ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.67004548
2	response to pheromone (GO:0019236)	5.08256536
3	L-fucose catabolic process (GO:0042355)	5.08151096
4	fucose catabolic process (GO:0019317)	5.08151096
5	L-fucose metabolic process (GO:0042354)	5.08151096
6	DNA deamination (GO:0045006)	4.06194783
7	ATP synthesis coupled proton transport (GO:0015986)	3.98178542
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.98178542
9	negative regulation of telomere maintenance (GO:0032205)	3.92233408
10	platelet dense granule organization (GO:0060155)	3.89194893
11	positive regulation of action potential (GO:0045760)	3.53100779
12	protein-cofactor linkage (GO:0018065)	3.51076122
13	regulation of action potential (GO:0098900)	3.49159797
14	detection of light stimulus involved in visual perception (GO:0050908)	3.41330704
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.41330704
16	protein neddylation (GO:0045116)	3.38632534
17	kynurenine metabolic process (GO:0070189)	3.37359768
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.28175753
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.25342131
20	epithelial cilium movement (GO:0003351)	3.23083225
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.17250078
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.17250078
23	NADH dehydrogenase complex assembly (GO:0010257)	3.17250078
24	protein complex biogenesis (GO:0070271)	3.15071932
25	indolalkylamine metabolic process (GO:0006586)	3.10938621
26	indole-containing compound catabolic process (GO:0042436)	3.08780787
27	indolalkylamine catabolic process (GO:0046218)	3.08780787
28	tryptophan catabolic process (GO:0006569)	3.08780787
29	cellular ketone body metabolic process (GO:0046950)	3.08529262
30	pyrimidine nucleobase catabolic process (GO:0006208)	3.05528738
31	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.03952538
32	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.03528596
33	positive regulation of amino acid transport (GO:0051957)	3.03353283
34	chaperone-mediated protein transport (GO:0072321)	3.02201197
35	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.00939732
36	positive regulation of organic acid transport (GO:0032892)	3.00674417
37	positive regulation of fatty acid transport (GO:2000193)	2.98819817
38	preassembly of GPI anchor in ER membrane (GO:0016254)	2.98653558
39	piRNA metabolic process (GO:0034587)	2.96838773
40	mitochondrial respiratory chain complex assembly (GO:0033108)	2.94869905
41	protein polyglutamylation (GO:0018095)	2.92957130
42	rRNA catabolic process (GO:0016075)	2.92808218
43	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.88242234
44	mannosylation (GO:0097502)	2.87934050
45	regulation of hexokinase activity (GO:1903299)	2.85741536
46	regulation of glucokinase activity (GO:0033131)	2.85741536
47	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.82910294
48	ketone body metabolic process (GO:1902224)	2.76823233
49	positive regulation of defense response to virus by host (GO:0002230)	2.74379083
50	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.70969690
51	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.70501026
52	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.70501026
53	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.69924175
54	sulfation (GO:0051923)	2.69911901
55	fucosylation (GO:0036065)	2.69418644
56	protein localization to cilium (GO:0061512)	2.69217737
57	DNA methylation involved in gamete generation (GO:0043046)	2.68035278
58	positive regulation of prostaglandin secretion (GO:0032308)	2.66722174
59	gamma-aminobutyric acid transport (GO:0015812)	2.65603263
60	positive regulation of icosanoid secretion (GO:0032305)	2.64988051
61	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.64166131
62	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.62397998
63	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.60778376
64	axoneme assembly (GO:0035082)	2.60412841
65	nucleobase catabolic process (GO:0046113)	2.60238464
66	cornea development in camera-type eye (GO:0061303)	2.59725513
67	regulation of cilium movement (GO:0003352)	2.59491667
68	dopamine transport (GO:0015872)	2.57975889
69	respiratory chain complex IV assembly (GO:0008535)	2.57613355
70	nephron epithelium morphogenesis (GO:0072088)	2.57361406
71	nephron tubule morphogenesis (GO:0072078)	2.57361406
