ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	9.20922798
2	neurotransmitter-gated ion channel clustering (GO:0072578)	7.25717433
3	DNA replication checkpoint (GO:0000076)	4.58394237
4	replication fork processing (GO:0031297)	4.32888582
5	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.25806274
6	keratinocyte development (GO:0003334)	4.25652618
7	nonmotile primary cilium assembly (GO:0035058)	4.25170012
8	adaptation of signaling pathway (GO:0023058)	4.14096718
9	regulation of meiosis I (GO:0060631)	4.05592280
10	DNA catabolic process, exonucleolytic (GO:0000738)	4.03943511
11	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.93023575
12	regulation of translation, ncRNA-mediated (GO:0045974)	3.93023575
13	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.93023575
14	mitochondrial genome maintenance (GO:0000002)	3.77157178
15	presynaptic membrane assembly (GO:0097105)	3.77018592
16	neural tube formation (GO:0001841)	3.70221711
17	cullin deneddylation (GO:0010388)	3.48944460
18	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.44489042
19	cerebral cortex radially oriented cell migration (GO:0021799)	3.40821446
20	sialylation (GO:0097503)	3.32316171
21	limb bud formation (GO:0060174)	3.25068701
22	retinal cone cell development (GO:0046549)	3.23710834
23	platelet dense granule organization (GO:0060155)	3.21838483
24	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.20740687
25	translesion synthesis (GO:0019985)	3.20713428
26	dentate gyrus development (GO:0021542)	3.19370641
27	somite development (GO:0061053)	3.19034501
28	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.14069544
29	postreplication repair (GO:0006301)	3.13700111
30	presynaptic membrane organization (GO:0097090)	3.13200701
31	hindbrain development (GO:0030902)	3.07648032
32	spermatid nucleus differentiation (GO:0007289)	3.05501773
33	regulation of collateral sprouting (GO:0048670)	3.03236756
34	recombinational repair (GO:0000725)	3.01182329
35	double-strand break repair via homologous recombination (GO:0000724)	2.99466045
36	intraciliary transport (GO:0042073)	2.99388610
37	water-soluble vitamin biosynthetic process (GO:0042364)	2.97406504
38	positive regulation of protein homodimerization activity (GO:0090073)	2.97173070
39	negative regulation of JUN kinase activity (GO:0043508)	2.96955633
40	regulation of mitotic spindle checkpoint (GO:1903504)	2.96184089
41	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.96184089
42	dopamine transport (GO:0015872)	2.92895006
43	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.91705604
44	epithelial cilium movement (GO:0003351)	2.90460791
45	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.90441103
46	negative regulation of dendrite development (GO:2000171)	2.90321732
47	protein deneddylation (GO:0000338)	2.87579335
48	inositol phosphate catabolic process (GO:0071545)	2.84482887
49	mitochondrial DNA replication (GO:0006264)	2.83440568
50	CENP-A containing nucleosome assembly (GO:0034080)	2.79310584
51	heme transport (GO:0015886)	2.76269632
52	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.75247986
53	cornea development in camera-type eye (GO:0061303)	2.73201255
54	chromatin remodeling at centromere (GO:0031055)	2.71843598
55	myoblast migration (GO:0051451)	2.70689749
56	lung secretory cell differentiation (GO:0061140)	2.69809688
57	ether lipid metabolic process (GO:0046485)	2.68646655
58	regulation of keratinocyte proliferation (GO:0010837)	2.68529065
59	meiotic chromosome segregation (GO:0045132)	2.66920917
60	cilium organization (GO:0044782)	2.66825390
61	fatty acid elongation (GO:0030497)	2.66807675
62	cilium movement (GO:0003341)	2.65908983
63	positive regulation of meiosis (GO:0045836)	2.65479635
64	positive regulation of male gonad development (GO:2000020)	2.63232356
65	negative regulation of execution phase of apoptosis (GO:1900118)	2.62457504
66	regulation of hexokinase activity (GO:1903299)	2.62323348
67	regulation of glucokinase activity (GO:0033131)	2.62323348
68	cilium assembly (GO:0042384)	2.61312963
69	retina layer formation (GO:0010842)	2.59561628
70	L-fucose catabolic process (GO:0042355)	2.59146316
71	fucose catabolic process (GO:0019317)	2.59146316
72	L-fucose metabolic process (GO:0042354)	2.59146316
73	regulation of sarcomere organization (GO:0060297)	2.59100186
