MTMR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin metabolic process (GO:0006582)8.18292959
2melanin biosynthetic process (GO:0042438)7.81696679
3secondary metabolite biosynthetic process (GO:0044550)6.34476110
4nuclear pore complex assembly (GO:0051292)4.82464496
5nuclear pore organization (GO:0006999)4.41681926
6cullin deneddylation (GO:0010388)4.12966354
7COPI coating of Golgi vesicle (GO:0048205)4.11441485
8Golgi transport vesicle coating (GO:0048200)4.11441485
9establishment of integrated proviral latency (GO:0075713)3.93716137
10protein localization to kinetochore (GO:0034501)3.90386219
11myelin maintenance (GO:0043217)3.89638343
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.86399428
13protein deneddylation (GO:0000338)3.84958924
14kinetochore organization (GO:0051383)3.79793588
15pore complex assembly (GO:0046931)3.73999415
16double-strand break repair via nonhomologous end joining (GO:0006303)3.61113287
17non-recombinational repair (GO:0000726)3.61113287
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.54611525
19histone exchange (GO:0043486)3.49628468
20regulation of DNA endoreduplication (GO:0032875)3.48857483
21kinetochore assembly (GO:0051382)3.38613173
22DNA ligation (GO:0006266)3.36760696
23positive regulation of cell cycle checkpoint (GO:1901978)3.36681221
24proteasome assembly (GO:0043248)3.36112207
25dosage compensation (GO:0007549)3.32255799
26axon ensheathment in central nervous system (GO:0032291)3.29079188
27central nervous system myelination (GO:0022010)3.29079188
28regulation of protein polyubiquitination (GO:1902914)3.27677017
29microtubule depolymerization (GO:0007019)3.19829162
30protein localization to chromosome, centromeric region (GO:0071459)3.15565771
31centrosome duplication (GO:0051298)3.07059791
32sister chromatid segregation (GO:0000819)3.04323187
33regulation of sister chromatid cohesion (GO:0007063)3.04172066
34ribosome assembly (GO:0042255)3.04155645
35establishment of viral latency (GO:0019043)3.02067318
36DNA replication-independent nucleosome assembly (GO:0006336)3.01360848
37DNA replication-independent nucleosome organization (GO:0034724)3.01360848
38DNA double-strand break processing (GO:0000729)2.99284812
39negative regulation of chromosome segregation (GO:0051985)2.99205248
40muscle cell migration (GO:0014812)2.99171805
41negative regulation of neurotransmitter secretion (GO:0046929)2.98834457
42regulation of centriole replication (GO:0046599)2.97777223
43cellular response to hepatocyte growth factor stimulus (GO:0035729)2.97674114
44response to hepatocyte growth factor (GO:0035728)2.97674114
45negative regulation of mitotic sister chromatid separation (GO:2000816)2.97638229
46negative regulation of sister chromatid segregation (GO:0033046)2.97638229
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97638229
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97638229
49negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97638229
50ventricular cardiac muscle cell development (GO:0055015)2.97540066
51mitotic spindle organization (GO:0007052)2.96526572
52resolution of meiotic recombination intermediates (GO:0000712)2.92736387
53protein refolding (GO:0042026)2.92587669
54mitotic sister chromatid cohesion (GO:0007064)2.92174012
55positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.89121006
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88902056
57regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88902056
58establishment of mitotic spindle orientation (GO:0000132)2.88363744
59mitotic spindle assembly checkpoint (GO:0007094)2.88166040
60developmental pigmentation (GO:0048066)2.88140496
61spindle assembly checkpoint (GO:0071173)2.87211866
62spindle checkpoint (GO:0031577)2.86519852
63ensheathment of neurons (GO:0007272)2.85925938
64axon ensheathment (GO:0008366)2.85925938
65myoblast migration (GO:0051451)2.85347128
66negative regulation of DNA repair (GO:0045738)2.84427798
67attachment of spindle microtubules to kinetochore (GO:0008608)2.84207329
68paraxial mesoderm development (GO:0048339)2.84147588
69mitotic metaphase plate congression (GO:0007080)2.82821347
70DNA strand elongation involved in DNA replication (GO:0006271)2.82329646
71myelination (GO:0042552)2.81898291
72regulation of sister chromatid segregation (GO:0033045)2.78934315
73regulation of mitotic sister chromatid separation (GO:0010965)2.78934315
74regulation of mitotic sister chromatid segregation (GO:0033047)2.78934315
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76350830
76mitotic nuclear envelope disassembly (GO:0007077)2.74491076
77bone remodeling (GO:0046849)2.74213154
78DNA strand elongation (GO:0022616)2.74017016
79phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.73879127
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73331590
81secondary metabolic process (GO:0019748)2.73226187
82establishment of mitotic spindle localization (GO:0040001)2.73177072
83cellular response to gamma radiation (GO:0071480)2.73153937
84hepatocyte apoptotic process (GO:0097284)2.72488581
85establishment of chromosome localization (GO:0051303)2.72182151
86response to lipoprotein particle (GO:0055094)2.67930545
87ear development (GO:0043583)2.67489944
88pigment biosynthetic process (GO:0046148)2.67480528
89regulation of protein heterodimerization activity (GO:0043497)2.66357594
90DNA replication checkpoint (GO:0000076)2.65933908
91positive regulation of actin filament depolymerization (GO:0030836)2.65750421
