MTND2P26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1potassium ion import (GO:0010107)9.35553513
2positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)7.70515362
3lymph vessel development (GO:0001945)7.12766023
4outer ear morphogenesis (GO:0042473)5.95940149
5positive regulation of protein kinase C signaling (GO:0090037)5.80438620
6synaptic transmission, dopaminergic (GO:0001963)5.79948322
7cochlea development (GO:0090102)5.54322885
8negative regulation of sodium ion transport (GO:0010766)5.42570039
9regulation of transforming growth factor beta2 production (GO:0032909)5.38484803
10cGMP biosynthetic process (GO:0006182)4.84292155
11positive regulation of action potential (GO:0045760)4.45586546
12cGMP metabolic process (GO:0046068)4.45464293
13regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.39480421
14regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.39480421
15cellular response to ethanol (GO:0071361)4.28195894
16behavioral response to cocaine (GO:0048148)4.13503816
17negative regulation of oligodendrocyte differentiation (GO:0048715)4.12945739
18multicellular organismal movement (GO:0050879)4.05529767
19musculoskeletal movement (GO:0050881)4.05529767
20artery development (GO:0060840)4.04608254
21positive regulation of amino acid transport (GO:0051957)4.02005437
22facial nerve structural organization (GO:0021612)4.01478998
23plasma membrane repair (GO:0001778)3.90710661
24positive regulation of uterine smooth muscle contraction (GO:0070474)3.90242835
25vasodilation (GO:0042311)3.87672918
26response to exogenous dsRNA (GO:0043330)3.87014344
27negative regulation of macroautophagy (GO:0016242)3.82036499
28ventricular septum morphogenesis (GO:0060412)3.70629272
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.69286869
30retinal cone cell development (GO:0046549)3.52065741
31polyamine biosynthetic process (GO:0006596)3.50972312
32gamma-aminobutyric acid transport (GO:0015812)3.50707449
33cAMP catabolic process (GO:0006198)3.47442450
34negative regulation of glial cell differentiation (GO:0045686)3.43721363
35spinal cord development (GO:0021510)3.36502506
36inositol phosphate-mediated signaling (GO:0048016)3.35377844
37regulation of neurotransmitter uptake (GO:0051580)3.33691202
38prepulse inhibition (GO:0060134)3.32586109
39head development (GO:0060322)3.27145893
40nephron tubule morphogenesis (GO:0072078)3.26974291
41nephron epithelium morphogenesis (GO:0072088)3.26974291
42response to dsRNA (GO:0043331)3.23799011
43adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.23125763
44positive regulation of cGMP biosynthetic process (GO:0030828)3.20272975
45positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.18736458
46positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.11473320
47reflex (GO:0060004)3.10836330
48regulation of proton transport (GO:0010155)3.10648621
49cyclic nucleotide catabolic process (GO:0009214)3.08535275
50negative regulation of cell aging (GO:0090344)3.06971980
51positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.06389966
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01861795
53cranial nerve structural organization (GO:0021604)3.01783582
54cellular biogenic amine biosynthetic process (GO:0042401)3.00721272
55positive regulation of vascular permeability (GO:0043117)3.00634588
56nodal signaling pathway (GO:0038092)3.00253665
57regulation of cGMP biosynthetic process (GO:0030826)2.98623500
58regulation of protein kinase C signaling (GO:0090036)2.97140517
59positive regulation of transforming growth factor beta production (GO:0071636)2.96880889
60amine catabolic process (GO:0009310)2.96265729
61cellular biogenic amine catabolic process (GO:0042402)2.96265729
62cochlea morphogenesis (GO:0090103)2.95413052
63positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.94771153
64cell morphogenesis involved in neuron differentiation (GO:0048667)2.94515039
65arachidonic acid secretion (GO:0050482)2.94017755
66icosanoid secretion (GO:0032309)2.94017755
67platelet dense granule organization (GO:0060155)2.93955652
68relaxation of smooth muscle (GO:0044557)2.93772636
69positive regulation of ERBB signaling pathway (GO:1901186)2.91688214
