ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.48877292
2	behavioral response to nicotine (GO:0035095)	5.37965551
3	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	5.34405692
4	rRNA catabolic process (GO:0016075)	4.69978338
5	piRNA metabolic process (GO:0034587)	4.45243507
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.35005202
7	regulation of mesoderm development (GO:2000380)	4.05307385
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.88971311
9	regulation of female receptivity (GO:0045924)	3.77983443
10	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.71307509
11	adaptation of signaling pathway (GO:0023058)	3.66534095
12	DNA methylation involved in gamete generation (GO:0043046)	3.61652383
13	positive regulation of defense response to virus by host (GO:0002230)	3.50204176
14	rhodopsin mediated signaling pathway (GO:0016056)	3.49512889
15	cell wall macromolecule catabolic process (GO:0016998)	3.40664359
16	preassembly of GPI anchor in ER membrane (GO:0016254)	3.32236627
17	positive regulation of fatty acid transport (GO:2000193)	3.26714771
18	negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)	3.26240730
19	endoderm formation (GO:0001706)	3.25236455
20	male meiosis (GO:0007140)	3.12338424
21	positive regulation of organelle assembly (GO:1902117)	3.10368802
22	female mating behavior (GO:0060180)	3.07252378
23	myoblast migration (GO:0051451)	3.05658389
24	interferon-gamma production (GO:0032609)	3.04855602
25	positive thymic T cell selection (GO:0045059)	3.01047953
26	replication fork processing (GO:0031297)	3.00269625
27	tryptophan catabolic process (GO:0006569)	2.96242868
28	indole-containing compound catabolic process (GO:0042436)	2.96242868
29	indolalkylamine catabolic process (GO:0046218)	2.96242868
30	kynurenine metabolic process (GO:0070189)	2.92256040
31	regulation of regulatory T cell differentiation (GO:0045589)	2.90581914
32	growth hormone receptor signaling pathway (GO:0060396)	2.88960947
33	negative thymic T cell selection (GO:0045060)	2.87264337
34	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.82859933
35	termination of RNA polymerase III transcription (GO:0006386)	2.82859933
36	rRNA modification (GO:0000154)	2.82036817
37	cell wall macromolecule metabolic process (GO:0044036)	2.80767432
38	cellular response to interferon-beta (GO:0035458)	2.78916161
39	response to interferon-beta (GO:0035456)	2.75989888
40	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.74979954
41	drug catabolic process (GO:0042737)	2.74398684
42	tryptophan metabolic process (GO:0006568)	2.74187166
43	protein K6-linked ubiquitination (GO:0085020)	2.73808455
44	inositol phosphate dephosphorylation (GO:0046855)	2.73628319
45	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.73628319
46	protein import into peroxisome matrix (GO:0016558)	2.72470518
47	positive regulation of T-helper 1 type immune response (GO:0002827)	2.68249145
48	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.67906808
49	negative T cell selection (GO:0043383)	2.67766646
50	indolalkylamine metabolic process (GO:0006586)	2.67641605
51	positive regulation of meiosis (GO:0045836)	2.66904778
52	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.66102402
53	protein polyglutamylation (GO:0018095)	2.66055411
54	S-adenosylmethionine metabolic process (GO:0046500)	2.60407406
55	positive T cell selection (GO:0043368)	2.60366031
56	somite development (GO:0061053)	2.60248985
57	protein prenylation (GO:0018342)	2.60220460
58	prenylation (GO:0097354)	2.60220460
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.59764025
60	positive regulation of DNA recombination (GO:0045911)	2.59286015
61	oxidative demethylation (GO:0070989)	2.58714166
62	cellular response to growth hormone stimulus (GO:0071378)	2.57759404
63	platelet dense granule organization (GO:0060155)	2.56969211
64	negative regulation of B cell apoptotic process (GO:0002903)	2.56594658
65	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.55652510
66	protein-cofactor linkage (GO:0018065)	2.53496715
67	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.52970424
68	polyol catabolic process (GO:0046174)	2.52007782
69	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.51977163
70	positive regulation of icosanoid secretion (GO:0032305)	2.51954628
71	negative regulation of mast cell activation (GO:0033004)	2.51785122
