

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.95288306 |
| 2 | layer formation in cerebral cortex (GO:0021819) | 4.89374010 |
| 3 | establishment of mitochondrion localization (GO:0051654) | 4.60252420 |
| 4 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 4.52250077 |
| 5 | mitochondrion transport along microtubule (GO:0047497) | 4.52250077 |
| 6 | nucleobase catabolic process (GO:0046113) | 4.44947720 |
| 7 | axonal fasciculation (GO:0007413) | 4.42516439 |
| 8 | synaptic vesicle maturation (GO:0016188) | 4.19197751 |
| 9 | neuron recognition (GO:0008038) | 4.03486239 |
| 10 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.02792499 |
| 11 | response to pheromone (GO:0019236) | 4.02124049 |
| 12 | regulation of NFAT protein import into nucleus (GO:0051532) | 3.94546499 |
| 13 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.88294964 |
| 14 | sodium ion export (GO:0071436) | 3.86081257 |
| 15 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.81426029 |
| 16 | cell migration in hindbrain (GO:0021535) | 3.79252303 |
| 17 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.75843252 |
| 18 | locomotory exploration behavior (GO:0035641) | 3.52390663 |
| 19 | establishment of nucleus localization (GO:0040023) | 3.51103416 |
| 20 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.44815483 |
| 21 | histone H3-K4 trimethylation (GO:0080182) | 3.34990653 |
| 22 | neuronal ion channel clustering (GO:0045161) | 3.32968300 |
| 23 | pre-miRNA processing (GO:0031054) | 3.32669286 |
| 24 | glutamate secretion (GO:0014047) | 3.32354102 |
| 25 | dendritic spine morphogenesis (GO:0060997) | 3.30568313 |
| 26 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.29161291 |
| 27 | central nervous system neuron axonogenesis (GO:0021955) | 3.16385344 |
| 28 | synaptic vesicle exocytosis (GO:0016079) | 3.16376161 |
| 29 | neurotransmitter secretion (GO:0007269) | 3.16202494 |
| 30 | vocalization behavior (GO:0071625) | 3.14594506 |
| 31 | macroautophagy (GO:0016236) | 3.14483814 |
| 32 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.14079344 |
| 33 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.13898924 |
| 34 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.13163043 |
| 35 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.13163043 |
| 36 | dendrite morphogenesis (GO:0048813) | 3.12496403 |
| 37 | nuclear pore complex assembly (GO:0051292) | 3.11899591 |
| 38 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.07679870 |
| 39 | regulation of RNA export from nucleus (GO:0046831) | 3.06397413 |
| 40 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.06213114 |
| 41 | urea metabolic process (GO:0019627) | 3.06111125 |
| 42 | urea cycle (GO:0000050) | 3.06111125 |
| 43 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.05313046 |
| 44 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.01804778 |
| 45 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.01727817 |
| 46 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.01162100 |
| 47 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.01130061 |
| 48 | glucocorticoid receptor signaling pathway (GO:0042921) | 2.96645806 |
| 49 | regulation of synapse maturation (GO:0090128) | 2.95889178 |
| 50 | positive regulation of synapse maturation (GO:0090129) | 2.94135966 |
| 51 | semaphorin-plexin signaling pathway (GO:0071526) | 2.93901086 |
| 52 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 2.91363492 |
| 53 | L-phenylalanine catabolic process (GO:0006559) | 2.91363492 |
| 54 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 2.88531556 |
| 55 | activation of protein kinase A activity (GO:0034199) | 2.87222312 |
| 56 | histone H3-K36 demethylation (GO:0070544) | 2.87035798 |
| 57 | gamma-aminobutyric acid transport (GO:0015812) | 2.85369502 |
| 58 | RNA localization (GO:0006403) | 2.85285240 |
| 59 | peptidyl-lysine dimethylation (GO:0018027) | 2.84916079 |
| 60 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.83676098 |
| 61 | positive regulation of dendrite morphogenesis (GO:0050775) | 2.83672337 |
| 62 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.83474188 |
| 63 | alpha-linolenic acid metabolic process (GO:0036109) | 2.82259019 |
| 64 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.81575387 |
| 65 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.78996004 |
| 66 | peptidyl-threonine phosphorylation (GO:0018107) | 2.78341635 |
| 67 | regulation of ARF protein signal transduction (GO:0032012) | 2.76740216 |
| 68 | exploration behavior (GO:0035640) | 2.73978807 |
| 69 | cerebellar granule cell differentiation (GO:0021707) | 2.72012408 |
| 70 | nuclear pore organization (GO:0006999) | 2.72001206 |
| 71 | mitochondrion localization (GO:0051646) | 2.71695390 |
| 72 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 2.68775241 |
| 73 | L-phenylalanine metabolic process (GO:0006558) | 2.68775241 |
| 74 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.68741535 |
| 75 | protein localization to synapse (GO:0035418) | 2.68694236 |
| 76 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.68312538 |
| 77 | negative regulation of microtubule polymerization (GO:0031115) | 2.68283904 |
| 78 | pore complex assembly (GO:0046931) | 2.67664578 |
| 79 | histone H3-K9 demethylation (GO:0033169) | 2.67119428 |
| 80 | glutamate metabolic process (GO:0006536) | 2.66214357 |
| 81 | nitrogen cycle metabolic process (GO:0071941) | 2.65484291 |
| 82 | cerebellar Purkinje cell layer development (GO:0021680) | 2.65312455 |
| 83 | cell communication by electrical coupling (GO:0010644) | 2.64564915 |
| 84 | sympathetic nervous system development (GO:0048485) | 2.61604894 |
| 85 | presynaptic membrane organization (GO:0097090) | 2.61252815 |
| 86 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.61021910 |
| 87 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 2.60532761 |
| 88 | lysine metabolic process (GO:0006553) | 2.60439906 |
| 89 | lysine catabolic process (GO:0006554) | 2.60439906 |
| 90 | neuromuscular process controlling balance (GO:0050885) | 2.60206780 |
| 91 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.59690036 |
| 92 | high-density lipoprotein particle remodeling (GO:0034375) | 2.59579076 |
