MTND1P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)5.23499365
2positive regulation of gamma-delta T cell activation (GO:0046645)4.96279105
3negative regulation of interleukin-1 beta production (GO:0032691)4.75845843
4detection of molecule of bacterial origin (GO:0032490)4.75562446
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.33603999
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.33603999
7modulation by symbiont of host immune response (GO:0052553)4.33603999
8positive regulation by symbiont of host defense response (GO:0052509)4.33603999
9modulation by symbiont of host defense response (GO:0052031)4.33603999
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.33603999
11regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.31299881
12response to peptidoglycan (GO:0032494)4.28442710
13positive regulation of growth hormone secretion (GO:0060124)4.27451894
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.17213306
15negative regulation of interleukin-1 production (GO:0032692)3.98384070
16microglial cell activation (GO:0001774)3.95061884
17regulation of gamma-delta T cell activation (GO:0046643)3.94958161
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.94779215
19interferon-gamma-mediated signaling pathway (GO:0060333)3.90541512
20cellular extravasation (GO:0045123)3.90198392
21growth hormone receptor signaling pathway (GO:0060396)3.90056126
22growth hormone secretion (GO:0030252)3.75961888
23detection of external biotic stimulus (GO:0098581)3.73314900
24detection of other organism (GO:0098543)3.68756896
25positive regulation of steroid hormone secretion (GO:2000833)3.63837000
26mannose metabolic process (GO:0006013)3.58204499
27interleukin-6-mediated signaling pathway (GO:0070102)3.56537735
28regulation of gamma-delta T cell differentiation (GO:0045586)3.55371246
29regulation of interleukin-6 biosynthetic process (GO:0045408)3.54961512
30macrophage activation involved in immune response (GO:0002281)3.46748547
31histone H3-K4 trimethylation (GO:0080182)3.45792901
32cellular response to growth hormone stimulus (GO:0071378)3.42506832
33nucleoside diphosphate catabolic process (GO:0009134)3.39375627
34regulation of interferon-beta biosynthetic process (GO:0045357)3.39235101
35positive regulation of interferon-alpha production (GO:0032727)3.37899651
36response to host immune response (GO:0052572)3.37387517
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37387517
38cellular response to ethanol (GO:0071361)3.35840468
39regulation of germinal center formation (GO:0002634)3.31002052
40detection of bacterium (GO:0016045)3.29699345
41neutrophil activation involved in immune response (GO:0002283)3.27834126
42adult feeding behavior (GO:0008343)3.27601428
43purinergic nucleotide receptor signaling pathway (GO:0035590)3.22453691
44monoubiquitinated protein deubiquitination (GO:0035520)3.22123700
45NAD biosynthetic process (GO:0009435)3.20331599
46regulation of interferon-alpha production (GO:0032647)3.19024517
47immunoglobulin mediated immune response (GO:0016064)3.18755871
48detection of biotic stimulus (GO:0009595)3.14577080
49response to muramyl dipeptide (GO:0032495)3.11954117
50negative regulation of B cell proliferation (GO:0030889)3.11506141
51establishment of protein localization to Golgi (GO:0072600)3.04059855
52endocrine hormone secretion (GO:0060986)3.03557265
53energy homeostasis (GO:0097009)2.97324029
54positive regulation of interferon-beta production (GO:0032728)2.93191154
55protein K48-linked deubiquitination (GO:0071108)2.90945045
56regulation of glucocorticoid secretion (GO:2000849)2.89545414
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88928792
58regulation of inositol phosphate biosynthetic process (GO:0010919)2.88542676
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88349514
60regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.88184434
61positive regulation of circadian rhythm (GO:0042753)2.86896052
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85563656
63response to host (GO:0075136)2.84277396
64response to host defenses (GO:0052200)2.84277396
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.84277396
