ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cornea development in camera-type eye (GO:0061303)	3.45364486
2	retinal cone cell development (GO:0046549)	3.45081590
3	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.32862343
4	protein heterotrimerization (GO:0070208)	3.30487152
5	keratan sulfate catabolic process (GO:0042340)	3.28298172
6	positive regulation of protein kinase C signaling (GO:0090037)	3.21743246
7	glomerular basement membrane development (GO:0032836)	3.16434440
8	arginine catabolic process (GO:0006527)	3.16266655
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.12610991
10	lymphangiogenesis (GO:0001946)	3.05259353
11	regulation of hippo signaling (GO:0035330)	3.05249679
12	response to nitrosative stress (GO:0051409)	3.00956721
13	nephron epithelium morphogenesis (GO:0072088)	3.00784230
14	nephron tubule morphogenesis (GO:0072078)	3.00784230
15	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.96702684
16	organ induction (GO:0001759)	2.93148272
17	regulation of gene silencing by RNA (GO:0060966)	2.91923502
18	regulation of posttranscriptional gene silencing (GO:0060147)	2.91923502
19	regulation of gene silencing by miRNA (GO:0060964)	2.91923502
20	paraxial mesoderm development (GO:0048339)	2.88050430
21	embryonic skeletal joint morphogenesis (GO:0060272)	2.87690080
22	kidney morphogenesis (GO:0060993)	2.82638661
23	epithelial cilium movement (GO:0003351)	2.78827913
24	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.76047773
25	renal tubule morphogenesis (GO:0061333)	2.71509217
26	glycerophospholipid catabolic process (GO:0046475)	2.70882259
27	cell proliferation in forebrain (GO:0021846)	2.69719641
28	inner ear receptor stereocilium organization (GO:0060122)	2.67716588
29	negative regulation of Rho protein signal transduction (GO:0035024)	2.65424085
30	dorsal/ventral axis specification (GO:0009950)	2.64918835
31	blood vessel maturation (GO:0001955)	2.64249937
32	L-phenylalanine catabolic process (GO:0006559)	2.64230012
33	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.64230012
34	water-soluble vitamin biosynthetic process (GO:0042364)	2.63785336
35	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.63057437
36	tyrosine metabolic process (GO:0006570)	2.60175269
37	axoneme assembly (GO:0035082)	2.60101298
38	negative regulation of axon guidance (GO:1902668)	2.57286697
39	bone trabecula formation (GO:0060346)	2.57208221
40	negative regulation of gluconeogenesis (GO:0045721)	2.57030776
41	regulation of hexokinase activity (GO:1903299)	2.55543900
42	regulation of glucokinase activity (GO:0033131)	2.55543900
43	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.55050277
44	developmental induction (GO:0031128)	2.55015968
45	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.53313263
46	heparin metabolic process (GO:0030202)	2.51106339
47	heparin biosynthetic process (GO:0030210)	2.51106339
48	cell-cell signaling involved in cell fate commitment (GO:0045168)	2.50209622
49	axon extension involved in axon guidance (GO:0048846)	2.50056341
50	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.50056341
51	nonmotile primary cilium assembly (GO:0035058)	2.48706321
52	limb development (GO:0060173)	2.48333746
53	appendage development (GO:0048736)	2.48333746
54	secondary metabolite biosynthetic process (GO:0044550)	2.48291014
55	arginine metabolic process (GO:0006525)	2.45393059
56	negative regulation of autophagy (GO:0010507)	2.44451374
57	head development (GO:0060322)	2.44331033
58	artery development (GO:0060840)	2.44155313
59	DNA double-strand break processing (GO:0000729)	2.43676770
60	melanocyte differentiation (GO:0030318)	2.42630011
61	dermatan sulfate metabolic process (GO:0030205)	2.41657642
62	endothelial cell proliferation (GO:0001935)	2.40091807
63	pigment cell differentiation (GO:0050931)	2.39965004
64	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.39675216
65	cilium morphogenesis (GO:0060271)	2.38933369
66	neuroepithelial cell differentiation (GO:0060563)	2.38107828
67	auditory receptor cell stereocilium organization (GO:0060088)	2.37020601
68	virion attachment to host cell (GO:0019062)	2.36458784
69	adhesion of symbiont to host cell (GO:0044650)	2.36458784
70	glutathione derivative biosynthetic process (GO:1901687)	2.36122715
71	glutathione derivative metabolic process (GO:1901685)	2.36122715
