MTMR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of histone deacetylation (GO:0031065)4.61526300
2cellular extravasation (GO:0045123)4.53318330
3regulation of acrosome reaction (GO:0060046)4.30059382
4regulation of female gonad development (GO:2000194)4.23308810
5positive regulation of humoral immune response (GO:0002922)4.19557739
6positive regulation by symbiont of host defense response (GO:0052509)4.18153883
7modulation by symbiont of host defense response (GO:0052031)4.18153883
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18153883
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18153883
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.18153883
11modulation by symbiont of host immune response (GO:0052553)4.18153883
12negative regulation of cell killing (GO:0031342)4.11470651
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.11470651
14detection of other organism (GO:0098543)4.11367336
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10494344
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10494344
17positive regulation of gamma-delta T cell activation (GO:0046645)3.87973054
18response to peptidoglycan (GO:0032494)3.86143392
19detection of bacterium (GO:0016045)3.75819802
20macrophage activation involved in immune response (GO:0002281)3.70652129
21detection of molecule of bacterial origin (GO:0032490)3.69699892
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.69648138
23peptidyl-lysine dimethylation (GO:0018027)3.66774019
24antigen processing and presentation of endogenous antigen (GO:0019883)3.66125950
25regulation of gamma-delta T cell differentiation (GO:0045586)3.65828701
26protein kinase C signaling (GO:0070528)3.65190702
27protein localization to endosome (GO:0036010)3.63833365
28oocyte development (GO:0048599)3.53957912
29detection of external biotic stimulus (GO:0098581)3.53752150
30neutrophil activation involved in immune response (GO:0002283)3.52459308
31response to muramyl dipeptide (GO:0032495)3.45335096
32cytoplasmic mRNA processing body assembly (GO:0033962)3.36694774
33positive thymic T cell selection (GO:0045059)3.35738382
34regulation of mast cell degranulation (GO:0043304)3.31818713
35histone demethylation (GO:0016577)3.27660677
36cortical actin cytoskeleton organization (GO:0030866)3.27303624
37cytoskeletal anchoring at plasma membrane (GO:0007016)3.26516278
38leukocyte aggregation (GO:0070486)3.26362690
39antigen processing and presentation via MHC class Ib (GO:0002475)3.24431934
40histone H3-K4 trimethylation (GO:0080182)3.23674138
41response to host immune response (GO:0052572)3.22886258
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.22886258
43regulation of ARF GTPase activity (GO:0032312)3.21427226
44leukocyte migration involved in inflammatory response (GO:0002523)3.19680085
45regulation of gamma-delta T cell activation (GO:0046643)3.17921007
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14620932
47response to host (GO:0075136)3.14620932
48response to host defenses (GO:0052200)3.14620932
49natural killer cell differentiation (GO:0001779)3.14243693
50regulation of mast cell activation involved in immune response (GO:0033006)3.13430555
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.12239101
52negative regulation of interleukin-12 production (GO:0032695)3.11902772
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10877339
54multicellular organism reproduction (GO:0032504)3.10725626
55regulation of leukocyte degranulation (GO:0043300)3.09894805
56regulation of interleukin-12 biosynthetic process (GO:0045075)3.09292543
57receptor catabolic process (GO:0032801)3.07423759
58citrulline biosynthetic process (GO:0019240)3.07159886
59immunoglobulin mediated immune response (GO:0016064)3.06931203
60detection of biotic stimulus (GO:0009595)3.05663888
61retrograde transport, vesicle recycling within Golgi (GO:0000301)3.05452232
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.04371197
63neutrophil activation (GO:0042119)3.04032557
64neutrophil mediated immunity (GO:0002446)3.03346524
65positive regulation of mast cell activation (GO:0033005)3.03089008
66microglial cell activation (GO:0001774)3.02891974
67regulation of hypersensitivity (GO:0002883)3.02240147
68positive regulation of cellular amide metabolic process (GO:0034250)3.00704699
69regulation of ARF protein signal transduction (GO:0032012)2.99982094
70negative regulation of cell size (GO:0045792)2.98429795
71establishment of protein localization to Golgi (GO:0072600)2.98146593
72protein targeting to Golgi (GO:0000042)2.97757108
73regulation of beta-amyloid formation (GO:1902003)2.96781348
74macrophage activation (GO:0042116)2.96590758
75regulation of interferon-beta biosynthetic process (GO:0045357)2.94792540
76negative regulation of erythrocyte differentiation (GO:0045647)2.92974826
77positive regulation of Rap GTPase activity (GO:0032854)2.92597370
78positive regulation of mast cell activation involved in immune response (GO:0033008)2.88893151
79positive regulation of mast cell degranulation (GO:0043306)2.88893151
80histone H3-K9 demethylation (GO:0033169)2.87282755
81regulation of DNA methylation (GO:0044030)2.87200558
82negative regulation of cAMP-mediated signaling (GO:0043951)2.87065717
83COPI coating of Golgi vesicle (GO:0048205)2.85177805
84Golgi transport vesicle coating (GO:0048200)2.85177805
85response to interleukin-15 (GO:0070672)2.84541718
86protein demethylation (GO:0006482)2.83859380
87protein dealkylation (GO:0008214)2.83859380
88regulation of p38MAPK cascade (GO:1900744)2.82488582
