ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of response to food (GO:0032095)	6.16385839
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.80410012
3	ATP synthesis coupled proton transport (GO:0015986)	5.80410012
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.72891867
5	cellular response to nitric oxide (GO:0071732)	5.72235552
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.56781460
7	ribosomal small subunit biogenesis (GO:0042274)	4.98967075
8	respiratory electron transport chain (GO:0022904)	4.88409319
9	cellular response to leptin stimulus (GO:0044320)	4.83000230
10	electron transport chain (GO:0022900)	4.79443582
11	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	4.78661472
12	negative regulation of appetite (GO:0032099)	4.61147548
13	negative regulation of response to food (GO:0032096)	4.61147548
14	response to leptin (GO:0044321)	4.59096434
15	neurofilament cytoskeleton organization (GO:0060052)	4.52938074
16	viral transcription (GO:0019083)	4.52132655
17	cellular response to oxygen radical (GO:0071450)	4.46615892
18	removal of superoxide radicals (GO:0019430)	4.46615892
19	cellular response to superoxide (GO:0071451)	4.46615892
20	cellular response to cadmium ion (GO:0071276)	4.42518246
21	translational termination (GO:0006415)	4.32392006
22	positive regulation of potassium ion transmembrane transport (GO:1901381)	4.29295200
23	chaperone-mediated protein transport (GO:0072321)	4.27252323
24	sterol catabolic process (GO:0016127)	4.24761848
25	cholesterol catabolic process (GO:0006707)	4.24761848
26	glutamate secretion (GO:0014047)	4.16182264
27	negative regulation of necrotic cell death (GO:0060547)	4.14358325
28	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.11543965
29	response to nitric oxide (GO:0071731)	4.06250480
30	protein complex biogenesis (GO:0070271)	4.03937852
31	astrocyte development (GO:0014002)	4.01920982
32	ATP biosynthetic process (GO:0006754)	3.91350101
33	cellular response to reactive nitrogen species (GO:1902170)	3.86396922
34	cellular zinc ion homeostasis (GO:0006882)	3.85088269
35	axon ensheathment in central nervous system (GO:0032291)	3.82805376
36	central nervous system myelination (GO:0022010)	3.82805376
37	synaptic vesicle exocytosis (GO:0016079)	3.81566547
38	regulation of protein glycosylation (GO:0060049)	3.74835160
39	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.70460738
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.64538823
41	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	3.62785718
42	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.60502246
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.60088013
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.60088013
45	NADH dehydrogenase complex assembly (GO:0010257)	3.60088013
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.50826057
47	activation of protein kinase B activity (GO:0032148)	3.50723799
48	translational elongation (GO:0006414)	3.50658623
49	relaxation of smooth muscle (GO:0044557)	3.50032952
50	response to superoxide (GO:0000303)	3.46600218
51	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.43005143
52	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.42828382
53	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.41551704
54	protein targeting to ER (GO:0045047)	3.37347810
55	cotranslational protein targeting to membrane (GO:0006613)	3.37087065
56	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.35916033
57	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.35855117
58	behavioral response to cocaine (GO:0048148)	3.34748591
59	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.34160279
60	substrate-independent telencephalic tangential migration (GO:0021826)	3.34160279
61	sleep (GO:0030431)	3.32980721
62	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.32756326
63	response to oxygen radical (GO:0000305)	3.30294072
64	cellular protein complex disassembly (GO:0043624)	3.27221084
65	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.25179833
66	protein localization to endoplasmic reticulum (GO:0070972)	3.22020602
67	hydrogen ion transmembrane transport (GO:1902600)	3.16468115
68	zinc ion homeostasis (GO:0055069)	3.13772418
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.13653667
70	oxidative phosphorylation (GO:0006119)	3.13148527
71	positive regulation of potassium ion transport (GO:0043268)	3.12270814