66negative regulation of T cell mediated immunity (GO:0002710)2.83238455
67cellular response to exogenous dsRNA (GO:0071360)2.82740611
68neutrophil activation (GO:0042119)2.81766892
69negative regulation of glycoprotein biosynthetic process (GO:0010561)2.80859152
70macrophage activation (GO:0042116)2.80645549
71negative regulation of interleukin-6 production (GO:0032715)2.79369276
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78169473
73regulation of alpha-beta T cell proliferation (GO:0046640)2.78072057
74interkinetic nuclear migration (GO:0022027)2.76396787
75protein K11-linked deubiquitination (GO:0035871)2.75642958
76cellular response to interferon-gamma (GO:0071346)2.75111651
77regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74746630
78organelle membrane fusion (GO:0090174)2.71359082
79regulation of protein glycosylation (GO:0060049)2.70830845
80response to type I interferon (GO:0034340)2.66441628
81T-helper 1 type immune response (GO:0042088)2.64574230
82regulation of penile erection (GO:0060405)2.62357766
83cellular response to type I interferon (GO:0071357)2.60949074
84type I interferon signaling pathway (GO:0060337)2.60949074
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.60493218
86negative regulation of interleukin-12 production (GO:0032695)2.60173592
87GTP biosynthetic process (GO:0006183)2.59708666
88B cell receptor signaling pathway (GO:0050853)2.58859599
89defense response to protozoan (GO:0042832)2.58029826
90JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.57152850
91regulation of corticosteroid hormone secretion (GO:2000846)2.55994980
92toxin transport (GO:1901998)2.55457808
93skeletal muscle tissue regeneration (GO:0043403)2.54368325
94negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.54168576
95regulation of interleukin-1 beta production (GO:0032651)2.53091346
96regulation of MHC class I biosynthetic process (GO:0045343)2.52512810
97negative regulation of cell killing (GO:0031342)2.52145289
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.52145289
99myeloid cell activation involved in immune response (GO:0002275)2.51708489
100phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.50895268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.08103252
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.34379471
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17501283
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.16656776
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04288757
6SCL_19346495_ChIP-Seq_HPC-7_Human2.92261045
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64635845
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62306095
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.56186868
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.29601422
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19470211
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.07947410
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.07572907
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01193258
15IRF8_27001747_Chip-Seq_BMDM_Mouse1.98560611
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97487720
17RUNX_20019798_ChIP-Seq_JUKART_Human1.97268701
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97207856
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96831155
20SPI1_23127762_ChIP-Seq_K562_Human1.94132648
21MYB_26560356_Chip-Seq_TH2_Human1.92422287
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91196056
23IGF1R_20145208_ChIP-Seq_DFB_Human1.81583877
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79789863
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76743608
26SPI1_23547873_ChIP-Seq_NB4_Human1.75459190
27VDR_24787735_ChIP-Seq_THP-1_Human1.73781569
28PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67763590
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61483470
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54767499
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54245427
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53498738
33GATA1_22025678_ChIP-Seq_K562_Human1.52409171
