MTND1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron fate determination (GO:0048664)9.63819689
2microtubule polymerization or depolymerization (GO:0031109)7.30676007
3mitotic sister chromatid segregation (GO:0000070)6.70506321
4hepatocyte differentiation (GO:0070365)6.57302011
5negative regulation of cell aging (GO:0090344)6.56152854
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.23840350
7sister chromatid segregation (GO:0000819)5.83014216
8spinal cord association neuron differentiation (GO:0021527)5.48066769
9hematopoietic stem cell proliferation (GO:0071425)5.21951558
10positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)5.11339896
11cranial nerve morphogenesis (GO:0021602)5.02543568
12dendritic spine morphogenesis (GO:0060997)4.89975639
13positive regulation of lamellipodium assembly (GO:0010592)4.44629715
14protein depolymerization (GO:0051261)4.44093039
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.24779300
16acrosome assembly (GO:0001675)4.09624115
17secondary metabolite biosynthetic process (GO:0044550)3.99594174
18cullin deneddylation (GO:0010388)3.87882011
19myoblast fusion (GO:0007520)3.87875593
20midbrain development (GO:0030901)3.82698604
21snRNA processing (GO:0016180)3.78268561
22regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.76210455
23kinetochore assembly (GO:0051382)3.73112180
24pyrimidine nucleobase catabolic process (GO:0006208)3.60239034
25axoneme assembly (GO:0035082)3.57405197
26cell differentiation in spinal cord (GO:0021515)3.49867707
27regulation of cofactor metabolic process (GO:0051193)3.44546070
28regulation of coenzyme metabolic process (GO:0051196)3.44546070
29central nervous system projection neuron axonogenesis (GO:0021952)3.41319784
307-methylguanosine mRNA capping (GO:0006370)3.33786066
31response to redox state (GO:0051775)3.33660394
32positive regulation of lamellipodium organization (GO:1902745)3.32110009
33forebrain neuron development (GO:0021884)3.30954549
34positive regulation of embryonic development (GO:0040019)3.29417985
35detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.27513874
36detection of temperature stimulus involved in sensory perception (GO:0050961)3.27513874
37RNA capping (GO:0036260)3.24548034
387-methylguanosine RNA capping (GO:0009452)3.24548034
39protein deneddylation (GO:0000338)3.23997894
40retinal ganglion cell axon guidance (GO:0031290)3.21057144
41base-excision repair, AP site formation (GO:0006285)3.19029337
42regulation of synapse structural plasticity (GO:0051823)3.17739465
43establishment of mitochondrion localization (GO:0051654)3.17582222
44snRNA metabolic process (GO:0016073)3.17329935
45mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.16854122
46positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.16854122
47DNA excision (GO:0044349)3.16450658
48nucleotide-excision repair, DNA damage removal (GO:0000718)3.16450658
49syncytium formation by plasma membrane fusion (GO:0000768)3.16361403
50regulation of acyl-CoA biosynthetic process (GO:0050812)3.16026624
51kinetochore organization (GO:0051383)3.12239877
52regulation of axon regeneration (GO:0048679)3.08486318
53regulation of neuron projection regeneration (GO:0070570)3.08486318
54DNA damage response, detection of DNA damage (GO:0042769)3.07801414
55syncytium formation (GO:0006949)3.03216131
56regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.02680411
57protein complex biogenesis (GO:0070271)2.97284467
58negative regulation of membrane potential (GO:0045837)2.94185870
59regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.94171855
60nucleobase catabolic process (GO:0046113)2.91404652
61embryonic axis specification (GO:0000578)2.87628707
62regulation of glutamate receptor signaling pathway (GO:1900449)2.83262725
63startle response (GO:0001964)2.83148799
64keratinocyte development (GO:0003334)2.82735105
65dendritic spine organization (GO:0097061)2.81546396
66lens morphogenesis in camera-type eye (GO:0002089)2.77703161
67regulation of sulfur metabolic process (GO:0042762)2.77106591
68mitochondrial respiratory chain complex assembly (GO:0033108)2.75695133