89positive regulation of protein deacetylation (GO:0090312)2.82028116
90negative regulation of cardiac muscle tissue growth (GO:0055022)2.80713676
91negative regulation of heart growth (GO:0061117)2.80713676
92granulocyte activation (GO:0036230)2.79452562
93germinal center formation (GO:0002467)2.79310992
94pre-miRNA processing (GO:0031054)2.76710382
95negative regulation of histone methylation (GO:0031061)2.74859860
96nerve growth factor signaling pathway (GO:0038180)2.74016592
97regulation of regulated secretory pathway (GO:1903305)2.73494056
98negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.72784373
99germ cell migration (GO:0008354)2.71218838
100negative regulation of leukocyte mediated immunity (GO:0002704)2.70963377
101regulation of cellular amide metabolic process (GO:0034248)2.70417129
102regulation of mast cell activation (GO:0033003)2.70027177
103histone H3-K36 demethylation (GO:0070544)2.69778564
104growth hormone receptor signaling pathway (GO:0060396)2.69543805
105regulation of amyloid precursor protein catabolic process (GO:1902991)2.67850319
106activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.67685529
107insulin-like growth factor receptor signaling pathway (GO:0048009)2.67327346
108apoptotic cell clearance (GO:0043277)2.67224745
109negative regulation of T cell mediated immunity (GO:0002710)2.66896529
110activated T cell proliferation (GO:0050798)2.66619951
111regulation of histone deacetylation (GO:0031063)2.63796390
112cortical cytoskeleton organization (GO:0030865)2.63599882
113production of molecular mediator involved in inflammatory response (GO:0002532)2.63564938
114positive regulation of p38MAPK cascade (GO:1900745)2.63029612
115thymic T cell selection (GO:0045061)2.62123989
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.59598503
117antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.59512983
118positive regulation of nuclease activity (GO:0032075)2.57830457
119respiratory burst (GO:0045730)2.56333704
120myeloid cell activation involved in immune response (GO:0002275)2.54083213
121establishment of nucleus localization (GO:0040023)2.53834806
122glucocorticoid receptor signaling pathway (GO:0042921)2.53705481
123macroautophagy (GO:0016236)2.53490661
124B cell receptor signaling pathway (GO:0050853)2.53448021
125positive regulation of leukocyte degranulation (GO:0043302)2.52649953
126phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.52357369
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52219535
128myeloid leukocyte mediated immunity (GO:0002444)2.52045078
129interkinetic nuclear migration (GO:0022027)2.51136951
130positive regulation of B cell differentiation (GO:0045579)2.51112707
131positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49966470
132positive T cell selection (GO:0043368)2.49466973
133stress fiber assembly (GO:0043149)2.49209722
134regulation of NFAT protein import into nucleus (GO:0051532)2.48326749
135sodium ion export (GO:0071436)2.47758815
136regulation of T-helper 2 cell differentiation (GO:0045628)2.47264746
137cellular response to interleukin-15 (GO:0071350)2.47014675
138mannose metabolic process (GO:0006013)2.46179133
139NLS-bearing protein import into nucleus (GO:0006607)2.45246636
140erythrocyte maturation (GO:0043249)2.45171556
141positive regulation of erythrocyte differentiation (GO:0045648)2.45106558
142positive regulation of regulated secretory pathway (GO:1903307)2.44714691
143histone H4-K16 acetylation (GO:0043984)2.44563165
144mitotic G1 DNA damage checkpoint (GO:0031571)2.43847913
145regulation of erythrocyte differentiation (GO:0045646)2.42301520
146tolerance induction (GO:0002507)2.42265510
147adherens junction assembly (GO:0034333)2.42262583
148regulation of Rap GTPase activity (GO:0032317)2.42228254
149positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.41142437
150plasma membrane repair (GO:0001778)2.41020776
151negative regulation of nucleotide catabolic process (GO:0030812)2.40246173
152negative regulation of T-helper cell differentiation (GO:0045623)2.39646568
153negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.39646568
154negative regulation of toll-like receptor signaling pathway (GO:0034122)2.39627828
155cell-substrate adherens junction assembly (GO:0007045)2.35486862
156focal adhesion assembly (GO:0048041)2.35486862
157peptidyl-threonine modification (GO:0018210)2.34529926
158cell-substrate junction assembly (GO:0007044)2.32924856
159peptidyl-threonine phosphorylation (GO:0018107)2.32063992
160regulation of fatty acid beta-oxidation (GO:0031998)2.31704588
161activation of JUN kinase activity (GO:0007257)2.31398443
162positive regulation of lamellipodium assembly (GO:0010592)2.29418516
163regulation of nuclease activity (GO:0032069)2.29361531
164mitotic G1/S transition checkpoint (GO:0044819)2.29235901
165cellular response to growth hormone stimulus (GO:0071378)2.28552470
166adaptation of signaling pathway (GO:0023058)2.27988705
167RNA stabilization (GO:0043489)2.26906695
168mRNA stabilization (GO:0048255)2.26906695
169regulation of B cell receptor signaling pathway (GO:0050855)2.26709588
170response to nerve growth factor (GO:1990089)2.26700870
171cellular response to nerve growth factor stimulus (GO:1990090)2.26700870
172T cell selection (GO:0045058)2.26034629
173activation of protein kinase A activity (GO:0034199)2.25990039
174regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.24306808
175platelet formation (GO:0030220)2.22988043
176epithelial cell differentiation involved in prostate gland development (GO:0060742)2.22315252