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49990072
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48695261
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46141413
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46129302
38GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45123745
39GATA3_26560356_Chip-Seq_TH2_Human1.36446460
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34197176
41MYB_26560356_Chip-Seq_TH1_Human1.33963443
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32204145
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28385095
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.28316482
45ER_23166858_ChIP-Seq_MCF-7_Human1.28308539
46AR_21572438_ChIP-Seq_LNCaP_Human1.27119142
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25816769
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.23079844
49GATA3_27048872_Chip-Seq_THYMUS_Human1.22696334
50TAF15_26573619_Chip-Seq_HEK293_Human1.17053307
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15695326
52VDR_22108803_ChIP-Seq_LS180_Human1.15088632
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13561338
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12546274
55TCF4_23295773_ChIP-Seq_U87_Human1.09819506
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09724037
57STAT3_23295773_ChIP-Seq_U87_Human1.09273546
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09029571
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08391281
60TCF4_22108803_ChIP-Seq_LS180_Human1.07830063
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.06431125
62SMAD4_21799915_ChIP-Seq_A2780_Human1.05475042
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.04825731
64ZNF274_21170338_ChIP-Seq_K562_Hela1.04809907
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.04742247
66CDX2_22108803_ChIP-Seq_LS180_Human1.03051007
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02786107
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.01629033
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00010443
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99995799
71NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97473337
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97473337
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97229396
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93758685
75SALL4_22934838_ChIP-ChIP_CD34+_Human0.93077795
76SOX2_19829295_ChIP-Seq_ESCs_Human0.92303535
77NANOG_19829295_ChIP-Seq_ESCs_Human0.92303535
78PU_27001747_Chip-Seq_BMDM_Mouse0.91625967
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91376086
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91203134
81CBP_20019798_ChIP-Seq_JUKART_Human0.90882823
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90882823
83E2F1_18555785_Chip-Seq_ESCs_Mouse0.90865326
84CIITA_25753668_ChIP-Seq_RAJI_Human0.90654012
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89504832
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88511720
87CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88034456
88OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88005395
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87817813
90AR_20517297_ChIP-Seq_VCAP_Human0.87548824
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87269398
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86870759
93MAF_26560356_Chip-Seq_TH1_Human0.86761225
94TP63_23658742_ChIP-Seq_EP156T_Human0.86687185
95ESR1_20079471_ChIP-ChIP_T-47D_Human0.86480914
96P300_19829295_ChIP-Seq_ESCs_Human0.86251964
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85090283
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84927774
99LXR_22158963_ChIP-Seq_LIVER_Mouse0.84859747
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84761597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.41962821
2MP0000569_abnormal_digit_pigmentation4.37667222
3MP0003724_increased_susceptibility_to3.23361703
4MP0003045_fibrosis2.96208943
5MP0002396_abnormal_hematopoietic_system2.47193334
6MP0001800_abnormal_humoral_immune2.46525641
7MP0003436_decreased_susceptibility_to2.44332836
8MP0005671_abnormal_response_to2.38356511