72	positive regulation of prostaglandin secretion (GO:0032308)	2.50910147
73	positive regulation of meiotic cell cycle (GO:0051446)	2.47774062
74	L-fucose catabolic process (GO:0042355)	2.45776533
75	fucose catabolic process (GO:0019317)	2.45776533
76	L-fucose metabolic process (GO:0042354)	2.45776533
77	ncRNA catabolic process (GO:0034661)	2.44869056
78	regulation of defense response to virus by host (GO:0050691)	2.44439811
79	DNA modification (GO:0006304)	2.44338168
80	protein targeting to vacuole (GO:0006623)	2.42864161
81	protein targeting to lysosome (GO:0006622)	2.42864161
82	establishment of protein localization to vacuole (GO:0072666)	2.42864161
83	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.40694396
84	cellular response to exogenous dsRNA (GO:0071360)	2.40668108
85	inositol phosphate catabolic process (GO:0071545)	2.39747223
86	positive regulation of glomerulus development (GO:0090193)	2.39458382
87	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	2.38115089
88	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.37864294
89	cytidine deamination (GO:0009972)	2.37384190
90	cytidine metabolic process (GO:0046087)	2.37384190
91	cytidine catabolic process (GO:0006216)	2.37384190
92	male meiosis I (GO:0007141)	2.37058230
93	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.37004431
94	regulation of B cell apoptotic process (GO:0002902)	2.33706929
95	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.33584247
96	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.33584247
97	NADH dehydrogenase complex assembly (GO:0010257)	2.33584247
98	rRNA methylation (GO:0031167)	2.32779550
99	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.31197345
100	DNA demethylation (GO:0080111)	2.31139742

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.86755536
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.02596407
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.86466413
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.69030600
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.57879790
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.56178684
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.48390229
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.38796365
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.32992981
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.31735472
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.25160199
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.24562272
13	EWS_26573619_Chip-Seq_HEK293_Human	2.21885851
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.18420571
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15469051
16	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.13832484
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06015516
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.04222541
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.97064155
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.92812368
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.91578657
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.90450817
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.86191999
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.86189292
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.82894960
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.81739522
27	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.79259277
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.78216091
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68654307
30	RUNX_20019798_ChIP-Seq_JUKART_Human	1.68200214
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67000397
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66423750
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.65880446
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65339439
35	GATA3_26560356_Chip-Seq_TH2_Human	1.61493076
36	FUS_26573619_Chip-Seq_HEK293_Human	1.59520497
37	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.59420125
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.57826517
39	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.56810234
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47838627
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47838627
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.47357419
43	AR_20517297_ChIP-Seq_VCAP_Human	1.41985810
