

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neuron fate determination (GO:0048664) | 9.63819689 |
| 2 | microtubule polymerization or depolymerization (GO:0031109) | 7.30676007 |
| 3 | mitotic sister chromatid segregation (GO:0000070) | 6.70506321 |
| 4 | hepatocyte differentiation (GO:0070365) | 6.57302011 |
| 5 | negative regulation of cell aging (GO:0090344) | 6.56152854 |
| 6 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 6.23840350 |
| 7 | sister chromatid segregation (GO:0000819) | 5.83014216 |
| 8 | spinal cord association neuron differentiation (GO:0021527) | 5.48066769 |
| 9 | hematopoietic stem cell proliferation (GO:0071425) | 5.21951558 |
| 10 | positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568) | 5.11339896 |
| 11 | cranial nerve morphogenesis (GO:0021602) | 5.02543568 |
| 12 | dendritic spine morphogenesis (GO:0060997) | 4.89975639 |
| 13 | positive regulation of lamellipodium assembly (GO:0010592) | 4.44629715 |
| 14 | protein depolymerization (GO:0051261) | 4.44093039 |
| 15 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.24779300 |
| 16 | acrosome assembly (GO:0001675) | 4.09624115 |
| 17 | secondary metabolite biosynthetic process (GO:0044550) | 3.99594174 |
| 18 | cullin deneddylation (GO:0010388) | 3.87882011 |
| 19 | myoblast fusion (GO:0007520) | 3.87875593 |
| 20 | midbrain development (GO:0030901) | 3.82698604 |
| 21 | snRNA processing (GO:0016180) | 3.78268561 |
| 22 | regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2 | 3.76210455 |
| 23 | kinetochore assembly (GO:0051382) | 3.73112180 |
| 24 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.60239034 |
| 25 | axoneme assembly (GO:0035082) | 3.57405197 |
| 26 | cell differentiation in spinal cord (GO:0021515) | 3.49867707 |
| 27 | regulation of cofactor metabolic process (GO:0051193) | 3.44546070 |
| 28 | regulation of coenzyme metabolic process (GO:0051196) | 3.44546070 |
| 29 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.41319784 |
| 30 | 7-methylguanosine mRNA capping (GO:0006370) | 3.33786066 |
| 31 | response to redox state (GO:0051775) | 3.33660394 |
| 32 | positive regulation of lamellipodium organization (GO:1902745) | 3.32110009 |
| 33 | forebrain neuron development (GO:0021884) | 3.30954549 |
| 34 | positive regulation of embryonic development (GO:0040019) | 3.29417985 |
| 35 | detection of temperature stimulus involved in sensory perception of pain (GO:0050965) | 3.27513874 |
| 36 | detection of temperature stimulus involved in sensory perception (GO:0050961) | 3.27513874 |
| 37 | RNA capping (GO:0036260) | 3.24548034 |
| 38 | 7-methylguanosine RNA capping (GO:0009452) | 3.24548034 |
| 39 | protein deneddylation (GO:0000338) | 3.23997894 |
| 40 | retinal ganglion cell axon guidance (GO:0031290) | 3.21057144 |
| 41 | base-excision repair, AP site formation (GO:0006285) | 3.19029337 |
| 42 | regulation of synapse structural plasticity (GO:0051823) | 3.17739465 |
| 43 | establishment of mitochondrion localization (GO:0051654) | 3.17582222 |
| 44 | snRNA metabolic process (GO:0016073) | 3.17329935 |
| 45 | mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686) | 3.16854122 |
| 46 | positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110 | 3.16854122 |
| 47 | DNA excision (GO:0044349) | 3.16450658 |
| 48 | nucleotide-excision repair, DNA damage removal (GO:0000718) | 3.16450658 |
| 49 | syncytium formation by plasma membrane fusion (GO:0000768) | 3.16361403 |
| 50 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.16026624 |
| 51 | kinetochore organization (GO:0051383) | 3.12239877 |
| 52 | regulation of axon regeneration (GO:0048679) | 3.08486318 |
| 53 | regulation of neuron projection regeneration (GO:0070570) | 3.08486318 |
| 54 | DNA damage response, detection of DNA damage (GO:0042769) | 3.07801414 |
| 55 | syncytium formation (GO:0006949) | 3.03216131 |
| 56 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.02680411 |
| 57 | protein complex biogenesis (GO:0070271) | 2.97284467 |
| 58 | negative regulation of membrane potential (GO:0045837) | 2.94185870 |
| 59 | regulation of insulin-like growth factor receptor signaling pathway (GO:0043567) | 2.94171855 |
| 60 | nucleobase catabolic process (GO:0046113) | 2.91404652 |
| 61 | embryonic axis specification (GO:0000578) | 2.87628707 |
| 62 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.83262725 |