70embryonic camera-type eye morphogenesis (GO:0048596)2.91260775
71negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89682132
72renal tubule morphogenesis (GO:0061333)2.89595858
73positive regulation of renal sodium excretion (GO:0035815)2.88666174
74positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.87679740
75regulation of autophagic vacuole assembly (GO:2000785)2.86158917
76regulation of uterine smooth muscle contraction (GO:0070472)2.85169927
77lung-associated mesenchyme development (GO:0060484)2.83469062
78sodium ion export (GO:0071436)2.83444540
79regulation of ARF protein signal transduction (GO:0032012)2.82897084
80diacylglycerol metabolic process (GO:0046339)2.82744965
81response to isoquinoline alkaloid (GO:0014072)2.82458846
82response to morphine (GO:0043278)2.81570133
83base-excision repair, AP site formation (GO:0006285)2.80874247
84amine biosynthetic process (GO:0009309)2.78397529
85positive regulation of cGMP metabolic process (GO:0030825)2.74533414
86histone H3-K36 demethylation (GO:0070544)2.71364119
87negative regulation of astrocyte differentiation (GO:0048712)2.69401134
88response to pH (GO:0009268)2.68123223
89cellular response to estradiol stimulus (GO:0071392)2.67926190
90negative regulation of Rho protein signal transduction (GO:0035024)2.67341392
91artery morphogenesis (GO:0048844)2.66806598
92positive regulation of neurotransmitter secretion (GO:0001956)2.66169036
93positive regulation of multicellular organism growth (GO:0040018)2.62836307
94regulation of action potential (GO:0098900)2.62618318
95autophagic vacuole fusion (GO:0000046)2.60583773
96cGMP-mediated signaling (GO:0019934)2.58862091
97mesenchymal cell development (GO:0014031)2.58554245
98mesenchyme morphogenesis (GO:0072132)2.58247610
99regulation of cGMP metabolic process (GO:0030823)2.57629435
100outflow tract morphogenesis (GO:0003151)2.57321941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.03247342
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77327525
3EZH2_22144423_ChIP-Seq_EOC_Human3.65223088
4GATA1_22025678_ChIP-Seq_K562_Human3.63495819
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67416113
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.57989408
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.57989408
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.57989408
9VDR_22108803_ChIP-Seq_LS180_Human2.53894375
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46168862
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.39795900
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34629069
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.29313552
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19463903
15CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18347329
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.17729432
17GBX2_23144817_ChIP-Seq_PC3_Human2.09089249
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93918767
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93681744
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.90928931
21IGF1R_20145208_ChIP-Seq_DFB_Human1.90180030
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86969623
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81069479
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76529276
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.75440774
26RNF2_27304074_Chip-Seq_NSC_Mouse1.72532615
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68671803
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65796162
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64217558
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.61419087
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59183466
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.58318888
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55871160
34P300_19829295_ChIP-Seq_ESCs_Human1.55544028
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51086154
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47770934
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46883996
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.46197795