72	regulation of mitotic spindle checkpoint (GO:1903504)	2.56443875
73	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.56443875
74	adaptation of signaling pathway (GO:0023058)	2.54766808
75	neuronal action potential (GO:0019228)	2.54393001
76	kidney morphogenesis (GO:0060993)	2.54058914
77	neural tube formation (GO:0001841)	2.53239472
78	synaptic transmission, cholinergic (GO:0007271)	2.52166079
79	amine catabolic process (GO:0009310)	2.51482585
80	cellular biogenic amine catabolic process (GO:0042402)	2.51482585
81	cAMP catabolic process (GO:0006198)	2.51071525
82	behavioral response to ethanol (GO:0048149)	2.50022371
83	cilium movement (GO:0003341)	2.49342619
84	ubiquinone biosynthetic process (GO:0006744)	2.49239911
85	tryptophan metabolic process (GO:0006568)	2.47941209
86	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.47848623
87	exogenous drug catabolic process (GO:0042738)	2.47828002
88	cytidine metabolic process (GO:0046087)	2.47070025
89	cytidine catabolic process (GO:0006216)	2.47070025
90	cytidine deamination (GO:0009972)	2.47070025
91	nucleotide transmembrane transport (GO:1901679)	2.46642138
92	cilium morphogenesis (GO:0060271)	2.46176428
93	GPI anchor metabolic process (GO:0006505)	2.46087685
94	electron transport chain (GO:0022900)	2.45876986
95	indole-containing compound metabolic process (GO:0042430)	2.45817068
96	nonmotile primary cilium assembly (GO:0035058)	2.45698451
97	negative regulation of heart rate (GO:0010459)	2.45288398
98	negative regulation of mast cell activation (GO:0033004)	2.44503606
99	proton transport (GO:0015992)	2.41262060
100	reflex (GO:0060004)	2.40595217

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.15642002
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.81273011
3	VDR_22108803_ChIP-Seq_LS180_Human	3.36247639
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.67414977
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.56183137
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.48899733
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.39830828
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37672164
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.26156638
10	FUS_26573619_Chip-Seq_HEK293_Human	2.06178948
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04573491
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01882342
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.00400952
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.97410100
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.96661617
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.93780048
17	EWS_26573619_Chip-Seq_HEK293_Human	1.90275458
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88593659
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.87500673
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84204371
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.81824993
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80954563
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.78203680
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77204926
25	P300_19829295_ChIP-Seq_ESCs_Human	1.77112977
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.68676078
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.66899762
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.64108625
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.63038821
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61054380
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.57954212
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56517615
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52782375
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.52782375
35	REST_21632747_ChIP-Seq_MESCs_Mouse	1.52638696
36	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.43622039
37	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.43286768
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.43109653
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43035533
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42833203
41	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40236142
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39955736
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36934061
