MTMR14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.09364144
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.09364144
3piRNA metabolic process (GO:0034587)5.02868508
4neutrophil activation involved in immune response (GO:0002283)4.71656707
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.60504278
6regulation of RIG-I signaling pathway (GO:0039535)4.56126765
7regulation of B cell receptor signaling pathway (GO:0050855)4.49232968
8negative regulation of interleukin-12 production (GO:0032695)4.47756892
9response to peptidoglycan (GO:0032494)4.45203802
10mitotic metaphase plate congression (GO:0007080)4.40991235
11mitotic chromosome condensation (GO:0007076)4.38981834
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.28818795
13protein K6-linked ubiquitination (GO:0085020)4.27484843
14regulation of gamma-delta T cell activation (GO:0046643)4.22302338
15histone H2A monoubiquitination (GO:0035518)4.17224978
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.17051017
17detection of other organism (GO:0098543)4.11029245
18DNA damage induced protein phosphorylation (GO:0006975)4.07913612
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.01781024
20detection of bacterium (GO:0016045)3.97095760
21cellular extravasation (GO:0045123)3.96061668
22macrophage activation involved in immune response (GO:0002281)3.92605033
23regulation of exit from mitosis (GO:0007096)3.90219423
24regulation of mast cell degranulation (GO:0043304)3.87976839
25regulation of gamma-delta T cell differentiation (GO:0045586)3.79259315
26negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.79033892
27positive regulation of B cell differentiation (GO:0045579)3.78701849
28respiratory burst (GO:0045730)3.72314378
29leukocyte aggregation (GO:0070486)3.72139256
30histone H2A ubiquitination (GO:0033522)3.71086399
31negative regulation of meiosis (GO:0045835)3.68856449
32regulation of female gonad development (GO:2000194)3.67701094
33regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.62480347
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61809035
35DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.59764794
36DNA damage response, signal transduction resulting in transcription (GO:0042772)3.55465468
37metaphase plate congression (GO:0051310)3.55456987
38establishment of chromosome localization (GO:0051303)3.54668389
39fat-soluble vitamin biosynthetic process (GO:0042362)3.54306243
40regulation of mast cell activation involved in immune response (GO:0033006)3.52522898
41granulocyte activation (GO:0036230)3.50818108
42immunoglobulin mediated immune response (GO:0016064)3.48262314
43neutrophil activation (GO:0042119)3.45326668
44regulation of histone H3-K27 methylation (GO:0061085)3.42931937
45B cell receptor signaling pathway (GO:0050853)3.42724023
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.40598783
47NIK/NF-kappaB signaling (GO:0038061)3.40060083
48regulation of interferon-beta biosynthetic process (GO:0045357)3.39948569
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.39100150
50regulation of meiosis (GO:0040020)3.39027897
51cellular response to virus (GO:0098586)3.37795612
52positive thymic T cell selection (GO:0045059)3.35657122
53myeloid cell activation involved in immune response (GO:0002275)3.35428814
54germinal center formation (GO:0002467)3.33902572
55detection of external biotic stimulus (GO:0098581)3.33597670
56mitotic nuclear envelope disassembly (GO:0007077)3.32008285
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.31937692
58mitotic sister chromatid segregation (GO:0000070)3.31553829
59defense response to protozoan (GO:0042832)3.30077011
60regulation of leukocyte degranulation (GO:0043300)3.28197394
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.26885329
62regulation of sister chromatid cohesion (GO:0007063)3.25301898
63protein localization to chromosome, centromeric region (GO:0071459)3.24809257
64negative regulation of erythrocyte differentiation (GO:0045647)3.24079780
65regulation of B cell differentiation (GO:0045577)3.23473847
66positive regulation of mast cell activation (GO:0033005)3.22648224
67regulation of mast cell activation (GO:0033003)3.22469595
68base-excision repair, AP site formation (GO:0006285)3.21444172
69protein localization to kinetochore (GO:0034501)3.17699085
70T cell migration (GO:0072678)3.17586794
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.16548445
72response to host immune response (GO:0052572)3.16548445
73regulation of meiosis I (GO:0060631)3.16176902
74female gamete generation (GO:0007292)3.16085358
75oocyte maturation (GO:0001556)3.14879710
76lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14635022
77negative regulation of leukocyte mediated immunity (GO:0002704)3.14036299
78regulation of spindle organization (GO:0090224)3.13793974
79interferon-gamma-mediated signaling pathway (GO:0060333)3.11928430
80gene silencing by RNA (GO:0031047)3.10023644
81nuclear envelope disassembly (GO:0051081)3.09116433
82membrane disassembly (GO:0030397)3.09116433
83response to protozoan (GO:0001562)3.08672349
84negative regulation of lymphocyte mediated immunity (GO:0002707)3.08637317
85meiotic chromosome segregation (GO:0045132)3.08081240
86Arp2/3 complex-mediated actin nucleation (GO:0034314)3.07243282
87meiotic cell cycle (GO:0051321)3.06834984
88natural killer cell mediated cytotoxicity (GO:0042267)3.06825746
89natural killer cell mediated immunity (GO:0002228)3.06825746
90type I interferon signaling pathway (GO:0060337)3.03704626
91cellular response to type I interferon (GO:0071357)3.03704626
92monoubiquitinated protein deubiquitination (GO:0035520)3.02794857
93response to type I interferon (GO:0034340)2.99992197
94negative regulation of T cell mediated immunity (GO:0002710)2.99874234
