MTMR9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.58835878
2locomotory exploration behavior (GO:0035641)4.99351500
3presynaptic membrane assembly (GO:0097105)4.91326364
4regulation of translational termination (GO:0006449)4.88553316
5layer formation in cerebral cortex (GO:0021819)4.84575260
6presynaptic membrane organization (GO:0097090)4.73739681
7neuron cell-cell adhesion (GO:0007158)4.63987719
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.53848353
9axonal fasciculation (GO:0007413)4.24296701
10activation of protein kinase A activity (GO:0034199)4.23540296
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.08574877
12neuron recognition (GO:0008038)4.00985394
13postsynaptic membrane organization (GO:0001941)3.89342622
14pre-miRNA processing (GO:0031054)3.86178649
15establishment of nucleus localization (GO:0040023)3.85409509
16behavioral response to nicotine (GO:0035095)3.84478302
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.80694304
18proline transport (GO:0015824)3.80604462
19glutamate secretion (GO:0014047)3.78941321
20pyrimidine nucleobase catabolic process (GO:0006208)3.78680687
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.72034452
22positive regulation of synapse maturation (GO:0090129)3.71354207
23cytoskeletal anchoring at plasma membrane (GO:0007016)3.62825037
24sodium ion export (GO:0071436)3.61997520
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61980333
26regulation of synapse structural plasticity (GO:0051823)3.60749052
27exploration behavior (GO:0035640)3.47833329
28mitochondrion transport along microtubule (GO:0047497)3.45616211
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.45616211
30glutamate receptor signaling pathway (GO:0007215)3.43635126
31regulation of NFAT protein import into nucleus (GO:0051532)3.43464131
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36151202
33clathrin coat assembly (GO:0048268)3.35494130
34central nervous system projection neuron axonogenesis (GO:0021952)3.35460117
35synaptic transmission, glutamatergic (GO:0035249)3.34467343
36protein localization to synapse (GO:0035418)3.30588587
37stress granule assembly (GO:0034063)3.28221246
38nucleobase catabolic process (GO:0046113)3.26126205
39neuromuscular process controlling balance (GO:0050885)3.24112936
40neuronal action potential propagation (GO:0019227)3.22181139
41peptidyl-lysine dimethylation (GO:0018027)3.22097395
42regulation of synaptic vesicle exocytosis (GO:2000300)3.20015347
43regulation of ARF protein signal transduction (GO:0032012)3.19319823
44negative regulation of microtubule polymerization (GO:0031115)3.16442572
45negative regulation of cell size (GO:0045792)3.13371387
46negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.11881230
47negative regulation of translation, ncRNA-mediated (GO:0040033)3.11881230
48regulation of translation, ncRNA-mediated (GO:0045974)3.11881230
49neuron-neuron synaptic transmission (GO:0007270)3.11620790
50atrial cardiac muscle cell action potential (GO:0086014)3.11257711
51neurotransmitter secretion (GO:0007269)3.10147678
52neurotransmitter-gated ion channel clustering (GO:0072578)3.09319277
53neurofilament cytoskeleton organization (GO:0060052)3.09287093
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06444742
55transmission of nerve impulse (GO:0019226)3.02928140
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.01830794
57regulation of clathrin-mediated endocytosis (GO:2000369)3.00863687
58auditory behavior (GO:0031223)3.00331748
59mechanosensory behavior (GO:0007638)2.99744916
60organelle transport along microtubule (GO:0072384)2.99648930
61synaptic vesicle exocytosis (GO:0016079)2.97626776
62cerebral cortex radially oriented cell migration (GO:0021799)2.97097397
63alanine transport (GO:0032328)2.95879205
64glucocorticoid receptor signaling pathway (GO:0042921)2.95805308
65actin filament capping (GO:0051693)2.93115041
66regulation of cAMP-dependent protein kinase activity (GO:2000479)2.92449946
67vocalization behavior (GO:0071625)2.91884076
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91079750
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90577037
70vesicle transport along microtubule (GO:0047496)2.90067923
71synapse assembly (GO:0007416)2.90045032
72axon cargo transport (GO:0008088)2.89108287
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86738040
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.85381269
75central nervous system neuron axonogenesis (GO:0021955)2.85367265
76negative regulation of organelle assembly (GO:1902116)2.84405678
77cytoplasmic mRNA processing body assembly (GO:0033962)2.84065988
78cell communication by electrical coupling (GO:0010644)2.83672953
79regulation of dendritic spine morphogenesis (GO:0061001)2.83043446
80regulation of glutamate receptor signaling pathway (GO:1900449)2.82994263
81startle response (GO:0001964)2.81301496
82peptidyl-arginine omega-N-methylation (GO:0035247)2.81054986
83regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80521580
84dendrite morphogenesis (GO:0048813)2.79465392
85gamma-aminobutyric acid transport (GO:0015812)2.77820182
86neuromuscular synaptic transmission (GO:0007274)2.77526813
87positive regulation of axon extension (GO:0045773)2.77518983
88barbed-end actin filament capping (GO:0051016)2.77306714
89regulation of synaptic vesicle transport (GO:1902803)2.76188411
90epithelial cell differentiation involved in prostate gland development (GO:0060742)2.74763484
91cerebellar Purkinje cell layer development (GO:0021680)2.73795968
92antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.73043782
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.72913448
94cell migration in hindbrain (GO:0021535)2.72042955
95adult walking behavior (GO:0007628)2.71451953
96regulation of long-term neuronal synaptic plasticity (GO:0048169)2.71433984
97alpha-linolenic acid metabolic process (GO:0036109)2.71405565
98positive regulation of synapse assembly (GO:0051965)2.71188308
99nerve growth factor signaling pathway (GO:0038180)2.69620466
100regulation of translational fidelity (GO:0006450)2.68808071
101dendritic spine morphogenesis (GO:0060997)2.68282108
102antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.67661886
103antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.67661886
104regulation of meiosis I (GO:0060631)2.66331103
105positive regulation of fibroblast migration (GO:0010763)2.66295976
106synapse organization (GO:0050808)2.66279880
107cerebellar Purkinje cell differentiation (GO:0021702)2.64841041
108membrane depolarization during action potential (GO:0086010)2.64222550
109negative regulation of synaptic transmission, GABAergic (GO:0032229)2.63906052
110regulation of neuronal synaptic plasticity (GO:0048168)2.62832528
111dicarboxylic acid biosynthetic process (GO:0043650)2.62433357
112negative regulation of sodium ion transport (GO:0010766)2.62093734
113negative regulation of axon extension (GO:0030517)2.60783834
114cochlea development (GO:0090102)2.60485002
115establishment of protein localization to Golgi (GO:0072600)2.59868746
116cellular response to electrical stimulus (GO:0071257)2.58608517
117peptidyl-arginine methylation (GO:0018216)2.58602117
118peptidyl-arginine N-methylation (GO:0035246)2.58602117
119axon extension (GO:0048675)2.58401133
120cellular potassium ion homeostasis (GO:0030007)2.57354427
121response to nerve growth factor (GO:1990089)2.57232416
122cellular response to nerve growth factor stimulus (GO:1990090)2.57232416
123neuronal action potential (GO:0019228)2.56164624
124behavioral fear response (GO:0001662)2.56062291
125behavioral defense response (GO:0002209)2.56062291
126adherens junction assembly (GO:0034333)2.55450026
127behavioral response to ethanol (GO:0048149)2.54714918
128regulation of postsynaptic membrane potential (GO:0060078)2.54376024
129establishment of mitochondrion localization (GO:0051654)2.53990138
130regulation of excitatory postsynaptic membrane potential (GO:0060079)2.52616678
131dopamine receptor signaling pathway (GO:0007212)2.52499566
132regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51776532
133retinal cone cell development (GO:0046549)2.50869588
134NLS-bearing protein import into nucleus (GO:0006607)2.50052929
135neuron projection extension (GO:1990138)2.49890697
136prepulse inhibition (GO:0060134)2.49761654
137inner ear receptor cell development (GO:0060119)2.49205327
138negative regulation of neurotransmitter transport (GO:0051589)2.48798456
139response to auditory stimulus (GO:0010996)2.48753536
140negative regulation of dendrite development (GO:2000171)2.48394087
141innervation (GO:0060384)2.46116544
142glycosphingolipid biosynthetic process (GO:0006688)2.45708330
143glycine transport (GO:0015816)2.45047137
144neuron migration (GO:0001764)2.44538898
145peptidyl-tyrosine autophosphorylation (GO:0038083)2.44454324
146regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.44145660
147spinal cord development (GO:0021510)2.43281873
148retinal ganglion cell axon guidance (GO:0031290)2.43049631
149regulation of synaptic transmission, glutamatergic (GO:0051966)2.42189165
150nuclear pore organization (GO:0006999)2.41795012
151adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.41500811
152regulation of gene silencing by miRNA (GO:0060964)2.40869185
153regulation of gene silencing by RNA (GO:0060966)2.40869185
154regulation of posttranscriptional gene silencing (GO:0060147)2.40869185
155nuclear pore complex assembly (GO:0051292)2.40453626
156regulation of dendritic spine development (GO:0060998)2.39778037
157positive regulation of potassium ion transmembrane transport (GO:1901381)2.39675291
158nonmotile primary cilium assembly (GO:0035058)2.39596106
159hippocampus development (GO:0021766)2.39104087
160negative regulation of actin filament depolymerization (GO:0030835)2.39025668
161membrane depolarization (GO:0051899)2.39006790
162positive regulation of nitric-oxide synthase activity (GO:0051000)2.38913333
163regulation of synapse assembly (GO:0051963)2.38759413
164negative regulation of cell killing (GO:0031342)2.38339889
165negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.38339889
166regulation of early endosome to late endosome transport (GO:2000641)2.38307966
167adult behavior (GO:0030534)2.38303625
168L-alpha-amino acid transmembrane transport (GO:1902475)2.37809524
169fear response (GO:0042596)2.37386921
170regulation of fatty acid beta-oxidation (GO:0031998)2.36351207
171regulation of ARF GTPase activity (GO:0032312)2.35073194
172regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.34943883
173CDP-diacylglycerol metabolic process (GO:0046341)2.34123461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.54935705
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.51340242
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.19933835
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.12705091
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.08051241
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.95562835
7E2F7_22180533_ChIP-Seq_HELA_Human2.95154247
8MYC_22102868_ChIP-Seq_BL_Human2.91371534
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80181615
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.76826490
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.75435936
12KDM2B_26808549_Chip-Seq_DND41_Human2.65490998
13ZNF263_19887448_ChIP-Seq_K562_Human2.61758704
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54936328
15TAF15_26573619_Chip-Seq_HEK293_Human2.43677765
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41852557
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37731076
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.34806723
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26310297
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.25681186
21P300_19829295_ChIP-Seq_ESCs_Human2.24821587
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.24591065
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23946271
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.22989306
25FUS_26573619_Chip-Seq_HEK293_Human2.21047547
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16999721
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13629788
28ZNF274_21170338_ChIP-Seq_K562_Hela2.13478929
29KDM2B_26808549_Chip-Seq_K562_Human2.11524872
30EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.08430517
31IGF1R_20145208_ChIP-Seq_DFB_Human2.07936700
32* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.07246869
33TCF7_22412390_ChIP-Seq_EML_Mouse2.07000050
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03726283
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00874170
36VDR_22108803_ChIP-Seq_LS180_Human1.95825699
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.94845145
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.94422536
39LXR_22292898_ChIP-Seq_THP-1_Human1.93443018
40EWS_26573619_Chip-Seq_HEK293_Human1.92513586
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90559302
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.88443835
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86774589
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86384522
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.86038340
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.85341182
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84974262
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84789357
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80772010
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80724260
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.77948402
52SMAD4_21799915_ChIP-Seq_A2780_Human1.77382232
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71184066
54DROSHA_22980978_ChIP-Seq_HELA_Human1.70751221
55* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.68046076
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67929448
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.65603274
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.65224939
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.65171048
60RNF2_27304074_Chip-Seq_NSC_Mouse1.62407294
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.60362079
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60092028
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60006762
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59381516
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58974979
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58974979
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56516393
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55882137
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54690988
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51938077
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50930793
72* REST_18959480_ChIP-ChIP_MESCs_Mouse1.50808342
73STAT3_23295773_ChIP-Seq_U87_Human1.50720329
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50238240
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49455145
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48425930
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48361394
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47222900
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44995632
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.44683270
81* REST_21632747_ChIP-Seq_MESCs_Mouse1.44497694
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.44490476
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43508244
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41059409
85EZH2_22144423_ChIP-Seq_EOC_Human1.40805309
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39813933
87VDR_21846776_ChIP-Seq_THP-1_Human1.39330925
88AR_25329375_ChIP-Seq_VCAP_Human1.37283665
89* TCF4_23295773_ChIP-Seq_U87_Human1.36639104
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.35387785
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32695849
92CREB1_26743006_Chip-Seq_LNCaP_Human1.31380210
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30761371
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30536689
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.29999745
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29783585
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29161168
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28858538
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28418976
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26906709
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26491984
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26193866
103CBP_20019798_ChIP-Seq_JUKART_Human1.26193866
104RNF2_27304074_Chip-Seq_ESCs_Mouse1.25121661
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24718186
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24406287
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23425014
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22536639
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21879759
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.21543305
111SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21312180
112RUNX2_22187159_ChIP-Seq_PCA_Human1.20718278
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.20216383
114RACK7_27058665_Chip-Seq_MCF-7_Human1.19567501
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19455572
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18723679
117ER_23166858_ChIP-Seq_MCF-7_Human1.18477896
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18272052
119RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18249266
120EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18249266
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17931708
122P68_20966046_ChIP-Seq_HELA_Human1.17267609
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17056328
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16902128
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16881487
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16317583
127FLI1_21867929_ChIP-Seq_TH2_Mouse1.16236315
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16051657
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15971277
130SPI1_23127762_ChIP-Seq_K562_Human1.15796318
131AR_21572438_ChIP-Seq_LNCaP_Human1.15781521
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15616340
133ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15579215
134SOX9_26525672_Chip-Seq_HEART_Mouse1.15234021
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14721539
136* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14184088
137TP53_22127205_ChIP-Seq_IMR90_Human1.13598663
138SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13262034
139ATF3_27146783_Chip-Seq_COLON_Human1.13048637
140NFE2_27457419_Chip-Seq_LIVER_Mouse1.12661033
141SMC4_20622854_ChIP-Seq_HELA_Human1.11879057
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11843228
143E2F1_18555785_Chip-Seq_ESCs_Mouse1.11842890
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11563727
145RXR_22158963_ChIP-Seq_LIVER_Mouse1.11478075
146* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11248274
147P53_22387025_ChIP-Seq_ESCs_Mouse1.10855356
148CLOCK_20551151_ChIP-Seq_293T_Human1.09980163
149SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09138782
150BCAT_22108803_ChIP-Seq_LS180_Human1.08354424
151NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07821889
152HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07540672
153CMYC_18555785_Chip-Seq_ESCs_Mouse1.07473710
154ELF1_20517297_ChIP-Seq_JURKAT_Human1.07118891
155RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06306585
156KDM2B_26808549_Chip-Seq_REH_Human1.06131224
157FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05691655
158ERG_21242973_ChIP-ChIP_JURKAT_Human1.05596576
159TET1_21490601_ChIP-Seq_MESCs_Mouse1.05546042
160WT1_19549856_ChIP-ChIP_CCG9911_Human1.05524832
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04405619
162JUN_21703547_ChIP-Seq_K562_Human1.04171460
163GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.04168752
164E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03962881
165SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03924747
166CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03633676
167SMAD4_21741376_ChIP-Seq_EPCs_Human1.02780916
168MAF_26560356_Chip-Seq_TH1_Human1.01835779
169* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01788255
170NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01397212
171CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01258684
172UTX_26944678_Chip-Seq_JUKART_Human1.00686008
173NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96630403
174PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96622635
175CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96606696
176ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95863662
177KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95842444
178NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95565023
179KLF4_19829295_ChIP-Seq_ESCs_Human0.93507875
180ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92809123
181NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92441681
182GATA1_19941826_ChIP-Seq_K562_Human0.92366847
183PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92259515
184NCOR1_26117541_ChIP-Seq_K562_Human0.90776210
185DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89695276
186FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88693289
187UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87184548
188BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86598761
189KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84293718
190RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84002510
191ELK4_26923725_Chip-Seq_MESODERM_Mouse0.83854794
192MITF_21258399_ChIP-Seq_MELANOMA_Human0.83736922
193TP53_23651856_ChIP-Seq_MEFs_Mouse0.83126605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.97661879
2MP0009780_abnormal_chondrocyte_physiolo3.40385062
3MP0004858_abnormal_nervous_system3.39710781
4MP0000569_abnormal_digit_pigmentation3.37148683
5MP0003787_abnormal_imprinting3.21080308
6MP0003705_abnormal_hypodermis_morpholog3.16127024
7MP0003635_abnormal_synaptic_transmissio2.75584659
8MP0004270_analgesia2.74242608
9MP0008877_abnormal_DNA_methylation2.70637321
10MP0003329_amyloid_beta_deposits2.66009279
11MP0010234_abnormal_vibrissa_follicle2.26852255
12MP0003303_peritoneal_inflammation2.26067261
13MP0010352_gastrointestinal_tract_polyps2.25131293
14MP0002063_abnormal_learning/memory/cond2.19178880
15MP0002272_abnormal_nervous_system2.18339105
16MP0006276_abnormal_autonomic_nervous2.16935602
17MP0001486_abnormal_startle_reflex2.14151481
18MP0001188_hyperpigmentation2.13526650
19MP0001529_abnormal_vocalization2.13264223
20MP0005076_abnormal_cell_differentiation2.12674316
21MP0004811_abnormal_neuron_physiology2.11956816
22MP0003121_genomic_imprinting2.05855327
23MP0005423_abnormal_somatic_nervous2.04750222
24MP0008961_abnormal_basal_metabolism2.04260981
25MP0003283_abnormal_digestive_organ2.04088002
26MP0004510_myositis1.99642636
27MP0001984_abnormal_olfaction1.90693923
28MP0000604_amyloidosis1.90370647
29MP0002837_dystrophic_cardiac_calcinosis1.87540394
30MP0003172_abnormal_lysosome_physiology1.87086512
31MP0003122_maternal_imprinting1.85951185
32MP0010307_abnormal_tumor_latency1.82990004
33MP0001348_abnormal_lacrimal_gland1.78452426
34MP0002089_abnormal_postnatal_growth/wei1.75686907
35MP0002909_abnormal_adrenal_gland1.74853212
36MP0005623_abnormal_meninges_morphology1.73142443
37MP0001968_abnormal_touch/_nociception1.61824661
38MP0002733_abnormal_thermal_nociception1.58338191
39MP0002067_abnormal_sensory_capabilities1.57531127
40MP0005360_urolithiasis1.54874461
41MP0004142_abnormal_muscle_tone1.54817344
42MP0002735_abnormal_chemical_nociception1.50021326
43MP0003123_paternal_imprinting1.49139645
44MP0009745_abnormal_behavioral_response1.49047968
45MP0004130_abnormal_muscle_cell1.45997027
46MP0002557_abnormal_social/conspecific_i1.45685885
47MP0002822_catalepsy1.45087790
48MP0002734_abnormal_mechanical_nocicepti1.42276510
49MP0002102_abnormal_ear_morphology1.41114375
50MP0003300_gastrointestinal_ulcer1.39801835
51MP0002064_seizures1.36879474
52MP0000631_abnormal_neuroendocrine_gland1.35110597
53MP0000955_abnormal_spinal_cord1.33283776
54MP0005551_abnormal_eye_electrophysiolog1.30588612
55MP0002877_abnormal_melanocyte_morpholog1.30547780
56MP0004742_abnormal_vestibular_system1.29897366
57MP0006072_abnormal_retinal_apoptosis1.29621150
58MP0002751_abnormal_autonomic_nervous1.29460467
59MP0002638_abnormal_pupillary_reflex1.29176310
60MP0004133_heterotaxia1.28660380
61MP0009046_muscle_twitch1.26770747
62MP0005394_taste/olfaction_phenotype1.26429236
63MP0005499_abnormal_olfactory_system1.26429236
64MP0001730_embryonic_growth_arrest1.24710546