| 63 | startle response (GO:0001964) | 2.83148799 |
| 64 | keratinocyte development (GO:0003334) | 2.82735105 |
| 65 | dendritic spine organization (GO:0097061) | 2.81546396 |
| 66 | lens morphogenesis in camera-type eye (GO:0002089) | 2.77703161 |
| 67 | regulation of sulfur metabolic process (GO:0042762) | 2.77106591 |
| 68 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.75695133 |
| 69 | positive regulation of mitochondrial fission (GO:0090141) | 2.75496798 |
| 70 | sympathetic nervous system development (GO:0048485) | 2.74801669 |
| 71 | ether lipid metabolic process (GO:0046485) | 2.71370044 |
| 72 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.70980870 |
| 73 | melanin biosynthetic process (GO:0042438) | 2.67035541 |
| 74 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.66843848 |
| 75 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 2.63257910 |
| 76 | central nervous system neuron axonogenesis (GO:0021955) | 2.57847683 |
| 77 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.55693308 |
| 78 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.55693308 |
| 79 | NADH dehydrogenase complex assembly (GO:0010257) | 2.55693308 |
| 80 | microtubule severing (GO:0051013) | 2.51201219 |
| 81 | intraciliary transport (GO:0042073) | 2.50255746 |
| 82 | protein polyglutamylation (GO:0018095) | 2.49451602 |
| 83 | negative regulation of systemic arterial blood pressure (GO:0003085) | 2.47406748 |
| 84 | regulation of transmission of nerve impulse (GO:0051969) | 2.47256146 |
| 85 | presynaptic membrane organization (GO:0097090) | 2.41009121 |
| 86 | negative regulation of microtubule polymerization (GO:0031115) | 2.40351088 |
| 87 | detection of temperature stimulus (GO:0016048) | 2.39196083 |
| 88 | negative regulation of telomere maintenance (GO:0032205) | 2.37906967 |
| 89 | cytokinetic process (GO:0032506) | 2.37877995 |
| 90 | female gonad development (GO:0008585) | 2.37405410 |
| 91 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.37158294 |
| 92 | melanin metabolic process (GO:0006582) | 2.36658216 |
| 93 | regulation of protein kinase A signaling (GO:0010738) | 2.35624951 |
| 94 | protein-cofactor linkage (GO:0018065) | 2.35083094 |
| 95 | regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178) | 2.34579994 |
| 96 | microtubule bundle formation (GO:0001578) | 2.33697600 |
| 97 | positive regulation of Notch signaling pathway (GO:0045747) | 2.31692292 |
| 98 | cellular response to nicotine (GO:0071316) | 2.31280304 |
| 99 | regulation of feeding behavior (GO:0060259) | 2.29841355 |
| 100 | microtubule depolymerization (GO:0007019) | 12.0707092 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.35376202 |
| 2 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 3.45002118 |
| 3 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.16215835 |
| 4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.14615807 |
| 5 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.08549105 |
| 6 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.83399841 |
| 7 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.78410076 |
| 8 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.78212657 |
| 9 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.70900280 |
| 10 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.70533487 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.57942249 |
| 12 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.39184471 |
| 13 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 2.33019973 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.11627834 |
| 15 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.11030507 |
| 16 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.10299530 |
| 17 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.05543124 |
| 18 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.02949285 |
| 19 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.02229583 |
| 20 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.95420573 |
| 21 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.91731134 |
| 22 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.90114886 |
| 23 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.82690787 |
| 24 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.79814994 |
| 25 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.79276192 |
