MTND2P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle tissue regeneration (GO:0043403)6.07787377
2fat-soluble vitamin catabolic process (GO:0042363)5.95954922
3vitamin catabolic process (GO:0009111)5.95954922
4regulation of female receptivity (GO:0045924)5.62395904
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.49378652
6ATP synthesis coupled proton transport (GO:0015986)5.49378652
7mature B cell differentiation involved in immune response (GO:0002313)5.42575856
8negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.28439785
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.07809777
10DNA deamination (GO:0045006)4.98317407
11female mating behavior (GO:0060180)4.76464039
12urate metabolic process (GO:0046415)4.30470609
13detection of light stimulus involved in sensory perception (GO:0050962)4.16342075
14detection of light stimulus involved in visual perception (GO:0050908)4.16342075
15positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.10228680
16GTP biosynthetic process (GO:0006183)4.08434444
17regulation of germinal center formation (GO:0002634)4.05725562
18regulation of mesoderm development (GO:2000380)4.03238896
19indolalkylamine metabolic process (GO:0006586)3.99127320
20regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.95637001
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.89835970
22synaptic transmission, dopaminergic (GO:0001963)3.66500103
23protein targeting to lysosome (GO:0006622)3.65377220
24establishment of protein localization to vacuole (GO:0072666)3.65377220
25protein targeting to vacuole (GO:0006623)3.65377220
26collecting duct development (GO:0072044)3.63841147
27protein complex biogenesis (GO:0070271)3.62892163
28mature B cell differentiation (GO:0002335)3.60849286
29tryptophan metabolic process (GO:0006568)3.58968717
30mitochondrial respiratory chain complex assembly (GO:0033108)3.58784817
31UTP biosynthetic process (GO:0006228)3.51649225
32purine ribonucleotide transport (GO:0015868)3.51344082
33purine nucleoside triphosphate biosynthetic process (GO:0009145)3.50313636
34purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.49365690
35tryptophan catabolic process (GO:0006569)3.48123408
36indole-containing compound catabolic process (GO:0042436)3.48123408
37indolalkylamine catabolic process (GO:0046218)3.48123408
38respiratory electron transport chain (GO:0022904)3.47676373
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47396827
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.47396827
41NADH dehydrogenase complex assembly (GO:0010257)3.47396827
42electron transport chain (GO:0022900)3.43680294
43respiratory chain complex IV assembly (GO:0008535)3.39972676
44kynurenine metabolic process (GO:0070189)3.38769828
45regulation of glomerulus development (GO:0090192)3.37013700
46adenine nucleotide transport (GO:0051503)3.34009694
47oxidative phosphorylation (GO:0006119)3.31324203
48ATP biosynthetic process (GO:0006754)3.30712400
49neuronal action potential (GO:0019228)3.30266744
50UTP metabolic process (GO:0046051)3.28702596
51sleep (GO:0030431)3.26670279
52cellular glucuronidation (GO:0052695)3.26452742
53behavioral response to nicotine (GO:0035095)3.24129416
54activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.19744746
55Peyers patch development (GO:0048541)3.18050038
56mucosal-associated lymphoid tissue development (GO:0048537)3.18050038
57protein localization to lysosome (GO:0061462)3.14762112
58protein localization to vacuole (GO:0072665)3.14762112
59phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.12838909
60cytochrome complex assembly (GO:0017004)3.12441669
61positive regulation of glomerulus development (GO:0090193)3.12042744
62hydrogen ion transmembrane transport (GO:1902600)3.08963921
63negative regulation of thymocyte apoptotic process (GO:0070244)3.08537318
64negative regulation of transcription regulatory region DNA binding (GO:2000678)3.04609096
65L-fucose catabolic process (GO:0042355)3.03811696
66fucose catabolic process (GO:0019317)3.03811696
67L-fucose metabolic process (GO:0042354)3.03811696
68glucuronate metabolic process (GO:0019585)3.03273165
69uronic acid metabolic process (GO:0006063)3.03273165
70disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.03016153
71killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.03016153
72rRNA modification (GO:0000154)3.02044835
73primary amino compound metabolic process (GO:1901160)2.98384374
74ribonucleoside triphosphate biosynthetic process (GO:0009201)2.98367630
75indole-containing compound metabolic process (GO:0042430)2.97911854
76detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.94417451
77lipoxygenase pathway (GO:0019372)2.92933998
78response to xenobiotic stimulus (GO:0009410)2.92441185
79negative regulation of B cell apoptotic process (GO:0002903)2.90450998
80positive regulation of osteoblast proliferation (GO:0033690)2.83236381
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83218807
82regulation of inositol phosphate biosynthetic process (GO:0010919)2.81341171
83adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.79684392
84positive regulation of cAMP-mediated signaling (GO:0043950)2.78640830
85regulation of memory T cell differentiation (GO:0043380)2.76537965
86cornea development in camera-type eye (GO:0061303)2.76013035
87positive regulation of T cell differentiation in thymus (GO:0033089)2.75307361
88negative regulation of oxidoreductase activity (GO:0051354)2.75061806
89positive regulation of calcium-mediated signaling (GO:0050850)2.72545037
90regulation of triglyceride catabolic process (GO:0010896)2.71486332
91nonmotile primary cilium assembly (GO:0035058)2.71223742
92B cell activation involved in immune response (GO:0002312)2.70820397
93regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.68402852
94serotonin metabolic process (GO:0042428)2.67469122
95proton transport (GO:0015992)2.65807482
96hydrogen transport (GO:0006818)2.65584280
97nucleoside triphosphate biosynthetic process (GO:0009142)2.64304854
98CTP metabolic process (GO:0046036)2.63017029
99CTP biosynthetic process (GO:0006241)2.63017029
100purine nucleotide transport (GO:0015865)2.62429413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.06781166
2VDR_22108803_ChIP-Seq_LS180_Human2.92904218
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.82566789
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61594617
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.57910798
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24389929
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.23604602
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21319405
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18425233
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15512027
11EWS_26573619_Chip-Seq_HEK293_Human1.97682737
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96546622
13GBX2_23144817_ChIP-Seq_PC3_Human1.93931922
14GABP_17652178_ChIP-ChIP_JURKAT_Human1.91948687
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91885253
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.84981745
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84764135
18P300_19829295_ChIP-Seq_ESCs_Human1.81860545
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79381556
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78803633
21TP53_22573176_ChIP-Seq_HFKS_Human1.69383632
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65974260
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62282412
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61782059
25AUTS2_25519132_ChIP-Seq_293T-REX_Human1.61554071
26ZNF274_21170338_ChIP-Seq_K562_Hela1.58484724
27FUS_26573619_Chip-Seq_HEK293_Human1.56351683
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55134670
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.51451885
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44827693
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44686428
32NCOR_22424771_ChIP-Seq_293T_Human1.44067889
33BCAT_22108803_ChIP-Seq_LS180_Human1.42865137
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42542272
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.42415940
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.39703385
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.39437300
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35118778
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33868458
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.33612359