| 93 | kynurenine metabolic process (GO:0070189) | 2.59129391 |
| 94 | presynaptic membrane assembly (GO:0097105) | 2.58748103 |
| 95 | mitotic sister chromatid cohesion (GO:0007064) | 2.58166941 |
| 96 | postsynaptic membrane organization (GO:0001941) | 2.56123545 |
| 97 | histone lysine demethylation (GO:0070076) | 2.55586379 |
| 98 | peptidyl-threonine modification (GO:0018210) | 2.55102530 |
| 99 | epoxygenase P450 pathway (GO:0019373) | 2.55018900 |
| 100 | intracellular estrogen receptor signaling pathway (GO:0030520) | 2.54761479 |
| 101 | negative regulation of neurotransmitter secretion (GO:0046929) | 2.54727489 |
| 102 | regulation of synapse structural plasticity (GO:0051823) | 2.53005408 |
| 103 | cellular ketone body metabolic process (GO:0046950) | 2.52478333 |
| 104 | nucleosome disassembly (GO:0006337) | 2.52203473 |
| 105 | protein-DNA complex disassembly (GO:0032986) | 2.52203473 |
| 106 | synaptic vesicle endocytosis (GO:0048488) | 2.51202100 |
| 107 | regulation of histone H3-K27 methylation (GO:0061085) | 2.51151878 |
| 108 | limb bud formation (GO:0060174) | 2.51054212 |
| 109 | dosage compensation (GO:0007549) | 2.50487315 |
| 110 | response to nerve growth factor (GO:1990089) | 2.50484053 |
| 111 | cellular response to nerve growth factor stimulus (GO:1990090) | 2.50484053 |
| 112 | midgut development (GO:0007494) | 2.50230301 |
| 113 | aromatic amino acid family catabolic process (GO:0009074) | 2.50064158 |
| 114 | regulation of synaptic vesicle transport (GO:1902803) | 2.49263995 |
| 115 | organelle transport along microtubule (GO:0072384) | 2.48944606 |
| 116 | negative regulation of cholesterol transport (GO:0032375) | 2.48837580 |
| 117 | negative regulation of sterol transport (GO:0032372) | 2.48837580 |
| 118 | negative regulation of fibrinolysis (GO:0051918) | 2.48799458 |
| 119 | regulation of dendrite morphogenesis (GO:0048814) | 2.48791498 |
| 120 | peptidyl-lysine trimethylation (GO:0018023) | 2.48143601 |
| 121 | proline transport (GO:0015824) | 2.47037325 |
| 122 | mating behavior (GO:0007617) | 2.46682236 |
| 123 | clathrin coat assembly (GO:0048268) | 2.45174467 |
| 124 | drug catabolic process (GO:0042737) | 2.45100599 |
| 125 | intestinal cholesterol absorption (GO:0030299) | 2.45049608 |
| 126 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.44105003 |
| 127 | corticosteroid receptor signaling pathway (GO:0031958) | 2.44075133 |
| 128 | histone demethylation (GO:0016577) | 2.43918909 |
| 129 | histone H3-K9 methylation (GO:0051567) | 2.43509012 |
| 130 | neuron cell-cell adhesion (GO:0007158) | 2.42709582 |
| 131 | phosphatidylinositol phosphorylation (GO:0046854) | 2.42600887 |
| 132 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.41598017 |
| 133 | negative regulation of dendrite development (GO:2000171) | 2.41011761 |
| 134 | cell differentiation in hindbrain (GO:0021533) | 2.40048522 |
| 135 | vesicle transport along microtubule (GO:0047496) | 2.39424914 |
| 136 | peptidyl-lysine methylation (GO:0018022) | 2.39254437 |
| 137 | cellular response to prostaglandin stimulus (GO:0071379) | 2.39197893 |
| 138 | axon extension (GO:0048675) | 2.38992502 |
| 139 | stress granule assembly (GO:0034063) | 2.38720457 |
| 140 | cerebral cortex neuron differentiation (GO:0021895) | 2.38317259 |
| 141 | growth hormone receptor signaling pathway (GO:0060396) | 2.38092821 |
| 142 | amino acid import (GO:0043090) | 2.37658272 |
| 143 | cellular potassium ion homeostasis (GO:0030007) | 2.35586582 |
| 144 | negative regulation of catenin import into nucleus (GO:0035414) | 2.35463108 |
| 145 | intestinal absorption (GO:0050892) | 2.34872887 |
| 146 | regulation of clathrin-mediated endocytosis (GO:2000369) | 2.33030877 |
| 147 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.32122495 |
| 148 | auditory behavior (GO:0031223) | 2.31587441 |
| 149 | nerve growth factor signaling pathway (GO:0038180) | 2.31275373 |
| 150 | prepulse inhibition (GO:0060134) | 2.29922208 |
| 151 | regulation of cholesterol homeostasis (GO:2000188) | 2.29532239 |
| 152 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.28218703 |
| 153 | reverse cholesterol transport (GO:0043691) | 2.27266030 |
| 154 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.26107047 |
| 155 | cholesterol efflux (GO:0033344) | 2.26080422 |
| 156 | neurotransmitter transport (GO:0006836) | 2.25583681 |
| 157 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.24449827 |
| 158 | cell junction maintenance (GO:0034331) | 2.23720383 |
| 159 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.22458864 |
| 160 | ketone body metabolic process (GO:1902224) | 2.21200694 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 4.99260728 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.50543685 |
| 3 | * MYC_22102868_ChIP-Seq_BL_Human | 3.23481448 |
| 4 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.59692404 |
| 5 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.49929522 |
| 6 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.31542250 |
| 7 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.30513857 |
| 8 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.23290433 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.21461138 |
| 10 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.10788915 |
| 11 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.04497891 |
| 12 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 2.00780940 |
| 13 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.00183799 |
| 14 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.00183799 |
| 15 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.99965491 |
| 16 | * PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.98368664 |
| 17 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.97924869 |
| 18 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.94331962 |
| 19 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.91647906 |
| 20 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.91121760 |
| 21 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.88342353 |
| 22 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.88205196 |
| 23 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.87399642 |