65MP0003075_altered_response_to1.24139584
66MP0001177_atelectasis1.21844046
67MP0005410_abnormal_fertilization1.12384920
68MP0001485_abnormal_pinna_reflex1.12306081
69MP0002752_abnormal_somatic_nervous1.12113819
70MP0006292_abnormal_olfactory_placode1.11797564
71MP0004215_abnormal_myocardial_fiber1.08371404
72MP0010329_abnormal_lipoprotein_level1.07726714
73MP0005085_abnormal_gallbladder_physiolo1.07294653
74MP0000778_abnormal_nervous_system1.07261004
75MP0003252_abnormal_bile_duct1.07117947
76MP0005187_abnormal_penis_morphology1.06531204
77MP0002139_abnormal_hepatobiliary_system1.05702449
78MP0003136_yellow_coat_color1.04534926
79MP0003111_abnormal_nucleus_morphology1.03551355
80MP0009278_abnormal_bone_marrow1.02812989
81MP0002572_abnormal_emotion/affect_behav1.01022247
82MP0005167_abnormal_blood-brain_barrier1.00571195
83MP0003221_abnormal_cardiomyocyte_apopto0.99963787
84MP0003937_abnormal_limbs/digits/tail_de0.99578733
85MP0005365_abnormal_bile_salt0.99354437
86MP0003633_abnormal_nervous_system0.98441138
87MP0008569_lethality_at_weaning0.96288701
88MP0002269_muscular_atrophy0.95950755
89MP0002152_abnormal_brain_morphology0.95251004
90MP0005646_abnormal_pituitary_gland0.95124208
91MP0008770_decreased_survivor_rate0.93384557
92MP0002184_abnormal_innervation0.92850166
93MP0001293_anophthalmia0.92558985
94MP0003941_abnormal_skin_development0.92511786
95MP0005253_abnormal_eye_physiology0.92454609
96MP0004233_abnormal_muscle_weight0.92437087
97MP0008789_abnormal_olfactory_epithelium0.92144461
98MP0002736_abnormal_nociception_after0.92058643
99MP0003137_abnormal_impulse_conducting0.91116133
100MP0001501_abnormal_sleep_pattern0.89100399
101MP0000537_abnormal_urethra_morphology0.89012585
102MP0000013_abnormal_adipose_tissue0.88687769
103MP0003566_abnormal_cell_adhesion0.88511821
104MP0001905_abnormal_dopamine_level0.88231115
105MP0001545_abnormal_hematopoietic_system0.88043164
106MP0005397_hematopoietic_system_phenotyp0.88043164
107MP0003567_abnormal_fetal_cardiomyocyte0.87948868
108MP0002229_neurodegeneration0.87742525
109MP0001849_ear_inflammation0.87651704
110MP0003632_abnormal_nervous_system0.87604987
111MP0002084_abnormal_developmental_patter0.87543828
112MP0003091_abnormal_cell_migration0.87128019
113MP0004924_abnormal_behavior0.86077771
114MP0005386_behavior/neurological_phenoty0.86077771
115MP0009672_abnormal_birth_weight0.85499427
116MP0009840_abnormal_foam_cell0.84998680
117MP0003631_nervous_system_phenotype0.84728822
118MP0002938_white_spotting0.84669405
119MP0001970_abnormal_pain_threshold0.83455124
120MP0003879_abnormal_hair_cell0.81132516
121MP0004197_abnormal_fetal_growth/weight/0.80204941
122MP0002086_abnormal_extraembryonic_tissu0.79925687
123MP0003115_abnormal_respiratory_system0.79812516
124MP0008057_abnormal_DNA_replication0.78116561
125MP0004085_abnormal_heartbeat0.77989628
126MP0005195_abnormal_posterior_eye0.77941653
127MP0003880_abnormal_central_pattern0.77745122
128MP0002396_abnormal_hematopoietic_system0.77650688
129MP0002066_abnormal_motor_capabilities/c0.77094505
130MP0002069_abnormal_eating/drinking_beha0.76464590
131MP0002080_prenatal_lethality0.75882640
132MP0003119_abnormal_digestive_system0.75513295
133MP0000350_abnormal_cell_proliferation0.75239361
134MP0001440_abnormal_grooming_behavior0.74443277
135MP0003890_abnormal_embryonic-extraembry0.73891169
136MP0001958_emphysema0.73877299
137MP0002653_abnormal_ependyma_morphology0.73663995
138MP0001299_abnormal_eye_distance/0.73394898
139MP0002090_abnormal_vision0.73112785
140MP0002233_abnormal_nose_morphology0.72845499
141MP0002081_perinatal_lethality0.72776954
142MP0003861_abnormal_nervous_system0.72686258
143MP0004808_abnormal_hematopoietic_stem0.72514457
144MP0004145_abnormal_muscle_electrophysio0.72230082
145MP0001963_abnormal_hearing_physiology0.70593272
146MP0004885_abnormal_endolymph0.70535073
147MP0003656_abnormal_erythrocyte_physiolo0.70167002
148MP0002882_abnormal_neuron_morphology0.69979079
149MP0000003_abnormal_adipose_tissue0.68869436
150MP0005645_abnormal_hypothalamus_physiol0.68569460
151MP0008874_decreased_physiological_sensi0.68554275
152MP0001697_abnormal_embryo_size0.68508690
153MP0003646_muscle_fatigue0.67756404
154MP0000026_abnormal_inner_ear0.67088127
155MP0003755_abnormal_palate_morphology0.66150744
156MP0001915_intracranial_hemorrhage0.66122550
157MP0000049_abnormal_middle_ear0.65107596
158MP0000566_synostosis0.64047472
159MP0010770_preweaning_lethality0.63209950
160MP0002082_postnatal_lethality0.63209950
161MP0001986_abnormal_taste_sensitivity0.62640967

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)4.35189700
2Focal motor seizures (HP:0011153)4.33618614
3Amyotrophic lateral sclerosis (HP:0007354)4.19835411
4Limb dystonia (HP:0002451)4.00011830
5Myokymia (HP:0002411)3.64256424
6Febrile seizures (HP:0002373)3.63327968
7Broad-based gait (HP:0002136)3.58130722
8Papilledema (HP:0001085)3.37091377
9Abnormality of the labia minora (HP:0012880)3.26842757
10Hyperventilation (HP:0002883)3.26440964
11Atonic seizures (HP:0010819)3.20927315
12Hyperacusis (HP:0010780)2.99236926
13Epileptic encephalopathy (HP:0200134)2.98210618
14Progressive cerebellar ataxia (HP:0002073)2.96809577
15Cortical dysplasia (HP:0002539)2.91933096
16Dialeptic seizures (HP:0011146)2.84996876
17Insomnia (HP:0100785)2.83599217
18Visual hallucinations (HP:0002367)2.81748833
19Pointed chin (HP:0000307)2.81098017
20Atrophy/Degeneration involving motor neurons (HP:0007373)2.79796421
21Hand muscle atrophy (HP:0009130)2.77777547
22Action tremor (HP:0002345)2.74789043
23Heterotopia (HP:0002282)2.74727561
24Upper limb amyotrophy (HP:0009129)2.69606588
25Distal upper limb amyotrophy (HP:0007149)2.69606588
26Gait imbalance (HP:0002141)2.68680276
27Hepatoblastoma (HP:0002884)2.65901792
28Apathy (HP:0000741)2.64152849
29Termporal pattern (HP:0011008)2.62180167
30Insidious onset (HP:0003587)2.62180167
31Supranuclear gaze palsy (HP:0000605)2.60449058
32Abnormality of the astrocytes (HP:0100707)2.55450422
33Astrocytoma (HP:0009592)2.55450422
34Dysmetric saccades (HP:0000641)2.55392562
35Colon cancer (HP:0003003)2.55207994
36Polyphagia (HP:0002591)2.55143353
37Septo-optic dysplasia (HP:0100842)2.54800223
38Volvulus (HP:0002580)2.53379987