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33550927
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33387617
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.33073959
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33058301
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32444600
46MYC_18940864_ChIP-ChIP_HL60_Human1.30419679
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.30310366
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30310366
49P53_21459846_ChIP-Seq_SAOS-2_Human1.29414803
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29194110
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29170025
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28963648
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28852427
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27203522
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26718758
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26200348
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24420875
58SOX2_19829295_ChIP-Seq_ESCs_Human1.24011252
59NANOG_19829295_ChIP-Seq_ESCs_Human1.24011252
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.23292752
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21836777
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21836777
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21836777
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21608438
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21465121
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.20844444
67AR_25329375_ChIP-Seq_VCAP_Human1.20691267
68ELK1_19687146_ChIP-ChIP_HELA_Human1.19504081
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19396466
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18789525
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18713651
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18592999
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18400989
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18400989
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18342010
76RNF2_27304074_Chip-Seq_NSC_Mouse1.17710648
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16474032
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14746870
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14152886
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13864774
81P53_22387025_ChIP-Seq_ESCs_Mouse1.12925886
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12535559
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.11703191
84VDR_23849224_ChIP-Seq_CD4+_Human1.11587171
85SMAD4_21799915_ChIP-Seq_A2780_Human1.11388831
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11371712
87CBP_20019798_ChIP-Seq_JUKART_Human1.11371712
88ETV1_20927104_ChIP-Seq_GIST48_Human1.10775916
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.09596806
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.09526864
91FOXH1_21741376_ChIP-Seq_EPCs_Human1.06168171
92ER_23166858_ChIP-Seq_MCF-7_Human1.05751701
93RUNX2_22187159_ChIP-Seq_PCA_Human1.05745265
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05693882
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05432386
96TAF2_19829295_ChIP-Seq_ESCs_Human1.05147835
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03352890
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01676401
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.00956237
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00742794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.07673966
2MP0005360_urolithiasis4.43033968
3MP0002736_abnormal_nociception_after4.19866685
4MP0000678_abnormal_parathyroid_gland3.81487932
5MP0001968_abnormal_touch/_nociception3.49370295
6MP0002132_abnormal_respiratory_system3.38779921
7MP0002163_abnormal_gland_morphology3.29040765
8MP0009697_abnormal_copulation2.90527783
9MP0005646_abnormal_pituitary_gland2.76362346
10MP0005379_endocrine/exocrine_gland_phen2.66295234
11MP0008872_abnormal_physiological_respon2.41342726
12MP0003011_delayed_dark_adaptation2.31045053
13MP0001346_abnormal_lacrimal_gland2.29730653
14MP0002734_abnormal_mechanical_nocicepti2.15228357
15MP0002909_abnormal_adrenal_gland2.11254701
16MP0006276_abnormal_autonomic_nervous2.08291755
17MP0003283_abnormal_digestive_organ1.99490831