92protein localization to chromosome (GO:0034502)2.64367227
93CENP-A containing nucleosome assembly (GO:0034080)2.63215566
94neurofilament cytoskeleton organization (GO:0060052)2.62752395
95regulation of integrin-mediated signaling pathway (GO:2001044)2.61379717
96negative regulation of histone acetylation (GO:0035067)2.61291849
97cholesterol biosynthetic process (GO:0006695)2.61005510
98tRNA aminoacylation for protein translation (GO:0006418)2.60970546
99DNA unwinding involved in DNA replication (GO:0006268)2.60649499
100protein K6-linked ubiquitination (GO:0085020)2.59751240
101membrane disassembly (GO:0030397)2.59721569
102nuclear envelope disassembly (GO:0051081)2.59721569
103spindle assembly involved in mitosis (GO:0090307)2.59309902
104regulation of osteoblast proliferation (GO:0033688)2.59260205
105protein K11-linked deubiquitination (GO:0035871)2.58844001
106regulation of spindle organization (GO:0090224)2.58790687
107peripheral nervous system axon ensheathment (GO:0032292)2.58724930
108myelination in peripheral nervous system (GO:0022011)2.58724930
109mesenchymal-epithelial cell signaling (GO:0060638)2.56377758
110mitotic spindle checkpoint (GO:0071174)2.55465889
111negative regulation of DNA-dependent DNA replication (GO:2000104)2.54232245
112protein K48-linked deubiquitination (GO:0071108)2.52694038
113telomere maintenance via semi-conservative replication (GO:0032201)2.52455280
114regulation of spindle checkpoint (GO:0090231)2.51932215
115negative regulation of JUN kinase activity (GO:0043508)2.51850803
116protein complex localization (GO:0031503)2.51674911
117amino acid activation (GO:0043038)2.51537043
118tRNA aminoacylation (GO:0043039)2.51537043
119mitotic cytokinesis (GO:0000281)2.51040795
120phenol-containing compound biosynthetic process (GO:0046189)2.50583754
121ATP-dependent chromatin remodeling (GO:0043044)2.49004238
122centriole replication (GO:0007099)2.48337232
123response to X-ray (GO:0010165)2.47743443
124cranial suture morphogenesis (GO:0060363)2.47717394
125chromatin remodeling at centromere (GO:0031055)2.47123634
126microtubule polymerization or depolymerization (GO:0031109)2.46949520
127cytoskeleton-dependent cytokinesis (GO:0061640)2.46598297
128melanosome organization (GO:0032438)2.46584714
129replicative senescence (GO:0090399)2.44950699
130positive regulation of chromosome segregation (GO:0051984)2.44853206
131glucocorticoid receptor signaling pathway (GO:0042921)2.44207244
132metaphase plate congression (GO:0051310)2.43932769
133apical protein localization (GO:0045176)2.43035990
134astrocyte development (GO:0014002)2.42878173
135positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.41941724
136regulation of double-strand break repair (GO:2000779)2.41174356
137melanocyte differentiation (GO:0030318)2.40731811
138regulation of cell maturation (GO:1903429)2.40390579
139regulation of mitotic spindle organization (GO:0060236)2.40014714
140mitotic cell cycle (GO:0000278)2.39057484
141synapsis (GO:0007129)2.38939915
142microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.38702842
143negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.37842262
144regulation of centrosome duplication (GO:0010824)2.37680752
145regulation of mitotic spindle checkpoint (GO:1903504)2.37231806
146regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37231806
147mitotic G2/M transition checkpoint (GO:0044818)2.36283713
148regulation of RNA export from nucleus (GO:0046831)2.36170740
149DNA catabolic process, exonucleolytic (GO:0000738)2.34684102
150mitotic G2 DNA damage checkpoint (GO:0007095)2.34603490
151Rap protein signal transduction (GO:0032486)2.33311405
152pigment cell differentiation (GO:0050931)2.33249665
153iron ion import (GO:0097286)2.31447316
154tyrosine metabolic process (GO:0006570)2.31265270
155radial glial cell differentiation (GO:0060019)2.30377913
156mitotic chromosome condensation (GO:0007076)2.30171366
157mesodermal cell differentiation (GO:0048333)2.29828598
158hippo signaling (GO:0035329)2.29804013
159centrosome organization (GO:0051297)2.29514237
160mitotic sister chromatid segregation (GO:0000070)2.29503440
161chromosome segregation (GO:0007059)2.29268227
162maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.26297134
163regulation of chromosome segregation (GO:0051983)2.25866471
164regulation of centrosome cycle (GO:0046605)2.25381342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.98023732
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.60628661
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.42639601
4AR_21909140_ChIP-Seq_LNCAP_Human3.29110920
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.19353966
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.14667845
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11389505
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93492234
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.80130146
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74072524
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.72932924
12PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.33951253
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31919750
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.24582806
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.23071935
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.14112278
17* ELK1_19687146_ChIP-ChIP_HELA_Human2.13084251
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.05819871