72	glomerular filtration (GO:0003094)	2.35523094
73	C4-dicarboxylate transport (GO:0015740)	2.35151078
74	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.34931990
75	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.34931990
76	regulation of translation, ncRNA-mediated (GO:0045974)	2.34931990
77	cilium movement (GO:0003341)	2.34619436
78	positive regulation of chondrocyte differentiation (GO:0032332)	2.31936401
79	neuron maturation (GO:0042551)	2.30838351
80	neuron remodeling (GO:0016322)	2.28291481
81	intraciliary transport (GO:0042073)	2.28165407
82	presynaptic membrane assembly (GO:0097105)	2.26804946
83	regulation of endothelial cell differentiation (GO:0045601)	2.24848022
84	chondrocyte proliferation (GO:0035988)	2.24444032
85	phagocytosis, recognition (GO:0006910)	2.23501301
86	positive regulation of glycogen biosynthetic process (GO:0045725)	2.22689194
87	regulation of integrin-mediated signaling pathway (GO:2001044)	2.22555433
88	regulation of organ formation (GO:0003156)	2.21883801
89	negative regulation of leukocyte chemotaxis (GO:0002689)	2.20747077
90	retina vasculature morphogenesis in camera-type eye (GO:0061299)	2.19449582
91	cilium or flagellum-dependent cell motility (GO:0001539)	2.19205320
92	tooth mineralization (GO:0034505)	2.18499741
93	vascular endothelial growth factor signaling pathway (GO:0038084)	2.17593356
94	dermatan sulfate biosynthetic process (GO:0030208)	2.15055627
95	postsynaptic membrane organization (GO:0001941)	2.14667106
96	endothelium development (GO:0003158)	2.14347836
97	positive regulation of glycolytic process (GO:0045821)	2.13947590
98	positive regulation of neuroblast proliferation (GO:0002052)	2.13179545
99	positive regulation of cartilage development (GO:0061036)	2.13108257
100	cell migration involved in heart development (GO:0060973)	2.12508402

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.65814341
2	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.52714479
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.34003575
4	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.31585420
5	ZNF274_21170338_ChIP-Seq_K562_Hela	1.99075273
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.93366459
7	EZH2_22144423_ChIP-Seq_EOC_Human	1.91233035
8	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.83129764
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.77113036
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.73424393
11	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.72712669
12	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.68675922
13	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.66002788
14	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.61045602
15	DROSHA_22980978_ChIP-Seq_HELA_Human	1.60502573
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.58105789
17	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.54377287
18	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.53955484
19	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.52675278
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.51690485
21	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.49883782
22	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.49497959
23	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.48649528
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.47886704
25	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.47597860
26	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.46150063
27	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.46150063
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42102432
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.41852807
30	P300_19829295_ChIP-Seq_ESCs_Human	1.41278185
31	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40058754
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.39828166
33	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.39176876
34	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38460706
35	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.38205123
36	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.37696290
37	CTCF_27219007_Chip-Seq_Bcells_Human	1.37322509
38	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.37117066
39	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.35739457
40	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.35720199