39Urinary bladder sphincter dysfunction (HP:0002839)2.52084379
40Macroorchidism (HP:0000053)2.51967725
41Impaired vibration sensation in the lower limbs (HP:0002166)2.51341481
42Pancreatic cysts (HP:0001737)2.50747722
43Protruding tongue (HP:0010808)2.50640443
44Urinary urgency (HP:0000012)2.50538718
45Generalized tonic-clonic seizures (HP:0002069)2.50290024
46Diminished motivation (HP:0000745)2.48992233
47Medial flaring of the eyebrow (HP:0010747)2.48547324
48Inappropriate behavior (HP:0000719)2.48324439
49Peritonitis (HP:0002586)2.48272122
50Abnormality of the motor neurons (HP:0002450)2.46769413
51Abnormal neuron morphology (HP:0012757)2.46769413
52Inability to walk (HP:0002540)2.46217391
53Pancreatic fibrosis (HP:0100732)2.42921198
54Cerebral inclusion bodies (HP:0100314)2.40558659
55Progressive inability to walk (HP:0002505)2.40523710
56Genital tract atresia (HP:0001827)2.39263174
57Mutism (HP:0002300)2.38892809
58Subacute progressive viral hepatitis (HP:0006572)2.37884480
59Abnormal social behavior (HP:0012433)2.37049206
60Impaired social interactions (HP:0000735)2.37049206
61Absence seizures (HP:0002121)2.36861315
62Gaze-evoked nystagmus (HP:0000640)2.36518821
63Postural instability (HP:0002172)2.35858218
64Poor eye contact (HP:0000817)2.35464200
65Elfin facies (HP:0004428)2.35087688
66Vaginal atresia (HP:0000148)2.33613256
67Nephronophthisis (HP:0000090)2.30903825
68Focal seizures (HP:0007359)2.30661502
69Ankle clonus (HP:0011448)2.29847104
70Epileptiform EEG discharges (HP:0011182)2.28897043
71Renovascular hypertension (HP:0100817)2.25515038
72Congenital primary aphakia (HP:0007707)2.25341504
73Molar tooth sign on MRI (HP:0002419)2.23427013
74Abnormality of midbrain morphology (HP:0002418)2.23427013
75Intellectual disability, profound (HP:0002187)2.23280987
76Optic nerve hypoplasia (HP:0000609)2.21806481
77Resting tremor (HP:0002322)2.21599332
78Lissencephaly (HP:0001339)2.21009032
79Abnormal hair whorl (HP:0010721)2.17615885
80EEG with generalized epileptiform discharges (HP:0011198)2.17556755
81Disinhibition (HP:0000734)2.17433431
82Annular pancreas (HP:0001734)2.16932838
83Impaired smooth pursuit (HP:0007772)2.16446071
84Bowel diverticulosis (HP:0005222)2.16239099
85Specific learning disability (HP:0001328)2.16095441
86Hypsarrhythmia (HP:0002521)2.15310891
87Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15124838
88Poor suck (HP:0002033)2.14587874
89Depression (HP:0000716)2.14430463
90Abnormality of ocular smooth pursuit (HP:0000617)2.13952582
91Nephrogenic diabetes insipidus (HP:0009806)2.11881497
92Intestinal atresia (HP:0011100)2.10983285
93Shallow orbits (HP:0000586)2.07350389
94Achilles tendon contracture (HP:0001771)2.07145408
95Abnormality of the Achilles tendon (HP:0005109)2.06547490
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05264958
97Increased nuchal translucency (HP:0010880)2.04013291
98Degeneration of the lateral corticospinal tracts (HP:0002314)2.03824695
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03824695
100Spastic tetraparesis (HP:0001285)2.03099002
101Torticollis (HP:0000473)2.03005624
102Pachygyria (HP:0001302)2.02282443
103Decreased muscle mass (HP:0003199)1.99212913
104Enlarged penis (HP:0000040)1.98282451
105True hermaphroditism (HP:0010459)1.97573955
106Ependymoma (HP:0002888)1.97214778
107Hemiplegia (HP:0002301)1.96742318
108Cerebral aneurysm (HP:0004944)1.96336009
109Abnormality of the corticospinal tract (HP:0002492)1.94454246
110Ankyloglossia (HP:0010296)1.93735776
111Abnormality of the renal medulla (HP:0100957)1.93366954
112Spastic tetraplegia (HP:0002510)1.92709693
113Deep venous thrombosis (HP:0002625)1.91815104
114Spastic diplegia (HP:0001264)1.91386776
115Agitation (HP:0000713)1.90092135
116Absent speech (HP:0001344)1.89435104
117Poor coordination (HP:0002370)1.87770832
118Hemiparesis (HP:0001269)1.87378267
119Exotropia (HP:0000577)1.84533456
120Genetic anticipation (HP:0003743)1.83756426
121Oligodactyly (hands) (HP:0001180)1.82412525
122Agnosia (HP:0010524)1.82390694
123Fibroma (HP:0010614)1.81505486
124Abnormality of the septum pellucidum (HP:0007375)1.80631897
125Clonus (HP:0002169)1.79186142
126Labial hypoplasia (HP:0000066)1.78168382
127Dyskinesia (HP:0100660)1.77854428
128Bradykinesia (HP:0002067)1.77492858
129Narrow forehead (HP:0000341)1.76335729
130Aqueductal stenosis (HP:0002410)1.75831367
131Elevated erythrocyte sedimentation rate (HP:0003565)1.75785108
132Overriding aorta (HP:0002623)1.75687060
133Growth hormone deficiency (HP:0000824)1.75180414
134Absent septum pellucidum (HP:0001331)1.74470916
135Chorioretinal atrophy (HP:0000533)1.74028681
136Megalencephaly (HP:0001355)1.73207713
137Pheochromocytoma (HP:0002666)1.73097580
138Tetraplegia (HP:0002445)1.72951428
139Focal dystonia (HP:0004373)1.72909330
140Renal duplication (HP:0000075)1.72879820
141Morphological abnormality of the pyramidal tract (HP:0002062)1.72546974
142Supernumerary spleens (HP:0009799)1.71388607
143Fibrous tissue neoplasm (HP:0012316)1.71336175
144Frequent falls (HP:0002359)1.70896827
145Abnormal eating behavior (HP:0100738)1.70273059
146Hypothermia (HP:0002045)1.69463039
147Hip dysplasia (HP:0001385)1.69403640
148Neurofibrillary tangles (HP:0002185)1.68781799
149Spastic gait (HP:0002064)1.68588705
150Craniofacial dystonia (HP:0012179)1.68454546
151Striae distensae (HP:0001065)1.67518710
152Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67483545
153Glioma (HP:0009733)1.67397241
154Genu recurvatum (HP:0002816)1.67330973
155Abnormality of salivation (HP:0100755)1.67163516
156Gastrointestinal infarctions (HP:0005244)1.67148154
157Turricephaly (HP:0000262)1.66997531
158Long toe (HP:0010511)1.66340965
159Impaired vibratory sensation (HP:0002495)1.65696778
160Amblyopia (HP:0000646)1.64972310
161Abnormality of the periventricular white matter (HP:0002518)1.64454048
162Intestinal polyposis (HP:0200008)1.64453927
163Amyloidosis (HP:0011034)1.63286571
164Fair hair (HP:0002286)1.61206130
165Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60842244
166Short 4th metacarpal (HP:0010044)1.60842244
167Neuronal loss in central nervous system (HP:0002529)1.60790579
168Drooling (HP:0002307)1.60727515
169Excessive salivation (HP:0003781)1.60727515
