MTMR7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.34264303
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34086619
3synaptic vesicle exocytosis (GO:0016079)5.32742313
4regulation of synaptic vesicle exocytosis (GO:2000300)5.07894681
5glutamate secretion (GO:0014047)4.91401250
6synaptic vesicle maturation (GO:0016188)4.63845193
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.63250568
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.55969254
9vocalization behavior (GO:0071625)4.45025942
10regulation of synaptic vesicle transport (GO:1902803)4.44622418
11neuron cell-cell adhesion (GO:0007158)4.34559926
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.28540169
13negative regulation of cytosolic calcium ion concentration (GO:0051481)4.24332363
14pyrimidine nucleobase catabolic process (GO:0006208)4.22077130
15nucleobase catabolic process (GO:0046113)4.18178817
16neurotransmitter secretion (GO:0007269)4.17108273
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.14397899
18locomotory exploration behavior (GO:0035641)4.10158241
19protein localization to synapse (GO:0035418)4.03116673
20dendritic spine morphogenesis (GO:0060997)4.00417239
21regulation of glutamate receptor signaling pathway (GO:1900449)3.97644108
22neurotransmitter-gated ion channel clustering (GO:0072578)3.88844739
23neuronal action potential propagation (GO:0019227)3.85030268
24detection of calcium ion (GO:0005513)3.81120990
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78346951
26neuron-neuron synaptic transmission (GO:0007270)3.75391696
27positive regulation of synapse maturation (GO:0090129)3.65512817
28synaptic transmission, glutamatergic (GO:0035249)3.60091061
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59644459
30cellular ketone body metabolic process (GO:0046950)3.57999587
31striatum development (GO:0021756)3.56263362
32axonal fasciculation (GO:0007413)3.53374467
33negative regulation of dendrite development (GO:2000171)3.52278128
34brain morphogenesis (GO:0048854)3.51367223
35long-term synaptic potentiation (GO:0060291)3.51063174
36synaptic vesicle endocytosis (GO:0048488)3.39461702
37regulation of neuronal synaptic plasticity (GO:0048168)3.39420366
38cerebellar Purkinje cell differentiation (GO:0021702)3.38822733
39innervation (GO:0060384)3.37678746
40presynaptic membrane assembly (GO:0097105)3.36646518
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.34403730
42insulin secretion (GO:0030073)3.33616801
43neurotransmitter transport (GO:0006836)3.33606169
44positive regulation of membrane potential (GO:0045838)3.33050697
45regulation of vesicle fusion (GO:0031338)3.32639704
46glycosphingolipid biosynthetic process (GO:0006688)3.32145360
47postsynaptic membrane organization (GO:0001941)3.23996613
48glutamate receptor signaling pathway (GO:0007215)3.20281250
49exploration behavior (GO:0035640)3.19722400
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.19055891
51regulation of neurotransmitter secretion (GO:0046928)3.16921214
52activation of protein kinase A activity (GO:0034199)3.16382347
53regulation of calcium ion-dependent exocytosis (GO:0017158)3.15887781
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15692631
55regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15204743
56regulation of type B pancreatic cell apoptotic process (GO:2000674)3.14537853
57ketone body metabolic process (GO:1902224)3.11962835
58presynaptic membrane organization (GO:0097090)3.11284240
59regulation of synapse maturation (GO:0090128)3.11057096
60proline transport (GO:0015824)3.09483131
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08181136
62glycerophospholipid catabolic process (GO:0046475)3.06975589
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.06586105
64regulation of synaptic plasticity (GO:0048167)3.06336524
65membrane depolarization during action potential (GO:0086010)3.05594466
66calcium ion-dependent exocytosis (GO:0017156)3.05425612
67behavioral response to cocaine (GO:0048148)3.04339446
68positive regulation of exocytosis (GO:0045921)3.04206441
69long-term memory (GO:0007616)3.03772436
70regulation of synapse structural plasticity (GO:0051823)3.02402770
71regulation of neurotransmitter transport (GO:0051588)3.01225870
72negative regulation of dendrite morphogenesis (GO:0050774)3.00034058
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99714238
74regulation of exocytosis (GO:0017157)2.99460752
75synaptic vesicle transport (GO:0048489)2.99436262
76establishment of synaptic vesicle localization (GO:0097480)2.99436262
77synapse assembly (GO:0007416)2.99162473
78vesicle transport along microtubule (GO:0047496)2.99119200
79neuromuscular process controlling posture (GO:0050884)2.99064760
80regulation of postsynaptic membrane potential (GO:0060078)2.98449584
81response to histamine (GO:0034776)2.97958935