41	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.35121819
42	CJUN_26792858_Chip-Seq_BT549_Human	1.35079782
43	AR_25329375_ChIP-Seq_VCAP_Human	1.32025074
44	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.29374804
45	EWS_26573619_Chip-Seq_HEK293_Human	1.29223104
46	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.28864037
47	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.26942090
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24891070
49	VDR_22108803_ChIP-Seq_LS180_Human	1.22886181
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20530936
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19256317
52	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.19235389
53	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.18968889
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18330652
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.18144689
56	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.16269882
57	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.15107995
58	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.14652893
59	STAT3_23295773_ChIP-Seq_U87_Human	1.14295625
60	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.13438151
61	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.12944723
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.12730331
63	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.12174981
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12093037
65	FUS_26573619_Chip-Seq_HEK293_Human	1.11987739
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10639254
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10045619
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.09817942
69	TCF4_23295773_ChIP-Seq_U87_Human	1.08322002
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07872582
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07789164
72	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.07698922
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07223155
74	MYC_19829295_ChIP-Seq_ESCs_Human	1.06919919
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06886863
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06644019
77	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06644019
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06212533
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05668663
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05617296
81	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.04198420
82	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.03615962
83	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.02964271
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.02555843
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02296999
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00810427
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99328645
88	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.99167951
89	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.99161916
90	TBL1_22424771_ChIP-Seq_293T_Human	0.98616426
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.98517730
92	TP53_22573176_ChIP-Seq_HFKS_Human	0.98149400
93	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.96398554
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95113481
95	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.94800083
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.94186363
97	AHR_22903824_ChIP-Seq_MCF-7_Human	0.93864592
98	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.93511421
99	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93440691
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93069702

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.18121628
2	MP0005503_abnormal_tendon_morphology	3.89940052
3	MP0002837_dystrophic_cardiac_calcinosis	3.40009533
4	MP0005171_absent_coat_pigmentation	3.28705810
5	MP0002938_white_spotting	2.84365141
6	MP0008438_abnormal_cutaneous_collagen	2.73077178
7	MP0003279_aneurysm	2.59443696
8	MP0006292_abnormal_olfactory_placode	2.54602724
9	MP0010030_abnormal_orbit_morphology	2.52148870
10	MP0006054_spinal_hemorrhage	2.30920311
11	MP0005174_abnormal_tail_pigmentation	2.28326304
12	MP0010368_abnormal_lymphatic_system	2.22447503
13	MP0002653_abnormal_ependyma_morphology	2.17694990
14	MP0005670_abnormal_white_adipose	2.04595049
15	MP0003122_maternal_imprinting	2.01856764