39AR_25329375_ChIP-Seq_VCAP_Human1.44981074
40STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35763254
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35271312
42CBP_20019798_ChIP-Seq_JUKART_Human1.34757007
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34757007
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.29816625
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29792132
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29643565
47FUS_26573619_Chip-Seq_HEK293_Human1.27991870
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26609439
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26551567
50TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26021302
51TCF4_23295773_ChIP-Seq_U87_Human1.25491571
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25053206
53NFYA_21822215_ChIP-Seq_K562_Human1.24301217
54ZNF274_21170338_ChIP-Seq_K562_Hela1.23502998
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22788227
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22138743
57SMAD4_21799915_ChIP-Seq_A2780_Human1.21726325
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21269029
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20858500
60BCAT_22108803_ChIP-Seq_LS180_Human1.20410768
61TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19403208
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18320478
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17031411
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16282703
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14801531
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14207770
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14003841
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13578918
69CJUN_26792858_Chip-Seq_BT549_Human1.12701757
70RXR_22108803_ChIP-Seq_LS180_Human1.11699075
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10843972
72RUNX2_22187159_ChIP-Seq_PCA_Human1.09616165
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08989957
74STAT3_23295773_ChIP-Seq_U87_Human1.08607445
75AR_21572438_ChIP-Seq_LNCaP_Human1.06225377
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.05893478
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05178543
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05104153
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.05003022
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03910436
81ER_23166858_ChIP-Seq_MCF-7_Human1.03089253
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02770092
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.01014941
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00561567
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.00359993
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00056619
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99850978
88SOX2_19829295_ChIP-Seq_ESCs_Human0.99534045
89NANOG_19829295_ChIP-Seq_ESCs_Human0.99534045
90CBP_21632823_ChIP-Seq_H3396_Human0.98901899
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98549617
92TBL1_22424771_ChIP-Seq_293T_Human0.98376263
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97797025
94GF1_26923725_Chip-Seq_HPCs_Mouse0.96806125
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.96448852
96TAF15_26573619_Chip-Seq_HEK293_Human0.95701668
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.95044254
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.94302375
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93263720
100WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92700593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia8.97240427
2MP0001879_abnormal_lymphatic_vessel3.52255305
3MP0005423_abnormal_somatic_nervous3.39837889
4MP0002822_catalepsy3.02704102
5MP0001986_abnormal_taste_sensitivity2.99782201
6MP0002734_abnormal_mechanical_nocicepti2.91859610
7MP0005451_abnormal_body_composition2.86810942
8MP0002166_altered_tumor_susceptibility2.80013443
9MP0006072_abnormal_retinal_apoptosis2.33625641
10MP0004215_abnormal_myocardial_fiber2.28626971
11MP0000230_abnormal_systemic_arterial2.18443811
12MP0000569_abnormal_digit_pigmentation2.08014672
13MP0002006_tumorigenesis2.06768893