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96898946
83transferrin transport (GO:0033572)2.96679006
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95631213
85adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.93771991
86regulation of neurotransmitter levels (GO:0001505)2.93209625
87regulation of cAMP-dependent protein kinase activity (GO:2000479)2.89918786
88behavioral response to ethanol (GO:0048149)2.89130544
89mechanosensory behavior (GO:0007638)2.88447246
90signal release (GO:0023061)2.87815520
91organelle transport along microtubule (GO:0072384)2.87426646
92transmission of nerve impulse (GO:0019226)2.87058359
93synaptic transmission (GO:0007268)2.86681256
94establishment of vesicle localization (GO:0051650)2.85746824
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83963246
96energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.83569461
97ATP hydrolysis coupled proton transport (GO:0015991)2.83569461
98auditory behavior (GO:0031223)2.82987326
99membrane hyperpolarization (GO:0060081)2.81150312
100gamma-aminobutyric acid transport (GO:0015812)2.80940892
101regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.80608838
102regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.80608838
103* inositol phosphate catabolic process (GO:0071545)2.80580033
104neuron recognition (GO:0008038)2.79991773
105neuronal ion channel clustering (GO:0045161)2.78872928
106long term synaptic depression (GO:0060292)2.78754579
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78321310
108G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78090343
109positive regulation of neurotransmitter transport (GO:0051590)2.77808862
110positive regulation of synaptic transmission (GO:0050806)2.77735409
111response to auditory stimulus (GO:0010996)2.77289945
112startle response (GO:0001964)2.77252686
113ferric iron transport (GO:0015682)2.76718769
114trivalent inorganic cation transport (GO:0072512)2.76718769
115COPI coating of Golgi vesicle (GO:0048205)2.74745721
116establishment of mitochondrion localization (GO:0051654)2.72656813
117alanine transport (GO:0032328)2.70490273
118nonmotile primary cilium assembly (GO:0035058)2.67376563
119dendrite morphogenesis (GO:0048813)2.64594822
120prepulse inhibition (GO:0060134)2.62195626
121atrial cardiac muscle cell action potential (GO:0086014)2.60662257
122regulation of dendritic spine morphogenesis (GO:0061001)2.59119270
123positive regulation of amino acid transport (GO:0051957)2.58085743
124endocrine pancreas development (GO:0031018)2.57851202
125epithelial cell fate commitment (GO:0072148)2.57405555
126behavioral response to nicotine (GO:0035095)2.57242773
127protein localization to cilium (GO:0061512)2.54694156
128regulation of cilium movement (GO:0003352)2.53351387
129chemosensory behavior (GO:0007635)2.51896696
130establishment of protein localization to Golgi (GO:0072600)2.50911237
131calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.50137590
132regulation of microtubule-based movement (GO:0060632)2.50044493
133regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.49487951
134calcium ion import (GO:0070509)2.48796226
135serotonin metabolic process (GO:0042428)2.47086251
136righting reflex (GO:0060013)2.46587189
137macroautophagy (GO:0016236)2.46323716
138synapse organization (GO:0050808)2.43893472
139positive regulation of insulin secretion (GO:0032024)2.42990918
140protein targeting to Golgi (GO:0000042)2.42620837
141dendritic spine organization (GO:0097061)2.41609148
142response to pheromone (GO:0019236)2.41438223
143auditory receptor cell differentiation (GO:0042491)2.40694593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.87409575
2GBX2_23144817_ChIP-Seq_PC3_Human4.47096734
3REST_21632747_ChIP-Seq_MESCs_Mouse3.00087846
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49222492
5REST_18959480_ChIP-ChIP_MESCs_Mouse2.47659823
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43969556
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39067735
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.33198326
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26413669
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26387747
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18862465
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18118991
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14965582
14TAF15_26573619_Chip-Seq_HEK293_Human2.12118167
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06982034
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02766790
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00895467
18SMAD4_21799915_ChIP-Seq_A2780_Human1.97316727
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.97281542
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97030461
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92692702