95detection of biotic stimulus (GO:0009595)2.99253087
96maturation of 5.8S rRNA (GO:0000460)2.99183547
97regulation of dendritic cell antigen processing and presentation (GO:0002604)2.97473249
98response to muramyl dipeptide (GO:0032495)2.95439277
99detection of molecule of bacterial origin (GO:0032490)2.94355127
100attachment of spindle microtubules to kinetochore (GO:0008608)2.93921392
101folic acid-containing compound biosynthetic process (GO:0009396)2.93762100
102negative thymic T cell selection (GO:0045060)2.91034484
103DNA replication-dependent nucleosome assembly (GO:0006335)2.90883788
104DNA replication-dependent nucleosome organization (GO:0034723)2.90883788
105positive regulation of antigen processing and presentation (GO:0002579)2.90533097
106regulation of antigen processing and presentation (GO:0002577)2.90140237
107myeloid dendritic cell activation (GO:0001773)2.90124864
108negative regulation of phagocytosis (GO:0050765)2.88920443
109leukocyte degranulation (GO:0043299)2.88839074
110DNA replication checkpoint (GO:0000076)2.88681938
111negative regulation of histone methylation (GO:0031061)2.88467507
112neutrophil mediated immunity (GO:0002446)2.88057864
113positive regulation of mast cell degranulation (GO:0043306)2.86834964
114positive regulation of mast cell activation involved in immune response (GO:0033008)2.86834964
115B cell mediated immunity (GO:0019724)2.86553960
116chromosome segregation (GO:0007059)2.84860806
117response to interleukin-15 (GO:0070672)2.83589988
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.83067197
119response to host (GO:0075136)2.83067197
120response to host defenses (GO:0052200)2.83067197
121sister chromatid segregation (GO:0000819)2.82999212
122regulation of T cell tolerance induction (GO:0002664)2.82804741
123positive regulation by symbiont of host defense response (GO:0052509)2.82558187
124modulation by symbiont of host defense response (GO:0052031)2.82558187
125modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82558187
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82558187
127positive regulation by organism of defense response of other organism involved in symbiotic interact2.82558187
128modulation by symbiont of host immune response (GO:0052553)2.82558187
129myeloid dendritic cell differentiation (GO:0043011)2.82124050
130regulation of retinoic acid receptor signaling pathway (GO:0048385)2.81934983
131macrophage activation (GO:0042116)2.80177115
132protein localization to chromosome (GO:0034502)2.79844053
133regulation of mitotic spindle organization (GO:0060236)2.77114050
134mismatch repair (GO:0006298)2.76825469
135negative T cell selection (GO:0043383)2.76443779
136regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75608543
137negative regulation of innate immune response (GO:0045824)2.73991424
138production of molecular mediator involved in inflammatory response (GO:0002532)2.73827760
139negative regulation of cytokine production involved in immune response (GO:0002719)2.73467087
1403-UTR-mediated mRNA stabilization (GO:0070935)2.72906445
141kinetochore assembly (GO:0051382)2.72378077
142regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.72202685
143tolerance induction (GO:0002507)2.71544258
144mitotic sister chromatid cohesion (GO:0007064)2.71044126
145pyrimidine nucleotide catabolic process (GO:0006244)2.70159362
146positive regulation of humoral immune response (GO:0002922)2.69644909
147T cell selection (GO:0045058)2.69630208
148regulation of early endosome to late endosome transport (GO:2000641)2.69569132
149regulation of chromosome segregation (GO:0051983)2.69343898
150regulation of natural killer cell mediated immunity (GO:0002715)2.68093524
151regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.68093524
152CENP-A containing nucleosome assembly (GO:0034080)2.67858972
153DNA replication-independent nucleosome assembly (GO:0006336)2.67734426
154DNA replication-independent nucleosome organization (GO:0034724)2.67734426
155positive regulation of megakaryocyte differentiation (GO:0045654)2.67330881
156regulation of regulated secretory pathway (GO:1903305)2.66492591
157microglial cell activation (GO:0001774)2.66316933
158chromatin remodeling at centromere (GO:0031055)2.66164848
159male meiosis (GO:0007140)2.65636032
160regulation of tolerance induction (GO:0002643)2.65188247
161positive T cell selection (GO:0043368)2.64973919
162regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64497948
163myeloid leukocyte activation (GO:0002274)2.62617933
164DNA methylation involved in gamete generation (GO:0043046)2.62498067
165negative regulation of interleukin-6 production (GO:0032715)2.61030859
166positive regulation of T cell apoptotic process (GO:0070234)2.60030257
167positive regulation of interferon-alpha production (GO:0032727)2.58590817
168regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58528435
169regulation of mononuclear cell migration (GO:0071675)2.57458767
170DNA replication initiation (GO:0006270)2.56919644
171spindle checkpoint (GO:0031577)2.56615896
172positive regulation of gamma-delta T cell activation (GO:0046645)2.56078560
173positive regulation of chromosome segregation (GO:0051984)2.53862785
174negative regulation of smooth muscle cell differentiation (GO:0051151)2.53855707
175kinetochore organization (GO:0051383)2.52893182
176nuclear envelope organization (GO:0006998)2.50137615
177DNA methylation (GO:0006306)2.48686781
178DNA alkylation (GO:0006305)2.48686781
179negative regulation of DNA-templated transcription, elongation (GO:0032785)2.48595364
180negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.48595364
181regulation of telomere maintenance via telomerase (GO:0032210)2.47423343
182citrulline biosynthetic process (GO:0019240)2.45356418
183modulation by symbiont of host cellular process (GO:0044068)2.43749409