| 26 | EWS_26573619_Chip-Seq_HEK293_Human | 1.67050754 |
| 27 | P300_19829295_ChIP-Seq_ESCs_Human | 1.64975076 |
| 28 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.59086842 |
| 29 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.50151086 |
| 30 | VDR_22108803_ChIP-Seq_LS180_Human | 1.47502942 |
| 31 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.46409591 |
| 32 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.46136331 |
| 33 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.45579768 |
| 34 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.45011707 |
| 35 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.43302137 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.43176638 |
| 37 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.43057357 |
| 38 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.42507508 |
| 39 | JUN_21703547_ChIP-Seq_K562_Human | 1.42487130 |
| 40 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.39831176 |
| 41 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.37981998 |
| 42 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.36970001 |
| 43 | FUS_26573619_Chip-Seq_HEK293_Human | 1.35193885 |
| 44 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.33934246 |
| 45 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.33441458 |
| 46 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 1.33137002 |
| 47 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.33009215 |
| 48 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.30721781 |
| 49 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.30455399 |
| 50 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.29319607 |
| 51 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.29139262 |
| 52 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.28609670 |
| 53 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.28522640 |
| 54 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.27269678 |
| 55 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.27063160 |
| 56 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.25693940 |
| 57 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.24823023 |
| 58 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.22634357 |
| 59 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.22410505 |
| 60 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.16586742 |
| 61 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.15926833 |
| 62 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.15028450 |
| 63 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.13456976 |
| 64 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.13456976 |
| 65 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.13456976 |
| 66 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.13125701 |
| 67 | TCF4_23295773_ChIP-Seq_U87_Human | 1.13080601 |
| 68 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.12555722 |
| 69 | SOX9_26525672_Chip-Seq_Limbbuds_Mouse | 1.11881531 |
| 70 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 1.11337562 |
| 71 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.10618754 |
| 72 | STAT3_23295773_ChIP-Seq_U87_Human | 1.10552353 |
| 73 | AR_25329375_ChIP-Seq_VCAP_Human | 1.09906023 |
| 74 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.09803294 |
| 75 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 1.09798160 |
| 76 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.08912109 |
| 77 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.07754947 |
| 78 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.07639734 |
| 79 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.06563845 |
| 80 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.06209986 |
| 81 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.04174474 |
| 82 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.01719923 |
| 83 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.01139007 |
| 84 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01139007 |
| 85 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.00776184 |
| 86 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.00206582 |
| 87 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.00065948 |
| 88 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.99979867 |
| 89 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.99916118 |
