ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cullin deneddylation (GO:0010388)	5.20482914
2	neurotransmitter-gated ion channel clustering (GO:0072578)	5.03889184
3	protein deneddylation (GO:0000338)	4.56795765
4	ether lipid metabolic process (GO:0046485)	4.45148572
5	pseudouridine synthesis (GO:0001522)	4.03447532
6	DNA double-strand break processing (GO:0000729)	3.97158766
7	postreplication repair (GO:0006301)	3.94836678
8	DNA damage response, detection of DNA damage (GO:0042769)	3.92884969
9	retinal cone cell development (GO:0046549)	3.92669199
10	translesion synthesis (GO:0019985)	3.87446742
11	retina layer formation (GO:0010842)	3.80061973
12	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.62877446
13	platelet dense granule organization (GO:0060155)	3.58421430
14	methionine metabolic process (GO:0006555)	3.53905512
15	DNA strand elongation involved in DNA replication (GO:0006271)	3.51832502
16	protein polyglutamylation (GO:0018095)	3.51140699
17	negative regulation of DNA recombination (GO:0045910)	3.48725050
18	DNA replication initiation (GO:0006270)	3.47073611
19	nonmotile primary cilium assembly (GO:0035058)	3.46147587
20	inositol phosphate catabolic process (GO:0071545)	3.42689566
21	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.42491969
22	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.42491969
23	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.40344097
24	inositol phosphate dephosphorylation (GO:0046855)	3.40344097
25	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.39403220
26	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.39403220
27	DNA strand elongation (GO:0022616)	3.38924459
28	DNA unwinding involved in DNA replication (GO:0006268)	3.38091390
29	telomere maintenance via semi-conservative replication (GO:0032201)	3.34999820
30	adaptation of signaling pathway (GO:0023058)	3.33303756
31	inositol metabolic process (GO:0006020)	3.27170302
32	glycerol ether metabolic process (GO:0006662)	3.27061448
33	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.26468111
34	regulation of meiosis I (GO:0060631)	3.24910495
35	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.23363335
36	methionine biosynthetic process (GO:0009086)	3.22454417
37	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.22024654
38	mitochondrial RNA metabolic process (GO:0000959)	3.15533644
39	telomere maintenance via recombination (GO:0000722)	3.14231217
40	folic acid-containing compound biosynthetic process (GO:0009396)	3.11390158
41	neural tube formation (GO:0001841)	3.11266718
42	regulation of cofactor metabolic process (GO:0051193)	3.11031961
43	regulation of coenzyme metabolic process (GO:0051196)	3.11031961
44	ether metabolic process (GO:0018904)	3.09339281
45	regulation of centriole replication (GO:0046599)	3.08738742
46	amino acid salvage (GO:0043102)	3.08076359
47	L-methionine salvage (GO:0071267)	3.08076359
48	L-methionine biosynthetic process (GO:0071265)	3.08076359
49	recombinational repair (GO:0000725)	3.07643646
50	double-strand break repair via homologous recombination (GO:0000724)	3.05465351
51	mitotic recombination (GO:0006312)	3.05235487
52	water-soluble vitamin biosynthetic process (GO:0042364)	3.01275856
53	terpenoid biosynthetic process (GO:0016114)	3.00663065
54	regulation of mitotic spindle checkpoint (GO:1903504)	3.00103867
55	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.00103867
56	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.00097196
57	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.95546824
58	ubiquinone biosynthetic process (GO:0006744)	2.92924318
59	protein-cofactor linkage (GO:0018065)	2.92528914
60	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.92440683
61	positive regulation of protein homodimerization activity (GO:0090073)	2.90664815
62	protein complex biogenesis (GO:0070271)	2.86178680
63	regulation of helicase activity (GO:0051095)	2.85276749
64	retinal rod cell development (GO:0046548)	2.84934516
65	aspartate family amino acid biosynthetic process (GO:0009067)	2.84800028
66	cell wall macromolecule catabolic process (GO:0016998)	2.84346370
67	reciprocal meiotic recombination (GO:0007131)	2.80892101
68	reciprocal DNA recombination (GO:0035825)	2.80892101
69	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.80348677
70	cilium or flagellum-dependent cell motility (GO:0001539)	2.79100427