22DROSHA_22980978_ChIP-Seq_HELA_Human1.91278064
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90634878
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84862034
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.84391843
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82649351
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76498352
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75981615
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75620590
30IGF1R_20145208_ChIP-Seq_DFB_Human1.73357709
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70900162
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68817955
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68195196
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68195196
35STAT3_23295773_ChIP-Seq_U87_Human1.67159966
36P300_19829295_ChIP-Seq_ESCs_Human1.66930134
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64745603
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64670643
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.61458249
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.61237628
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.58728471
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58226815
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.57322898
44* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56676585
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53442140
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52704033
47EWS_26573619_Chip-Seq_HEK293_Human1.50974731
48* SOX2_21211035_ChIP-Seq_LN229_Gbm1.47597312
49RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.47537170
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45929750
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.45910931
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.45304876
53TCF4_23295773_ChIP-Seq_U87_Human1.44909658
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.41920017
55RNF2_27304074_Chip-Seq_NSC_Mouse1.40722800
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39704365
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38719259
58CBP_20019798_ChIP-Seq_JUKART_Human1.38719259
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37549656
60ZNF274_21170338_ChIP-Seq_K562_Hela1.37219738
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37120538
62BCAT_22108803_ChIP-Seq_LS180_Human1.36645486
63FUS_26573619_Chip-Seq_HEK293_Human1.36608396
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36346142
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35956605
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35784069
67VDR_22108803_ChIP-Seq_LS180_Human1.32139638
68AR_25329375_ChIP-Seq_VCAP_Human1.30323503
69* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26769880
70CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.24112642
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24010297
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.22977866
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21687161
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21240376
75AR_19668381_ChIP-Seq_PC3_Human1.20201364
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19093143
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.17757863
78HTT_18923047_ChIP-ChIP_STHdh_Human1.17403387
79TP53_22573176_ChIP-Seq_HFKS_Human1.17326722
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.16607115
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15042420
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14914879
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14887161
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14882097
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14852407
86RUNX2_22187159_ChIP-Seq_PCA_Human1.14156292
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13735359
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13533509
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11812441
90TCF4_22108803_ChIP-Seq_LS180_Human1.09850363
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08225157
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08030121
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.07393590
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07193975
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.06991145
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.06106055
97REST_19997604_ChIP-ChIP_NEURONS_Mouse1.06081355
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06045667
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05287439
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.04913160
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04328146
102AR_21572438_ChIP-Seq_LNCaP_Human1.03840452
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02463433
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.01972693