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02677827
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89905993
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87103452
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83637897
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.80625720
24* FUS_26573619_Chip-Seq_HEK293_Human1.78358578
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72516514
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70927128
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70901178
28DCP1A_22483619_ChIP-Seq_HELA_Human1.61182591
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58328017
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54511716
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53991441
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53304722
33* BRD4_25478319_ChIP-Seq_HGPS_Human1.53219486
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.52503084
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52318741
36IGF1R_20145208_ChIP-Seq_DFB_Human1.50273705
37SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48558081
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.48324756
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48311058
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48136069
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47915578
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47915578
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47391688
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47201539
45* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45286142
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42498391
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41844036
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39296992
49* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.38001652
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37779711
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37760774
52CLOCK_20551151_ChIP-Seq_293T_Human1.37216502
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34385200
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32876018
55TFEB_21752829_ChIP-Seq_HELA_Human1.32788848
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32440558
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30317102
58TAF15_26573619_Chip-Seq_HEK293_Human1.30166474
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29856034
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28323282
61SOX17_20123909_ChIP-Seq_XEN_Mouse1.27114509
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25855656
63P300_19829295_ChIP-Seq_ESCs_Human1.25825220
64MYC_18940864_ChIP-ChIP_HL60_Human1.21446316
65FOXP3_21729870_ChIP-Seq_TREG_Human1.20679629
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20599964
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19780425
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19319374
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19254928
70* GABP_19822575_ChIP-Seq_HepG2_Human1.18526865
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17930226
72* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17449077
73TTF2_22483619_ChIP-Seq_HELA_Human1.15580047
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.15437943
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.12934516
76EWS_26573619_Chip-Seq_HEK293_Human1.12119869
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11194314
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10474107
79* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10212909
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09094078
81* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08935922
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08908623
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08088722
84CJUN_26792858_Chip-Seq_BT549_Human1.07842170
85CHD1_26751641_Chip-Seq_LNCaP_Human1.07532943
86* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07449738
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06931255
88PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.05989570
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05918987
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05598239
91GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05528997
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05124075
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04141684
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04141684
95IRF8_22096565_ChIP-ChIP_GC-B_Human1.03950879
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02918788
97MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01947549
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00752127
99SOX9_26525672_Chip-Seq_HEART_Mouse1.00523006
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99783384
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98798402
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98134826
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95781849
104GBX2_23144817_ChIP-Seq_PC3_Human0.95204772
105SRF_21415370_ChIP-Seq_HL-1_Mouse0.94784738
106* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93663967
107* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93579215
108MYC_18555785_ChIP-Seq_MESCs_Mouse0.93389607
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93262454
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92674214
111ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91886159
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91786963
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90877918
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.90040853
115GABP_17652178_ChIP-ChIP_JURKAT_Human0.89832253
116* GATA2_21666600_ChIP-Seq_HMVEC_Human0.89685755
117SMAD3_21741376_ChIP-Seq_EPCs_Human0.88028565
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.87468361
119JUN_21703547_ChIP-Seq_K562_Human0.86334639
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85383748
121E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85304228
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85020673
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84795241
124SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.84652275
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84229018
126SMAD_19615063_ChIP-ChIP_OVARY_Human0.84222916
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84065840
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83771595
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83597828
130* UBF1/2_26484160_Chip-Seq_HMECs_Human0.83158443
131XRN2_22483619_ChIP-Seq_HELA_Human0.82808322
132FLI1_27457419_Chip-Seq_LIVER_Mouse0.82762227
133NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82044040
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81065000
135SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80943985
136STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80790848
137* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79607240
138* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78727308
139PKCTHETA_26484144_Chip-Seq_BREAST_Human0.78667363
140SMAD4_21799915_ChIP-Seq_A2780_Human0.77767355
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77585880
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77565306
143VDR_23849224_ChIP-Seq_CD4+_Human0.77467417
144MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.76632539
145* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75028444
146KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74297289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation6.71321623
2MP0005171_absent_coat_pigmentation5.69407977
3MP0005408_hypopigmentation5.05283014
4MP0002877_abnormal_melanocyte_morpholog3.58262742
5MP0002102_abnormal_ear_morphology2.99366694
6MP0008438_abnormal_cutaneous_collagen2.88075401
7MP0003136_yellow_coat_color2.58607446
8MP0003950_abnormal_plasma_membrane2.51415118
9MP0006054_spinal_hemorrhage2.43203603
10MP0008007_abnormal_cellular_replicative2.26099248
11MP0000371_diluted_coat_color2.17074518
12MP0008058_abnormal_DNA_repair2.13113865
13MP0000015_abnormal_ear_pigmentation2.02401679
14MP0003890_abnormal_embryonic-extraembry2.02248169
15MP0010094_abnormal_chromosome_stability1.97724133
16MP0003806_abnormal_nucleotide_metabolis1.89977384
17MP0001348_abnormal_lacrimal_gland1.89645511
18MP0002095_abnormal_skin_pigmentation1.80520502
19MP0010307_abnormal_tumor_latency1.74354107
20MP0002009_preneoplasia1.72615076
21MP0004381_abnormal_hair_follicle1.62019421
22* MP0000920_abnormal_myelination1.58113860
23MP0003937_abnormal_limbs/digits/tail_de1.57731204
24MP0003941_abnormal_skin_development1.54488711
25MP0005623_abnormal_meninges_morphology1.54074118
26MP0005075_abnormal_melanosome_morpholog1.51254845
27MP0008932_abnormal_embryonic_tissue1.50973198
28MP0000569_abnormal_digit_pigmentation1.46204563
29MP0003077_abnormal_cell_cycle1.45864852
30MP0002075_abnormal_coat/hair_pigmentati1.44063626
31MP0001186_pigmentation_phenotype1.38581730
32MP0005257_abnormal_intraocular_pressure1.36330521
33MP0003943_abnormal_hepatobiliary_system1.34570279
34MP0010352_gastrointestinal_tract_polyps1.33128982
35MP0001324_abnormal_eye_pigmentation1.31751047
36MP0002090_abnormal_vision1.31455604
37MP0005248_abnormal_Harderian_gland1.29494034
38MP0001299_abnormal_eye_distance/1.29108466
39MP0002938_white_spotting1.26390765
40MP0005174_abnormal_tail_pigmentation1.25473001
41MP0008057_abnormal_DNA_replication1.19660499
42MP0004885_abnormal_endolymph1.19216237
43MP0010030_abnormal_orbit_morphology1.18524116
44MP0002177_abnormal_outer_ear1.17684120
45MP0004272_abnormal_basement_membrane1.16882744
46MP0001730_embryonic_growth_arrest1.12870546
47MP0005503_abnormal_tendon_morphology1.11904254
48MP0001293_anophthalmia1.08731558
49MP0005197_abnormal_uvea_morphology1.08514536
50MP0003186_abnormal_redox_activity1.08502728
51MP0003111_abnormal_nucleus_morphology1.08351420
52MP0001529_abnormal_vocalization1.08252556
53MP0002822_catalepsy1.07742598
54MP0001879_abnormal_lymphatic_vessel1.07694685
55MP0003942_abnormal_urinary_system1.06509854
56MP0002160_abnormal_reproductive_system1.05842451
57MP0005187_abnormal_penis_morphology1.05545594
58MP0004957_abnormal_blastocyst_morpholog1.05375327
59MP0003567_abnormal_fetal_cardiomyocyte1.04431744
60MP0008877_abnormal_DNA_methylation1.04134941
61MP0000733_abnormal_muscle_development1.03620925
62MP0000350_abnormal_cell_proliferation1.03355072
63MP0003705_abnormal_hypodermis_morpholog1.01213377
64MP0003091_abnormal_cell_migration1.00144644
65MP0000428_abnormal_craniofacial_morphol0.97975390
66MP0000432_abnormal_head_morphology0.96964560
67MP0000647_abnormal_sebaceous_gland0.96900556
68MP0003693_abnormal_embryo_hatching0.96654511
69MP0003123_paternal_imprinting0.96364938
70MP0009250_abnormal_appendicular_skeleto0.96228454
71MP0001915_intracranial_hemorrhage0.95675704