9MP0003300_gastrointestinal_ulcer2.35715199
10MP0003646_muscle_fatigue2.25823771
11MP0002419_abnormal_innate_immunity2.17251907
12MP0002723_abnormal_immune_serum2.16057900
13MP0002452_abnormal_antigen_presenting2.08614770
14MP0009785_altered_susceptibility_to2.07847380
15MP0005025_abnormal_response_to2.07528092
16MP0005000_abnormal_immune_tolerance2.01859510
17MP0000685_abnormal_immune_system1.92470977
18MP0001790_abnormal_immune_system1.91147681
19MP0005387_immune_system_phenotype1.91147681
20MP0003303_peritoneal_inflammation1.90944860
21MP0001819_abnormal_immune_cell1.86326343
22MP0002420_abnormal_adaptive_immunity1.85845654
23MP0001853_heart_inflammation1.75102656
24MP0005174_abnormal_tail_pigmentation1.72084265
25MP0003763_abnormal_thymus_physiology1.71581823
26MP0002405_respiratory_system_inflammati1.69294089
27MP0008995_early_reproductive_senescence1.66523913
28MP0002166_altered_tumor_susceptibility1.64927462
29MP0005451_abnormal_body_composition1.56770044
30MP0004142_abnormal_muscle_tone1.56145972
31MP0009764_decreased_sensitivity_to1.53491771
32MP0003866_abnormal_defecation1.50172093
33MP0009115_abnormal_fat_cell1.48495575
34MP0004883_abnormal_blood_vessel1.48219786
35MP0000716_abnormal_immune_system1.46287042
36MP0003828_pulmonary_edema1.45461787
37MP0001440_abnormal_grooming_behavior1.42203754
38MP0001501_abnormal_sleep_pattern1.40308684
39MP0002398_abnormal_bone_marrow1.38701347
40MP0005266_abnormal_metabolism1.38685815
41MP0006054_spinal_hemorrhage1.36899468
42MP0003718_maternal_effect1.34183813
43MP0002009_preneoplasia1.33429717
44MP0002138_abnormal_hepatobiliary_system1.30755890
45MP0006082_CNS_inflammation1.25059076
46MP0002148_abnormal_hypersensitivity_rea1.25057633
47MP0004484_altered_response_of1.22378250
48MP0001845_abnormal_inflammatory_respons1.21910346
49MP0004381_abnormal_hair_follicle1.21372346
50MP0004947_skin_inflammation1.16653024
51MP0005395_other_phenotype1.15358229
52MP0003191_abnormal_cellular_cholesterol1.15084639
53MP0001545_abnormal_hematopoietic_system1.14018351
54MP0005397_hematopoietic_system_phenotyp1.14018351
55MP0004808_abnormal_hematopoietic_stem1.13647066
56MP0000230_abnormal_systemic_arterial1.13414707
57MP0000689_abnormal_spleen_morphology1.12986809
58MP0002722_abnormal_immune_system1.11944599
59MP0002168_other_aberrant_phenotype1.10069053
60MP0008961_abnormal_basal_metabolism1.09136463
61MP0000427_abnormal_hair_cycle1.08540917
62MP0003656_abnormal_erythrocyte_physiolo1.08385381
63MP0008260_abnormal_autophagy1.08357371
64MP0001533_abnormal_skeleton_physiology1.08130199
65MP0002693_abnormal_pancreas_physiology1.08083169
66MP0002429_abnormal_blood_cell1.07192204
67MP0000465_gastrointestinal_hemorrhage1.06356254
68MP0003195_calcinosis1.04467925
69MP0005448_abnormal_energy_balance1.04452235
70MP0010155_abnormal_intestine_physiology1.00244298
71MP0005164_abnormal_response_to0.99337345
72MP0004043_abnormal_pH_regulation0.98173646
73MP0003279_aneurysm0.96843134
74MP0008469_abnormal_protein_level0.95696683
75MP0002332_abnormal_exercise_endurance0.94894425
76MP0004215_abnormal_myocardial_fiber0.93987042
77MP0002006_tumorigenesis0.91775373
78MP0004145_abnormal_muscle_electrophysio0.91622731
79MP0004130_abnormal_muscle_cell0.88475172
80MP0005376_homeostasis/metabolism_phenot0.86812878
81MP0003252_abnormal_bile_duct0.86153412
82MP0010352_gastrointestinal_tract_polyps0.85376002
83MP0005334_abnormal_fat_pad0.85009928
84MP0003172_abnormal_lysosome_physiology0.84945310
85MP0003690_abnormal_glial_cell0.84328122
86MP0001851_eye_inflammation0.84037722
87MP0005464_abnormal_platelet_physiology0.80320041
88MP0001542_abnormal_bone_strength0.80116543
89MP0008877_abnormal_DNA_methylation0.79811840
90MP0005058_abnormal_lysosome_morphology0.79276060
91MP0003638_abnormal_response/metabolism_0.78147727
92MP0009278_abnormal_bone_marrow0.77910744
93MP0003943_abnormal_hepatobiliary_system0.77899353
94MP0002095_abnormal_skin_pigmentation0.77220774
95MP0005083_abnormal_biliary_tract0.77009485
96MP0001986_abnormal_taste_sensitivity0.75905664
97MP0002998_abnormal_bone_remodeling0.74009114
98MP0002876_abnormal_thyroid_physiology0.73475781