| 24 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.82995252 |
| 25 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.79543680 |
| 26 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.79293464 |
| 27 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.79144487 |
| 28 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.79098627 |
| 29 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.77703589 |
| 30 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.77336096 |
| 31 | KDM2B_26808549_Chip-Seq_K562_Human | 1.74876277 |
| 32 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.74835494 |
| 33 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.74521617 |
| 34 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.74516188 |
| 35 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.70344422 |
| 36 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.70259235 |
| 37 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.69619693 |
| 38 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.68967135 |
| 39 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.68023916 |
| 40 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.67688411 |
| 41 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.65739054 |
| 42 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.65206025 |
| 43 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.64732139 |
| 44 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.64529880 |
| 45 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.59605777 |
| 46 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.56934410 |
| 47 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.55361296 |
| 48 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.53654167 |
| 49 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.51636035 |
| 50 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.50890099 |
| 51 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.50711929 |
| 52 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.49881994 |
| 53 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.46865002 |
| 54 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.42637320 |
| 55 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.41004219 |
| 56 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.39947980 |
| 57 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.38297876 |
| 58 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.34612047 |
| 59 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.34231030 |
| 60 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.34200278 |
| 61 | GATA1_22025678_ChIP-Seq_K562_Human | 1.33086577 |
| 62 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.33036326 |
| 63 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.32682028 |
| 64 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.30287294 |
| 65 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.29143265 |
| 66 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.28978072 |
| 67 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.27902830 |
| 68 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.26456061 |
| 69 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.26139350 |
| 70 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.25959492 |
| 71 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.25767913 |
| 72 | * AR_19668381_ChIP-Seq_PC3_Human | 1.24169628 |
| 73 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.24110610 |
| 74 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.22885375 |
| 75 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.21355195 |
| 76 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.19384456 |
| 77 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.19216535 |
| 78 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.18632879 |
| 79 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.16611801 |
| 80 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.16164582 |
| 81 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.14979806 |
| 82 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.14719305 |
| 83 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.13824460 |
| 84 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.13568049 |
| 85 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.10222999 |
| 86 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.08352257 |
| 87 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.07915375 |
| 88 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.07745462 |
| 89 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 1.07360106 |
| 90 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.06754340 |
| 91 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.06598140 |
| 92 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.05635105 |
| 93 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.05574085 |
| 94 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.05100258 |
| 95 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.04556425 |
| 96 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.04333446 |
| 97 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.04092161 |
| 98 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.03900600 |
| 99 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.03039497 |
| 100 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.02303893 |
| 101 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.02264312 |
| 102 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.01506373 |
| 103 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.01398316 |
| 104 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.00871247 |
| 105 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.97961819 |
| 106 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.97240377 |
| 107 | RXR_22108803_ChIP-Seq_LS180_Human | 0.97167221 |
| 108 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.95611696 |
| 109 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.95207513 |
| 110 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.94715550 |
| 111 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.94320170 |
| 112 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.94312269 |
| 113 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94312269 |