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.36736950
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.34149068
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32830693
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32544246
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32544246
49	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.30928856
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28932471
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28932471
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28454950
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28360701
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.28360701
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28229844
56	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25939722
57	AR_25329375_ChIP-Seq_VCAP_Human	1.25393763
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.24412875
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24407096
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23398076
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22925664
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.21707937
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.19331641
64	TCF4_23295773_ChIP-Seq_U87_Human	1.18415278
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18154050
66	STAT3_23295773_ChIP-Seq_U87_Human	1.16829981
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.16542474
68	NCOR_22424771_ChIP-Seq_293T_Human	1.14845120
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14314295
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14018806
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13998064
72	VDR_23849224_ChIP-Seq_CD4+_Human	1.12550758
73	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12092309
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10033742
75	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.08740718
76	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.05637552
77	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05562311
78	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.03966392
79	AR_20517297_ChIP-Seq_VCAP_Human	1.03687961
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03660963
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03168580
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02889514
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02488088
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01767508
85	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.00773995
86	MYC_19829295_ChIP-Seq_ESCs_Human	1.00720486
87	ELK1_19687146_ChIP-ChIP_HELA_Human	1.00491210
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00316751
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00137684
90	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.99650952
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99196616
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98156400
93	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96925147
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96246049
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95951015
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.94752730
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93972378
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93842987
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93677815
100	P53_22387025_ChIP-Seq_ESCs_Mouse	0.92633982

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	2.73040916
2	MP0002102_abnormal_ear_morphology	2.39981477
3	MP0008877_abnormal_DNA_methylation	2.39080767
4	MP0004133_heterotaxia	2.36321397
5	MP0005551_abnormal_eye_electrophysiolog	2.35047652
6	MP0006072_abnormal_retinal_apoptosis	2.34513693
7	MP0000569_abnormal_digit_pigmentation	2.30473638
8	MP0004885_abnormal_endolymph	2.30006838
9	MP0006292_abnormal_olfactory_placode	2.27374402
10	MP0003136_yellow_coat_color	2.18391325
11	MP0001986_abnormal_taste_sensitivity	2.15462918
12	MP0004147_increased_porphyrin_level	2.12679320
13	MP0004142_abnormal_muscle_tone	2.03198553
14	MP0002638_abnormal_pupillary_reflex	2.03007663
15	MP0003880_abnormal_central_pattern	1.97831003
16	MP0002653_abnormal_ependyma_morphology	1.97109491
17	MP0003787_abnormal_imprinting	1.96040113
18	MP0001968_abnormal_touch/_nociception	1.95433834