74	regulation of male gonad development (GO:2000018)	2.58845863
75	serine family amino acid catabolic process (GO:0009071)	2.58207668
76	C-terminal protein lipidation (GO:0006501)	2.56584872
77	specification of organ identity (GO:0010092)	2.54984974
78	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.54765358
79	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.54765358
80	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.54430529
81	regulation of cofactor metabolic process (GO:0051193)	2.52970007
82	regulation of coenzyme metabolic process (GO:0051196)	2.52970007
83	glycosphingolipid biosynthetic process (GO:0006688)	2.52675334
84	regulation of timing of cell differentiation (GO:0048505)	2.52334175
85	pyrimidine nucleobase catabolic process (GO:0006208)	2.50957404
86	cerebral cortex cell migration (GO:0021795)	2.49225040
87	central nervous system neuron axonogenesis (GO:0021955)	2.48778954
88	negative regulation of telomere maintenance (GO:0032205)	2.47566931
89	kynurenine metabolic process (GO:0070189)	2.46814119
90	cilium morphogenesis (GO:0060271)	2.46358861
91	positive regulation of meiotic cell cycle (GO:0051446)	2.43857687
92	negative regulation of protein oligomerization (GO:0032460)	2.43668980
93	negative regulation of DNA binding (GO:0043392)	2.43326890
94	negative regulation of astrocyte differentiation (GO:0048712)	2.43105951
95	piRNA metabolic process (GO:0034587)	2.42723131
96	histone exchange (GO:0043486)	2.42499440
97	appendage development (GO:0048736)	2.40572467
98	limb development (GO:0060173)	2.40572467
99	renal tubule morphogenesis (GO:0061333)	2.39500472
100	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.39366952

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.14277989
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.73908992
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.46323398
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.27375237
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.01534316
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.73310316
7	VDR_22108803_ChIP-Seq_LS180_Human	2.67584054
8	E2F7_22180533_ChIP-Seq_HELA_Human	2.63091540
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59119822
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.51246622
11	FUS_26573619_Chip-Seq_HEK293_Human	2.41790411
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.36716183
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.30629846
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.23291713
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.23176205
16	EWS_26573619_Chip-Seq_HEK293_Human	2.19989495
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.16427396
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.14861501
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.06188915
20	P300_19829295_ChIP-Seq_ESCs_Human	2.03046204
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.93724968
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.92867752
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90398505
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81930837
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81619755
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.74700364
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73687951
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.73417500
29	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.70111693
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.69132314
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.69111701
32	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.65321525
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64518481
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63989706
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.63745006
36	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.63084434
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55000317
38	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.53435586
39	AR_25329375_ChIP-Seq_VCAP_Human	1.50685728
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.47927477
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47927477
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47712966
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41974939