| 114 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.94284997 |
| 115 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.93739068 |
| 116 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.93517478 |
| 117 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.93035271 |
| 118 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.92848109 |
| 119 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.92508974 |
| 120 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.91856280 |
| 121 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.91537760 |
| 122 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.91232198 |
| 123 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.90703479 |
| 124 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.90693884 |
| 125 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.90406169 |
| 126 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.89337066 |
| 127 | * LXR_22292898_ChIP-Seq_THP-1_Human | 0.88900646 |
| 128 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.88544777 |
| 129 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.87669925 |
| 130 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.87652529 |
| 131 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.86883169 |
| 132 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.86498648 |
| 133 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.85979353 |
| 134 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.85384234 |
| 135 | POU3F1_26484290_ChIP-Seq_ESCss_Mouse | 0.85086399 |
| 136 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.84526941 |
| 137 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.84173678 |
| 138 | * SOX9_26525672_Chip-Seq_HEART_Mouse | 0.83524391 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 4.92385280 |
| 2 | MP0005360_urolithiasis | 4.15392786 |
| 3 | MP0005423_abnormal_somatic_nervous | 3.64520823 |
| 4 | MP0002139_abnormal_hepatobiliary_system | 3.62386641 |
| 5 | MP0008057_abnormal_DNA_replication | 2.99422972 |
| 6 | MP0002009_preneoplasia | 2.93574962 |
| 7 | MP0004270_analgesia | 2.82904517 |
| 8 | MP0003635_abnormal_synaptic_transmissio | 2.71957728 |
| 9 | MP0000778_abnormal_nervous_system | 2.70524647 |
| 10 | MP0003122_maternal_imprinting | 2.54985175 |
| 11 | MP0005085_abnormal_gallbladder_physiolo | 2.51958260 |
| 12 | MP0003880_abnormal_central_pattern | 2.47595426 |
| 13 | MP0002063_abnormal_learning/memory/cond | 2.32894290 |
| 14 | MP0003252_abnormal_bile_duct | 2.32127210 |
| 15 | MP0010234_abnormal_vibrissa_follicle | 2.29753014 |
| 16 | MP0000569_abnormal_digit_pigmentation | 2.23082918 |
| 17 | MP0005365_abnormal_bile_salt | 2.22065399 |
| 18 | MP0001348_abnormal_lacrimal_gland | 2.12601739 |
| 19 | MP0001346_abnormal_lacrimal_gland | 2.05042965 |
| 20 | MP0003329_amyloid_beta_deposits | 1.96120302 |
| 21 | MP0003705_abnormal_hypodermis_morpholog | 1.92339168 |
| 22 | MP0002064_seizures | 1.88139612 |
| 23 | MP0002138_abnormal_hepatobiliary_system | 1.87841876 |
| 24 | MP0009046_muscle_twitch | 1.82600628 |
| 25 | MP0005187_abnormal_penis_morphology | 1.80864628 |
| 26 | MP0009745_abnormal_behavioral_response | 1.80716884 |
| 27 | MP0004811_abnormal_neuron_physiology | 1.79656338 |
| 28 | MP0008961_abnormal_basal_metabolism | 1.78265504 |
| 29 | MP0000537_abnormal_urethra_morphology | 1.71757215 |
| 30 | MP0001666_abnormal_nutrient_absorption | 1.67018055 |
| 31 | MP0002653_abnormal_ependyma_morphology | 1.64162910 |
| 32 | MP0002184_abnormal_innervation | 1.62804723 |
| 33 | MP0000955_abnormal_spinal_cord | 1.62455423 |
| 34 | MP0009780_abnormal_chondrocyte_physiolo | 1.60607348 |
| 35 | MP0010329_abnormal_lipoprotein_level | 1.58061242 |
| 36 | MP0003123_paternal_imprinting | 1.57627711 |
| 37 | MP0003183_abnormal_peptide_metabolism | 1.57601021 |
| 38 | MP0008875_abnormal_xenobiotic_pharmacok | 1.53383770 |
| 39 | MP0002733_abnormal_thermal_nociception | 1.53058902 |
| 40 | MP0001486_abnormal_startle_reflex | 1.52611584 |
| 41 | MP0004858_abnormal_nervous_system | 1.51265382 |
| 42 | MP0002734_abnormal_mechanical_nocicepti | 1.50964911 |
| 43 | MP0002572_abnormal_emotion/affect_behav | 1.48592448 |
| 44 | MP0004885_abnormal_endolymph | 1.44662722 |
| 45 | MP0002909_abnormal_adrenal_gland | 1.42151999 |
| 46 | MP0003121_genomic_imprinting | 1.41036583 |
| 47 | MP0000604_amyloidosis | 1.36816570 |
| 48 | MP0005248_abnormal_Harderian_gland | 1.34389745 |
| 49 | MP0000566_synostosis | 1.33227556 |
| 50 | MP0005623_abnormal_meninges_morphology | 1.32499326 |
| 51 | MP0002166_altered_tumor_susceptibility | 1.31738616 |
| 52 | MP0006276_abnormal_autonomic_nervous | 1.28749196 |
| 53 | MP0001968_abnormal_touch/_nociception | 1.26191260 |
| 54 | MP0004742_abnormal_vestibular_system | 1.23272288 |
| 55 | MP0001440_abnormal_grooming_behavior | 1.22821821 |
| 56 | MP0002254_reproductive_system_inflammat | 1.20520766 |
| 57 | MP0002751_abnormal_autonomic_nervous | 1.18086568 |
| 58 | MP0003283_abnormal_digestive_organ | 1.17591334 |
| 59 | MP0002882_abnormal_neuron_morphology | 1.15406746 |
| 60 | MP0002152_abnormal_brain_morphology | 1.15379353 |
| 61 | MP0005409_darkened_coat_color | 1.13961592 |
| 62 | MP0003221_abnormal_cardiomyocyte_apopto | 1.13256991 |
| 63 | MP0005083_abnormal_biliary_tract | 1.13102853 |
| 64 | MP0002272_abnormal_nervous_system | 1.11268500 |
| 65 | MP0003787_abnormal_imprinting | 1.10140461 |
| 66 | MP0002822_catalepsy | 1.09374414 |
| 67 | MP0005386_behavior/neurological_phenoty | 1.08137163 |
| 68 | MP0004924_abnormal_behavior | 1.08137163 |
| 69 | MP0003632_abnormal_nervous_system | 1.08042874 |
| 70 | MP0009115_abnormal_fat_cell | 1.07748253 |
| 71 | MP0010030_abnormal_orbit_morphology | 1.07215676 |
| 72 | MP0002735_abnormal_chemical_nociception | 1.05678930 |
| 73 | MP0002557_abnormal_social/conspecific_i | 1.05245604 |
| 74 | MP0002066_abnormal_motor_capabilities/c | 1.03384556 |
| 75 | MP0001970_abnormal_pain_threshold | 1.01150008 |
| 76 | MP0005076_abnormal_cell_differentiation | 1.00312583 |
| 77 | MP0004264_abnormal_extraembryonic_tissu | 0.99401820 |
| 78 | MP0008569_lethality_at_weaning | 0.98596822 |
| 79 | MP0004185_abnormal_adipocyte_glucose | 0.98535870 |