19	MP0002837_dystrophic_cardiac_calcinosis	1.91075518
20	MP0006276_abnormal_autonomic_nervous	1.87792301
21	MP0009745_abnormal_behavioral_response	1.84145450
22	MP0008875_abnormal_xenobiotic_pharmacok	1.80447350
23	MP0002736_abnormal_nociception_after	1.75867222
24	MP0003646_muscle_fatigue	1.75456756
25	MP0002876_abnormal_thyroid_physiology	1.74348442
26	MP0005646_abnormal_pituitary_gland	1.72904647
27	MP0001529_abnormal_vocalization	1.72153716
28	MP0009046_muscle_twitch	1.70942144
29	MP0002272_abnormal_nervous_system	1.70137174
30	MP0002938_white_spotting	1.66833074
31	MP0004043_abnormal_pH_regulation	1.63110869
32	MP0005645_abnormal_hypothalamus_physiol	1.62174266
33	MP0008872_abnormal_physiological_respon	1.59037321
34	MP0005253_abnormal_eye_physiology	1.56047369
35	MP0001485_abnormal_pinna_reflex	1.52885587
36	MP0002735_abnormal_chemical_nociception	1.46850826
37	MP0000631_abnormal_neuroendocrine_gland	1.44949508
38	MP0000427_abnormal_hair_cycle	1.42044735
39	MP0005423_abnormal_somatic_nervous	1.41693958
40	MP0001905_abnormal_dopamine_level	1.41314686
41	MP0002572_abnormal_emotion/affect_behav	1.39438943
42	MP0004742_abnormal_vestibular_system	1.38890061
43	MP0001501_abnormal_sleep_pattern	1.38003707
44	MP0003011_delayed_dark_adaptation	1.35888665
45	MP0002234_abnormal_pharynx_morphology	1.30110761
46	MP0001486_abnormal_startle_reflex	1.29495578
47	MP0005671_abnormal_response_to	1.28493995
48	MP0001984_abnormal_olfaction	1.28071204
49	MP0002095_abnormal_skin_pigmentation	1.26416585
50	MP0005386_behavior/neurological_phenoty	1.26289780
51	MP0004924_abnormal_behavior	1.26289780
52	MP0002064_seizures	1.26237207
53	MP0002557_abnormal_social/conspecific_i	1.25398682
54	MP0002160_abnormal_reproductive_system	1.24237524
55	MP0005174_abnormal_tail_pigmentation	1.20907696
56	MP0005389_reproductive_system_phenotype	1.20785300
57	MP0005195_abnormal_posterior_eye	1.20615924
58	MP0000372_irregular_coat_pigmentation	1.18745131
59	MP0005377_hearing/vestibular/ear_phenot	1.16111293
60	MP0003878_abnormal_ear_physiology	1.16111293
61	MP0003283_abnormal_digestive_organ	1.14688948
62	MP0002063_abnormal_learning/memory/cond	1.13914826
63	MP0009379_abnormal_foot_pigmentation	1.13574713
64	MP0001919_abnormal_reproductive_system	1.13395343
65	MP0000778_abnormal_nervous_system	1.12759209
66	MP0008775_abnormal_heart_ventricle	1.10318781
67	MP0003635_abnormal_synaptic_transmissio	1.09869357
68	MP0002277_abnormal_respiratory_mucosa	1.09651805
69	MP0003121_genomic_imprinting	1.07985931
70	MP0001970_abnormal_pain_threshold	1.05140198
71	MP0002067_abnormal_sensory_capabilities	1.03880158
72	MP0002733_abnormal_thermal_nociception	1.03061169
73	MP0002752_abnormal_somatic_nervous	1.00660659
74	MP0003122_maternal_imprinting	1.00023866
75	MP0001324_abnormal_eye_pigmentation	0.99153294
76	MP0002163_abnormal_gland_morphology	0.97032944
77	MP0001293_anophthalmia	0.95451846
78	MP0002184_abnormal_innervation	0.94737853
79	MP0005084_abnormal_gallbladder_morpholo	0.94040278
80	MP0003718_maternal_effect	0.92230480
81	MP0005075_abnormal_melanosome_morpholog	0.91194758
82	MP0001502_abnormal_circadian_rhythm	0.91151472
83	MP0001188_hyperpigmentation	0.88042588
84	MP0000566_synostosis	0.87546051
85	MP0004145_abnormal_muscle_electrophysio	0.87107588
86	MP0010386_abnormal_urinary_bladder	0.85065613
87	MP0002138_abnormal_hepatobiliary_system	0.84784538
88	MP0000049_abnormal_middle_ear	0.84490879
89	MP0000383_abnormal_hair_follicle	0.82031396
90	MP0000026_abnormal_inner_ear	0.81734276
91	MP0002928_abnormal_bile_duct	0.81186309
92	MP0001963_abnormal_hearing_physiology	0.80797177
93	MP0002229_neurodegeneration	0.80088400
94	MP0002909_abnormal_adrenal_gland	0.80021513
95	MP0002751_abnormal_autonomic_nervous	0.79158401
96	MP0003252_abnormal_bile_duct	0.78843843
97	MP0000955_abnormal_spinal_cord	0.78128685
98	MP0000647_abnormal_sebaceous_gland	0.78101608
99	MP0000230_abnormal_systemic_arterial	0.75875343
100	MP0005379_endocrine/exocrine_gland_phen	0.75238503

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.13621341
2	Abnormality of midbrain morphology (HP:0002418)	4.12056733
3	Molar tooth sign on MRI (HP:0002419)	4.12056733
4	Pancreatic cysts (HP:0001737)	4.11314480
5	Pancreatic fibrosis (HP:0100732)	3.76614293
6	True hermaphroditism (HP:0010459)	3.68137345
7	Nephronophthisis (HP:0000090)	3.46164892