177glial cell proliferation (GO:0014009)2.22089403
178positive regulation of myotube differentiation (GO:0010831)2.21565611
179positive regulation of glycogen biosynthetic process (GO:0045725)2.20728588
180corticosteroid receptor signaling pathway (GO:0031958)2.19901721
181protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.19351814
182endoplasmic reticulum unfolded protein response (GO:0030968)2.19187499
183histone lysine demethylation (GO:0070076)2.19094696
184lamellipodium organization (GO:0097581)2.18564619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50748505
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.97532037
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.36707989
4MYC_22102868_ChIP-Seq_BL_Human3.24385715
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06889585
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.03333456
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01453341
8TCF7_22412390_ChIP-Seq_EML_Mouse2.84774517
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.73438339
10KDM2B_26808549_Chip-Seq_DND41_Human2.71684194
11VDR_21846776_ChIP-Seq_THP-1_Human2.67503125
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.56091827
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.55383616
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.42377024
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39433292
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.38876949
17GATA1_22025678_ChIP-Seq_K562_Human2.19751044
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.15174481
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.12125951
20ZNF263_19887448_ChIP-Seq_K562_Human2.06449919
21TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.05486881
22UTX_26944678_Chip-Seq_JUKART_Human2.02412442
23MAF_26560356_Chip-Seq_TH1_Human2.00918669
24KDM2B_26808549_Chip-Seq_JURKAT_Human1.96637820
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93526409
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91090625
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90663081
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.89892369
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89889919
30SCL_19346495_ChIP-Seq_HPC-7_Human1.85048421
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84181626
32GATA1_19941826_ChIP-Seq_K562_Human1.83277913
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.83100468
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.82760702
35KDM2B_26808549_Chip-Seq_K562_Human1.82328672
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81538108
37VDR_24787735_ChIP-Seq_THP-1_Human1.81169940
38SPI1_23127762_ChIP-Seq_K562_Human1.81036111
39CLOCK_20551151_ChIP-Seq_293T_Human1.76985544
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74301631
41RUNX_20019798_ChIP-Seq_JUKART_Human1.73240004
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70063037
43VDR_24763502_ChIP-Seq_THP-1_Human1.69279902
44* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68216896
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64682624
46LXR_22292898_ChIP-Seq_THP-1_Human1.63036177
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60313768
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58526696
49FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.57371378
50* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56911438
51MYB_26560356_Chip-Seq_TH2_Human1.53420677
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.51670099
53* GATA1_19941827_ChIP-Seq_MEL_Mouse1.50758142
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50453153
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47061244
56NCOR1_26117541_ChIP-Seq_K562_Human1.45541726
57ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.43489977
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.41591663
59MYB_26560356_Chip-Seq_TH1_Human1.40907597
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40826482
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40058135
62RACK7_27058665_Chip-Seq_MCF-7_Human1.37573214
63* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37345882
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37258426
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37150035
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36052397
67* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35218144
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35174384
69* IRF8_27001747_Chip-Seq_BMDM_Mouse1.34770097
70GATA2_19941826_ChIP-Seq_K562_Human1.31819013
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31436329
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.30216447
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29304973
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27207902
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.26917638
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.26811744
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.26484470
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.26484470
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.24803007
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.24647340
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23900119
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21160653
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20874821
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20457624
85CREB1_26743006_Chip-Seq_LNCaP_Human1.17521301
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16630421
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15990118
88* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.15202677
89MAF_26560356_Chip-Seq_TH2_Human1.14685301
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14048674
91* GATA3_27048872_Chip-Seq_THYMUS_Human1.13675425
92SPI1_23547873_ChIP-Seq_NB4_Human1.13143389
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12740466
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11808743
95ATF3_27146783_Chip-Seq_COLON_Human1.09208391
96DROSHA_22980978_ChIP-Seq_HELA_Human1.07863899
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07807982
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07666349
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05419742
100* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05403884
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05032552
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04840002
103E2F7_22180533_ChIP-Seq_HELA_Human1.03835824
104FOXA2_19822575_ChIP-Seq_HepG2_Human1.03834280
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03528087
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01857992
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01252423
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00752601
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00546527
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00184868
111KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99848336
112RARB_27405468_Chip-Seq_BRAIN_Mouse0.99022661
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98188860
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96268689
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95932389
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94952570
117CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94818312
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92970089
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92642428
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92166514
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90959194
122* PU_27001747_Chip-Seq_BMDM_Mouse0.89291764
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89064801
124AHR_22903824_ChIP-Seq_MCF-7_Human0.87960872
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87897369
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86796427
127GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86643022
128* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86423838
129GF1_26923725_Chip-Seq_HPCs_Mouse0.83412921
130* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80617315
131TP53_16413492_ChIP-PET_HCT116_Human0.80127359
132SMRT_27268052_Chip-Seq_Bcells_Human0.79299403
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.79023095
134* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76985592
135OCT4_19829295_ChIP-Seq_ESCs_Human0.76575898
136SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74783717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.13602247
2MP0003300_gastrointestinal_ulcer4.12623032
3MP0003705_abnormal_hypodermis_morpholog3.90874688
4MP0003303_peritoneal_inflammation3.83489967
5MP0000569_abnormal_digit_pigmentation3.50777921
6MP0002877_abnormal_melanocyte_morpholog3.21750119
7MP0002419_abnormal_innate_immunity2.65969781
8MP0008260_abnormal_autophagy2.58455364
9MP0005076_abnormal_cell_differentiation2.57726389
10MP0010234_abnormal_vibrissa_follicle2.49020703
11MP0005451_abnormal_body_composition2.46259768
12MP0010352_gastrointestinal_tract_polyps2.30274228
13MP0008961_abnormal_basal_metabolism2.29462553
14MP0005025_abnormal_response_to2.27590809
15MP0004510_myositis2.25330748
16MP0002166_altered_tumor_susceptibility2.05830743
17MP0009278_abnormal_bone_marrow2.04032194
18MP0003045_fibrosis1.97595181
19MP0009785_altered_susceptibility_to1.96179824
20MP0004130_abnormal_muscle_cell1.95793514
21MP0009780_abnormal_chondrocyte_physiolo1.87108717
22MP0004808_abnormal_hematopoietic_stem1.86060546
23MP0004185_abnormal_adipocyte_glucose1.84039465
24MP0003566_abnormal_cell_adhesion1.78507957
25MP0005409_darkened_coat_color1.75330644
26MP0003690_abnormal_glial_cell1.74412066
27MP0001533_abnormal_skeleton_physiology1.70644908
28MP0004381_abnormal_hair_follicle1.67696861
29MP0003172_abnormal_lysosome_physiology1.67395857
30MP0005058_abnormal_lysosome_morphology1.64047553
31MP0002909_abnormal_adrenal_gland1.62752478
32MP0003656_abnormal_erythrocyte_physiolo1.58125473
33MP0005375_adipose_tissue_phenotype1.57974575
34MP0005666_abnormal_adipose_tissue1.57391274
35MP0006082_CNS_inflammation1.56972951
36MP0000685_abnormal_immune_system1.55177347
37MP0010307_abnormal_tumor_latency1.51731451
38MP0000733_abnormal_muscle_development1.51096631
39MP0003329_amyloid_beta_deposits1.50060166
40MP0000003_abnormal_adipose_tissue1.50058733
41MP0004947_skin_inflammation1.45061207
42MP0002998_abnormal_bone_remodeling1.44034846
43MP0002837_dystrophic_cardiac_calcinosis1.43981838
44MP0002132_abnormal_respiratory_system1.42676780
45MP0000371_diluted_coat_color1.38501741
46MP0003866_abnormal_defecation1.37542482
47MP0003191_abnormal_cellular_cholesterol1.36831829
48MP0005464_abnormal_platelet_physiology1.35990275
49MP0004087_abnormal_muscle_fiber1.28460608
50MP0004084_abnormal_cardiac_muscle1.26871726
51MP0001851_eye_inflammation1.26331285
52MP0003091_abnormal_cell_migration1.26154164
53MP0002138_abnormal_hepatobiliary_system1.26115091
54MP0005397_hematopoietic_system_phenotyp1.24886748
55MP0001545_abnormal_hematopoietic_system1.24886748
56MP0002398_abnormal_bone_marrow1.23162757
57MP0010630_abnormal_cardiac_muscle1.22419092
58MP0002148_abnormal_hypersensitivity_rea1.21952944