| 80 | MP0003861_abnormal_nervous_system | 0.98030678 |
| 81 | MP0002736_abnormal_nociception_after | 0.97475381 |
| 82 | MP0003690_abnormal_glial_cell | 0.96717846 |
| 83 | MP0005645_abnormal_hypothalamus_physiol | 0.95878199 |
| 84 | MP0003634_abnormal_glial_cell | 0.92606515 |
| 85 | MP0003091_abnormal_cell_migration | 0.90844869 |
| 86 | MP0010770_preweaning_lethality | 0.90036564 |
| 87 | MP0002082_postnatal_lethality | 0.90036564 |
| 88 | MP0002069_abnormal_eating/drinking_beha | 0.90020828 |
| 89 | MP0002067_abnormal_sensory_capabilities | 0.89852202 |
| 90 | MP0002081_perinatal_lethality | 0.89736612 |
| 91 | MP0009840_abnormal_foam_cell | 0.89297585 |
| 92 | MP0002638_abnormal_pupillary_reflex | 0.88112673 |
| 93 | MP0001529_abnormal_vocalization | 0.87262464 |
| 94 | MP0009053_abnormal_anal_canal | 0.87144075 |
| 95 | MP0003119_abnormal_digestive_system | 0.87049758 |
| 96 | MP0001849_ear_inflammation | 0.86868850 |
| 97 | MP0000534_abnormal_ureter_morphology | 0.86759153 |
| 98 | MP0009672_abnormal_birth_weight | 0.84445421 |
| 99 | MP0003172_abnormal_lysosome_physiology | 0.83690128 |
| 100 | MP0010769_abnormal_survival | 0.83428326 |
| 101 | MP0010768_mortality/aging | 0.80286974 |
| 102 | MP0000631_abnormal_neuroendocrine_gland | 0.79878199 |
| 103 | MP0003631_nervous_system_phenotype | 0.79834472 |
| 104 | MP0005332_abnormal_amino_acid | 0.79255825 |
| 105 | MP0003890_abnormal_embryonic-extraembry | 0.78081340 |
| 106 | MP0001943_abnormal_respiration | 0.77296074 |
| 107 | MP0001986_abnormal_taste_sensitivity | 0.77013159 |
| 108 | MP0001299_abnormal_eye_distance/ | 0.76820096 |
| 109 | MP0001502_abnormal_circadian_rhythm | 0.76742908 |
| 110 | MP0001177_atelectasis | 0.76644141 |
| 111 | MP0004130_abnormal_muscle_cell | 0.76607237 |
| 112 | MP0002118_abnormal_lipid_homeostasis | 0.75153130 |
| 113 | MP0003938_abnormal_ear_development | 0.74810094 |
| 114 | MP0003868_abnormal_feces_composition | 0.71873045 |
| 115 | MP0004142_abnormal_muscle_tone | 0.71572934 |
| 116 | MP0000003_abnormal_adipose_tissue | 0.70804458 |
| 117 | MP0000920_abnormal_myelination | 0.68525626 |
| 118 | MP0005499_abnormal_olfactory_system | 0.68366008 |
| 119 | MP0005394_taste/olfaction_phenotype | 0.68366008 |
| 120 | MP0000371_diluted_coat_color | 0.68206639 |
| 121 | MP0002089_abnormal_postnatal_growth/wei | 0.67809801 |
| 122 | MP0001984_abnormal_olfaction | 0.67605368 |
| 123 | MP0005448_abnormal_energy_balance | 0.67274366 |
| 124 | MP0003866_abnormal_defecation | 0.65907722 |
| 125 | MP0005646_abnormal_pituitary_gland | 0.65540198 |
| 126 | MP0002234_abnormal_pharynx_morphology | 0.65479581 |
| 127 | MP0001270_distended_abdomen | 0.64773757 |
| 128 | MP0003633_abnormal_nervous_system | 0.64714561 |
| 129 | MP0005666_abnormal_adipose_tissue | 0.64441116 |
| 130 | MP0003656_abnormal_erythrocyte_physiolo | 0.64057764 |
| 131 | MP0003942_abnormal_urinary_system | 0.63569412 |
| 132 | MP0000462_abnormal_digestive_system | 0.63275965 |
| 133 | MP0003115_abnormal_respiratory_system | 0.63264332 |
| 134 | MP0000609_abnormal_liver_physiology | 0.63051165 |
| 135 | MP0008874_decreased_physiological_sensi | 0.62689188 |
| 136 | MP0001501_abnormal_sleep_pattern | 0.61719734 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 3.64616549 |
| 2 | Abnormality of the lower motor neuron (HP:0002366) | 3.39749316 |
| 3 | Deep venous thrombosis (HP:0002625) | 3.25463997 |
| 4 | Hyperventilation (HP:0002883) | 3.11813366 |
| 5 | Focal seizures (HP:0007359) | 3.07755696 |
| 6 | Termporal pattern (HP:0011008) | 3.06201318 |
| 7 | Insidious onset (HP:0003587) | 3.06201318 |
| 8 | Asymmetry of the thorax (HP:0001555) | 2.93458747 |
| 9 | Urinary urgency (HP:0000012) | 2.88700767 |
| 10 | Supranuclear gaze palsy (HP:0000605) | 2.86109361 |
| 11 | Abnormality of the corticospinal tract (HP:0002492) | 2.85442774 |
| 12 | Focal motor seizures (HP:0011153) | 2.83555833 |
| 13 | Hyperacusis (HP:0010780) | 2.77026412 |
| 14 | Abnormal eating behavior (HP:0100738) | 2.73566893 |
| 15 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.72299625 |
| 16 | Insomnia (HP:0100785) | 2.72165629 |
| 17 | Spastic gait (HP:0002064) | 2.72115944 |
| 18 | Ankle clonus (HP:0011448) | 2.68786332 |
| 19 | Cerebral inclusion bodies (HP:0100314) | 2.63644526 |
| 20 | Deep palmar crease (HP:0006191) | 2.60324754 |
| 21 | Elfin facies (HP:0004428) | 2.58635811 |
| 22 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.57349285 |
| 23 | Flat acetabular roof (HP:0003180) | 2.54010486 |
| 24 | Macroorchidism (HP:0000053) | 2.53450111 |
| 25 | Renovascular hypertension (HP:0100817) | 2.52823923 |
| 26 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.51719823 |
| 27 | Action tremor (HP:0002345) | 2.51451074 |
| 28 | Impaired social interactions (HP:0000735) | 2.51270002 |
| 29 | Abnormal social behavior (HP:0012433) | 2.51270002 |
| 30 | Hypobetalipoproteinemia (HP:0003563) | 2.50320155 |
| 31 | Cortical dysplasia (HP:0002539) | 2.49007043 |
| 32 | Turricephaly (HP:0000262) | 2.46969334 |
| 33 | Amyotrophic lateral sclerosis (HP:0007354) | 2.43327154 |
| 34 | Failure to thrive in infancy (HP:0001531) | 2.42306856 |
| 35 | Intrahepatic cholestasis (HP:0001406) | 2.41350142 |
| 36 | Visual hallucinations (HP:0002367) | 2.40844842 |
| 37 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.38212122 |
| 38 | Hypoplasia of the brainstem (HP:0002365) | 2.38212122 |
| 39 | High anterior hairline (HP:0009890) | 2.27346106 |
| 40 | Germ cell neoplasia (HP:0100728) | 2.27203433 |
| 41 | Poor eye contact (HP:0000817) | 2.26378594 |
| 42 | Xanthomatosis (HP:0000991) | 2.26161218 |
| 43 | Epidermoid cyst (HP:0200040) | 2.23905917 |
| 44 | Excessive salivation (HP:0003781) | 2.23263913 |
| 45 | Drooling (HP:0002307) | 2.23263913 |
| 46 | Clonus (HP:0002169) | 2.23037373 |
| 47 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.22991042 |
| 48 | Intention tremor (HP:0002080) | 2.17131666 |
| 49 | Pointed chin (HP:0000307) | 2.16984172 |
| 50 | Overriding aorta (HP:0002623) | 2.16310243 |
| 51 | Papilledema (HP:0001085) | 2.14711013 |
| 52 | Atonic seizures (HP:0010819) | 2.13582194 |
| 53 | Shawl scrotum (HP:0000049) | 2.13170355 |
| 54 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.12979834 |