14MP0005645_abnormal_hypothalamus_physiol2.04287450
15MP0009384_cardiac_valve_regurgitation1.99246846
16MP0003119_abnormal_digestive_system1.92002915
17MP0004085_abnormal_heartbeat1.68307528
18MP0008058_abnormal_DNA_repair1.63801310
19MP0008995_early_reproductive_senescence1.61344754
20MP0004145_abnormal_muscle_electrophysio1.60385806
21MP0002638_abnormal_pupillary_reflex1.60119273
22MP0008872_abnormal_physiological_respon1.59143951
23MP0000516_abnormal_urinary_system1.56395191
24MP0005367_renal/urinary_system_phenotyp1.56395191
25MP0001970_abnormal_pain_threshold1.51317199
26MP0004272_abnormal_basement_membrane1.44394953
27MP0004270_analgesia1.43570976
28MP0001486_abnormal_startle_reflex1.41694559
29MP0005646_abnormal_pituitary_gland1.40906726
30MP0009046_muscle_twitch1.40291738
31MP0005253_abnormal_eye_physiology1.39204032
32MP0005620_abnormal_muscle_contractility1.37776551
33MP0005551_abnormal_eye_electrophysiolog1.37399050
34MP0001664_abnormal_digestion1.35954675
35MP0003137_abnormal_impulse_conducting1.35735138
36MP0000678_abnormal_parathyroid_gland1.34452130
37MP0010386_abnormal_urinary_bladder1.34372035
38MP0002160_abnormal_reproductive_system1.31090928
39MP0005448_abnormal_energy_balance1.30519474
40MP0002272_abnormal_nervous_system1.26930217
41MP0002735_abnormal_chemical_nociception1.25128621
42MP0000750_abnormal_muscle_regeneration1.23998694
43MP0001905_abnormal_dopamine_level1.22938390
44MP0000049_abnormal_middle_ear1.20198662
45MP0003195_calcinosis1.19325078
46MP0005595_abnormal_vascular_smooth1.17845388
47MP0004885_abnormal_endolymph1.16820448
48MP0000470_abnormal_stomach_morphology1.16163079
49MP0002928_abnormal_bile_duct1.10972815
50MP0005164_abnormal_response_to1.09839295
51MP0001485_abnormal_pinna_reflex1.08297916
52MP0009697_abnormal_copulation1.08116578
53MP0003938_abnormal_ear_development1.06874146
54MP0005310_abnormal_salivary_gland1.05309449
55MP0009745_abnormal_behavioral_response1.03241463
56MP0001440_abnormal_grooming_behavior0.96647377
57MP0003941_abnormal_skin_development0.96457931
58MP0002909_abnormal_adrenal_gland0.96111204
59MP0000538_abnormal_urinary_bladder0.95313120
60MP0001968_abnormal_touch/_nociception0.89213492
61MP0003045_fibrosis0.88158101
62MP0003943_abnormal_hepatobiliary_system0.87175311
63MP0002693_abnormal_pancreas_physiology0.86408684
64MP0002733_abnormal_thermal_nociception0.85736051
65MP0003136_yellow_coat_color0.84610734
66MP0003935_abnormal_craniofacial_develop0.84608172
67MP0005195_abnormal_posterior_eye0.84420699
68MP0000026_abnormal_inner_ear0.83280566
69MP0002069_abnormal_eating/drinking_beha0.81783033
70MP0004742_abnormal_vestibular_system0.81755512
71MP0002736_abnormal_nociception_after0.80972112
72MP0005220_abnormal_exocrine_pancreas0.79644221
73MP0000631_abnormal_neuroendocrine_gland0.77604402
74MP0005503_abnormal_tendon_morphology0.76320357
75MP0005386_behavior/neurological_phenoty0.75257807
76MP0004924_abnormal_behavior0.75257807
77MP0000762_abnormal_tongue_morphology0.75220077
78MP0002067_abnormal_sensory_capabilities0.74415372
79MP0003755_abnormal_palate_morphology0.73387508
80MP0005187_abnormal_penis_morphology0.73242800
81MP0002752_abnormal_somatic_nervous0.73125586
82MP0002108_abnormal_muscle_morphology0.72184421
83MP0001756_abnormal_urination0.70302840
84MP0000343_altered_response_to0.69628238
85MP0005452_abnormal_adipose_tissue0.68221279
86MP0004142_abnormal_muscle_tone0.66427213
87MP0004484_altered_response_of0.66391022
88MP0001984_abnormal_olfaction0.65874043
89MP0002168_other_aberrant_phenotype0.65854509
90MP0004036_abnormal_muscle_relaxation0.62799498
91MP0005167_abnormal_blood-brain_barrier0.62754955
92MP0005395_other_phenotype0.62129987
93MP0005389_reproductive_system_phenotype0.60890781
94MP0008875_abnormal_xenobiotic_pharmacok0.60841837
95MP0003890_abnormal_embryonic-extraembry0.60116271
96MP0002229_neurodegeneration0.58717062
97MP0005391_vision/eye_phenotype0.56677058
98MP0003718_maternal_effect0.56570020
99MP0001324_abnormal_eye_pigmentation0.55729801
100MP0005376_homeostasis/metabolism_phenot0.55597838

Predicted human phenotypes

RankGene SetZ-score
1Short hallux (HP:0010109)6.77355708
2Aplasia/Hypoplasia of the hallux (HP:0008362)6.31104283
