ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.53951984
2	L-fucose catabolic process (GO:0042355)	4.30238555
3	fucose catabolic process (GO:0019317)	4.30238555
4	L-fucose metabolic process (GO:0042354)	4.30238555
5	response to pheromone (GO:0019236)	3.97921921
6	protein complex biogenesis (GO:0070271)	3.89503400
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.87121998
8	cellular ketone body metabolic process (GO:0046950)	3.84993117
9	respiratory chain complex IV assembly (GO:0008535)	3.65901216
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.62686623
11	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.60634107
12	piRNA metabolic process (GO:0034587)	3.60441944
13	epithelial cilium movement (GO:0003351)	3.55140529
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.54317200
15	NADH dehydrogenase complex assembly (GO:0010257)	3.54317200
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.54317200
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.52104789
18	protein-cofactor linkage (GO:0018065)	3.51533388
19	tryptophan catabolic process (GO:0006569)	3.44006533
20	indole-containing compound catabolic process (GO:0042436)	3.44006533
21	indolalkylamine catabolic process (GO:0046218)	3.44006533
22	ketone body metabolic process (GO:1902224)	3.42975239
23	cytochrome complex assembly (GO:0017004)	3.42135345
24	DNA deamination (GO:0045006)	3.35808117
25	axoneme assembly (GO:0035082)	3.34689533
26	negative regulation of telomere maintenance (GO:0032205)	3.33654831
27	neural tube formation (GO:0001841)	3.33091213
28	DNA methylation involved in gamete generation (GO:0043046)	3.30437900
29	indolalkylamine metabolic process (GO:0006586)	3.25357173
30	regulation of cilium movement (GO:0003352)	3.23175453
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.19100709
32	DNA double-strand break processing (GO:0000729)	3.18873611
33	platelet dense granule organization (GO:0060155)	3.17205781
34	kynurenine metabolic process (GO:0070189)	3.11131619
35	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.09300744
36	cilium morphogenesis (GO:0060271)	3.06083921
37	kidney morphogenesis (GO:0060993)	3.05375470
38	gamma-aminobutyric acid transport (GO:0015812)	3.01136661
39	cornea development in camera-type eye (GO:0061303)	3.00529353
40	nonmotile primary cilium assembly (GO:0035058)	2.99806176
41	tryptophan metabolic process (GO:0006568)	2.94027781
42	protein neddylation (GO:0045116)	2.92033587
43	cilium movement (GO:0003341)	2.91040775
44	behavioral response to ethanol (GO:0048149)	2.88548287
45	rRNA catabolic process (GO:0016075)	2.84255356
46	protein polyglutamylation (GO:0018095)	2.84056776
47	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.82084594
48	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.81467971
49	inositol phosphate catabolic process (GO:0071545)	2.77778015
50	adaptation of signaling pathway (GO:0023058)	2.75242655
51	detection of light stimulus involved in visual perception (GO:0050908)	2.75096872
52	detection of light stimulus involved in sensory perception (GO:0050962)	2.75096872
53	retinal cone cell development (GO:0046549)	2.72595818
54	cilium organization (GO:0044782)	2.71775881
55	cellular biogenic amine catabolic process (GO:0042402)	2.70892852
56	amine catabolic process (GO:0009310)	2.70892852
57	inositol phosphate dephosphorylation (GO:0046855)	2.69711565
58	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.69711565
59	mannosylation (GO:0097502)	2.67538880
60	protein K11-linked deubiquitination (GO:0035871)	2.65224085
61	rhodopsin mediated signaling pathway (GO:0016056)	2.64430456
62	cilium assembly (GO:0042384)	2.64023679
63	preassembly of GPI anchor in ER membrane (GO:0016254)	2.63039833
64	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.62342553
65	ATP synthesis coupled proton transport (GO:0015986)	2.62342553
66	negative regulation of mast cell activation (GO:0033004)	2.61764672
67	photoreceptor cell development (GO:0042461)	2.57368017
68	regulation of neurotransmitter uptake (GO:0051580)	2.56921099
69	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.56326425
70	somite development (GO:0061053)	2.51440076
71	indole-containing compound metabolic process (GO:0042430)	2.49444952
72	sulfation (GO:0051923)	2.48751087
73	pyrimidine nucleobase catabolic process (GO:0006208)	2.48746253