69positive regulation of mitochondrial fission (GO:0090141)2.75496798
70sympathetic nervous system development (GO:0048485)2.74801669
71ether lipid metabolic process (GO:0046485)2.71370044
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70980870
73melanin biosynthetic process (GO:0042438)2.67035541
74pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66843848
75regulation of short-term neuronal synaptic plasticity (GO:0048172)2.63257910
76central nervous system neuron axonogenesis (GO:0021955)2.57847683
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55693308
78mitochondrial respiratory chain complex I assembly (GO:0032981)2.55693308
79NADH dehydrogenase complex assembly (GO:0010257)2.55693308
80microtubule severing (GO:0051013)2.51201219
81intraciliary transport (GO:0042073)2.50255746
82protein polyglutamylation (GO:0018095)2.49451602
83negative regulation of systemic arterial blood pressure (GO:0003085)2.47406748
84regulation of transmission of nerve impulse (GO:0051969)2.47256146
85presynaptic membrane organization (GO:0097090)2.41009121
86negative regulation of microtubule polymerization (GO:0031115)2.40351088
87detection of temperature stimulus (GO:0016048)2.39196083
88negative regulation of telomere maintenance (GO:0032205)2.37906967
89cytokinetic process (GO:0032506)2.37877995
90female gonad development (GO:0008585)2.37405410
91pyrimidine nucleotide catabolic process (GO:0006244)2.37158294
92melanin metabolic process (GO:0006582)2.36658216
93regulation of protein kinase A signaling (GO:0010738)2.35624951
94protein-cofactor linkage (GO:0018065)2.35083094
95regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.34579994
96microtubule bundle formation (GO:0001578)2.33697600
97positive regulation of Notch signaling pathway (GO:0045747)2.31692292
98cellular response to nicotine (GO:0071316)2.31280304
99regulation of feeding behavior (GO:0060259)2.29841355
100microtubule depolymerization (GO:0007019)12.0707092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.35376202
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.45002118
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.16215835
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.14615807
5GBX2_23144817_ChIP-Seq_PC3_Human3.08549105
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83399841
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78410076
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78212657
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70900280
10EZH2_22144423_ChIP-Seq_EOC_Human2.70533487
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57942249
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39184471
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.33019973
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11627834
15ZNF274_21170338_ChIP-Seq_K562_Hela2.11030507
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10299530
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05543124
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02949285
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02229583
20RNF2_27304074_Chip-Seq_NSC_Mouse1.95420573
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91731134
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.90114886
23TAF15_26573619_Chip-Seq_HEK293_Human1.82690787
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79814994
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.79276192
26EWS_26573619_Chip-Seq_HEK293_Human1.67050754
27P300_19829295_ChIP-Seq_ESCs_Human1.64975076
28GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.59086842
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50151086
30VDR_22108803_ChIP-Seq_LS180_Human1.47502942
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.46409591
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46136331
33CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45579768
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.45011707
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.43302137
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43176638
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43057357
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.42507508