184regulation of interferon-alpha production (GO:0032647)2.43332577
185chromatin assembly or disassembly (GO:0006333)2.41832058
186antigen processing and presentation of endogenous antigen (GO:0019883)2.40899501
187regulation of meiotic cell cycle (GO:0051445)2.40039390
188nuclear pore complex assembly (GO:0051292)2.39945368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.11867803
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.02329282
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.36749642
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.15857618
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88888546
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77777338
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.74014759
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.64919735
9* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34644300
10MYC_22102868_ChIP-Seq_BL_Human2.26901026
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25930556
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19475631
13SCL_19346495_ChIP-Seq_HPC-7_Human2.10296048
14SPI1_23127762_ChIP-Seq_K562_Human2.06301835
15AR_21909140_ChIP-Seq_LNCAP_Human2.06233106
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90604792
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.89936826
18RUNX_20019798_ChIP-Seq_JUKART_Human1.88323421
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87910352
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.87142068
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.86017530
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85114771
23* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82240859
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.80882643
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76562585
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73865307
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73440193
28VDR_21846776_ChIP-Seq_THP-1_Human1.66619374
29* IRF8_27001747_Chip-Seq_BMDM_Mouse1.66436481
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64279826
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63630729
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63088029
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61378065
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60750238
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59966123
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58780473
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58285716
38KAP1_22055183_ChIP-Seq_ESCs_Mouse1.55437704
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54576331
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53892482
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50425808
42* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49860767
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49614277
44* SPI1_23547873_ChIP-Seq_NB4_Human1.48195435
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48098301
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47506728
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.47120532
48* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46533304
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45383315
50KDM2B_26808549_Chip-Seq_DND41_Human1.44177846
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42976982
52BCL6_27268052_Chip-Seq_Bcells_Human1.41210826
53GATA3_27048872_Chip-Seq_THYMUS_Human1.38619066
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37748210
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37451531
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.37412336
57* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37124129
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36583969
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35098187
60PU.1_20513432_ChIP-Seq_Bcells_Mouse1.34561872
61BCOR_27268052_Chip-Seq_Bcells_Human1.34465050
62KDM5A_27292631_Chip-Seq_BREAST_Human1.34174543
63LXR_22292898_ChIP-Seq_THP-1_Human1.34111355
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33493835
65VDR_23849224_ChIP-Seq_CD4+_Human1.32918296
66CIITA_25753668_ChIP-Seq_RAJI_Human1.29464327
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27585666
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27296383
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.26046489
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25628703
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24998650
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23893209
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23323674
74DCP1A_22483619_ChIP-Seq_HELA_Human1.22127903
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21678619
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.21297272
77* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20519361
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20309704
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.20212139
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20176182
81MYB_26560356_Chip-Seq_TH2_Human1.20055133
82* GABP_19822575_ChIP-Seq_HepG2_Human1.20011619
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19385317
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19315510
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.18946468
86UTX_26944678_Chip-Seq_JUKART_Human1.18789278
87MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18761184
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.18543885
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18388974
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17616594
91TFEB_21752829_ChIP-Seq_HELA_Human1.17541651
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17006186
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16986646