74	regulation of action potential (GO:0098900)	2.48623275
75	embryonic epithelial tube formation (GO:0001838)	2.48376484
76	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.47872578
77	electron transport chain (GO:0022900)	2.46387197
78	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.45818215
79	male meiosis I (GO:0007141)	2.45326609
80	polyol catabolic process (GO:0046174)	2.44777579
81	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.43049806
82	proline transport (GO:0015824)	2.42861485
83	regulation of microtubule-based movement (GO:0060632)	2.40997379
84	dendritic spine morphogenesis (GO:0060997)	2.40720585
85	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.40623383
86	negative regulation of heart rate (GO:0010459)	2.40033623
87	nucleobase catabolic process (GO:0046113)	2.39568742
88	auditory receptor cell stereocilium organization (GO:0060088)	2.38789088
89	dopamine transport (GO:0015872)	2.38372643
90	photoreceptor cell maintenance (GO:0045494)	2.37537300
91	intraciliary transport (GO:0042073)	2.37217991
92	respiratory electron transport chain (GO:0022904)	2.36548052
93	synaptic transmission, cholinergic (GO:0007271)	2.35291537
94	peptidyl-histidine modification (GO:0018202)	2.34716747
95	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.34702793
96	organelle membrane fusion (GO:0090174)	2.34083047
97	serotonin receptor signaling pathway (GO:0007210)	2.33976031
98	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.33482007
99	neuronal action potential (GO:0019228)	2.33123689
100	multicellular organism reproduction (GO:0032504)	2.32755342

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.01472459
2	VDR_22108803_ChIP-Seq_LS180_Human	3.75604207
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.69413463
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63104860
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.52046510
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.39436548
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37135210
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.33107656
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.29699500
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.29323625
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.28178180
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.19835744
13	FUS_26573619_Chip-Seq_HEK293_Human	2.13197932
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07757084
15	P300_19829295_ChIP-Seq_ESCs_Human	2.02094019
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00206922
17	EWS_26573619_Chip-Seq_HEK293_Human	1.96556305
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92450542
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.88702564
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.79072786
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76671956
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.76455795
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.73694979
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.68683596
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.68377331
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.67742197
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.67171995
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.66352696
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.62130248
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52061374
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.51646648
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49815549
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.49815549
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47696664
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46867826
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46639682
37	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46014154
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.44465795
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43647184
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43565531
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43427394
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43169690
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42242958
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41429764