72	neuronal action potential propagation (GO:0019227)	3.11709382
73	cellular potassium ion homeostasis (GO:0030007)	3.11091117
74	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.10906390
75	regulation of voltage-gated calcium channel activity (GO:1901385)	3.10879466
76	urinary tract smooth muscle contraction (GO:0014848)	3.10568677
77	regulation of sensory perception of pain (GO:0051930)	3.10524288
78	regulation of sensory perception (GO:0051931)	3.10524288
79	positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)	3.09744036
80	viral life cycle (GO:0019058)	3.09719814
81	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.05161862
82	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.97814243
83	regulation of membrane repolarization (GO:0060306)	2.97515500
84	behavioral defense response (GO:0002209)	2.97022952
85	behavioral fear response (GO:0001662)	2.97022952
86	negative regulation of axon extension (GO:0030517)	2.96524855
87	membrane repolarization (GO:0086009)	2.96230613
88	regulation of potassium ion transmembrane transport (GO:1901379)	2.94537553
89	adaptation of signaling pathway (GO:0023058)	2.93140581
90	startle response (GO:0001964)	2.92872963
91	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	2.90854818
92	detection of temperature stimulus involved in sensory perception (GO:0050961)	2.90854818
93	regulation of appetite (GO:0032098)	2.87637148
94	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.87028892
95	regulation of potassium ion transport (GO:0043266)	2.83011099
96	positive regulation of synapse maturation (GO:0090129)	2.81411793
97	behavioral response to nicotine (GO:0035095)	2.80224003
98	response to histamine (GO:0034776)	2.80103180
99	pyrimidine nucleotide catabolic process (GO:0006244)	2.79806791
100	fear response (GO:0042596)	2.78665848

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.21696277
2	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.36944705
3	EZH2_27304074_Chip-Seq_ESCs_Mouse	3.01776859
4	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.91998422
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.86904626
6	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.80550328
7	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.75115344
8	REST_21632747_ChIP-Seq_MESCs_Mouse	2.68987980
9	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.61194975
10	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.60826198
11	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.60364917
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.55114383
13	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.45614436
14	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.45614436
15	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.43776671
16	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.33054584
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.25375305
18	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.16648057
19	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.15038807
20	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.13881677
21	GBX2_23144817_ChIP-Seq_PC3_Human	2.12647054
22	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.12436437
23	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.12002034
24	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.11199384
25	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.99227931
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95487479
27	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.92153173
28	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.90097987
29	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.85548165
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.83355711
31	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.80273894
32	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.72701358
33	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.71269395
34	VDR_22108803_ChIP-Seq_LS180_Human	1.67654168
35	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.55919620
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.52740506
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52034871
38	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.51213654
39	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.50891190
40	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.45578600