| 90 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.99611733 |
| 91 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.99586298 |
| 92 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.99533759 |
| 93 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.99514059 |
| 94 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.99452919 |
| 95 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.98531120 |
| 96 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.98339905 |
| 97 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.97499115 |
| 98 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.96772459 |
| 99 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.95606187 |
| 100 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.94767780 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003136_yellow_coat_color | 5.46864542 |
| 2 | MP0004142_abnormal_muscle_tone | 4.50510139 |
| 3 | MP0004742_abnormal_vestibular_system | 4.15083176 |
| 4 | MP0005171_absent_coat_pigmentation | 4.07950718 |
| 5 | MP0003787_abnormal_imprinting | 3.41967437 |
| 6 | MP0000372_irregular_coat_pigmentation | 3.39306735 |
| 7 | MP0002938_white_spotting | 3.23441167 |
| 8 | MP0003122_maternal_imprinting | 3.11417405 |
| 9 | MP0008058_abnormal_DNA_repair | 3.10484473 |
| 10 | MP0004510_myositis | 2.78976980 |
| 11 | MP0008877_abnormal_DNA_methylation | 2.70439654 |
| 12 | MP0001188_hyperpigmentation | 2.60705621 |
| 13 | MP0003121_genomic_imprinting | 2.43823195 |
| 14 | MP0002249_abnormal_larynx_morphology | 2.41696012 |
| 15 | MP0006276_abnormal_autonomic_nervous | 2.00916545 |
| 16 | MP0005174_abnormal_tail_pigmentation | 1.96464631 |
| 17 | MP0003195_calcinosis | 1.88383429 |
| 18 | MP0005084_abnormal_gallbladder_morpholo | 1.85288330 |
| 19 | MP0003806_abnormal_nucleotide_metabolis | 1.83742598 |
| 20 | MP0009697_abnormal_copulation | 1.76737941 |
| 21 | MP0002095_abnormal_skin_pigmentation | 1.71213178 |
| 22 | MP0005253_abnormal_eye_physiology | 1.68489307 |
| 23 | MP0000049_abnormal_middle_ear | 1.67923816 |
| 24 | MP0000778_abnormal_nervous_system | 1.65347807 |
| 25 | MP0005551_abnormal_eye_electrophysiolog | 1.64077190 |
| 26 | MP0004133_heterotaxia | 1.59738216 |
| 27 | MP0005187_abnormal_penis_morphology | 1.58279604 |
| 28 | MP0009046_muscle_twitch | 1.56430973 |
| 29 | MP0001486_abnormal_startle_reflex | 1.47603528 |
| 30 | MP0004215_abnormal_myocardial_fiber | 1.44552925 |
| 31 | MP0001873_stomach_inflammation | 1.40907538 |
| 32 | MP0005248_abnormal_Harderian_gland | 1.29817152 |
| 33 | MP0002138_abnormal_hepatobiliary_system | 1.27504957 |
| 34 | MP0005409_darkened_coat_color | 1.26755501 |
| 35 | MP0006292_abnormal_olfactory_placode | 1.26061415 |
| 36 | MP0006035_abnormal_mitochondrial_morpho | 1.25544137 |
| 37 | MP0002090_abnormal_vision | 1.20740723 |
| 38 | MP0002557_abnormal_social/conspecific_i | 1.17801262 |
| 39 | MP0000015_abnormal_ear_pigmentation | 1.15103861 |
| 40 | MP0005167_abnormal_blood-brain_barrier | 1.11877516 |
| 41 | MP0010386_abnormal_urinary_bladder | 1.10674635 |
| 42 | MP0002184_abnormal_innervation | 1.09834173 |
| 43 | MP0002067_abnormal_sensory_capabilities | 1.07741810 |
| 44 | MP0002272_abnormal_nervous_system | 1.07425453 |
| 45 | MP0001324_abnormal_eye_pigmentation | 1.05785719 |
| 46 | MP0000026_abnormal_inner_ear | 1.05344336 |
| 47 | MP0003890_abnormal_embryonic-extraembry | 1.03125419 |
| 48 | MP0002638_abnormal_pupillary_reflex | 1.01885496 |
| 49 | MP0001986_abnormal_taste_sensitivity | 1.01039440 |
| 50 | MP0004924_abnormal_behavior | 1.00689886 |
| 51 | MP0005386_behavior/neurological_phenoty | 1.00689886 |
| 52 | MP0002063_abnormal_learning/memory/cond | 1.00461997 |
| 53 | MP0005083_abnormal_biliary_tract | 0.99191169 |
| 54 | MP0002332_abnormal_exercise_endurance | 0.98835381 |
| 55 | MP0008932_abnormal_embryonic_tissue | 0.98675850 |
| 56 | MP0003123_paternal_imprinting | 0.98656956 |
| 57 | MP0005410_abnormal_fertilization | 0.96670045 |
| 58 | MP0003077_abnormal_cell_cycle | 0.95697626 |
| 59 | MP0003868_abnormal_feces_composition | 0.94731650 |
| 60 | MP0002752_abnormal_somatic_nervous | 0.93198327 |
| 61 | MP0003693_abnormal_embryo_hatching | 0.92704779 |
| 62 | MP0003879_abnormal_hair_cell | 0.91044301 |
| 63 | MP0009745_abnormal_behavioral_response | 0.90918002 |
| 64 | MP0003880_abnormal_central_pattern | 0.89305135 |