59MP0005310_abnormal_salivary_gland1.21922407
60MP0002396_abnormal_hematopoietic_system1.17797756
61MP0002332_abnormal_exercise_endurance1.17684135
62MP0000465_gastrointestinal_hemorrhage1.16591009
63MP0001800_abnormal_humoral_immune1.14670931
64MP0001845_abnormal_inflammatory_respons1.12075273
65MP0000751_myopathy1.11443120
66MP0001849_ear_inflammation1.11299119
67MP0002006_tumorigenesis1.10562500
68MP0003436_decreased_susceptibility_to1.10154321
69MP0000703_abnormal_thymus_morphology1.08097232
70MP0003879_abnormal_hair_cell1.06637149
71MP0009840_abnormal_foam_cell1.06490810
72MP0001790_abnormal_immune_system1.05582333
73MP0005387_immune_system_phenotype1.05582333
74MP0004883_abnormal_blood_vessel1.05371516
75MP0006054_spinal_hemorrhage1.05351254
76MP0002277_abnormal_respiratory_mucosa1.05231870
77MP0008877_abnormal_DNA_methylation1.04960891
78MP0000015_abnormal_ear_pigmentation1.03434246
79MP0005164_abnormal_response_to1.00617464
80MP0003453_abnormal_keratinocyte_physiol0.99119303
81MP0003183_abnormal_peptide_metabolism0.98915425
82MP0002420_abnormal_adaptive_immunity0.96765360
83MP0002722_abnormal_immune_system0.96196146
84MP0000747_muscle_weakness0.96148069
85MP0004036_abnormal_muscle_relaxation0.95690156
86MP0002928_abnormal_bile_duct0.95523683
87MP0001873_stomach_inflammation0.94067884
88MP0001819_abnormal_immune_cell0.93961004
89MP0002452_abnormal_antigen_presenting0.93583775
90MP0004197_abnormal_fetal_growth/weight/0.93457487
91MP0003075_altered_response_to0.92205157
92MP0000689_abnormal_spleen_morphology0.90244832
93MP0003718_maternal_effect0.89640046
94* MP0008469_abnormal_protein_level0.89559000
95MP0003763_abnormal_thymus_physiology0.89516720
96MP0003699_abnormal_female_reproductive0.89332790
97MP0000716_abnormal_immune_system0.88977131
98MP0004859_abnormal_synaptic_plasticity0.88778829
99MP0002269_muscular_atrophy0.88602284
100MP0008004_abnormal_stomach_pH0.88509413
101MP0005023_abnormal_wound_healing0.88454166
102MP0001835_abnormal_antigen_presentation0.86900958
103MP0009115_abnormal_fat_cell0.86288675
104MP0009764_decreased_sensitivity_to0.85383792
105MP0002971_abnormal_brown_adipose0.85033187
106MP0000858_altered_metastatic_potential0.83646796
107MP0000537_abnormal_urethra_morphology0.83503545
108MP0005166_decreased_susceptibility_to0.83362312
109MP0004484_altered_response_of0.83178927
110MP0000013_abnormal_adipose_tissue0.81401374
111MP0010155_abnormal_intestine_physiology0.81183922
112MP0000604_amyloidosis0.80998099
113MP0008770_decreased_survivor_rate0.79594491
114MP0003567_abnormal_fetal_cardiomyocyte0.79393407
115MP0002429_abnormal_blood_cell0.78213636
116MP0002723_abnormal_immune_serum0.78097603
117MP0002970_abnormal_white_adipose0.78088572
118MP0001915_intracranial_hemorrhage0.77226603
119MP0003221_abnormal_cardiomyocyte_apopto0.76766610
120MP0002925_abnormal_cardiovascular_devel0.76385712
121MP0005671_abnormal_response_to0.74893748
122MP0003646_muscle_fatigue0.74681812
123MP0003787_abnormal_imprinting0.74366124
124MP0002405_respiratory_system_inflammati0.73651920
125MP0005621_abnormal_cell_physiology0.73512151
126MP0000759_abnormal_skeletal_muscle0.72982748
127MP0002106_abnormal_muscle_physiology0.71598981
128MP0004858_abnormal_nervous_system0.71428876
129MP0003828_pulmonary_edema0.71356421
130MP0000266_abnormal_heart_morphology0.70930722
131MP0002234_abnormal_pharynx_morphology0.70782149
132MP0008775_abnormal_heart_ventricle0.70237092
133MP0005000_abnormal_immune_tolerance0.68304827
134MP0002086_abnormal_extraembryonic_tissu0.68022436
135MP0001784_abnormal_fluid_regulation0.68017929
136MP0004264_abnormal_extraembryonic_tissu0.67634315
137MP0002009_preneoplasia0.67265764
138MP0005167_abnormal_blood-brain_barrier0.66497944
139MP0000609_abnormal_liver_physiology0.66293525
140MP0002128_abnormal_blood_circulation0.66019921
141MP0001958_emphysema0.65680245
142MP0004233_abnormal_muscle_weight0.65150011
143MP0008874_decreased_physiological_sensi0.64131759
144MP0005390_skeleton_phenotype0.63251512

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.46840045
2Recurrent abscess formation (HP:0002722)4.29289776
3Myositis (HP:0100614)4.20538718
4Abnormality of macrophages (HP:0004311)4.05490695
5Orchitis (HP:0100796)3.95900410
6Optic neuritis (HP:0100653)3.83582596
7Retrobulbar optic neuritis (HP:0100654)3.83582596
8Recurrent gram-negative bacterial infections (HP:0005420)3.58686891
9Cerebral aneurysm (HP:0004944)3.43041915
10Gingivitis (HP:0000230)3.25548093
11Papillary thyroid carcinoma (HP:0002895)3.21949433
12Stomatitis (HP:0010280)3.21401321
13Gastrointestinal infarctions (HP:0005244)3.20323777
14Hypochromic microcytic anemia (HP:0004840)3.16577318
15Macroorchidism (HP:0000053)3.12766116
16Hyperacusis (HP:0010780)3.09630082
17Colitis (HP:0002583)2.95457707
18Abnormality of the fingertips (HP:0001211)2.92422515
19Keratoconjunctivitis sicca (HP:0001097)2.91611556
20Recurrent skin infections (HP:0001581)2.73049319
21Keratoconjunctivitis (HP:0001096)2.62881408
22Mediastinal lymphadenopathy (HP:0100721)2.59324915
23Obstructive sleep apnea (HP:0002870)2.58801529
24Difficulty running (HP:0009046)2.55443166
25Insomnia (HP:0100785)2.51408522
26Chronic mucocutaneous candidiasis (HP:0002728)2.49723943
27Recurrent cutaneous fungal infections (HP:0011370)2.49723943
28Muscle fiber splitting (HP:0003555)2.46900310
29Increased IgE level (HP:0003212)2.46835517
30Subacute progressive viral hepatitis (HP:0006572)2.45782176
31Hematochezia (HP:0002573)2.43200942
32Increased density of long bones (HP:0006392)2.40523739
33Papilledema (HP:0001085)2.40073076
