MTMR12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.57113200
2positive regulation of gamma-delta T cell activation (GO:0046645)4.46543884
3negative T cell selection (GO:0043383)4.15976654
4negative thymic T cell selection (GO:0045060)4.04092274
5regulation of gamma-delta T cell differentiation (GO:0045586)3.85721095
6interferon-gamma production (GO:0032609)3.83529283
7nuclear pore complex assembly (GO:0051292)3.83486213
8negative regulation of cell killing (GO:0031342)3.82028191
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.82028191
10NIK/NF-kappaB signaling (GO:0038061)3.80705935
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.65477309
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.65477309
13regulation of gamma-delta T cell activation (GO:0046643)3.63902769
14antigen processing and presentation of endogenous antigen (GO:0019883)3.61460800
15regulation of interleukin-12 biosynthetic process (GO:0045075)3.50090180
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46621684
17T cell selection (GO:0045058)3.44972203
18regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.43892109
19nuclear pore organization (GO:0006999)3.40773188
20thymic T cell selection (GO:0045061)3.39251342
21NLS-bearing protein import into nucleus (GO:0006607)3.37190397
22positive thymic T cell selection (GO:0045059)3.36314375
23regulation of B cell receptor signaling pathway (GO:0050855)3.34507917
24positive T cell selection (GO:0043368)3.25272630
25cytoplasmic mRNA processing body assembly (GO:0033962)3.22723230
26response to interleukin-15 (GO:0070672)3.12569177
27proline biosynthetic process (GO:0006561)3.12174221
28mitotic sister chromatid cohesion (GO:0007064)3.10208409
29protein localization to microtubule (GO:0035372)3.07464361
30angiogenesis involved in wound healing (GO:0060055)3.07372587
31cellular response to interleukin-15 (GO:0071350)3.06961227
32protein localization to kinetochore (GO:0034501)3.06602236
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.04909029
34epithelial cell-cell adhesion (GO:0090136)3.04869987
35hippo signaling (GO:0035329)3.03779011
36natural killer cell mediated immunity (GO:0002228)3.03052838
37natural killer cell mediated cytotoxicity (GO:0042267)3.03052838
38histone H3-K36 demethylation (GO:0070544)3.01681019
39positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.01643463
40regulation of B cell differentiation (GO:0045577)3.01547593
41pore complex assembly (GO:0046931)3.01457238
42leukocyte aggregation (GO:0070486)3.00754192
43blood coagulation, intrinsic pathway (GO:0007597)2.98661307
44hypotonic response (GO:0006971)2.97718552
45interferon-gamma secretion (GO:0072643)2.96757247
46iron ion import (GO:0097286)2.96526856
47regulation of response to tumor cell (GO:0002834)2.95330017
48positive regulation of response to tumor cell (GO:0002836)2.95330017
49positive regulation of immune response to tumor cell (GO:0002839)2.95330017
50regulation of immune response to tumor cell (GO:0002837)2.95330017
51thrombin receptor signaling pathway (GO:0070493)2.94718594
52myeloid dendritic cell activation (GO:0001773)2.88888144
53DNA unwinding involved in DNA replication (GO:0006268)2.87764006
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87605585
55establishment of endothelial barrier (GO:0061028)2.86040575
56antigen processing and presentation via MHC class Ib (GO:0002475)2.82693157
57myeloid dendritic cell differentiation (GO:0043011)2.81008829
58megakaryocyte development (GO:0035855)2.80172513
59regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.77790594
60protein complex localization (GO:0031503)2.75483385
61regulation of RNA export from nucleus (GO:0046831)2.75236131
62regulation of T cell tolerance induction (GO:0002664)2.74886511
63protein localization to chromosome, centromeric region (GO:0071459)2.74673868
64positive regulation of protein import into nucleus, translocation (GO:0033160)2.72579007
65regulation of stem cell maintenance (GO:2000036)2.70599165
66negative regulation of DNA repair (GO:0045738)2.70050737
67regulation of T cell receptor signaling pathway (GO:0050856)2.70049071
68signal complex assembly (GO:0007172)2.69790021
69natural killer cell differentiation (GO:0001779)2.69758526
70mesodermal cell differentiation (GO:0048333)2.68980658
71regulation of histone H3-K27 methylation (GO:0061085)2.68958323
72phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.68279894
73positive regulation of interleukin-2 production (GO:0032743)2.67395956
74negative regulation of protein localization to plasma membrane (GO:1903077)2.67150029
75phosphate ion transmembrane transport (GO:0035435)2.66961391
76positive regulation of endothelial cell apoptotic process (GO:2000353)2.65464301
77regulation of integrin activation (GO:0033623)2.64205114
78T cell costimulation (GO:0031295)2.63395592
79positive regulation of hormone biosynthetic process (GO:0046886)2.63141793
80regulation of Golgi to plasma membrane protein transport (GO:0042996)2.62686444
81B cell receptor signaling pathway (GO:0050853)2.62280898
82positive regulation of SMAD protein import into nucleus (GO:0060391)2.61740401
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.61604121
84response to muramyl dipeptide (GO:0032495)2.61238504
85cellular protein complex localization (GO:0034629)2.61109046
86embryonic process involved in female pregnancy (GO:0060136)2.61043141
87regulation of histone H3-K4 methylation (GO:0051569)2.60428998
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60331624
89corticosteroid receptor signaling pathway (GO:0031958)2.58965990
90lymphocyte costimulation (GO:0031294)2.58961435
91desmosome organization (GO:0002934)2.58304301
92T cell receptor signaling pathway (GO:0050852)2.58115709
93positive regulation of hormone metabolic process (GO:0032352)2.57960972
94focal adhesion assembly (GO:0048041)2.57919759
95cell-substrate adherens junction assembly (GO:0007045)2.57919759
96adherens junction assembly (GO:0034333)2.57619204
97negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.57142070
98regulation of early endosome to late endosome transport (GO:2000641)2.56917896