41	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.44307871
42	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.37130280
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.35899301
44	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.34876466
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.34128326
46	HTT_18923047_ChIP-ChIP_STHdh_Human	1.32915402
47	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.31761118
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.29096594
49	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.29024409
50	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27518683
51	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.23216771
52	CTCF_27219007_Chip-Seq_Bcells_Human	1.21443432
53	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.19581796
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19288193
55	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.17945842
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.15798628
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12824229
58	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12719319
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12369924
60	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10506005
61	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07440422
62	FUS_26573619_Chip-Seq_HEK293_Human	1.06491267
63	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.06039204
64	CTCF_20526341_ChIP-Seq_ESCs_Human	1.05143396
65	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.04116508
66	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01640093
67	MYC_18940864_ChIP-ChIP_HL60_Human	0.98884860
68	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.98554786
69	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97655487
70	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94613797
71	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.94132176
72	DROSHA_22980978_ChIP-Seq_HELA_Human	0.93688462
73	TP53_22573176_ChIP-Seq_HFKS_Human	0.93524295
74	P300_19829295_ChIP-Seq_ESCs_Human	0.92895296
75	EWS_26573619_Chip-Seq_HEK293_Human	0.90289437
76	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.89858706
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.88914831
78	MYC_19829295_ChIP-Seq_ESCs_Human	0.87341018
79	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.87320220
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.85953918
81	ERA_21632823_ChIP-Seq_H3396_Human	0.85132023
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.85071422
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.84397969
84	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.84078834
85	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.83313580
86	NCOR_22424771_ChIP-Seq_293T_Human	0.82919632
87	JUN_21703547_ChIP-Seq_K562_Human	0.82374573
88	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.82114608
89	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.81503277
90	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.81466805
91	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.81313900
92	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.79850549
93	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.78698705
94	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.78650893
95	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.78242813
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.78126041
97	SMAD4_21799915_ChIP-Seq_A2780_Human	0.77704335
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.77432593
99	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.77397470
100	AR_25329375_ChIP-Seq_VCAP_Human	0.76989298

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.27788732
2	MP0009745_abnormal_behavioral_response	3.16316118
3	MP0009046_muscle_twitch	3.03307736
4	MP0002064_seizures	3.02400133
5	MP0004885_abnormal_endolymph	2.91894853
6	MP0003787_abnormal_imprinting	2.90763462
7	MP0003635_abnormal_synaptic_transmissio	2.78737260
8	MP0002272_abnormal_nervous_system	2.67661802
9	MP0004859_abnormal_synaptic_plasticity	2.64659435
10	MP0001188_hyperpigmentation	2.57673330
11	MP0001968_abnormal_touch/_nociception	2.43844495
12	MP0008877_abnormal_DNA_methylation	2.43318777
13	MP0003879_abnormal_hair_cell	2.41895618
14	MP0003880_abnormal_central_pattern	2.34244314
15	MP0005646_abnormal_pituitary_gland	2.24744103
16	MP0003123_paternal_imprinting	2.22790807