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40644898
46	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.40175861
47	AR_25329375_ChIP-Seq_VCAP_Human	1.39667351
48	STAT3_23295773_ChIP-Seq_U87_Human	1.39414869
49	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.37380651
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.36441578
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.36417995
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36288684
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36123882
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.34412432
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33936412
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33936412
57	TCF4_23295773_ChIP-Seq_U87_Human	1.32124900
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31289838
59	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30722221
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29725235
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29725235
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29687799
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28363442
64	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.27245236
65	AR_20517297_ChIP-Seq_VCAP_Human	1.26528950
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25933416
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25203886
68	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23619092
69	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23619092
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22249617
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21932905
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21181089
73	NCOR_22424771_ChIP-Seq_293T_Human	1.19946887
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18907970
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17803178
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16718130
77	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15348116
78	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14900247
79	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13916588
80	VDR_23849224_ChIP-Seq_CD4+_Human	1.13731768
81	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12065909
82	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11427421
83	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11067771
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10761783
85	AR_21572438_ChIP-Seq_LNCaP_Human	1.09192798
86	CDX2_22108803_ChIP-Seq_LS180_Human	1.09152776
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08660081
88	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.08232626
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07535140
90	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07509961
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07397450
92	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06354475
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05225719
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04873409
95	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02830378
96	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01762458
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01356373
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98544587
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96286130
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.96006031

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	3.22885302
2	MP0000372_irregular_coat_pigmentation	2.73007343
3	MP0000569_abnormal_digit_pigmentation	2.64871059
4	MP0003195_calcinosis	2.62002388
5	MP0005551_abnormal_eye_electrophysiolog	2.45002374
6	MP0005646_abnormal_pituitary_gland	2.39139973
7	MP0008877_abnormal_DNA_methylation	2.39096642
8	MP0001968_abnormal_touch/_nociception	2.36772053
9	MP0003136_yellow_coat_color	2.28079131
10	MP0005645_abnormal_hypothalamus_physiol	2.21215908
11	MP0002638_abnormal_pupillary_reflex	2.19199792
12	MP0006072_abnormal_retinal_apoptosis	2.18989024
13	MP0001984_abnormal_olfaction	2.06499806
14	MP0008872_abnormal_physiological_respon	1.98972464
15	MP0002102_abnormal_ear_morphology	1.96016078
16	MP0005084_abnormal_gallbladder_morpholo	1.94178481
17	MP0003787_abnormal_imprinting	1.92871429
18	MP0006292_abnormal_olfactory_placode	1.91943768
19	MP0005174_abnormal_tail_pigmentation	1.91739045