18MP0006292_abnormal_olfactory_placode1.92028026
19MP0001905_abnormal_dopamine_level1.83477681
20MP0003938_abnormal_ear_development1.82765359
21MP0002277_abnormal_respiratory_mucosa1.78048363
22MP0000049_abnormal_middle_ear1.72600065
23MP0001984_abnormal_olfaction1.63894972
24MP0003195_calcinosis1.56042932
25MP0010386_abnormal_urinary_bladder1.53550416
26MP0006072_abnormal_retinal_apoptosis1.50754236
27MP0002735_abnormal_chemical_nociception1.48012747
28MP0005671_abnormal_response_to1.46573709
29MP0003646_muscle_fatigue1.40022577
30MP0006036_abnormal_mitochondrial_physio1.39368706
31MP0009053_abnormal_anal_canal1.32824309
32MP0001879_abnormal_lymphatic_vessel1.27118054
33MP0009379_abnormal_foot_pigmentation1.26118425
34MP0009840_abnormal_foam_cell1.25921614
35MP0003959_abnormal_lean_body1.23472199
36MP0005551_abnormal_eye_electrophysiolog1.21051775
37MP0002282_abnormal_trachea_morphology1.19992687
38MP0003724_increased_susceptibility_to1.14826224
39MP0005253_abnormal_eye_physiology1.14524279
40MP0000631_abnormal_neuroendocrine_gland1.10490437
41MP0002837_dystrophic_cardiac_calcinosis1.10372991
42MP0001970_abnormal_pain_threshold1.08754298
43MP0005083_abnormal_biliary_tract1.08314656
44MP0009333_abnormal_splenocyte_physiolog1.08198651
45MP0002876_abnormal_thyroid_physiology1.06782432
46MP0000538_abnormal_urinary_bladder1.01028220
47MP0000613_abnormal_salivary_gland1.00383015
48MP0005645_abnormal_hypothalamus_physiol0.99341823
49MP0002572_abnormal_emotion/affect_behav0.99226631
50MP0001765_abnormal_ion_homeostasis0.98433834
51MP0002233_abnormal_nose_morphology0.97678024
52MP0002272_abnormal_nervous_system0.96808073
53MP0005636_abnormal_mineral_homeostasis0.95162096
54MP0004019_abnormal_vitamin_homeostasis0.94935750
55MP0002249_abnormal_larynx_morphology0.94161894
56MP0002148_abnormal_hypersensitivity_rea0.93297702
57MP0004885_abnormal_endolymph0.90218128
58MP0001529_abnormal_vocalization0.90122304
59MP0001502_abnormal_circadian_rhythm0.89774879
60MP0003937_abnormal_limbs/digits/tail_de0.89366034
61MP0000026_abnormal_inner_ear0.89299546
62MP0009046_muscle_twitch0.88231118
63MP0009745_abnormal_behavioral_response0.87274528
64MP0002234_abnormal_pharynx_morphology0.84570562
65MP0002102_abnormal_ear_morphology0.83457938
66MP0000372_irregular_coat_pigmentation0.83367868
67MP0003119_abnormal_digestive_system0.82903621
68MP0004215_abnormal_myocardial_fiber0.81397879
69MP0005000_abnormal_immune_tolerance0.76825398
70MP0002160_abnormal_reproductive_system0.75856556
71MP0009764_decreased_sensitivity_to0.75605232
72MP0008877_abnormal_DNA_methylation0.74291655
73MP0003252_abnormal_bile_duct0.73844503
74MP0000647_abnormal_sebaceous_gland0.72388312
75MP0003136_yellow_coat_color0.71103588
76MP0001835_abnormal_antigen_presentation0.69541353
77MP0002006_tumorigenesis0.68528528
78MP0004381_abnormal_hair_follicle0.67128768
79MP0010329_abnormal_lipoprotein_level0.66256042
80MP0009785_altered_susceptibility_to0.65931709
81MP0001286_abnormal_eye_development0.65657697
82MP0000537_abnormal_urethra_morphology0.62910027
83MP0001963_abnormal_hearing_physiology0.62076193
84MP0004085_abnormal_heartbeat0.61220435
85MP0002733_abnormal_thermal_nociception0.59331963
86MP0004742_abnormal_vestibular_system0.59259164
87MP0003718_maternal_effect0.58345390
88MP0002638_abnormal_pupillary_reflex0.57354998
89MP0001661_extended_life_span0.57348329
90MP0002938_white_spotting0.56805894
91MP0009643_abnormal_urine_homeostasis0.56669049
92MP0008789_abnormal_olfactory_epithelium0.56631846
93MP0000230_abnormal_systemic_arterial0.56594110
94MP0002557_abnormal_social/conspecific_i0.55798336
95MP0001800_abnormal_humoral_immune0.54798493
96MP0009250_abnormal_appendicular_skeleto0.54527643
97MP0005389_reproductive_system_phenotype0.53944479
98MP0001764_abnormal_homeostasis0.52947928
99MP0008770_decreased_survivor_rate0.52709842
100MP0002933_joint_inflammation0.52560554

Predicted human phenotypes

RankGene SetZ-score
1Short middle phalanx of the 5th finger (HP:0004220)5.34002704
2Abnormality of the middle phalanx of the 5th finger (HP:0004219)5.16564898
3Abnormality of the phalanges of the 5th finger (HP:0004213)4.87387559
4Poor head control (HP:0002421)4.61670244
5Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.14994450