| 55 | Absence seizures (HP:0002121) | 2.11215715 |
| 56 | Menstrual irregularities (HP:0000858) | 2.08390209 |
| 57 | Renal duplication (HP:0000075) | 2.07740554 |
| 58 | Neurofibrillary tangles (HP:0002185) | 2.06903819 |
| 59 | Lower limb muscle weakness (HP:0007340) | 2.05746331 |
| 60 | Thickened helices (HP:0000391) | 2.05609301 |
| 61 | Dysmetric saccades (HP:0000641) | 2.05283614 |
| 62 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.04978439 |
| 63 | Status epilepticus (HP:0002133) | 2.03700989 |
| 64 | Neonatal hypoglycemia (HP:0001998) | 2.03609800 |
| 65 | Skin nodule (HP:0200036) | 2.02668083 |
| 66 | Megalencephaly (HP:0001355) | 2.02664486 |
| 67 | Long clavicles (HP:0000890) | 2.01564242 |
| 68 | Torticollis (HP:0000473) | 2.00939378 |
| 69 | Abnormality of the fingertips (HP:0001211) | 1.99717002 |
| 70 | Hepatoblastoma (HP:0002884) | 1.99501935 |
| 71 | Lower limb asymmetry (HP:0100559) | 1.99072821 |
| 72 | Buphthalmos (HP:0000557) | 1.98742600 |
| 73 | Progressive cerebellar ataxia (HP:0002073) | 1.97273829 |
| 74 | Pseudobulbar signs (HP:0002200) | 1.97096223 |
| 75 | Truncal ataxia (HP:0002078) | 1.94728381 |
| 76 | Spastic paraplegia (HP:0001258) | 1.94716669 |
| 77 | Epileptic encephalopathy (HP:0200134) | 1.92879612 |
| 78 | Exotropia (HP:0000577) | 1.91198706 |
| 79 | Smooth philtrum (HP:0000319) | 1.90439116 |
| 80 | Overlapping toe (HP:0001845) | 1.90354175 |
| 81 | Open mouth (HP:0000194) | 1.90155312 |
| 82 | Amblyopia (HP:0000646) | 1.89438574 |
| 83 | Heterotopia (HP:0002282) | 1.88971445 |
| 84 | Partial agenesis of the corpus callosum (HP:0001338) | 1.88725202 |
| 85 | Alacrima (HP:0000522) | 1.88515082 |
| 86 | Paraplegia (HP:0010550) | 1.88023872 |
| 87 | Lymphangioma (HP:0100764) | 1.87869172 |
| 88 | Hypoplasia of the corpus callosum (HP:0002079) | 1.86820281 |
| 89 | Abnormality of proline metabolism (HP:0010907) | 1.86042314 |
| 90 | Hydroxyprolinuria (HP:0003080) | 1.86042314 |
| 91 | Subacute progressive viral hepatitis (HP:0006572) | 1.84216148 |
| 92 | Broad-based gait (HP:0002136) | 1.83833922 |
| 93 | Dysmetria (HP:0001310) | 1.83133717 |
| 94 | Upper limb amyotrophy (HP:0009129) | 1.82481443 |
| 95 | Distal upper limb amyotrophy (HP:0007149) | 1.82481443 |
| 96 | Hemiplegia (HP:0002301) | 1.82231198 |
| 97 | Hypsarrhythmia (HP:0002521) | 1.81292201 |
| 98 | Protruding tongue (HP:0010808) | 1.80110367 |
| 99 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.80092375 |
| 100 | Hand muscle atrophy (HP:0009130) | 1.79937668 |
| 101 | Disproportionate tall stature (HP:0001519) | 1.79574889 |
| 102 | Growth hormone excess (HP:0000845) | 1.78274981 |
| 103 | Uterine leiomyosarcoma (HP:0002891) | 1.77593159 |
| 104 | Leiomyosarcoma (HP:0100243) | 1.77593159 |
| 105 | Colitis (HP:0002583) | 1.77284242 |
| 106 | Megalocornea (HP:0000485) | 1.76580419 |
| 107 | Generalized tonic-clonic seizures (HP:0002069) | 1.75719995 |
| 108 | EEG with generalized epileptiform discharges (HP:0011198) | 1.75189598 |
| 109 | Hammertoe (HP:0001765) | 1.74728389 |
| 110 | Depression (HP:0000716) | 1.74600391 |
| 111 | Abnormality of the intervertebral disk (HP:0005108) | 1.74388960 |
| 112 | Back pain (HP:0003418) | 1.74253824 |
| 113 | Curly hair (HP:0002212) | 1.74154104 |
| 114 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.73606885 |
| 115 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.73606885 |
| 116 | Genetic anticipation (HP:0003743) | 1.73334345 |
| 117 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.73301084 |
| 118 | Papillary thyroid carcinoma (HP:0002895) | 1.73051435 |
| 119 | Spastic diplegia (HP:0001264) | 1.72736293 |
| 120 | Complement deficiency (HP:0004431) | 1.72252393 |
| 121 | Peripheral hypomyelination (HP:0007182) | 1.72166158 |
| 122 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.71935177 |
| 123 | Scanning speech (HP:0002168) | 1.71558785 |
| 124 | Sacral dimple (HP:0000960) | 1.71281837 |
| 125 | Aqueductal stenosis (HP:0002410) | 1.71159541 |
| 126 | Neonatal onset (HP:0003623) | 1.71135510 |
| 127 | Impulsivity (HP:0100710) | 1.70972279 |
| 128 | Spastic tetraplegia (HP:0002510) | 1.70888857 |
| 129 | Abnormality of the gastric mucosa (HP:0004295) | 1.70327712 |
| 130 | Ankyloglossia (HP:0010296) | 1.70058164 |
| 131 | Patellar dislocation (HP:0002999) | 1.69747158 |
| 132 | Dialeptic seizures (HP:0011146) | 1.69018795 |
| 133 | Epileptiform EEG discharges (HP:0011182) | 1.68966786 |
| 134 | Abnormality of the periventricular white matter (HP:0002518) | 1.68713259 |
| 135 | Gout (HP:0001997) | 1.68662986 |
| 136 | Obsessive-compulsive behavior (HP:0000722) | 1.68488713 |
| 137 | Polyphagia (HP:0002591) | 1.68414424 |
| 138 | Cubitus valgus (HP:0002967) | 1.67996311 |
| 139 | Focal dystonia (HP:0004373) | 1.67157574 |
| 140 | Obstructive sleep apnea (HP:0002870) | 1.67145279 |
| 141 | Long toe (HP:0010511) | 1.65972793 |
| 142 | Hepatocellular carcinoma (HP:0001402) | 1.65888385 |
| 143 | Bladder neoplasm (HP:0009725) | 1.65693709 |
| 144 | Bladder carcinoma (HP:0002862) | 1.65693709 |
| 145 | Broad palm (HP:0001169) | 1.65674632 |
| 146 | Abnormality of the sella turcica (HP:0002679) | 1.65266375 |
| 147 | Blue irides (HP:0000635) | 1.65206247 |
| 148 | Trigonocephaly (HP:0000243) | 1.65047099 |
| 149 | Viral hepatitis (HP:0006562) | 1.64777726 |
| 150 | Vertebral arch anomaly (HP:0008438) | 1.64060011 |
| 151 | Prominent forehead (HP:0011220) | 1.63544412 |
| 152 | Abnormality of chromosome segregation (HP:0002916) | 1.63541339 |
| 153 | Febrile seizures (HP:0002373) | 1.63412367 |
| 154 | Thick eyebrow (HP:0000574) | 1.63064663 |
| 155 | Visceral angiomatosis (HP:0100761) | 1.60884625 |
| 156 | Hemangiomatosis (HP:0007461) | 1.60606829 |
| 157 | Abnormality of salivation (HP:0100755) | 1.60044446 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K9 | 3.98499729 |
| 2 | CASK | 3.44634852 |
| 3 | MARK1 | 3.32924843 |
| 4 | EPHA3 | 2.65621172 |
| 5 | NTRK3 | 2.42838917 |
| 6 | PAK6 | 2.31444578 |
| 7 | KSR1 | 2.31040874 |
| 8 | MINK1 | 2.20952796 |
| 9 | KSR2 | 2.12846280 |
| 10 | ICK | 2.04653009 |
| 11 | MAP3K4 | 2.03697724 |
| 12 | RIPK1 | 2.02413794 |
| 13 | FGFR2 | 1.77348134 |
| 14 | PRKD3 | 1.69061173 |
| 15 | TRIB3 | 1.68277736 |