16	MP0000013_abnormal_adipose_tissue	1.99789231
17	MP0009384_cardiac_valve_regurgitation	1.85396830
18	MP0004272_abnormal_basement_membrane	1.84299378
19	MP0004147_increased_porphyrin_level	1.80815511
20	MP0001958_emphysema	1.75059426
21	MP0005167_abnormal_blood-brain_barrier	1.73982288
22	MP0000372_irregular_coat_pigmentation	1.70227046
23	MP0002295_abnormal_pulmonary_circulatio	1.69132611
24	MP0005408_hypopigmentation	1.67023768
25	MP0005275_abnormal_skin_tensile	1.65454131
26	MP0004133_heterotaxia	1.62472807
27	MP0002108_abnormal_muscle_morphology	1.60432972
28	MP0006072_abnormal_retinal_apoptosis	1.57320546
29	MP0000751_myopathy	1.50692138
30	MP0000049_abnormal_middle_ear	1.45943308
31	MP0005551_abnormal_eye_electrophysiolog	1.42270466
32	MP0004885_abnormal_endolymph	1.39509320
33	MP0005508_abnormal_skeleton_morphology	1.38329069
34	MP0002909_abnormal_adrenal_gland	1.37434316
35	MP0003011_delayed_dark_adaptation	1.34390461
36	MP0001299_abnormal_eye_distance/	1.30796255
37	MP0005379_endocrine/exocrine_gland_phen	1.29303472
38	MP0005253_abnormal_eye_physiology	1.26099775
39	MP0000767_abnormal_smooth_muscle	1.24269188
40	MP0003878_abnormal_ear_physiology	1.23637715
41	MP0005377_hearing/vestibular/ear_phenot	1.23637715
42	MP0004043_abnormal_pH_regulation	1.21116369
43	MP0001188_hyperpigmentation	1.19449095
44	MP0002933_joint_inflammation	1.18508993
45	MP0000015_abnormal_ear_pigmentation	1.18371686
46	MP0003646_muscle_fatigue	1.16836342
47	MP0005257_abnormal_intraocular_pressure	1.16041849
48	MP0005075_abnormal_melanosome_morpholog	1.14211101
49	MP0004084_abnormal_cardiac_muscle	1.12735420
50	MP0003283_abnormal_digestive_organ	1.08184135
51	MP0005248_abnormal_Harderian_gland	1.04248037
52	MP0005595_abnormal_vascular_smooth	1.03735066
53	MP0008775_abnormal_heart_ventricle	1.02841026
54	MP0001986_abnormal_taste_sensitivity	1.02687345
55	MP0001879_abnormal_lymphatic_vessel	1.01221604
56	MP0003186_abnormal_redox_activity	1.00946549
57	MP0009250_abnormal_appendicular_skeleto	0.99686498
58	MP0002115_abnormal_skeleton_extremities	0.98294740
59	MP0000631_abnormal_neuroendocrine_gland	0.97455351
60	MP0004215_abnormal_myocardial_fiber	0.96277317
61	MP0002095_abnormal_skin_pigmentation	0.94768965
62	MP0009780_abnormal_chondrocyte_physiolo	0.94073311
63	MP0000026_abnormal_inner_ear	0.91789987
64	MP0001293_anophthalmia	0.90027477
65	MP0003195_calcinosis	0.88909095
66	MP0000163_abnormal_cartilage_morphology	0.88065603
67	MP0002075_abnormal_coat/hair_pigmentati	0.88028136
68	MP0000569_abnormal_digit_pigmentation	0.86390014
69	MP0002160_abnormal_reproductive_system	0.86205793
70	MP0002090_abnormal_vision	0.86021889
71	MP0002932_abnormal_joint_morphology	0.84897115
72	MP0003137_abnormal_impulse_conducting	0.84437917
73	MP0008875_abnormal_xenobiotic_pharmacok	0.83559387
74	MP0000371_diluted_coat_color	0.82479726
75	MP0002254_reproductive_system_inflammat	0.81678943
76	MP0000427_abnormal_hair_cycle	0.80557312
77	MP0009379_abnormal_foot_pigmentation	0.79860785
78	MP0000778_abnormal_nervous_system	0.79581534
79	MP0000230_abnormal_systemic_arterial	0.78824817
80	MP0002138_abnormal_hepatobiliary_system	0.78457503
81	MP0000566_synostosis	0.78297990
82	MP0002127_abnormal_cardiovascular_syste	0.76775731
83	MP0002697_abnormal_eye_size	0.76505715
84	MP0004085_abnormal_heartbeat	0.75887513
85	MP0003942_abnormal_urinary_system	0.75488542
86	MP0005391_vision/eye_phenotype	0.75118090
87	MP0005195_abnormal_posterior_eye	0.73789340
88	MP0002116_abnormal_craniofacial_bone	0.73750897
89	MP0001756_abnormal_urination	0.73454992
90	MP0003755_abnormal_palate_morphology	0.73333671
91	MP0001324_abnormal_eye_pigmentation	0.72895930
92	MP0001270_distended_abdomen	0.72523263
93	MP0002233_abnormal_nose_morphology	0.71263389
94	MP0002557_abnormal_social/conspecific_i	0.67405346
95	MP0001963_abnormal_hearing_physiology	0.66630826
96	MP0002109_abnormal_limb_morphology	0.66369991
97	MP0002896_abnormal_bone_mineralization	0.66214563
98	MP0006138_congestive_heart_failure	0.66179833
99	MP0003119_abnormal_digestive_system	0.65787214
100	MP0004019_abnormal_vitamin_homeostasis	0.64981291

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	3.65881727
2	Pancreatic cysts (HP:0001737)	3.51199937
3	Broad metatarsal (HP:0001783)	3.40133858
4	True hermaphroditism (HP:0010459)	3.38607131
5	Tubular atrophy (HP:0000092)	3.33953177