71	regulation of collateral sprouting (GO:0048670)	2.78843759
72	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.78649522
73	IMP biosynthetic process (GO:0006188)	2.76366670
74	protein sumoylation (GO:0016925)	2.74769062
75	mitochondrial respiratory chain complex assembly (GO:0033108)	2.74401704
76	branched-chain amino acid catabolic process (GO:0009083)	2.74384720
77	C-terminal protein lipidation (GO:0006501)	2.73473452
78	acrosome assembly (GO:0001675)	2.73265383
79	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.71197778
80	protein K11-linked deubiquitination (GO:0035871)	2.69795483
81	maturation of 5.8S rRNA (GO:0000460)	2.66016567
82	presynaptic membrane assembly (GO:0097105)	2.63792296
83	positive regulation of protein targeting to membrane (GO:0090314)	2.62977592
84	presynaptic membrane organization (GO:0097090)	2.62208611
85	mitotic cell cycle arrest (GO:0071850)	2.61491008
86	piRNA metabolic process (GO:0034587)	2.61274846
87	nucleobase biosynthetic process (GO:0046112)	2.60113751
88	cellular response to leptin stimulus (GO:0044320)	2.56947584
89	ubiquinone metabolic process (GO:0006743)	2.56774339
90	polyol catabolic process (GO:0046174)	2.56625326
91	sulfation (GO:0051923)	2.56209013
92	pteridine-containing compound biosynthetic process (GO:0042559)	2.55563438
93	mismatch repair (GO:0006298)	2.55540278
94	C-terminal protein amino acid modification (GO:0018410)	2.54950147
95	regulation of mitochondrial translation (GO:0070129)	2.50821673
96	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.49067631
97	NADH dehydrogenase complex assembly (GO:0010257)	2.49067631
98	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.49067631
99	tRNA processing (GO:0008033)	2.48937594
100	epithelial cilium movement (GO:0003351)	2.48789101

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.31654343
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.40438344
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.46733081
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.40273317
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.38899349
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.38838294
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.31620018
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.19061668
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.98766678
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.86982010
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.76401193
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.50855398
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.45597268
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.37810180
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33732949
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.31694628
17	FUS_26573619_Chip-Seq_HEK293_Human	2.25688853
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.17013849
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14559857
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.12002281
21	VDR_22108803_ChIP-Seq_LS180_Human	2.03201023
22	EWS_26573619_Chip-Seq_HEK293_Human	2.03155055
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.97258380
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.96380795
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.92681478
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84627926
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83371239
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.75130977
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70905585
30	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.68104266
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.66546294
32	P300_19829295_ChIP-Seq_ESCs_Human	1.64177647
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58657369
34	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.58555500
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.57775047
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56636680
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.56331975
38	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.55328268
39	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.53650766
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51895758
41	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48000267