99ovulation from ovarian follicle (GO:0001542)2.56750679
100natural killer cell activation (GO:0030101)2.56518243
101endothelium development (GO:0003158)2.56057976
102CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.54956238
103T-helper cell differentiation (GO:0042093)2.54956238
104meiotic chromosome segregation (GO:0045132)2.54664061
105Golgi transport vesicle coating (GO:0048200)2.53728211
106COPI coating of Golgi vesicle (GO:0048205)2.53728211
107DNA duplex unwinding (GO:0032508)2.53517320
108positive regulation of B cell differentiation (GO:0045579)2.52759915
109alpha-beta T cell activation (GO:0046631)2.52384756
110antigen receptor-mediated signaling pathway (GO:0050851)2.52051754
111hepatocyte apoptotic process (GO:0097284)2.51519179
112positive regulation of histone deacetylation (GO:0031065)2.51277862
113JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.51220096
114regulation of integrin-mediated signaling pathway (GO:2001044)2.51125531
115leukocyte cell-cell adhesion (GO:0007159)2.50734634
116regulation of DNA endoreduplication (GO:0032875)2.50516377
117COPII vesicle coating (GO:0048208)2.48844738
118pre-miRNA processing (GO:0031054)2.46683159
119positive regulation of lamellipodium assembly (GO:0010592)2.46126528
120modulation by symbiont of host cellular process (GO:0044068)2.45711322
121mitotic nuclear envelope disassembly (GO:0007077)2.45640869
122cell-substrate junction assembly (GO:0007044)2.45283724
123T cell migration (GO:0072678)2.45226983
124tolerance induction (GO:0002507)2.44991968
125nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.42721674
126bundle of His cell to Purkinje myocyte communication (GO:0086069)2.42182720
127positive regulation of macroautophagy (GO:0016239)2.41395790
128neutrophil activation (GO:0042119)2.40273273
129cellular response to epidermal growth factor stimulus (GO:0071364)2.40257416
130positive regulation of cellular response to insulin stimulus (GO:1900078)2.40175683
131regulation of platelet aggregation (GO:0090330)2.39484447
132positive regulation of chromosome segregation (GO:0051984)2.39073492
133negative regulation of homotypic cell-cell adhesion (GO:0034111)2.38998664
134mitotic chromosome condensation (GO:0007076)2.38777578
135regulation of nucleobase-containing compound transport (GO:0032239)2.38770969
136sister chromatid segregation (GO:0000819)2.38188612
137protein export from nucleus (GO:0006611)2.38074570
138positive regulation of mRNA catabolic process (GO:0061014)2.37890686
139growth hormone receptor signaling pathway (GO:0060396)2.37801352
140DNA geometric change (GO:0032392)2.37552340
141dendritic cell differentiation (GO:0097028)2.37348366
142negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.36848066
143nuclear envelope disassembly (GO:0051081)2.36706435
144membrane disassembly (GO:0030397)2.36706435
145regulation of alpha-beta T cell proliferation (GO:0046640)2.36199500
146interferon-gamma-mediated signaling pathway (GO:0060333)2.35886053
147vesicle coating (GO:0006901)2.35864996
148trophectodermal cell differentiation (GO:0001829)2.35229447
149low-density lipoprotein particle clearance (GO:0034383)2.35133681
150positive regulation of isotype switching (GO:0045830)2.35057930
151regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.34862137
152regulation of chromatin binding (GO:0035561)2.34166276
153germinal center formation (GO:0002467)2.34107962
154alpha-beta T cell differentiation involved in immune response (GO:0002293)2.33252729
155alpha-beta T cell activation involved in immune response (GO:0002287)2.33252729
156T cell differentiation involved in immune response (GO:0002292)2.33252729
157alpha-beta T cell differentiation (GO:0046632)2.32926205
158regulation of transforming growth factor beta2 production (GO:0032909)2.31529221
159regulation of establishment of cell polarity (GO:2000114)2.31516875
160L-alpha-amino acid transmembrane transport (GO:1902475)2.31354614
161negative regulation of T cell receptor signaling pathway (GO:0050860)2.31202350
162response to epidermal growth factor (GO:0070849)2.30964700
163spliceosomal tri-snRNP complex assembly (GO:0000244)2.30306623
164mRNA transcription from RNA polymerase II promoter (GO:0042789)2.30141150
165protein destabilization (GO:0031648)2.29584399
166regulation of response to interferon-gamma (GO:0060330)2.29269739
167regulation of histone methylation (GO:0031060)2.28225642
168regulation of glucose import in response to insulin stimulus (GO:2001273)2.28132011
169cytoskeletal anchoring at plasma membrane (GO:0007016)2.27947514
170intestinal epithelial cell development (GO:0060576)2.27738876
171tight junction assembly (GO:0070830)2.27407967
172SMAD protein complex assembly (GO:0007183)2.27253343
173mitotic sister chromatid segregation (GO:0000070)2.26541833
174insulin-like growth factor receptor signaling pathway (GO:0048009)2.25962197
175long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.25731742
176regulation of interleukin-2 biosynthetic process (GO:0045076)2.25345529
177regulation of necroptotic process (GO:0060544)2.24805998
178granulocyte activation (GO:0036230)2.24493086
179negative regulation of histone methylation (GO:0031061)2.24349010
180tyrosine phosphorylation of STAT protein (GO:0007260)2.24103826
181regulation of histone H3-K9 methylation (GO:0051570)2.23569170
182cellular response to zinc ion (GO:0071294)2.22950043
183negative regulation of histone modification (GO:0031057)2.21498502
184platelet aggregation (GO:0070527)2.21419248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.28467812
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.11862795
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.99574897
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.59057780
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.69921819
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.68266879
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.68181959
8GATA1_22025678_ChIP-Seq_K562_Human3.37121703
9MYC_22102868_ChIP-Seq_BL_Human3.22461826
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.91972498