99MP0000703_abnormal_thymus_morphology0.73051207
100MP0009763_increased_sensitivity_to0.68551772

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)4.68743989
2Genetic anticipation (HP:0003743)4.03633139
3Increased neuronal autofluorescent lipopigment (HP:0002074)3.76489760
4Fatigue (HP:0012378)3.59075713
5Myositis (HP:0100614)3.55733329
6Gaze-evoked nystagmus (HP:0000640)3.54981496
7Recurrent cutaneous fungal infections (HP:0011370)3.54035854
8Chronic mucocutaneous candidiasis (HP:0002728)3.54035854
9Eczematoid dermatitis (HP:0000976)3.52071046
10Recurrent abscess formation (HP:0002722)3.51126694
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.48719184
12Recurrent fungal infections (HP:0002841)3.45165219
13Retrobulbar optic neuritis (HP:0100654)3.35506285
14Optic neuritis (HP:0100653)3.35506285
15Increased cerebral lipofuscin (HP:0011813)3.25810112
16Gastrointestinal infarctions (HP:0005244)3.21743247
17Orchitis (HP:0100796)3.13972862
18Recurrent bacterial skin infections (HP:0005406)3.09010446
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07401381
20Cerebral hemorrhage (HP:0001342)3.07123163
21Recurrent bronchitis (HP:0002837)3.02810585
22Spontaneous abortion (HP:0005268)3.01886323
23Gingival bleeding (HP:0000225)2.97207407
24Elevated erythrocyte sedimentation rate (HP:0003565)2.96894712
25Thrombocytosis (HP:0001894)2.93418084
26Recurrent skin infections (HP:0001581)2.93149481
27Chest pain (HP:0100749)2.91870811
28Progressive cerebellar ataxia (HP:0002073)2.86365177
29Chronic sinusitis (HP:0011109)2.84080416
30Acute myeloid leukemia (HP:0004808)2.76283161
31Recurrent gram-negative bacterial infections (HP:0005420)2.72070274
32Loss of speech (HP:0002371)2.66363182
33Hemoptysis (HP:0002105)2.65645679
34Meningitis (HP:0001287)2.65238158
35Parakeratosis (HP:0001036)2.63971494
36Obstructive lung disease (HP:0006536)2.62570688
37Chronic obstructive pulmonary disease (HP:0006510)2.62570688
38Vasculitis (HP:0002633)2.60706010
39Inflammation of the large intestine (HP:0002037)2.57971832
40Diplopia (HP:0000651)2.57720631
41Abnormality of binocular vision (HP:0011514)2.57720631
42Erythema (HP:0010783)2.50483261
43Macular degeneration (HP:0000608)2.48342460
44Arterial thrombosis (HP:0004420)2.46339071
45Gangrene (HP:0100758)2.42857629
46Autoimmune hemolytic anemia (HP:0001890)2.42437924
47Abnormality of T cell physiology (HP:0011840)2.39249917
48Stomatitis (HP:0010280)2.38397044
49Constricted visual fields (HP:0001133)2.34419913
50Clumsiness (HP:0002312)2.32557331
51Colitis (HP:0002583)2.32060122
52Spontaneous hematomas (HP:0007420)2.29763948
53Impaired smooth pursuit (HP:0007772)2.28067958
54Abnormality of T cell number (HP:0011839)2.27373591
55Abnormality of T cells (HP:0002843)2.25333293
56Acute hepatic failure (HP:0006554)2.25246340
57Pulmonary infiltrates (HP:0002113)2.22858949
58Decreased central vision (HP:0007663)2.20649297
59Urticaria (HP:0001025)2.18942244
60Keratoconjunctivitis sicca (HP:0001097)2.18142896
61Hyperventilation (HP:0002883)2.17957681
62T lymphocytopenia (HP:0005403)2.17227320
63Impaired vibratory sensation (HP:0002495)2.17201839
64Abnormality of ocular smooth pursuit (HP:0000617)2.16829699
65Autoimmune thrombocytopenia (HP:0001973)2.14766516
66Keratoconjunctivitis (HP:0001096)2.14169875
67Mediastinal lymphadenopathy (HP:0100721)2.14141978
68Dysmetric saccades (HP:0000641)2.13051827
69Sensory axonal neuropathy (HP:0003390)2.11602653
70Gastrointestinal inflammation (HP:0004386)2.10994191
71Panhypogammaglobulinemia (HP:0003139)2.10303042
72Papilledema (HP:0001085)2.08541141
73Abnormality of the prostate (HP:0008775)2.08420814
74Hypergammaglobulinemia (HP:0010702)2.07707464
75Encephalitis (HP:0002383)2.07614835
76Abnormality of the columella (HP:0009929)2.06729783
77Vertigo (HP:0002321)2.05531164
78Areflexia of lower limbs (HP:0002522)2.04751512
79Epistaxis (HP:0000421)2.03807872
80Hemiplegia (HP:0002301)2.01137518
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99810927
82Leukocytosis (HP:0001974)1.98361264
83Frequent falls (HP:0002359)1.97837292
84Bronchitis (HP:0012387)1.97747796
85Polyneuropathy (HP:0001271)1.96342761
86Cheilitis (HP:0100825)1.94734944