| 65 | MP0002653_abnormal_ependyma_morphology | 0.88921270 |
| 66 | MP0005391_vision/eye_phenotype | 0.88907270 |
| 67 | MP0000955_abnormal_spinal_cord | 0.87942413 |
| 68 | MP0001879_abnormal_lymphatic_vessel | 0.87677765 |
| 69 | MP0001293_anophthalmia | 0.87350083 |
| 70 | MP0004859_abnormal_synaptic_plasticity | 0.86370451 |
| 71 | MP0002733_abnormal_thermal_nociception | 0.83705154 |
| 72 | MP0000569_abnormal_digit_pigmentation | 0.83533471 |
| 73 | MP0006082_CNS_inflammation | 0.82945277 |
| 74 | MP0003119_abnormal_digestive_system | 0.82643648 |
| 75 | MP0003635_abnormal_synaptic_transmissio | 0.81734250 |
| 76 | MP0003937_abnormal_limbs/digits/tail_de | 0.80457762 |
| 77 | MP0001502_abnormal_circadian_rhythm | 0.79500501 |
| 78 | MP0001485_abnormal_pinna_reflex | 0.78423191 |
| 79 | MP0000537_abnormal_urethra_morphology | 0.78297689 |
| 80 | MP0001970_abnormal_pain_threshold | 0.78241942 |
| 81 | MP0002751_abnormal_autonomic_nervous | 0.76786521 |
| 82 | MP0003938_abnormal_ear_development | 0.76729612 |
| 83 | MP0001905_abnormal_dopamine_level | 0.76140400 |
| 84 | MP0002127_abnormal_cardiovascular_syste | 0.74424045 |
| 85 | MP0003186_abnormal_redox_activity | 0.71829356 |
| 86 | MP0002229_neurodegeneration | 0.71686150 |
| 87 | MP0002572_abnormal_emotion/affect_behav | 0.71084910 |
| 88 | MP0000358_abnormal_cell_content/ | 0.70118751 |
| 89 | MP0002177_abnormal_outer_ear | 0.69518891 |
| 90 | MP0002697_abnormal_eye_size | 0.68025026 |
| 91 | MP0006072_abnormal_retinal_apoptosis | 0.67125308 |
| 92 | MP0002152_abnormal_brain_morphology | 0.66951956 |
| 93 | MP0001968_abnormal_touch/_nociception | 0.66915927 |
| 94 | MP0002882_abnormal_neuron_morphology | 0.66273058 |
| 95 | MP0006054_spinal_hemorrhage | 0.66229100 |
| 96 | MP0003137_abnormal_impulse_conducting | 0.64315713 |
| 97 | MP0003861_abnormal_nervous_system | 0.64205098 |
| 98 | MP0000013_abnormal_adipose_tissue | 0.63065181 |
| 99 | MP0002837_dystrophic_cardiac_calcinosis | 0.62673116 |
| 100 | MP0000465_gastrointestinal_hemorrhage | 0.62340364 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hypoplasia of the pons (HP:0012110) | 8.26505998 |
| 2 | Abnormality of the pons (HP:0007361) | 7.33858091 |
| 3 | Hypoplastic pelvis (HP:0008839) | 4.66174730 |
| 4 | Neonatal respiratory distress (HP:0002643) | 4.27913401 |
| 5 | Abnormality of abdominal situs (HP:0011620) | 4.25373809 |
| 6 | Abdominal situs inversus (HP:0003363) | 4.25373809 |
| 7 | Abnormality of the labia minora (HP:0012880) | 4.08587608 |
| 8 | Entropion (HP:0000621) | 3.91291647 |
| 9 | Poikiloderma (HP:0001029) | 3.87782123 |
| 10 | Supernumerary spleens (HP:0009799) | 3.35746270 |
| 11 | High anterior hairline (HP:0009890) | 3.35221821 |
| 12 | Molar tooth sign on MRI (HP:0002419) | 3.27672866 |
| 13 | Abnormality of midbrain morphology (HP:0002418) | 3.27672866 |
| 14 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.17921710 |
| 15 | Abnormality of alanine metabolism (HP:0010916) | 3.17921710 |
| 16 | Hyperalaninemia (HP:0003348) | 3.17921710 |
| 17 | Abnormality of DNA repair (HP:0003254) | 2.90287896 |
| 18 | Thin ribs (HP:0000883) | 2.89220663 |
| 19 | Amniotic constriction ring (HP:0009775) | 2.86664014 |
| 20 | Abnormality of placental membranes (HP:0011409) | 2.86664014 |
| 21 | Oligomenorrhea (HP:0000876) | 2.78605048 |
| 22 | Adactyly (HP:0009776) | 2.77336405 |
| 23 | Retinal dysplasia (HP:0007973) | 2.68736399 |
| 24 | Increased intramyocellular lipid droplets (HP:0012240) | 2.63648579 |
| 25 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.54446757 |
| 26 | Abnormality of lateral ventricle (HP:0030047) | 2.49267425 |
| 27 | Focal motor seizures (HP:0011153) | 2.49234250 |
| 28 | Asplenia (HP:0001746) | 2.48625601 |
| 29 | Decreased lacrimation (HP:0000633) | 2.47835211 |
| 30 | Increased hepatocellular lipid droplets (HP:0006565) | 2.45688221 |
| 31 | Bifid tongue (HP:0010297) | 2.43968564 |
| 32 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.42936233 |
| 33 | Poor suck (HP:0002033) | 2.37859577 |
| 34 | Sensory axonal neuropathy (HP:0003390) | 2.36260342 |
| 35 | Cerebellar dysplasia (HP:0007033) | 2.35594250 |
| 36 | Generalized aminoaciduria (HP:0002909) | 2.35519541 |
| 37 | Lipid accumulation in hepatocytes (HP:0006561) | 2.34230640 |
| 38 | Aplasia of the musculature (HP:0100854) | 2.33497556 |
