804
78GATA2_19941826_ChIP-Seq_K562_Human1.16462624
79AHR_22903824_ChIP-Seq_MCF-7_Human1.16254985
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16138547
81* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15952857
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15381318
83GBX2_23144817_ChIP-Seq_PC3_Human1.15323858
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14521824
85* SOX2_20726797_ChIP-Seq_SW620_Human1.11245504
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.11083907
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10845805
88MYB_26560356_Chip-Seq_TH2_Human1.10319302
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.10016443
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10004739
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.09389778
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09191232
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07104041
94PU_27001747_Chip-Seq_BMDM_Mouse1.06146562
95VDR_21846776_ChIP-Seq_THP-1_Human1.05310335
96GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05299378
97* TP63_23658742_ChIP-Seq_EP156T_Human1.05094323
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.04900719
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04043015
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03950017
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03660183
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03633967
103HTT_18923047_ChIP-ChIP_STHdh_Human1.03568887
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03509420
105TP53_18474530_ChIP-ChIP_U2OS_Human1.03106183
106KDM2B_26808549_Chip-Seq_K562_Human1.02469103
107GATA3_27048872_Chip-Seq_THYMUS_Human1.01636101
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00908716
109MAF_26560356_Chip-Seq_TH1_Human1.00210951
110TAF15_26573619_Chip-Seq_HEK293_Human1.00131461
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97701244
112RXR_22108803_ChIP-Seq_LS180_Human0.97447634
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96856434
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96329441
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95518463
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95338064
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94973735
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93546610
119TP53_16413492_ChIP-PET_HCT116_Human0.93279865
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.93142593
121SPI1_23547873_ChIP-Seq_NB4_Human0.92976148
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92882632
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92092758
124VDR_24787735_ChIP-Seq_THP-1_Human0.91916432
125GATA4_25053715_ChIP-Seq_YYC3_Human0.91499340
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.91083843
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90871111
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90812501
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90243872
130MYB_26560356_Chip-Seq_TH1_Human0.88455673
131ER_23166858_ChIP-Seq_MCF-7_Human0.88414742
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88306614
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87846866
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87447737
135KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86221981
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85405571
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84812754
138JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84355422
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84293029
140PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84233863
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83427677
142* TBX20_22080862_ChIP-Seq_HEART_Mouse0.83152739
143* TBX20_22328084_ChIP-Seq_HEART_Mouse0.83152739
144* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82701055
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82604661
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82004953
147STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80304049
148UTX_26944678_Chip-Seq_JUKART_Human0.80215808
149WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79981862
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79193916
151FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78994814
152CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78653333
153IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78361248
154STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78126008
155EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77776222