39JUN_21703547_ChIP-Seq_K562_Human1.42487130
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.39831176
41P53_22387025_ChIP-Seq_ESCs_Mouse1.37981998
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36970001
43FUS_26573619_Chip-Seq_HEK293_Human1.35193885
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33934246
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33441458
46ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33137002
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33009215
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30721781
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30455399
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29319607
51REST_21632747_ChIP-Seq_MESCs_Mouse1.29139262
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28609670
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28522640
54TP53_22573176_ChIP-Seq_HFKS_Human1.27269678
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27063160
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25693940
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24823023
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22634357
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.22410505
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16586742
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.15926833
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15028450
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13456976
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13456976
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13456976
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13125701
67TCF4_23295773_ChIP-Seq_U87_Human1.13080601
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12555722
69SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11881531
70TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11337562
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10618754
72STAT3_23295773_ChIP-Seq_U87_Human1.10552353
73AR_25329375_ChIP-Seq_VCAP_Human1.09906023
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.09803294
75TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09798160
76FOXP3_21729870_ChIP-Seq_TREG_Human1.08912109
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.07754947
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07639734
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.06563845
80MYC_18940864_ChIP-ChIP_HL60_Human1.06209986
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04174474
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01719923
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01139007
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01139007
85VDR_23849224_ChIP-Seq_CD4+_Human1.00776184
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00206582
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.00065948
88SMAD3_21741376_ChIP-Seq_EPCs_Human0.99979867
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99916118
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99611733
91TCF4_22108803_ChIP-Seq_LS180_Human0.99586298
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99533759
93E2F1_18555785_Chip-Seq_ESCs_Mouse0.99514059
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99452919
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.98531120
96RBPJ_21746931_ChIP-Seq_IB4_Human0.98339905
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97499115
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.96772459
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95606187
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.94767780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.46864542
2MP0004142_abnormal_muscle_tone4.50510139
3MP0004742_abnormal_vestibular_system4.15083176
4MP0005171_absent_coat_pigmentation4.07950718
5MP0003787_abnormal_imprinting3.41967437
6MP0000372_irregular_coat_pigmentation3.39306735
7MP0002938_white_spotting3.23441167
8MP0003122_maternal_imprinting3.11417405
9MP0008058_abnormal_DNA_repair3.10484473
10MP0004510_myositis2.78976980
11MP0008877_abnormal_DNA_methylation2.70439654