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.85296100
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.77636505
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.54449938
14RUNX_20019798_ChIP-Seq_JUKART_Human2.52216825
15* MYB_26560356_Chip-Seq_TH2_Human2.44713845
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42901228
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.37713136
18* TCF7_22412390_ChIP-Seq_EML_Mouse2.28910301
19MYB_26560356_Chip-Seq_TH1_Human2.25717822
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.25598146
21MAF_26560356_Chip-Seq_TH1_Human2.22056829
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.21308871
23SCL_19346495_ChIP-Seq_HPC-7_Human2.15804977
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15614344
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10750517
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.09786213
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06930082
28ZNF217_24962896_ChIP-Seq_MCF-7_Human2.05384998
29STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05208430
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05131242
31E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03074611
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03026415
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97691085
34VDR_21846776_ChIP-Seq_THP-1_Human1.96771448
35CLOCK_20551151_ChIP-Seq_293T_Human1.91220175
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90237842
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90221045
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.90128538
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.90128538
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.90128538
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.86480436
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83057865
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.79752546
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.78555913
45UTX_26944678_Chip-Seq_JUKART_Human1.75812175
46* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75629913
47* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.75477547
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.74489537
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72382621
50CHD1_26751641_Chip-Seq_LNCaP_Human1.71711737
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.69932943
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.67314730
53SPI1_23127762_ChIP-Seq_K562_Human1.64384777
54ZNF263_19887448_ChIP-Seq_K562_Human1.63032332
55* RUNX1_22412390_ChIP-Seq_EML_Mouse1.62750848
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61073048
57* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59620727
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56698807
59KDM2B_26808549_Chip-Seq_DND41_Human1.55255682
60VDR_24763502_ChIP-Seq_THP-1_Human1.51143831
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.49773263
62* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49269732
63SPI1_23547873_ChIP-Seq_NB4_Human1.48479569
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47092713
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46383801
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45505574
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43387619
68* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42625395
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.38496071
70* LXR_22158963_ChIP-Seq_LIVER_Mouse1.37870609
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37393836
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35659111
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32519057
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32155899
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32123253
76GATA1_19941826_ChIP-Seq_K562_Human1.29178862
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28667937
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27274854
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26892318
80GATA3_27048872_Chip-Seq_THYMUS_Human1.24947317
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23578991
82* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23523329
83* GATA2_19941826_ChIP-Seq_K562_Human1.21631961
84* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18939458
85* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18484288
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17964561
87FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17361608
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15790432
89* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15111284
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15041301
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.14786383
92* PU_27001747_Chip-Seq_BMDM_Mouse1.14781865
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14573591
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.13193910
95* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12878985
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12809257
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11468413
98MAF_26560356_Chip-Seq_TH2_Human1.10312365
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.10064255
100AHR_22903824_ChIP-Seq_MCF-7_Human1.10063050
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09948775
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09893026
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09653603
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07894394
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07202217
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07175510
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06369933
108FOXO3_23340844_ChIP-Seq_DLD1_Human1.06042698
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03743560
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02505692
111PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02102355
112HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02065707
113* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01880664
114* RXR_22158963_ChIP-Seq_LIVER_Mouse1.01765787
115FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00700348
116ATF3_27146783_Chip-Seq_COLON_Human1.00681541
117GATA3_24758297_ChIP-Seq_MCF-7_Human1.00374713
118SOX2_20726797_ChIP-Seq_SW620_Human0.99015407
119* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98177793
120VDR_24787735_ChIP-Seq_THP-1_Human0.98064225
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97391854
122RACK7_27058665_Chip-Seq_MCF-7_Human0.95112067
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.94987362
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.94354137
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.94272280
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94245057
127NCOR1_26117541_ChIP-Seq_K562_Human0.93295519
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93007717
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92356690
130* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92139383
131* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92096090
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.91309665
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90572246
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89940557
135MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89721519
136TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89301705
137ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87023673
138* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86198235
139GATA3_26560356_Chip-Seq_TH2_Human0.83933241
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83863921
141TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82844970
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82515882
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82105546
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82105546
145MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81783205
146GATA1_19941827_ChIP-Seq_MEL_Mouse0.80854399
147RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80020972
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79467635
149TFEB_21752829_ChIP-Seq_HELA_Human0.79180505
150AR_21909140_ChIP-Seq_LNCAP_Human0.78420037
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77704554
152CIITA_25753668_ChIP-Seq_RAJI_Human0.77382923
153ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.76388289
154RUNX1_27514584_Chip-Seq_MCF-7_Human0.74789380
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.74473018
156FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74191130
157PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73722464
158TP63_19390658_ChIP-ChIP_HaCaT_Human0.73317959
159GATA6_25053715_ChIP-Seq_YYC3_Human0.72966679
160GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72909790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.03434870
2MP0003763_abnormal_thymus_physiology2.95035565
3MP0000685_abnormal_immune_system2.89469143
4MP0004185_abnormal_adipocyte_glucose2.74280995
5MP0001790_abnormal_immune_system2.59297170
6MP0005387_immune_system_phenotype2.59297170
7MP0005409_darkened_coat_color2.52971125
8MP0005671_abnormal_response_to2.51388915
9MP0004510_myositis2.45901107
10MP0002396_abnormal_hematopoietic_system2.45793812
11MP0001800_abnormal_humoral_immune2.42064577
12MP0008057_abnormal_DNA_replication2.34409958
13MP0002166_altered_tumor_susceptibility2.28665940
14MP0010352_gastrointestinal_tract_polyps2.27092201
15MP0002398_abnormal_bone_marrow2.23542302
16MP0004808_abnormal_hematopoietic_stem2.21172850
17MP0002452_abnormal_antigen_presenting2.17497353
18MP0002420_abnormal_adaptive_immunity2.13576606
19MP0001819_abnormal_immune_cell2.13154941
20MP0002723_abnormal_immune_serum2.10161365
21MP0002006_tumorigenesis2.09488491
22MP0005076_abnormal_cell_differentiation2.06000491
23MP0005000_abnormal_immune_tolerance2.03742217
24MP0010678_abnormal_skin_adnexa2.01892838
25MP0001873_stomach_inflammation2.00603184
26MP0008877_abnormal_DNA_methylation2.00240788
27MP0009785_altered_susceptibility_to1.95784519
28MP0005666_abnormal_adipose_tissue1.93768222
29MP0010094_abnormal_chromosome_stability1.93104017
30MP0003436_decreased_susceptibility_to1.92842416
31MP0000703_abnormal_thymus_morphology1.92653114
32MP0009780_abnormal_chondrocyte_physiolo1.92524555
33MP0004947_skin_inflammation1.91668818
34MP0004272_abnormal_basement_membrane1.91253660
35MP0000716_abnormal_immune_system1.87768811
36MP0000569_abnormal_digit_pigmentation1.87525891
37MP0001730_embryonic_growth_arrest1.84093165
38MP0002254_reproductive_system_inflammat1.82451323
39MP0005397_hematopoietic_system_phenotyp1.80959947
40MP0001545_abnormal_hematopoietic_system1.80959947
41MP0002796_impaired_skin_barrier1.80013704
42MP0002405_respiratory_system_inflammati1.79846355
43MP0009278_abnormal_bone_marrow1.77554717
44MP0010307_abnormal_tumor_latency1.76650363
45MP0002722_abnormal_immune_system1.74603098
46MP0000383_abnormal_hair_follicle1.73539499
47MP0010234_abnormal_vibrissa_follicle1.72969971
48MP0010155_abnormal_intestine_physiology1.71794544
49MP0003303_peritoneal_inflammation1.71690315
50MP0002009_preneoplasia1.70926372
51MP0000689_abnormal_spleen_morphology1.70021967
52MP0003300_gastrointestinal_ulcer1.68925773
53MP0003941_abnormal_skin_development1.65172809
54MP0005310_abnormal_salivary_gland1.63943998
55MP0003111_abnormal_nucleus_morphology1.63337316
56MP0001915_intracranial_hemorrhage1.61358214
57MP0002429_abnormal_blood_cell1.60731828
58MP0005025_abnormal_response_to1.59939311
59MP0005451_abnormal_body_composition1.55620210
60MP0002138_abnormal_hepatobiliary_system1.54743444
61MP0000490_abnormal_crypts_of1.53849570
62MP0001661_extended_life_span1.51872727
63MP0004264_abnormal_extraembryonic_tissu1.51860969
64MP0002148_abnormal_hypersensitivity_rea1.51580238
65MP0002419_abnormal_innate_immunity1.50497484
66MP0003077_abnormal_cell_cycle1.49762355
67MP0008004_abnormal_stomach_pH1.47196692
68MP0010368_abnormal_lymphatic_system1.41904581
69MP0002877_abnormal_melanocyte_morpholog1.39578464
70MP0008007_abnormal_cellular_replicative1.38848913
71MP0005501_abnormal_skin_physiology1.37018958
72MP0005174_abnormal_tail_pigmentation1.36353715