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39756474
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39756474
46	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.34581623
47	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.33386727
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33184377
49	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.32367713
50	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.31162754
51	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.30936152
52	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.30342924
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.28317561
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28317561
55	EZH2_22144423_ChIP-Seq_EOC_Human	1.26971804
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26144805
57	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.24987066
58	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.24963860
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.24352673
60	P300_19829295_ChIP-Seq_ESCs_Human	1.23059250
61	STAT3_23295773_ChIP-Seq_U87_Human	1.22543090
62	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.21370215
63	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20701379
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18993256
65	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18891164
66	STAT1_20625510_ChIP-Seq_HELA_Human	1.18734328
67	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.17496600
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16105205
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15972008
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15679513
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15458468
72	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15290444
73	NCOR_22424771_ChIP-Seq_293T_Human	1.13929191
74	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13339819
75	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11378310
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11036222
77	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10998348
78	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.10381558
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10291172
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09432975
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09066629
82	TCF4_23295773_ChIP-Seq_U87_Human	1.08290644
83	TAF15_26573619_Chip-Seq_HEK293_Human	1.07404992
84	CIITA_25753668_ChIP-Seq_RAJI_Human	1.07127121
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06481727
86	GATA3_26560356_Chip-Seq_TH1_Human	1.06101782
87	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.04278460
88	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03619900
89	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.03006933
90	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.02953803
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02391672
92	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.01944597
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01810281
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00890421
95	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00817004
96	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00467948
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99947931
98	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.99457210
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.99103623
100	MYB_26560356_Chip-Seq_TH2_Human	0.98986798

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	3.78553758
2	MP0002102_abnormal_ear_morphology	3.29194808
3	MP0002876_abnormal_thyroid_physiology	3.17743795
4	MP0008877_abnormal_DNA_methylation	3.11559606
5	MP0005646_abnormal_pituitary_gland	3.01452866
6	MP0003646_muscle_fatigue	2.67527811
7	MP0002163_abnormal_gland_morphology	2.64721522
8	MP0002837_dystrophic_cardiac_calcinosis	2.49405898
9	MP0000569_abnormal_digit_pigmentation	2.45468541
10	MP0001835_abnormal_antigen_presentation	2.24166474
11	MP0008872_abnormal_physiological_respon	2.22018992
12	MP0001986_abnormal_taste_sensitivity	2.07762445
13	MP0005645_abnormal_hypothalamus_physiol	1.96970585
14	MP0001968_abnormal_touch/_nociception	1.95373067
15	MP0005551_abnormal_eye_electrophysiolog	1.83162061
16	MP0008875_abnormal_xenobiotic_pharmacok	1.79876913