20	MP0002163_abnormal_gland_morphology	1.86739540
21	MP0005253_abnormal_eye_physiology	1.86080539
22	MP0002876_abnormal_thyroid_physiology	1.81027544
23	MP0002736_abnormal_nociception_after	1.80164941
24	MP0008875_abnormal_xenobiotic_pharmacok	1.79635960
25	MP0009745_abnormal_behavioral_response	1.75708095
26	MP0004142_abnormal_muscle_tone	1.73967926
27	MP0000631_abnormal_neuroendocrine_gland	1.71174436
28	MP0002653_abnormal_ependyma_morphology	1.70550533
29	MP0009046_muscle_twitch	1.70112026
30	MP0004885_abnormal_endolymph	1.69800150
31	MP0002938_white_spotting	1.68619515
32	MP0002272_abnormal_nervous_system	1.65428390
33	MP0002928_abnormal_bile_duct	1.62719350
34	MP0001986_abnormal_taste_sensitivity	1.61361558
35	MP0004043_abnormal_pH_regulation	1.59756175
36	MP0002234_abnormal_pharynx_morphology	1.58426265
37	MP0004147_increased_porphyrin_level	1.58319134
38	MP0003011_delayed_dark_adaptation	1.55090546
39	MP0003646_muscle_fatigue	1.53646731
40	MP0000427_abnormal_hair_cycle	1.53384633
41	MP0003880_abnormal_central_pattern	1.52356729
42	MP0001485_abnormal_pinna_reflex	1.50543932
43	MP0006276_abnormal_autonomic_nervous	1.48626523
44	MP0005379_endocrine/exocrine_gland_phen	1.46830214
45	MP0004133_heterotaxia	1.43548893
46	MP0001501_abnormal_sleep_pattern	1.41802758
47	MP0010386_abnormal_urinary_bladder	1.31294014
48	MP0005167_abnormal_blood-brain_barrier	1.24581272
49	MP0002095_abnormal_skin_pigmentation	1.20436239
50	MP0002064_seizures	1.19944615
51	MP0001970_abnormal_pain_threshold	1.19209763
52	MP0002572_abnormal_emotion/affect_behav	1.16217479
53	MP0001486_abnormal_startle_reflex	1.14744291
54	MP0005377_hearing/vestibular/ear_phenot	1.13670188
55	MP0003878_abnormal_ear_physiology	1.13670188
56	MP0002733_abnormal_thermal_nociception	1.13109325
57	MP0002909_abnormal_adrenal_gland	1.12230631
58	MP0001905_abnormal_dopamine_level	1.10884971
59	MP0002557_abnormal_social/conspecific_i	1.10405525
60	MP0003252_abnormal_bile_duct	1.10228674
61	MP0001529_abnormal_vocalization	1.07595933
62	MP0005367_renal/urinary_system_phenotyp	1.06949369
63	MP0000516_abnormal_urinary_system	1.06949369
64	MP0005195_abnormal_posterior_eye	1.05406395
65	MP0008789_abnormal_olfactory_epithelium	1.03673405
66	MP0002735_abnormal_chemical_nociception	1.02574724
67	MP0005389_reproductive_system_phenotype	1.02124980
68	MP0003121_genomic_imprinting	0.99837187
69	MP0003718_maternal_effect	0.97331453
70	MP0008995_early_reproductive_senescence	0.96641093
71	MP0004924_abnormal_behavior	0.96567392
72	MP0005386_behavior/neurological_phenoty	0.96567392
73	MP0004215_abnormal_myocardial_fiber	0.93973818
74	MP0000778_abnormal_nervous_system	0.93162234
75	MP0002160_abnormal_reproductive_system	0.92122310
76	MP0000230_abnormal_systemic_arterial	0.90807889
77	MP0002751_abnormal_autonomic_nervous	0.89736352
78	MP0002067_abnormal_sensory_capabilities	0.89480635
79	MP0005075_abnormal_melanosome_morpholog	0.89168629
80	MP0003806_abnormal_nucleotide_metabolis	0.89153403
81	MP0001944_abnormal_pancreas_morphology	0.88908013
82	MP0002734_abnormal_mechanical_nocicepti	0.87568879
83	MP0008775_abnormal_heart_ventricle	0.86731825
84	MP0004145_abnormal_muscle_electrophysio	0.86628652
85	MP0002693_abnormal_pancreas_physiology	0.86263748
86	MP0001324_abnormal_eye_pigmentation	0.85949438
87	MP0005187_abnormal_penis_morphology	0.85449005
88	MP0002138_abnormal_hepatobiliary_system	0.84587212
89	MP0004742_abnormal_vestibular_system	0.84143857
90	MP0001756_abnormal_urination	0.84046139
91	MP0002752_abnormal_somatic_nervous	0.83337669
92	MP0005410_abnormal_fertilization	0.82365819
93	MP0003635_abnormal_synaptic_transmissio	0.82357102
94	MP0000015_abnormal_ear_pigmentation	0.82156843
95	MP0002063_abnormal_learning/memory/cond	0.81790603
96	MP0001502_abnormal_circadian_rhythm	0.80549455
97	MP0001764_abnormal_homeostasis	0.80146929
98	MP0003122_maternal_imprinting	0.79748227
99	MP0001919_abnormal_reproductive_system	0.79364620
100	MP0005391_vision/eye_phenotype	0.76527749

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.30175924
2	Molar tooth sign on MRI (HP:0002419)	4.29190399
3	Abnormality of midbrain morphology (HP:0002418)	4.29190399
4	Pancreatic fibrosis (HP:0100732)	3.89393626
5	True hermaphroditism (HP:0010459)	3.86886546
6	Nephronophthisis (HP:0000090)	3.70534112