| 16 | MAP3K13 | 1.68116834 |
| 17 | BCR | 1.65781868 |
| 18 | TYRO3 | 1.57370448 |
| 19 | SIK2 | 1.57114001 |
| 20 | EPHA4 | 1.55461793 |
| 21 | MAP2K4 | 1.54236643 |
| 22 | LATS2 | 1.54045306 |
| 23 | UHMK1 | 1.45423329 |
| 24 | DAPK2 | 1.45012604 |
| 25 | SGK2 | 1.41104196 |
| 26 | SCYL2 | 1.39823786 |
| 27 | NTRK1 | 1.37959188 |
| 28 | NTRK2 | 1.37915892 |
| 29 | PAK3 | 1.32919440 |
| 30 | PTK6 | 1.29075918 |
| 31 | RET | 1.28954541 |
| 32 | PDGFRA | 1.27132532 |
| 33 | SMG1 | 1.27108947 |
| 34 | MARK2 | 1.25835359 |
| 35 | MAPK11 | 1.20942517 |
| 36 | AKT3 | 1.18410921 |
| 37 | NEK1 | 1.17862687 |
| 38 | ERN1 | 1.17808858 |
| 39 | ERBB2 | 1.14512216 |
| 40 | CDK5 | 1.13929793 |
| 41 | BMX | 1.13369825 |
| 42 | CAMKK1 | 1.06358841 |
| 43 | PRPF4B | 1.05469393 |
| 44 | SIK3 | 1.04126376 |
| 45 | CDK12 | 1.02803994 |
| 46 | SIK1 | 1.00456396 |
| 47 | FGFR4 | 0.99497676 |
| 48 | CAMK1G | 0.97709537 |
| 49 | MAP3K2 | 0.97355261 |
| 50 | PRKCZ | 0.97039952 |
| 51 | RPS6KA2 | 0.93192381 |
| 52 | CLK1 | 0.90919392 |
| 53 | DDR2 | 0.89784456 |
| 54 | MAP3K10 | 0.88590767 |
| 55 | ALK | 0.87406878 |
| 56 | PTK2 | 0.86698926 |
| 57 | PIK3CA | 0.82504359 |
| 58 | TESK1 | 0.82373900 |
| 59 | WNK1 | 0.79987320 |
| 60 | MAP3K7 | 0.79339852 |
| 61 | RPS6KB1 | 0.73851681 |
| 62 | PKN2 | 0.73221536 |
| 63 | YES1 | 0.73219752 |
| 64 | CAMK4 | 0.72805662 |
| 65 | SGK3 | 0.72279584 |
| 66 | LIMK1 | 0.71549863 |
| 67 | SGK494 | 0.71321937 |
| 68 | SGK223 | 0.71321937 |
| 69 | CSNK1G2 | 0.70606468 |
| 70 | MAPK13 | 0.69722332 |
| 71 | FRK | 0.69538209 |
| 72 | MAP3K14 | 0.69534491 |
| 73 | SRPK1 | 0.68714377 |
| 74 | STK11 | 0.68476110 |
| 75 | CDK18 | 0.68335295 |
| 76 | EPHB2 | 0.68286790 |
| 77 | TNIK | 0.68184769 |
| 78 | MAP2K2 | 0.68093636 |
| 79 | PRKCH | 0.65994681 |
| 80 | STK38 | 0.64761563 |
| 81 | CDK15 | 0.62347828 |
| 82 | FGFR1 | 0.62251426 |
| 83 | PKN1 | 0.61530816 |
| 84 | CDK14 | 0.60369098 |
| 85 | MAP3K6 | 0.59857077 |
| 86 | CSNK1A1L | 0.59638842 |
| 87 | PDK1 | 0.59523743 |
| 88 | FER | 0.59485202 |
| 89 | CDC42BPA | 0.59270490 |
| 90 | EEF2K | 0.59138467 |
| 91 | BRD4 | 0.58906352 |
| 92 | LMTK2 | 0.58619745 |
| 93 | MTOR | 0.58515722 |
| 94 | CAMK1D | 0.58505711 |
| 95 | JAK2 | 0.58400582 |
| 96 | ROCK1 | 0.57655345 |
| 97 | RPS6KB2 | 0.57383292 |
| 98 | ERBB3 | 0.57004507 |
| 99 | JAK1 | 0.56583356 |
| 100 | ROCK2 | 0.56479424 |
| 101 | MAP2K1 | 0.54052220 |
| 102 | FGFR3 | 0.53697881 |
| 103 | SGK1 | 0.52861125 |
| 104 | MAP2K7 | 0.52251733 |
| 105 | PHKG1 | 0.50587389 |
| 106 | PHKG2 | 0.50587389 |
| 107 | DAPK1 | 0.50511080 |
| 108 | IRAK2 | 0.50152764 |
| 109 | DYRK1B | 0.48052254 |
| 110 | DYRK2 | 0.47996826 |
| 111 | PDPK1 | 0.46991423 |
| 112 | PRKCG | 0.46767077 |
| 113 | GSK3B | 0.46336573 |
| 114 | NEK6 | 0.46107341 |
| 115 | MAPK8 | 0.45417502 |
| 116 | CDK4 | 0.44874785 |
| 117 | CDK11A | 0.44811852 |
| 118 | PDGFRB | 0.44467195 |
| 119 | FYN | 0.44308044 |
| 120 | WNK3 | 0.43862520 |
| 121 | PRKAA1 | 0.43343059 |
| 122 | RPS6KA3 | 0.43322561 |
| 123 | RIPK4 | 0.42611411 |
| 124 | OXSR1 | 0.42607524 |
| 125 | MAPK10 | 0.42261623 |
| 126 | CDK2 | 0.41636644 |
| 127 | LATS1 | 0.41365235 |
| 128 | CSNK1D | 0.41029053 |
| 129 | CDK6 | 0.40665389 |
| 130 | PASK | 0.40594310 |
| 131 | DYRK1A | 0.38317022 |
| 132 | CHUK | 0.36156234 |
| 133 | CDK3 | 0.36134112 |
| 134 | MAPK12 | 0.35689224 |
| 135 | CDK1 | 0.34601236 |
| 136 | MAPK14 | 0.34288267 |
| 137 | PRKDC | 0.34265933 |
| 138 | MAPK9 | 0.32909512 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.61839614 |
| 2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.28609778 |
| 3 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.40464856 |
| 4 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.01970638 |
| 5 | Bile secretion_Homo sapiens_hsa04976 | 1.80466148 |
| 6 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.74938264 |
| 7 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.74658218 |
| 8 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.69798418 |
| 9 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.68923707 |
| 10 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.67654569 |
| 11 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.63946233 |
| 12 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.63391039 |
| 13 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.53560177 |
| 14 | Axon guidance_Homo sapiens_hsa04360 | 1.52892027 |
| 15 | GABAergic synapse_Homo sapiens_hsa04727 | 1.49126234 |
| 16 | Nicotine addiction_Homo sapiens_hsa05033 | 1.38794626 |
| 17 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.36244171 |
| 18 | Long-term potentiation_Homo sapiens_hsa04720 | 1.32602649 |
| 19 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.32059395 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.31334830 |
| 21 | Circadian entrainment_Homo sapiens_hsa04713 | 1.27443586 |
| 22 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.26008026 |
| 23 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.25432554 |
| 24 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.24485267 |
| 25 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.21526826 |
| 26 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.19869881 |
| 27 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.14833940 |
| 28 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.13451190 |
| 29 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.11917600 |
| 30 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.10479381 |
| 31 | Endometrial cancer_Homo sapiens_hsa05213 | 1.06676626 |
| 32 | Alcoholism_Homo sapiens_hsa05034 | 1.05742194 |
| 33 | * Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.05243546 |
| 34 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.04926936 |
| 35 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.04628328 |
| 36 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.04148446 |
| 37 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.03821464 |
| 38 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.02720685 |
| 39 | Morphine addiction_Homo sapiens_hsa05032 | 1.02297263 |
| 40 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.01737799 |
| 41 | Glioma_Homo sapiens_hsa05214 | 1.00963106 |