17	MP0004145_abnormal_muscle_electrophysio	1.73798616
18	MP0005167_abnormal_blood-brain_barrier	1.70510313
19	MP0000685_abnormal_immune_system	1.68025171
20	MP0005379_endocrine/exocrine_gland_phen	1.64956140
21	MP0004885_abnormal_endolymph	1.64464611
22	MP0005671_abnormal_response_to	1.60647578
23	MP0004142_abnormal_muscle_tone	1.56701716
24	MP0008775_abnormal_heart_ventricle	1.54369645
25	MP0001800_abnormal_humoral_immune	1.52249339
26	MP0003786_premature_aging	1.51410398
27	MP0006072_abnormal_retinal_apoptosis	1.49930445
28	MP0002148_abnormal_hypersensitivity_rea	1.48924550
29	MP0002166_altered_tumor_susceptibility	1.48288824
30	MP0000383_abnormal_hair_follicle	1.47683831
31	MP0009780_abnormal_chondrocyte_physiolo	1.45896213
32	MP0003950_abnormal_plasma_membrane	1.45252595
33	MP0010386_abnormal_urinary_bladder	1.44998787
34	MP0002160_abnormal_reproductive_system	1.43381790
35	MP0006292_abnormal_olfactory_placode	1.42147770
36	MP0003724_increased_susceptibility_to	1.41434456
37	MP0003763_abnormal_thymus_physiology	1.40221593
38	MP0005389_reproductive_system_phenotype	1.36916328
39	MP0001853_heart_inflammation	1.35780173
40	MP0005387_immune_system_phenotype	1.33330928
41	MP0001790_abnormal_immune_system	1.33330928
42	MP0003195_calcinosis	1.33112767
43	MP0005410_abnormal_fertilization	1.30706151
44	MP0005000_abnormal_immune_tolerance	1.30061742
45	MP0000013_abnormal_adipose_tissue	1.26528829
46	MP0002272_abnormal_nervous_system	1.24243072
47	MP0003283_abnormal_digestive_organ	1.23691919
48	MP0002006_tumorigenesis	1.15876689
49	MP0002277_abnormal_respiratory_mucosa	1.15209481
50	MP0004147_increased_porphyrin_level	1.09014092
51	MP0000613_abnormal_salivary_gland	1.07231191
52	MP0000372_irregular_coat_pigmentation	1.07225737
53	MP0002735_abnormal_chemical_nociception	1.05858997
54	MP0002723_abnormal_immune_serum	1.05442072
55	MP0001919_abnormal_reproductive_system	1.04893259
56	MP0009764_decreased_sensitivity_to	1.04691624
57	MP0001485_abnormal_pinna_reflex	1.02953812
58	MP0009046_muscle_twitch	1.02517825
59	MP0002452_abnormal_antigen_presenting	1.01533657
60	MP0005075_abnormal_melanosome_morpholog	1.00507924
61	MP0004084_abnormal_cardiac_muscle	1.00405829
62	MP0004130_abnormal_muscle_cell	0.98980788
63	MP0001440_abnormal_grooming_behavior	0.97972660
64	MP0001529_abnormal_vocalization	0.97757378
65	MP0005220_abnormal_exocrine_pancreas	0.97752654
66	MP0000230_abnormal_systemic_arterial	0.97358869
67	MP0003567_abnormal_fetal_cardiomyocyte	0.94890702
68	MP0002420_abnormal_adaptive_immunity	0.93510414
69	MP0001819_abnormal_immune_cell	0.90765001
70	MP0008058_abnormal_DNA_repair	0.89375881
71	MP0009745_abnormal_behavioral_response	0.88630543
72	MP0003806_abnormal_nucleotide_metabolis	0.88037940
73	MP0003787_abnormal_imprinting	0.86971562
74	MP0000427_abnormal_hair_cycle	0.85912254
75	MP0003866_abnormal_defecation	0.85447278
76	MP0009785_altered_susceptibility_to	0.85191393
77	MP0004215_abnormal_myocardial_fiber	0.84498475
78	MP0003011_delayed_dark_adaptation	0.83799740
79	MP0002736_abnormal_nociception_after	0.83409556
80	MP0001501_abnormal_sleep_pattern	0.82952604
81	MP0008007_abnormal_cellular_replicative	0.82266703
82	MP0005647_abnormal_sex_gland	0.81473841
83	MP0004019_abnormal_vitamin_homeostasis	0.81292756
84	MP0001984_abnormal_olfaction	0.80091256
85	MP0005253_abnormal_eye_physiology	0.79674540
86	MP0002733_abnormal_thermal_nociception	0.78295765
87	MP0002693_abnormal_pancreas_physiology	0.77725741
88	MP0001764_abnormal_homeostasis	0.77095475
89	MP0002009_preneoplasia	0.76543694
90	MP0001486_abnormal_startle_reflex	0.76132775
91	MP0003879_abnormal_hair_cell	0.74234093
92	MP0000689_abnormal_spleen_morphology	0.73615685
93	MP0009333_abnormal_splenocyte_physiolog	0.72701018
94	MP0010155_abnormal_intestine_physiology	0.72426612
95	MP0003137_abnormal_impulse_conducting	0.72164112
96	MP0001765_abnormal_ion_homeostasis	0.71894443
97	MP0002398_abnormal_bone_marrow	0.70776934
98	MP0000716_abnormal_immune_system	0.70164921
99	MP0002933_joint_inflammation	0.69771207
100	MP0000631_abnormal_neuroendocrine_gland	0.69525908

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.16809376
2	Keratoconus (HP:0000563)	3.74608031
3	Increased corneal curvature (HP:0100692)	3.74608031
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.70585827
5	Congenital, generalized hypertrichosis (HP:0004540)	3.44574537