12MP0001188_hyperpigmentation2.60705621
13MP0003121_genomic_imprinting2.43823195
14MP0002249_abnormal_larynx_morphology2.41696012
15MP0006276_abnormal_autonomic_nervous2.00916545
16MP0005174_abnormal_tail_pigmentation1.96464631
17MP0003195_calcinosis1.88383429
18MP0005084_abnormal_gallbladder_morpholo1.85288330
19MP0003806_abnormal_nucleotide_metabolis1.83742598
20MP0009697_abnormal_copulation1.76737941
21MP0002095_abnormal_skin_pigmentation1.71213178
22MP0005253_abnormal_eye_physiology1.68489307
23MP0000049_abnormal_middle_ear1.67923816
24MP0000778_abnormal_nervous_system1.65347807
25MP0005551_abnormal_eye_electrophysiolog1.64077190
26MP0004133_heterotaxia1.59738216
27MP0005187_abnormal_penis_morphology1.58279604
28MP0009046_muscle_twitch1.56430973
29MP0001486_abnormal_startle_reflex1.47603528
30MP0004215_abnormal_myocardial_fiber1.44552925
31MP0001873_stomach_inflammation1.40907538
32MP0005248_abnormal_Harderian_gland1.29817152
33MP0002138_abnormal_hepatobiliary_system1.27504957
34MP0005409_darkened_coat_color1.26755501
35MP0006292_abnormal_olfactory_placode1.26061415
36MP0006035_abnormal_mitochondrial_morpho1.25544137
37MP0002090_abnormal_vision1.20740723
38MP0002557_abnormal_social/conspecific_i1.17801262
39MP0000015_abnormal_ear_pigmentation1.15103861
40MP0005167_abnormal_blood-brain_barrier1.11877516
41MP0010386_abnormal_urinary_bladder1.10674635
42MP0002184_abnormal_innervation1.09834173
43MP0002067_abnormal_sensory_capabilities1.07741810
44MP0002272_abnormal_nervous_system1.07425453
45MP0001324_abnormal_eye_pigmentation1.05785719
46MP0000026_abnormal_inner_ear1.05344336
47MP0003890_abnormal_embryonic-extraembry1.03125419
48MP0002638_abnormal_pupillary_reflex1.01885496
49MP0001986_abnormal_taste_sensitivity1.01039440
50MP0004924_abnormal_behavior1.00689886
51MP0005386_behavior/neurological_phenoty1.00689886
52MP0002063_abnormal_learning/memory/cond1.00461997
53MP0005083_abnormal_biliary_tract0.99191169
54MP0002332_abnormal_exercise_endurance0.98835381
55MP0008932_abnormal_embryonic_tissue0.98675850
56MP0003123_paternal_imprinting0.98656956
57MP0005410_abnormal_fertilization0.96670045
58MP0003077_abnormal_cell_cycle0.95697626
59MP0003868_abnormal_feces_composition0.94731650
60MP0002752_abnormal_somatic_nervous0.93198327
61MP0003693_abnormal_embryo_hatching0.92704779
62MP0003879_abnormal_hair_cell0.91044301
63MP0009745_abnormal_behavioral_response0.90918002
64MP0003880_abnormal_central_pattern0.89305135
65MP0002653_abnormal_ependyma_morphology0.88921270
66MP0005391_vision/eye_phenotype0.88907270
67MP0000955_abnormal_spinal_cord0.87942413
68MP0001879_abnormal_lymphatic_vessel0.87677765
69MP0001293_anophthalmia0.87350083
70MP0004859_abnormal_synaptic_plasticity0.86370451
71MP0002733_abnormal_thermal_nociception0.83705154
72MP0000569_abnormal_digit_pigmentation0.83533471
73MP0006082_CNS_inflammation0.82945277
74MP0003119_abnormal_digestive_system0.82643648
75MP0003635_abnormal_synaptic_transmissio0.81734250
76MP0003937_abnormal_limbs/digits/tail_de0.80457762
77MP0001502_abnormal_circadian_rhythm0.79500501
78MP0001485_abnormal_pinna_reflex0.78423191
79MP0000537_abnormal_urethra_morphology0.78297689
80MP0001970_abnormal_pain_threshold0.78241942
81MP0002751_abnormal_autonomic_nervous0.76786521
82MP0003938_abnormal_ear_development0.76729612
83MP0001905_abnormal_dopamine_level0.76140400
84MP0002127_abnormal_cardiovascular_syste0.74424045
85MP0003186_abnormal_redox_activity0.71829356
86MP0002229_neurodegeneration0.71686150
87MP0002572_abnormal_emotion/affect_behav0.71084910
88MP0000358_abnormal_cell_content/0.70118751
89MP0002177_abnormal_outer_ear0.69518891
90MP0002697_abnormal_eye_size0.68025026
91MP0006072_abnormal_retinal_apoptosis0.67125308
92MP0002152_abnormal_brain_morphology0.66951956
93MP0001968_abnormal_touch/_nociception0.66915927
94MP0002882_abnormal_neuron_morphology0.66273058
95MP0006054_spinal_hemorrhage0.66229100
96MP0003137_abnormal_impulse_conducting0.64315713
97MP0003861_abnormal_nervous_system0.64205098
98MP0000013_abnormal_adipose_tissue0.63065181
99MP0002837_dystrophic_cardiac_calcinosis0.62673116
100MP0000465_gastrointestinal_hemorrhage0.62340364