34Loss of speech (HP:0002371)2.36392049
35Inflammation of the large intestine (HP:0002037)2.35156053
36Enlarged penis (HP:0000040)2.32864306
37Gastrointestinal inflammation (HP:0004386)2.32641134
38Hand muscle atrophy (HP:0009130)2.32030274
39Mitral valve prolapse (HP:0001634)2.30847955
40Prolonged bleeding time (HP:0003010)2.30483051
41Amyloidosis (HP:0011034)2.30265318
42Dysmetric saccades (HP:0000641)2.30238918
43Hemoptysis (HP:0002105)2.30155179
44Elevated erythrocyte sedimentation rate (HP:0003565)2.27492434
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.25125276
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25121626
47Distal upper limb amyotrophy (HP:0007149)2.23106547
48Upper limb amyotrophy (HP:0009129)2.23106547
49Osteomalacia (HP:0002749)2.22017162
50Malnutrition (HP:0004395)2.21283945
51Long toe (HP:0010511)2.21278380
52Postural instability (HP:0002172)2.19669698
53Meningitis (HP:0001287)2.19128286
54Peritonitis (HP:0002586)2.17191129
55Elfin facies (HP:0004428)2.17125306
56Viral hepatitis (HP:0006562)2.16503875
57Aortic aneurysm (HP:0004942)2.15826498
58Hypochromic anemia (HP:0001931)2.15625754
59Episodic fever (HP:0001954)2.14457661
60Aneurysm (HP:0002617)2.12849388
61Hyporeflexia of lower limbs (HP:0002600)2.12302100
62Truncal obesity (HP:0001956)2.11497477
63Vasculitis (HP:0002633)2.10885984
64Frequent falls (HP:0002359)2.10475770
65Papilloma (HP:0012740)2.10307365
66Verrucae (HP:0200043)2.10307365
67Pustule (HP:0200039)2.10114109
68Osteomyelitis (HP:0002754)2.09206184
69Gingival bleeding (HP:0000225)2.08698177
70Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08168687
71Slow saccadic eye movements (HP:0000514)2.08067350
72Recurrent viral infections (HP:0004429)2.07256363
73Urticaria (HP:0001025)2.04657449
74Narrow palate (HP:0000189)2.04516565
75Supranuclear gaze palsy (HP:0000605)2.04155365
76Microcytic anemia (HP:0001935)2.03661397
77Periodontitis (HP:0000704)2.01481997
78Arterial thrombosis (HP:0004420)2.00665592
79Chronic obstructive pulmonary disease (HP:0006510)2.00049396
80Obstructive lung disease (HP:0006536)2.00049396
81Encephalitis (HP:0002383)2.00016293
82Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99936023
83Heterotopia (HP:0002282)1.99077822
84Lymphangioma (HP:0100764)1.98733340
85Increased connective tissue (HP:0009025)1.97530748
86Abnormality of the thoracic spine (HP:0100711)1.97130709
87Shallow orbits (HP:0000586)1.96313404
88Renovascular hypertension (HP:0100817)1.95439447
89Lip pit (HP:0100267)1.95396687
90Anterior segment dysgenesis (HP:0007700)1.95156222
91Abnormality of the endocardium (HP:0004306)1.94951267
92Cellulitis (HP:0100658)1.94277105
93Resting tremor (HP:0002322)1.93964147
94Poikilocytosis (HP:0004447)1.93405467
95Neurofibrillary tangles (HP:0002185)1.91638735
96Facial diplegia (HP:0001349)1.91616097
97Pointed chin (HP:0000307)1.90602562
98Vertebral arch anomaly (HP:0008438)1.90133397
99Nasal polyposis (HP:0100582)1.89694165
100Pulmonary infiltrates (HP:0002113)1.89239607
101Disproportionate tall stature (HP:0001519)1.89225478
102Toxemia of pregnancy (HP:0100603)1.88111176
103T lymphocytopenia (HP:0005403)1.87332140
104Eczematoid dermatitis (HP:0000976)1.87067795
105Thoracic kyphosis (HP:0002942)1.86664234
106Broad metatarsal (HP:0001783)1.85153584
107Abnormality of the nasal mucosa (HP:0000433)1.82981157
108Chest pain (HP:0100749)1.81947906
109Asymmetric septal hypertrophy (HP:0001670)1.81336996
110Rectal prolapse (HP:0002035)1.80867232
111Interstitial pulmonary disease (HP:0006530)1.80433583
112Neuronal loss in central nervous system (HP:0002529)1.80245356
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79850312
114Bicuspid aortic valve (HP:0001647)1.78316396
115Global brain atrophy (HP:0002283)1.77861701
116Striae distensae (HP:0001065)1.77154325
117Leukocytosis (HP:0001974)1.76926223
118Abnormality of the lower motor neuron (HP:0002366)1.75432511
119Genu recurvatum (HP:0002816)1.75267414
120Abnormality of liposaccharide metabolism (HP:0010968)1.75200667
121Abnormality of glycosphingolipid metabolism (HP:0004343)1.75200667
122Abnormality of glycolipid metabolism (HP:0010969)1.75200667
123Recurrent fungal infections (HP:0002841)1.75167481
124Lower limb hyperreflexia (HP:0002395)1.74033507
125Scapular winging (HP:0003691)1.73925979
126High pitched voice (HP:0001620)1.73803012
127Ulnar bowing (HP:0003031)1.73287553
128Ocular albinism (HP:0001107)1.73275042
129Acne (HP:0001061)1.71492770
130Subaortic stenosis (HP:0001682)1.70663870
131Abnormality of the left ventricular outflow tract (HP:0011103)1.70663870
132Epistaxis (HP:0000421)1.69535718
133Dilatation of the ascending aorta (HP:0005111)1.69522988
134Basal cell carcinoma (HP:0002671)1.68531509
135Recurrent bronchitis (HP:0002837)1.68531274
136Bowel diverticulosis (HP:0005222)1.68498154
137Pulmonary embolism (HP:0002204)1.67308093
138Obsessive-compulsive behavior (HP:0000722)1.66765309
139Hamartoma of the eye (HP:0010568)1.66202614
140Onion bulb formation (HP:0003383)1.65409567
141Exercise-induced muscle cramps (HP:0003710)1.65391210
142Reticulocytosis (HP:0001923)1.64279602
143Neoplasm of the heart (HP:0100544)1.64122976
144Abnormality of oral frenula (HP:0000190)1.63920201
145Absent frontal sinuses (HP:0002688)1.62926681
146Cheilitis (HP:0100825)1.62496752
147Short 4th metacarpal (HP:0010044)1.62277732
148Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.62277732
149Increased variability in muscle fiber diameter (HP:0003557)1.61587150
150Thin bony cortex (HP:0002753)1.61411839
151Polycythemia (HP:0001901)1.61268086