6	Pancreatic cysts (HP:0001737)	3.41979040
7	Abolished electroretinogram (ERG) (HP:0000550)	3.31467813
8	Congenital stationary night blindness (HP:0007642)	3.28880323
9	Decreased central vision (HP:0007663)	3.28330463
10	IgG deficiency (HP:0004315)	3.26044563
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.07854528
12	Type II lissencephaly (HP:0007260)	3.04862243
13	Abnormality of the renal cortex (HP:0011035)	2.99198957
14	Abnormality of the nasal septum (HP:0000419)	2.87204246
15	Stomatitis (HP:0010280)	2.83772097
16	Pancreatic fibrosis (HP:0100732)	2.79370310
17	Lipid accumulation in hepatocytes (HP:0006561)	2.75727361
18	Abnormality of midbrain morphology (HP:0002418)	2.68243352
19	Molar tooth sign on MRI (HP:0002419)	2.68243352
20	Pendular nystagmus (HP:0012043)	2.65025429
21	Large for gestational age (HP:0001520)	2.64175730
22	Fair hair (HP:0002286)	2.63868061
23	Clumsiness (HP:0002312)	2.62728148
24	Polydipsia (HP:0001959)	2.62235167
25	Abnormal drinking behavior (HP:0030082)	2.62235167
26	Renal cortical cysts (HP:0000803)	2.61602744
27	Cerebellar dysplasia (HP:0007033)	2.57054622
28	Attenuation of retinal blood vessels (HP:0007843)	2.56121419
29	Increased IgM level (HP:0003496)	2.54576039
30	Decreased circulating renin level (HP:0003351)	2.49880151
31	Duplicated collecting system (HP:0000081)	2.47187172
32	True hermaphroditism (HP:0010459)	2.46971095
33	Abnormality of the renal collecting system (HP:0004742)	2.43751094
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.41414413
35	Abnormality of alanine metabolism (HP:0010916)	2.41414413
36	Hyperalaninemia (HP:0003348)	2.41414413
37	Nephronophthisis (HP:0000090)	2.40825087
38	Methylmalonic acidemia (HP:0002912)	2.38599611
39	Carpal bone hypoplasia (HP:0001498)	2.35251350
40	Abnormality of the pons (HP:0007361)	2.34764281
41	Asplenia (HP:0001746)	2.33702693
42	Bilateral microphthalmos (HP:0007633)	2.31609337
43	Abnormality of the prostate (HP:0008775)	2.28697395
44	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.27891861
45	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.27798986
46	Agitation (HP:0000713)	2.26911805
47	Methylmalonic aciduria (HP:0012120)	2.25497516
48	Constricted visual fields (HP:0001133)	2.22442962
49	Increased hepatocellular lipid droplets (HP:0006565)	2.20181923
50	Abnormality of the costochondral junction (HP:0000919)	2.18470357
51	Focal motor seizures (HP:0011153)	2.11745227
52	Abnormality of the renal medulla (HP:0100957)	2.11336582
53	Metabolic alkalosis (HP:0200114)	2.10701138
54	Chorioretinal atrophy (HP:0000533)	2.08625613
55	Tubular atrophy (HP:0000092)	2.06932483
56	Abnormality of T cell physiology (HP:0011840)	2.03730314
57	Visual hallucinations (HP:0002367)	2.03599435
58	Broad-based gait (HP:0002136)	2.03239081
59	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.00290113
60	Absent/shortened dynein arms (HP:0200106)	2.00290113
61	Polyuria (HP:0000103)	1.99685495
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.97815688
63	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.94813484
64	Acute necrotizing encephalopathy (HP:0006965)	1.91416378
65	Recurrent cutaneous fungal infections (HP:0011370)	1.90170833
66	Chronic mucocutaneous candidiasis (HP:0002728)	1.90170833
67	Optic disc pallor (HP:0000543)	1.90021620
68	Hypoplasia of the uterus (HP:0000013)	1.89269429
69	Mitochondrial inheritance (HP:0001427)	1.87942549
70	Genetic anticipation (HP:0003743)	1.87594498
71	Hypomagnesemia (HP:0002917)	1.87147604
72	Cystic liver disease (HP:0006706)	1.85750058
73	Increased CSF lactate (HP:0002490)	1.85642866
74	Generalized hypopigmentation of hair (HP:0011358)	1.85600038
75	Progressive inability to walk (HP:0002505)	1.85325306
76	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.84255596
77	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.84208324
78	Enlarged kidneys (HP:0000105)	1.83928885
79	Alkalosis (HP:0001948)	1.83337870
80	Type 2 muscle fiber atrophy (HP:0003554)	1.82056517
81	Stomach cancer (HP:0012126)	1.81139305
82	Inability to walk (HP:0002540)	1.81126943
83	Panhypogammaglobulinemia (HP:0003139)	1.80807363
84	Concave nail (HP:0001598)	1.79944600
85	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78778636
86	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.78727715
87	Gaze-evoked nystagmus (HP:0000640)	1.78032627
88	Autoimmune thrombocytopenia (HP:0001973)	1.77917045