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the pons (HP:0012110)8.26505998
2Abnormality of the pons (HP:0007361)7.33858091
3Hypoplastic pelvis (HP:0008839)4.66174730
4Neonatal respiratory distress (HP:0002643)4.27913401
5Abnormality of abdominal situs (HP:0011620)4.25373809
6Abdominal situs inversus (HP:0003363)4.25373809
7Abnormality of the labia minora (HP:0012880)4.08587608
8Entropion (HP:0000621)3.91291647
9Poikiloderma (HP:0001029)3.87782123
10Supernumerary spleens (HP:0009799)3.35746270
11High anterior hairline (HP:0009890)3.35221821
12Molar tooth sign on MRI (HP:0002419)3.27672866
13Abnormality of midbrain morphology (HP:0002418)3.27672866
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17921710
15Abnormality of alanine metabolism (HP:0010916)3.17921710
16Hyperalaninemia (HP:0003348)3.17921710
17Abnormality of DNA repair (HP:0003254)2.90287896
18Thin ribs (HP:0000883)2.89220663
19Amniotic constriction ring (HP:0009775)2.86664014
20Abnormality of placental membranes (HP:0011409)2.86664014
21Oligomenorrhea (HP:0000876)2.78605048
22Adactyly (HP:0009776)2.77336405
23Retinal dysplasia (HP:0007973)2.68736399
24Increased intramyocellular lipid droplets (HP:0012240)2.63648579
25Aplasia/Hypoplasia of the spleen (HP:0010451)2.54446757
26Abnormality of lateral ventricle (HP:0030047)2.49267425
27Focal motor seizures (HP:0011153)2.49234250
28Asplenia (HP:0001746)2.48625601
29Decreased lacrimation (HP:0000633)2.47835211
30Increased hepatocellular lipid droplets (HP:0006565)2.45688221
31Bifid tongue (HP:0010297)2.43968564
32Aplasia/hypoplasia of the uterus (HP:0008684)2.42936233
33Poor suck (HP:0002033)2.37859577
34Sensory axonal neuropathy (HP:0003390)2.36260342
35Cerebellar dysplasia (HP:0007033)2.35594250
36Generalized aminoaciduria (HP:0002909)2.35519541
37Lipid accumulation in hepatocytes (HP:0006561)2.34230640
38Aplasia of the musculature (HP:0100854)2.33497556
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.30844943
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28442011
41Hepatoblastoma (HP:0002884)2.28429283
42Oligodactyly (hands) (HP:0001180)2.21165039
43Popliteal pterygium (HP:0009756)2.18160989
44Polyphagia (HP:0002591)2.17817180
45Aplasia/Hypoplasia involving the musculature (HP:0001460)2.16673939
46Increased muscle lipid content (HP:0009058)2.16220474
47Hypoplasia of the uterus (HP:0000013)2.12603989
48Short tibia (HP:0005736)2.10629885
49Generalized hypotonia (HP:0001290)2.09568497
50Fibular aplasia (HP:0002990)2.03531385
51Abnormality of chromosome stability (HP:0003220)2.02915405
52Abnormal auditory evoked potentials (HP:0006958)2.01523971
53Rib fusion (HP:0000902)1.98697243
54Septo-optic dysplasia (HP:0100842)1.92461724
55Abnormality of the labia (HP:0000058)1.91859134
56Dry hair (HP:0011359)1.91386353
57Overriding aorta (HP:0002623)1.90762745
58Aplasia involving forearm bones (HP:0009822)1.89673563
59Absent forearm bone (HP:0003953)1.89673563
60Congenital stationary night blindness (HP:0007642)1.89629216
61Absent septum pellucidum (HP:0001331)1.88902953
62Constricted visual fields (HP:0001133)1.88902794
63Myelomeningocele (HP:0002475)1.88735985
64Keratitis (HP:0000491)1.88360690
65Pendular nystagmus (HP:0012043)1.88151590
66Chromsome breakage (HP:0040012)1.88085706
67Renal cortical cysts (HP:0000803)1.86877087
68Specific learning disability (HP:0001328)1.86400333
69Myokymia (HP:0002411)1.86118273
70Narrow nasal bridge (HP:0000446)1.86080550
71Aplasia/hypoplasia of the humerus (HP:0006507)1.85183085
72Labial hypoplasia (HP:0000066)1.83167554
73Pachygyria (HP:0001302)1.81524570
74Short humerus (HP:0005792)1.81167008
75Renal Fanconi syndrome (HP:0001994)1.80159682
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79992798
77Poor head control (HP:0002421)1.76474530
78Hypoplastic female external genitalia (HP:0012815)1.75878758
79Scrotal hypoplasia (HP:0000046)1.75732466
80Hepatic necrosis (HP:0002605)1.74669462
81Abnormality of magnesium homeostasis (HP:0004921)1.73697075
82Hypoplastic iliac wings (HP:0002866)1.72544235
83Metaphyseal dysplasia (HP:0100255)1.71750494
84Congenital sensorineural hearing impairment (HP:0008527)1.71488918