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45651407
43	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.44321622
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42686589
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42265551
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.42265551
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.38297281
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36945605
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.36607998
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32615391
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.32329857
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.31684352
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30765160
54	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27290091
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23440670
56	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22406477
57	STAT3_23295773_ChIP-Seq_U87_Human	1.22323447
58	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.20924499
59	FOXP3_21729870_ChIP-Seq_TREG_Human	1.17707650
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17644192
61	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.17556054
62	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.17318850
63	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.16876616
64	TCF4_23295773_ChIP-Seq_U87_Human	1.14362553
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10434710
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10299267
67	DCP1A_22483619_ChIP-Seq_HELA_Human	1.10149253
68	GABP_19822575_ChIP-Seq_HepG2_Human	1.09556408
69	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.09403263
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08963152
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08216495
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06983127
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.06359693
74	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.05313791
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03994228
76	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01581076
77	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00814709
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00316050
79	AR_25329375_ChIP-Seq_VCAP_Human	0.99784322
80	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98863632
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.98819423
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98817228
83	TP53_22573176_ChIP-Seq_HFKS_Human	0.98635255
84	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98004742
85	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.97955284
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97687432
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97262169
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97095895
89	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96291662
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.96029421
91	RNF2_27304074_Chip-Seq_NSC_Mouse	0.94310968
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.93836277
93	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.93267651
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93165943
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92711908
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92523023
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.89682086
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.89493896
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.89214523
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.87481782

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.27233319
2	MP0005367_renal/urinary_system_phenotyp	3.33405631
3	MP0000516_abnormal_urinary_system	3.33405631
4	MP0010094_abnormal_chromosome_stability	3.09943521
5	MP0004270_analgesia	2.92395647
6	MP0008877_abnormal_DNA_methylation	2.86356962
7	MP0009046_muscle_twitch	2.51062740
8	MP0008058_abnormal_DNA_repair	2.50765337
9	MP0001968_abnormal_touch/_nociception	2.36304237
10	MP0003786_premature_aging	2.20489086
11	MP0002102_abnormal_ear_morphology	2.06252277
12	MP0003122_maternal_imprinting	2.05001293
13	MP0003880_abnormal_central_pattern	1.99969337
14	MP0001529_abnormal_vocalization	1.92028402
15	MP0001984_abnormal_olfaction	1.91082615