17	MP0006292_abnormal_olfactory_placode	2.19269616
18	MP0001485_abnormal_pinna_reflex	2.04924017
19	MP0001905_abnormal_dopamine_level	2.01675743
20	MP0001486_abnormal_startle_reflex	1.99398045
21	MP0010386_abnormal_urinary_bladder	1.98367921
22	MP0002733_abnormal_thermal_nociception	1.97699706
23	MP0002735_abnormal_chemical_nociception	1.94740892
24	MP0002063_abnormal_learning/memory/cond	1.94521463
25	MP0002736_abnormal_nociception_after	1.91527151
26	MP0005551_abnormal_eye_electrophysiolog	1.88143373
27	MP0002572_abnormal_emotion/affect_behav	1.86287461
28	MP0004270_analgesia	1.85586179
29	MP0005423_abnormal_somatic_nervous	1.83421564
30	MP0001970_abnormal_pain_threshold	1.82027677
31	MP0002837_dystrophic_cardiac_calcinosis	1.70466192
32	MP0001984_abnormal_olfaction	1.70414328
33	MP0002163_abnormal_gland_morphology	1.67575449
34	MP0001440_abnormal_grooming_behavior	1.66467656
35	MP0000955_abnormal_spinal_cord	1.65151611
36	MP0002234_abnormal_pharynx_morphology	1.64877234
37	MP0004043_abnormal_pH_regulation	1.60983713
38	MP0001501_abnormal_sleep_pattern	1.57417318
39	MP0002734_abnormal_mechanical_nocicepti	1.51053824
40	MP0000049_abnormal_middle_ear	1.49565344
41	MP0003011_delayed_dark_adaptation	1.48575151
42	MP0004742_abnormal_vestibular_system	1.48267425
43	MP0001963_abnormal_hearing_physiology	1.42234341
44	MP0006036_abnormal_mitochondrial_physio	1.41818024
45	MP0004145_abnormal_muscle_electrophysio	1.41047207
46	MP0002067_abnormal_sensory_capabilities	1.34017190
47	MP0002557_abnormal_social/conspecific_i	1.32866760
48	MP0002822_catalepsy	1.30707272
49	MP0000631_abnormal_neuroendocrine_gland	1.27716852
50	MP0004142_abnormal_muscle_tone	1.24265999
51	MP0002160_abnormal_reproductive_system	1.19898016
52	MP0002882_abnormal_neuron_morphology	1.19476709
53	MP0006276_abnormal_autonomic_nervous	1.18351266
54	MP0003633_abnormal_nervous_system	1.18198386
55	MP0004147_increased_porphyrin_level	1.14758502
56	MP0000026_abnormal_inner_ear	1.13309777
57	MP0003121_genomic_imprinting	1.12496427
58	MP0002638_abnormal_pupillary_reflex	1.11718345
59	MP0002184_abnormal_innervation	1.11504706
60	MP0002066_abnormal_motor_capabilities/c	1.11186535
61	MP0000678_abnormal_parathyroid_gland	1.10266403
62	MP0004811_abnormal_neuron_physiology	1.08130484
63	MP0005386_behavior/neurological_phenoty	1.06382541
64	MP0004924_abnormal_behavior	1.06382541
65	MP0002752_abnormal_somatic_nervous	1.04996957
66	MP0005636_abnormal_mineral_homeostasis	1.02864111
67	MP0001502_abnormal_circadian_rhythm	1.02522165
68	MP0002229_neurodegeneration	1.01771737
69	MP0008875_abnormal_xenobiotic_pharmacok	1.01740153
70	MP0008872_abnormal_physiological_respon	0.97731002
71	MP0000778_abnormal_nervous_system	0.97607022
72	MP0005389_reproductive_system_phenotype	0.93940622
73	MP0003938_abnormal_ear_development	0.92489212
74	MP0003631_nervous_system_phenotype	0.91235894
75	MP0003136_yellow_coat_color	0.91134154
76	MP0008569_lethality_at_weaning	0.88671891
77	MP0001919_abnormal_reproductive_system	0.87399148
78	MP0003186_abnormal_redox_activity	0.86551858
79	MP0005379_endocrine/exocrine_gland_phen	0.85130828
80	MP0006072_abnormal_retinal_apoptosis	0.85001758
81	MP0004133_heterotaxia	0.84720892
82	MP0005332_abnormal_amino_acid	0.84689578
83	MP0005377_hearing/vestibular/ear_phenot	0.83726059
84	MP0003878_abnormal_ear_physiology	0.83726059
85	MP0002277_abnormal_respiratory_mucosa	0.81953036
86	MP0002876_abnormal_thyroid_physiology	0.81104947
87	MP0004215_abnormal_myocardial_fiber	0.80601984
88	MP0003137_abnormal_impulse_conducting	0.78183325
89	MP0002095_abnormal_skin_pigmentation	0.77117233
90	MP0005499_abnormal_olfactory_system	0.75182288
91	MP0005394_taste/olfaction_phenotype	0.75182288
92	MP0002249_abnormal_larynx_morphology	0.74301283
93	MP0003122_maternal_imprinting	0.74106974
94	MP0005195_abnormal_posterior_eye	0.72727180
95	MP0001664_abnormal_digestion	0.71944703
96	MP0002152_abnormal_brain_morphology	0.71625468
97	MP0001765_abnormal_ion_homeostasis	0.66258316
98	MP0005535_abnormal_body_temperature	0.65670463
99	MP0009780_abnormal_chondrocyte_physiolo	0.65454826
100	MP0003646_muscle_fatigue	0.65202322

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.72549205
2	Myokymia (HP:0002411)	4.70262959
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.64971638
4	Progressive macrocephaly (HP:0004481)	3.92937807