105JUN_21703547_ChIP-Seq_K562_Human1.01596242
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01593285
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.01213036
108P300_18555785_Chip-Seq_ESCs_Mouse1.00933214
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99323398
110P53_22387025_ChIP-Seq_ESCs_Mouse0.99019980
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97264958
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.97126963
113TBL1_22424771_ChIP-Seq_293T_Human0.97072768
114CMYC_18555785_Chip-Seq_ESCs_Mouse0.97048771
115HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96548596
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96169598
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95938864
118AHR_22903824_ChIP-Seq_MCF-7_Human0.95477237
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94316927
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93386433
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93174823
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92848585
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92688528
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91568824
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91257448
126ER_23166858_ChIP-Seq_MCF-7_Human0.90663107
127CBX2_27304074_Chip-Seq_ESCs_Mouse0.90656873
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89659423
129SOX2_18555785_Chip-Seq_ESCs_Mouse0.89636031
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89500512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.52233534
2MP0004270_analgesia3.83000153
3MP0003880_abnormal_central_pattern3.66134033
4MP0003635_abnormal_synaptic_transmissio3.39560168
5MP0001968_abnormal_touch/_nociception2.84124707
6MP0002063_abnormal_learning/memory/cond2.78063825
7MP0002734_abnormal_mechanical_nocicepti2.76592636
8MP0009745_abnormal_behavioral_response2.73293758
9MP0009046_muscle_twitch2.60453944
10MP0002064_seizures2.53563089
11MP0002909_abnormal_adrenal_gland2.49789570
12MP0002572_abnormal_emotion/affect_behav2.48082507
13MP0002822_catalepsy2.45812195
14MP0010386_abnormal_urinary_bladder2.45223812
15MP0002735_abnormal_chemical_nociception2.37976646
16MP0002272_abnormal_nervous_system2.31534736
17MP0002736_abnormal_nociception_after2.25673293
18MP0001984_abnormal_olfaction2.25157613
19MP0003787_abnormal_imprinting2.24277896
20MP0002733_abnormal_thermal_nociception2.13086302
21MP0005646_abnormal_pituitary_gland2.10075989
22MP0006276_abnormal_autonomic_nervous2.04622354
23MP0009780_abnormal_chondrocyte_physiolo2.03976195
24MP0001486_abnormal_startle_reflex2.00750312
25MP0003183_abnormal_peptide_metabolism1.98405647
26MP0003283_abnormal_digestive_organ1.94803402
27MP0005645_abnormal_hypothalamus_physiol1.94201350
28MP0003122_maternal_imprinting1.92774347
29MP0000013_abnormal_adipose_tissue1.91194464
30MP0001970_abnormal_pain_threshold1.91090798
31MP0002067_abnormal_sensory_capabilities1.89323290
32MP0001501_abnormal_sleep_pattern1.87714709
33MP0004043_abnormal_pH_regulation1.85796010
34MP0001529_abnormal_vocalization1.79920985
35MP0002184_abnormal_innervation1.79817475
36MP0005423_abnormal_somatic_nervous1.75237757
37MP0001440_abnormal_grooming_behavior1.70998931
38MP0001986_abnormal_taste_sensitivity1.66925319
39MP0003879_abnormal_hair_cell1.66154581
40MP0002557_abnormal_social/conspecific_i1.65033535
41MP0002837_dystrophic_cardiac_calcinosis1.64699226
42MP0005386_behavior/neurological_phenoty1.59601906
43MP0004924_abnormal_behavior1.59601906
44MP0004811_abnormal_neuron_physiology1.55710945
45MP0001502_abnormal_circadian_rhythm1.54634361
46MP0001188_hyperpigmentation1.49943223
47MP0000955_abnormal_spinal_cord1.47412435
48MP0002102_abnormal_ear_morphology1.46641008
49MP0006072_abnormal_retinal_apoptosis1.46414849
50MP0004858_abnormal_nervous_system1.44265962
51MP0002693_abnormal_pancreas_physiology1.42781897
52MP0000778_abnormal_nervous_system1.42680738
53MP0000569_abnormal_digit_pigmentation1.40880729
54MP0002638_abnormal_pupillary_reflex1.38251146
55MP0008569_lethality_at_weaning1.34748851
56MP0005379_endocrine/exocrine_gland_phen1.34351744
57MP0002876_abnormal_thyroid_physiology1.30517392
58MP0002882_abnormal_neuron_morphology1.28753001
59MP0005551_abnormal_eye_electrophysiolog1.25519289
60MP0008877_abnormal_DNA_methylation1.24037810
61MP0000678_abnormal_parathyroid_gland1.19859746
62MP0003121_genomic_imprinting1.19597527
63MP0002066_abnormal_motor_capabilities/c1.18839147
64MP0002877_abnormal_melanocyte_morpholog1.18439940
65MP0001944_abnormal_pancreas_morphology1.13973838
66MP0000631_abnormal_neuroendocrine_gland1.13459642
67MP0003123_paternal_imprinting1.10857360
68MP0002163_abnormal_gland_morphology1.10187034
69MP0002229_neurodegeneration1.08103351
70MP0005499_abnormal_olfactory_system1.06190321
71MP0005394_taste/olfaction_phenotype1.06190321