156RUNX_20019798_ChIP-Seq_JUKART_Human0.77444845
157PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76779129
158CDX2_22108803_ChIP-Seq_LS180_Human0.76627391
159CBP_21632823_ChIP-Seq_H3396_Human0.75821259
160CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75797768
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.75136813
162POU3F2_20337985_ChIP-ChIP_501MEL_Human0.74641738
163GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73270001
164STAT3_23295773_ChIP-Seq_U87_Human0.72753495
165* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.72564766
166SMAD4_21741376_ChIP-Seq_HESCs_Human0.72451265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.00691255
2MP0005360_urolithiasis4.80724664
3MP0003724_increased_susceptibility_to4.30573236
4MP0005365_abnormal_bile_salt3.67316338
5MP0005085_abnormal_gallbladder_physiolo3.66988156
6MP0003806_abnormal_nucleotide_metabolis3.43391584
7MP0003303_peritoneal_inflammation3.43138028
8MP0009840_abnormal_foam_cell3.26565429
9MP0003690_abnormal_glial_cell3.18676232
10MP0000920_abnormal_myelination3.10098269
11MP0008875_abnormal_xenobiotic_pharmacok3.03882216
12MP0003436_decreased_susceptibility_to2.82505236
13MP0008438_abnormal_cutaneous_collagen2.81159523
14MP0003252_abnormal_bile_duct2.72416318
15MP0001835_abnormal_antigen_presentation2.57475009
16MP0003828_pulmonary_edema2.56993790
17MP0000569_abnormal_digit_pigmentation2.37541062
18MP0002419_abnormal_innate_immunity2.37220896
19MP0003195_calcinosis2.21958778
20MP0010329_abnormal_lipoprotein_level2.10889611
21MP0005332_abnormal_amino_acid2.07069838
22MP0005058_abnormal_lysosome_morphology2.05697504
23MP0005083_abnormal_biliary_tract2.02923394
24MP0008260_abnormal_autophagy2.02462513
25MP0005464_abnormal_platelet_physiology1.97878747
26MP0003950_abnormal_plasma_membrane1.97588438
27MP0001800_abnormal_humoral_immune1.96874202
28MP0005025_abnormal_response_to1.96760909
29MP0005000_abnormal_immune_tolerance1.93850240
30MP0001666_abnormal_nutrient_absorption1.91426265
31MP0010678_abnormal_skin_adnexa1.81587573
32MP0000685_abnormal_immune_system1.81189537
33MP0002118_abnormal_lipid_homeostasis1.76670369
34MP0005387_immune_system_phenotype1.75985267
35MP0001790_abnormal_immune_system1.75985267
36MP0005171_absent_coat_pigmentation1.75914829
37MP0003183_abnormal_peptide_metabolism1.74819999
38MP0002723_abnormal_immune_serum1.74720642
39MP0009785_altered_susceptibility_to1.73962937
40MP0003191_abnormal_cellular_cholesterol1.73049285
41MP0000383_abnormal_hair_follicle1.71500973
42MP0001533_abnormal_skeleton_physiology1.71387380
43MP0005671_abnormal_response_to1.66303686
44MP0009384_cardiac_valve_regurgitation1.65861639
45MP0005670_abnormal_white_adipose1.65709415
46MP0002452_abnormal_antigen_presenting1.64762193
47MP0002420_abnormal_adaptive_immunity1.63331591
48MP0003136_yellow_coat_color1.62687371
49MP0001819_abnormal_immune_cell1.60270059
50MP0002998_abnormal_bone_remodeling1.57073067
51MP0004510_myositis1.52556081
52MP0001661_extended_life_span1.50641086
53MP0004381_abnormal_hair_follicle1.50399585
54MP0000604_amyloidosis1.48925688
55MP0002148_abnormal_hypersensitivity_rea1.46927468
56MP0005408_hypopigmentation1.46076789
57MP0000647_abnormal_sebaceous_gland1.45965182
58MP0003705_abnormal_hypodermis_morpholog1.42557566
59MP0003329_amyloid_beta_deposits1.42310725
60MP0005275_abnormal_skin_tensile1.40767131
61MP0004947_skin_inflammation1.38845691
62MP0003763_abnormal_thymus_physiology1.35253336
63MP0003634_abnormal_glial_cell1.34569763
64MP0000609_abnormal_liver_physiology1.34553956
65MP0004883_abnormal_blood_vessel1.32978538
66MP0005166_decreased_susceptibility_to1.32454702
67MP0004134_abnormal_chest_morphology1.32200465
68MP0002405_respiratory_system_inflammati1.30744747
69MP0004272_abnormal_basement_membrane1.29770294
70MP0005409_darkened_coat_color1.29723734
71MP0004019_abnormal_vitamin_homeostasis1.29259667
72MP0009115_abnormal_fat_cell1.28872934
73MP0003300_gastrointestinal_ulcer1.28753182
74MP0006082_CNS_inflammation1.26010252
75MP0010155_abnormal_intestine_physiology1.25668151
76MP0000465_gastrointestinal_hemorrhage1.25433364
77MP0003868_abnormal_feces_composition1.24603739
78MP0004484_altered_response_of1.24205004
79MP0002295_abnormal_pulmonary_circulatio1.23762480
80MP0009278_abnormal_bone_marrow1.23034742
81MP0003045_fibrosis1.21929926
82MP0008004_abnormal_stomach_pH1.20302224
83MP0005451_abnormal_body_composition1.18931397
84MP0000716_abnormal_immune_system1.17834128
85MP0005623_abnormal_meninges_morphology1.16721888