72MP0004233_abnormal_muscle_weight0.94164120
73MP0004197_abnormal_fetal_growth/weight/0.93169666
74MP0003119_abnormal_digestive_system0.93153154
75MP0005253_abnormal_eye_physiology0.92493134
76MP0003453_abnormal_keratinocyte_physiol0.91639259
77MP0001177_atelectasis0.91556593
78MP0001697_abnormal_embryo_size0.90836331
79MP0002638_abnormal_pupillary_reflex0.90312990
80MP0000358_abnormal_cell_content/0.89759928
81MP0001672_abnormal_embryogenesis/_devel0.88162375
82MP0005380_embryogenesis_phenotype0.88162375
83MP0003755_abnormal_palate_morphology0.87644713
84MP0010678_abnormal_skin_adnexa0.87303471
85MP0005023_abnormal_wound_healing0.87201928
86* MP0002080_prenatal_lethality0.87085542
87MP0000537_abnormal_urethra_morphology0.86415362
88MP0001286_abnormal_eye_development0.85204543
89MP0004134_abnormal_chest_morphology0.84490944
90MP0002085_abnormal_embryonic_tissue0.84404317
91MP0001849_ear_inflammation0.83678419
92MP0002697_abnormal_eye_size0.81497501
93MP0003984_embryonic_growth_retardation0.80567856
94MP0001984_abnormal_olfaction0.80324925
95MP0000534_abnormal_ureter_morphology0.80284308
96MP0004782_abnormal_surfactant_physiolog0.80141244
97MP0002092_abnormal_eye_morphology0.79608940
98MP0002084_abnormal_developmental_patter0.79396184
99MP0003121_genomic_imprinting0.78591408
100MP0005391_vision/eye_phenotype0.78458331
101MP0003632_abnormal_nervous_system0.78123133
102MP0010368_abnormal_lymphatic_system0.76888799
103MP0002088_abnormal_embryonic_growth/wei0.74925927
104MP0002233_abnormal_nose_morphology0.74103548
105MP0002168_other_aberrant_phenotype0.73762090
106MP0000427_abnormal_hair_cycle0.73225405
107MP0009697_abnormal_copulation0.73188131
108MP0010234_abnormal_vibrissa_follicle0.73147457
109MP0005395_other_phenotype0.72623610
110MP0002751_abnormal_autonomic_nervous0.71995298
111MP0003566_abnormal_cell_adhesion0.70913774
112MP0009672_abnormal_birth_weight0.70883250
113MP0005508_abnormal_skeleton_morphology0.70809773
114MP0003718_maternal_effect0.70773104
115MP0004147_increased_porphyrin_level0.70315742
116MP0005275_abnormal_skin_tensile0.69811949
117MP0005193_abnormal_anterior_eye0.69779972
118MP0000566_synostosis0.69211012
119MP0003385_abnormal_body_wall0.69178319
120MP0002111_abnormal_tail_morphology0.68561173
121MP0004215_abnormal_myocardial_fiber0.67514263
122MP0002115_abnormal_skeleton_extremities0.67059012
123MP0006138_congestive_heart_failure0.66349541
124MP0005409_darkened_coat_color0.64754050
125MP0003634_abnormal_glial_cell0.64536583
126MP0006072_abnormal_retinal_apoptosis0.64032279
127MP0002086_abnormal_extraembryonic_tissu0.63716168
128MP0000163_abnormal_cartilage_morphology0.63486619
129MP0003786_premature_aging0.63392037
130MP0009703_decreased_birth_body0.62725748
131MP0003935_abnormal_craniofacial_develop0.62418752
132MP0002210_abnormal_sex_determination0.62334909
133MP0003861_abnormal_nervous_system0.60205272
134MP0008789_abnormal_olfactory_epithelium0.58666658
135MP0005384_cellular_phenotype0.56555763

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the macula (HP:0008059)4.63280521
2Aplasia/Hypoplasia affecting the retina (HP:0008061)4.37727213
3Aplasia/Hypoplasia of the fovea (HP:0008060)4.31555843
4Hypoplasia of the fovea (HP:0007750)4.31555843
5Cutaneous melanoma (HP:0012056)4.15477407
6Degeneration of the lateral corticospinal tracts (HP:0002314)3.84013766
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.84013766
8Subacute progressive viral hepatitis (HP:0006572)3.54677616
9Abnormality of the fovea (HP:0000493)3.47438695
10Selective tooth agenesis (HP:0001592)3.45698184
11Hypopigmentation of the fundus (HP:0007894)3.41600026
12Blue irides (HP:0000635)3.33957799
13Premature rupture of membranes (HP:0001788)3.01344829
14Segmental peripheral demyelination/remyelination (HP:0003481)2.96761777
15Cortical dysplasia (HP:0002539)2.89795730
16Syringomyelia (HP:0003396)2.79573079
17Spinal cord lesions (HP:0100561)2.79573079
18Increased nuchal translucency (HP:0010880)2.78205568
19White forelock (HP:0002211)2.69522175
20Papillary thyroid carcinoma (HP:0002895)2.65672850
21Freckling (HP:0001480)2.53330886
22Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.53202106
23Patchy hypopigmentation of hair (HP:0011365)2.52707848
24Duodenal stenosis (HP:0100867)2.47894485
25Small intestinal stenosis (HP:0012848)2.47894485
26Facial cleft (HP:0002006)2.46486860
27Bifid tongue (HP:0010297)2.42253894
28Ectopic kidney (HP:0000086)2.39446635
29Abnormality of the frontal sinuses (HP:0002687)2.38245184
30Asymmetry of the thorax (HP:0001555)2.37526120
31Generalized hypopigmentation (HP:0007513)2.32443649
32Meckel diverticulum (HP:0002245)2.29616379
33Absent frontal sinuses (HP:0002688)2.28574287
34Abnormality of glycolysis (HP:0004366)2.28316864
35* Abnormal auditory evoked potentials (HP:0006958)2.27124066
36Neoplasm of the adrenal cortex (HP:0100641)2.27117224
37Abnormality of dentin (HP:0010299)2.26838080
38Bilateral sensorineural hearing impairment (HP:0008619)2.26447406
39Upper limb muscle weakness (HP:0003484)2.26213605
40Relative macrocephaly (HP:0004482)2.24497727
41Short nail (HP:0001799)2.23985061
42Sensory axonal neuropathy (HP:0003390)2.22212205
43Soft skin (HP:0000977)2.21829157
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.19493815
45Abnormality of the ileum (HP:0001549)2.19126198
46Abnormality of the duodenum (HP:0002246)2.13145567
47Abnormality of the corticospinal tract (HP:0002492)2.12638823