170Abnormality of oral frenula (HP:0000190)1.59883854
171Intestinal polyp (HP:0005266)1.59799112
172Pseudobulbar signs (HP:0002200)1.58940127
173Hyperinsulinemic hypoglycemia (HP:0000825)1.58938241
174Chronic hepatic failure (HP:0100626)1.58615240
175Neoplasm of the oral cavity (HP:0100649)1.58285405
176Esotropia (HP:0000565)1.58107337
177Long foot (HP:0001833)1.57181926
178Medulloblastoma (HP:0002885)1.56950910
179Dysdiadochokinesis (HP:0002075)1.56526161
180Absent eyebrow (HP:0002223)1.56474959

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.13405133
2CASK4.03572241
3MARK13.80627946
4TRIB33.08675616
5PKN23.02612113
6TNIK2.96788828
7SCYL22.93349657
8EEF2K2.82480149
9WNK32.70973679
10KSR22.44627351
11CAMKK12.39288292
12FRK2.34418434
13MINK12.30230987
14MKNK22.29661444
15INSRR2.26663580
16PRKD32.23757858
17MAP3K102.11835013
18LATS22.03722690
19MAP2K72.02008238
20PINK12.01718750
21BMPR1B2.01096005
22NEK11.96751418
23PAK61.89904703
24ALK1.87816842
25NTRK31.86883560
26RIPK11.74938206
27BCR1.73891529
28MAPK131.70271128
29KSR11.67676724
30DYRK21.65959370
31NTRK11.65010617
32DAPK21.63895534
33TESK11.55062305
34TSSK61.54712965
35ACVR1B1.53953083
36TRIM281.52166336
37TAOK11.48132995
38ICK1.42668958
39PDK31.42084645
40PDK41.42084645
41MAP3K41.41695282
42RET1.41550021
43CDK121.36279600
44TESK21.35780900
45MKNK11.33175728
46TYRO31.31839362
47PLK21.28750247
48CSNK1G11.24901316
49BUB11.23663808
50PDGFRA1.21499069
51CDK191.18333372
52ERBB31.17449893
53NTRK21.10835388
54STK38L1.10587513
55CSNK1G31.10280920
56MAP2K41.08915440
57MAP3K21.02291632
58DAPK11.00481712
59CSNK1A1L0.98784360
60SGK20.96885257
61PTK60.96372886
62RPS6KA20.96059554
63STK380.95887144
64CDK150.94416995
65DYRK1A0.94065251
66UHMK10.93910194
67NUAK10.91967632
68CDK180.91066907
69STK390.89667666
70CDK50.89440359
71OXSR10.89314153
72SIK20.88842515
73SGK4940.86090120
74SGK2230.86090120
75CAMK1G0.85260771
76ZAK0.84682842
77CDK140.83801677
78ADRBK20.83449497
79PDK10.83420115
80CAMK2A0.83387119
81TGFBR10.82732817
82BRSK10.82369136
83ERN10.82235529
84CDK11A0.81965045
85STK110.80441846
86PRKCE0.79966786
87PLK30.79402228
88PRKCH0.76541396
89LATS10.75734709
90MTOR0.75666970
91LRRK20.75248031
92BRD40.75080888
93MAP3K80.74755856
94RAF10.74714611
95LMTK20.74313918
96FGFR20.74267979
97OBSCN0.73105772
98DYRK30.72318473
99NEK20.70459729
100CAMKK20.69477711
101FLT30.67327147
102CDC70.67326249
103BMX0.66187843
104FGFR30.65066494
105PNCK0.64799813
106EPHA40.63977274
107WNK10.61791186
108FGFR10.60633227
109PKN10.59808766
110AKT30.59388092
111TAF10.59246315
112PAK30.58995681
113SIK10.57489283
114CAMK2B0.56416565
115PDPK10.56055336
116PTK20.55569791
117GRK10.54478230
118PHKG20.53456541
119PHKG10.53456541
120MAP3K120.52893723
121PAK40.51466128
122PLK40.51338948
123TTN0.50991709
124CDK40.50630695
125WNK40.50206337
126CSF1R0.49455332
127CSNK1E0.49351232
128PRKCZ0.48819800
129MAP2K10.46754223
130MAP4K20.45858174
131SRPK10.45182590
132SGK30.43918798
133EPHB20.43274241
134CAMK10.42890910
135JAK20.42538229
136TIE10.40947904
137FGFR40.40871357
138CSNK1G20.40006239
139PAK20.39401368
140SGK10.39073528
141PRKCG0.38959988
142CDK30.38474418
143CAMK2D0.37724901
144PRKG10.37680225
145ARAF0.37676192
146MAP3K50.37624426
147GRK60.35864406
148CSNK1A10.35430084
149TTK0.35389032
150PDGFRB0.35368945
151CDK60.35125345
152PRKDC0.34992413
153PLK10.34645457
154CAMK1D0.34064195
155NLK0.34063796
156PRKACA0.33842844
157FYN0.33317816
158MARK20.32935240
159RPS6KA30.32328742
160RPS6KB10.31482642
161MAPK100.30233522
162CDK20.29635217
163JAK10.29501778
164CHEK10.29345917
165CSNK1D0.28768534
166RPS6KA10.28501645

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.60419670
2Phototransduction_Homo sapiens_hsa047442.15741940
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14608478
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84027131
5Synaptic vesicle cycle_Homo sapiens_hsa047211.80322792
6Taste transduction_Homo sapiens_hsa047421.78331215
7Steroid biosynthesis_Homo sapiens_hsa001001.77447066
8Long-term potentiation_Homo sapiens_hsa047201.77429415
9Oocyte meiosis_Homo sapiens_hsa041141.68084032
10Protein export_Homo sapiens_hsa030601.65417530
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58287027
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56788289
13Cardiac muscle contraction_Homo sapiens_hsa042601.50974678
14Olfactory transduction_Homo sapiens_hsa047401.50323570
15mTOR signaling pathway_Homo sapiens_hsa041501.49862258
16Glioma_Homo sapiens_hsa052141.47980923
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44032318
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42271424
19Basal transcription factors_Homo sapiens_hsa030221.40806386
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40345872
21Serotonergic synapse_Homo sapiens_hsa047261.39869385
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39414026
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37518035
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.36789647
25Type II diabetes mellitus_Homo sapiens_hsa049301.35686639
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31543481
27Dopaminergic synapse_Homo sapiens_hsa047281.31498378
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.31389199
29Estrogen signaling pathway_Homo sapiens_hsa049151.28817491
30Arginine biosynthesis_Homo sapiens_hsa002201.28208532
31Circadian entrainment_Homo sapiens_hsa047131.27811198
32Endometrial cancer_Homo sapiens_hsa052131.27376205
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26286329
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25467262
35Bile secretion_Homo sapiens_hsa049761.21825581
36RNA degradation_Homo sapiens_hsa030181.21161204
37Selenocompound metabolism_Homo sapiens_hsa004501.20414237
38Dorso-ventral axis formation_Homo sapiens_hsa043201.18081126
39Non-small cell lung cancer_Homo sapiens_hsa052231.17277893
40Gastric acid secretion_Homo sapiens_hsa049711.16058959
41VEGF signaling pathway_Homo sapiens_hsa043701.14298983
42Gap junction_Homo sapiens_hsa045401.13248731
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12638894
44Oxidative phosphorylation_Homo sapiens_hsa001901.11968969
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11309831