86MP0001845_abnormal_inflammatory_respons1.14909599
87MP0001545_abnormal_hematopoietic_system1.14554507
88MP0005397_hematopoietic_system_phenotyp1.14554507
89MP0002398_abnormal_bone_marrow1.13852462
90MP0005584_abnormal_enzyme/coenzyme_acti1.13812580
91MP0004742_abnormal_vestibular_system1.12601469
92MP0004885_abnormal_endolymph1.11528454
93MP0003011_delayed_dark_adaptation1.09422184
94MP0004185_abnormal_adipocyte_glucose1.09361538
95MP0000343_altered_response_to1.08998921
96MP0003866_abnormal_defecation1.07800509
97MP0002138_abnormal_hepatobiliary_system1.06190651
98MP0005666_abnormal_adipose_tissue1.05803007
99MP0000015_abnormal_ear_pigmentation1.05664137
100MP0001299_abnormal_eye_distance/1.04896178
101MP0002332_abnormal_exercise_endurance1.04363817
102MP0001542_abnormal_bone_strength1.03346856
103MP0003646_muscle_fatigue1.02224212
104MP0003632_abnormal_nervous_system1.02055512
105MP0003879_abnormal_hair_cell1.00348446
106MP0003633_abnormal_nervous_system0.99514217
107MP0001958_emphysema0.99296208
108MP0004036_abnormal_muscle_relaxation0.98399239
109MP0002168_other_aberrant_phenotype0.98361040
110MP0000462_abnormal_digestive_system0.97361008
111MP0005257_abnormal_intraocular_pressure0.96506451
112MP0000579_abnormal_nail_morphology0.94949694
113MP0005319_abnormal_enzyme/_coenzyme0.93965331
114MP0009643_abnormal_urine_homeostasis0.93713852
115MP0002090_abnormal_vision0.93580443
116MP0002132_abnormal_respiratory_system0.93386433
117MP0005388_respiratory_system_phenotype0.93011828
118MP0002133_abnormal_respiratory_system0.93011828
119MP0005535_abnormal_body_temperature0.91185773
120MP0008469_abnormal_protein_level0.90933975
121MP0000249_abnormal_blood_vessel0.90791677
122MP0002060_abnormal_skin_morphology0.89464724
123MP0000427_abnormal_hair_cycle0.89436057
124MP0000689_abnormal_spleen_morphology0.88734597
125MP0002396_abnormal_hematopoietic_system0.88278431
126MP0001243_abnormal_dermal_layer0.87165953
127MP0010368_abnormal_lymphatic_system0.86734345
128MP0008569_lethality_at_weaning0.82803114
129MP0009697_abnormal_copulation0.82452626
130MP0003656_abnormal_erythrocyte_physiolo0.82444894
131MP0002722_abnormal_immune_system0.82425844
132MP0002429_abnormal_blood_cell0.81437509
133MP0008874_decreased_physiological_sensi0.80716964
134MP0000733_abnormal_muscle_development0.80492462
135MP0003631_nervous_system_phenotype0.80181505
136MP0003453_abnormal_keratinocyte_physiol0.79820129
137MP0005174_abnormal_tail_pigmentation0.79283750
138MP0001851_eye_inflammation0.79238589
139MP0002896_abnormal_bone_mineralization0.78415240
140MP0005375_adipose_tissue_phenotype0.78147023
141MP0003075_altered_response_to0.78036185
142MP0000747_muscle_weakness0.77319847
143MP0005167_abnormal_blood-brain_barrier0.74160029
144MP0003172_abnormal_lysosome_physiology0.73750941
145MP0002971_abnormal_brown_adipose0.71941237
146MP0004859_abnormal_synaptic_plasticity0.71872637
147MP0000566_synostosis0.71588398
148MP0001853_heart_inflammation0.71364401
149MP0000377_abnormal_hair_follicle0.71308289
150MP0001346_abnormal_lacrimal_gland0.71096602
151MP0000858_altered_metastatic_potential0.70699047
152MP0003448_altered_tumor_morphology0.70604992
153MP0002166_altered_tumor_susceptibility0.70194343
154MP0001324_abnormal_eye_pigmentation0.69567225
155MP0001177_atelectasis0.68760763
156MP0002933_joint_inflammation0.68741132
157MP0009763_increased_sensitivity_to0.68721394
158MP0002098_abnormal_vibrissa_morphology0.67624205
159MP0005395_other_phenotype0.67416167
160MP0009764_decreased_sensitivity_to0.67187887
161MP0005595_abnormal_vascular_smooth0.65533538
162MP0003091_abnormal_cell_migration0.65209078
163MP0003566_abnormal_cell_adhesion0.64673743
164MP0005164_abnormal_response_to0.64633396
165MP0005503_abnormal_tendon_morphology0.64476636
166MP0000598_abnormal_liver_morphology0.63390246
167MP0004130_abnormal_muscle_cell0.60829608
168MP0005023_abnormal_wound_healing0.60799371
169MP0005508_abnormal_skeleton_morphology0.60537788
170MP0003279_aneurysm0.60051604
171MP0003937_abnormal_limbs/digits/tail_de0.59409773

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.17790228
2Intrahepatic cholestasis (HP:0001406)5.13723613
3Xanthomatosis (HP:0000991)5.09168145
4Eczematoid dermatitis (HP:0000976)4.66277156
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.49654225
6Hyperlipoproteinemia (HP:0010980)4.44749616
7Recurrent bacterial skin infections (HP:0005406)4.01719998
8Spontaneous hematomas (HP:0007420)3.98432997
9Neurofibrillary tangles (HP:0002185)3.91427174
10Recurrent abscess formation (HP:0002722)3.85179897