3Prominent supraorbital ridges (HP:0000336)5.39284903
4Scotoma (HP:0000575)4.38668816
5Preaxial foot polydactyly (HP:0001841)4.17854446
6Broad distal phalanx of finger (HP:0009836)4.13493865
711 pairs of ribs (HP:0000878)4.05450583
8Short nail (HP:0001799)4.04619072
9Broad metatarsal (HP:0001783)3.95639304
10Type II lissencephaly (HP:0007260)3.95353996
11Posterior subcapsular cataract (HP:0007787)3.92334562
12Duplicated collecting system (HP:0000081)3.90672113
13Hypoplastic ischia (HP:0003175)3.82644276
14Congenital, generalized hypertrichosis (HP:0004540)3.81561430
15Abnormality of the renal collecting system (HP:0004742)3.64986765
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63777851
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.61361837
18Depressed nasal tip (HP:0000437)3.54121110
19Abnormality of the ischium (HP:0003174)3.50932423
20Large for gestational age (HP:0001520)3.38051781
21Bicuspid aortic valve (HP:0001647)3.36308978
22Chromsome breakage (HP:0040012)3.34869621
23Pheochromocytoma (HP:0002666)3.30497016
24Abnormality of the phalanges of the 2nd finger (HP:0009541)3.26161811
25Furrowed tongue (HP:0000221)3.25145943
26Spinal cord compression (HP:0002176)3.21516556
27Absent/shortened dynein arms (HP:0200106)3.20444216
28Dynein arm defect of respiratory motile cilia (HP:0012255)3.20444216
29Bony spicule pigmentary retinopathy (HP:0007737)3.20057286
30Abnormality of midbrain morphology (HP:0002418)3.15685358
31Molar tooth sign on MRI (HP:0002419)3.15685358
32Mesangial abnormality (HP:0001966)3.08380027
33Hemiparesis (HP:0001269)3.00730412
34Reticulocytopenia (HP:0001896)2.92561555
35Ovoid vertebral bodies (HP:0003300)2.91719452
36Neuroendocrine neoplasm (HP:0100634)2.84164234
37Abnormal rod and cone electroretinograms (HP:0008323)2.81739886
38Flared iliac wings (HP:0002869)2.81141750
39Hyperventilation (HP:0002883)2.75848314
40Absent toe (HP:0010760)2.70137146
41Central scotoma (HP:0000603)2.65540411
42Constricted visual fields (HP:0001133)2.61739693
43True hermaphroditism (HP:0010459)2.60297043
44Pancreatic cysts (HP:0001737)2.59515684
45Low posterior hairline (HP:0002162)2.58600812
46Accelerated skeletal maturation (HP:0005616)2.58085487
47Abnormality of lateral ventricle (HP:0030047)2.52600365
48Cupped ribs (HP:0000887)2.51845060
49Pancreatic fibrosis (HP:0100732)2.51576320
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.49136971
51Retinal dysplasia (HP:0007973)2.45859564
52Congenital stationary night blindness (HP:0007642)2.44232244
53Cardiomegaly (HP:0001640)2.43960133
54Low anterior hairline (HP:0000294)2.43261583
55Attenuation of retinal blood vessels (HP:0007843)2.40355375
56Radial bowing (HP:0002986)2.39108190
57Focal segmental glomerulosclerosis (HP:0000097)2.38779722
58Delayed CNS myelination (HP:0002188)2.33385597
59Oligodactyly (hands) (HP:0001180)2.30984940
60Coxa valga (HP:0002673)2.24062098
61Abdominal situs inversus (HP:0003363)2.23090518
62Abnormality of abdominal situs (HP:0011620)2.23090518
63Abnormality of DNA repair (HP:0003254)2.23046266
64Ulnar claw (HP:0001178)2.21122170
65Nephronophthisis (HP:0000090)2.19901987
66Slender long bone (HP:0003100)2.18902805
67Clumsiness (HP:0002312)2.18456558
68Neurodegeneration (HP:0002180)2.18106766
69Sparse scalp hair (HP:0002209)2.15069393
70Hamartoma of the eye (HP:0010568)2.13199562
71Abnormality of binocular vision (HP:0011514)2.12232879
72Diplopia (HP:0000651)2.12232879
73Global brain atrophy (HP:0002283)2.10687858
74Irregular vertebral endplates (HP:0003301)2.09914919
75Thick eyebrow (HP:0000574)2.09264679
76Long nose (HP:0003189)2.08116183
77Abnormality of the vertebral endplates (HP:0005106)2.04452219
78Genetic anticipation (HP:0003743)2.02765647
79Abolished electroretinogram (ERG) (HP:0000550)2.02498576
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.99359893
81Abnormality of the vocal cords (HP:0008777)1.98523348
82Diastasis recti (HP:0001540)1.95993528
83Ureteral duplication (HP:0000073)1.95267734
84Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95239434
85Cerebellar dysplasia (HP:0007033)1.88892859
86Progressive cerebellar ataxia (HP:0002073)1.87324764
87Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.84076096
88Non-midline cleft lip (HP:0100335)1.81404372
89Abnormality of the pubic bones (HP:0003172)1.78636548
90Abnormal ciliary motility (HP:0012262)1.78038799
91Missing ribs (HP:0000921)1.75936800
92Subcapsular cataract (HP:0000523)1.74956639
93Rhabdomyosarcoma (HP:0002859)1.73986457
94Abnormality of the 2nd finger (HP:0004100)1.73169555
95Abnormality of the renal medulla (HP:0100957)1.72472702
96Ectopic kidney (HP:0000086)1.70871002
97Abnormality of pyrimidine metabolism (HP:0004353)1.68359009
98Metatarsus adductus (HP:0001840)1.68320396
99Postural instability (HP:0002172)1.67750950
100Loss of speech (HP:0002371)1.66849678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.24180514
2FRK3.37541299
3BMPR1B3.28941670
4ADRBK22.77615952
5NTRK32.49038089
6STK392.28116725
7EPHB22.25480379
8TAOK32.20605780
9NUAK12.02666437
10ILK2.01322983
11OXSR11.98705542
12VRK11.94732620
13MYLK1.93842840
14CDK31.92719275
15GRK11.88705781
16CSNK1G11.88067426
17NLK1.87758465
18ACVR1B1.85292065
19MAP3K21.84779972
20STK241.78977540
21TGFBR11.76380291
22RAF11.73259296
23MAP3K41.64161250
24MAP2K71.52485300
25WNK31.46235525
26RET1.44177892
27BRSK21.29193288
28TLK11.28211628
29IKBKE1.19291861
30MST41.18986377
31MAPK71.17028987
32CSNK1G31.16486023
33ADRBK11.16114443
34PRKCE1.11921429
35MAP3K31.09389686
36KIT1.07697943
37PTK2B1.03616871
38DDR21.03535357
39MAP3K121.01370294
40ROCK21.00416267
41MET1.00095712
42NEK20.96316991
43CSNK1A1L0.95656841
44EPHA30.92806773
45FGFR20.92437202
46SGK20.85629242
47CSNK1G20.85602766
48PAK30.81539342
49MAP4K20.78161716
50MAPKAPK50.76979887
51MAPK120.76493864
52DMPK0.73382546
53DAPK20.72209210
54ZAK0.70689182
55CAMK2B0.68001920
56PIK3CA0.65516550
57CSNK1D0.64171101
58KSR20.61651607
59PRKCQ0.60703842
60CAMK2D0.59937276
61TIE10.59001363
62SRPK10.58853037
63PRKG10.56504211
64MAP2K10.56306317
65ROCK10.56249823
66STK110.55927710
67PRKACB0.53019630
68PAK20.51879507
69OBSCN0.51805068
70GSK3A0.51197092
71CAMK2G0.49070778
72MAP2K60.48740997
73PASK0.48424797
74PKN10.48272025
75WEE10.47850408
76INSRR0.46406478
77PDGFRB0.46212517
78NEK90.43346182
79TEC0.39871339
80PRKD10.39438027
81BTK0.39199576
82CSNK1E0.38732033
83PTK20.38656397
84WNK10.38017040
85GRK60.36949841
86FLT30.36884291
87CSNK1A10.36881512
88INSR0.35932323
89SGK4940.34303566
90SGK2230.34303566
91CAMK2A0.34032008
92IKBKB0.33694514
93TNIK0.33494135
94NEK10.33335515
95STK38L0.32750066
96SGK10.32533018
97MAPK10.32478558
98PRKACA0.32319606
99DYRK20.32264054
100PRKCD0.27897332

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004504.39508866
2Phototransduction_Homo sapiens_hsa047443.36573386
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.12316974
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.51271079
5cGMP-PKG signaling pathway_Homo sapiens_hsa040222.45333527
6Collecting duct acid secretion_Homo sapiens_hsa049662.36813801
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.26638245
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25288051
9Ether lipid metabolism_Homo sapiens_hsa005652.10907075
10Ribosome_Homo sapiens_hsa030102.07435187
11Salivary secretion_Homo sapiens_hsa049701.90512171
12Vascular smooth muscle contraction_Homo sapiens_hsa042701.86919994
13Linoleic acid metabolism_Homo sapiens_hsa005911.80136514
14Renin secretion_Homo sapiens_hsa049241.79130611
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.76769781
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73119758
17Olfactory transduction_Homo sapiens_hsa047401.73038867
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.60608173
19Circadian entrainment_Homo sapiens_hsa047131.56283461
20Long-term depression_Homo sapiens_hsa047301.55505055
21Regulation of autophagy_Homo sapiens_hsa041401.52542318
22Morphine addiction_Homo sapiens_hsa050321.49572543
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46165823
24Cardiac muscle contraction_Homo sapiens_hsa042601.43876364
25ABC transporters_Homo sapiens_hsa020101.42237956
26Protein export_Homo sapiens_hsa030601.41023261
27Purine metabolism_Homo sapiens_hsa002301.40929046
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39641899