6	Nephronophthisis (HP:0000090)	3.06215181
7	Cystic liver disease (HP:0006706)	2.93120100
8	White forelock (HP:0002211)	2.88961721
9	Protrusio acetabuli (HP:0003179)	2.80902665
10	Enlarged penis (HP:0000040)	2.78043094
11	Intestinal atresia (HP:0011100)	2.77711237
12	Cervical subluxation (HP:0003308)	2.77474862
13	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.77089403
14	Molar tooth sign on MRI (HP:0002419)	2.76102205
15	Abnormality of midbrain morphology (HP:0002418)	2.76102205
16	Occipital encephalocele (HP:0002085)	2.74068668
17	Wrist flexion contracture (HP:0001239)	2.67513247
18	Abnormality of the renal medulla (HP:0100957)	2.65059163
19	Chronic hepatic failure (HP:0100626)	2.53792844
20	Hematochezia (HP:0002573)	2.52142520
21	Hypoplasia of the fovea (HP:0007750)	2.44186851
22	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.44186851
23	Patchy hypopigmentation of hair (HP:0011365)	2.36711386
24	Congenital hepatic fibrosis (HP:0002612)	2.33806233
25	Mesangial abnormality (HP:0001966)	2.33803989
26	Ectopic kidney (HP:0000086)	2.33294789
27	Pendular nystagmus (HP:0012043)	2.32260369
28	Soft skin (HP:0000977)	2.32190295
29	Rib fusion (HP:0000902)	2.30340442
30	Septo-optic dysplasia (HP:0100842)	2.25832296
31	Vitreoretinal degeneration (HP:0000655)	2.24552516
32	Coronal craniosynostosis (HP:0004440)	2.24198690
33	High pitched voice (HP:0001620)	2.23421939
34	Severe Myopia (HP:0011003)	2.22816280
35	Bladder diverticulum (HP:0000015)	2.20909247
36	Medial flaring of the eyebrow (HP:0010747)	2.20581667
37	Infantile muscular hypotonia (HP:0008947)	2.18419448
38	Congenital sensorineural hearing impairment (HP:0008527)	2.16157738
39	Joint stiffness (HP:0001387)	2.14771613
40	Hyperinsulinemic hypoglycemia (HP:0000825)	2.13071033
41	Premature rupture of membranes (HP:0001788)	2.09096085
42	Abnormality of the fovea (HP:0000493)	2.08977029
43	Congenital stationary night blindness (HP:0007642)	2.05320450
44	Bulbous nose (HP:0000414)	2.04902880
45	Stage 5 chronic kidney disease (HP:0003774)	1.99968928
46	Postaxial foot polydactyly (HP:0001830)	1.97062996
47	Aortic valve stenosis (HP:0001650)	1.96911322
48	J-shaped sella turcica (HP:0002680)	1.96085830
49	Ketoacidosis (HP:0001993)	1.92741346
50	Preaxial foot polydactyly (HP:0001841)	1.92096352
51	Abnormal biliary tract physiology (HP:0012439)	1.90707131
52	Bile duct proliferation (HP:0001408)	1.90707131
53	Nephrogenic diabetes insipidus (HP:0009806)	1.88921887
54	Lymphangioma (HP:0100764)	1.88237735
55	Abnormality of the vertebral endplates (HP:0005106)	1.88208721
56	Patent foramen ovale (HP:0001655)	1.87056902
57	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.87015445
58	Aortic aneurysm (HP:0004942)	1.85681782
59	Type II lissencephaly (HP:0007260)	1.84539517
60	Anophthalmia (HP:0000528)	1.82954795
61	Abnormality of the aortic arch (HP:0012303)	1.81543119
62	Enlarged kidneys (HP:0000105)	1.81099605
63	Bony spicule pigmentary retinopathy (HP:0007737)	1.80796353
64	Abnormality of the anterior chamber (HP:0000593)	1.79332160
65	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78923547
66	Abnormal respiratory epithelium morphology (HP:0012253)	1.78923547
67	Short hallux (HP:0010109)	1.78917918
68	Limited hip movement (HP:0008800)	1.78407598
69	Depressed nasal tip (HP:0000437)	1.77325802
70	Morphological abnormality of the middle ear (HP:0008609)	1.76886897
71	Congenital primary aphakia (HP:0007707)	1.74924018
72	Abnormality of the diencephalon (HP:0010662)	1.74088942
73	Pulmonary artery stenosis (HP:0004415)	1.73762877
74	Abnormality of dentin (HP:0010299)	1.71973070
75	Abnormal drinking behavior (HP:0030082)	1.71280907
76	Polydipsia (HP:0001959)	1.71280907
77	Irregular vertebral endplates (HP:0003301)	1.71150447
78	Tachypnea (HP:0002789)	1.71131042
79	Aortic regurgitation (HP:0001659)	1.70919765
80	Gait imbalance (HP:0002141)	1.70874900
81	Delayed CNS myelination (HP:0002188)	1.68873143
82	Asplenia (HP:0001746)	1.68645509
83	Slender long bone (HP:0003100)	1.68454488
84	Microglossia (HP:0000171)	1.67720100
85	Hip contracture (HP:0003273)	1.66647798
86	Hyperventilation (HP:0002883)	1.65884522
87	Mildly elevated creatine phosphokinase (HP:0008180)	1.65162742
88	Neonatal short-limb short stature (HP:0008921)	1.65143762
89	Absent septum pellucidum (HP:0001331)	1.63687905
90	Hypoplastic ischia (HP:0003175)	1.63163170