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.74156729
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.74156729
13Myositis (HP:0100614)3.72770553
14Orchitis (HP:0100796)3.68770093
15Complement deficiency (HP:0004431)3.60715500
16Recurrent gram-negative bacterial infections (HP:0005420)3.60597249
17Retrobulbar optic neuritis (HP:0100654)3.50082022
18Optic neuritis (HP:0100653)3.50082022
19Hypobetalipoproteinemia (HP:0003563)3.46442591
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44556854
21Abnormality of macrophages (HP:0004311)3.43306458
22Premature rupture of membranes (HP:0001788)3.38756804
23Prolonged partial thromboplastin time (HP:0003645)3.34144295
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.25387478
25Epidermoid cyst (HP:0200040)3.24118083
26Hypoalphalipoproteinemia (HP:0003233)3.16977812
27Hypolipoproteinemia (HP:0010981)3.11921931
28Prolonged bleeding time (HP:0003010)3.05968251
29Myocardial infarction (HP:0001658)3.03829198
30Abnormality of methionine metabolism (HP:0010901)3.00665280
31Gingival bleeding (HP:0000225)2.92735879
32Difficulty running (HP:0009046)2.90626631
33Fat malabsorption (HP:0002630)2.89870200
34Cerebral inclusion bodies (HP:0100314)2.86067981
35Papilledema (HP:0001085)2.84235712
36Gingivitis (HP:0000230)2.83359477
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.81792126
38Mediastinal lymphadenopathy (HP:0100721)2.81384410
39Abnormality of the corticospinal tract (HP:0002492)2.79766737
40Abnormality of serine family amino acid metabolism (HP:0010894)2.77845245
41Abnormality of glycine metabolism (HP:0010895)2.77845245
42Abnormality of sulfur amino acid metabolism (HP:0004339)2.71551438
43Joint hemorrhage (HP:0005261)2.70470092
44Abnormality of complement system (HP:0005339)2.68703445
45Muscle fiber splitting (HP:0003555)2.68468626
46Vascular calcification (HP:0004934)2.66729386
47Abnormality of the common coagulation pathway (HP:0010990)2.65835545
48Recurrent skin infections (HP:0001581)2.64901713
49Parakeratosis (HP:0001036)2.61477974
50Hyperammonemia (HP:0001987)2.60500101
51Gastrointestinal infarctions (HP:0005244)2.59050737
52Stomatitis (HP:0010280)2.58749466
53Coronal craniosynostosis (HP:0004440)2.58038108
54Recurrent fungal infections (HP:0002841)2.58025431
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.58017117
56Epistaxis (HP:0000421)2.57893132
57Cardiovascular calcification (HP:0011915)2.57064907
58Keratoconjunctivitis sicca (HP:0001097)2.55189291
59Hyperglycinemia (HP:0002154)2.52681765
60Premature skin wrinkling (HP:0100678)2.49972956
61T lymphocytopenia (HP:0005403)2.49260548
62Axonal loss (HP:0003447)2.48783284
63Hypercholesterolemia (HP:0003124)2.47143446
64Hyporeflexia of lower limbs (HP:0002600)2.47116338
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.47016657
66Meningitis (HP:0001287)2.45046432
67Elevated erythrocyte sedimentation rate (HP:0003565)2.44026777
68Steatorrhea (HP:0002570)2.43991321
69Systemic lupus erythematosus (HP:0002725)2.40893078
70Chronic obstructive pulmonary disease (HP:0006510)2.39148832
71Obstructive lung disease (HP:0006536)2.39148832
72Obstructive sleep apnea (HP:0002870)2.37921056
73Ketosis (HP:0001946)2.36622708
74Insidious onset (HP:0003587)2.34303140
75Termporal pattern (HP:0011008)2.34303140
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.31904814
77Chronic mucocutaneous candidiasis (HP:0002728)2.31744994
78Recurrent cutaneous fungal infections (HP:0011370)2.31744994
79Hypophosphatemic rickets (HP:0004912)2.29997570
80Conjugated hyperbilirubinemia (HP:0002908)2.29382448
81Peripheral demyelination (HP:0011096)2.29156266
82Vasculitis (HP:0002633)2.27777837
83Onion bulb formation (HP:0003383)2.27123304
84Cellulitis (HP:0100658)2.25643246
85Chest pain (HP:0100749)2.24568179
86Aplasia involving bones of the upper limbs (HP:0009823)2.22279406
87Aplasia of the phalanges of the hand (HP:0009802)2.22279406
88Aplasia involving bones of the extremities (HP:0009825)2.22279406
89Abnormality of binocular vision (HP:0011514)2.21709116
90Diplopia (HP:0000651)2.21709116
91Amyloidosis (HP:0011034)2.21439754
92Abnormality of T cell number (HP:0011839)2.21076580
93Pulmonary infiltrates (HP:0002113)2.21006457
94Arterial thrombosis (HP:0004420)2.20201448
95Abnormality of the intrinsic pathway (HP:0010989)2.19835269
96Hemorrhage of the eye (HP:0011885)2.19114848
97Keratoconjunctivitis (HP:0001096)2.18379858
98Increased IgE level (HP:0003212)2.16239008
99Hemoptysis (HP:0002105)2.16052691
100Slow saccadic eye movements (HP:0000514)2.15975301