87Pancreatic cysts (HP:0001737)1.94287594
88Abnormality of the pleura (HP:0002103)1.93620141
89Prominent nose (HP:0000448)1.93438261
90Abolished electroretinogram (ERG) (HP:0000550)1.91690827
91Tinnitus (HP:0000360)1.91081360
92Cone-rod dystrophy (HP:0000548)1.91014820
93Eosinophilia (HP:0001880)1.90509258
94Peritonitis (HP:0002586)1.87745041
95Exertional dyspnea (HP:0002875)1.87040309
96Granulocytopenia (HP:0001913)1.86174157
97Gingivitis (HP:0000230)1.85999486
98Amaurosis fugax (HP:0100576)1.85391917
99Recurrent viral infections (HP:0004429)1.83646607
100Amyloidosis (HP:0011034)1.83458051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.39027219
2FRK3.64169717
3BRD42.64685155
4STK242.54887441
5MAP4K12.48438038
6BLK2.46027428
7EPHA32.36633052
8RIPK42.28459350
9TLK12.15037701
10KIT2.08432619
11TXK1.99218305
12NLK1.96175995
13JAK31.95257882
14PIK3CG1.94416968
15TYK21.92028705
16TEC1.82322530
17EPHB11.81662949
18MAP3K41.76471974
19MST41.74891390
20MARK31.74420596
21IRAK11.71400895
22CSF1R1.71033608
23BMPR21.69634283
24CAMKK21.66078807
25BMPR1B1.66023506
26JAK11.53934055
27FGFR31.50376150
28MAP4K21.49728854
29BRSK21.43200581
30SYK1.36127030
31JAK21.34997332
32BTK1.32600427
33FES1.25449865
34FGR1.23604777
35MAP3K61.23354415
36TNK21.20005065
37HCK1.19815342
38AKT31.19505353
39CAMK1G1.19474818
40ZAP701.16788242
41ITK1.08650454
42IKBKE1.06799522
43TGFBR11.02766888
44CDK191.02557899
45MAP3K21.01101999
46LYN0.98573824
47PTK2B0.96688076
48SIK30.93310194
49TNIK0.93118282
50FLT30.89856406
51CSK0.89540605
52FER0.84269477
53MAP2K70.83946141
54CAMK1D0.83113157
55MAP2K40.82754112
56RET0.80221960
57WNK10.79307628
58FGFR40.72929640
59MAP3K140.72451395
60CASK0.71968030
61CDK120.69248026
62STK30.69050421
63PRKCE0.69034524
64IRAK40.66794908
65SGK20.63299703
66LRRK20.62328743
67PAK30.61421088
68MARK20.60999172
69GRK70.60094379
70MAP3K50.55883879
71MATK0.54134228
72PIM10.54045991
73MAP2K30.53182828
74LCK0.52341296
75NUAK10.48915663
76PRKAA20.48021728
77MAPK70.46581884
78NME10.44927430
79HIPK20.44121211
80STK100.43232748
81NEK90.42756342
82DMPK0.42175898
83IKBKB0.41871135
84PRKCQ0.41795839
85TGFBR20.39934507
86PIK3CA0.39728105
87MAP2K60.39636632
88PDGFRB0.39491917
89ABL10.39094091
90ADRBK10.38854577
91ERBB20.38411394
92TRPM70.37527904
93INSRR0.36297890
94GRK10.35959092
95CDC42BPA0.35092035
96RPS6KA50.34459762
97ERBB30.32785934
98MKNK20.32399872
99CAMK10.28409998
100IGF1R0.28129023

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.55006960
2Allograft rejection_Homo sapiens_hsa053303.95005176
3Graft-versus-host disease_Homo sapiens_hsa053323.91097089
4Autoimmune thyroid disease_Homo sapiens_hsa053203.69795183
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.58502161
6Type I diabetes mellitus_Homo sapiens_hsa049403.43996944
7Staphylococcus aureus infection_Homo sapiens_hsa051503.43040389
8Leishmaniasis_Homo sapiens_hsa051403.06596281
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.03689821
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.25465990
11Antigen processing and presentation_Homo sapiens_hsa046122.05255100
12Tuberculosis_Homo sapiens_hsa051521.95624744
13Viral myocarditis_Homo sapiens_hsa054161.88065159
14Rheumatoid arthritis_Homo sapiens_hsa053231.86500745
15Influenza A_Homo sapiens_hsa051641.85721593
16Toxoplasmosis_Homo sapiens_hsa051451.77591334
17Herpes simplex infection_Homo sapiens_hsa051681.45142815
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40215361
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.39606976
20Osteoclast differentiation_Homo sapiens_hsa043801.30706352
21Hematopoietic cell lineage_Homo sapiens_hsa046401.29205407
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25960523
23Circadian rhythm_Homo sapiens_hsa047101.21092193
24Measles_Homo sapiens_hsa051621.17459438
25Malaria_Homo sapiens_hsa051441.17310215
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.14565122
27Regulation of autophagy_Homo sapiens_hsa041401.11497595
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11023750
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09935113
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.08109787