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16884239
95MAF_26560356_Chip-Seq_TH1_Human1.16881249
96VDR_24787735_ChIP-Seq_THP-1_Human1.16724824
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16241150
98FOXP3_21729870_ChIP-Seq_TREG_Human1.15655110
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15196195
100XRN2_22483619_ChIP-Seq_HELA_Human1.15125656
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14182394
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13984657
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13919119
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13624658
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12442754
106TCF7_22412390_ChIP-Seq_EML_Mouse1.12333702
107MYB_26560356_Chip-Seq_TH1_Human1.12105304
108NCOR1_26117541_ChIP-Seq_K562_Human1.11812475
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11107034
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10790024
111ETS1_20019798_ChIP-Seq_JURKAT_Human1.10255123
112GATA3_26560356_Chip-Seq_TH2_Human1.09352117
113SALL1_21062744_ChIP-ChIP_HESCs_Human1.08959864
114KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08871100
115VDR_24763502_ChIP-Seq_THP-1_Human1.07557279
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05608025
117ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05110076
118GATA1_19941826_ChIP-Seq_K562_Human1.04570422
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04225947
120P68_20966046_ChIP-Seq_HELA_Human1.03923607
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03510083
122PU_27001747_Chip-Seq_BMDM_Mouse1.02942908
123ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01015433
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00455641
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99034611
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98991009
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98072874
128CTCF_26484167_Chip-Seq_Bcells_Mouse0.97966512
129MYC_18940864_ChIP-ChIP_HL60_Human0.97966361
130MAF_26560356_Chip-Seq_TH2_Human0.97792022
131TP63_19390658_ChIP-ChIP_HaCaT_Human0.97723415
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96926641
133SPI1_20517297_ChIP-Seq_HL60_Human0.95808678
134STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95774950
135SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95236272
136VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94410470
137* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93701353
138ATF3_27146783_Chip-Seq_COLON_Human0.92314099
139CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92219892
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91666097
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.91520190
142STAT1_20625510_ChIP-Seq_HELA_Human0.91271704
143CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90805998
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90678048
145NOTCH1_21737748_ChIP-Seq_TLL_Human0.90569893
146P300_27268052_Chip-Seq_Bcells_Human0.89411345
147Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88985328
148* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88895739
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.86321339
150GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85528526
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84350824
152SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82082683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.74010359
2MP0003718_maternal_effect3.33645438
3MP0003303_peritoneal_inflammation3.21895977
4MP0003724_increased_susceptibility_to3.20669857
5MP0003077_abnormal_cell_cycle2.94360321
6MP0003111_abnormal_nucleus_morphology2.93413669
7MP0010094_abnormal_chromosome_stability2.83302114
8MP0005451_abnormal_body_composition2.80972134
9MP0001835_abnormal_antigen_presentation2.57207770
10MP0005058_abnormal_lysosome_morphology2.49785223
11MP0009278_abnormal_bone_marrow2.44611419
12MP0004957_abnormal_blastocyst_morpholog2.42735613
13MP0003191_abnormal_cellular_cholesterol2.03020063
14MP0003172_abnormal_lysosome_physiology2.02015446
15MP0002653_abnormal_ependyma_morphology1.98249167
16MP0000685_abnormal_immune_system1.97492771
17MP0008877_abnormal_DNA_methylation1.96760078
18MP0002102_abnormal_ear_morphology1.96749538
19MP0001800_abnormal_humoral_immune1.93570281
20MP0004510_myositis1.92242919
21MP0009840_abnormal_foam_cell1.90122986
22MP0003300_gastrointestinal_ulcer1.88598811
23MP0009785_altered_susceptibility_to1.87899333
24MP0001545_abnormal_hematopoietic_system1.85520422
25MP0005397_hematopoietic_system_phenotyp1.85520422
26MP0003436_decreased_susceptibility_to1.82503818
27MP0002452_abnormal_antigen_presenting1.81427012
28MP0009764_decreased_sensitivity_to1.79431304
29MP0003806_abnormal_nucleotide_metabolis1.78297085
30MP0001533_abnormal_skeleton_physiology1.75388782
31MP0005076_abnormal_cell_differentiation1.74379974
32MP0005000_abnormal_immune_tolerance1.69337797
33MP0003828_pulmonary_edema1.66110471
34MP0002723_abnormal_immune_serum1.65207238
35MP0005025_abnormal_response_to1.60485551
36MP0001119_abnormal_female_reproductive1.59205101
37MP0001790_abnormal_immune_system1.58908079
38MP0005387_immune_system_phenotype1.58908079
39MP0002398_abnormal_bone_marrow1.58360479
40MP0010307_abnormal_tumor_latency1.58087656
41MP0001730_embryonic_growth_arrest1.52267133
42MP0002419_abnormal_innate_immunity1.51385552
43MP0000689_abnormal_spleen_morphology1.51383289
44MP0005310_abnormal_salivary_gland1.51281155
45MP0005395_other_phenotype1.50797828
46MP0000350_abnormal_cell_proliferation1.50736623
47MP0003763_abnormal_thymus_physiology1.49778708
48MP0001819_abnormal_immune_cell1.49455864
49MP0000490_abnormal_crypts_of1.49048667
50MP0009333_abnormal_splenocyte_physiolog1.48100731
51MP0005671_abnormal_response_to1.47684614