72MP0004147_increased_porphyrin_level1.03103776
73MP0003329_amyloid_beta_deposits1.00398984
74MP0002653_abnormal_ependyma_morphology0.99250926
75MP0001905_abnormal_dopamine_level0.98727621
76MP0004215_abnormal_myocardial_fiber0.98651208
77MP0005084_abnormal_gallbladder_morpholo0.97558339
78MP0004142_abnormal_muscle_tone0.95630389
79MP0002928_abnormal_bile_duct0.95213980
80MP0002152_abnormal_brain_morphology0.95087577
81MP0003633_abnormal_nervous_system0.94264775
82MP0002069_abnormal_eating/drinking_beha0.94037652
83MP0003690_abnormal_glial_cell0.93799531
84MP0003890_abnormal_embryonic-extraembry0.91932265
85MP0000639_abnormal_adrenal_gland0.89354132
86MP0005253_abnormal_eye_physiology0.89133564
87MP0002751_abnormal_autonomic_nervous0.88643740
88MP0005220_abnormal_exocrine_pancreas0.88409595
89MP0005535_abnormal_body_temperature0.88372920
90MP0000427_abnormal_hair_cycle0.87989296
91MP0004742_abnormal_vestibular_system0.87317663
92MP0002078_abnormal_glucose_homeostasis0.85690545
93MP0000516_abnormal_urinary_system0.83698513
94MP0005367_renal/urinary_system_phenotyp0.83698513
95MP0003195_calcinosis0.79906798
96MP0002090_abnormal_vision0.78604876
97MP0001485_abnormal_pinna_reflex0.78582496
98MP0003631_nervous_system_phenotype0.78025311
99MP0008961_abnormal_basal_metabolism0.77553709
100MP0001963_abnormal_hearing_physiology0.76682791
101MP0001756_abnormal_urination0.74829613
102MP0002752_abnormal_somatic_nervous0.73957188
103MP0008872_abnormal_physiological_respon0.73881288
104MP0006292_abnormal_olfactory_placode0.73650967
105MP0003953_abnormal_hormone_level0.72971216
106MP0010329_abnormal_lipoprotein_level0.72650387
107MP0010234_abnormal_vibrissa_follicle0.71951990
108MP0002234_abnormal_pharynx_morphology0.69349004
109MP0004145_abnormal_muscle_electrophysio0.68978239
110MP0004264_abnormal_extraembryonic_tissu0.68387324
111MP0003119_abnormal_digestive_system0.67834444
112MP0000003_abnormal_adipose_tissue0.66560832
113MP0004085_abnormal_heartbeat0.66044874
114MP0004885_abnormal_endolymph0.64524343
115MP0004133_heterotaxia0.63877271
116MP0002160_abnormal_reproductive_system0.63477115
117MP0001664_abnormal_digestion0.62988001
118MP0004233_abnormal_muscle_weight0.62714830

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.82600499
2Epileptic encephalopathy (HP:0200134)4.58940013
3Myokymia (HP:0002411)4.47161731
4Febrile seizures (HP:0002373)4.36053402
5Atonic seizures (HP:0010819)4.35974539
6Focal seizures (HP:0007359)4.28506948
7Visual hallucinations (HP:0002367)4.18218901
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.97812081
9Absence seizures (HP:0002121)3.66202850
10Progressive cerebellar ataxia (HP:0002073)3.55935126
11Dialeptic seizures (HP:0011146)3.32555440
12Intestinal atresia (HP:0011100)3.30562060
13Epileptiform EEG discharges (HP:0011182)3.21361209
14Generalized tonic-clonic seizures (HP:0002069)3.21121310
15Gait imbalance (HP:0002141)3.15579974
16EEG with generalized epileptiform discharges (HP:0011198)3.09227010
17Hypoglycemic coma (HP:0001325)3.03120773
18Pheochromocytoma (HP:0002666)2.94816929
19Hyperventilation (HP:0002883)2.91252670
20Hypsarrhythmia (HP:0002521)2.91065087
21Congenital primary aphakia (HP:0007707)2.88665396
22Amblyopia (HP:0000646)2.76369875
23Medial flaring of the eyebrow (HP:0010747)2.68597754
24Gaze-evoked nystagmus (HP:0000640)2.64954056
25Action tremor (HP:0002345)2.64443791
26Neuroendocrine neoplasm (HP:0100634)2.64338079
27Abnormality of calcium-phosphate metabolism (HP:0100530)2.63482895
28Nephrogenic diabetes insipidus (HP:0009806)2.63477868
29Impaired smooth pursuit (HP:0007772)2.62798100
30Congenital malformation of the right heart (HP:0011723)2.62567702
31Double outlet right ventricle (HP:0001719)2.62567702
32Hyperinsulinemic hypoglycemia (HP:0000825)2.61634218
33Failure to thrive in infancy (HP:0001531)2.59927057
34Ankle clonus (HP:0011448)2.59342204
35Hypothermia (HP:0002045)2.56724192
36Truncal ataxia (HP:0002078)2.56282343
37Depression (HP:0000716)2.54996557
38Symptomatic seizures (HP:0011145)2.53615364
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.44769535
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.44769535
41Abnormality of the corticospinal tract (HP:0002492)2.44006242
42Limb dystonia (HP:0002451)2.43824344
43Broad-based gait (HP:0002136)2.36520415
44Abnormality of the labia minora (HP:0012880)2.35975858
45Methylmalonic acidemia (HP:0002912)2.34739377
46Impaired vibration sensation in the lower limbs (HP:0002166)2.34721103
47Agitation (HP:0000713)2.33649167
48Excessive salivation (HP:0003781)2.31664613
49Drooling (HP:0002307)2.31664613
50Aqueductal stenosis (HP:0002410)2.30482638
51Poor eye contact (HP:0000817)2.29292318
52Urinary bladder sphincter dysfunction (HP:0002839)2.27079588
53Ketoacidosis (HP:0001993)2.23914985
54Absent speech (HP:0001344)2.23701005