7	Type II lissencephaly (HP:0007260)	3.59023417
8	Congenital stationary night blindness (HP:0007642)	3.55703010
9	Acute necrotizing encephalopathy (HP:0006965)	3.22011145
10	Abnormality of the renal medulla (HP:0100957)	3.17702949
11	Medial flaring of the eyebrow (HP:0010747)	3.17390752
12	Mitochondrial inheritance (HP:0001427)	3.12771713
13	Progressive macrocephaly (HP:0004481)	3.08115676
14	Increased CSF lactate (HP:0002490)	2.94903293
15	Chronic hepatic failure (HP:0100626)	2.90053929
16	Abnormality of the renal cortex (HP:0011035)	2.88156516
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.79449251
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.77716202
19	Cystic liver disease (HP:0006706)	2.76201874
20	Tubular atrophy (HP:0000092)	2.74638565
21	Acute encephalopathy (HP:0006846)	2.73777814
22	Attenuation of retinal blood vessels (HP:0007843)	2.68398695
23	Cerebellar dysplasia (HP:0007033)	2.63663046
24	Hepatocellular necrosis (HP:0001404)	2.62270500
25	Hyperventilation (HP:0002883)	2.61150604
26	Abolished electroretinogram (ERG) (HP:0000550)	2.56123902
27	Gait imbalance (HP:0002141)	2.54921023
28	Hepatic necrosis (HP:0002605)	2.50147623
29	Increased hepatocellular lipid droplets (HP:0006565)	2.45975973
30	Keratoconus (HP:0000563)	2.45730747
31	Increased corneal curvature (HP:0100692)	2.45730747
32	Sclerocornea (HP:0000647)	2.44629327
33	Lipid accumulation in hepatocytes (HP:0006561)	2.42538380
34	Pendular nystagmus (HP:0012043)	2.41143207
35	Congenital primary aphakia (HP:0007707)	2.39773223
36	Hypothermia (HP:0002045)	2.37560951
37	Lissencephaly (HP:0001339)	2.32008715
38	Abnormal drinking behavior (HP:0030082)	2.28621812
39	Polydipsia (HP:0001959)	2.28621812
40	Optic disc pallor (HP:0000543)	2.25016324
41	Nephrogenic diabetes insipidus (HP:0009806)	2.22455667
42	Furrowed tongue (HP:0000221)	2.21585076
43	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.21140459
44	Large for gestational age (HP:0001520)	2.20099607
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16513398
46	Gaze-evoked nystagmus (HP:0000640)	2.14745313
47	Optic nerve hypoplasia (HP:0000609)	2.14232641
48	Congenital, generalized hypertrichosis (HP:0004540)	2.13703393
49	Anencephaly (HP:0002323)	2.10460067
50	3-Methylglutaconic aciduria (HP:0003535)	2.10028143
51	Stomatitis (HP:0010280)	2.08807177
52	Renal cortical cysts (HP:0000803)	2.07226674
53	Abnormality of alanine metabolism (HP:0010916)	2.06135203
54	Hyperalaninemia (HP:0003348)	2.06135203
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.06135203
56	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06071180
57	Congenital hepatic fibrosis (HP:0002612)	2.03706825
58	Vaginal atresia (HP:0000148)	2.02678922
59	Inability to walk (HP:0002540)	2.02136696
60	Male pseudohermaphroditism (HP:0000037)	2.00953087
61	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.00338859
62	Absent/shortened dynein arms (HP:0200106)	2.00338859
63	Hemiparesis (HP:0001269)	1.99204516
64	Genital tract atresia (HP:0001827)	1.99106017
65	Methylmalonic acidemia (HP:0002912)	1.98806102
66	Intestinal atresia (HP:0011100)	1.94994965
67	Renal Fanconi syndrome (HP:0001994)	1.93966473
68	Severe muscular hypotonia (HP:0006829)	1.93568461
69	Abnormal albumin level (HP:0012116)	1.93459940
70	Hypoalbuminemia (HP:0003073)	1.93459940
71	Concave nail (HP:0001598)	1.93196642
72	Stomach cancer (HP:0012126)	1.87217984
73	Increased serum lactate (HP:0002151)	1.83877784
74	Hypomagnesemia (HP:0002917)	1.82240170
75	Exertional dyspnea (HP:0002875)	1.81715660
76	Abnormal biliary tract physiology (HP:0012439)	1.81049691
77	Bile duct proliferation (HP:0001408)	1.81049691
78	Pachygyria (HP:0001302)	1.80251345
79	Constricted visual fields (HP:0001133)	1.79986890
80	Retinal dysplasia (HP:0007973)	1.79716480
81	Cerebral edema (HP:0002181)	1.78920425
82	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.78657178
83	Broad-based gait (HP:0002136)	1.78305656
84	Abnormal respiratory epithelium morphology (HP:0012253)	1.77289517
85	Abnormal respiratory motile cilium morphology (HP:0005938)	1.77289517
86	Polyuria (HP:0000103)	1.77077727
87	Postaxial foot polydactyly (HP:0001830)	1.76477636
88	Abnormality of the pons (HP:0007361)	1.76380553
89	Bony spicule pigmentary retinopathy (HP:0007737)	1.75493890
90	Occipital encephalocele (HP:0002085)	1.75406423