52MP0002420_abnormal_adaptive_immunity1.46956770
53MP0002019_abnormal_tumor_incidence1.46788263
54MP0008007_abnormal_cellular_replicative1.45303515
55MP0003699_abnormal_female_reproductive1.44459185
56MP0000465_gastrointestinal_hemorrhage1.38012339
57MP0002405_respiratory_system_inflammati1.35949971
58MP0000716_abnormal_immune_system1.35229469
59MP0000858_altered_metastatic_potential1.32966573
60MP0003123_paternal_imprinting1.31994354
61MP0008932_abnormal_embryonic_tissue1.31040538
62MP0002148_abnormal_hypersensitivity_rea1.30284269
63MP0008057_abnormal_DNA_replication1.30115508
64MP0003075_altered_response_to1.29456323
65MP0001873_stomach_inflammation1.27262177
66MP0006082_CNS_inflammation1.27020265
67MP0003866_abnormal_defecation1.26356361
68MP0002722_abnormal_immune_system1.25323820
69MP0001929_abnormal_gametogenesis1.24877196
70MP0010352_gastrointestinal_tract_polyps1.23683418
71MP0002429_abnormal_blood_cell1.23071674
72MP0005464_abnormal_platelet_physiology1.22987526
73MP0002210_abnormal_sex_determination1.22388872
74MP0004808_abnormal_hematopoietic_stem1.19806357
75MP0003453_abnormal_keratinocyte_physiol1.18393758
76MP0001672_abnormal_embryogenesis/_devel1.17284475
77MP0005380_embryogenesis_phenotype1.17284475
78MP0005257_abnormal_intraocular_pressure1.16665806
79MP0002132_abnormal_respiratory_system1.16329928
80MP0001853_heart_inflammation1.16017262
81MP0001697_abnormal_embryo_size1.15973569
82MP0001915_intracranial_hemorrhage1.15904935
83MP0002998_abnormal_bone_remodeling1.15850858
84MP0005075_abnormal_melanosome_morpholog1.14181087
85MP0000604_amyloidosis1.13712280
86MP0000653_abnormal_sex_gland1.13697188
87MP0006292_abnormal_olfactory_placode1.12823512
88MP0001845_abnormal_inflammatory_respons1.12273565
89MP0005408_hypopigmentation1.11788129
90MP0004947_skin_inflammation1.08996449
91MP0000313_abnormal_cell_death1.08698401
92MP0004381_abnormal_hair_follicle1.06538921
93MP0008260_abnormal_autophagy1.05236885
94MP0003183_abnormal_peptide_metabolism1.04644835
95MP0000703_abnormal_thymus_morphology1.04403787
96MP0002085_abnormal_embryonic_tissue1.03562442
97MP0000015_abnormal_ear_pigmentation1.02667720
98MP0002877_abnormal_melanocyte_morpholog1.00949001
99MP0005166_decreased_susceptibility_to0.99706773
100MP0003984_embryonic_growth_retardation0.97497553
101MP0010155_abnormal_intestine_physiology0.97430721
102MP0003448_altered_tumor_morphology0.97155083
103MP0008058_abnormal_DNA_repair0.97085248
104MP0004185_abnormal_adipocyte_glucose0.96747313
105MP0008004_abnormal_stomach_pH0.95635671
106MP0002088_abnormal_embryonic_growth/wei0.94499308
107MP0001145_abnormal_male_reproductive0.93799886
108MP0005621_abnormal_cell_physiology0.92652936
109MP0002254_reproductive_system_inflammat0.89566264
110MP0002080_prenatal_lethality0.88892762
111MP0001663_abnormal_digestive_system0.88755107
112MP0002084_abnormal_developmental_patter0.88222414
113MP0000343_altered_response_to0.86898794
114MP0002086_abnormal_extraembryonic_tissu0.86422917
115MP0002166_altered_tumor_susceptibility0.85276435
116MP0002138_abnormal_hepatobiliary_system0.84215278
117MP0003656_abnormal_erythrocyte_physiolo0.83382225
118MP0002277_abnormal_respiratory_mucosa0.82698814
119MP0008469_abnormal_protein_level0.81500098
120MP0003186_abnormal_redox_activity0.80336213
121MP0000569_abnormal_digit_pigmentation0.79439726
122MP0004883_abnormal_blood_vessel0.78333396
123MP0009763_increased_sensitivity_to0.76893049
124MP0002006_tumorigenesis0.74091082
125MP0002396_abnormal_hematopoietic_system0.72703150
126MP0005360_urolithiasis0.72518511
127MP0005319_abnormal_enzyme/_coenzyme0.71224610
128MP0001986_abnormal_taste_sensitivity0.70605615
129MP0003221_abnormal_cardiomyocyte_apopto0.70417258
130MP0000609_abnormal_liver_physiology0.69688262
131MP0006036_abnormal_mitochondrial_physio0.68415589
132MP0005167_abnormal_blood-brain_barrier0.66428708
133MP0008874_decreased_physiological_sensi0.65983016
134MP0009765_abnormal_xenobiotic_induced0.65959400
135MP0001851_eye_inflammation0.64214763
136MP0005164_abnormal_response_to0.61752620
137MP0000371_diluted_coat_color0.59088854
138MP0000249_abnormal_blood_vessel0.58398946
139MP0002933_joint_inflammation0.57745159
140MP0003690_abnormal_glial_cell0.57646263
141MP0005390_skeleton_phenotype0.56864807
142MP0003795_abnormal_bone_structure0.56495138
143MP0006035_abnormal_mitochondrial_morpho0.53732034
144MP0005584_abnormal_enzyme/coenzyme_acti0.52946450
145MP0002139_abnormal_hepatobiliary_system0.51759117

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)5.06711468
2Abnormality of glycolipid metabolism (HP:0010969)4.54566899
3Abnormality of liposaccharide metabolism (HP:0010968)4.54566899
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.54566899
5Recurrent bacterial skin infections (HP:0005406)4.35502459
6Recurrent abscess formation (HP:0002722)4.15415627
7Obstructive lung disease (HP:0006536)3.95383154
8Chronic obstructive pulmonary disease (HP:0006510)3.95383154
9Gastrointestinal infarctions (HP:0005244)3.93656273
10Increased cerebral lipofuscin (HP:0011813)3.72181082
11Chromsome breakage (HP:0040012)3.58529509
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.54948267
13Premature ovarian failure (HP:0008209)3.54383632
14Nasal polyposis (HP:0100582)3.51786084
15Male infertility (HP:0003251)3.48932972
16Cortical dysplasia (HP:0002539)3.21624951
17Vacuolated lymphocytes (HP:0001922)3.21284977
18Breast hypoplasia (HP:0003187)3.21257581
19Birth length less than 3rd percentile (HP:0003561)3.19218980
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.17379817
21Urticaria (HP:0001025)3.14219977
22Patellar aplasia (HP:0006443)3.11152060
23Encephalitis (HP:0002383)3.04238627
24Spontaneous hematomas (HP:0007420)3.02723598
25Myositis (HP:0100614)2.97217962
26Mediastinal lymphadenopathy (HP:0100721)2.97149225