73MP0001879_abnormal_lymphatic_vessel1.36190914
74MP0003448_altered_tumor_morphology1.35644059
75MP0003890_abnormal_embryonic-extraembry1.33763784
76MP0003943_abnormal_hepatobiliary_system1.33433952
77MP0001697_abnormal_embryo_size1.30474375
78MP0005083_abnormal_biliary_tract1.29957674
79MP0003950_abnormal_plasma_membrane1.28749870
80MP0009672_abnormal_birth_weight1.26520718
81MP0003453_abnormal_keratinocyte_physiol1.26283369
82MP0000858_altered_metastatic_potential1.25616276
83MP0003566_abnormal_cell_adhesion1.24857443
84MP0003656_abnormal_erythrocyte_physiolo1.24528641
85MP0009333_abnormal_splenocyte_physiolog1.24065766
86MP0005375_adipose_tissue_phenotype1.23877313
87MP0001845_abnormal_inflammatory_respons1.21605951
88MP0009703_decreased_birth_body1.20662703
89MP0009697_abnormal_copulation1.20182080
90MP0006082_CNS_inflammation1.19510109
91MP0003868_abnormal_feces_composition1.17052604
92MP0002080_prenatal_lethality1.15900304
93MP0004233_abnormal_muscle_weight1.15713159
94MP0005464_abnormal_platelet_physiology1.15445521
95MP0002019_abnormal_tumor_incidence1.13738299
96MP0000015_abnormal_ear_pigmentation1.12542469
97MP0004957_abnormal_blastocyst_morpholog1.10239082
98MP0005408_hypopigmentation1.09624612
99MP0000350_abnormal_cell_proliferation1.08823881
100MP0002084_abnormal_developmental_patter1.08468301
101MP0005023_abnormal_wound_healing1.07347930
102MP0001849_ear_inflammation1.06831527
103MP0000377_abnormal_hair_follicle1.06443372
104MP0002086_abnormal_extraembryonic_tissu1.05886330
105MP0008260_abnormal_autophagy1.05712234
106MP0006138_congestive_heart_failure1.05681136
107MP0000627_abnormal_mammary_gland1.03293034
108MP0008932_abnormal_embryonic_tissue1.02863658
109MP0003172_abnormal_lysosome_physiology1.01798791
110MP0004084_abnormal_cardiac_muscle0.98211023
111MP0003091_abnormal_cell_migration0.98111261
112MP0003866_abnormal_defecation0.96676163
113MP0003705_abnormal_hypodermis_morpholog0.95484190
114MP0001853_heart_inflammation0.95419740
115MP0001851_eye_inflammation0.95189229
116MP0005384_cellular_phenotype0.95141658
117MP0002085_abnormal_embryonic_tissue0.94388666
118MP0003045_fibrosis0.94139544
119MP0005367_renal/urinary_system_phenotyp0.93963330
120MP0000516_abnormal_urinary_system0.93963330
121MP0003724_increased_susceptibility_to0.89983754
122MP0000598_abnormal_liver_morphology0.88512950
123MP0008961_abnormal_basal_metabolism0.88180166
124MP0002933_joint_inflammation0.86406823
125MP0003693_abnormal_embryo_hatching0.86331213
126MP0002277_abnormal_respiratory_mucosa0.86037221
127MP0003984_embryonic_growth_retardation0.85925799
128MP0002925_abnormal_cardiovascular_devel0.85785654
129MP0003183_abnormal_peptide_metabolism0.85242061
130MP0002088_abnormal_embryonic_growth/wei0.84929227
131MP0004197_abnormal_fetal_growth/weight/0.84662369
132MP0000537_abnormal_urethra_morphology0.84375968
133MP0003787_abnormal_imprinting0.84152748
134MP0008058_abnormal_DNA_repair0.83696719
135MP0003191_abnormal_cellular_cholesterol0.83065023
136MP0000371_diluted_coat_color0.83017987
137MP0000313_abnormal_cell_death0.80539788
138MP0010630_abnormal_cardiac_muscle0.80534317
139MP0003828_pulmonary_edema0.80305118
140MP0004130_abnormal_muscle_cell0.78796679
141MP0000465_gastrointestinal_hemorrhage0.78207524
142MP0004036_abnormal_muscle_relaxation0.78093621
143MP0001672_abnormal_embryogenesis/_devel0.77662754
144MP0005380_embryogenesis_phenotype0.77662754
145MP0000003_abnormal_adipose_tissue0.76435698
146MP0002998_abnormal_bone_remodeling0.75438049
147MP0002928_abnormal_bile_duct0.74648485
148MP0000767_abnormal_smooth_muscle0.74522587
149MP0001348_abnormal_lacrimal_gland0.73864650
150MP0001191_abnormal_skin_condition0.72692638
151MP0002128_abnormal_blood_circulation0.72239922
152MP0005621_abnormal_cell_physiology0.72213570
153MP0001216_abnormal_epidermal_layer0.72066482
154MP0002095_abnormal_skin_pigmentation0.71151295
155MP0005220_abnormal_exocrine_pancreas0.71081507
156MP0001614_abnormal_blood_vessel0.68608229
157MP0000609_abnormal_liver_physiology0.67299453
158MP0002098_abnormal_vibrissa_morphology0.67105893
159MP0001784_abnormal_fluid_regulation0.66356130
160MP0010329_abnormal_lipoprotein_level0.65853018
161MP0000467_abnormal_esophagus_morphology0.65481609

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)5.53503741
2Menorrhagia (HP:0000132)5.15134347
3Abnormal platelet volume (HP:0011876)5.02070800
4Prolonged bleeding time (HP:0003010)4.67726491
5Recurrent viral infections (HP:0004429)3.59779891
6Recurrent fungal infections (HP:0002841)3.50786580
7Sparse lateral eyebrow (HP:0005338)3.46949520
8Dysmetric saccades (HP:0000641)3.46838215
9Chronic otitis media (HP:0000389)3.37971437
10Abnormality of T cell number (HP:0011839)3.31783138
11Abnormality of the fingertips (HP:0001211)3.30521771
12T lymphocytopenia (HP:0005403)3.29769970
13Papillary thyroid carcinoma (HP:0002895)3.18424504
14Termporal pattern (HP:0011008)3.18394507
15Insidious onset (HP:0003587)3.18394507
16Panhypogammaglobulinemia (HP:0003139)3.12271282
17Flat acetabular roof (HP:0003180)3.07171276
18Nasal polyposis (HP:0100582)3.06814260
19Deep philtrum (HP:0002002)3.05630352
20Thyroiditis (HP:0100646)2.93241725
21Eczematoid dermatitis (HP:0000976)2.92469777
22Volvulus (HP:0002580)2.91868744
23Combined immunodeficiency (HP:0005387)2.84067045
24Recurrent bronchitis (HP:0002837)2.81838189
25Impaired platelet aggregation (HP:0003540)2.81666647
26Abnormal platelet function (HP:0011869)2.81666647
27Epistaxis (HP:0000421)2.81277372
28Purpura (HP:0000979)2.80582751
29Asymmetry of the thorax (HP:0001555)2.79912812
30Myositis (HP:0100614)2.79613470
31Severe combined immunodeficiency (HP:0004430)2.74105439
32Elevated erythrocyte sedimentation rate (HP:0003565)2.74069730
33Myocardial infarction (HP:0001658)2.69948670
34Abnormality of the common coagulation pathway (HP:0010990)2.67335813
35Gingival bleeding (HP:0000225)2.65158360
36Recurrent abscess formation (HP:0002722)2.65084840
37Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.64461532
38Abnormality of T cells (HP:0002843)2.63023803
39Abnormality of the nasal mucosa (HP:0000433)2.62249555