44	STAT3_23295773_ChIP-Seq_U87_Human	1.39864830
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.35897914
46	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.35680368
47	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.35635789
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34250386
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.34250056
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33254096
51	TCF4_23295773_ChIP-Seq_U87_Human	1.33182629
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33000445
53	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.32516177
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32449255
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32264154
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.31265654
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.30959064
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29220934
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28262790
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.27438070
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27153649
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24213141
63	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.23513521
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21290077
65	AR_21572438_ChIP-Seq_LNCaP_Human	1.19777522
66	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19753617
67	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19398409
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.17645740
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17064597
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16304524
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15271249
72	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14788030
73	VDR_23849224_ChIP-Seq_CD4+_Human	1.11836081
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10770531
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10527546
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10319495
77	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08826935
78	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.08407265
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.08145872
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07744339
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.06581844
82	TP53_22573176_ChIP-Seq_HFKS_Human	1.06247744
83	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06124201
84	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.06071059
85	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.06013268
86	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.05961816
87	TBL1_22424771_ChIP-Seq_293T_Human	1.05290997
88	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05110318
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05040810
90	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.04350598
91	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04350598
92	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03871675
93	P300_18555785_Chip-Seq_ESCs_Mouse	1.03857672
94	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03520121
95	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03520121
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03322384
97	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03031722
98	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01826003
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00490895
100	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98895552

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.41638770
2	MP0008057_abnormal_DNA_replication	3.15359531
3	MP0006292_abnormal_olfactory_placode	2.75547213
4	MP0001968_abnormal_touch/_nociception	2.56397334
5	MP0003122_maternal_imprinting	2.51179969
6	MP0005367_renal/urinary_system_phenotyp	2.47974692
7	MP0000516_abnormal_urinary_system	2.47974692
8	MP0002736_abnormal_nociception_after	2.45129731
9	MP0008877_abnormal_DNA_methylation	2.42444227
10	MP0003121_genomic_imprinting	2.36281873
11	MP0005551_abnormal_eye_electrophysiolog	2.26580605
12	MP0000569_abnormal_digit_pigmentation	2.19096817
13	MP0008789_abnormal_olfactory_epithelium	1.98998375
14	MP0003718_maternal_effect	1.97781519
15	MP0006072_abnormal_retinal_apoptosis	1.96586627