27T lymphocytopenia (HP:0005403)2.96896648
28Neoplasm of head and neck (HP:0012288)2.94387818
29Esophageal neoplasm (HP:0100751)2.94387818
30Abnormality of the nasal mucosa (HP:0000433)2.94352726
31Elevated erythrocyte sedimentation rate (HP:0003565)2.94136138
32Autoimmune thrombocytopenia (HP:0001973)2.94107766
33Recurrent gram-negative bacterial infections (HP:0005420)2.91211101
34Gingivitis (HP:0000230)2.88907300
35Eczematoid dermatitis (HP:0000976)2.87562404
36Retrobulbar optic neuritis (HP:0100654)2.84561999
37Optic neuritis (HP:0100653)2.84561999
38Increased IgE level (HP:0003212)2.83253276
39Aplasia/Hypoplasia of the patella (HP:0006498)2.82642696
40Petechiae (HP:0000967)2.81534074
41Abnormality of T cell number (HP:0011839)2.81361734
42Loss of speech (HP:0002371)2.79664411
43Increased IgM level (HP:0003496)2.74943449
44Inflammation of the large intestine (HP:0002037)2.72198868
45Secondary amenorrhea (HP:0000869)2.71834554
46Gastrointestinal inflammation (HP:0004386)2.69949412
47Orchitis (HP:0100796)2.68360326
48Increased serum ferritin (HP:0003281)2.67927320
49Chest pain (HP:0100749)2.66236821
50Recurrent skin infections (HP:0001581)2.66172174
51Prolonged bleeding time (HP:0003010)2.65875879
52Dysostosis multiplex (HP:0000943)2.64427319
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.63907720
54Thrombocytosis (HP:0001894)2.61455602
55Hypochromic anemia (HP:0001931)2.60840322
56Pulmonary fibrosis (HP:0002206)2.60086702
57Aplastic anemia (HP:0001915)2.57860106
58Purpura (HP:0000979)2.57124320
59Abnormality of T cells (HP:0002843)2.54839442
60Recurrent viral infections (HP:0004429)2.52285567
61Panhypogammaglobulinemia (HP:0003139)2.51134892
62Abnormality of chromosome stability (HP:0003220)2.48082004
63Hemoptysis (HP:0002105)2.43102354
64Epistaxis (HP:0000421)2.42694718
65Hepatosplenomegaly (HP:0001433)2.42675968
66Prostate neoplasm (HP:0100787)2.42134726
67Cellulitis (HP:0100658)2.41196835
68Oral leukoplakia (HP:0002745)2.39506969
69Granulocytopenia (HP:0001913)2.38667153
70Keratoconjunctivitis (HP:0001096)2.38145688
71Vasculitis (HP:0002633)2.37661562
72Gastrointestinal stroma tumor (HP:0100723)2.36289932
73Acute myeloid leukemia (HP:0004808)2.36024987
74Systemic lupus erythematosus (HP:0002725)2.35654000
75Myelodysplasia (HP:0002863)2.35455617
76Osteomyelitis (HP:0002754)2.33898063
77Recurrent fungal infections (HP:0002841)2.32913461
78Amyloidosis (HP:0011034)2.30095996
79Agnosia (HP:0010524)2.27285402
80Disinhibition (HP:0000734)2.26176792
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.25626618
82Facial hemangioma (HP:0000329)2.23845578
83Abnormality of iron homeostasis (HP:0011031)2.23258777
84Pustule (HP:0200039)2.22542386
85Clubbing of toes (HP:0100760)2.21414548
86Pulmonary infiltrates (HP:0002113)2.20354599
87Abnormality of macrophages (HP:0004311)2.19395301
88Biliary tract neoplasm (HP:0100574)2.19280981
89Anorexia (HP:0002039)2.18953824
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17355979
91Fatigue (HP:0012378)2.14631530
92Cleft eyelid (HP:0000625)2.13668938
93Polyneuropathy (HP:0001271)2.13289501
94Ectopic kidney (HP:0000086)2.12990945
95Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12413941
96Overlapping toe (HP:0001845)2.11750889
97Ragged-red muscle fibers (HP:0003200)2.10521662
98Recurrent pneumonia (HP:0006532)2.10261363
99Hypergammaglobulinemia (HP:0010702)2.09878285
100Carpal bone hypoplasia (HP:0001498)2.09776941
101Abnormality of T cell physiology (HP:0011840)2.08802420
102Rectal prolapse (HP:0002035)2.07674516
103Emphysema (HP:0002097)2.07308523
104Autoimmune hemolytic anemia (HP:0001890)2.07218799
105Meckel diverticulum (HP:0002245)2.06707737
106Sepsis (HP:0100806)2.06438502
107Episodic fever (HP:0001954)2.05671635
108Acute hepatic failure (HP:0006554)2.04685665
109Arterial thrombosis (HP:0004420)2.03029604
110Gingival bleeding (HP:0000225)2.02736379
111Hypertensive crisis (HP:0100735)2.01445135
112Pulmonary embolism (HP:0002204)2.00194135
113Breast aplasia (HP:0100783)1.99218003
114Flat capital femoral epiphysis (HP:0003370)1.98091443
115Eosinophilia (HP:0001880)1.97597537
116Hypergonadotropic hypogonadism (HP:0000815)1.97220013
117Agammaglobulinemia (HP:0004432)1.97046865
118Abnormality of the preputium (HP:0100587)1.96724674
119Aplasia/Hypoplasia of the breasts (HP:0010311)1.96395537
120Abnormal delayed hypersensitivity skin test (HP:0002963)1.95914103
121Albinism (HP:0001022)1.95868657
122Abnormality of the ileum (HP:0001549)1.95196672
123Upper motor neuron abnormality (HP:0002127)1.95195470
124Leukopenia (HP:0001882)1.95068493
125Gangrene (HP:0100758)1.92173135
126Abnormality of lateral ventricle (HP:0030047)1.91890505
127Chronic diarrhea (HP:0002028)1.91883048
128Hematochezia (HP:0002573)1.91665902
129Restrictive lung disease (HP:0002091)1.91081038
130Leukocytosis (HP:0001974)1.90810296
131Abnormality of polysaccharide metabolism (HP:0011012)1.90694172
132Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90694172
133Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90694172
134Myocardial infarction (HP:0001658)1.90062524
135Bone marrow hypocellularity (HP:0005528)1.89972678
136Shawl scrotum (HP:0000049)1.88566987
137IgM deficiency (HP:0002850)1.87969368
138Sandal gap (HP:0001852)1.84834482
139Cafe-au-lait spot (HP:0000957)1.84527699
140Abnormality of the prostate (HP:0008775)1.82612853
141Meningitis (HP:0001287)1.82054458
142Chronic otitis media (HP:0000389)1.80898479
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.80546020
144Chronic mucocutaneous candidiasis (HP:0002728)1.79327624
145Recurrent cutaneous fungal infections (HP:0011370)1.79327624
146Colitis (HP:0002583)1.78804977
147Infertility (HP:0000789)1.77478387
148Gastrointestinal carcinoma (HP:0002672)1.76903725