5	Mitochondrial inheritance (HP:0001427)	3.92810686
6	Acute encephalopathy (HP:0006846)	3.92419807
7	Focal seizures (HP:0007359)	3.90999902
8	Focal motor seizures (HP:0011153)	3.82902613
9	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.74241996
10	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.74241996
11	Hyperthyroidism (HP:0000836)	3.61491808
12	Atonic seizures (HP:0010819)	3.55223683
13	Increased intramyocellular lipid droplets (HP:0012240)	3.53831398
14	Congenital malformation of the right heart (HP:0011723)	3.45152854
15	Double outlet right ventricle (HP:0001719)	3.45152854
16	Renal Fanconi syndrome (HP:0001994)	3.39220049
17	Action tremor (HP:0002345)	3.36414526
18	Absence seizures (HP:0002121)	3.33905155
19	Increased CSF lactate (HP:0002490)	3.33356449
20	Epileptic encephalopathy (HP:0200134)	3.26086720
21	Increased muscle lipid content (HP:0009058)	3.15769042
22	Dialeptic seizures (HP:0011146)	3.13247010
23	Febrile seizures (HP:0002373)	3.10375562
24	Increased hepatocellular lipid droplets (HP:0006565)	3.04639180
25	Ventricular fibrillation (HP:0001663)	2.96746404
26	Lipid accumulation in hepatocytes (HP:0006561)	2.93441559
27	Abnormality of renal resorption (HP:0011038)	2.84919518
28	Hypoplastic left heart (HP:0004383)	2.83397283
29	Cerebral edema (HP:0002181)	2.79089235
30	Molar tooth sign on MRI (HP:0002419)	2.77003975
31	Abnormality of midbrain morphology (HP:0002418)	2.77003975
32	Macrocytic anemia (HP:0001972)	2.76951787
33	Generalized tonic-clonic seizures (HP:0002069)	2.66875237
34	Truncus arteriosus (HP:0001660)	2.59460484
35	Sclerocornea (HP:0000647)	2.48043490
36	Limb dystonia (HP:0002451)	2.45989895
37	Hepatocellular necrosis (HP:0001404)	2.45773529
38	Leukodystrophy (HP:0002415)	2.45465615
39	Progressive cerebellar ataxia (HP:0002073)	2.44571737
40	Abnormality of cells of the erythroid lineage (HP:0012130)	2.42273707
41	Congenital stationary night blindness (HP:0007642)	2.39539306
42	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.38861951
43	Absent/shortened dynein arms (HP:0200106)	2.38861951
44	3-Methylglutaconic aciduria (HP:0003535)	2.36541518
45	Pancreatic fibrosis (HP:0100732)	2.35289916
46	Abnormality of binocular vision (HP:0011514)	2.35091986
47	Diplopia (HP:0000651)	2.35091986
48	Amblyopia (HP:0000646)	2.30082319
49	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.29485934
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.27542308
51	Lactic acidosis (HP:0003128)	2.27387642
52	Hepatic necrosis (HP:0002605)	2.25017086
53	Respiratory failure (HP:0002878)	2.24869789
54	Status epilepticus (HP:0002133)	2.22360626
55	Hypoplastic heart (HP:0001961)	2.21083901
56	X-linked dominant inheritance (HP:0001423)	2.16637503
57	Agitation (HP:0000713)	2.16623759
58	Cerebral hypomyelination (HP:0006808)	2.16366803
59	Pigmentary retinal degeneration (HP:0001146)	2.14707047
60	Epileptiform EEG discharges (HP:0011182)	2.14481984
61	Abnormal number of erythroid precursors (HP:0012131)	2.10585285
62	Hyperphosphaturia (HP:0003109)	2.10405837
63	Exertional dyspnea (HP:0002875)	2.09612749
64	Periauricular skin pits (HP:0100277)	2.08776861
65	Preauricular pit (HP:0004467)	2.08776861
66	Abnormality of urine glucose concentration (HP:0011016)	2.06699138
67	Glycosuria (HP:0003076)	2.06699138
68	Syncope (HP:0001279)	2.06306858
69	Visual hallucinations (HP:0002367)	2.05781871
70	Nephronophthisis (HP:0000090)	2.02586082
71	Anxiety (HP:0000739)	2.01597615
72	Abnormal drinking behavior (HP:0030082)	1.97860096
73	Polydipsia (HP:0001959)	1.97860096
74	Exercise intolerance (HP:0003546)	1.97831338
75	Optic disc pallor (HP:0000543)	1.97685358
76	Pallor (HP:0000980)	1.94105921
77	Medial flaring of the eyebrow (HP:0010747)	1.93169842
78	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.93025947
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.91536607
80	True hermaphroditism (HP:0010459)	1.90687438
81	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.89163795
82	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.89163795
83	Increased serum lactate (HP:0002151)	1.89141698
84	Septo-optic dysplasia (HP:0100842)	1.88673864
85	Type 2 muscle fiber atrophy (HP:0003554)	1.86439019
86	Abnormality of magnesium homeostasis (HP:0004921)	1.85571983
87	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.85021822
88	Nonprogressive disorder (HP:0003680)	1.84627863