8	Abnormality of the renal cortex (HP:0011035)	3.31979389
9	Congenital, generalized hypertrichosis (HP:0004540)	3.12835954
10	Abnormality of the renal medulla (HP:0100957)	3.00902658
11	Medial flaring of the eyebrow (HP:0010747)	2.88878757
12	Renal cortical cysts (HP:0000803)	2.79774771
13	Type II lissencephaly (HP:0007260)	2.76306347
14	Acute necrotizing encephalopathy (HP:0006965)	2.73849393
15	Abnormality of alanine metabolism (HP:0010916)	2.71242818
16	Hyperalaninemia (HP:0003348)	2.71242818
17	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.71242818
18	Attenuation of retinal blood vessels (HP:0007843)	2.68658590
19	Stomatitis (HP:0010280)	2.66517921
20	Inability to walk (HP:0002540)	2.62751534
21	Polydipsia (HP:0001959)	2.55991648
22	Abnormal drinking behavior (HP:0030082)	2.55991648
23	Pendular nystagmus (HP:0012043)	2.55819136
24	Mitochondrial inheritance (HP:0001427)	2.53182974
25	Cystic liver disease (HP:0006706)	2.52562965
26	Abnormal biliary tract physiology (HP:0012439)	2.51586357
27	Bile duct proliferation (HP:0001408)	2.51586357
28	Acute encephalopathy (HP:0006846)	2.48376300
29	Increased CSF lactate (HP:0002490)	2.48090674
30	Tubular atrophy (HP:0000092)	2.47594923
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.47215497
32	Abolished electroretinogram (ERG) (HP:0000550)	2.40391446
33	3-Methylglutaconic aciduria (HP:0003535)	2.40113261
34	Chronic hepatic failure (HP:0100626)	2.39881555
35	Abnormal number of erythroid precursors (HP:0012131)	2.38133769
36	Progressive macrocephaly (HP:0004481)	2.37385341
37	Limb dystonia (HP:0002451)	2.34114024
38	Abnormal mitochondria in muscle tissue (HP:0008316)	2.31684127
39	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.30723247
40	Absent/shortened dynein arms (HP:0200106)	2.30723247
41	Abnormality of cells of the erythroid lineage (HP:0012130)	2.27918613
42	Sclerocornea (HP:0000647)	2.26826205
43	Polyuria (HP:0000103)	2.26477595
44	Progressive inability to walk (HP:0002505)	2.26473696
45	Bilateral microphthalmos (HP:0007633)	2.24312643
46	Gait imbalance (HP:0002141)	2.24242982
47	Optic disc pallor (HP:0000543)	2.21189010
48	Hypoplasia of the fovea (HP:0007750)	2.21024868
49	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.21024868
50	Methylmalonic acidemia (HP:0002912)	2.18070266
51	Hyperglycinemia (HP:0002154)	2.15215447
52	Decreased circulating renin level (HP:0003351)	2.14937441
53	Lissencephaly (HP:0001339)	2.14546641
54	Congenital primary aphakia (HP:0007707)	2.13309585
55	Decreased central vision (HP:0007663)	2.13017643
56	Lipid accumulation in hepatocytes (HP:0006561)	2.10060289
57	Nephrogenic diabetes insipidus (HP:0009806)	2.09833803
58	Hypothermia (HP:0002045)	2.09692626
59	Concave nail (HP:0001598)	2.04036926
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01885859
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.00242082
62	Metabolic alkalosis (HP:0200114)	1.98516747
63	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.97762318
64	Pachygyria (HP:0001302)	1.97666423
65	Congenital hepatic fibrosis (HP:0002612)	1.96892268
66	Increased corneal curvature (HP:0100692)	1.96869949
67	Keratoconus (HP:0000563)	1.96869949
68	Cerebellar dysplasia (HP:0007033)	1.96202456
69	Increased hepatocellular lipid droplets (HP:0006565)	1.95688820
70	Male pseudohermaphroditism (HP:0000037)	1.94126410
71	Abnormal respiratory epithelium morphology (HP:0012253)	1.92745281
72	Abnormal respiratory motile cilium morphology (HP:0005938)	1.92745281
73	Hyperglycinuria (HP:0003108)	1.91165048
74	Postaxial foot polydactyly (HP:0001830)	1.90939217
75	Hyperventilation (HP:0002883)	1.90929002
76	Optic nerve hypoplasia (HP:0000609)	1.90186372
77	Tachypnea (HP:0002789)	1.88294019
78	Hepatocellular necrosis (HP:0001404)	1.87927549
79	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85681539
80	Broad-based gait (HP:0002136)	1.83787696
81	Asplenia (HP:0001746)	1.83093979
82	Hepatic necrosis (HP:0002605)	1.82492127
83	Methylmalonic aciduria (HP:0012120)	1.82159116
84	Genital tract atresia (HP:0001827)	1.80689277
85	Vaginal atresia (HP:0000148)	1.79998926
86	Abnormal urine output (HP:0012590)	1.79876324
87	Anencephaly (HP:0002323)	1.79831642
88	Furrowed tongue (HP:0000221)	1.79634833
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79403068
90	Absent thumb (HP:0009777)	1.78931238