16	MP0005646_abnormal_pituitary_gland	1.93586911
17	MP0008058_abnormal_DNA_repair	1.93386456
18	MP0010094_abnormal_chromosome_stability	1.91843353
19	MP0002938_white_spotting	1.90910587
20	MP0000778_abnormal_nervous_system	1.89945169
21	MP0003195_calcinosis	1.88445532
22	MP0002234_abnormal_pharynx_morphology	1.74831733
23	MP0003880_abnormal_central_pattern	1.71940293
24	MP0009053_abnormal_anal_canal	1.70371932
25	MP0004043_abnormal_pH_regulation	1.68485065
26	MP0010234_abnormal_vibrissa_follicle	1.62512774
27	MP0003786_premature_aging	1.61941854
28	MP0009780_abnormal_chondrocyte_physiolo	1.59231972
29	MP0003011_delayed_dark_adaptation	1.59176631
30	MP0005253_abnormal_eye_physiology	1.58251697
31	MP0006276_abnormal_autonomic_nervous	1.56672090
32	MP0003119_abnormal_digestive_system	1.46910861
33	MP0000647_abnormal_sebaceous_gland	1.46775564
34	MP0008995_early_reproductive_senescence	1.45053576
35	MP0004215_abnormal_myocardial_fiber	1.44745093
36	MP0001529_abnormal_vocalization	1.40885841
37	MP0005394_taste/olfaction_phenotype	1.39645711
38	MP0005499_abnormal_olfactory_system	1.39645711
39	MP0002098_abnormal_vibrissa_morphology	1.35376516
40	MP0003938_abnormal_ear_development	1.34119550
41	MP0002653_abnormal_ependyma_morphology	1.32046498
42	MP0001764_abnormal_homeostasis	1.29849501
43	MP0002751_abnormal_autonomic_nervous	1.27884300
44	MP0000427_abnormal_hair_cycle	1.26336863
45	MP0004270_analgesia	1.25824213
46	MP0000631_abnormal_neuroendocrine_gland	1.23949284
47	MP0000015_abnormal_ear_pigmentation	1.21948522
48	MP0005187_abnormal_penis_morphology	1.20455609
49	MP0001486_abnormal_startle_reflex	1.14524111
50	MP0003937_abnormal_limbs/digits/tail_de	1.12018531
51	MP0002837_dystrophic_cardiac_calcinosis	1.09870286
52	MP0002233_abnormal_nose_morphology	1.09160842
53	MP0000566_synostosis	1.08000778
54	MP0002160_abnormal_reproductive_system	1.07126055
55	MP0009046_muscle_twitch	1.06760694
56	MP0005248_abnormal_Harderian_gland	1.05710660
57	MP0005174_abnormal_tail_pigmentation	1.05253560
58	MP0010678_abnormal_skin_adnexa	1.03722220
59	MP0002163_abnormal_gland_morphology	1.02583750
60	MP0004142_abnormal_muscle_tone	1.01906025
61	MP0000372_irregular_coat_pigmentation	0.99916805
62	MP0003806_abnormal_nucleotide_metabolis	0.99523081
63	MP0002102_abnormal_ear_morphology	0.96931974
64	MP0005395_other_phenotype	0.96698983
65	MP0005195_abnormal_posterior_eye	0.96223839
66	MP0005389_reproductive_system_phenotype	0.95949823
67	MP0003252_abnormal_bile_duct	0.95203475
68	MP0001293_anophthalmia	0.95140727
69	MP0002928_abnormal_bile_duct	0.95052050
70	MP0005391_vision/eye_phenotype	0.94758794
71	MP0009250_abnormal_appendicular_skeleto	0.94576030
72	MP0008872_abnormal_physiological_respon	0.94241679
73	MP0009697_abnormal_copulation	0.94091845
74	MP0001929_abnormal_gametogenesis	0.92946790
75	MP0002557_abnormal_social/conspecific_i	0.92151419
76	MP0005075_abnormal_melanosome_morpholog	0.89805463
77	MP0005084_abnormal_gallbladder_morpholo	0.89653287
78	MP0002272_abnormal_nervous_system	0.88682495
79	MP0000537_abnormal_urethra_morphology	0.88126335
80	MP0002210_abnormal_sex_determination	0.87577677
81	MP0003136_yellow_coat_color	0.85949959
82	MP0000462_abnormal_digestive_system	0.85884378
83	MP0000653_abnormal_sex_gland	0.85749385
84	MP0001299_abnormal_eye_distance/	0.84926831
85	MP0001119_abnormal_female_reproductive	0.84056116
86	MP0003646_muscle_fatigue	0.83537860
87	MP0009745_abnormal_behavioral_response	0.83207683
88	MP0004147_increased_porphyrin_level	0.82237991
89	MP0001919_abnormal_reproductive_system	0.81602849
90	MP0005332_abnormal_amino_acid	0.81253455
91	MP0002177_abnormal_outer_ear	0.80747833
92	MP0001324_abnormal_eye_pigmentation	0.80613102
93	MP0001145_abnormal_male_reproductive	0.79716504
94	MP0000383_abnormal_hair_follicle	0.78251673
95	MP0003698_abnormal_male_reproductive	0.77597019
96	MP0003137_abnormal_impulse_conducting	0.77322549
97	MP0003693_abnormal_embryo_hatching	0.76305532
98	MP0002572_abnormal_emotion/affect_behav	0.76015743
99	MP0001177_atelectasis	0.74960095
100	MP0000538_abnormal_urinary_bladder	0.73475983

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal hair whorl (HP:0010721)	3.61442881
2	Fair hair (HP:0002286)	3.51695122
3	Methylmalonic acidemia (HP:0002912)	3.40623220
4	Abnormality of midbrain morphology (HP:0002418)	3.40275656