16	MP0004147_increased_porphyrin_level	1.89619245
17	MP0006276_abnormal_autonomic_nervous	1.87439906
18	MP0005646_abnormal_pituitary_gland	1.86594862
19	MP0005551_abnormal_eye_electrophysiolog	1.83653679
20	MP0004043_abnormal_pH_regulation	1.77453140
21	MP0006035_abnormal_mitochondrial_morpho	1.75900782
22	MP0002160_abnormal_reproductive_system	1.75533062
23	MP0003787_abnormal_imprinting	1.70651378
24	MP0008007_abnormal_cellular_replicative	1.67013433
25	MP0008995_early_reproductive_senescence	1.65543285
26	MP0003941_abnormal_skin_development	1.65501979
27	MP0003718_maternal_effect	1.57004805
28	MP0001299_abnormal_eye_distance/	1.49397303
29	MP0002751_abnormal_autonomic_nervous	1.48125674
30	MP0003121_genomic_imprinting	1.47784384
31	MP0002736_abnormal_nociception_after	1.45300676
32	MP0000465_gastrointestinal_hemorrhage	1.44021878
33	MP0002272_abnormal_nervous_system	1.43617873
34	MP0009745_abnormal_behavioral_response	1.43324165
35	MP0001486_abnormal_startle_reflex	1.40457133
36	MP0005389_reproductive_system_phenotype	1.36149384
37	MP0004215_abnormal_myocardial_fiber	1.34543158
38	MP0001919_abnormal_reproductive_system	1.30699609
39	MP0004142_abnormal_muscle_tone	1.29987750
40	MP0002064_seizures	1.29972344
41	MP0008872_abnormal_physiological_respon	1.23824516
42	MP0000569_abnormal_digit_pigmentation	1.22313882
43	MP0003119_abnormal_digestive_system	1.20803695
44	MP0010307_abnormal_tumor_latency	1.19195171
45	MP0003635_abnormal_synaptic_transmissio	1.17106858
46	MP0002734_abnormal_mechanical_nocicepti	1.14068241
47	MP0000015_abnormal_ear_pigmentation	1.11715372
48	MP0005075_abnormal_melanosome_morpholog	1.08940204
49	MP0003111_abnormal_nucleus_morphology	1.08787254
50	MP0002572_abnormal_emotion/affect_behav	1.08354613
51	MP0006036_abnormal_mitochondrial_physio	1.07068162
52	MP0002735_abnormal_chemical_nociception	1.06593755
53	MP0001293_anophthalmia	1.04649781
54	MP0003937_abnormal_limbs/digits/tail_de	1.03726070
55	MP0006072_abnormal_retinal_apoptosis	1.03669711
56	MP0002638_abnormal_pupillary_reflex	1.02418480
57	MP0003137_abnormal_impulse_conducting	1.02401799
58	MP0002090_abnormal_vision	1.02308607
59	MP0009697_abnormal_copulation	1.02213841
60	MP0008789_abnormal_olfactory_epithelium	1.01507501
61	MP0000566_synostosis	0.99964423
62	MP0005253_abnormal_eye_physiology	0.99852090
63	MP0000631_abnormal_neuroendocrine_gland	0.99847571
64	MP0002063_abnormal_learning/memory/cond	0.98194359
65	MP0003077_abnormal_cell_cycle	0.97335814
66	MP0000778_abnormal_nervous_system	0.96970184
67	MP0002938_white_spotting	0.95023591
68	MP0006054_spinal_hemorrhage	0.90922581
69	MP0000647_abnormal_sebaceous_gland	0.90074530
70	MP0002067_abnormal_sensory_capabilities	0.89976014
71	MP0001177_atelectasis	0.88995470
72	MP0005187_abnormal_penis_morphology	0.88891674
73	MP0002928_abnormal_bile_duct	0.88450997
74	MP0001929_abnormal_gametogenesis	0.87261442
75	MP0006292_abnormal_olfactory_placode	0.85968677
76	MP0002557_abnormal_social/conspecific_i	0.85145008
77	MP0001324_abnormal_eye_pigmentation	0.84860647
78	MP0002184_abnormal_innervation	0.81435276
79	MP0002234_abnormal_pharynx_morphology	0.80512081
80	MP0005645_abnormal_hypothalamus_physiol	0.79998042
81	MP0004859_abnormal_synaptic_plasticity	0.79434662
82	MP0008932_abnormal_embryonic_tissue	0.78914627
83	MP0003646_muscle_fatigue	0.77629943
84	MP0000653_abnormal_sex_gland	0.77130189
85	MP0002210_abnormal_sex_determination	0.76807364
86	MP0005174_abnormal_tail_pigmentation	0.75967992
87	MP0005220_abnormal_exocrine_pancreas	0.73986944
88	MP0003698_abnormal_male_reproductive	0.73871754
89	MP0003656_abnormal_erythrocyte_physiolo	0.73430573
90	MP0000358_abnormal_cell_content/	0.73105111
91	MP0005266_abnormal_metabolism	0.71897410
92	MP0005195_abnormal_posterior_eye	0.71461391
93	MP0001145_abnormal_male_reproductive	0.70750377
94	MP0001970_abnormal_pain_threshold	0.69935948
95	MP0004133_heterotaxia	0.69819002
96	MP0000537_abnormal_urethra_morphology	0.69717292
97	MP0002177_abnormal_outer_ear	0.68446507
98	MP0005499_abnormal_olfactory_system	0.67960577
99	MP0005394_taste/olfaction_phenotype	0.67960577
100	MP0002095_abnormal_skin_pigmentation	0.66922602

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.90750770
2	Abnormality of alanine metabolism (HP:0010916)	3.90750770
3	Hyperalaninemia (HP:0003348)	3.90750770