31Primary immunodeficiency_Homo sapiens_hsa053401.06820190
32Phagosome_Homo sapiens_hsa041451.01180375
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94045872
34African trypanosomiasis_Homo sapiens_hsa051430.90707813
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83699904
36Platelet activation_Homo sapiens_hsa046110.77982316
37Taste transduction_Homo sapiens_hsa047420.73804204
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73343498
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73102593
40Hepatitis C_Homo sapiens_hsa051600.72884720
41B cell receptor signaling pathway_Homo sapiens_hsa046620.71498544
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71208522
43Homologous recombination_Homo sapiens_hsa034400.68229384
44TNF signaling pathway_Homo sapiens_hsa046680.67543749
45Acute myeloid leukemia_Homo sapiens_hsa052210.64733172
46HIF-1 signaling pathway_Homo sapiens_hsa040660.64142330
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63258601
48ABC transporters_Homo sapiens_hsa020100.62582175
49Type II diabetes mellitus_Homo sapiens_hsa049300.62475862
50Dorso-ventral axis formation_Homo sapiens_hsa043200.60271356
51Systemic lupus erythematosus_Homo sapiens_hsa053220.59882581
52Peroxisome_Homo sapiens_hsa041460.57006653
53Olfactory transduction_Homo sapiens_hsa047400.55350319
54Insulin resistance_Homo sapiens_hsa049310.54997011
55Hepatitis B_Homo sapiens_hsa051610.54889310
56Epstein-Barr virus infection_Homo sapiens_hsa051690.53947546
57Chemokine signaling pathway_Homo sapiens_hsa040620.53220502
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50792865
59Legionellosis_Homo sapiens_hsa051340.48709794
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46354469
61mTOR signaling pathway_Homo sapiens_hsa041500.45997143
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45192678
63Pertussis_Homo sapiens_hsa051330.44563465
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43431264
65Choline metabolism in cancer_Homo sapiens_hsa052310.42478931
66Prolactin signaling pathway_Homo sapiens_hsa049170.41652251
67Non-homologous end-joining_Homo sapiens_hsa034500.41404190
68Glycerolipid metabolism_Homo sapiens_hsa005610.41178569
69Histidine metabolism_Homo sapiens_hsa003400.40702334
70cAMP signaling pathway_Homo sapiens_hsa040240.40093855
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38458599
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36038627
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.34255657
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32594876
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31578135
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.30750011
77Salivary secretion_Homo sapiens_hsa049700.30630835
78Sphingolipid metabolism_Homo sapiens_hsa006000.30559322
79FoxO signaling pathway_Homo sapiens_hsa040680.30342373
80Renin-angiotensin system_Homo sapiens_hsa046140.29435081
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28965794
82Arachidonic acid metabolism_Homo sapiens_hsa005900.28779732
83T cell receptor signaling pathway_Homo sapiens_hsa046600.27376899
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.27046905
85Collecting duct acid secretion_Homo sapiens_hsa049660.26883910
86Morphine addiction_Homo sapiens_hsa050320.26552588
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26114105
88Shigellosis_Homo sapiens_hsa051310.22970619
89HTLV-I infection_Homo sapiens_hsa051660.22119189
90Renal cell carcinoma_Homo sapiens_hsa052110.21804981
91Serotonergic synapse_Homo sapiens_hsa047260.20061371
92Oxytocin signaling pathway_Homo sapiens_hsa049210.19984281
93Pancreatic cancer_Homo sapiens_hsa052120.19848422
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19428918
95Cholinergic synapse_Homo sapiens_hsa047250.19380869
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19238198
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18052051
98Oxidative phosphorylation_Homo sapiens_hsa001900.17260327
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.16967021
100Cocaine addiction_Homo sapiens_hsa050300.16897177

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