6Abolished electroretinogram (ERG) (HP:0000550)4.11376237
7Absent/shortened dynein arms (HP:0200106)3.93630591
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.93630591
9Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.89418425
10Abnormality of aspartate family amino acid metabolism (HP:0010899)3.40103243
11Bony spicule pigmentary retinopathy (HP:0007737)3.32590522
12Abnormality of cochlea (HP:0000375)3.32289980
13Decreased central vision (HP:0007663)3.28064631
14Keratoconjunctivitis sicca (HP:0001097)3.26171334
15Keratoconjunctivitis (HP:0001096)3.12742036
16Decreased electroretinogram (ERG) amplitude (HP:0000654)3.12602579
17Morphological abnormality of the middle ear (HP:0008609)3.12492215
18Abnormality of the costochondral junction (HP:0000919)3.08515181
19Dysautonomia (HP:0002459)3.06969180
20Attenuation of retinal blood vessels (HP:0007843)3.01100551
21Progressive macrocephaly (HP:0004481)2.97220246
22Acute necrotizing encephalopathy (HP:0006965)2.93585917
23Hepatocellular necrosis (HP:0001404)2.90517109
24Absent phalangeal crease (HP:0006109)2.86167215
25Follicular hyperkeratosis (HP:0007502)2.83813524
26Abnormal respiratory motile cilium morphology (HP:0005938)2.66182419
27Abnormal respiratory epithelium morphology (HP:0012253)2.66182419
28Mitochondrial inheritance (HP:0001427)2.63705229
29Abnormal mitochondria in muscle tissue (HP:0008316)2.62433056
30Increased CSF lactate (HP:0002490)2.61844629
31Keratoconus (HP:0000563)2.60508862
32Increased corneal curvature (HP:0100692)2.60508862
333-Methylglutaconic aciduria (HP:0003535)2.55093484
34Thyroiditis (HP:0100646)2.54629189
35Generalized aminoaciduria (HP:0002909)2.54406282
36Petechiae (HP:0000967)2.53753177
37Abnormal ciliary motility (HP:0012262)2.51708711
38Morphological abnormality of the inner ear (HP:0011390)2.50094738
39Enlarged epiphyses (HP:0010580)2.47197220
40Abnormality of the proximal phalanges of the hand (HP:0009834)2.44230401
41Severe combined immunodeficiency (HP:0004430)2.42334442
42Hepatic necrosis (HP:0002605)2.40224890
43Congenital stationary night blindness (HP:0007642)2.38911480
44Long nose (HP:0003189)2.33314055
45Abnormal finger flexion creases (HP:0006143)2.32296743
46Mesangial abnormality (HP:0001966)2.31745169
47Tinnitus (HP:0000360)2.31261771
48Ulnar deviation of the wrist (HP:0003049)2.29254386
49Testicular atrophy (HP:0000029)2.28894940
50Short 5th finger (HP:0009237)2.20073212
51Symptomatic seizures (HP:0011145)2.19728776
52Acanthocytosis (HP:0001927)2.13036165
53Nonimmune hydrops fetalis (HP:0001790)2.12638610
54Acute encephalopathy (HP:0006846)2.11237087
55Symphalangism affecting the phalanges of the hand (HP:0009773)2.09715766
56Abnormality of the renal collecting system (HP:0004742)2.09100786
57Congenital, generalized hypertrichosis (HP:0004540)2.08088197
58Constricted visual fields (HP:0001133)2.07888947
59Abnormal respiratory motile cilium physiology (HP:0012261)2.06578717
60Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.06477928
61Homocystinuria (HP:0002156)2.03819488
62Abnormality of homocysteine metabolism (HP:0010919)2.03819488
63Abnormality of macular pigmentation (HP:0008002)2.02230325
64Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98317320
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98317320
66Abnormality of dental color (HP:0011073)1.89057804
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88679016
68IgG deficiency (HP:0004315)1.87854939
69Delayed epiphyseal ossification (HP:0002663)1.84875394
70Abnormality of serum amino acid levels (HP:0003112)1.84319808
71Pendular nystagmus (HP:0012043)1.83307109
72Absent eyebrow (HP:0002223)1.82069010
73Abnormality of the middle phalanges of the toes (HP:0010183)1.81927709
74Macrocytic anemia (HP:0001972)1.79952238
75Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.79427359
76Cerebral edema (HP:0002181)1.79096670
77Methylmalonic acidemia (HP:0002912)1.78971144
78Autoimmune thrombocytopenia (HP:0001973)1.77377968
79Abnormality of the nasal septum (HP:0000419)1.77001079
80Methylmalonic aciduria (HP:0012120)1.76857076
81Failure to thrive in infancy (HP:0001531)1.75422788
82Abnormal autonomic nervous system physiology (HP:0012332)1.74418780
83Abnormality of the renal cortex (HP:0011035)1.71517851