4	Pancreatic fibrosis (HP:0100732)	3.88099652
5	Methylmalonic acidemia (HP:0002912)	3.85781326
6	Pancreatic cysts (HP:0001737)	3.84369501
7	Focal motor seizures (HP:0011153)	3.82172466
8	Abnormal hair whorl (HP:0010721)	3.07272821
9	Meckel diverticulum (HP:0002245)	3.03351132
10	Febrile seizures (HP:0002373)	2.96817233
11	True hermaphroditism (HP:0010459)	2.93730418
12	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.86114623
13	Abnormality of chromosome stability (HP:0003220)	2.84280709
14	Abnormality of the ileum (HP:0001549)	2.83254099
15	Abnormality of midbrain morphology (HP:0002418)	2.82766738
16	Molar tooth sign on MRI (HP:0002419)	2.82766738
17	Absence seizures (HP:0002121)	2.77422187
18	Genital tract atresia (HP:0001827)	2.75581304
19	Dialeptic seizures (HP:0011146)	2.71334575
20	Broad-based gait (HP:0002136)	2.69086470
21	Nephrogenic diabetes insipidus (HP:0009806)	2.67837959
22	Congenital primary aphakia (HP:0007707)	2.62246091
23	Medial flaring of the eyebrow (HP:0010747)	2.61804460
24	Gait imbalance (HP:0002141)	2.61361338
25	Abnormality of the preputium (HP:0100587)	2.57388874
26	Hyperglycinemia (HP:0002154)	2.57295559
27	Tubulointerstitial nephritis (HP:0001970)	2.53672553
28	Septate vagina (HP:0001153)	2.52838972
29	Abnormality of macular pigmentation (HP:0008002)	2.52570520
30	Central scotoma (HP:0000603)	2.51975775
31	Rectovaginal fistula (HP:0000143)	2.50761964
32	Rectal fistula (HP:0100590)	2.50761964
33	Gaze-evoked nystagmus (HP:0000640)	2.50100135
34	Methylmalonic aciduria (HP:0012120)	2.48083310
35	Albinism (HP:0001022)	2.48061035
36	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.46536769
37	Nephronophthisis (HP:0000090)	2.45506093
38	Clubbing of toes (HP:0100760)	2.44220681
39	Intestinal atresia (HP:0011100)	2.41346825
40	Polyphagia (HP:0002591)	2.37769415
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.37304821
42	Vaginal atresia (HP:0000148)	2.36404077
43	Atonic seizures (HP:0010819)	2.36395165
44	Pendular nystagmus (HP:0012043)	2.35837481
45	Short tibia (HP:0005736)	2.32726498
46	Delayed CNS myelination (HP:0002188)	2.32234239
47	Ependymoma (HP:0002888)	2.29433288
48	Abnormality of vitamin B metabolism (HP:0004340)	2.26349486
49	Scotoma (HP:0000575)	2.21765997
50	Abnormality of the duodenum (HP:0002246)	2.21633747
51	Small intestinal stenosis (HP:0012848)	2.21159549
52	Duodenal stenosis (HP:0100867)	2.21159549
53	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.19318011
54	Vaginal fistula (HP:0004320)	2.16332466
55	Progressive inability to walk (HP:0002505)	2.15543460
56	Hemiparesis (HP:0001269)	2.11242304
57	Abolished electroretinogram (ERG) (HP:0000550)	2.10390171
58	Abnormality of the renal collecting system (HP:0004742)	2.09173977
59	Supernumerary spleens (HP:0009799)	2.08355766
60	Abnormality of the renal medulla (HP:0100957)	2.07923698
61	Astigmatism (HP:0000483)	2.07468089
62	Abnormality of the renal cortex (HP:0011035)	2.07352995
63	Focal seizures (HP:0007359)	2.06697999
64	Hyperventilation (HP:0002883)	2.05747127
65	Lipid accumulation in hepatocytes (HP:0006561)	2.04047578
66	Postaxial foot polydactyly (HP:0001830)	2.03550875
67	Glioma (HP:0009733)	2.02476247
68	Dysdiadochokinesis (HP:0002075)	2.02301003
69	Abnormality of the astrocytes (HP:0100707)	2.02016746
70	Astrocytoma (HP:0009592)	2.02016746
71	Attenuation of retinal blood vessels (HP:0007843)	2.01791627
72	Abnormality of serum amino acid levels (HP:0003112)	1.99697443
73	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.97434998
74	Acute necrotizing encephalopathy (HP:0006965)	1.97370602
75	Cupped ear (HP:0000378)	1.96920784
76	Bifid tongue (HP:0010297)	1.96507110
77	Posterior subcapsular cataract (HP:0007787)	1.95969959
78	Progressive cerebellar ataxia (HP:0002073)	1.95760749
79	Progressive macrocephaly (HP:0004481)	1.93448434
80	Epileptic encephalopathy (HP:0200134)	1.92820736
81	Intestinal fistula (HP:0100819)	1.92520594
82	Abnormal mitochondria in muscle tissue (HP:0008316)	1.92371051
83	Sloping forehead (HP:0000340)	1.91712409
84	Gastrointestinal atresia (HP:0002589)	1.90942416
85	Horizontal nystagmus (HP:0000666)	1.88719419
86	Poor coordination (HP:0002370)	1.88474681
87	Triphalangeal thumb (HP:0001199)	1.87347954
88	Chromsome breakage (HP:0040012)	1.86693436
89	Postaxial hand polydactyly (HP:0001162)	1.86296924
90	Anencephaly (HP:0002323)	1.85157359