55Resting tremor (HP:0002322)2.22561206
56Dysdiadochokinesis (HP:0002075)2.22559803
57Poor coordination (HP:0002370)2.22297708
58Abnormal eating behavior (HP:0100738)2.20650864
59Status epilepticus (HP:0002133)2.20279655
60Genital tract atresia (HP:0001827)2.19328687
61Intention tremor (HP:0002080)2.18461184
62Specific learning disability (HP:0001328)2.17963790
63Abnormality of vitamin B metabolism (HP:0004340)2.17831680
64Supranuclear gaze palsy (HP:0000605)2.17590700
65Spastic tetraplegia (HP:0002510)2.17546143
66Cortical visual impairment (HP:0100704)2.14882971
67Vaginal atresia (HP:0000148)2.14723625
68Anxiety (HP:0000739)2.13912477
69Abnormality of ocular smooth pursuit (HP:0000617)2.12406088
70Inability to walk (HP:0002540)2.11947179
71Hypoglycemic seizures (HP:0002173)2.11595111
72Dysautonomia (HP:0002459)2.11552340
73Bradykinesia (HP:0002067)2.08974162
74Neoplasm of the adrenal cortex (HP:0100641)2.08657706
75Abnormal hair whorl (HP:0010721)2.07518666
76Spastic gait (HP:0002064)2.07493419
77Protruding tongue (HP:0010808)2.07169905
78Impaired social interactions (HP:0000735)2.06582906
79Abnormal social behavior (HP:0012433)2.06582906
80Generalized myoclonic seizures (HP:0002123)2.06246779
81Decreased circulating renin level (HP:0003351)2.06173115
82Papillary thyroid carcinoma (HP:0002895)2.04884030
83Hemiparesis (HP:0001269)2.04114044
84Renal cortical cysts (HP:0000803)2.03327749
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02933831
86Pancreatic cysts (HP:0001737)2.02563540
87Blue irides (HP:0000635)1.98926627
88Genetic anticipation (HP:0003743)1.98764848
89Abnormality of the renal cortex (HP:0011035)1.97917323
90Nephronophthisis (HP:0000090)1.97797272
91Molar tooth sign on MRI (HP:0002419)1.94272687
92Abnormality of midbrain morphology (HP:0002418)1.94272687
93Hepatoblastoma (HP:0002884)1.93116321
94Poor suck (HP:0002033)1.92656614
95Volvulus (HP:0002580)1.91392993
96Lissencephaly (HP:0001339)1.91043217
97Type II lissencephaly (HP:0007260)1.89819596
98Postural instability (HP:0002172)1.89187845
99Insulin-resistant diabetes mellitus (HP:0000831)1.88224480
100Abnormality of the lower motor neuron (HP:0002366)1.88033706
101Hypoplasia of the fovea (HP:0007750)1.87588595
102Aplasia/Hypoplasia of the fovea (HP:0008060)1.87588595
103Large for gestational age (HP:0001520)1.87006123
104Abnormality of vitamin metabolism (HP:0100508)1.86833639
105Proximal tubulopathy (HP:0000114)1.86776906
106Polyphagia (HP:0002591)1.86669148
107Muscular hypotonia of the trunk (HP:0008936)1.85326838
108Amyotrophic lateral sclerosis (HP:0007354)1.83961400
109Congenital stationary night blindness (HP:0007642)1.83618027
110True hermaphroditism (HP:0010459)1.83451085
111Labial hypoplasia (HP:0000066)1.82991849
112Dysmetria (HP:0001310)1.81037433
113Central scotoma (HP:0000603)1.80743866
114Clonus (HP:0002169)1.79542269
115Methylmalonic aciduria (HP:0012120)1.79385439
116Dysmetric saccades (HP:0000641)1.79272072
117Pachygyria (HP:0001302)1.78515898
118Abnormality of the fovea (HP:0000493)1.77417148
119Scanning speech (HP:0002168)1.77307239
120Impaired vibratory sensation (HP:0002495)1.76433792
121Tubulointerstitial nephritis (HP:0001970)1.76164892
122Prolonged QT interval (HP:0001657)1.76062685
123Oligomenorrhea (HP:0000876)1.73413236
124Fetal akinesia sequence (HP:0001989)1.73070003
125Abnormality of pain sensation (HP:0010832)1.72522655
126Impaired pain sensation (HP:0007328)1.72522655
127Pancreatic fibrosis (HP:0100732)1.71094152
128Abnormal drinking behavior (HP:0030082)1.70812760
129Polydipsia (HP:0001959)1.70812760
130Ketosis (HP:0001946)1.69594545
131Progressive inability to walk (HP:0002505)1.68870659
132Enlarged penis (HP:0000040)1.68144005
133Retinal dysplasia (HP:0007973)1.66916598
134Hypoplastic female external genitalia (HP:0012815)1.66683436
135Retinal atrophy (HP:0001105)1.66479235
136Hyperglycemia (HP:0003074)1.65452839
137Abnormal rod and cone electroretinograms (HP:0008323)1.64728358
138Postural tremor (HP:0002174)1.63833510
139Papilledema (HP:0001085)1.61322483
140Abnormality of binocular vision (HP:0011514)1.60513001
141Diplopia (HP:0000651)1.60513001
142Hypogonadotrophic hypogonadism (HP:0000044)1.60246975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.14580450
2CASK3.63211158
3MAP3K43.56638792
4MAP3K93.31858375
5EPHA42.78288777
6MAP2K72.77363566
7MARK12.73291371
8MINK12.56213971
9FGFR22.38934332
10AKT32.36484983
11MAP3K122.09684664
12DAPK22.07285236
13PRKD32.00075099
14MAP2K41.81254124
15MAP3K21.78835339
16PAK61.74514834
17INSRR1.74441415
18KSR21.64423071
19MAP4K21.62045720
20SIK31.60668056
21KSR11.55466210
22DAPK11.55298888
23WNK31.53504803
24NTRK11.52729664
25PLK21.51211814
26ARAF1.50430383
27BRAF1.48735342
28NTRK21.48539680
29CAMKK21.45060301
30CSNK1G11.42210258
31TRIM281.38179372
32UHMK11.38099939
33CSNK1G31.32891976
34BMPR21.29801882