85Visual hallucinations (HP:0002367)1.71440229
86Type II lissencephaly (HP:0007260)1.70497950
87Meningocele (HP:0002435)1.70407330
88Intestinal atresia (HP:0011100)1.68026504
89Hepatocellular necrosis (HP:0001404)1.67370918
90Dialeptic seizures (HP:0011146)1.67232212
91Brushfield spots (HP:0001088)1.67020526
92Generalized tonic-clonic seizures (HP:0002069)1.66668691
93Patellar aplasia (HP:0006443)1.66610267
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.65220595
95Abolished electroretinogram (ERG) (HP:0000550)1.64599055
96Abnormality of the septum pellucidum (HP:0007375)1.64280244
97Optic nerve hypoplasia (HP:0000609)1.62863229
98Neoplasm of the adrenal cortex (HP:0100641)1.61626574
99Epileptic encephalopathy (HP:0200134)1.60430378
100Lissencephaly (HP:0001339)1.56934145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.21462944
2GRK72.94564230
3BUB12.93625440
4BCR2.34124670
5WNK42.04232214
6KIT2.02891855
7STK1611.0967698
8MST41.85156236
9CCNB11.78088097
10WNK31.64900019
11NUAK11.52973004
12DYRK31.49727357
13PAK61.36892701
14MARK11.32574382
15CDC71.30640208
16UHMK11.29623848
17MAP2K71.28880739
18CSNK1G31.26280384
19MAP4K21.21298106
20PDK21.20041836
21DMPK1.16694707
22CSNK1A1L1.15137987
23PLK31.14445185
24FRK1.14383949
25TSSK61.11738576
26MAP3K41.02177826
27CSNK1G21.01260565
28PNCK0.99854553
29MAPK130.99652736
30WEE10.95740281
31CSNK1G10.95684848
32NEK20.95185519
33PLK40.92931429
34NEK10.90825700
35PBK0.89385884
36BCKDK0.88348473
37MINK10.85690148
38PLK20.85454081
39TRIM280.82839286
40PAK30.79619837
41MAP3K120.79264796
42DAPK20.76340203
43VRK10.74969657
44PLK10.71932348
45STK240.69498806
46ERBB20.67579530
47EIF2AK10.66444462
48GRK50.66249373
49RAF10.65747148
50PINK10.63934084
51SIK30.63612566
52MAP3K110.59832922
53CDK30.57962384
54PRKACB0.55790395
55CDK190.54750089
56ADRBK10.54234592
57NTRK10.53984086
58EPHB20.53119909
59MKNK20.52312528
60EPHA40.51777131
61CSNK1A10.51670190
62ATR0.50091513
63NTRK30.49532001
64TIE10.49486056
65PRKG10.48791487
66BRSK20.48374578
67MATK0.44837630
68AKT20.44776148
69LIMK10.44428692
70GRK10.43737969
71PRKCQ0.43612048
72CSNK1E0.41626227
73ATM0.41022721
74MKNK10.40887328
75SRPK10.39977616
76PAK10.38701263
77BRSK10.38100202
78ADRBK20.37214464
79BRD40.37037530
80PIM20.36756528
81TTK0.36571300
82STK390.35297837
83ACVR1B0.35210617
84ZAK0.34411471
85EGFR0.34344724
86DYRK20.34083825
87AURKA0.31949838
88PKN10.31557429
89MAPK140.30141027
90PRKACA0.28813626
91EPHA30.28636222
92AURKB0.27139587
93EIF2AK30.26965576
94CDK140.25787520
95MAP2K40.25700056
96MOS0.25573706
97NME10.25519464
98MARK30.25450740
99CDK180.24837063
100SIK20.23081413

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.15844282
2Basal transcription factors_Homo sapiens_hsa030223.45484254
3Steroid biosynthesis_Homo sapiens_hsa001002.82369054
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.73118657
5Nucleotide excision repair_Homo sapiens_hsa034202.61126377
6Protein export_Homo sapiens_hsa030602.47802468
7Butanoate metabolism_Homo sapiens_hsa006502.45285769
8Homologous recombination_Homo sapiens_hsa034402.43664895
9Phototransduction_Homo sapiens_hsa047442.37624823
10Base excision repair_Homo sapiens_hsa034102.29303082
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28201002
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04092220
13Folate biosynthesis_Homo sapiens_hsa007902.02605738
14Olfactory transduction_Homo sapiens_hsa047401.91580863
15Basal cell carcinoma_Homo sapiens_hsa052171.83467701
16Parkinsons disease_Homo sapiens_hsa050121.77565041
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75543823
18Hippo signaling pathway_Homo sapiens_hsa043901.68366740
19Hedgehog signaling pathway_Homo sapiens_hsa043401.62878757
20Sulfur relay system_Homo sapiens_hsa041221.62654419
21Nicotine addiction_Homo sapiens_hsa050331.62641847
22Non-homologous end-joining_Homo sapiens_hsa034501.52805518
23Fanconi anemia pathway_Homo sapiens_hsa034601.52058914
24Melanogenesis_Homo sapiens_hsa049161.49909715
25Proteasome_Homo sapiens_hsa030501.44807919
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33173307
27Oxidative phosphorylation_Homo sapiens_hsa001901.32922908