91	Impaired vibration sensation in the lower limbs (HP:0002166)	1.84993114
92	Abnormality of glycolysis (HP:0004366)	1.82905753
93	Renal cortical cysts (HP:0000803)	1.81236829
94	Aplastic anemia (HP:0001915)	1.80454706
95	Multiple enchondromatosis (HP:0005701)	1.80043187
96	Duplicated collecting system (HP:0000081)	1.79809609
97	Spastic tetraparesis (HP:0001285)	1.79230989
98	Postnatal microcephaly (HP:0005484)	1.78466560
99	Mitochondrial inheritance (HP:0001427)	1.78223904
100	Abnormality of the carotid arteries (HP:0005344)	1.77393456

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	5.00070783
2	NUAK1	4.48757785
3	MAP4K2	4.00910097
4	BCKDK	3.97175604
5	FRK	3.76995084
6	PIM2	3.30496861
7	BMPR1B	2.74550582
8	TAF1	2.74003409
9	MKNK1	2.66449648
10	MKNK2	2.46021070
11	SRPK1	2.27036199
12	CCNB1	2.09197794
13	BCR	1.81053589
14	MARK1	1.74478231
15	CDK19	1.65515416
16	ZAK	1.60147429
17	TRIM28	1.58189036
18	CASK	1.50701155
19	ERBB3	1.47758638
20	EIF2AK1	1.46993826
21	GRK5	1.44865087
22	CDC7	1.38208253
23	PLK2	1.38122516
24	ADRBK2	1.31293211
25	ACVR1B	1.25040337
26	PLK3	1.16792149
27	ATR	1.16486077
28	PNCK	1.14331648
29	BUB1	1.13665020
30	STK16	1.12482196
31	SIK2	1.06688664
32	TSSK6	1.02160771
33	MAP3K4	1.01559082
34	GRK1	0.97916531
35	LIMK1	0.96123896
36	VRK2	0.95377233
37	MAP3K12	0.90925323
38	CSNK1G3	0.86509531
39	MAPK13	0.84836883
40	FGFR2	0.82417890
41	TGFBR1	0.81594619
42	MAP2K7	0.80791839
43	CSNK1A1L	0.80093931
44	PLK1	0.79493208
45	GRK6	0.79277029
46	CSNK1G2	0.79153004
47	OXSR1	0.76036555
48	DYRK1A	0.75343172
49	STK39	0.73739715
50	PIM1	0.73599887
51	PRKCE	0.72952019
52	CSNK1G1	0.72205301
53	RPS6KA5	0.72032006
54	PRKCG	0.70490150
55	VRK1	0.68945293
56	MAPKAPK5	0.68660379
57	OBSCN	0.67422561
58	ATM	0.65819612
59	NME1	0.61873146
60	MAP3K5	0.59864439
61	ILK	0.59441955
62	STK24	0.57865537
63	PRKCZ	0.56191771
64	CSNK1D	0.53295057
65	TNIK	0.52717541
66	NEK1	0.52529075
67	INSRR	0.52367157
68	MAP3K11	0.51531444
69	CAMK2A	0.49992884
70	PRKAA2	0.48217346
71	DAPK1	0.47355693
72	CDK6	0.46444228
73	TTK	0.45978258
74	CHEK2	0.45893718
75	PTK2B	0.45490623
76	CSNK1A1	0.44693032
77	FER	0.44528554
78	CDK3	0.44293081
79	BRSK2	0.41212608
80	AURKB	0.40632069
81	TESK1	0.39966761
82	PHKG2	0.39924556
83	PHKG1	0.39924556
84	ADRBK1	0.36012183
85	PASK	0.35182136
86	CAMK1G	0.34210130
87	PRKDC	0.34001666
88	CSNK1E	0.33667697
89	DAPK2	0.33659676
90	RAF1	0.32793493
91	EIF2AK3	0.32775355
92	YES1	0.31795732
93	DAPK3	0.29917190
94	NTRK2	0.27487678
95	CSNK2A2	0.27440225
96	FLT3	0.24338322
97	CSNK2A1	0.24261253
98	DYRK2	0.23980433
99	PRKG1	0.23842710
100	CDK14	0.23412813

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.65771472
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.17814213
3	Mismatch repair_Homo sapiens_hsa03430	2.92244398
4	Homologous recombination_Homo sapiens_hsa03440	2.83801375
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.72157350
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.71519941
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.43472101
8	Propanoate metabolism_Homo sapiens_hsa00640	2.33923957
9	Folate biosynthesis_Homo sapiens_hsa00790	2.09860679
10	Protein export_Homo sapiens_hsa03060	2.01178282
11	Proteasome_Homo sapiens_hsa03050	1.87229736
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.85862516
13	Phototransduction_Homo sapiens_hsa04744	1.84791583
14	Fatty acid elongation_Homo sapiens_hsa00062	1.76066210
15	Nicotine addiction_Homo sapiens_hsa05033	1.61568607
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.60835799
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.58123168
18	Peroxisome_Homo sapiens_hsa04146	1.53148908
19	RNA transport_Homo sapiens_hsa03013	1.51342774
20	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.50646754
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.50356981
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.47791092
23	One carbon pool by folate_Homo sapiens_hsa00670	1.43200196
24	Butanoate metabolism_Homo sapiens_hsa00650	1.42515286
25	Parkinsons disease_Homo sapiens_hsa05012	1.42048514
26	RNA polymerase_Homo sapiens_hsa03020	1.41679814
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41474841
28	GABAergic synapse_Homo sapiens_hsa04727	1.41077598
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.40546906
30	Spliceosome_Homo sapiens_hsa03040	1.38177207