84Pancreatic cysts (HP:0001737)1.70520195
85Large for gestational age (HP:0001520)1.70487434
86Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68330591
87Combined immunodeficiency (HP:0005387)1.68123830
88Hamartoma of the eye (HP:0010568)1.67700718
89Abnormality of the prostate (HP:0008775)1.67661507
90Rib fusion (HP:0000902)1.67303374
91Lymphangioma (HP:0100764)1.66037195
92Hypoplasia of the uterus (HP:0000013)1.65961322
93Mesomelia (HP:0003027)1.64082307
94Anterior segment dysgenesis (HP:0007700)1.63986706
95Progressive microcephaly (HP:0000253)1.63634214
96B lymphocytopenia (HP:0010976)1.59802658
97Hypothermia (HP:0002045)1.58879111
98Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.58086051
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.57941797
100Hyperalaninemia (HP:0003348)1.57941797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.46413929
2STK162.88911939
3TAOK32.82581194
4ZAK2.82544650
5GRK12.39178361
6NUAK12.36891053
7ADRBK22.30281649
8CDK122.19202751
9MAP2K22.15709890
10SIK21.99651556
11PDK21.99273754
12CDK81.86979993
13PKN11.85949371
14TXK1.84895724
15MST41.77970657
16CDK41.72102757
17BRSK21.70664449
18PIK3CG1.69742081
19BMPR1B1.68319296
20IRAK41.60265904
21SMG11.55276061
22KIT1.47283565
23INSRR1.47031804
24CHEK21.40014571
25TEC1.35131951
26CDK191.34348319
27MYLK1.22646428
28EPHA41.21148158
29MAP4K21.19821745
30VRK21.18248758
31OXSR11.16929489
32TSSK61.16736321
33NTRK21.15230067
34CSF1R1.12375227
35CDC71.11914085
36MATK1.10441543
37WNK41.09026573
38PHKG11.06639964
39PHKG21.06639964
40MAPK131.05297248
41OBSCN1.03742611
42MAPKAPK30.95314313
43CAMK10.92786986
44TLK10.92641788
45FLT30.88892416
46CSNK1G20.87153013
47ERBB30.84154783
48IKBKB0.83697354
49MAPKAPK50.83245581
50RPS6KA50.82737330
51TRPM70.81822025
52JAK30.81236644
53MAP3K40.80745077
54CAMKK20.78972391
55CSNK1G30.78924947
56ERBB20.77990196
57WNK30.77099774
58STK380.76710680
59STK390.74487564
60CSNK1G10.74411119
61ADRBK10.74067801
62IKBKE0.73316283
63LMTK20.71414137
64ILK0.71236345
65ITK0.70689858
66PLK30.68394689
67TIE10.64670102
68IGF1R0.63386315
69PRKCA0.62088989
70MAP2K10.61523807
71PRKCE0.61323155
72IRAK10.61097134
73PRKACA0.60171059
74PRKD10.59146501
75AURKA0.58550075
76PRKCZ0.57563367
77DAPK10.56539664
78SYK0.55019577
79PIK3CA0.53920174
80LCK0.53365214
81NME20.52792810
82MAPK40.51796103
83CSNK1A1L0.51630911
84PRKG10.51233876
85PRKCG0.50921723
86EIF2AK30.50799881
87CAMK2B0.49673981
88MUSK0.48205545
89ATR0.47463051
90DAPK30.47381301
91PINK10.47032431
92MAP3K70.45949292
93VRK10.45316702
94RPS6KA60.45221604
95BMPR20.44821900
96PRKCQ0.41673123
97CAMK2A0.41344974
98PAK20.40512129
99AURKB0.40254780
100PRKACG0.40197769

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.35964287
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.17596114
3Oxidative phosphorylation_Homo sapiens_hsa001902.98691581
4Parkinsons disease_Homo sapiens_hsa050122.51249206
5Retinol metabolism_Homo sapiens_hsa008302.29824861
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28913186
7Ribosome_Homo sapiens_hsa030102.22642008
8Olfactory transduction_Homo sapiens_hsa047402.22612728
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.20364334
10Sulfur relay system_Homo sapiens_hsa041222.18658201
11Protein export_Homo sapiens_hsa030602.10079586
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07861985
13Chemical carcinogenesis_Homo sapiens_hsa052042.04234439
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.99426173
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89117027
16One carbon pool by folate_Homo sapiens_hsa006701.87190125
17Phototransduction_Homo sapiens_hsa047441.87035475
18Asthma_Homo sapiens_hsa053101.86565660
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.83838499
20Alzheimers disease_Homo sapiens_hsa050101.77399863
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.76450923
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.75819919
23Homologous recombination_Homo sapiens_hsa034401.63833114
24Starch and sucrose metabolism_Homo sapiens_hsa005001.60347004
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.47410258
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44207378
27Primary immunodeficiency_Homo sapiens_hsa053401.42867920