5	Molar tooth sign on MRI (HP:0002419)	3.40275656
6	Ectopic kidney (HP:0000086)	3.27416768
7	Retinal atrophy (HP:0001105)	3.17275323
8	Pancreatic fibrosis (HP:0100732)	3.16476988
9	Hyperventilation (HP:0002883)	3.06972264
10	Abnormality of the labia minora (HP:0012880)	3.04028396
11	Hypoproteinemia (HP:0003075)	2.97680771
12	Pancreatic cysts (HP:0001737)	2.94280762
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.88702666
14	Broad-based gait (HP:0002136)	2.84331976
15	Ependymoma (HP:0002888)	2.77753522
16	Nephronophthisis (HP:0000090)	2.75979397
17	Hyperglycinemia (HP:0002154)	2.75275332
18	Megalencephaly (HP:0001355)	2.71591136
19	Tubulointerstitial nephritis (HP:0001970)	2.71271237
20	Birth length less than 3rd percentile (HP:0003561)	2.66965828
21	Hyperlipoproteinemia (HP:0010980)	2.66162937
22	Albinism (HP:0001022)	2.64202044
23	Septate vagina (HP:0001153)	2.61197259
24	Protruding tongue (HP:0010808)	2.59863352
25	Meckel diverticulum (HP:0002245)	2.57736075
26	True hermaphroditism (HP:0010459)	2.57710788
27	Abnormality of chromosome stability (HP:0003220)	2.54090421
28	Methylmalonic aciduria (HP:0012120)	2.53956160
29	Rectal fistula (HP:0100590)	2.52300492
30	Rectovaginal fistula (HP:0000143)	2.52300492
31	Drooling (HP:0002307)	2.43501499
32	Abnormality of the ileum (HP:0001549)	2.37368774
33	Abnormality of the renal medulla (HP:0100957)	2.36147067
34	Medial flaring of the eyebrow (HP:0010747)	2.35544559
35	Hypoplastic nipples (HP:0002557)	2.32443474
36	Abnormality of the astrocytes (HP:0100707)	2.28951298
37	Astrocytoma (HP:0009592)	2.28951298
38	Generalized hypopigmentation of hair (HP:0011358)	2.28395539
39	Widely spaced teeth (HP:0000687)	2.21771660
40	Abnormality of the preputium (HP:0100587)	2.20642020
41	Excessive salivation (HP:0003781)	2.20422280
42	Postaxial hand polydactyly (HP:0001162)	2.20264237
43	Gait imbalance (HP:0002141)	2.20109637
44	Nephrogenic diabetes insipidus (HP:0009806)	2.19460996
45	Congenital primary aphakia (HP:0007707)	2.18854619
46	Absent speech (HP:0001344)	2.17661513
47	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16346955
48	Clubbing of toes (HP:0100760)	2.16130630
49	Abnormality of vitamin B metabolism (HP:0004340)	2.15588206
50	Genital tract atresia (HP:0001827)	2.13801689
51	Abolished electroretinogram (ERG) (HP:0000550)	2.07913709
52	Abnormality of the renal cortex (HP:0011035)	2.06359984
53	Tented upper lip vermilion (HP:0010804)	2.06201969
54	Glioma (HP:0009733)	2.05119465
55	Astigmatism (HP:0000483)	2.05023466
56	Renal hypoplasia (HP:0000089)	2.02049569
57	Bony spicule pigmentary retinopathy (HP:0007737)	2.01216410
58	Bifid tongue (HP:0010297)	2.01006113
59	Increased corneal curvature (HP:0100692)	2.00343459
60	Keratoconus (HP:0000563)	2.00343459
61	Vaginal atresia (HP:0000148)	1.99814774
62	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.99241996
63	Vaginal fistula (HP:0004320)	1.95937094
64	Chronic hepatic failure (HP:0100626)	1.95220107
65	Hypoplastic pelvis (HP:0008839)	1.94373949
66	Sloping forehead (HP:0000340)	1.94087888
67	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.93572566
68	Hypoplasia of the fovea (HP:0007750)	1.93572566
69	Hemiparesis (HP:0001269)	1.91321958
70	Congenital hepatic fibrosis (HP:0002612)	1.90552077
71	High anterior hairline (HP:0009890)	1.90174456
72	Shawl scrotum (HP:0000049)	1.89801819
73	Pendular nystagmus (HP:0012043)	1.89507437
74	Anencephaly (HP:0002323)	1.89129597
75	Intestinal fistula (HP:0100819)	1.89121021
76	Small intestinal stenosis (HP:0012848)	1.87153400
77	Duodenal stenosis (HP:0100867)	1.87153400
78	Postaxial foot polydactyly (HP:0001830)	1.86348143
79	Abnormality of the duodenum (HP:0002246)	1.86099796
80	Epileptic encephalopathy (HP:0200134)	1.84073094
81	Oculomotor apraxia (HP:0000657)	1.83504365
82	Abnormality of macular pigmentation (HP:0008002)	1.81469902
83	Hamartoma of the eye (HP:0010568)	1.80632035
84	Poor eye contact (HP:0000817)	1.80205052
85	Inability to walk (HP:0002540)	1.79895857
86	Aganglionic megacolon (HP:0002251)	1.78930406
87	Abnormality of the carotid arteries (HP:0005344)	1.78737483
88	Abnormality of serine family amino acid metabolism (HP:0010894)	1.78093439
89	Abnormality of glycine metabolism (HP:0010895)	1.78093439
90	Hypomagnesemia (HP:0002917)	1.78014397