152Abnormality of T cell number (HP:0011839)1.60699975
153Thyroid carcinoma (HP:0002890)1.60533944
154Diminished motivation (HP:0000745)1.60368326
155Emphysema (HP:0002097)1.60144476
156Exercise-induced myalgia (HP:0003738)1.60131122
157Increased cerebral lipofuscin (HP:0011813)1.60097642
158Cerebral inclusion bodies (HP:0100314)1.59704657
159Ankle contracture (HP:0006466)1.58198839
160Apathy (HP:0000741)1.58007339
161EMG: neuropathic changes (HP:0003445)1.57089994
162Spontaneous hematomas (HP:0007420)1.56766097
163Radial bowing (HP:0002986)1.56468028
164Chronic otitis media (HP:0000389)1.56339215
165Ventricular fibrillation (HP:0001663)1.56316211
166Ependymoma (HP:0002888)1.56253476
167Hypercortisolism (HP:0001578)1.55690627
168Panhypogammaglobulinemia (HP:0003139)1.55667730
169Glomerulopathy (HP:0100820)1.55168772
170Prominent nose (HP:0000448)1.54830218
171Abnormality of the peritoneum (HP:0002585)1.54810971
172Abnormality of the astrocytes (HP:0100707)1.54719582
173Astrocytoma (HP:0009592)1.54719582
174Decreased motor nerve conduction velocity (HP:0003431)1.53319750
175Fibrous tissue neoplasm (HP:0012316)1.52789079
176Proximal amyotrophy (HP:0007126)1.52271435
177Overriding aorta (HP:0002623)1.52260691
178Dysostosis multiplex (HP:0000943)1.51873475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.60283421
2TRIB34.23364365
3PKN23.75095001
4MAP3K103.06234197
5RIPK12.68714843
6PRPF4B2.68199416
7TTN2.33606502
8CDK122.31734399
9MAP3K132.15222471
10IRAK42.05929075
11BLK1.97139798
12MAP2K31.82075456
13PTK61.80764209
14CAMK1D1.74258755
15MAP4K11.73186570
16CAMK1G1.69375315
17TNK21.63316263
18SCYL21.59049586
19NTRK31.55225672
20PDGFRA1.50403360
21MAP3K31.47138662
22ERN11.44904370
23RET1.44568123
24LRRK21.43988181
25ALK1.38108093
26GRK61.36366576
27FGR1.31712947
28JAK11.25537709
29IKBKE1.23125979
30SIK21.23109903
31KSR21.21716224
32RPS6KB21.20262192
33KSR11.20022290
34YES11.17606266
35MAP3K141.17410187
36PRKCH1.15641918
37SGK21.14622738
38FGFR31.14513791
39DMPK1.14257347
40TYK21.11958908
41STK101.05688415
42BMX1.04043300
43EPHB11.03368538
44MAPKAPK31.03273116
45FGFR41.03083717
46SIK11.02646567
47MAP3K71.00203277
48MAP3K90.99385281
49IRAK10.97503891
50CDK60.97403879
51EPHA30.96329664
52STK380.96103262
53JAK30.95721311
54TGFBR20.95314450
55FES0.94609990
56PRKD30.94572585
57JAK20.93464939
58MTOR0.93450228
59ZAP700.93001040
60PDGFRB0.92915613
61IRAK20.91685578
62NTRK20.91112951
63ICK0.90877986
64CAMKK10.90315128
65PRKD20.86943656
66MAP3K20.86719498
67RAF10.85526769
68SGK30.84759137
69NEK60.83660695
70TAOK10.82883524
71HIPK20.81401523
72HCK0.80830343
73MAP3K60.80709789
74FLT30.79446085
75CDK90.77341348
76PIK3CG0.76821842
77ITK0.76189738
78STK240.75807464
79LMTK20.75351618
80TYRO30.74814606
81TAOK30.74576397
82PAK60.74488293
83CDK40.72454058
84SGK2230.71989388
85SGK4940.71989388
86NEK20.71871812
87LYN0.71028533
88LCK0.70934346
89RPS6KA20.70653879
90CSF1R0.69152569
91PDK10.68569475
92FGFR20.68377977
93TRPM70.67738323
94STK110.67271892
95NLK0.66337708
96MAPK70.65912561
97TBK10.65325701
98MAP2K40.64948589
99MAPK110.64937297
100BTK0.64610704
101DAPK20.63998557
102MAP3K50.63431191
103CDC42BPA0.63033574
104MAP3K40.62710685
105MAP3K110.62374604
106LATS10.62083738
107CSK0.61332757
108CAMK40.61015491
109PTK2B0.60682757
110PAK20.59960457
111MARK20.59589294
112SIK30.59540232
113DYRK1B0.58371712
114ILK0.57210023
115SYK0.55563124
116TXK0.54753845
117MAP3K10.54694517
118PAK40.54584313
119RIPK40.54130672
120KIT0.53446309
121MOS0.52321125
122TAOK20.52228781
123SGK10.51862329
124MARK30.50583113
125PRKAA10.50557694
126EGFR0.48764361
127PRKCZ0.48568912
128FGFR10.48079526
129PRKD10.46839325
130BRD40.46095850
131MAPK120.45518847
132PRKAA20.45482344
133STK40.44827326
134PDPK10.43575610
135PTK20.43053215
136PIM10.40498205
137MELK0.38305346
138RPS6KA40.38287837
139NTRK10.37747043
140WNK10.37594942

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.86492007
2B cell receptor signaling pathway_Homo sapiens_hsa046621.83147905
3mTOR signaling pathway_Homo sapiens_hsa041501.79735935
4Dorso-ventral axis formation_Homo sapiens_hsa043201.79345047
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62153885
6Non-small cell lung cancer_Homo sapiens_hsa052231.59343001
7Type II diabetes mellitus_Homo sapiens_hsa049301.54039794
8Insulin resistance_Homo sapiens_hsa049311.51301981
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49444687
10Osteoclast differentiation_Homo sapiens_hsa043801.49017367
11Neurotrophin signaling pathway_Homo sapiens_hsa047221.46475890
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42239564
13Glioma_Homo sapiens_hsa052141.40839663
14Acute myeloid leukemia_Homo sapiens_hsa052211.39169922
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38674236
16Lysine degradation_Homo sapiens_hsa003101.36408343
17VEGF signaling pathway_Homo sapiens_hsa043701.35195679
18Pancreatic cancer_Homo sapiens_hsa052121.34647777
19Staphylococcus aureus infection_Homo sapiens_hsa051501.32432253
20Malaria_Homo sapiens_hsa051441.31890224
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31787730
22Platelet activation_Homo sapiens_hsa046111.27629987
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.24005218
24Endometrial cancer_Homo sapiens_hsa052131.23995953
25Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20727753
26Insulin signaling pathway_Homo sapiens_hsa049101.20511460
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20339008
28* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18230781
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17668117