40Orchitis (HP:0100796)2.60304563
41Autoimmune thrombocytopenia (HP:0001973)2.60001557
42Optic neuritis (HP:0100653)2.58694701
43Retrobulbar optic neuritis (HP:0100654)2.58694701
44Mediastinal lymphadenopathy (HP:0100721)2.57773255
45B lymphocytopenia (HP:0010976)2.52345391
46Abnormality of B cell number (HP:0010975)2.52345391
47Petechiae (HP:0000967)2.50380845
48IgM deficiency (HP:0002850)2.45509143
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.44101231
50Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.41173894
51Eosinophilia (HP:0001880)2.35010955
52IgG deficiency (HP:0004315)2.34894721
53Leiomyosarcoma (HP:0100243)2.32371900
54Uterine leiomyosarcoma (HP:0002891)2.32371900
55Chronic mucocutaneous candidiasis (HP:0002728)2.31469385
56Recurrent cutaneous fungal infections (HP:0011370)2.31469385
57Increased IgE level (HP:0003212)2.30270930
58Recurrent bacterial skin infections (HP:0005406)2.30193483
59Acanthocytosis (HP:0001927)2.28982742
60Back pain (HP:0003418)2.28369060
61Arterial thrombosis (HP:0004420)2.27476282
62Broad palm (HP:0001169)2.26002327
63Transitional cell carcinoma of the bladder (HP:0006740)2.25150159
64Vasculitis (HP:0002633)2.21806660
65Curly hair (HP:0002212)2.21527643
66Abnormality of eosinophils (HP:0001879)2.19843503
67Acute myeloid leukemia (HP:0004808)2.18576358
68Stomatitis (HP:0010280)2.17498066
69Renal cell carcinoma (HP:0005584)2.15827860
70Deep venous thrombosis (HP:0002625)2.14961708
71Gastrointestinal carcinoma (HP:0002672)2.14880539
72Malignant gastrointestinal tract tumors (HP:0006749)2.14880539
73Leukocytosis (HP:0001974)2.14014196
74Tetraparesis (HP:0002273)2.13708075
75Amaurosis fugax (HP:0100576)2.12250729
76Ankyloglossia (HP:0010296)2.11743207
77Basal cell carcinoma (HP:0002671)2.11235241
78Pustule (HP:0200039)2.10499388
79Subacute progressive viral hepatitis (HP:0006572)2.10330963
80Cellulitis (HP:0100658)2.08644820
81Hematochezia (HP:0002573)2.08376127
82Bilateral sensorineural hearing impairment (HP:0008619)2.07990104
83IgA deficiency (HP:0002720)2.07631479
84Absent frontal sinuses (HP:0002688)2.06943750
85Syringomyelia (HP:0003396)2.05648505
86Spinal cord lesions (HP:0100561)2.05648505
87Abnormality of T cell physiology (HP:0011840)2.05230549
88Pulmonary infiltrates (HP:0002113)2.04987633
89Periodontitis (HP:0000704)2.04557024
90Poikilocytosis (HP:0004447)2.04472093
91Dyschromatopsia (HP:0007641)2.03559420
92Ependymoma (HP:0002888)2.03298181
93Bladder carcinoma (HP:0002862)2.03276171
94Bladder neoplasm (HP:0009725)2.03276171
95Heterotopia (HP:0002282)2.03037403
96Skull defect (HP:0001362)2.01059464
97Short chin (HP:0000331)1.99889121
98Thyroid carcinoma (HP:0002890)1.99424535
99Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.99014628
100Agnosia (HP:0010524)1.98052775
101Abnormality of cells of the lymphoid lineage (HP:0012140)1.97231115
102Osteolytic defects of the hand bones (HP:0009699)1.97023758
103Osteolytic defects of the phalanges of the hand (HP:0009771)1.97023758
104Agammaglobulinemia (HP:0004432)1.95711167
105Deviation of the thumb (HP:0009603)1.95687852
106Right ventricular cardiomyopathy (HP:0011663)1.95436493
107Frequent falls (HP:0002359)1.95393741
108Abnormality of the epiphyses of the hand (HP:0005924)1.94642046
109Granulocytopenia (HP:0001913)1.93905487
110Capillary hemangiomas (HP:0005306)1.93561873
111Lymphoma (HP:0002665)1.92009327
112Meningitis (HP:0001287)1.90108934
113Keratoconjunctivitis sicca (HP:0001097)1.89880462
114High pitched voice (HP:0001620)1.89590797
115Overlapping toe (HP:0001845)1.89032771
116Abnormality of the prostate (HP:0008775)1.88969975
117Fatigue (HP:0012378)1.87530975
118Abnormal auditory evoked potentials (HP:0006958)1.87154928
119Lymphopenia (HP:0001888)1.86286325
120Fibular aplasia (HP:0002990)1.85880802
121Increased IgM level (HP:0003496)1.85525369
122Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.85390920
123Macroorchidism (HP:0000053)1.84508527
124Inflammation of the large intestine (HP:0002037)1.84039426
125Low anterior hairline (HP:0000294)1.83608067
126Chronic diarrhea (HP:0002028)1.83142508
127Lip pit (HP:0100267)1.83055625
128Myelodysplasia (HP:0002863)1.82043417
129Abnormality of the nasal septum (HP:0000419)1.81377187
130Chromsome breakage (HP:0040012)1.80893439
131Gastrointestinal inflammation (HP:0004386)1.79980107
132Hemoptysis (HP:0002105)1.79367299
133Keratoconjunctivitis (HP:0001096)1.79141845
134Gingivitis (HP:0000230)1.78951434
135Leukopenia (HP:0001882)1.78261878
136Prominent nose (HP:0000448)1.77699013
137Long eyelashes (HP:0000527)1.77165690
138Autoimmune hemolytic anemia (HP:0001890)1.76630043
139Chest pain (HP:0100749)1.76077467
140Abnormality of the lower motor neuron (HP:0002366)1.75206594
141Viral hepatitis (HP:0006562)1.74476457
142Colitis (HP:0002583)1.73636152
143Relative macrocephaly (HP:0004482)1.73500167
144Encephalitis (HP:0002383)1.71342182
145Aplasia/Hypoplasia of the scapulae (HP:0006713)1.70864812
146Hypoplastic scapulae (HP:0000882)1.70864812
147Dislocated radial head (HP:0003083)1.70677375
148Abnormality of chromosome stability (HP:0003220)1.70653985
149Abnormality of the Achilles tendon (HP:0005109)1.70452716
150Prostate neoplasm (HP:0100787)1.70065078
151Esophageal varix (HP:0002040)1.70011838
152Nephroblastoma (Wilms tumor) (HP:0002667)1.69924123
153Advanced eruption of teeth (HP:0006288)1.69593452
154Upper limb muscle weakness (HP:0003484)1.69457055
155Chronic obstructive pulmonary disease (HP:0006510)1.68957809
156Obstructive lung disease (HP:0006536)1.68957809
157Increased nuchal translucency (HP:0010880)1.68898692
158Neonatal hypoglycemia (HP:0001998)1.67686185
159Wide nose (HP:0000445)1.66462249
160Narrow palate (HP:0000189)1.65654658
161Abnormality of oral frenula (HP:0000190)1.65628646
162Abnormality of macrophages (HP:0004311)1.65008068
163Cheilitis (HP:0100825)1.64854678
164Bronchitis (HP:0012387)1.64499230
165Conjunctival telangiectasia (HP:0000524)1.64383505
166Hypoplastic labia majora (HP:0000059)1.64234248
167Increased density of long bones (HP:0006392)1.64078978
168Sandal gap (HP:0001852)1.63327416
169Male infertility (HP:0003251)1.63128326