89	Hyperventilation (HP:0002883)	1.83892036
90	Hypoplasia of the uterus (HP:0000013)	1.82507947
91	Abnormal eating behavior (HP:0100738)	1.82346318
92	Respiratory difficulties (HP:0002880)	1.79049829
93	Abnormal number of incisors (HP:0011064)	1.77841898
94	Muscle fiber atrophy (HP:0100295)	1.77520385
95	Abnormal urine phosphate concentration (HP:0012599)	1.77233678
96	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.77066580
97	Tetany (HP:0001281)	1.75171423
98	Abnormality of the aortic arch (HP:0012303)	1.73724874
99	Reticulocytopenia (HP:0001896)	1.73560284
100	Restlessness (HP:0000711)	1.72874628

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.45995641
2	PINK1	3.25114976
3	NME2	2.88432860
4	NTRK3	2.68776716
5	DMPK	2.67125552
6	PAK3	2.44283573
7	WNK4	2.14016621
8	PRKCG	2.12381684
9	CDC7	1.86316626
10	NTRK2	1.75279291
11	UHMK1	1.74489881
12	CASK	1.71914080
13	DAPK2	1.68236791
14	CAMKK2	1.67957727
15	STK39	1.65100583
16	MINK1	1.61843550
17	EPHA4	1.59651568
18	BUB1	1.58298586
19	TNIK	1.55830912
20	CAMK2A	1.51347996
21	ADRBK2	1.46115449
22	MARK1	1.43086484
23	CAMK1	1.40508741
24	GRK5	1.38438978
25	MAP3K4	1.38364779
26	PAK6	1.37438594
27	FRK	1.35551515
28	CAMK2B	1.30900904
29	TAF1	1.27641541
30	VRK2	1.22861355
31	DAPK1	1.18755630
32	MAP2K7	1.17430251
33	SGK494	1.13839640
34	SGK223	1.13839640
35	PNCK	1.13795479
36	ABL2	1.13752300
37	CAMK2G	1.09381774
38	IRAK2	1.08677562
39	CAMKK1	1.06304304
40	NUAK1	1.05681856
41	CAMK2D	1.05442359
42	RIPK4	1.05229555
43	BRAF	1.04492142
44	TAOK3	1.01926312
45	PIK3CA	1.00163082
46	DYRK2	0.99318645
47	GRK1	0.97474241
48	CSNK1E	0.96518726
49	CSNK1G2	0.96093015
50	CDK5	0.96091907
51	PTK2B	0.93918921
52	MAP3K9	0.93447174
53	PLK2	0.89644650
54	CDK14	0.89284255
55	TEC	0.87953062
56	SGK1	0.87331014
57	TLK1	0.86018422
58	BMPR1B	0.84384978
59	PRKCZ	0.84328963
60	CDK15	0.82266995
61	PDK2	0.81256187
62	PRKCQ	0.80927039
63	SGK2	0.80652930
64	CDK11A	0.80167137
65	STK11	0.80133522
66	MAP3K12	0.78157885
67	MAPKAPK5	0.77729755
68	PRKACA	0.73371636
69	CDK18	0.71903042
70	AURKA	0.71223267
71	BCKDK	0.71041739
72	MAP2K4	0.70859381
73	LIMK1	0.69268180
74	MAPK13	0.69067798
75	CSNK1G3	0.68739212
76	OXSR1	0.67600958
77	DYRK1A	0.67042533
78	PRKG1	0.65706706
79	ADRBK1	0.64124020
80	CSNK1A1	0.63646508
81	PRKCA	0.62430492
82	PKN1	0.62273825
83	CSNK2A2	0.62004926
84	ARAF	0.61469255
85	MAPKAPK3	0.60718941
86	ILK	0.60708564
87	RPS6KA3	0.60362812
88	MAPK12	0.60023150
89	PAK1	0.58977405
90	CDK19	0.58225569
91	INSRR	0.57749375
92	MAP3K11	0.56903880
93	PRKCI	0.55590975
94	DAPK3	0.55204568
95	PRKCD	0.54629276
96	CSNK1G1	0.52636060
97	CAMK1G	0.47838477
98	WNK3	0.47625252
99	PRKCH	0.47245488
100	MAPK10	0.46439014

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.73758643
2	Ribosome_Homo sapiens_hsa03010	4.60837502
3	Parkinsons disease_Homo sapiens_hsa05012	3.78282072
4	Nicotine addiction_Homo sapiens_hsa05033	3.53874545
5	Sulfur relay system_Homo sapiens_hsa04122	3.52822433
6	Alzheimers disease_Homo sapiens_hsa05010	3.11024294
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.96755383
8	Huntingtons disease_Homo sapiens_hsa05016	2.48913734
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.44022297
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.21444037
11	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.21421121
12	Morphine addiction_Homo sapiens_hsa05032	1.99859156
13	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.84587435
14	GABAergic synapse_Homo sapiens_hsa04727	1.81314265
15	Insulin secretion_Homo sapiens_hsa04911	1.78932160
16	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.78381561
17	Folate biosynthesis_Homo sapiens_hsa00790	1.67350202
18	Circadian entrainment_Homo sapiens_hsa04713	1.65667552
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.64305246
20	Phototransduction_Homo sapiens_hsa04744	1.53300700
21	Amphetamine addiction_Homo sapiens_hsa05031	1.45983433
22	Long-term potentiation_Homo sapiens_hsa04720	1.42587791
23	Dopaminergic synapse_Homo sapiens_hsa04728	1.41655265
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.37852676
25	Salivary secretion_Homo sapiens_hsa04970	1.33688989
26	RNA polymerase_Homo sapiens_hsa03020	1.31715156
27	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.31494575
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.30001112
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.25972492