35MAPK131.29561454
36CDK51.28197643
37GRK51.25606300
38DYRK21.24737249
39CAMKK11.23879915
40CSNK1A1L1.23225040
41PNCK1.22029255
42SGK21.20054013
43GRK11.19994604
44BCR1.19229829
45SGK4941.16958106
46SGK2231.16958106
47PASK1.13663365
48FRK1.09936763
49TSSK61.07967057
50PRKCG1.06636192
51BMPR1B1.05679966
52PRPF4B1.05459580
53RIPK41.00167970
54EPHA30.99245696
55CCNB10.98867846
56CDK190.98331285
57ACVR1B0.95983745
58CAMK2A0.89363447
59MAPK150.88210707
60CAMK2B0.84289648
61MAP3K10.83753201
62MAP2K60.83666773
63NEK10.78441269
64FER0.78423942
65PRKCE0.76305407
66CDC42BPA0.75061258
67WNK40.73737765
68SCYL20.73547429
69STK380.73457326
70CDK140.72491151
71CDK180.71203022
72SGK30.70604935
73HIPK20.70394911
74RET0.67950931
75BRD40.66822322
76PRKAA10.66099852
77SGK10.65048505
78DYRK1A0.64749869
79TNIK0.64228433
80CAMK2D0.63800384
81ERBB30.63537303
82PRKCZ0.60643084
83CDK150.60525860
84LIMK10.60232366
85LATS20.60074354
86PINK10.59960171
87NEK60.59759899
88IRAK20.59306501
89YES10.58248302
90PAK30.57453727
91PRKCH0.56104571
92CSNK1G20.54915590
93NLK0.53610489
94PLK30.53407477
95WNK10.53224299
96CAMK1G0.53114748
97SIK20.52007944
98CAMK10.51745551
99MARK20.51481374
100CSNK1D0.51077566
101FGFR30.49935039
102ALK0.49894864
103CDK11A0.48959819
104MAP2K10.47448789
105STK390.47292548
106BRSK10.46813923
107PRKG10.46720532
108MKNK20.46567607
109CSNK1A10.46491323
110OXSR10.46341627
111ADRBK10.44726383
112PRKACA0.44723905
113RPS6KA30.44391110
114MAP3K130.43956285
115MAPK100.43728784
116IRAK10.43101330
117FES0.42912408
118PRKACB0.42748308
119PTK2B0.41609479
120RPS6KA20.40839652
121PHKG20.40010781
122PHKG10.40010781
123NME10.39695004
124PRKCI0.39137091
125ZAK0.39108865
126ADRBK20.38783511
127RPS6KB10.38438216
128CAMK2G0.37564070
129GRK70.36384764
130CSNK1E0.36380763
131CAMK40.36360318
132STK38L0.36099313
133STK110.36044896
134PKN10.35369045
135PRKAA20.33747999
136TRPM70.32898899
137PRKCB0.32580004
138BRSK20.31647343
139PRKCA0.30474341

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.96375150
2Nicotine addiction_Homo sapiens_hsa050333.38990999
3Insulin secretion_Homo sapiens_hsa049113.00465977
4Olfactory transduction_Homo sapiens_hsa047402.72394661
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71099036
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.67008222
7GABAergic synapse_Homo sapiens_hsa047272.65749196
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57774968
9Amphetamine addiction_Homo sapiens_hsa050312.57046455
10Collecting duct acid secretion_Homo sapiens_hsa049662.53572072
11Butanoate metabolism_Homo sapiens_hsa006502.48839000
12Circadian entrainment_Homo sapiens_hsa047132.45533200
13Morphine addiction_Homo sapiens_hsa050322.45361717
14Long-term potentiation_Homo sapiens_hsa047202.42126125
15Taste transduction_Homo sapiens_hsa047422.33273825
16Dopaminergic synapse_Homo sapiens_hsa047282.28844276
17Glutamatergic synapse_Homo sapiens_hsa047242.17125577
18Vibrio cholerae infection_Homo sapiens_hsa051102.12358124
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96127137
20Cocaine addiction_Homo sapiens_hsa050301.94532144
21Serotonergic synapse_Homo sapiens_hsa047261.87605331
22Cholinergic synapse_Homo sapiens_hsa047251.80026635
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74995206
24Type II diabetes mellitus_Homo sapiens_hsa049301.71103592
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67968153
26Type I diabetes mellitus_Homo sapiens_hsa049401.58749123
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56471397
28Salivary secretion_Homo sapiens_hsa049701.55494194
29Long-term depression_Homo sapiens_hsa047301.47737536
30Renin secretion_Homo sapiens_hsa049241.39916232
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39583907
32Phototransduction_Homo sapiens_hsa047441.39257722
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24068617
34Protein export_Homo sapiens_hsa030601.21422893
35Gastric acid secretion_Homo sapiens_hsa049711.19256711
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19137221
37Calcium signaling pathway_Homo sapiens_hsa040201.18962017
38Oxytocin signaling pathway_Homo sapiens_hsa049211.14833946
39GnRH signaling pathway_Homo sapiens_hsa049121.14776242
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14284800
41Vitamin B6 metabolism_Homo sapiens_hsa007501.11850374
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08691125
43Gap junction_Homo sapiens_hsa045401.08633882
44* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08218277
45Circadian rhythm_Homo sapiens_hsa047101.06915162
46Estrogen signaling pathway_Homo sapiens_hsa049151.06101283
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06099562
48Oocyte meiosis_Homo sapiens_hsa041141.04908705
49Propanoate metabolism_Homo sapiens_hsa006401.02345410
50Fatty acid elongation_Homo sapiens_hsa000621.02135259
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01860593