89	Renal Fanconi syndrome (HP:0001994)	1.77755540
90	Short hallux (HP:0010109)	1.77514929
91	Hypokalemic alkalosis (HP:0001949)	1.76388860
92	Thyroid-stimulating hormone excess (HP:0002925)	1.75697613
93	Absent phalangeal crease (HP:0006109)	1.75033121
94	Progressive macrocephaly (HP:0004481)	1.74691109
95	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.73639806
96	Hypoplasia of the pons (HP:0012110)	1.72953549
97	Elevated erythrocyte sedimentation rate (HP:0003565)	1.72113646
98	Abnormal urine output (HP:0012590)	1.72072600
99	Clubbing of toes (HP:0100760)	1.71532785
100	3-Methylglutaconic aciduria (HP:0003535)	1.71001321

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.56051631
2	FRK	4.34562583
3	BMPR1B	3.14667860
4	ACVR1B	2.93525930
5	TLK1	2.66898213
6	ADRBK2	2.37613766
7	ZAK	2.34569941
8	WNK4	2.33349899
9	TAOK3	2.25728064
10	GRK1	2.24413178
11	KIT	2.00864805
12	AKT3	1.92714820
13	EIF2AK3	1.81496105
14	MST4	1.81323517
15	TEC	1.80163614
16	CAMKK2	1.78948672
17	STK39	1.63933162
18	OXSR1	1.58242641
19	ITK	1.51563598
20	PINK1	1.49091422
21	NUAK1	1.47705105
22	RIPK4	1.41180222
23	VRK1	1.40454722
24	TGFBR1	1.38466176
25	EIF2AK1	1.37110906
26	GRK7	1.35031683
27	PIK3CG	1.29996092
28	ADRBK1	1.22639532
29	MAP4K1	1.17663753
30	IKBKB	1.16285772
31	FLT3	1.12746133
32	SYK	1.12158227
33	PDK2	1.11802757
34	MAPKAPK3	1.10013401
35	BCR	1.09450888
36	PHKG2	1.08976477
37	PHKG1	1.08976477
38	EIF2AK2	1.05669177
39	GRK5	1.02766995
40	BRSK2	1.02659468
41	FES	1.00109688
42	TIE1	0.99770957
43	MAPK11	0.99483592
44	MKNK2	0.95260396
45	SRPK1	0.89173817
46	ERBB3	0.83737613
47	STK16	0.83514151
48	PBK	0.76868792
49	CDK8	0.73440501
50	BMPR2	0.73102121
51	RPS6KA5	0.71218911
52	MAP3K14	0.69357793
53	IGF1R	0.67096407
54	PRKCE	0.64090257
55	NME1	0.63566765
56	MAP2K2	0.63439170
57	DAPK2	0.63026965
58	SCYL2	0.60927188
59	IKBKE	0.60370624
60	CAMKK1	0.58459772
61	VRK2	0.58279675
62	MKNK1	0.57161858
63	MAP4K2	0.56969213
64	STK10	0.56922285
65	MAP2K6	0.56586005
66	CHUK	0.56505290
67	INSRR	0.55854740
68	BCKDK	0.55644384
69	PLK3	0.55381126
70	RPS6KA4	0.55338427
71	LCK	0.55141480
72	TRIM28	0.55092842
73	PRKCI	0.51976107
74	WNK3	0.51527772
75	ABL1	0.51487696
76	MAPK13	0.51362428
77	RPS6KA6	0.51296141
78	ATR	0.50956976
79	HCK	0.50596698
80	PLK2	0.50377907
81	PRKCG	0.50343752
82	PRKCQ	0.49014165
83	LYN	0.48634857
84	TNIK	0.46649384
85	PIK3CA	0.44067678
86	PTK2B	0.42506950
87	OBSCN	0.40820762
88	CSNK1A1	0.38108498
89	CSF1R	0.37765143
90	PRKCA	0.37474496
91	MELK	0.35470904
92	CAMK2A	0.35368298
93	PAK3	0.34392481
94	BTK	0.34122978
95	JAK3	0.33896576
96	PRKACA	0.33891356
97	ATM	0.33630010
98	PRKCD	0.29112792
99	HIPK2	0.28467825
100	KDR	0.28070793

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.70987764
2	Allograft rejection_Homo sapiens_hsa05330	3.48889316
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.35169816
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.20063044
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.18288770
6	Phototransduction_Homo sapiens_hsa04744	2.96559825
7	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.85077952
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.82443728
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.67082334
10	Caffeine metabolism_Homo sapiens_hsa00232	2.20710729
11	RNA polymerase_Homo sapiens_hsa03020	2.18696862
12	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.13674544
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.10738786
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.90398533
15	Proteasome_Homo sapiens_hsa03050	1.79882663
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72206646
17	Homologous recombination_Homo sapiens_hsa03440	1.69922810
18	RNA degradation_Homo sapiens_hsa03018	1.68047579
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.60519532
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.59786311
21	Peroxisome_Homo sapiens_hsa04146	1.53965201
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.48298875
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.37010908
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.35976487
25	Sulfur metabolism_Homo sapiens_hsa00920	1.34373845
26	One carbon pool by folate_Homo sapiens_hsa00670	1.26992627
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.25878303
28	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.24045554