28Propanoate metabolism_Homo sapiens_hsa006401.19450000
29beta-Alanine metabolism_Homo sapiens_hsa004101.18634007
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.18602077
31Tight junction_Homo sapiens_hsa045301.16940277
32Selenocompound metabolism_Homo sapiens_hsa004501.12935619
33Huntingtons disease_Homo sapiens_hsa050161.12029941
34Mismatch repair_Homo sapiens_hsa034301.09179003
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06612484
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05835039
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05760175
38Morphine addiction_Homo sapiens_hsa050321.05634822
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03281956
40Linoleic acid metabolism_Homo sapiens_hsa005910.98319709
41Oocyte meiosis_Homo sapiens_hsa041140.93582113
42Wnt signaling pathway_Homo sapiens_hsa043100.91953807
43Ether lipid metabolism_Homo sapiens_hsa005650.91724829
44Glutathione metabolism_Homo sapiens_hsa004800.90662851
45Alzheimers disease_Homo sapiens_hsa050100.87442306
46GABAergic synapse_Homo sapiens_hsa047270.86229914
47Regulation of autophagy_Homo sapiens_hsa041400.85307849
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85048196
49mRNA surveillance pathway_Homo sapiens_hsa030150.84160116
50DNA replication_Homo sapiens_hsa030300.82734475
51Tryptophan metabolism_Homo sapiens_hsa003800.80162601
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79704500
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78247824
54Spliceosome_Homo sapiens_hsa030400.76774231
55Arginine and proline metabolism_Homo sapiens_hsa003300.76727028
56Pyruvate metabolism_Homo sapiens_hsa006200.72307351
57RNA degradation_Homo sapiens_hsa030180.70861532
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69413343
59Taste transduction_Homo sapiens_hsa047420.69281764
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68190116
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67594697
62Purine metabolism_Homo sapiens_hsa002300.67562053
63Circadian entrainment_Homo sapiens_hsa047130.65610659
64Axon guidance_Homo sapiens_hsa043600.65396886
65RNA transport_Homo sapiens_hsa030130.64650619
66Cell cycle_Homo sapiens_hsa041100.63989727
67Pyrimidine metabolism_Homo sapiens_hsa002400.63407830
68Renin secretion_Homo sapiens_hsa049240.60806618
69ABC transporters_Homo sapiens_hsa020100.59881989
70RNA polymerase_Homo sapiens_hsa030200.59362364
71Cardiac muscle contraction_Homo sapiens_hsa042600.58098730
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56805203
73p53 signaling pathway_Homo sapiens_hsa041150.56212826
74Peroxisome_Homo sapiens_hsa041460.55740617
75Chemical carcinogenesis_Homo sapiens_hsa052040.52723276
76Fatty acid degradation_Homo sapiens_hsa000710.52531510
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51577954
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51558291
79Glutamatergic synapse_Homo sapiens_hsa047240.50498060
80Sulfur metabolism_Homo sapiens_hsa009200.50357013
81Retinol metabolism_Homo sapiens_hsa008300.47515295
82Synaptic vesicle cycle_Homo sapiens_hsa047210.47146234
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46180097
84Metabolic pathways_Homo sapiens_hsa011000.46043078
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45537090
86Adherens junction_Homo sapiens_hsa045200.45355631
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44085536
88Long-term depression_Homo sapiens_hsa047300.43037438
89Dopaminergic synapse_Homo sapiens_hsa047280.42949664
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41653808
91Salivary secretion_Homo sapiens_hsa049700.41583143
92TGF-beta signaling pathway_Homo sapiens_hsa043500.41325401
93Ribosome_Homo sapiens_hsa030100.36574003
94Tyrosine metabolism_Homo sapiens_hsa003500.35629445
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.32448845
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30860814
97Insulin secretion_Homo sapiens_hsa049110.30349564
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30132982
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.29843247
100Caffeine metabolism_Homo sapiens_hsa002320.27885712

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