149Malignant gastrointestinal tract tumors (HP:0006749)1.76903725
150Lymphopenia (HP:0001888)1.76622174
151Hypoplasia of the fovea (HP:0007750)1.75051343
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.75051343
153Combined immunodeficiency (HP:0005387)1.74796379
154Cellular immunodeficiency (HP:0005374)1.74592804
155Neoplasm of the small intestine (HP:0100833)1.74244784
156Stomatitis (HP:0010280)1.74142088
157Recurrent bronchitis (HP:0002837)1.72995300
158Spondylolisthesis (HP:0003302)1.72745757
159Abnormality of the fovea (HP:0000493)1.70782007
160Amaurosis fugax (HP:0100576)1.70349793
161Keratoconjunctivitis sicca (HP:0001097)1.68124562
162Aplasia/Hypoplasia involving the musculature (HP:0001460)1.67982751
163Aseptic necrosis (HP:0010885)1.67917244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K63.18706686
2MAP3K133.05493671
3EEF2K3.04309370
4LATS12.94145217
5KSR22.89350658
6ERBB42.82412400
7MAP2K32.48091829
8PLK42.44756933
9BRAF2.33448461
10NEK22.31636655
11TAOK32.31311264
12TTK2.28088757
13TXK2.27071770
14PRPF4B2.16315989
15LATS22.13447016
16CSK2.12900366
17CDC72.09811332
18TYK22.07356585
19MAP4K12.02284379
20IRAK32.00842752
21FES1.96805552
22ARAF1.94386199
23STK31.92127862
24STK101.86847297
25MAP3K91.70219303
26MAP3K81.67332198
27JAK31.66117432
28STK38L1.65377883
29MOS1.62587343
30BUB11.61277775
31RAF11.55096775
32TNK21.51338213
33GRK61.51299347
34RPS6KA41.50287537
35TBK11.44993822
36EIF2AK11.44727215
37MAPKAPK31.43868636
38MAP3K31.43356624
39MUSK1.42401462
40ACVR1B1.42041264
41MAP3K141.39688175
42KIT1.38038676
43TAOK11.35811703
44PBK1.30681888
45CDK121.29781257
46MARK31.28294963
47SIK31.28126668
48IRAK41.27570761
49SMG11.25322515
50PLK11.21779265
51CDC42BPA1.20507917
52MAP3K11.20092747
53KDR1.19053757
54MELK1.17188770
55TAOK21.14051440
56IKBKB1.12178431
57CHEK21.10771995
58LCK1.10456909
59ITK1.09478181
60IKBKE1.08533948
61CHUK1.08461787
62ABL21.08407071
63TEC1.07051249
64MAP3K51.01280056
65PIM11.00716714
66STK41.00057037
67CDK90.99855589
68AURKB0.94931707
69GRK70.91379104
70CDK80.91335401
71RPS6KB20.91292455
72DYRK20.89134803
73CDK40.87129874
74PIM20.85676548
75WEE10.84460804
76JAK10.84288332
77IRAK20.84262842
78CDK70.83030614
79EPHB10.80640815
80ATR0.78553224
81MAPK110.78318978
82MAP3K100.77397002
83DYRK30.76355642
84MAPK120.74524393
85NME20.73777889
86TGFBR20.73024104
87IRAK10.72843254
88PRKD30.71524642
89BMPR20.71026779
90TLK10.70343457
91RIPK40.67916911
92KSR10.66594824
93SIK20.65140347
94PDK10.64641337
95AURKA0.64354608
96RPS6KA50.63809792
97MAP3K110.61772539
98PDPK10.59416001
99ZAP700.59052700
100PIK3CG0.58912073
101RPS6KA20.58466857
102ERN10.53801651
103PAK40.53753838
104JAK20.52974879
105CSF1R0.52625010
106ATM0.52554826
107MARK20.51899707
108PKN20.51444343
109MAP2K20.51345794
110NEK90.51303073
111SCYL20.51263131
112CLK10.51156360
113PRKCQ0.51127769
114CDK190.49716474
115BTK0.49686631
116PTK60.49499860
117CHEK10.48786321
118RPS6KL10.47547000
119RPS6KC10.47547000
120TRIB30.47175013
121PLK30.46779371
122NLK0.46471922
123HIPK20.45638294
124MAPKAPK20.44566659
125SIK10.44557508
126BMX0.44231899
127PRKD20.44059292
128TESK10.43194143
129RPS6KA10.42405157
130FLT30.39325247
131VRK20.39299160
132FGR0.38521998
133RPS6KA60.38331772
134BCKDK0.38209955
135LRRK20.38132146
136LYN0.37729157
137ABL10.37476024
138SYK0.37091221
139PAK10.36158066
140BLK0.35970633
141MATK0.35287220
142HCK0.34498571
143CAMKK20.33135513
144CDK60.33003316
145CAMK1D0.32523009
146TRPM70.32138437
147CDK20.31072582
148TESK20.30741957
149FYN0.30293606
150MAP2K60.28900074
151MAPK70.28071319
152DYRK1B0.27791949
153YES10.27580370

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.01141101
2DNA replication_Homo sapiens_hsa030302.92700953
3Autoimmune thyroid disease_Homo sapiens_hsa053202.70266210
4Base excision repair_Homo sapiens_hsa034102.38035843
5Mismatch repair_Homo sapiens_hsa034302.09856354
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.07887424
7Type I diabetes mellitus_Homo sapiens_hsa049402.04042665
8RNA degradation_Homo sapiens_hsa030181.92075327
9Leishmaniasis_Homo sapiens_hsa051401.89117017
10Homologous recombination_Homo sapiens_hsa034401.81152230
11Lysosome_Homo sapiens_hsa041421.79420767
12p53 signaling pathway_Homo sapiens_hsa041151.78625427
13RNA transport_Homo sapiens_hsa030131.76263226
14Rheumatoid arthritis_Homo sapiens_hsa053231.72833178
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71969524
16Herpes simplex infection_Homo sapiens_hsa051681.71765495
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68228060
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68205487
19Pancreatic cancer_Homo sapiens_hsa052121.61694202
20Basal transcription factors_Homo sapiens_hsa030221.61327167
21Vitamin B6 metabolism_Homo sapiens_hsa007501.59962495
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59590178
23RNA polymerase_Homo sapiens_hsa030201.59051777
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52910279
25Influenza A_Homo sapiens_hsa051641.52133966
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51787961
27B cell receptor signaling pathway_Homo sapiens_hsa046621.50950315
28Nucleotide excision repair_Homo sapiens_hsa034201.48551008
29Fanconi anemia pathway_Homo sapiens_hsa034601.45665999
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42676246
31One carbon pool by folate_Homo sapiens_hsa006701.38214663
32Phagosome_Homo sapiens_hsa041451.36434698
33Apoptosis_Homo sapiens_hsa042101.36062997
34Measles_Homo sapiens_hsa051621.35488528
35Shigellosis_Homo sapiens_hsa051311.32814899
36Chronic myeloid leukemia_Homo sapiens_hsa052201.32004823
37Hepatitis B_Homo sapiens_hsa051611.29932536
38TNF signaling pathway_Homo sapiens_hsa046681.29186962
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21424425
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21279315