91	Clitoromegaly (HP:0000057)	1.77486922
92	Narrow forehead (HP:0000341)	1.76157221
93	Hypoplasia of the pons (HP:0012110)	1.74616873
94	Congenital stationary night blindness (HP:0007642)	1.73886115
95	Labial hypoplasia (HP:0000066)	1.73607621
96	Triphalangeal thumb (HP:0001199)	1.72841074
97	Tubular atrophy (HP:0000092)	1.71824603
98	Hypoplastic labia majora (HP:0000059)	1.71787975
99	Preaxial hand polydactyly (HP:0001177)	1.71543830
100	Tubulointerstitial abnormality (HP:0001969)	1.71006637

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	7.74906624
2	FRK	3.95319881
3	CCNB1	3.04142876
4	BCKDK	2.97066107
5	NUAK1	2.87685457
6	TRIM28	2.53064647
7	PNCK	2.29836155
8	MAPK13	2.27976503
9	MARK1	2.17117870
10	ERBB3	2.01167249
11	MAPKAPK3	2.00876135
12	BMPR1B	1.96833628
13	MKNK2	1.84734296
14	TNIK	1.75901105
15	EEF2K	1.75002169
16	MAP3K4	1.73440188
17	BUB1	1.71679948
18	FLT3	1.58713925
19	TRPM7	1.55892041
20	MKNK1	1.47145870
21	CASK	1.35996965
22	MAPKAPK5	1.22769384
23	PLK2	1.20305608
24	ACVR1B	1.15963835
25	BCR	1.13473505
26	WEE1	1.10539761
27	ADRBK2	1.09090553
28	SIK3	1.08481545
29	EIF2AK1	1.07698309
30	PLK3	1.07406982
31	BRSK2	1.07289787
32	MAP4K2	1.05212781
33	RPS6KB2	0.99734398
34	NTRK2	0.99055048
35	OXSR1	0.98843324
36	ZAK	0.98559401
37	PKN1	0.96311613
38	NTRK3	0.94504889
39	MAP2K7	0.92887467
40	PTK2B	0.87214345
41	SGK2	0.85327930
42	PLK1	0.85087400
43	AKT3	0.84581610
44	SIK2	0.81203566
45	PINK1	0.81150198
46	CDC7	0.79448224
47	FGFR2	0.77883095
48	ATR	0.77285872
49	CAMK1G	0.75871629
50	VRK1	0.74335507
51	GRK1	0.71807964
52	NLK	0.69968702
53	STK39	0.68852931
54	CSNK1G1	0.68537971
55	YES1	0.67645015
56	PRKAA2	0.66213643
57	PHKG2	0.62982469
58	PHKG1	0.62982469
59	GRK5	0.62657688
60	ILK	0.62410270
61	NEK2	0.57683816
62	PRKCE	0.56246088
63	PAK3	0.54920927
64	EPHA3	0.54259586
65	DYRK1A	0.53872780
66	SGK223	0.52954329
67	SGK494	0.52954329
68	CAMK1	0.51567687
69	ADRBK1	0.51294360
70	EPHA4	0.49713199
71	MAP3K2	0.48747647
72	TGFBR1	0.47470458
73	INSRR	0.46805490
74	PRKD3	0.43292293
75	PRKCZ	0.42253351
76	DYRK2	0.42215754
77	VRK2	0.39902435
78	ATM	0.39664774
79	CSNK1G2	0.38340001
80	PRKCG	0.36937473
81	CSNK1A1	0.36767086
82	PIM2	0.36306845
83	EIF2AK3	0.35564454
84	STK16	0.35223865
85	NME1	0.33543961
86	TSSK6	0.33071133
87	CDK3	0.31650429
88	CAMK2A	0.31540728
89	CDK19	0.30926754
90	CSNK1D	0.30776096
91	CHEK2	0.30652354
92	MARK3	0.30325787
93	TEC	0.30002758
94	FGR	0.29372863
95	IRAK2	0.29298664
96	PRKAA1	0.27259112
97	PLK4	0.26921078
98	SGK3	0.26878280
99	IRAK1	0.26304751
100	STK3	0.24739998

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	4.29594058
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.47224796
3	Folate biosynthesis_Homo sapiens_hsa00790	3.39716171
4	Protein export_Homo sapiens_hsa03060	2.68632935
5	Phototransduction_Homo sapiens_hsa04744	2.65813066
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.46351112
7	Homologous recombination_Homo sapiens_hsa03440	2.33698273
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.30744272
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.16859806
10	Propanoate metabolism_Homo sapiens_hsa00640	2.08963988
11	DNA replication_Homo sapiens_hsa03030	1.96203380
12	Steroid biosynthesis_Homo sapiens_hsa00100	1.90983368
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.77544598
14	Peroxisome_Homo sapiens_hsa04146	1.71568008
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.66745757
16	Mismatch repair_Homo sapiens_hsa03430	1.65727395
17	Butanoate metabolism_Homo sapiens_hsa00650	1.63981388
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.57251497
19	Fatty acid elongation_Homo sapiens_hsa00062	1.53643070
20	Sulfur relay system_Homo sapiens_hsa04122	1.45400309
21	Basal transcription factors_Homo sapiens_hsa03022	1.43067559
22	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.39965215
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.39732025
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39388392
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.37598336
26	One carbon pool by folate_Homo sapiens_hsa00670	1.36840134
27	Nicotine addiction_Homo sapiens_hsa05033	1.34739909
28	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.33935044
29	Caffeine metabolism_Homo sapiens_hsa00232	1.33596412
30	RNA degradation_Homo sapiens_hsa03018	1.26247290