| 42 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.00033177 |
| 43 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.99614572 |
| 44 | Prostate cancer_Homo sapiens_hsa05215 | 0.99019125 |
| 45 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.98908622 |
| 46 | Salivary secretion_Homo sapiens_hsa04970 | 0.97912834 |
| 47 | Olfactory transduction_Homo sapiens_hsa04740 | 0.97662389 |
| 48 | Gap junction_Homo sapiens_hsa04540 | 0.97453746 |
| 49 | Insulin secretion_Homo sapiens_hsa04911 | 0.97125597 |
| 50 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.96356601 |
| 51 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.91030143 |
| 52 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.90506015 |
| 53 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.88301054 |
| 54 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.88132715 |
| 55 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.85683513 |
| 56 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.84134152 |
| 57 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.83824901 |
| 58 | Renin secretion_Homo sapiens_hsa04924 | 0.81885051 |
| 59 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.81718571 |
| 60 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.81375811 |
| 61 | Cocaine addiction_Homo sapiens_hsa05030 | 0.80504067 |
| 62 | Hepatitis B_Homo sapiens_hsa05161 | 0.79692228 |
| 63 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.79511494 |
| 64 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.79288992 |
| 65 | Lysine degradation_Homo sapiens_hsa00310 | 0.78773505 |
| 66 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.77942574 |
| 67 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.77248671 |
| 68 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.75206562 |
| 69 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.73485052 |
| 70 | Thyroid cancer_Homo sapiens_hsa05216 | 0.73461321 |
| 71 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.73062010 |
| 72 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.71599275 |
| 73 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.71401171 |
| 74 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.70908807 |
| 75 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.70589189 |
| 76 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.69926394 |
| 77 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.69317775 |
| 78 | Long-term depression_Homo sapiens_hsa04730 | 0.69014687 |
| 79 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.66505781 |
| 80 | Prion diseases_Homo sapiens_hsa05020 | 0.66070895 |
| 81 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.65892814 |
| 82 | * Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.65846625 |
| 83 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.65694476 |
| 84 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.65030963 |
| 85 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.64901244 |
| 86 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.64638852 |
| 87 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.64479732 |
| 88 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.64391439 |
| 89 | Melanogenesis_Homo sapiens_hsa04916 | 0.64295096 |
| 90 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.64100143 |
| 91 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.63789948 |
| 92 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.63354058 |
| 93 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.63102140 |
| 94 | Hepatitis C_Homo sapiens_hsa05160 | 0.61131110 |
| 95 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.61060973 |
| 96 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.61043718 |
| 97 | Insulin resistance_Homo sapiens_hsa04931 | 0.61024825 |
| 98 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.59188464 |
| 99 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.58918013 |
| 100 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.58855405 |
| 101 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.58803654 |
| 102 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.57204668 |
| 103 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.55122506 |
| 104 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.55043945 |
| 105 | ABC transporters_Homo sapiens_hsa02010 | 0.54950616 |
| 106 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.54474052 |
| 107 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.53743939 |
| 108 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.53580498 |
| 109 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.52828775 |
| 110 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.52412132 |
| 111 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.51762500 |
| 112 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.50740954 |
| 113 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.49623836 |
| 114 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.48830265 |
| 115 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.48582711 |
| 116 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.47111263 |
| 117 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.46224406 |
| 118 | Endocytosis_Homo sapiens_hsa04144 | 0.46179916 |
| 119 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.45580448 |
| 120 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.45432406 |
| 121 | Colorectal cancer_Homo sapiens_hsa05210 | 0.45218610 |
| 122 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.44910373 |
| 123 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.44852147 |
| 124 | Tight junction_Homo sapiens_hsa04530 | 0.43996833 |
| 125 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.43486237 |
| 126 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.43068172 |
| 127 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.42772587 |
| 128 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.42504630 |
| 129 | Taste transduction_Homo sapiens_hsa04742 | 0.41954470 |
| 130 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.38708556 |
| 131 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.37658172 |
| 132 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.37644477 |