52cAMP signaling pathway_Homo sapiens_hsa040241.01434572
53Ether lipid metabolism_Homo sapiens_hsa005651.00969498
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99177358
55Selenocompound metabolism_Homo sapiens_hsa004500.94181464
56Peroxisome_Homo sapiens_hsa041460.93330328
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89879942
58Sphingolipid metabolism_Homo sapiens_hsa006000.89286249
59Folate biosynthesis_Homo sapiens_hsa007900.87536024
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87380826
61Alcoholism_Homo sapiens_hsa050340.86126430
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85615107
63Glucagon signaling pathway_Homo sapiens_hsa049220.84228161
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83967801
65Regulation of autophagy_Homo sapiens_hsa041400.83903412
66Dorso-ventral axis formation_Homo sapiens_hsa043200.83252534
67ErbB signaling pathway_Homo sapiens_hsa040120.82567579
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82267960
69Fatty acid metabolism_Homo sapiens_hsa012120.80690074
70Thyroid hormone synthesis_Homo sapiens_hsa049180.80014713
71Tryptophan metabolism_Homo sapiens_hsa003800.79808565
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.79008681
73beta-Alanine metabolism_Homo sapiens_hsa004100.78900843
74Melanogenesis_Homo sapiens_hsa049160.78286707
75Pancreatic secretion_Homo sapiens_hsa049720.73808213
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72719105
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.72290120
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70584470
79Glioma_Homo sapiens_hsa052140.67665078
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67041748
81Fatty acid biosynthesis_Homo sapiens_hsa000610.64615868
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62367778
83Oxidative phosphorylation_Homo sapiens_hsa001900.61231345
84ABC transporters_Homo sapiens_hsa020100.59718537
85Prion diseases_Homo sapiens_hsa050200.58709088
86Rheumatoid arthritis_Homo sapiens_hsa053230.58569693
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58386293
88MAPK signaling pathway_Homo sapiens_hsa040100.57739539
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57564763
90Basal transcription factors_Homo sapiens_hsa030220.57351100
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55906020
92Axon guidance_Homo sapiens_hsa043600.54380040
93Cardiac muscle contraction_Homo sapiens_hsa042600.53357657
94Steroid biosynthesis_Homo sapiens_hsa001000.51426080
95mTOR signaling pathway_Homo sapiens_hsa041500.49470482
96* Inositol phosphate metabolism_Homo sapiens_hsa005620.48573621
97Endometrial cancer_Homo sapiens_hsa052130.48175325
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47952637
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47807451
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47415816
101Alzheimers disease_Homo sapiens_hsa050100.47176433
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.46716390
103Linoleic acid metabolism_Homo sapiens_hsa005910.46293648
104Nitrogen metabolism_Homo sapiens_hsa009100.44540831
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44476869
106Prolactin signaling pathway_Homo sapiens_hsa049170.43843755
107Insulin signaling pathway_Homo sapiens_hsa049100.43095156
108Choline metabolism in cancer_Homo sapiens_hsa052310.42368733
109Ras signaling pathway_Homo sapiens_hsa040140.41576797
110Phagosome_Homo sapiens_hsa041450.41022360
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38233932
112Fructose and mannose metabolism_Homo sapiens_hsa000510.36163293
113Tight junction_Homo sapiens_hsa045300.35656074
114Arginine biosynthesis_Homo sapiens_hsa002200.34666761
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34623627
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.33834621
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32202373
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32127606
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31842397
120* Metabolic pathways_Homo sapiens_hsa011000.31715198
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31712043
122Huntingtons disease_Homo sapiens_hsa050160.29534493
123N-Glycan biosynthesis_Homo sapiens_hsa005100.29189881
124Ovarian steroidogenesis_Homo sapiens_hsa049130.28362587
125Parkinsons disease_Homo sapiens_hsa050120.28332281
126Wnt signaling pathway_Homo sapiens_hsa043100.27877294
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25022604
128Sulfur metabolism_Homo sapiens_hsa009200.22163636
129Colorectal cancer_Homo sapiens_hsa052100.21514529
130Endocytosis_Homo sapiens_hsa041440.21487565
131Renal cell carcinoma_Homo sapiens_hsa052110.21165716
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18636206
133Dilated cardiomyopathy_Homo sapiens_hsa054140.18105725

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