| 39 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.30844943 |
| 40 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.28442011 |
| 41 | Hepatoblastoma (HP:0002884) | 2.28429283 |
| 42 | Oligodactyly (hands) (HP:0001180) | 2.21165039 |
| 43 | Popliteal pterygium (HP:0009756) | 2.18160989 |
| 44 | Polyphagia (HP:0002591) | 2.17817180 |
| 45 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.16673939 |
| 46 | Increased muscle lipid content (HP:0009058) | 2.16220474 |
| 47 | Hypoplasia of the uterus (HP:0000013) | 2.12603989 |
| 48 | Short tibia (HP:0005736) | 2.10629885 |
| 49 | Generalized hypotonia (HP:0001290) | 2.09568497 |
| 50 | Fibular aplasia (HP:0002990) | 2.03531385 |
| 51 | Abnormality of chromosome stability (HP:0003220) | 2.02915405 |
| 52 | Abnormal auditory evoked potentials (HP:0006958) | 2.01523971 |
| 53 | Rib fusion (HP:0000902) | 1.98697243 |
| 54 | Septo-optic dysplasia (HP:0100842) | 1.92461724 |
| 55 | Abnormality of the labia (HP:0000058) | 1.91859134 |
| 56 | Dry hair (HP:0011359) | 1.91386353 |
| 57 | Overriding aorta (HP:0002623) | 1.90762745 |
| 58 | Aplasia involving forearm bones (HP:0009822) | 1.89673563 |
| 59 | Absent forearm bone (HP:0003953) | 1.89673563 |
| 60 | Congenital stationary night blindness (HP:0007642) | 1.89629216 |
| 61 | Absent septum pellucidum (HP:0001331) | 1.88902953 |
| 62 | Constricted visual fields (HP:0001133) | 1.88902794 |
| 63 | Myelomeningocele (HP:0002475) | 1.88735985 |
| 64 | Keratitis (HP:0000491) | 1.88360690 |
| 65 | Pendular nystagmus (HP:0012043) | 1.88151590 |
| 66 | Chromsome breakage (HP:0040012) | 1.88085706 |
| 67 | Renal cortical cysts (HP:0000803) | 1.86877087 |
| 68 | Specific learning disability (HP:0001328) | 1.86400333 |
| 69 | Myokymia (HP:0002411) | 1.86118273 |
| 70 | Narrow nasal bridge (HP:0000446) | 1.86080550 |
| 71 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.85183085 |
| 72 | Labial hypoplasia (HP:0000066) | 1.83167554 |
| 73 | Pachygyria (HP:0001302) | 1.81524570 |
| 74 | Short humerus (HP:0005792) | 1.81167008 |
| 75 | Renal Fanconi syndrome (HP:0001994) | 1.80159682 |
| 76 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.79992798 |
| 77 | Poor head control (HP:0002421) | 1.76474530 |
| 78 | Hypoplastic female external genitalia (HP:0012815) | 1.75878758 |
| 79 | Scrotal hypoplasia (HP:0000046) | 1.75732466 |
| 80 | Hepatic necrosis (HP:0002605) | 1.74669462 |
| 81 | Abnormality of magnesium homeostasis (HP:0004921) | 1.73697075 |
| 82 | Hypoplastic iliac wings (HP:0002866) | 1.72544235 |
| 83 | Metaphyseal dysplasia (HP:0100255) | 1.71750494 |
| 84 | Congenital sensorineural hearing impairment (HP:0008527) | 1.71488918 |
| 85 | Visual hallucinations (HP:0002367) | 1.71440229 |
| 86 | Type II lissencephaly (HP:0007260) | 1.70497950 |
| 87 | Meningocele (HP:0002435) | 1.70407330 |
| 88 | Intestinal atresia (HP:0011100) | 1.68026504 |
| 89 | Hepatocellular necrosis (HP:0001404) | 1.67370918 |
| 90 | Dialeptic seizures (HP:0011146) | 1.67232212 |
| 91 | Brushfield spots (HP:0001088) | 1.67020526 |
| 92 | Generalized tonic-clonic seizures (HP:0002069) | 1.66668691 |
| 93 | Patellar aplasia (HP:0006443) | 1.66610267 |
| 94 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.65220595 |
| 95 | Abolished electroretinogram (ERG) (HP:0000550) | 1.64599055 |
| 96 | Abnormality of the septum pellucidum (HP:0007375) | 1.64280244 |
| 97 | Optic nerve hypoplasia (HP:0000609) | 1.62863229 |
| 98 | Neoplasm of the adrenal cortex (HP:0100641) | 1.61626574 |
| 99 | Epileptic encephalopathy (HP:0200134) | 1.60430378 |
| 100 | Lissencephaly (HP:0001339) | 1.56934145 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHB1 | 3.21462944 |
| 2 | GRK7 | 2.94564230 |
| 3 | BUB1 | 2.93625440 |
| 4 | BCR | 2.34124670 |
| 5 | WNK4 | 2.04232214 |
| 6 | KIT | 2.02891855 |
| 7 | STK16 | 11.0967698 |
| 8 | MST4 | 1.85156236 |
| 9 | CCNB1 | 1.78088097 |
| 10 | WNK3 | 1.64900019 |
| 11 | NUAK1 | 1.52973004 |
| 12 | DYRK3 | 1.49727357 |
| 13 | PAK6 | 1.36892701 |
| 14 | MARK1 | 1.32574382 |
| 15 | CDC7 | 1.30640208 |
| 16 | UHMK1 | 1.29623848 |
| 17 | MAP2K7 | 1.28880739 |
| 18 | CSNK1G3 | 1.26280384 |
| 19 | MAP4K2 | 1.21298106 |
| 20 | PDK2 | 1.20041836 |
| 21 | DMPK | 1.16694707 |
| 22 | CSNK1A1L | 1.15137987 |
| 23 | PLK3 | 1.14445185 |
| 24 | FRK | 1.14383949 |
| 25 | TSSK6 | 1.11738576 |