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25761362
32	Proteasome_Homo sapiens_hsa03050	1.25135843
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.24707265
34	Parkinsons disease_Homo sapiens_hsa05012	1.15727319
35	RNA polymerase_Homo sapiens_hsa03020	1.07664673
36	Regulation of autophagy_Homo sapiens_hsa04140	1.07656459
37	RNA transport_Homo sapiens_hsa03013	1.04858928
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.04554181
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04197793
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.03938882
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.01256227
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97022436
43	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.96399366
44	Oocyte meiosis_Homo sapiens_hsa04114	0.96270860
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.94012948
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92744249
47	Retinol metabolism_Homo sapiens_hsa00830	0.90003639
48	Base excision repair_Homo sapiens_hsa03410	0.89468810
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88774031
50	Circadian entrainment_Homo sapiens_hsa04713	0.85966949
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.85301233
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.85266000
53	ABC transporters_Homo sapiens_hsa02010	0.84633042
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84095094
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83120615
56	Purine metabolism_Homo sapiens_hsa00230	0.80197642
57	Cell cycle_Homo sapiens_hsa04110	0.79138448
58	Morphine addiction_Homo sapiens_hsa05032	0.77076594
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.76749038
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76740288
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.76547612
62	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.76050332
63	Spliceosome_Homo sapiens_hsa03040	0.75724002
64	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.75628451
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75181143
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70546978
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.69544204
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.66176371
69	Olfactory transduction_Homo sapiens_hsa04740	0.65005982
70	Metabolic pathways_Homo sapiens_hsa01100	0.64565134
71	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.64338021
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64055042
73	Taste transduction_Homo sapiens_hsa04742	0.63053021
74	Circadian rhythm_Homo sapiens_hsa04710	0.62893078
75	Huntingtons disease_Homo sapiens_hsa05016	0.62237417
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.61750281
77	GABAergic synapse_Homo sapiens_hsa04727	0.61412301
78	Serotonergic synapse_Homo sapiens_hsa04726	0.61131960
79	p53 signaling pathway_Homo sapiens_hsa04115	0.60731452
80	Insulin secretion_Homo sapiens_hsa04911	0.59715630
81	Alzheimers disease_Homo sapiens_hsa05010	0.57668546
82	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.57460544
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.57360597
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57132008
85	Long-term depression_Homo sapiens_hsa04730	0.56536756
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.54979996
87	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54162640
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.52021509
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51808115
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.51538395
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.51134518
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49823325
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46952664
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.46766204
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.46125497
96	Glutathione metabolism_Homo sapiens_hsa00480	0.42640909
97	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.42144523
98	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41019700
99	Renin secretion_Homo sapiens_hsa04924	0.38108009
100	Salivary secretion_Homo sapiens_hsa04970	0.36398326

MTND1P32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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