48Heterochromia iridis (HP:0001100)2.12469555
49Median cleft lip (HP:0000161)2.12014632
50Proximal placement of thumb (HP:0009623)2.11266765
51Long clavicles (HP:0000890)2.10122783
52Thyroid carcinoma (HP:0002890)2.09358680
53Abnormality of the anterior horn cell (HP:0006802)2.08900746
54Degeneration of anterior horn cells (HP:0002398)2.08900746
55Deviation of the thumb (HP:0009603)2.06914597
56Ocular albinism (HP:0001107)2.04156369
57Fibular hypoplasia (HP:0003038)2.03918660
58Termporal pattern (HP:0011008)2.03559519
59Insidious onset (HP:0003587)2.03559519
60Osteolytic defects of the hand bones (HP:0009699)2.02169578
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.02169578
62Wormian bones (HP:0002645)2.01035422
63Nephroblastoma (Wilms tumor) (HP:0002667)1.99800907
64Astigmatism (HP:0000483)1.99172089
65Broad face (HP:0000283)1.98564562
66Hypoplasia of the iris (HP:0007676)1.98537004
67Prominent occiput (HP:0000269)1.98209850
68Abnormality of the distal phalanx of the thumb (HP:0009617)1.97173403
69Abnormality of the peritoneum (HP:0002585)1.96933351
70Premature graying of hair (HP:0002216)1.96797154
71Chromsome breakage (HP:0040012)1.92679472
72Overgrowth (HP:0001548)1.92491943
73Protrusio acetabuli (HP:0003179)1.91818256
74Albinism (HP:0001022)1.88508520
75Embryonal renal neoplasm (HP:0011794)1.87501651
76Aortic regurgitation (HP:0001659)1.87118011
77Abnormality of the labia minora (HP:0012880)1.86616334
78Increased serum pyruvate (HP:0003542)1.86345748
79Carpal bone hypoplasia (HP:0001498)1.86134610
80Abnormality of the nasal septum (HP:0000419)1.86040301
81Stridor (HP:0010307)1.85397286
82Bell-shaped thorax (HP:0001591)1.85307003
83Adrenal hypoplasia (HP:0000835)1.84679310
84Flared iliac wings (HP:0002869)1.83998664
85Micronodular cirrhosis (HP:0001413)1.83995258
86Shallow orbits (HP:0000586)1.83282994
87Cervical subluxation (HP:0003308)1.82422244
88Diastasis recti (HP:0001540)1.82019481
89Short tibia (HP:0005736)1.81461484
90Neoplasm of the peripheral nervous system (HP:0100007)1.80734887
91Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.79912163
92Congenital sensorineural hearing impairment (HP:0008527)1.79578601
93Sloping forehead (HP:0000340)1.79333498
94Broad distal phalanx of finger (HP:0009836)1.78718288
95Aqueductal stenosis (HP:0002410)1.77745195
96Stenosis of the external auditory canal (HP:0000402)1.77395118
97Abnormality of the preputium (HP:0100587)1.75827727
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75150280
99Short 4th metacarpal (HP:0010044)1.75150280
100Astrocytoma (HP:0009592)1.74902562
101Abnormality of the astrocytes (HP:0100707)1.74902562
102Ependymoma (HP:0002888)1.73034575
103Microglossia (HP:0000171)1.72705978
104Supernumerary spleens (HP:0009799)1.71528743
105Melanoma (HP:0002861)1.70473670
106Horizontal nystagmus (HP:0000666)1.69808747
107Autoamputation (HP:0001218)1.69726375
108Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.69364918
109Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68950353
110Acute myeloid leukemia (HP:0004808)1.68375266
111Deep philtrum (HP:0002002)1.67682602
112Aplasia/Hypoplasia of the fibula (HP:0006492)1.67318495
113Neoplasm of the colon (HP:0100273)1.66337258
114Intestinal atresia (HP:0011100)1.65529318
115Stillbirth (HP:0003826)1.63685081
116Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63559123
117Abnormality of methionine metabolism (HP:0010901)1.63332583
118Central scotoma (HP:0000603)1.62811498
119Abnormality of incisor morphology (HP:0011063)1.62529945
120Atrophic scars (HP:0001075)1.62160145
121Glioma (HP:0009733)1.61646155
122Cystic hygroma (HP:0000476)1.61187483
123Macroorchidism (HP:0000053)1.59500507
124Tongue fasciculations (HP:0001308)1.58403409
125Abnormal lung lobation (HP:0002101)1.58119841
126Abnormality of the phalanges of the hallux (HP:0010057)1.57539282
127Rhabdomyosarcoma (HP:0002859)1.56767206
128Postnatal microcephaly (HP:0005484)1.56725139
129Aplasia/Hypoplasia of the tibia (HP:0005772)1.56277980
130Absent radius (HP:0003974)1.55134942
131Aortic dissection (HP:0002647)1.54683138
132Preaxial hand polydactyly (HP:0001177)1.54415192
133Alacrima (HP:0000522)1.53918294
134Neuroendocrine neoplasm (HP:0100634)1.53138655
135Dyschromatopsia (HP:0007641)1.53105274
136Abnormal foot bone ossification (HP:0010675)1.52904558
137Leiomyosarcoma (HP:0100243)1.52740180
138Uterine leiomyosarcoma (HP:0002891)1.52740180
139Gastrointestinal atresia (HP:0002589)1.51336712
140Ankle contracture (HP:0006466)1.49834097
141Abnormality of chromosome stability (HP:0003220)1.49705896
142Ulnar claw (HP:0001178)1.49674689
143Abnormal umbilical cord blood vessels (HP:0011403)1.49599979
144Single umbilical artery (HP:0001195)1.49599979
145Abnormality of the fetal cardiovascular system (HP:0010948)1.49599979
146Transitional cell carcinoma of the bladder (HP:0006740)1.49544357
147Abnormality of the carotid arteries (HP:0005344)1.48134173
148Pheochromocytoma (HP:0002666)1.47826640
149Stomach cancer (HP:0012126)1.47773442
150Onion bulb formation (HP:0003383)1.47311508
151Meningioma (HP:0002858)1.47182322
152Vertebral compression fractures (HP:0002953)1.46520177
153Atrophy/Degeneration involving motor neurons (HP:0007373)1.46208406
154Volvulus (HP:0002580)1.46009150
155Reduced antithrombin III activity (HP:0001976)1.45635662
156Myelodysplasia (HP:0002863)1.45316113
157Viral hepatitis (HP:0006562)1.45067029
158Iris hypopigmentation (HP:0007730)1.44867287