28Selenocompound metabolism_Homo sapiens_hsa004501.41124543
29Arachidonic acid metabolism_Homo sapiens_hsa005901.39288562
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37499191
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36500189
32Nitrogen metabolism_Homo sapiens_hsa009101.36078836
33Collecting duct acid secretion_Homo sapiens_hsa049661.33199820
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31146941
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28531925
36Proteasome_Homo sapiens_hsa030501.25692345
37Tryptophan metabolism_Homo sapiens_hsa003801.24961953
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24522445
39Cardiac muscle contraction_Homo sapiens_hsa042601.23490295
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22333986
41Huntingtons disease_Homo sapiens_hsa050161.21490184
42Nicotine addiction_Homo sapiens_hsa050331.19620579
43Allograft rejection_Homo sapiens_hsa053301.16266267
44Rheumatoid arthritis_Homo sapiens_hsa053231.14779708
45Type I diabetes mellitus_Homo sapiens_hsa049401.14347345
46Autoimmune thyroid disease_Homo sapiens_hsa053201.12518005
47Linoleic acid metabolism_Homo sapiens_hsa005911.11149439
48Glutathione metabolism_Homo sapiens_hsa004801.09079313
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07882910
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05193081
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01131001
52RNA degradation_Homo sapiens_hsa030181.00651557
53Ether lipid metabolism_Homo sapiens_hsa005651.00246458
54Graft-versus-host disease_Homo sapiens_hsa053320.95192505
55Caffeine metabolism_Homo sapiens_hsa002320.93113108
56Taste transduction_Homo sapiens_hsa047420.88224478
57RNA polymerase_Homo sapiens_hsa030200.84820813
58DNA replication_Homo sapiens_hsa030300.82216111
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79506261
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78334398
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.74424328
62Basal transcription factors_Homo sapiens_hsa030220.71294876
63Purine metabolism_Homo sapiens_hsa002300.69994275
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.69953655
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69277251
66Renin-angiotensin system_Homo sapiens_hsa046140.64230240
67Basal cell carcinoma_Homo sapiens_hsa052170.63956281
68Morphine addiction_Homo sapiens_hsa050320.62135423
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57544444
70Circadian entrainment_Homo sapiens_hsa047130.57182592
71Metabolic pathways_Homo sapiens_hsa011000.56495115
72Vitamin digestion and absorption_Homo sapiens_hsa049770.55325306
73Histidine metabolism_Homo sapiens_hsa003400.52089505
74Protein digestion and absorption_Homo sapiens_hsa049740.50982827
75Hedgehog signaling pathway_Homo sapiens_hsa043400.48904683
76Peroxisome_Homo sapiens_hsa041460.46387476
77Insulin secretion_Homo sapiens_hsa049110.46008742
78beta-Alanine metabolism_Homo sapiens_hsa004100.46003338
79Glycerolipid metabolism_Homo sapiens_hsa005610.45340920
80p53 signaling pathway_Homo sapiens_hsa041150.42498307
81Legionellosis_Homo sapiens_hsa051340.42253509
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40989338
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.38061434
84Systemic lupus erythematosus_Homo sapiens_hsa053220.37071889
85Calcium signaling pathway_Homo sapiens_hsa040200.35613677
86Gastric acid secretion_Homo sapiens_hsa049710.35204984
87Butanoate metabolism_Homo sapiens_hsa006500.34984576
88Fat digestion and absorption_Homo sapiens_hsa049750.34821109
89Serotonergic synapse_Homo sapiens_hsa047260.33532407
90Salivary secretion_Homo sapiens_hsa049700.33064089
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31508007
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30899674
93Renin secretion_Homo sapiens_hsa049240.29001633
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.28725331
95Antigen processing and presentation_Homo sapiens_hsa046120.27243297
96GABAergic synapse_Homo sapiens_hsa047270.27215948
97Spliceosome_Homo sapiens_hsa030400.27045838
98Galactose metabolism_Homo sapiens_hsa000520.24250340
99RNA transport_Homo sapiens_hsa030130.22651510
100Pyrimidine metabolism_Homo sapiens_hsa002400.21363105

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