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74989060
92	Septo-optic dysplasia (HP:0100842)	1.74282490
93	Hypoplasia of the pons (HP:0012110)	1.74034480
94	Decreased central vision (HP:0007663)	1.72828730
95	Methylmalonic aciduria (HP:0012120)	1.72518882
96	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72058282
97	Lactic acidosis (HP:0003128)	1.71493523
98	Neoplasm of the adrenal cortex (HP:0100641)	1.67777700
99	Poor coordination (HP:0002370)	1.67578166
100	Tongue fasciculations (HP:0001308)	1.67453903

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.83006091
2	MAP4K2	2.97718708
3	ZAK	2.96117862
4	TAOK3	2.80833671
5	WNK3	2.77933429
6	ADRBK2	2.76279827
7	NUAK1	2.47295137
8	BMPR1B	2.36639838
9	GRK1	2.30157213
10	TXK	2.28541085
11	PINK1	2.14248418
12	INSRR	2.14126705
13	CASK	2.13275121
14	WNK4	2.13274573
15	FGFR2	1.80323644
16	MAPK13	1.76670430
17	ACVR1B	1.71719541
18	STK39	1.71413154
19	TLK1	1.68128375
20	OXSR1	1.67639589
21	MAP3K4	1.55015284
22	BCKDK	1.28074478
23	TIE1	1.23602212
24	MARK1	1.20909744
25	PHKG2	1.16631841
26	PHKG1	1.16631841
27	MAP2K7	1.16071371
28	PNCK	1.12844228
29	CSNK1G2	1.12684275
30	DYRK2	1.11926335
31	TNIK	1.09356481
32	CSNK1G1	1.09202717
33	CAMKK2	1.06632668
34	CSNK1G3	1.06351327
35	MAPKAPK3	1.04357952
36	ERBB3	1.03374376
37	DAPK2	1.03312018
38	PAK3	1.02910386
39	PRKCG	1.02404365
40	ADRBK1	0.96898085
41	MUSK	0.95926754
42	PRKCE	0.95743499
43	MKNK2	0.95352460
44	NLK	0.91275561
45	MAP2K6	0.91132620
46	TRIM28	0.89748786
47	IRAK1	0.84192575
48	EPHA3	0.83048514
49	PLK2	0.81515066
50	CSNK1A1L	0.81192494
51	TNK2	0.78828122
52	TEC	0.75682753
53	PRKCQ	0.74667250
54	TGFBR1	0.72062914
55	STK16	0.69187985
56	PLK3	0.68605137
57	STK38L	0.66886762
58	MST4	0.62769284
59	ITK	0.62238489
60	MAP2K2	0.62084376
61	PRKD3	0.62046091
62	MKNK1	0.60609114
63	VRK1	0.60214736
64	VRK2	0.59811514
65	NME1	0.58869164
66	CAMK2A	0.58405080
67	KIT	0.57453454
68	TAF1	0.57064617
69	PTK2B	0.56846429
70	LIMK1	0.56716750
71	MAPKAPK5	0.56626426
72	RPS6KA5	0.56467106
73	FER	0.55397282
74	STK11	0.55033163
75	NTRK2	0.54664300
76	NTRK3	0.53579502
77	IKBKB	0.52709537
78	PIK3CA	0.51458466
79	MAPK15	0.51083010
80	STK3	0.49281911
81	PRKACA	0.48804144
82	CSNK1A1	0.47129461
83	PKN1	0.46336568
84	PRKCI	0.46327196
85	PRKCZ	0.46148480
86	GRK7	0.44229900
87	BRSK2	0.43492200
88	EPHA4	0.43119961
89	PRKCA	0.38053995
90	GRK5	0.36971860
91	CAMK1	0.36750920
92	PRKG1	0.35120102
93	MINK1	0.34577832
94	PRKCH	0.34295880
95	PASK	0.34037215
96	EIF2AK3	0.33293395
97	CSNK1D	0.32386451
98	SYK	0.32262048
99	CAMK2D	0.32018821
100	OBSCN	0.30788549

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.01669766
2	Phototransduction_Homo sapiens_hsa04744	2.72888449
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.65859703
4	Protein export_Homo sapiens_hsa03060	2.61322043
5	Parkinsons disease_Homo sapiens_hsa05012	2.36358858
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.32319645
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.24821459
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.24170715
9	Butanoate metabolism_Homo sapiens_hsa00650	2.22982923
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.14825910
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13843544
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.06023267
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.02314730
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.91433004
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84464691
16	Homologous recombination_Homo sapiens_hsa03440	1.80038655
17	RNA polymerase_Homo sapiens_hsa03020	1.75917131
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75588688
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.71261583
20	Caffeine metabolism_Homo sapiens_hsa00232	1.64838871
21	Nicotine addiction_Homo sapiens_hsa05033	1.62170863
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.60360537
23	Basal transcription factors_Homo sapiens_hsa03022	1.58283347
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.56696481
25	Huntingtons disease_Homo sapiens_hsa05016	1.54125791
26	Alzheimers disease_Homo sapiens_hsa05010	1.52540063
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.47729024
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47563875
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.41868870