46Parkinsons disease_Homo sapiens_hsa050121.11058633
47Calcium signaling pathway_Homo sapiens_hsa040201.10690832
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10337851
49Glutamatergic synapse_Homo sapiens_hsa047241.10177510
50Cholinergic synapse_Homo sapiens_hsa047251.09982688
51Circadian rhythm_Homo sapiens_hsa047101.08671098
52Collecting duct acid secretion_Homo sapiens_hsa049661.08611949
53Chronic myeloid leukemia_Homo sapiens_hsa052201.08324672
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08304432
55GABAergic synapse_Homo sapiens_hsa047271.07447574
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05029727
57Butanoate metabolism_Homo sapiens_hsa006501.04401655
58Insulin signaling pathway_Homo sapiens_hsa049101.03915637
59Glucagon signaling pathway_Homo sapiens_hsa049221.02859456
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01766372
61Salivary secretion_Homo sapiens_hsa049701.00842022
62Amphetamine addiction_Homo sapiens_hsa050311.00254976
63Oxytocin signaling pathway_Homo sapiens_hsa049210.99342723
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.98336295
65Colorectal cancer_Homo sapiens_hsa052100.96961989
66Propanoate metabolism_Homo sapiens_hsa006400.95569974
67GnRH signaling pathway_Homo sapiens_hsa049120.94581817
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93949913
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93505749
70Wnt signaling pathway_Homo sapiens_hsa043100.92695565
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92013048
72Hippo signaling pathway_Homo sapiens_hsa043900.91869561
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91756987
74Viral myocarditis_Homo sapiens_hsa054160.91563177
75Insulin secretion_Homo sapiens_hsa049110.91254862
76ErbB signaling pathway_Homo sapiens_hsa040120.87893221
77Fatty acid biosynthesis_Homo sapiens_hsa000610.87261534
78Alzheimers disease_Homo sapiens_hsa050100.86868064
79Morphine addiction_Homo sapiens_hsa050320.86824188
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86035413
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85392683
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84113566
83Biosynthesis of amino acids_Homo sapiens_hsa012300.82880145
84Insulin resistance_Homo sapiens_hsa049310.82671260
85Ether lipid metabolism_Homo sapiens_hsa005650.82663650
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.81931691
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81926109
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81020278
89AMPK signaling pathway_Homo sapiens_hsa041520.79962042
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79514110
91Prion diseases_Homo sapiens_hsa050200.78851015
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77991124
93Endocytosis_Homo sapiens_hsa041440.76952945
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.75567805
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75072179
96Regulation of autophagy_Homo sapiens_hsa041400.74286793
97Non-homologous end-joining_Homo sapiens_hsa034500.73660644
98Dilated cardiomyopathy_Homo sapiens_hsa054140.73595962
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71396427
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69380034
101Renin secretion_Homo sapiens_hsa049240.67726908
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67505373
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67455194
104Hedgehog signaling pathway_Homo sapiens_hsa043400.66886840
105Ras signaling pathway_Homo sapiens_hsa040140.64819766
106Nicotine addiction_Homo sapiens_hsa050330.63579094
107mRNA surveillance pathway_Homo sapiens_hsa030150.62650541
108Cocaine addiction_Homo sapiens_hsa050300.62572890
109Proteoglycans in cancer_Homo sapiens_hsa052050.61988637
110MAPK signaling pathway_Homo sapiens_hsa040100.61664235
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61572737
112Pancreatic cancer_Homo sapiens_hsa052120.60652201
113Huntingtons disease_Homo sapiens_hsa050160.60166440
114Axon guidance_Homo sapiens_hsa043600.59716637
115Tight junction_Homo sapiens_hsa045300.59626270
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58928346
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58860103
118Melanogenesis_Homo sapiens_hsa049160.58669576
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58589068
120Platelet activation_Homo sapiens_hsa046110.57891143
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56783180
122Rap1 signaling pathway_Homo sapiens_hsa040150.55738032
123Renal cell carcinoma_Homo sapiens_hsa052110.55679410
124Prolactin signaling pathway_Homo sapiens_hsa049170.55538953
125Focal adhesion_Homo sapiens_hsa045100.55285419
126Carbon metabolism_Homo sapiens_hsa012000.55071413
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54857363
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54051107
129Bladder cancer_Homo sapiens_hsa052190.53270987
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53248761
131cAMP signaling pathway_Homo sapiens_hsa040240.52166899
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51765814
133TGF-beta signaling pathway_Homo sapiens_hsa043500.51631200
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51453047
135Alcoholism_Homo sapiens_hsa050340.50499291
136Shigellosis_Homo sapiens_hsa051310.49972717
137RNA polymerase_Homo sapiens_hsa030200.49528937
138Notch signaling pathway_Homo sapiens_hsa043300.49417934
139Long-term depression_Homo sapiens_hsa047300.48276065
140Melanoma_Homo sapiens_hsa052180.48138071
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47876251
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.47734082
143B cell receptor signaling pathway_Homo sapiens_hsa046620.47674824
144Thyroid hormone synthesis_Homo sapiens_hsa049180.47341273
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47094245
146Amoebiasis_Homo sapiens_hsa051460.46095089
147Lysine degradation_Homo sapiens_hsa003100.46042788
148Ovarian steroidogenesis_Homo sapiens_hsa049130.45939819
149Fanconi anemia pathway_Homo sapiens_hsa034600.45614848
150Basal cell carcinoma_Homo sapiens_hsa052170.44869723
151Vitamin B6 metabolism_Homo sapiens_hsa007500.41524050
152RNA transport_Homo sapiens_hsa030130.40955093

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