30	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.23425732
31	Cocaine addiction_Homo sapiens_hsa05030	1.18627049
32	Gastric acid secretion_Homo sapiens_hsa04971	1.16570362
33	Serotonergic synapse_Homo sapiens_hsa04726	1.15449173
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.13939896
35	Calcium signaling pathway_Homo sapiens_hsa04020	1.12448347
36	Sulfur metabolism_Homo sapiens_hsa00920	1.11861906
37	Cholinergic synapse_Homo sapiens_hsa04725	1.07974409
38	Olfactory transduction_Homo sapiens_hsa04740	1.07871130
39	Taste transduction_Homo sapiens_hsa04742	1.07471856
40	Renin secretion_Homo sapiens_hsa04924	0.99782178
41	Arginine and proline metabolism_Homo sapiens_hsa00330	0.93612614
42	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.90238076
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.88972789
44	Pancreatic secretion_Homo sapiens_hsa04972	0.84941961
45	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.84465240
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83377769
47	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.81693471
48	Mineral absorption_Homo sapiens_hsa04978	0.76258555
49	Protein export_Homo sapiens_hsa03060	0.75880904
50	cAMP signaling pathway_Homo sapiens_hsa04024	0.71830164
51	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.65300843
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64233739
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.63312645
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.60815666
55	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57411949
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55845646
57	Long-term depression_Homo sapiens_hsa04730	0.55761904
58	Homologous recombination_Homo sapiens_hsa03440	0.53040770
59	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.52541085
60	Metabolic pathways_Homo sapiens_hsa01100	0.51395011
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50241961
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49700732
63	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48032026
64	Regulation of autophagy_Homo sapiens_hsa04140	0.47812389
65	Phenylalanine metabolism_Homo sapiens_hsa00360	0.47544501
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46566064
67	Butanoate metabolism_Homo sapiens_hsa00650	0.44375425
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.42865062
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42426605
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41902627
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41831920
72	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.40260397
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.38537822
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37963755
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.37359453
76	Retinol metabolism_Homo sapiens_hsa00830	0.37271751
77	Purine metabolism_Homo sapiens_hsa00230	0.37114714
78	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.36459919
79	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.36382292
80	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.36326233
81	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.35254926
82	Peroxisome_Homo sapiens_hsa04146	0.35019932
83	Asthma_Homo sapiens_hsa05310	0.31603242
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.30844262
85	Rheumatoid arthritis_Homo sapiens_hsa05323	0.30047914
86	Histidine metabolism_Homo sapiens_hsa00340	0.28093927
87	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.25663493
88	Gap junction_Homo sapiens_hsa04540	0.23182620
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.22942595
90	Ras signaling pathway_Homo sapiens_hsa04014	0.20741169
91	Bile secretion_Homo sapiens_hsa04976	0.20380493
92	Melanogenesis_Homo sapiens_hsa04916	0.19432543
93	GnRH signaling pathway_Homo sapiens_hsa04912	0.18287163
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.18249302
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.16976253
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.15957031
97	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.15687547
98	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.15633357
99	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.14994215
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.14789443

MTND1P23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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