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.41062092
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39611414
32	Regulation of autophagy_Homo sapiens_hsa04140	1.38611656
33	Propanoate metabolism_Homo sapiens_hsa00640	1.36198241
34	Peroxisome_Homo sapiens_hsa04146	1.33756251
35	Proteasome_Homo sapiens_hsa03050	1.28955599
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.21272567
37	ABC transporters_Homo sapiens_hsa02010	1.17936321
38	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.16039812
39	Morphine addiction_Homo sapiens_hsa05032	1.14950732
40	Olfactory transduction_Homo sapiens_hsa04740	1.13924315
41	One carbon pool by folate_Homo sapiens_hsa00670	1.11212608
42	Insulin secretion_Homo sapiens_hsa04911	1.08017110
43	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.04131753
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.03995407
45	Taste transduction_Homo sapiens_hsa04742	1.03477572
46	RNA degradation_Homo sapiens_hsa03018	1.03363457
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.01414444
48	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00921174
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99240387
50	Sulfur metabolism_Homo sapiens_hsa00920	0.97836163
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.96651478
52	GABAergic synapse_Homo sapiens_hsa04727	0.96331229
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92592839
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91443055
55	Retinol metabolism_Homo sapiens_hsa00830	0.90632740
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84527728
57	Purine metabolism_Homo sapiens_hsa00230	0.84396985
58	Serotonergic synapse_Homo sapiens_hsa04726	0.84084490
59	Circadian entrainment_Homo sapiens_hsa04713	0.82472281
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79205055
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.76826219
62	Asthma_Homo sapiens_hsa05310	0.74382021
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74160197
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.72568876
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.70225948
66	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69772447
67	Metabolic pathways_Homo sapiens_hsa01100	0.68574812
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66685050
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65993936
70	Sulfur relay system_Homo sapiens_hsa04122	0.65307160
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63452284
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.63250295
73	Folate biosynthesis_Homo sapiens_hsa00790	0.61746584
74	Salivary secretion_Homo sapiens_hsa04970	0.61245820
75	Primary immunodeficiency_Homo sapiens_hsa05340	0.59673177
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59411009
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.55390380
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55374387
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55294432
80	Fatty acid elongation_Homo sapiens_hsa00062	0.51733427
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51494001
82	Mineral absorption_Homo sapiens_hsa04978	0.50148757
83	Ribosome_Homo sapiens_hsa03010	0.48578917
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.48388080
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46900644
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.44317184
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42618009
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.41246333
89	Fatty acid degradation_Homo sapiens_hsa00071	0.40887282
90	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.37192261
91	Nucleotide excision repair_Homo sapiens_hsa03420	0.36832853
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36614094
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.35133273
94	Circadian rhythm_Homo sapiens_hsa04710	0.33872517
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.32062299
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.30298436
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28245376
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.28117573
99	Graft-versus-host disease_Homo sapiens_hsa05332	0.27872874
100	Histidine metabolism_Homo sapiens_hsa00340	0.27338445

MTND1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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