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.32135495
32	Steroid biosynthesis_Homo sapiens_hsa00100	1.31641847
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31031322
34	Basal transcription factors_Homo sapiens_hsa03022	1.29851213
35	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.26688287
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26106062
37	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.25502334
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.24630100
39	Base excision repair_Homo sapiens_hsa03410	1.21429275
40	Fatty acid metabolism_Homo sapiens_hsa01212	1.19523617
41	Regulation of autophagy_Homo sapiens_hsa04140	1.19085295
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.17359149
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.14837400
44	Linoleic acid metabolism_Homo sapiens_hsa00591	1.14597838
45	Long-term depression_Homo sapiens_hsa04730	1.10483858
46	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.09211945
47	RNA degradation_Homo sapiens_hsa03018	1.08165767
48	Pyruvate metabolism_Homo sapiens_hsa00620	1.07242457
49	Taste transduction_Homo sapiens_hsa04742	1.06114284
50	Huntingtons disease_Homo sapiens_hsa05016	1.05152390
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.04331577
52	Pentose phosphate pathway_Homo sapiens_hsa00030	1.03712215
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00241444
54	ABC transporters_Homo sapiens_hsa02010	0.95094821
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94637100
56	Morphine addiction_Homo sapiens_hsa05032	0.93707868
57	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.90830129
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.90177930
59	Alzheimers disease_Homo sapiens_hsa05010	0.89799311
60	Circadian entrainment_Homo sapiens_hsa04713	0.89128266
61	Purine metabolism_Homo sapiens_hsa00230	0.87469156
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86723821
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86632963
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85927886
65	Glutathione metabolism_Homo sapiens_hsa00480	0.81515843
66	Cell cycle_Homo sapiens_hsa04110	0.81176011
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79324893
68	Carbon metabolism_Homo sapiens_hsa01200	0.78693652
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.77734197
70	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.76122104
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72688712
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.72530176
73	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.68947588
74	Metabolic pathways_Homo sapiens_hsa01100	0.67296284
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67049227
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65552742
77	Olfactory transduction_Homo sapiens_hsa04740	0.64673577
78	Serotonergic synapse_Homo sapiens_hsa04726	0.60473160
79	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.59491791
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.57198148
81	Oocyte meiosis_Homo sapiens_hsa04114	0.56465950
82	Retinol metabolism_Homo sapiens_hsa00830	0.53938106
83	Insulin secretion_Homo sapiens_hsa04911	0.52988491
84	Salivary secretion_Homo sapiens_hsa04970	0.52017728
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50329484
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49543851
87	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.48601263
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.46649901
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46624196
90	Caffeine metabolism_Homo sapiens_hsa00232	0.44177594
91	Sulfur relay system_Homo sapiens_hsa04122	0.39759661
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.39134087
93	Fatty acid degradation_Homo sapiens_hsa00071	0.36972524
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.34935641
95	p53 signaling pathway_Homo sapiens_hsa04115	0.33998657
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.32909661
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.32550051
98	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.32438786
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31689285
100	mRNA surveillance pathway_Homo sapiens_hsa03015	0.31428927

MTND2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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