41Primary immunodeficiency_Homo sapiens_hsa053401.17974912
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.16223510
43Osteoclast differentiation_Homo sapiens_hsa043801.15216814
44Malaria_Homo sapiens_hsa051441.15119605
45Epstein-Barr virus infection_Homo sapiens_hsa051691.14392902
46Pyrimidine metabolism_Homo sapiens_hsa002401.14115911
47MicroRNAs in cancer_Homo sapiens_hsa052061.13288490
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.12051918
49mTOR signaling pathway_Homo sapiens_hsa041501.11825998
50Legionellosis_Homo sapiens_hsa051341.11771320
51Salmonella infection_Homo sapiens_hsa051321.08170131
52Small cell lung cancer_Homo sapiens_hsa052221.06157305
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06128782
54Toxoplasmosis_Homo sapiens_hsa051451.03447694
55Prolactin signaling pathway_Homo sapiens_hsa049171.02968005
56Staphylococcus aureus infection_Homo sapiens_hsa051501.02313863
57Allograft rejection_Homo sapiens_hsa053301.02282216
58Antigen processing and presentation_Homo sapiens_hsa046121.00523438
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.97770629
60Viral carcinogenesis_Homo sapiens_hsa052030.95909227
61Ovarian steroidogenesis_Homo sapiens_hsa049130.95067370
62Graft-versus-host disease_Homo sapiens_hsa053320.94222844
63Colorectal cancer_Homo sapiens_hsa052100.94046986
64Acute myeloid leukemia_Homo sapiens_hsa052210.93953218
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91582622
66Notch signaling pathway_Homo sapiens_hsa043300.90327356
67mRNA surveillance pathway_Homo sapiens_hsa030150.90187593
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90184906
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.88501415
70Tuberculosis_Homo sapiens_hsa051520.87619059
71Other glycan degradation_Homo sapiens_hsa005110.86857284
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86544237
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85486185
74Spliceosome_Homo sapiens_hsa030400.85309123
75HTLV-I infection_Homo sapiens_hsa051660.83627036
76Pertussis_Homo sapiens_hsa051330.82891203
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80826182
78Folate biosynthesis_Homo sapiens_hsa007900.79078664
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78357723
80Non-homologous end-joining_Homo sapiens_hsa034500.78308111
81African trypanosomiasis_Homo sapiens_hsa051430.77972854
82Ether lipid metabolism_Homo sapiens_hsa005650.76602355
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76431198
84Platelet activation_Homo sapiens_hsa046110.76373729
85Circadian rhythm_Homo sapiens_hsa047100.76065549
86Non-small cell lung cancer_Homo sapiens_hsa052230.73277133
87VEGF signaling pathway_Homo sapiens_hsa043700.72768846
88FoxO signaling pathway_Homo sapiens_hsa040680.72385741
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71399185
90TGF-beta signaling pathway_Homo sapiens_hsa043500.70460524
91Renal cell carcinoma_Homo sapiens_hsa052110.68751899
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67933663
93Hematopoietic cell lineage_Homo sapiens_hsa046400.67929585
94Thyroid cancer_Homo sapiens_hsa052160.67883172
95Oocyte meiosis_Homo sapiens_hsa041140.67812894
96Bladder cancer_Homo sapiens_hsa052190.67412632
97Regulation of autophagy_Homo sapiens_hsa041400.65012654
98Hepatitis C_Homo sapiens_hsa051600.64904968
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64259835
100Viral myocarditis_Homo sapiens_hsa054160.63614607
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63090644
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61746511
103Asthma_Homo sapiens_hsa053100.60499769
104Chemokine signaling pathway_Homo sapiens_hsa040620.58379345
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58376384
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.56933660
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.56716307
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56048417
109Dorso-ventral axis formation_Homo sapiens_hsa043200.55267020
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54979521
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54971321
112Linoleic acid metabolism_Homo sapiens_hsa005910.53844469
113Selenocompound metabolism_Homo sapiens_hsa004500.50169559
114Endocytosis_Homo sapiens_hsa041440.50066597
115Sulfur relay system_Homo sapiens_hsa041220.49490238
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.49398317
117Prostate cancer_Homo sapiens_hsa052150.49277299
118Systemic lupus erythematosus_Homo sapiens_hsa053220.48062870
119HIF-1 signaling pathway_Homo sapiens_hsa040660.48035959
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46851035
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46713085
122T cell receptor signaling pathway_Homo sapiens_hsa046600.43336463
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42632920
124Endometrial cancer_Homo sapiens_hsa052130.42147918
125Adherens junction_Homo sapiens_hsa045200.41487080
126Insulin resistance_Homo sapiens_hsa049310.38789403
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37453731
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36150838
129Galactose metabolism_Homo sapiens_hsa000520.33377281
130Collecting duct acid secretion_Homo sapiens_hsa049660.30691938
131Pentose phosphate pathway_Homo sapiens_hsa000300.30221209
132Fructose and mannose metabolism_Homo sapiens_hsa000510.28564452
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23493549
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.22693561
135Amoebiasis_Homo sapiens_hsa051460.19417187
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18636328
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.18206928
138MAPK signaling pathway_Homo sapiens_hsa040100.18156408
139Type II diabetes mellitus_Homo sapiens_hsa049300.12256547

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