30Prolactin signaling pathway_Homo sapiens_hsa049171.17534531
31Toxoplasmosis_Homo sapiens_hsa051451.14745145
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14582053
33Leishmaniasis_Homo sapiens_hsa051401.14185077
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.12688404
35Estrogen signaling pathway_Homo sapiens_hsa049151.11794135
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09194959
37T cell receptor signaling pathway_Homo sapiens_hsa046601.08141349
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06278501
39Focal adhesion_Homo sapiens_hsa045101.05509996
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05509205
41Renal cell carcinoma_Homo sapiens_hsa052111.05212435
42Glucagon signaling pathway_Homo sapiens_hsa049221.05044605
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.04923146
44Proteoglycans in cancer_Homo sapiens_hsa052051.04640243
45Small cell lung cancer_Homo sapiens_hsa052221.01146208
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99063741
47Chemokine signaling pathway_Homo sapiens_hsa040620.97464651
48GnRH signaling pathway_Homo sapiens_hsa049120.97084901
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.95684181
50FoxO signaling pathway_Homo sapiens_hsa040680.95269097
51Ovarian steroidogenesis_Homo sapiens_hsa049130.95103562
52AMPK signaling pathway_Homo sapiens_hsa041520.94867929
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94759824
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.94023269
55Nitrogen metabolism_Homo sapiens_hsa009100.93685557
56Long-term potentiation_Homo sapiens_hsa047200.93428028
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93183559
58Phagosome_Homo sapiens_hsa041450.92870067
59Amoebiasis_Homo sapiens_hsa051460.92801753
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90817069
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90123248
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89442369
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89384452
64Colorectal cancer_Homo sapiens_hsa052100.89126235
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88028152
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87161871
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.86977513
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86792362
69Endocytosis_Homo sapiens_hsa041440.86617932
70Legionellosis_Homo sapiens_hsa051340.85689361
71ABC transporters_Homo sapiens_hsa020100.84789818
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84693681
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84614304
74Dilated cardiomyopathy_Homo sapiens_hsa054140.84135616
75Viral myocarditis_Homo sapiens_hsa054160.82955303
76Gastric acid secretion_Homo sapiens_hsa049710.82309057
77Primary immunodeficiency_Homo sapiens_hsa053400.80850597
78MicroRNAs in cancer_Homo sapiens_hsa052060.78720265
79Renin secretion_Homo sapiens_hsa049240.78492438
80* Inositol phosphate metabolism_Homo sapiens_hsa005620.78146365
81Adherens junction_Homo sapiens_hsa045200.77914386
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77758250
83Tuberculosis_Homo sapiens_hsa051520.77464797
84Oxytocin signaling pathway_Homo sapiens_hsa049210.76397548
85Antigen processing and presentation_Homo sapiens_hsa046120.76367214
86MAPK signaling pathway_Homo sapiens_hsa040100.76095763
87Hematopoietic cell lineage_Homo sapiens_hsa046400.75832720
88Herpes simplex infection_Homo sapiens_hsa051680.75683734
89HIF-1 signaling pathway_Homo sapiens_hsa040660.75430325
90Hepatitis B_Homo sapiens_hsa051610.74453601
91Circadian rhythm_Homo sapiens_hsa047100.73833264
92Prostate cancer_Homo sapiens_hsa052150.73731912
93Other glycan degradation_Homo sapiens_hsa005110.73585112
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72969047
95African trypanosomiasis_Homo sapiens_hsa051430.72381812
96Viral carcinogenesis_Homo sapiens_hsa052030.72349138
97Choline metabolism in cancer_Homo sapiens_hsa052310.71923119
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67503749
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.66899894
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66318899
101Measles_Homo sapiens_hsa051620.65396291
102Rap1 signaling pathway_Homo sapiens_hsa040150.65037638
103Long-term depression_Homo sapiens_hsa047300.64634608
104ErbB signaling pathway_Homo sapiens_hsa040120.64344630
105TNF signaling pathway_Homo sapiens_hsa046680.63961451
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.63285033
107Pertussis_Homo sapiens_hsa051330.63222330
108Apoptosis_Homo sapiens_hsa042100.63177762
109Insulin secretion_Homo sapiens_hsa049110.61613445
110Thyroid cancer_Homo sapiens_hsa052160.61327888
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59890424
112Shigellosis_Homo sapiens_hsa051310.59392239
113Influenza A_Homo sapiens_hsa051640.59148438
114Cholinergic synapse_Homo sapiens_hsa047250.59126294
115Gap junction_Homo sapiens_hsa045400.58958740
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58801922
117HTLV-I infection_Homo sapiens_hsa051660.58542690
118Salmonella infection_Homo sapiens_hsa051320.56893473
119Hepatitis C_Homo sapiens_hsa051600.56764135
120Notch signaling pathway_Homo sapiens_hsa043300.56756820
121Lysosome_Homo sapiens_hsa041420.56712999
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56698422
123Systemic lupus erythematosus_Homo sapiens_hsa053220.56185196
124Thyroid hormone synthesis_Homo sapiens_hsa049180.55875114
125Alcoholism_Homo sapiens_hsa050340.55835061
126Ras signaling pathway_Homo sapiens_hsa040140.55822985

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