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.77731866
92	Abnormality of the fovea (HP:0000493)	1.75841923
93	Short tibia (HP:0005736)	1.75054347
94	Rib fusion (HP:0000902)	1.75017692
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73306491
96	Hypoalbuminemia (HP:0003073)	1.72876458
97	Abnormal albumin level (HP:0012116)	1.72876458
98	Ketosis (HP:0001946)	1.71154903
99	Abnormal ciliary motility (HP:0012262)	1.70910769
100	Postaxial hand polydactyly (HP:0001162)	1.70782402

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.91338905
2	ADRBK2	3.64839961
3	PINK1	2.89078177
4	WNK4	2.79594201
5	WNK3	2.76710066
6	TXK	2.74525303
7	TLK1	2.70575326
8	BMPR1B	2.45439406
9	GRK1	2.40630141
10	ZAK	2.38779015
11	TAOK3	2.28500157
12	MAP4K2	2.06405975
13	PNCK	1.96038360
14	NUAK1	1.88691919
15	CASK	1.83877664
16	TNIK	1.72014193
17	MAPK13	1.68890503
18	INSRR	1.67156653
19	DAPK2	1.65430192
20	BCKDK	1.58377399
21	MARK1	1.57581535
22	TRIM28	1.38152032
23	DYRK2	1.38091576
24	OXSR1	1.33531938
25	MAP3K4	1.32425614
26	NTRK3	1.25824317
27	ADRBK1	1.18953713
28	PRKCG	1.17360278
29	ACVR1B	1.14495220
30	PRKCE	1.09742357
31	MAP2K7	1.03655895
32	PHKG2	1.03294615
33	PHKG1	1.03294615
34	MAP2K2	1.01935708
35	VRK1	1.00393086
36	STK39	0.97883470
37	MKNK2	0.97035062
38	TGFBR1	0.93775889
39	PLK2	0.92608645
40	FES	0.85979553
41	PAK3	0.85482287
42	SIK2	0.84415159
43	FLT3	0.79785400
44	TAF1	0.76717054
45	MAP2K6	0.75269646
46	PRKCI	0.74354530
47	NTRK2	0.74321453
48	KIT	0.74204900
49	PIK3CA	0.73571357
50	IKBKB	0.72258535
51	TEC	0.72033602
52	TIE1	0.70946609
53	PLK4	0.70273470
54	MUSK	0.69064582
55	FGFR2	0.68865425
56	CDK19	0.68197294
57	ERBB3	0.68125280
58	BCR	0.65194159
59	PRKCQ	0.63823771
60	ITK	0.63087127
61	CSNK1G2	0.60501340
62	PTK2B	0.58298927
63	CSNK1G1	0.57007706
64	CAMK1	0.56861059
65	CDK8	0.55696349
66	PRKCH	0.54236483
67	MAPKAPK5	0.53961006
68	NEK1	0.53939033
69	PKN1	0.53487882
70	PRKACA	0.53400460
71	RPS6KA5	0.52290304
72	RPS6KA6	0.51926167
73	CAMK2A	0.51662223
74	MAP3K12	0.49120647
75	IRAK1	0.49091741
76	STK38L	0.47320745
77	CSNK1G3	0.47241999
78	CHUK	0.47162415
79	MKNK1	0.46839339
80	MINK1	0.46399296
81	CSNK1A1	0.45271691
82	PRKCA	0.43315304
83	MAP2K1	0.43069122
84	GRK7	0.41502735
85	MAPK15	0.41231805
86	MATK	0.39664306
87	STK16	0.39335493
88	SYK	0.39028103
89	NME1	0.38712311
90	MAP2K4	0.38682916
91	VRK2	0.38282471
92	STK11	0.37976337
93	MST4	0.37909340
94	PLK3	0.37486963
95	PRKCZ	0.37030845
96	CSNK1A1L	0.35713920
97	SGK494	0.35225108
98	SGK223	0.35225108
99	NLK	0.34942342
100	PRKG1	0.32439090

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.98892575
2	Phototransduction_Homo sapiens_hsa04744	2.62463586
3	Parkinsons disease_Homo sapiens_hsa05012	2.52150138
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.43884057
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33223540
6	Protein export_Homo sapiens_hsa03060	2.24660830
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.15501143
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14286830
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.14261112
10	Caffeine metabolism_Homo sapiens_hsa00232	2.08462032
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03264002
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.02890813
13	Nicotine addiction_Homo sapiens_hsa05033	1.98259463
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.97975351
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.95130491
16	Butanoate metabolism_Homo sapiens_hsa00650	1.94947247
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.90252856
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.89582675
19	Ribosome_Homo sapiens_hsa03010	1.85985831
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.80498659
21	Basal transcription factors_Homo sapiens_hsa03022	1.77864748
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.75721410
23	Homologous recombination_Homo sapiens_hsa03440	1.74638244
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.68863555
25	RNA polymerase_Homo sapiens_hsa03020	1.65954131
26	Alzheimers disease_Homo sapiens_hsa05010	1.62697419
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.61136982
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.59594950
29	Huntingtons disease_Homo sapiens_hsa05016	1.51234040
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.43859851