| 26 | MAP3K4 | 1.02177826 |
| 27 | CSNK1G2 | 1.01260565 |
| 28 | PNCK | 0.99854553 |
| 29 | MAPK13 | 0.99652736 |
| 30 | WEE1 | 0.95740281 |
| 31 | CSNK1G1 | 0.95684848 |
| 32 | NEK2 | 0.95185519 |
| 33 | PLK4 | 0.92931429 |
| 34 | NEK1 | 0.90825700 |
| 35 | PBK | 0.89385884 |
| 36 | BCKDK | 0.88348473 |
| 37 | MINK1 | 0.85690148 |
| 38 | PLK2 | 0.85454081 |
| 39 | TRIM28 | 0.82839286 |
| 40 | PAK3 | 0.79619837 |
| 41 | MAP3K12 | 0.79264796 |
| 42 | DAPK2 | 0.76340203 |
| 43 | VRK1 | 0.74969657 |
| 44 | PLK1 | 0.71932348 |
| 45 | STK24 | 0.69498806 |
| 46 | ERBB2 | 0.67579530 |
| 47 | EIF2AK1 | 0.66444462 |
| 48 | GRK5 | 0.66249373 |
| 49 | RAF1 | 0.65747148 |
| 50 | PINK1 | 0.63934084 |
| 51 | SIK3 | 0.63612566 |
| 52 | MAP3K11 | 0.59832922 |
| 53 | CDK3 | 0.57962384 |
| 54 | PRKACB | 0.55790395 |
| 55 | CDK19 | 0.54750089 |
| 56 | ADRBK1 | 0.54234592 |
| 57 | NTRK1 | 0.53984086 |
| 58 | EPHB2 | 0.53119909 |
| 59 | MKNK2 | 0.52312528 |
| 60 | EPHA4 | 0.51777131 |
| 61 | CSNK1A1 | 0.51670190 |
| 62 | ATR | 0.50091513 |
| 63 | NTRK3 | 0.49532001 |
| 64 | TIE1 | 0.49486056 |
| 65 | PRKG1 | 0.48791487 |
| 66 | BRSK2 | 0.48374578 |
| 67 | MATK | 0.44837630 |
| 68 | AKT2 | 0.44776148 |
| 69 | LIMK1 | 0.44428692 |
| 70 | GRK1 | 0.43737969 |
| 71 | PRKCQ | 0.43612048 |
| 72 | CSNK1E | 0.41626227 |
| 73 | ATM | 0.41022721 |
| 74 | MKNK1 | 0.40887328 |
| 75 | SRPK1 | 0.39977616 |
| 76 | PAK1 | 0.38701263 |
| 77 | BRSK1 | 0.38100202 |
| 78 | ADRBK2 | 0.37214464 |
| 79 | BRD4 | 0.37037530 |
| 80 | PIM2 | 0.36756528 |
| 81 | TTK | 0.36571300 |
| 82 | STK39 | 0.35297837 |
| 83 | ACVR1B | 0.35210617 |
| 84 | ZAK | 0.34411471 |
| 85 | EGFR | 0.34344724 |
| 86 | DYRK2 | 0.34083825 |
| 87 | AURKA | 0.31949838 |
| 88 | PKN1 | 0.31557429 |
| 89 | MAPK14 | 0.30141027 |
| 90 | PRKACA | 0.28813626 |
| 91 | EPHA3 | 0.28636222 |
| 92 | AURKB | 0.27139587 |
| 93 | EIF2AK3 | 0.26965576 |
| 94 | CDK14 | 0.25787520 |
| 95 | MAP2K4 | 0.25700056 |
| 96 | MOS | 0.25573706 |
| 97 | NME1 | 0.25519464 |
| 98 | MARK3 | 0.25450740 |
| 99 | CDK18 | 0.24837063 |
| 100 | SIK2 | 0.23081413 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 5.15844282 |
| 2 | Basal transcription factors_Homo sapiens_hsa03022 | 3.45484254 |
| 3 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.82369054 |
| 4 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.73118657 |
| 5 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.61126377 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.47802468 |
| 7 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.45285769 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.43664895 |
| 9 | Phototransduction_Homo sapiens_hsa04744 | 2.37624823 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.29303082 |
| 11 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.28201002 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.04092220 |
| 13 | Folate biosynthesis_Homo sapiens_hsa00790 | 2.02605738 |
| 14 | Olfactory transduction_Homo sapiens_hsa04740 | 1.91580863 |
| 15 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.83467701 |
| 16 | Parkinsons disease_Homo sapiens_hsa05012 | 1.77565041 |
| 17 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.75543823 |
| 18 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.68366740 |
| 19 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.62878757 |
| 20 | Sulfur relay system_Homo sapiens_hsa04122 | 1.62654419 |
| 21 | Nicotine addiction_Homo sapiens_hsa05033 | 1.62641847 |
| 22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.52805518 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.52058914 |
| 24 | Melanogenesis_Homo sapiens_hsa04916 | 1.49909715 |
| 25 | Proteasome_Homo sapiens_hsa03050 | 1.44807919 |
| 26 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.33173307 |
| 27 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.32922908 |
| 28 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.19450000 |
| 29 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.18634007 |
| 30 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.18602077 |
| 31 | Tight junction_Homo sapiens_hsa04530 | 1.16940277 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.12935619 |
| 33 | Huntingtons disease_Homo sapiens_hsa05016 | 1.12029941 |
| 34 | Mismatch repair_Homo sapiens_hsa03430 | 1.09179003 |