159Abnormal vertebral ossification (HP:0100569)1.44679543
160Absent forearm bone (HP:0003953)1.44100977
161Aplasia involving forearm bones (HP:0009822)1.44100977
162Hypoplastic pelvis (HP:0008839)1.43414392
163Poor head control (HP:0002421)1.43379592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.76627149
2PRPF4B4.61728318
3TRIM283.62013920
4MST1R3.34594252
5MET3.27929735
6MKNK12.64990255
7STK392.36507888
8SCYL22.26584166
9STK32.23397113
10FRK2.16305222
11TSSK62.11924172
12BRSK22.05087492
13CDC72.01502816
14PDK21.99518246
15NUAK11.97286930
16MARK31.94041206
17WEE11.87841434
18NEK91.82725838
19ZAK1.79099093
20MST41.74983055
21ERBB31.67125986
22PLK31.59517733
23TRPM71.55181467
24FGFR21.53774364
25WNK31.45710890
26EPHA31.45303970
27BCR1.45181565
28BMX1.44791093
29BMPR1B1.42080015
30SRPK11.40877673
31OXSR11.38366032
32ACVR1B1.36524349
33LIMK11.36055281
34TESK21.33459587
35YES11.33281370
36STK41.28794087
37MAP3K121.26505141
38MKNK21.22304922
39NEK61.20968552
40CSNK1A1L1.18953963
41STK38L1.18284285
42PLK41.15674845
43PBK1.13837133
44STK161.13223823
45SGK2231.10087249
46SGK4941.10087249
47ERBB41.09116489
48DDR21.08374132
49WNK41.06590716
50SIK31.03837532
51SGK21.03739757
52CSNK1G11.01516880
53PIM10.96814667
54FER0.94951140
55WNK10.94740792
56CSNK1G30.90802247
57AKT30.90666274
58PNCK0.90578515
59EIF2AK30.90546217
60CDK60.88329164
61TTK0.86005568
62CHUK0.85747757
63MINK10.85008832
64MAP3K140.82801469
65TIE10.81273892
66PLK10.80917857
67EPHB10.80787592
68TNIK0.80403115
69TGFBR10.78118091
70FGFR30.74757447
71MAP4K20.74707885
72CHEK20.73433536
73CLK10.71431248
74MAP2K70.70126804
75SGK30.68017887
76MELK0.66774059
77PASK0.66542601
78BRSK10.66408273
79PRKG20.65845418
80NEK20.65759241
81TAF10.64635135
82ATR0.64081260
83STK100.63905071
84GSK3A0.62095655
85MAP3K80.62021457
86TESK10.61675993
87BRD40.61162930
88CDK180.60852431
89PLK20.60507405
90UHMK10.60448276
91RPS6KB20.59563702
92KSR10.59383721
93CDK140.58003356
94CDK70.56310603
95FGFR10.55743998
96MAPKAPK50.54600156
97CSNK1G20.50313186
98CHEK10.49343536
99ATM0.48185467
100VRK10.47818010
101CCNB10.47521128
102BRAF0.47354419
103RPS6KA40.47210286
104MAP3K40.47075611
105CDK150.46643331
106AURKB0.46612737
107EIF2AK20.46045098
108MYLK0.45999472
109CDK120.45733150
110STK240.44745008
111PAK30.42901462
112PAK40.42606050
113EIF2AK10.42510725
114EPHA20.42356598
115CDK11A0.42058477
116AURKA0.41078115
117CDK10.39893810
118PAK20.37880252
119PTK2B0.37620429
120BMPR20.37233097
121NLK0.37230524
122HIPK20.37103818
123CDK20.36234201
124LATS20.35845532
125AKT20.34414754
126CAMK2D0.34325140
127PAK10.33816741
128NEK10.33673299
129CDK30.32824397
130PDGFRB0.31800514
131NTRK10.31543507
132FLT30.30321753
133ROCK20.29681829
134BUB10.29028187
135RPS6KA50.28209485
136IKBKE0.27708740
137PTK60.27701700
138MAPK10.27567984
139PRKCG0.27287262
140PTK20.27129855
141CSNK2A10.26773658

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.91198501
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.80028457
3Cell cycle_Homo sapiens_hsa041102.60256121
4Steroid biosynthesis_Homo sapiens_hsa001002.17987630
5DNA replication_Homo sapiens_hsa030302.16225239
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.14822641
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10700399
8Protein export_Homo sapiens_hsa030602.02945690
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97698092
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89689321
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.85885050
12Basal transcription factors_Homo sapiens_hsa030221.81559136
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79306921
14Viral carcinogenesis_Homo sapiens_hsa052031.68991088
15Small cell lung cancer_Homo sapiens_hsa052221.64903910
16Mismatch repair_Homo sapiens_hsa034301.63452293
17MicroRNAs in cancer_Homo sapiens_hsa052061.62076006
18Base excision repair_Homo sapiens_hsa034101.60951945
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.60564011
20Prostate cancer_Homo sapiens_hsa052151.55162195
21Systemic lupus erythematosus_Homo sapiens_hsa053221.54789148
22RNA degradation_Homo sapiens_hsa030181.53665650
23Fatty acid elongation_Homo sapiens_hsa000621.53174349
24Thyroid cancer_Homo sapiens_hsa052161.45795042
25Adherens junction_Homo sapiens_hsa045201.43469912
26Non-homologous end-joining_Homo sapiens_hsa034501.43155270
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41788235
28Biosynthesis of amino acids_Homo sapiens_hsa012301.40891922
29Propanoate metabolism_Homo sapiens_hsa006401.39431594
30p53 signaling pathway_Homo sapiens_hsa041151.37451291
31One carbon pool by folate_Homo sapiens_hsa006701.37383892
32Nucleotide excision repair_Homo sapiens_hsa034201.36581772
33N-Glycan biosynthesis_Homo sapiens_hsa005101.31916902
34Fanconi anemia pathway_Homo sapiens_hsa034601.30873786
35Selenocompound metabolism_Homo sapiens_hsa004501.30782347
36Pyruvate metabolism_Homo sapiens_hsa006201.28679545
37Endometrial cancer_Homo sapiens_hsa052131.27525733
38Homologous recombination_Homo sapiens_hsa034401.26958211
39RNA transport_Homo sapiens_hsa030131.26749352
40ECM-receptor interaction_Homo sapiens_hsa045121.24960264
41TGF-beta signaling pathway_Homo sapiens_hsa043501.23823054
42Renal cell carcinoma_Homo sapiens_hsa052111.22207300
43Hippo signaling pathway_Homo sapiens_hsa043901.21587066
44Glutathione metabolism_Homo sapiens_hsa004801.21505702
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21432550
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20880757