91	Shallow orbits (HP:0000586)	1.62025817
92	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.61954129
93	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.61266890
94	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.60592598
95	Anencephaly (HP:0002323)	1.60069376
96	Aplasia/Hypoplasia of the macula (HP:0008059)	1.59548891
97	Type 1 muscle fiber predominance (HP:0003803)	1.59228849
98	Dandy-Walker malformation (HP:0001305)	1.59107108
99	Median cleft lip (HP:0000161)	1.58578957
100	Round ear (HP:0100830)	1.58298460

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.68208753
2	MUSK	4.49923269
3	FRK	4.01509499
4	INSRR	3.52103309
5	BMPR1B	3.13467964
6	EPHB2	2.49620643
7	GRK1	2.29978490
8	MYLK	1.99972679
9	FGFR2	1.96436244
10	MAP4K2	1.94991795
11	WNK3	1.94346818
12	ADRBK2	1.92539727
13	KIT	1.62052810
14	MAPK15	1.61515243
15	DDR2	1.55429377
16	PINK1	1.38295529
17	NUAK1	1.34086792
18	FER	1.33883558
19	ZAK	1.30979498
20	TGFBR1	1.27447367
21	MAP3K7	1.21810219
22	ACVR1B	1.21802642
23	PHKG2	1.21565425
24	PHKG1	1.21565425
25	MAPK7	1.20850525
26	CASK	1.18817043
27	TNIK	1.14313821
28	PAK3	1.13556219
29	NTRK3	1.11434121
30	STK16	1.09503674
31	DAPK2	1.08277850
32	PTK2B	1.08086129
33	PRKCE	1.05638915
34	WEE1	1.04770837
35	MATK	1.04236768
36	MAP3K4	1.00687346
37	MET	0.97997503
38	PDGFRA	0.97538570
39	BRSK2	0.96782260
40	IRAK1	0.96056661
41	HIPK2	0.95730878
42	WNK4	0.94210517
43	PRKD2	0.92231472
44	DYRK2	0.92040985
45	TGFBR2	0.90552202
46	DYRK3	0.89296419
47	ADRBK1	0.86881020
48	PTK2	0.84436336
49	MAP2K6	0.82770881
50	ERBB2	0.81826931
51	PDK2	0.81815218
52	NLK	0.81330778
53	MAP2K7	0.81127914
54	GSK3A	0.78508642
55	CAMK1	0.77800675
56	PRKD1	0.76515933
57	TNK2	0.76509928
58	PRKAA2	0.76356627
59	BMX	0.74700520
60	PASK	0.74430008
61	NME1	0.69628568
62	CSNK1G1	0.69618215
63	CDC42BPA	0.69253178
64	MKNK2	0.67212016
65	PRKAA1	0.67108803
66	STK11	0.65648048
67	NTRK1	0.65540197
68	PKN1	0.62939949
69	STK3	0.60206039
70	FLT3	0.59691221
71	PRKCG	0.56535571
72	GRK5	0.54331662
73	RPS6KA2	0.52353598
74	PIK3CA	0.52267692
75	PKN2	0.52080541
76	EPHA3	0.51937427
77	PRKCI	0.50338247
78	PTK6	0.50034921
79	PLK2	0.47270389
80	PNCK	0.46910258
81	CSNK1G3	0.45653185
82	MAP3K6	0.44140600
83	MARK3	0.40919251
84	CHUK	0.40903364
85	RPS6KA6	0.39797406
86	PRKACA	0.39742485
87	TLK1	0.38630968
88	PRKG2	0.38320404
89	KDR	0.38316011
90	STK38L	0.38029638
91	MARK1	0.37298199
92	RIPK1	0.36452271
93	ROCK1	0.36407551
94	LMTK2	0.35650852
95	MKNK1	0.35116924
96	AKT3	0.34694815
97	PAK4	0.34475450
98	MAPK13	0.33564340
99	FGFR1	0.33195898
100	VRK2	0.32931385

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.64674667
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.51230532
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.49233542
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.25311328
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.25126761
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.24978429
7	Butanoate metabolism_Homo sapiens_hsa00650	2.24217522
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.14193831
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02950830
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.99721642
11	Basal cell carcinoma_Homo sapiens_hsa05217	1.78175191
12	ECM-receptor interaction_Homo sapiens_hsa04512	1.74514606
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.63624852
14	Fatty acid elongation_Homo sapiens_hsa00062	1.53804726
15	ABC transporters_Homo sapiens_hsa02010	1.52037485
16	Protein digestion and absorption_Homo sapiens_hsa04974	1.51595278
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.49089859
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46214375
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45257111
20	Insulin secretion_Homo sapiens_hsa04911	1.44526122
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.42813484
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.42746460
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.42235372
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.39316484
25	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.36147666
26	Glutathione metabolism_Homo sapiens_hsa00480	1.34824386
27	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.33954733
28	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.29729268
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.28889540