| 35 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.06612484 |
| 36 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.05835039 |
| 37 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.05760175 |
| 38 | Morphine addiction_Homo sapiens_hsa05032 | 1.05634822 |
| 39 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.03281956 |
| 40 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.98319709 |
| 41 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.93582113 |
| 42 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.91953807 |
| 43 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.91724829 |
| 44 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.90662851 |
| 45 | Alzheimers disease_Homo sapiens_hsa05010 | 0.87442306 |
| 46 | GABAergic synapse_Homo sapiens_hsa04727 | 0.86229914 |
| 47 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.85307849 |
| 48 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.85048196 |
| 49 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.84160116 |
| 50 | DNA replication_Homo sapiens_hsa03030 | 0.82734475 |
| 51 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.80162601 |
| 52 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.79704500 |
| 53 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.78247824 |
| 54 | Spliceosome_Homo sapiens_hsa03040 | 0.76774231 |
| 55 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.76727028 |
| 56 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.72307351 |
| 57 | RNA degradation_Homo sapiens_hsa03018 | 0.70861532 |
| 58 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.69413343 |
| 59 | Taste transduction_Homo sapiens_hsa04742 | 0.69281764 |
| 60 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.68190116 |
| 61 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.67594697 |
| 62 | Purine metabolism_Homo sapiens_hsa00230 | 0.67562053 |
| 63 | Circadian entrainment_Homo sapiens_hsa04713 | 0.65610659 |
| 64 | Axon guidance_Homo sapiens_hsa04360 | 0.65396886 |
| 65 | RNA transport_Homo sapiens_hsa03013 | 0.64650619 |
| 66 | Cell cycle_Homo sapiens_hsa04110 | 0.63989727 |
| 67 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.63407830 |
| 68 | Renin secretion_Homo sapiens_hsa04924 | 0.60806618 |
| 69 | ABC transporters_Homo sapiens_hsa02010 | 0.59881989 |
| 70 | RNA polymerase_Homo sapiens_hsa03020 | 0.59362364 |
| 71 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.58098730 |
| 72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.56805203 |
| 73 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.56212826 |
| 74 | Peroxisome_Homo sapiens_hsa04146 | 0.55740617 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.52723276 |
| 76 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.52531510 |
| 77 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.51577954 |
| 78 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.51558291 |
| 79 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.50498060 |
| 80 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.50357013 |
| 81 | Retinol metabolism_Homo sapiens_hsa00830 | 0.47515295 |
| 82 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.47146234 |
| 83 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.46180097 |
| 84 | Metabolic pathways_Homo sapiens_hsa01100 | 0.46043078 |
| 85 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.45537090 |
| 86 | Adherens junction_Homo sapiens_hsa04520 | 0.45355631 |
| 87 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.44085536 |
| 88 | Long-term depression_Homo sapiens_hsa04730 | 0.43037438 |
| 89 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.42949664 |
| 90 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.41653808 |
| 91 | Salivary secretion_Homo sapiens_hsa04970 | 0.41583143 |
| 92 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.41325401 |
| 93 | Ribosome_Homo sapiens_hsa03010 | 0.36574003 |
| 94 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.35629445 |
| 95 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.32448845 |
| 96 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.30860814 |
| 97 | Insulin secretion_Homo sapiens_hsa04911 | 0.30349564 |
| 98 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.30132982 |
| 99 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.29843247 |
| 100 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.27885712 |