47Tight junction_Homo sapiens_hsa045301.19974852
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17373669
49Shigellosis_Homo sapiens_hsa051311.15952771
50Focal adhesion_Homo sapiens_hsa045101.13491566
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11382632
52Carbon metabolism_Homo sapiens_hsa012001.11316288
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10928845
54Pancreatic cancer_Homo sapiens_hsa052121.10436124
55Colorectal cancer_Homo sapiens_hsa052101.08955283
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08301459
57Melanoma_Homo sapiens_hsa052181.07119323
58Alcoholism_Homo sapiens_hsa050341.06834560
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06423864
60Ether lipid metabolism_Homo sapiens_hsa005651.06167247
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05510923
62Chronic myeloid leukemia_Homo sapiens_hsa052201.03573588
63Sphingolipid metabolism_Homo sapiens_hsa006001.02249522
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01658660
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01433474
66Pyrimidine metabolism_Homo sapiens_hsa002401.00579230
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95756608
68Sulfur metabolism_Homo sapiens_hsa009200.93562021
69mRNA surveillance pathway_Homo sapiens_hsa030150.93395976
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92436933
71Proteoglycans in cancer_Homo sapiens_hsa052050.92369639
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89979805
73Epstein-Barr virus infection_Homo sapiens_hsa051690.88337878
74Pentose phosphate pathway_Homo sapiens_hsa000300.88065236
75Vitamin B6 metabolism_Homo sapiens_hsa007500.87697028
76Herpes simplex infection_Homo sapiens_hsa051680.86176678
77Spliceosome_Homo sapiens_hsa030400.85681889
78Purine metabolism_Homo sapiens_hsa002300.85032108
79Pathways in cancer_Homo sapiens_hsa052000.84872275
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84512497
81Hepatitis B_Homo sapiens_hsa051610.83225938
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82718350
83Vibrio cholerae infection_Homo sapiens_hsa051100.80268357
84Parkinsons disease_Homo sapiens_hsa050120.80180234
85Folate biosynthesis_Homo sapiens_hsa007900.79503790
86RNA polymerase_Homo sapiens_hsa030200.78297461
87Basal cell carcinoma_Homo sapiens_hsa052170.77528998
88Oocyte meiosis_Homo sapiens_hsa041140.77167007
89HTLV-I infection_Homo sapiens_hsa051660.77086003
90Wnt signaling pathway_Homo sapiens_hsa043100.76576320
91Malaria_Homo sapiens_hsa051440.74711447
92Salmonella infection_Homo sapiens_hsa051320.74235625
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72390613
94Huntingtons disease_Homo sapiens_hsa050160.71621908
95Prolactin signaling pathway_Homo sapiens_hsa049170.71135191
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67800331
97Fatty acid metabolism_Homo sapiens_hsa012120.67684022
98Measles_Homo sapiens_hsa051620.67636498
99Endocytosis_Homo sapiens_hsa041440.65581757
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64117962
101Ovarian steroidogenesis_Homo sapiens_hsa049130.64001485
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.60791389
103Tyrosine metabolism_Homo sapiens_hsa003500.60405668
104Axon guidance_Homo sapiens_hsa043600.59956166
105Oxidative phosphorylation_Homo sapiens_hsa001900.59944059
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59888470
107Apoptosis_Homo sapiens_hsa042100.59526099
108Ras signaling pathway_Homo sapiens_hsa040140.59491014
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59241567
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59055010
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57685500
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.57678971
113Collecting duct acid secretion_Homo sapiens_hsa049660.56699909
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.56523192
115FoxO signaling pathway_Homo sapiens_hsa040680.56218579
116Legionellosis_Homo sapiens_hsa051340.55393741
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.54974725
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54260000
119Toxoplasmosis_Homo sapiens_hsa051450.53778026
120Notch signaling pathway_Homo sapiens_hsa043300.53742067
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52389600
122Lysosome_Homo sapiens_hsa041420.49313985
123Non-small cell lung cancer_Homo sapiens_hsa052230.49198108
124Melanogenesis_Homo sapiens_hsa049160.47088584
125* Metabolic pathways_Homo sapiens_hsa011000.46485428
126Hedgehog signaling pathway_Homo sapiens_hsa043400.46139425
127Arginine and proline metabolism_Homo sapiens_hsa003300.44654323
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44288056
129Arachidonic acid metabolism_Homo sapiens_hsa005900.43745035
130Dorso-ventral axis formation_Homo sapiens_hsa043200.43220787
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42679788
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40377290
133Alzheimers disease_Homo sapiens_hsa050100.35816260
134Gap junction_Homo sapiens_hsa045400.35770047
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34212242
136beta-Alanine metabolism_Homo sapiens_hsa004100.33196374
137Fatty acid biosynthesis_Homo sapiens_hsa000610.30457720
138Circadian rhythm_Homo sapiens_hsa047100.29300541
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28384960
140Regulation of autophagy_Homo sapiens_hsa041400.26448549
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25032536

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