31	Taste transduction_Homo sapiens_hsa04742	1.40041633
32	RNA degradation_Homo sapiens_hsa03018	1.37059671
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.29508794
34	Morphine addiction_Homo sapiens_hsa05032	1.27131204
35	Peroxisome_Homo sapiens_hsa04146	1.26068528
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.21780301
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.20711167
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19783407
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18241829
40	GABAergic synapse_Homo sapiens_hsa04727	1.16421162
41	Olfactory transduction_Homo sapiens_hsa04740	1.16118397
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.09226558
43	Regulation of autophagy_Homo sapiens_hsa04140	1.08250272
44	Sulfur metabolism_Homo sapiens_hsa00920	1.04933022
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04794293
46	Asthma_Homo sapiens_hsa05310	0.96906456
47	Propanoate metabolism_Homo sapiens_hsa00640	0.93904277
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93729176
49	Insulin secretion_Homo sapiens_hsa04911	0.93489731
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.91270765
51	Proteasome_Homo sapiens_hsa03050	0.91194943
52	Retinol metabolism_Homo sapiens_hsa00830	0.90009781
53	Serotonergic synapse_Homo sapiens_hsa04726	0.88247965
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86640451
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85367383
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82819864
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.80265707
58	Circadian entrainment_Homo sapiens_hsa04713	0.79863402
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.75924413
60	Type I diabetes mellitus_Homo sapiens_hsa04940	0.75775432
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.74680768
62	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.73360758
63	One carbon pool by folate_Homo sapiens_hsa00670	0.72483999
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.72326831
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71014734
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.70963716
67	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.69584094
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69229528
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66794859
70	Purine metabolism_Homo sapiens_hsa00230	0.66338547
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.65256677
72	Allograft rejection_Homo sapiens_hsa05330	0.64579071
73	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.62924460
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60668020
75	Metabolic pathways_Homo sapiens_hsa01100	0.60463637
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59191594
77	ABC transporters_Homo sapiens_hsa02010	0.57977595
78	Histidine metabolism_Homo sapiens_hsa00340	0.57041716
79	Sulfur relay system_Homo sapiens_hsa04122	0.56281775
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55153026
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.54958245
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53971994
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52878456
84	Mineral absorption_Homo sapiens_hsa04978	0.52744250
85	Graft-versus-host disease_Homo sapiens_hsa05332	0.52506049
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52094048
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50877992
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49080880
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47576715
90	Circadian rhythm_Homo sapiens_hsa04710	0.47090319
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45697678
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.44402135
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44200007
94	Steroid biosynthesis_Homo sapiens_hsa00100	0.44104497
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42572350
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41471349
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.40165324
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37583926
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36206179
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.33667086

MTND2P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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