170Submucous cleft hard palate (HP:0000176)1.62817057
171Germ cell neoplasia (HP:0100728)1.62586685
172Anal stenosis (HP:0002025)1.61885195
173Spontaneous hematomas (HP:0007420)1.61861903
174Progressive external ophthalmoplegia (HP:0000590)1.61393216
175Osteomyelitis (HP:0002754)1.60887864
176Clubbing of toes (HP:0100760)1.60886052
177Birth length less than 3rd percentile (HP:0003561)1.60838268
178Thrombocytosis (HP:0001894)1.60746194
179Recurrent skin infections (HP:0001581)1.60628414
180Cutis marmorata (HP:0000965)1.60440934
181Abnormality of the distal phalanx of the thumb (HP:0009617)1.60399404
182Hypopigmentation of the fundus (HP:0007894)1.60284095
183Chromosomal breakage induced by crosslinking agents (HP:0003221)1.59473435
184Polycythemia (HP:0001901)1.59409241
185Thickened calvaria (HP:0002684)1.59105228
186Progressive hearing impairment (HP:0001730)1.57241970
187Urethral obstruction (HP:0000796)1.56579606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.32132229
2MAP4K13.90238072
3MAP3K143.26409766
4TXK3.16502091
5STK103.04620584
6EIF2AK12.88490454
7SMG12.44708334
8TRIB32.40637562
9CAMK1G2.38788188
10MAP3K102.11437585
11JAK32.05454353
12SCYL22.02451504
13GRK62.01196224
14MAP3K91.94075364
15LATS11.84601129
16JAK11.77197515
17TYK21.77057657
18IKBKB1.76544682
19FLT31.73150856
20CHUK1.70866003
21PDK21.70671506
22AKT31.69103814
23MET1.63188629
24MAP3K131.60496673
25PIM11.60345806
26ZAP701.56644502
27NEK21.54777879
28ITK1.52538353
29LMTK21.48805347
30TGFBR21.47489404
31CDC71.40875943
32CDK61.38977892
33SIK11.38953977
34RPS6KA41.38075072
35CSF1R1.38043656
36TBK11.36440871
37SIK31.36187980
38IKBKE1.33370007
39TEC1.30669196
40RIPK41.30250829
41SGK21.27977364
42FGFR31.26182682
43MST41.25759556
44FER1.24595959
45CSK1.24026917
46PNCK1.22882479
47BMX1.21944657
48EEF2K1.21387080
49PDGFRA1.19761482
50TIE11.18570451
51BRD41.18110504
52PTK21.14905093
53LCK1.14704109
54HCK1.14364658
55SYK1.13817460
56LATS21.12427594
57IRAK41.10643759
58PDPK11.10605141
59MARK31.09327734
60MST1R1.09158059
61KIT1.08748141
62CDK41.07713992
63PTK61.02422291
64BTK1.01643823
65TYRO30.99299275
66ILK0.98779079
67TAF10.96130686
68MAP3K20.93682015
69STK30.92970708
70PDGFRB0.91100031
71STK40.91031669
72PDK10.89630520
73CAMK1D0.89602387
74CLK10.87528796
75ALK0.86051399
76RPS6KB20.85695763
77RIPK10.84663093
78MELK0.80873266
79BRSK20.80100565
80YES10.77995664
81SIK20.77331205
82LRRK20.77262700
83MATK0.75427948
84PRKAA20.75180158
85MAP2K10.73967052
86NEK60.73515973
87FGFR10.71713191
88MAP3K80.70887935
89ATR0.69174840
90JAK20.68795753
91KDR0.67782112
92CHEK10.67578010
93HIPK20.67240710
94TRPM70.66135511
95CDK70.65084294
96RET0.64598411
97MAPKAPK30.64438567
98PRKCQ0.64269941
99CDK90.63032277
100MAP3K70.62928228
101LYN0.62883171
102EPHA20.62051201
103NLK0.61996864
104IRAK30.60444904
105TAOK10.59681289
106IRAK10.58735361
107SGK4940.58483722
108SGK2230.58483722
109CDK80.56156849
110PIK3CG0.55782142
111ACVR1B0.55531694
112MYLK0.55352202
113KSR20.54942919
114PAK40.54875772
115CAMKK10.54609863
116MAP2K30.54272703
117WEE10.53892031
118FGFR40.52825759
119WNK10.52526286
120DAPK10.51382781
121SGK30.51324131
122ABL10.50885415
123ATM0.50671617
124PAK20.49887350
125TAOK20.49884990
126AURKB0.49642472
127ERN10.47983300
128ERBB40.47721731
129PKN20.47673419
130TTK0.47289632
131STK240.46846440
132PRKD20.46734226
133ICK0.46650952
134CHEK20.45693907
135MAPK70.44426115
136MTOR0.44284593
137EPHB10.44171027
138PLK10.43774336
139MKNK10.43139141
140FES0.43110210
141PRKD30.42733620
142PRPF4B0.42695986
143EIF2AK30.42409881
144EGFR0.42055539
145TSSK60.41946156
146STK110.41922746
147DMPK0.41558766
148BRSK10.40381079
149RPS6KB10.40098462
150EPHA30.39678552

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.64543371
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.33649621
3T cell receptor signaling pathway_Homo sapiens_hsa046601.99811015
4B cell receptor signaling pathway_Homo sapiens_hsa046621.94126064
5Measles_Homo sapiens_hsa051621.87720189
6Renal cell carcinoma_Homo sapiens_hsa052111.84784862
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.80895823
8Osteoclast differentiation_Homo sapiens_hsa043801.77904903
9Leishmaniasis_Homo sapiens_hsa051401.77867106
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76591340
11Fatty acid biosynthesis_Homo sapiens_hsa000611.74143638
12Antigen processing and presentation_Homo sapiens_hsa046121.73008008
13Herpes simplex infection_Homo sapiens_hsa051681.57690846
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50796860
15Allograft rejection_Homo sapiens_hsa053301.47194124
16TNF signaling pathway_Homo sapiens_hsa046681.45279269
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42739657
18Acute myeloid leukemia_Homo sapiens_hsa052211.40973960
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38473591
20Graft-versus-host disease_Homo sapiens_hsa053321.36991606
21Lysine degradation_Homo sapiens_hsa003101.35003968
22Hematopoietic cell lineage_Homo sapiens_hsa046401.34996615
23Toxoplasmosis_Homo sapiens_hsa051451.34154613
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.30401272
25Chronic myeloid leukemia_Homo sapiens_hsa052201.27957959
26Selenocompound metabolism_Homo sapiens_hsa004501.27091746
27Apoptosis_Homo sapiens_hsa042101.26901711
28Influenza A_Homo sapiens_hsa051641.26012907
29Small cell lung cancer_Homo sapiens_hsa052221.25635538
30Insulin signaling pathway_Homo sapiens_hsa049101.25613843
31Hepatitis B_Homo sapiens_hsa051611.23920019
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21575901
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21055358
34AMPK signaling pathway_Homo sapiens_hsa041521.20658448
35Focal adhesion_Homo sapiens_hsa045101.20598980
36Shigellosis_Homo sapiens_hsa051311.20270823
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.20162348
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19868364
39HTLV-I infection_Homo sapiens_hsa051661.18983850
40ECM-receptor interaction_Homo sapiens_hsa045121.18183405
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16337256
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.10804312
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10258294