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36099702
30GABAergic synapse_Homo sapiens_hsa047271.27933391
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26594322
32Oxidative phosphorylation_Homo sapiens_hsa001901.25658317
33Vibrio cholerae infection_Homo sapiens_hsa051101.22651586
34Basal cell carcinoma_Homo sapiens_hsa052171.21711651
35Gastric acid secretion_Homo sapiens_hsa049711.17977433
36Gap junction_Homo sapiens_hsa045401.16589350
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16275946
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09549349
39Cocaine addiction_Homo sapiens_hsa050301.07651407
40Platelet activation_Homo sapiens_hsa046111.04023981
41Ovarian steroidogenesis_Homo sapiens_hsa049131.01281166
42Taste transduction_Homo sapiens_hsa047421.00896125
43Hedgehog signaling pathway_Homo sapiens_hsa043400.98563746
44Basal transcription factors_Homo sapiens_hsa030220.97691709
45cAMP signaling pathway_Homo sapiens_hsa040240.95259922
46Parkinsons disease_Homo sapiens_hsa050120.95079088
47Nicotine addiction_Homo sapiens_hsa050330.94147465
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91278788
49Synaptic vesicle cycle_Homo sapiens_hsa047210.90140666
50Fanconi anemia pathway_Homo sapiens_hsa034600.89716738
51Calcium signaling pathway_Homo sapiens_hsa040200.89255389
52Tryptophan metabolism_Homo sapiens_hsa003800.89203646
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88427362
54ECM-receptor interaction_Homo sapiens_hsa045120.88056875
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87768592
56Serotonergic synapse_Homo sapiens_hsa047260.87633060
57Arachidonic acid metabolism_Homo sapiens_hsa005900.84608875
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84263888
59Dorso-ventral axis formation_Homo sapiens_hsa043200.83056489
60Nitrogen metabolism_Homo sapiens_hsa009100.82764684
61Butanoate metabolism_Homo sapiens_hsa006500.80578895
62Dopaminergic synapse_Homo sapiens_hsa047280.75480044
63Inositol phosphate metabolism_Homo sapiens_hsa005620.74993390
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74734811
65RNA polymerase_Homo sapiens_hsa030200.74222153
66Bile secretion_Homo sapiens_hsa049760.73716874
67Mineral absorption_Homo sapiens_hsa049780.67685819
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66921492
69Insulin secretion_Homo sapiens_hsa049110.64405468
70Oxytocin signaling pathway_Homo sapiens_hsa049210.61015499
71Glutamatergic synapse_Homo sapiens_hsa047240.56621915
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56442288
73Hippo signaling pathway_Homo sapiens_hsa043900.55416706
74Circadian rhythm_Homo sapiens_hsa047100.54908336
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54863615
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53949717
77Sphingolipid metabolism_Homo sapiens_hsa006000.53540298
78Pancreatic secretion_Homo sapiens_hsa049720.52176992
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48303060
80Type II diabetes mellitus_Homo sapiens_hsa049300.47901173
81Chemical carcinogenesis_Homo sapiens_hsa052040.47193999
82Protein digestion and absorption_Homo sapiens_hsa049740.46294118
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.46002994
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45154251
85Base excision repair_Homo sapiens_hsa034100.44228813
86Alzheimers disease_Homo sapiens_hsa050100.44115669
87Amphetamine addiction_Homo sapiens_hsa050310.44048588
88Thyroid hormone synthesis_Homo sapiens_hsa049180.44016592
89Caffeine metabolism_Homo sapiens_hsa002320.41788802
90Peroxisome_Homo sapiens_hsa041460.39363007
91Cholinergic synapse_Homo sapiens_hsa047250.39251936
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38500868
93Sulfur metabolism_Homo sapiens_hsa009200.37078540
94Fat digestion and absorption_Homo sapiens_hsa049750.32668677
95Oocyte meiosis_Homo sapiens_hsa041140.30229387
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29237206
97Huntingtons disease_Homo sapiens_hsa050160.28879469
98Non-homologous end-joining_Homo sapiens_hsa034500.27650280
99Pertussis_Homo sapiens_hsa051330.27514485
100Tight junction_Homo sapiens_hsa045300.26874496

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