101Hypoglycemic coma (HP:0001325)2.11703861
102Stridor (HP:0010307)2.11327573
103Encephalitis (HP:0002383)2.10964049
104Hemiplegia (HP:0002301)2.09981000
105Turricephaly (HP:0000262)2.09604829
106Back pain (HP:0003418)2.08163441
107Skin nodule (HP:0200036)2.07786009
108Protuberant abdomen (HP:0001538)2.07673282
109Postural instability (HP:0002172)2.07522940
110Intention tremor (HP:0002080)2.04970984
111Asymmetric septal hypertrophy (HP:0001670)2.04574355
112Bell-shaped thorax (HP:0001591)2.01696759
113Increased CSF protein (HP:0002922)2.00866011
114Increased cerebral lipofuscin (HP:0011813)2.00726456
115Inflammation of the large intestine (HP:0002037)2.00436512
116Exercise-induced myalgia (HP:0003738)2.00159044
117Peritonitis (HP:0002586)1.98768515
118Abnormality of fatty-acid metabolism (HP:0004359)1.98609326
119Focal segmental glomerulosclerosis (HP:0000097)1.98231927
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97495299
121Purpura (HP:0000979)1.96733677
122Colitis (HP:0002583)1.96664573
123Spastic paraparesis (HP:0002313)1.96562369
124Esophageal varix (HP:0002040)1.95511754
125Osteolytic defects of the phalanges of the hand (HP:0009771)1.94779376
126Osteolytic defects of the hand bones (HP:0009699)1.94779376
127Muscle fiber inclusion bodies (HP:0100299)1.94582101
128Hyperglycinuria (HP:0003108)1.94179349
129Dysostosis multiplex (HP:0000943)1.93568323
130Sensory axonal neuropathy (HP:0003390)1.92738710
131Abnormal platelet volume (HP:0011876)1.90998968
132Abnormality of the fingertips (HP:0001211)1.90639983
133Abnormality of glycolipid metabolism (HP:0010969)1.90494418
134Abnormality of liposaccharide metabolism (HP:0010968)1.90494418
135Abnormality of glycosphingolipid metabolism (HP:0004343)1.90494418
136Vertigo (HP:0002321)1.90472760
137Hepatocellular carcinoma (HP:0001402)1.90413129
138Hematochezia (HP:0002573)1.90205093
139Abnormality of skeletal muscle fiber size (HP:0012084)1.90086824
140Increased variability in muscle fiber diameter (HP:0003557)1.89711392
141Nemaline bodies (HP:0003798)1.88552176
142Gastrointestinal inflammation (HP:0004386)1.87394989
143Rickets (HP:0002748)1.87299754
144Prolonged neonatal jaundice (HP:0006579)1.85879657
145Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.85646216
146Disinhibition (HP:0000734)1.85328891
147Pulmonary embolism (HP:0002204)1.84612292
148Ileus (HP:0002595)1.84565119
149Abnormal auditory evoked potentials (HP:0006958)1.83803769
150Peripheral hypomyelination (HP:0007182)1.83757109
151Paraparesis (HP:0002385)1.83245613
152Supranuclear gaze palsy (HP:0000605)1.83200914
153Episodic fever (HP:0001954)1.82469755
154Frequent falls (HP:0002359)1.82312905
155Ventricular fibrillation (HP:0001663)1.82081777
156Abnormality of the middle phalanges of the toes (HP:0010183)1.82044922
157Cerebral hemorrhage (HP:0001342)1.81891162
158Sensorimotor neuropathy (HP:0007141)1.81569767
159Urticaria (HP:0001025)1.81193240
160Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79399198
161Autoamputation (HP:0001218)1.78925980
162Polycythemia (HP:0001901)1.78665251
163Synostosis involving the elbow (HP:0003938)1.78386030
164Humeroradial synostosis (HP:0003041)1.78386030
165Abnormality of the ischium (HP:0003174)1.78144327
166Glomerulonephritis (HP:0000099)1.77991997
167Infantile muscular hypotonia (HP:0008947)1.76798141
168Mitral stenosis (HP:0001718)1.76776932
169Aortic aneurysm (HP:0004942)1.76771787
170Increased circulating renin level (HP:0000848)1.76526095
171Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75687833
172Subaortic stenosis (HP:0001682)1.75605703
173Abnormality of the left ventricular outflow tract (HP:0011103)1.75605703
174Hypoplastic ischia (HP:0003175)1.75009158
175Recurrent viral infections (HP:0004429)1.74969523
176Glomerulosclerosis (HP:0000096)1.74905348
177Subacute progressive viral hepatitis (HP:0006572)1.74231344
178Bifid scrotum (HP:0000048)1.73715065
179Ankle clonus (HP:0011448)1.73647070
180Metabolic alkalosis (HP:0200114)1.73088534
181Alopecia of scalp (HP:0002293)1.71854621
182Abnormality of the endocardium (HP:0004306)1.69909228
183Osteomyelitis (HP:0002754)1.69247253
184Thick nail (HP:0001805)1.69207755
185Abnormality of the peritoneum (HP:0002585)1.68825599
186Abnormality of the periventricular white matter (HP:0002518)1.68245107
187Scanning speech (HP:0002168)1.67617963
188Foot dorsiflexor weakness (HP:0009027)1.66139959
189Hypoplasia of the iris (HP:0007676)1.64411227
190Abnormality of the Achilles tendon (HP:0005109)1.63769535
191Abnormal gallbladder morphology (HP:0012437)1.63383817
192Pancreatitis (HP:0001733)1.63249201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.59452611
2EPHB14.23759326
3RIPK43.52937468
4PRPF4B2.92799819
5OXSR12.88554362
6MET2.69076665
7FGFR22.57347695
8BLK2.46602957
9SIK12.31822520
10MAP2K32.20405592
11PKN12.09484633
12FES2.05371531
13TYK21.99975375
14PBK1.95269777
15LATS11.91501441
16WNK41.80408388
17BCR1.79687152
18ERBB41.72883946
19ZAP701.68537555
20SGK21.67612211
21MAP4K11.62491667
22BCKDK1.56005346
23CSNK1A1L1.55998163
24SGK31.54365153
25KSR21.52440509
26EPHA21.50787317
27MAPKAPK51.49162281
28TXK1.47750922
29TTN1.46217075
30WNK11.43168576
31DDR21.42241132
32FGFR31.42174018
33IRAK41.41085954
34TNK21.37712739
35MAP3K11.33833716
36FGFR41.32322511
37SYK1.30570902
38MST1R1.29352551
39BTK1.28863678
40PTK21.28266581
41HCK1.27871168
42NEK61.26801215
43MAPK121.24495798
44PAK31.20226044
45MAPK151.18354300
46MAP3K71.18142254
47TAOK31.17468533
48OBSCN1.16879906
49BMX1.16183837
50SGK2231.15459694
51SGK4941.15459694
52CAMK1D1.15107883
53PTK61.14287993
54JAK31.14100886
55TYRO31.13795115
56PDGFRB1.12695103
57ERN11.12627439
58NEK91.10761627
59TRPM71.09644650
60CSNK1G31.07716395
61PRKD11.06721670
62CSNK1G11.06578888
63TESK21.06234704
64PDK11.04998136
65FGR1.04706393
66IKBKE1.04418143
67BMPR21.03743209
68TRIB31.03342622
69PIK3CA1.03316438
70ROCK21.03262452
71IRAK21.03214191
72GRK61.02422938
73NTRK31.01284509
74NLK0.99555287
75GSK3A0.99487912
76ICK0.98233698
77INSRR0.96886301
78CAMK1G0.96495180
79IRAK10.96047839
80PIK3CG0.95940698
81ITK0.94807852
82CAMKK10.94068867
83CAMKK20.92855588
84CSK0.92519795
85YES10.91575078
86STK30.91003810
87PDGFRA0.90821286
88EPHA30.89963748
89TEC0.87788813
90MAP3K110.87019377
91MST40.86679158
92PDPK10.86576917
93CAMK2D0.84150524
94CDC42BPA0.83605615
95FER0.83064750
96LYN0.81581824
97CSF1R0.81314494
98PRKCQ0.79805525
99CSNK1G20.79028424
100AKT30.78869350
101PHKG20.77206887
102PHKG10.77206887
103DAPK20.76336444
104RET0.76029561
105SGK10.75936396
106STK110.75177391
107PAK20.74313355
108LCK0.74043015
109TGFBR20.73099329
110JAK10.72407221
111LIMK10.71681100
112CAMK2B0.71484804
113CAMK2G0.69991275
114MAP3K60.69974634
115MAP3K20.69920524
116ABL20.69637170
117PTK2B0.69587478
118CAMK40.69362044
119MAP2K40.68632894
120KIT0.68544044
121ERBB20.65528349
122MAP2K20.64419452
123MAPK70.63500918
124PRKD30.63219191
125PRKAA20.62670571
126DYRK1B0.62659901
127PRKCE0.62205524
128STK380.62049526
129CDK190.61895618
130DMPK0.61787169
131NTRK10.61558240
132INSR0.60493759
133PRKCH0.60383471
134HIPK20.59178253
135MOS0.58926469
136STK38L0.58580442
137MARK30.56105913
138ABL10.54748258
139CAMK10.54637876
140MTOR0.53514945
141ROCK10.52747403
142PRKD20.52684525
143MAP3K30.52486907
144NUAK10.52243727
145TIE10.51910661
146RIPK10.51246569
147TAOK10.50405339
148FYN0.49995719
149UHMK10.48296764
150TBK10.47645179
151MAP3K130.47580509
152JAK20.46314681
153ACVR1B0.46223166
154MAP3K140.44644276
155PAK60.44641712
156FGFR10.44215719
157MARK20.41491803
158CDK60.40425296

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.80771702
2Steroid biosynthesis_Homo sapiens_hsa001003.40052688
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.17687828
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.16907685
5Fatty acid elongation_Homo sapiens_hsa000622.78257025
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65444052
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36681450
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30763170
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30654213
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22827168
11Complement and coagulation cascades_Homo sapiens_hsa046102.21470679
12Butanoate metabolism_Homo sapiens_hsa006502.16959760
13Osteoclast differentiation_Homo sapiens_hsa043802.15950799
14Leishmaniasis_Homo sapiens_hsa051402.07117618
15Histidine metabolism_Homo sapiens_hsa003402.07013802
16Fatty acid degradation_Homo sapiens_hsa000712.05083633
17Fatty acid metabolism_Homo sapiens_hsa012122.01059165
18Arginine biosynthesis_Homo sapiens_hsa002201.95756022
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88982823
20Tryptophan metabolism_Homo sapiens_hsa003801.88841847
21Propanoate metabolism_Homo sapiens_hsa006401.87963040
22B cell receptor signaling pathway_Homo sapiens_hsa046621.85691917
23Sulfur metabolism_Homo sapiens_hsa009201.81523461
24Peroxisome_Homo sapiens_hsa041461.76209038
25PPAR signaling pathway_Homo sapiens_hsa033201.74806047
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74479074
27Staphylococcus aureus infection_Homo sapiens_hsa051501.69892870
28Vitamin B6 metabolism_Homo sapiens_hsa007501.64201837
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55996758
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.55660559
31Tuberculosis_Homo sapiens_hsa051521.54959455
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52228273
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51353306
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50674159
35Chemical carcinogenesis_Homo sapiens_hsa052041.49437092
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48311103
37beta-Alanine metabolism_Homo sapiens_hsa004101.46059062
38Retinol metabolism_Homo sapiens_hsa008301.44349687
39Platelet activation_Homo sapiens_hsa046111.36354622
40Acute myeloid leukemia_Homo sapiens_hsa052211.33892631
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33119687
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32308589
43Ether lipid metabolism_Homo sapiens_hsa005651.30601324
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26576860
45Non-small cell lung cancer_Homo sapiens_hsa052231.26560158
46Bile secretion_Homo sapiens_hsa049761.26068636
47Chemokine signaling pathway_Homo sapiens_hsa040621.25665366
48Caffeine metabolism_Homo sapiens_hsa002321.23734705
49T cell receptor signaling pathway_Homo sapiens_hsa046601.23436861
50Arginine and proline metabolism_Homo sapiens_hsa003301.22335405
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21926665
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.19578107
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19219501
54Toxoplasmosis_Homo sapiens_hsa051451.16743827
55Long-term potentiation_Homo sapiens_hsa047201.16487247
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13117983
57Tyrosine metabolism_Homo sapiens_hsa003501.11868933
58Neurotrophin signaling pathway_Homo sapiens_hsa047221.11799749
59GnRH signaling pathway_Homo sapiens_hsa049121.09992433
60ABC transporters_Homo sapiens_hsa020101.09241361
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08825505
62Chronic myeloid leukemia_Homo sapiens_hsa052201.08363739
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.08146226
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06954124
65VEGF signaling pathway_Homo sapiens_hsa043701.04258175
66Graft-versus-host disease_Homo sapiens_hsa053321.03841532
67Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03497431
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03360506
69Jak-STAT signaling pathway_Homo sapiens_hsa046301.02973220
70Fatty acid biosynthesis_Homo sapiens_hsa000611.00987169
71TNF signaling pathway_Homo sapiens_hsa046680.99808737
72Pancreatic cancer_Homo sapiens_hsa052120.99045186
73Vitamin digestion and absorption_Homo sapiens_hsa049770.98488041
74Influenza A_Homo sapiens_hsa051640.96312924
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95744248
76Allograft rejection_Homo sapiens_hsa053300.95216545
77Hematopoietic cell lineage_Homo sapiens_hsa046400.94158103
78Choline metabolism in cancer_Homo sapiens_hsa052310.92909179
79Prolactin signaling pathway_Homo sapiens_hsa049170.92644680
80FoxO signaling pathway_Homo sapiens_hsa040680.92617294
81Endometrial cancer_Homo sapiens_hsa052130.92265698
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91626284
83Measles_Homo sapiens_hsa051620.90886450
84Inositol phosphate metabolism_Homo sapiens_hsa005620.90554737
85Glioma_Homo sapiens_hsa052140.89544806
86Phenylalanine metabolism_Homo sapiens_hsa003600.89542893
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87813869
88Pyruvate metabolism_Homo sapiens_hsa006200.85954707
89ErbB signaling pathway_Homo sapiens_hsa040120.85738358
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.85362518
91Fat digestion and absorption_Homo sapiens_hsa049750.85274786
92Starch and sucrose metabolism_Homo sapiens_hsa005000.84622857
93Renin secretion_Homo sapiens_hsa049240.84160150
94Pertussis_Homo sapiens_hsa051330.83817607
95Hepatitis C_Homo sapiens_hsa051600.83758049
96Selenocompound metabolism_Homo sapiens_hsa004500.83559965
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82779726
98Estrogen signaling pathway_Homo sapiens_hsa049150.82250317
99Folate biosynthesis_Homo sapiens_hsa007900.81591878
100Hepatitis B_Homo sapiens_hsa051610.80164421
101mTOR signaling pathway_Homo sapiens_hsa041500.79518483
102Lysosome_Homo sapiens_hsa041420.78877945
103Oxytocin signaling pathway_Homo sapiens_hsa049210.78451043
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77766258
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.77006923
106MAPK signaling pathway_Homo sapiens_hsa040100.76995604
107Glycerolipid metabolism_Homo sapiens_hsa005610.76870325
108Lysine degradation_Homo sapiens_hsa003100.75955377
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.74610732
110Notch signaling pathway_Homo sapiens_hsa043300.74006649
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73682798
112Gastric acid secretion_Homo sapiens_hsa049710.73544118
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72871400
114Insulin signaling pathway_Homo sapiens_hsa049100.72812208
115ECM-receptor interaction_Homo sapiens_hsa045120.72804697
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69522620
117Endocytosis_Homo sapiens_hsa041440.69440807
118Legionellosis_Homo sapiens_hsa051340.69067316
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68754032
120Sphingolipid metabolism_Homo sapiens_hsa006000.68728608
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68649980
122Linoleic acid metabolism_Homo sapiens_hsa005910.67774420
123Viral myocarditis_Homo sapiens_hsa054160.67735691
124Rap1 signaling pathway_Homo sapiens_hsa040150.66595669
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65403661
126Cholinergic synapse_Homo sapiens_hsa047250.64174953
127Type II diabetes mellitus_Homo sapiens_hsa049300.64114254
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63875200
129cAMP signaling pathway_Homo sapiens_hsa040240.62952108
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.61783848
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61411870
132Glutathione metabolism_Homo sapiens_hsa004800.61176155
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60331548
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60166925
135Type I diabetes mellitus_Homo sapiens_hsa049400.59968462
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58298359
137Ras signaling pathway_Homo sapiens_hsa040140.58275702
138African trypanosomiasis_Homo sapiens_hsa051430.57992658
139HIF-1 signaling pathway_Homo sapiens_hsa040660.57652162
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56094250
141Asthma_Homo sapiens_hsa053100.54145099
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53467594
143Prion diseases_Homo sapiens_hsa050200.50754834
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.47686432
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.47455666
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.47077836
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46130995
148Autoimmune thyroid disease_Homo sapiens_hsa053200.39387610
149Malaria_Homo sapiens_hsa051440.38572499
150Carbon metabolism_Homo sapiens_hsa012000.36989246
151Biosynthesis of amino acids_Homo sapiens_hsa012300.36605112
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.35994278
153Axon guidance_Homo sapiens_hsa043600.35322114
154Mineral absorption_Homo sapiens_hsa049780.34955181
155Focal adhesion_Homo sapiens_hsa045100.34194426
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34063294
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.33310658
158Renal cell carcinoma_Homo sapiens_hsa052110.33104182
159Amoebiasis_Homo sapiens_hsa051460.31555683
1602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31267551
161Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30651549
162Insulin resistance_Homo sapiens_hsa049310.30574527
163Ovarian steroidogenesis_Homo sapiens_hsa049130.29815915
164Metabolic pathways_Homo sapiens_hsa011000.28044704
165Tight junction_Homo sapiens_hsa045300.26794593
166Cyanoamino acid metabolism_Homo sapiens_hsa004600.24754431
167Other glycan degradation_Homo sapiens_hsa005110.22834818
168Protein digestion and absorption_Homo sapiens_hsa049740.20142929
169Dorso-ventral axis formation_Homo sapiens_hsa043200.19499146
170Phagosome_Homo sapiens_hsa041450.17870718
171Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16778732
172Arachidonic acid metabolism_Homo sapiens_hsa005900.15837149
173Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15034571
174PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14027081
175Proteoglycans in cancer_Homo sapiens_hsa052050.13932474
176AMPK signaling pathway_Homo sapiens_hsa041520.13910592
177Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12783519
178Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12685890
179Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.12284417
180Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11717836
181Prostate cancer_Homo sapiens_hsa052150.09822111

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