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09919772
45Legionellosis_Homo sapiens_hsa051341.08171909
46Adherens junction_Homo sapiens_hsa045201.07820219
47MicroRNAs in cancer_Homo sapiens_hsa052061.04674357
48Chemokine signaling pathway_Homo sapiens_hsa040621.04639346
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04296236
50Viral myocarditis_Homo sapiens_hsa054161.03846514
51mTOR signaling pathway_Homo sapiens_hsa041501.03207045
52p53 signaling pathway_Homo sapiens_hsa041151.02926595
53Insulin resistance_Homo sapiens_hsa049311.00637339
54Cell cycle_Homo sapiens_hsa041101.00369790
55Tuberculosis_Homo sapiens_hsa051520.97904132
56Viral carcinogenesis_Homo sapiens_hsa052030.95832883
57VEGF signaling pathway_Homo sapiens_hsa043700.95210823
58Pancreatic cancer_Homo sapiens_hsa052120.94458922
59Tight junction_Homo sapiens_hsa045300.93954079
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93225850
61DNA replication_Homo sapiens_hsa030300.92188297
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91949593
63Colorectal cancer_Homo sapiens_hsa052100.90189153
64Base excision repair_Homo sapiens_hsa034100.88228133
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88081977
66Homologous recombination_Homo sapiens_hsa034400.87857789
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87583574
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.86944399
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.86417998
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.86184021
71Bladder cancer_Homo sapiens_hsa052190.86098790
72Platelet activation_Homo sapiens_hsa046110.84892952
73Epstein-Barr virus infection_Homo sapiens_hsa051690.84622879
74Mismatch repair_Homo sapiens_hsa034300.84043036
75Phenylalanine metabolism_Homo sapiens_hsa003600.83675928
76Melanoma_Homo sapiens_hsa052180.82546894
77Autoimmune thyroid disease_Homo sapiens_hsa053200.81412758
78Vitamin B6 metabolism_Homo sapiens_hsa007500.81216111
79Sphingolipid metabolism_Homo sapiens_hsa006000.80859484
80Fanconi anemia pathway_Homo sapiens_hsa034600.80689575
81Prolactin signaling pathway_Homo sapiens_hsa049170.79726246
82TGF-beta signaling pathway_Homo sapiens_hsa043500.79602326
83One carbon pool by folate_Homo sapiens_hsa006700.79555666
84Non-small cell lung cancer_Homo sapiens_hsa052230.78961148
85Hippo signaling pathway_Homo sapiens_hsa043900.78634992
86Glucagon signaling pathway_Homo sapiens_hsa049220.76531850
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75050546
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73552742
89Inositol phosphate metabolism_Homo sapiens_hsa005620.73283994
90Non-homologous end-joining_Homo sapiens_hsa034500.73231506
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73057115
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72320070
93Proteoglycans in cancer_Homo sapiens_hsa052050.71430716
94Notch signaling pathway_Homo sapiens_hsa043300.71130562
95Thyroid cancer_Homo sapiens_hsa052160.70741376
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70687953
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70540314
98African trypanosomiasis_Homo sapiens_hsa051430.70084830
99Long-term potentiation_Homo sapiens_hsa047200.69211905
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68973417
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68717945
102Dorso-ventral axis formation_Homo sapiens_hsa043200.68683993
103mRNA surveillance pathway_Homo sapiens_hsa030150.68538085
104N-Glycan biosynthesis_Homo sapiens_hsa005100.68358899
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68227710
106Estrogen signaling pathway_Homo sapiens_hsa049150.67545938
107RNA transport_Homo sapiens_hsa030130.67533757
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67217581
109Glioma_Homo sapiens_hsa052140.66938101
110Hepatitis C_Homo sapiens_hsa051600.66610734
111FoxO signaling pathway_Homo sapiens_hsa040680.66333601
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.66227613
113MAPK signaling pathway_Homo sapiens_hsa040100.65181935
114Prostate cancer_Homo sapiens_hsa052150.64671899
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63510260
116Endometrial cancer_Homo sapiens_hsa052130.61917857
117Complement and coagulation cascades_Homo sapiens_hsa046100.61576272
118Endocytosis_Homo sapiens_hsa041440.61545963
119HIF-1 signaling pathway_Homo sapiens_hsa040660.60734475
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60553632
121Salmonella infection_Homo sapiens_hsa051320.59648565
122Pertussis_Homo sapiens_hsa051330.58863566
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57746465
124Choline metabolism in cancer_Homo sapiens_hsa052310.57601039
125Malaria_Homo sapiens_hsa051440.57371597
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56836094
127beta-Alanine metabolism_Homo sapiens_hsa004100.56259252
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56025845
129Gap junction_Homo sapiens_hsa045400.55921329
130ErbB signaling pathway_Homo sapiens_hsa040120.54302136
131Pathways in cancer_Homo sapiens_hsa052000.53769845
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53511867
133Type I diabetes mellitus_Homo sapiens_hsa049400.52387000
134Spliceosome_Homo sapiens_hsa030400.51220894
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50537702
136Rap1 signaling pathway_Homo sapiens_hsa040150.49362250
137Fatty acid metabolism_Homo sapiens_hsa012120.49072239
138Thyroid hormone synthesis_Homo sapiens_hsa049180.48237216
139Wnt signaling pathway_Homo sapiens_hsa043100.47711276
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47503814
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.44571349
142ABC transporters_Homo sapiens_hsa020100.40788370
143Steroid biosynthesis_Homo sapiens_hsa001000.39952258
144Fatty acid elongation_Homo sapiens_hsa000620.39777063
145Pancreatic secretion_Homo sapiens_hsa049720.39154391
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38886065
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38273384
148cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37749236

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