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.27564323
31	Fatty acid degradation_Homo sapiens_hsa00071	1.25725278
32	Protein export_Homo sapiens_hsa03060	1.24358107
33	Lysine degradation_Homo sapiens_hsa00310	1.22315594
34	Other glycan degradation_Homo sapiens_hsa00511	1.22152383
35	Phototransduction_Homo sapiens_hsa04744	1.21789243
36	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.20490366
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20339601
38	Fat digestion and absorption_Homo sapiens_hsa04975	1.18521095
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.11160249
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.10329786
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02842570
42	Axon guidance_Homo sapiens_hsa04360	0.99780546
43	Histidine metabolism_Homo sapiens_hsa00340	0.97854034
44	Sulfur relay system_Homo sapiens_hsa04122	0.97505566
45	Notch signaling pathway_Homo sapiens_hsa04330	0.94811067
46	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.93711600
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92973105
48	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91564748
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.91551778
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89868246
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89204177
52	Parkinsons disease_Homo sapiens_hsa05012	0.88457399
53	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.88212197
54	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.87860089
55	Huntingtons disease_Homo sapiens_hsa05016	0.87847896
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.86747501
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.86658159
58	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.85206967
59	Melanogenesis_Homo sapiens_hsa04916	0.84386259
60	Mineral absorption_Homo sapiens_hsa04978	0.83298255
61	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.83217432
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.80900320
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79473168
64	Tyrosine metabolism_Homo sapiens_hsa00350	0.79293775
65	Olfactory transduction_Homo sapiens_hsa04740	0.79276826
66	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.79096822
67	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.75840226
68	Cocaine addiction_Homo sapiens_hsa05030	0.73777947
69	Complement and coagulation cascades_Homo sapiens_hsa04610	0.72560612
70	Retinol metabolism_Homo sapiens_hsa00830	0.71334533
71	Alzheimers disease_Homo sapiens_hsa05010	0.70329607
72	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.69823270
73	Homologous recombination_Homo sapiens_hsa03440	0.69810886
74	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.69379011
75	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.69205370
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.65818301
77	Hippo signaling pathway_Homo sapiens_hsa04390	0.65452294
78	Morphine addiction_Homo sapiens_hsa05032	0.65407088
79	Lysosome_Homo sapiens_hsa04142	0.65340379
80	Propanoate metabolism_Homo sapiens_hsa00640	0.65259129
81	Basal transcription factors_Homo sapiens_hsa03022	0.63499135
82	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.63358681
83	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.63252296
84	Folate biosynthesis_Homo sapiens_hsa00790	0.62920528
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.62266419
86	Taste transduction_Homo sapiens_hsa04742	0.61844438
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.61494875
88	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.60691615
89	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.60303412
90	Renin secretion_Homo sapiens_hsa04924	0.60283158
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58787222
92	Bile secretion_Homo sapiens_hsa04976	0.58670226
93	Metabolic pathways_Homo sapiens_hsa01100	0.57252244
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.56804395
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56413404
96	RNA polymerase_Homo sapiens_hsa03020	0.56082014
97	Pancreatic secretion_Homo sapiens_hsa04972	0.55568333
98	Serotonergic synapse_Homo sapiens_hsa04726	0.55297682
99	Peroxisome_Homo sapiens_hsa04146	0.54993425
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.54476225

MTMR9LP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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