29	Basal transcription factors_Homo sapiens_hsa03022	1.23317322
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.21101003
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20359299
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04072485
33	Olfactory transduction_Homo sapiens_hsa04740	1.02553840
34	Protein export_Homo sapiens_hsa03060	1.00940615
35	Purine metabolism_Homo sapiens_hsa00230	1.00797284
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00397567
37	Regulation of autophagy_Homo sapiens_hsa04140	0.99653125
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.98546982
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89477874
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.87606134
41	Viral myocarditis_Homo sapiens_hsa05416	0.87554786
42	Ether lipid metabolism_Homo sapiens_hsa00565	0.87427616
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.87294873
44	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.87044979
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86345877
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84429235
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.83225875
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.82406900
49	Butanoate metabolism_Homo sapiens_hsa00650	0.82054061
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81529344
51	Parkinsons disease_Homo sapiens_hsa05012	0.78148010
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76906000
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.75580804
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.73127032
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.72739724
56	p53 signaling pathway_Homo sapiens_hsa04115	0.71846546
57	Nicotine addiction_Homo sapiens_hsa05033	0.68578083
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67843912
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67298627
60	Taste transduction_Homo sapiens_hsa04742	0.67020192
61	Leishmaniasis_Homo sapiens_hsa05140	0.66814122
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.64752814
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63710242
64	Morphine addiction_Homo sapiens_hsa05032	0.63425292
65	Alzheimers disease_Homo sapiens_hsa05010	0.63266923
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.61209716
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.61053650
68	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.61037826
69	Salivary secretion_Homo sapiens_hsa04970	0.60459131
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60319836
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57966543
72	RNA transport_Homo sapiens_hsa03013	0.56043299
73	Retinol metabolism_Homo sapiens_hsa00830	0.52090380
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50896263
75	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.49522530
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49374332
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48624502
78	Type II diabetes mellitus_Homo sapiens_hsa04930	0.48237192
79	Huntingtons disease_Homo sapiens_hsa05016	0.47703728
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46850302
81	Ribosome_Homo sapiens_hsa03010	0.45316085
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44534016
83	Renin secretion_Homo sapiens_hsa04924	0.42779008
84	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.42759950
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42225789
86	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.41872337
87	Serotonergic synapse_Homo sapiens_hsa04726	0.41852258
88	Herpes simplex infection_Homo sapiens_hsa05168	0.40580434
89	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.38822072
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38377805
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.37270751
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36731502
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.35773226
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.35604030
95	Circadian rhythm_Homo sapiens_hsa04710	0.35254949
96	Mismatch repair_Homo sapiens_hsa03430	0.31216103
97	Insulin secretion_Homo sapiens_hsa04911	0.30735124
98	Spliceosome_Homo sapiens_hsa03040	0.29940500
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28676623
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.28328630

MTND1P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »