ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cell communication by electrical coupling (GO:0010649)	4.10773794
2	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	4.03681441
3	NADH metabolic process (GO:0006734)	3.91573515
4	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	3.64652453
5	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.62712326
6	regulation of female receptivity (GO:0045924)	3.61914436
7	epoxygenase P450 pathway (GO:0019373)	3.48537865
8	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.45666967
9	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.43719427
10	regulation of guanylate cyclase activity (GO:0031282)	3.42606344
11	regulation of relaxation of muscle (GO:1901077)	3.40445476
12	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.38471212
13	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.33282576
14	detection of calcium ion (GO:0005513)	3.27114299
15	carnitine shuttle (GO:0006853)	3.18559952
16	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.15720684
17	drug catabolic process (GO:0042737)	3.15374696
18	regulation of lipoprotein metabolic process (GO:0050746)	3.13909729
19	female mating behavior (GO:0060180)	3.13007016
20	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.12390132
21	actin-myosin filament sliding (GO:0033275)	3.11996727
22	muscle filament sliding (GO:0030049)	3.11996727
23	regulation of oxidative phosphorylation (GO:0002082)	3.09955981
24	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.09526628
25	L-phenylalanine catabolic process (GO:0006559)	3.09526628
26	fatty acid transmembrane transport (GO:1902001)	3.06532308
27	sleep (GO:0030431)	2.97386251
28	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.95907581
29	L-phenylalanine metabolic process (GO:0006558)	2.95907581
30	cGMP-mediated signaling (GO:0019934)	2.95880598
31	negative regulation of protein localization to cell surface (GO:2000009)	2.95155528
32	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.94776935
33	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.93265081
34	intestinal absorption (GO:0050892)	2.92353931
35	cardiac muscle hypertrophy (GO:0003300)	2.89633327
36	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.89582907
37	positive regulation of guanylate cyclase activity (GO:0031284)	2.89508802
38	relaxation of cardiac muscle (GO:0055119)	2.88941273
39	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.86680661
40	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.86680661
41	regulation of skeletal muscle contraction (GO:0014819)	2.85313357
42	creatine metabolic process (GO:0006600)	2.83041682
43	actin-mediated cell contraction (GO:0070252)	2.81907184
44	striated muscle hypertrophy (GO:0014897)	2.81026981
45	cardiac conduction (GO:0061337)	2.78673663
46	exogenous drug catabolic process (GO:0042738)	2.77833041
47	cardiac muscle contraction (GO:0060048)	2.77576281
48	skeletal muscle contraction (GO:0003009)	2.73261735
49	striated muscle contraction (GO:0006941)	2.72550430
50	acylglycerol homeostasis (GO:0055090)	2.72354647
51	triglyceride homeostasis (GO:0070328)	2.72354647
52	regulation of triglyceride catabolic process (GO:0010896)	2.72326344
53	transcytosis (GO:0045056)	2.71427104
54	cardiac muscle hypertrophy in response to stress (GO:0014898)	2.70698465
55	muscle hypertrophy in response to stress (GO:0003299)	2.70698465
56	cardiac muscle adaptation (GO:0014887)	2.70698465
57	ethanol oxidation (GO:0006069)	2.69375144
58	relaxation of muscle (GO:0090075)	2.67476032
59	regulation of sequestering of triglyceride (GO:0010889)	2.67337974
60	negative regulation of heart rate (GO:0010459)	2.66652731
61	regulation of bile acid biosynthetic process (GO:0070857)	2.62846617
62	positive regulation of glycolytic process (GO:0045821)	2.62492803
63	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.61878400
64	blood coagulation, intrinsic pathway (GO:0007597)	2.61400166
65	respiratory electron transport chain (GO:0022904)	2.56598885
66	fatty acid homeostasis (GO:0055089)	2.55110061
67	electron transport chain (GO:0022900)	2.54516706
68	regulation of cGMP biosynthetic process (GO:0030826)	2.53721704
69	regulation of clathrin-mediated endocytosis (GO:2000369)	2.52081493
70	vitamin transmembrane transport (GO:0035461)	2.51252856
71	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.51233935
72	regulation of actin filament-based movement (GO:1903115)	2.50858181
73	myofibril assembly (GO:0030239)	2.50261918
74	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.48154676
75	drug metabolic process (GO:0017144)	2.41322410
76	oxaloacetate metabolic process (GO:0006107)	2.41003183
77	cardiac muscle cell action potential involved in contraction (GO:0086002)	2.40604835
78	cardiac muscle cell action potential (GO:0086001)	2.37849124
79	amino-acid betaine transport (GO:0015838)	2.37444487
80	carnitine transport (GO:0015879)	2.37444487
81	regulation of calcium ion transmembrane transporter activity (GO:1901019)	2.37305921
82	regulation of calcium ion transmembrane transport (GO:1903169)	2.37305921
83	cell communication involved in cardiac conduction (GO:0086065)	2.36757906
84	positive regulation of lipoprotein lipase activity (GO:0051006)	2.36060519
85	positive regulation of triglyceride lipase activity (GO:0061365)	2.36060519
86	cellular glucuronidation (GO:0052695)	2.35959108
87	flavonoid metabolic process (GO:0009812)	2.35904747
88	regulation of membrane repolarization (GO:0060306)	2.34674207
89	regulation of sodium ion transmembrane transporter activity (GO:2000649)	2.34349563
90	positive regulation of sodium ion transport (GO:0010765)	2.34277497
91	muscle hypertrophy (GO:0014896)	2.33106377
92	carnitine transmembrane transport (GO:1902603)	2.30619483
93	regulation of energy homeostasis (GO:2000505)	2.29885818
94	angiotensin maturation (GO:0002003)	2.29126835
95	cell communication by electrical coupling (GO:0010644)	2.28070168
96	regulation of striated muscle contraction (GO:0006942)	2.27980121
97	positive regulation of cellular amine metabolic process (GO:0033240)	2.26593524
98	cGMP metabolic process (GO:0046068)	2.24346272
99	striated muscle adaptation (GO:0014888)	2.23656933
100	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.23572482

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.71892834
2	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.68750229
3	VDR_22108803_ChIP-Seq_LS180_Human	2.16908337
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08817973
5	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.08797726
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.94581422
7	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.90666054
8	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.86402350
9	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.85252829
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83009502
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79425043
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.78563301
13	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.75247127
14	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.67285667
15	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.61166807
16	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.59264749
17	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.58188871
18	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.57906983
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.53044279
20	EZH2_22144423_ChIP-Seq_EOC_Human	1.49530534
21	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.48053017
22	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.45483354
23	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.42415349
24	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.37186722
25	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.35206585
26	DROSHA_22980978_ChIP-Seq_HELA_Human	1.34986737
27	GATA4_25053715_ChIP-Seq_YYC3_Human	1.32769150
28	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.31403667
29	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.30807504
30	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.30437412
31	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.30255775
32	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.30241143
33	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.29603512
34	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.28916646
35	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28728862
36	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.26659592
37	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.24332152
38	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.15381684
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.13844619
40	GATA1_22025678_ChIP-Seq_K562_Human	1.13350650
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.13328568
42	CDX2_22108803_ChIP-Seq_LS180_Human	1.11851204
43	SOX2_20726797_ChIP-Seq_SW620_Human	1.09667266
44	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.08432379
45	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.07933142
46	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.07907444
47	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06190027
48	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.05091631
49	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04210592
50	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.02146121
51	HTT_18923047_ChIP-ChIP_STHdh_Human	1.02089680
52	TCF4_23295773_ChIP-Seq_U87_Human	1.01081175
53	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.99119717
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97968406
55	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.97874647
56	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.97741566
57	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.97505079
58	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.97243221
59	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.97243221
60	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97108505
61	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.96761200
62	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96656030
63	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96656030
64	RBPJ_21746931_ChIP-Seq_IB4_Human	0.96201217
65	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.96197560
66	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.94905761
67	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.94304750
68	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.93781870
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.93500078
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.93491461
71	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93461413
72	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.93457708
73	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.93285437
74	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.93084812
75	PHF8_20622853_ChIP-Seq_HELA_Human	0.92897128
76	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.92755525
77	TCF4_22108803_ChIP-Seq_LS180_Human	0.92418316
78	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.91717355
79	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.91590653
80	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.91455016
81	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.91409318
82	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.91346346
83	STAT1_20625510_ChIP-Seq_HELA_Human	0.89440536
84	SMAD4_21799915_ChIP-Seq_A2780_Human	0.89339999
85	AR_25329375_ChIP-Seq_VCAP_Human	0.88943341
86	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.88335637
87	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.88300688
88	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.87237130
89	TBL1_22424771_ChIP-Seq_293T_Human	0.86687572
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.86669541
91	NFYB_21822215_ChIP-Seq_K562_Human	0.85328367
92	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.84593293
93	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.84549450
94	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.83157313
95	GATA2_19941826_ChIP-Seq_K562_Human	0.81478811
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.81451864
97	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.81394853
98	GATA6_25053715_ChIP-Seq_YYC3_Human	0.81309042
99	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.81302196
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.80896355

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	3.55369901
2	MP0002139_abnormal_hepatobiliary_system	3.09184469
3	MP0004215_abnormal_myocardial_fiber	3.03434629
4	MP0005670_abnormal_white_adipose	3.03329561
5	MP0004036_abnormal_muscle_relaxation	2.66205774
6	MP0004084_abnormal_cardiac_muscle	2.49495889
7	MP0009780_abnormal_chondrocyte_physiolo	2.48256223
8	MP0005365_abnormal_bile_salt	2.46460325
9	MP0000751_myopathy	2.46422817
10	MP0004043_abnormal_pH_regulation	2.43667208
11	MP0010329_abnormal_lipoprotein_level	2.37166738
12	MP0006036_abnormal_mitochondrial_physio	2.34164190
13	MP0005085_abnormal_gallbladder_physiolo	2.32388194
14	MP0002837_dystrophic_cardiac_calcinosis	2.22230775
15	MP0004130_abnormal_muscle_cell	2.08938466
16	MP0002876_abnormal_thyroid_physiology	2.04940038
17	MP0002138_abnormal_hepatobiliary_system	1.98606014
18	MP0003646_muscle_fatigue	1.96494790
19	MP0008872_abnormal_physiological_respon	1.95150525
20	MP0003879_abnormal_hair_cell	1.95086347
21	MP0001501_abnormal_sleep_pattern	1.90857493
22	MP0006138_congestive_heart_failure	1.88037062
23	MP0001666_abnormal_nutrient_absorption	1.87178580
24	MP0004484_altered_response_of	1.86537559
25	MP0008775_abnormal_heart_ventricle	1.80009076
26	MP0003195_calcinosis	1.78649776
27	MP0002972_abnormal_cardiac_muscle	1.72575472
28	MP0001544_abnormal_cardiovascular_syste	1.70589648
29	MP0005385_cardiovascular_system_phenoty	1.70589648
30	MP0005464_abnormal_platelet_physiology	1.69997029
31	MP0005535_abnormal_body_temperature	1.68192982
32	MP0005332_abnormal_amino_acid	1.63905248
33	MP0004019_abnormal_vitamin_homeostasis	1.63134012
34	MP0008875_abnormal_xenobiotic_pharmacok	1.62372741
35	MP0005620_abnormal_muscle_contractility	1.61355531
36	MP0005330_cardiomyopathy	1.59954315
37	MP0008004_abnormal_stomach_pH	1.58720331
38	MP0002118_abnormal_lipid_homeostasis	1.58246006
39	MP0004859_abnormal_synaptic_plasticity	1.55571705
40	MP0005646_abnormal_pituitary_gland	1.51380612
41	MP0004510_myositis	1.50236288
42	MP0000230_abnormal_systemic_arterial	1.48515426
43	MP0004085_abnormal_heartbeat	1.45177278
44	MP0004270_analgesia	1.40028261
45	MP0003806_abnormal_nucleotide_metabolis	1.40021883
46	MP0003137_abnormal_impulse_conducting	1.36372282
47	MP0001765_abnormal_ion_homeostasis	1.33809950
48	MP0009745_abnormal_behavioral_response	1.32856349
49	MP0009840_abnormal_foam_cell	1.30887338
50	MP0002971_abnormal_brown_adipose	1.29527364
51	MP0004145_abnormal_muscle_electrophysio	1.28048596
52	MP0002106_abnormal_muscle_physiology	1.27262510
53	MP0001664_abnormal_digestion	1.26247202
54	MP0004087_abnormal_muscle_fiber	1.22423432
55	MP0002064_seizures	1.21351422
56	MP0002272_abnormal_nervous_system	1.21153627
57	MP0001486_abnormal_startle_reflex	1.17852263
58	MP0005409_darkened_coat_color	1.17126353
59	MP0005166_decreased_susceptibility_to	1.16994216
60	MP0003183_abnormal_peptide_metabolism	1.15453860
61	MP0003868_abnormal_feces_composition	1.14829017
62	MP0005448_abnormal_energy_balance	1.13936159
63	MP0009643_abnormal_urine_homeostasis	1.13052965
64	MP0004885_abnormal_endolymph	1.10722244
65	MP0001440_abnormal_grooming_behavior	1.10408978
66	MP0005369_muscle_phenotype	1.10350977
67	MP0001986_abnormal_taste_sensitivity	1.08623453
68	MP0002127_abnormal_cardiovascular_syste	1.06528916
69	MP0000749_muscle_degeneration	1.04841414
70	MP0000013_abnormal_adipose_tissue	1.04304192
71	MP0002078_abnormal_glucose_homeostasis	1.02710921
72	MP0000678_abnormal_parathyroid_gland	1.00156268
73	MP0010155_abnormal_intestine_physiology	0.97400556
74	MP0005451_abnormal_body_composition	0.96550890
75	MP0005167_abnormal_blood-brain_barrier	0.96041179
76	MP0005666_abnormal_adipose_tissue	0.95715742
77	MP0001756_abnormal_urination	0.94365662
78	MP0003252_abnormal_bile_duct	0.93292364
79	MP0003638_abnormal_response/metabolism_	0.93137668
80	MP0008569_lethality_at_weaning	0.91794441
81	MP0005083_abnormal_biliary_tract	0.91256997
82	MP0009046_muscle_twitch	0.90098454
83	MP0001502_abnormal_circadian_rhythm	0.89222694
84	MP0003724_increased_susceptibility_to	0.88636092
85	MP0005636_abnormal_mineral_homeostasis	0.88231977
86	MP0003635_abnormal_synaptic_transmissio	0.88033223
87	MP0002733_abnormal_thermal_nociception	0.87914277
88	MP0005375_adipose_tissue_phenotype	0.85212822
89	MP0003828_pulmonary_edema	0.84773845
90	MP0000747_muscle_weakness	0.83565941
91	MP0005165_increased_susceptibility_to	0.83435442
92	MP0001764_abnormal_homeostasis	0.81674709
93	MP0001485_abnormal_pinna_reflex	0.80740040
94	MP0001968_abnormal_touch/_nociception	0.80301641
95	MP0002572_abnormal_emotion/affect_behav	0.80150490
96	MP0003866_abnormal_defecation	0.79591445
97	MP0003172_abnormal_lysosome_physiology	0.79031268
98	MP0004147_increased_porphyrin_level	0.78595963
99	MP0009115_abnormal_fat_cell	0.77512314
100	MP0001970_abnormal_pain_threshold	0.77090964

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Bundle branch block (HP:0011710)	4.85082577
2	Nemaline bodies (HP:0003798)	4.18100115
3	Muscle fiber inclusion bodies (HP:0100299)	4.10270895
4	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.91663456
5	Muscle fiber splitting (HP:0003555)	3.65991119
6	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.61247608
7	Hyperlipoproteinemia (HP:0010980)	3.60509560
8	Hyporeflexia of lower limbs (HP:0002600)	3.53951944
9	Decreased circulating renin level (HP:0003351)	3.53116178
10	Ventricular fibrillation (HP:0001663)	3.50531990
11	Prolonged bleeding time (HP:0003010)	3.50008163
12	Heart block (HP:0012722)	3.48761101
13	Sudden death (HP:0001699)	3.44480755
14	Syncope (HP:0001279)	3.39496482
15	Hydroxyprolinuria (HP:0003080)	3.19172567
16	Abnormality of proline metabolism (HP:0010907)	3.19172567
17	Abnormal atrioventricular conduction (HP:0005150)	3.12953858
18	Petechiae (HP:0000967)	3.09855169
19	Hypoglycemic coma (HP:0001325)	3.08162780
20	Abnormality of renin-angiotensin system (HP:0000847)	2.95012321
21	Exercise-induced myalgia (HP:0003738)	2.91904649
22	Ventricular arrhythmia (HP:0004308)	2.88077192
23	Atrial fibrillation (HP:0005110)	2.85049973
24	Muscle hypertrophy of the lower extremities (HP:0008968)	2.77747805
25	Distal lower limb muscle weakness (HP:0009053)	2.71234806
26	EMG: myopathic abnormalities (HP:0003458)	2.67807693
27	Right ventricular cardiomyopathy (HP:0011663)	2.67596832
28	Menorrhagia (HP:0000132)	2.65907849
29	Febrile seizures (HP:0002373)	2.65257103
30	Primary atrial arrhythmia (HP:0001692)	2.61633022
31	Xanthomatosis (HP:0000991)	2.59891355
32	Calf muscle hypertrophy (HP:0008981)	2.59395966
33	Metabolic alkalosis (HP:0200114)	2.54446600
34	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.54293886
35	Ventricular tachycardia (HP:0004756)	2.54220239
36	Type 1 muscle fiber predominance (HP:0003803)	2.50161875
37	Palpitations (HP:0001962)	2.49354975
38	Supraventricular tachycardia (HP:0004755)	2.48012328
39	Asymmetric septal hypertrophy (HP:0001670)	2.46156136
40	Myoglobinuria (HP:0002913)	2.39993389
41	Hyperinsulinemic hypoglycemia (HP:0000825)	2.39841577
42	Hyperglycemia (HP:0003074)	2.36276482
43	Late onset (HP:0003584)	2.35574150
44	Atrioventricular block (HP:0001678)	2.35220730
45	Hyperkalemia (HP:0002153)	2.34919917
46	Supraventricular arrhythmia (HP:0005115)	2.34673917
47	Neck muscle weakness (HP:0000467)	2.29938054
48	Purpura (HP:0000979)	2.29902705
49	Increased circulating renin level (HP:0000848)	2.29302366
50	Hypoglycemic seizures (HP:0002173)	2.24810608
51	Hyperglycinuria (HP:0003108)	2.22201814
52	Abnormality of urine glucose concentration (HP:0011016)	2.18736251
53	Glycosuria (HP:0003076)	2.18736251
54	Prolonged partial thromboplastin time (HP:0003645)	2.17279799
55	Malnutrition (HP:0004395)	2.16730998
56	Abnormal EKG (HP:0003115)	2.14229300
57	EMG: neuropathic changes (HP:0003445)	2.13772031
58	Acanthocytosis (HP:0001927)	2.08965134
59	Subaortic stenosis (HP:0001682)	2.08905814
60	Abnormality of the left ventricular outflow tract (HP:0011103)	2.08905814
61	Exercise-induced muscle cramps (HP:0003710)	2.08256395
62	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.06845023
63	Poikilocytosis (HP:0004447)	2.05797964
64	Congenital sensorineural hearing impairment (HP:0008527)	2.05758893
65	Tongue fasciculations (HP:0001308)	2.05167407
66	Dilated cardiomyopathy (HP:0001644)	2.04292025
67	Lipoatrophy (HP:0100578)	2.04123985
68	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.03966177
69	Renal cortical cysts (HP:0000803)	2.01260147
70	Obstructive sleep apnea (HP:0002870)	2.00610418
71	Abnormality of the calf musculature (HP:0001430)	1.98756583
72	Prolonged QT interval (HP:0001657)	1.98170424
73	Pigmentary retinal degeneration (HP:0001146)	1.96320390
74	Complement deficiency (HP:0004431)	1.96309472
75	Ketoacidosis (HP:0001993)	1.96136555
76	Abnormality of potassium homeostasis (HP:0011042)	1.95990401
77	Action tremor (HP:0002345)	1.94520144
78	Areflexia of lower limbs (HP:0002522)	1.93714409
79	Insulin-resistant diabetes mellitus (HP:0000831)	1.92634037
80	Abnormality of lateral ventricle (HP:0030047)	1.92621764
81	Delayed CNS myelination (HP:0002188)	1.90148102
82	Symptomatic seizures (HP:0011145)	1.90126285
83	Generalized aminoaciduria (HP:0002909)	1.89823624
84	Nausea (HP:0002018)	1.89331757
85	Myopathic facies (HP:0002058)	1.88599089
86	Metaphyseal dysplasia (HP:0100255)	1.88569439
87	Confusion (HP:0001289)	1.87516152
88	Epistaxis (HP:0000421)	1.85453932
89	Abnormal pupillary function (HP:0007686)	1.85386683
90	Abnormality of vitamin B metabolism (HP:0004340)	1.82459799
91	Systemic lupus erythematosus (HP:0002725)	1.82415780
92	Clumsiness (HP:0002312)	1.82019610
93	Alkalosis (HP:0001948)	1.81845929
94	Joint hemorrhage (HP:0005261)	1.81568317
95	Hyperphosphatemia (HP:0002905)	1.80710609
96	Rhabdomyolysis (HP:0003201)	1.78736794
97	Diplopia (HP:0000651)	1.78408373
98	Abnormality of binocular vision (HP:0011514)	1.78408373
99	Hypokalemia (HP:0002900)	1.78215020
100	Difficulty running (HP:0009046)	1.78188513

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MYLK	4.23377838
2	MST4	3.44459865
3	FRK	3.05681990
4	RIPK4	2.92439858
5	TAOK3	2.87558505
6	ACVR1B	2.80648924
7	OBSCN	2.71328496
8	NTRK3	2.67635504
9	PHKG1	2.64133110
10	PHKG2	2.64133110
11	DAPK2	2.51999366
12	PINK1	2.29002278
13	RIPK1	2.21377918
14	TNIK	1.99107906
15	AKT3	1.92282585
16	MAPK12	1.70664315
17	STK24	1.61774216
18	GRK1	1.59696338
19	MST1R	1.53594356
20	PAK3	1.50038182
21	MAP3K7	1.49632383
22	DMPK	1.49625102
23	MAPKAPK3	1.43582925
24	OXSR1	1.42723179
25	GRK5	1.36651757
26	TEC	1.35739024
27	MAP3K13	1.26515544
28	PTK2B	1.24499969
29	EPHA2	1.22397535
30	EPHA4	1.19083243
31	PIK3CA	1.19032143
32	MAP2K6	1.18014497
33	PRKAA2	1.16697703
34	STK39	1.14836567
35	BMX	1.10650891
36	BMPR1B	1.06911467
37	MET	1.06048462
38	MAPK7	1.05382237
39	CAMK1	1.05184573
40	TRPM7	1.03796912
41	MAP3K2	1.02620774
42	BMPR2	1.02596603
43	TNK2	0.99352762
44	TTN	0.99061457
45	ZAP70	0.97056536
46	DAPK1	0.95962813
47	WNK4	0.93461676
48	NME1	0.91725240
49	ADRBK2	0.90808913
50	CAMK2A	0.90729274
51	CDC42BPA	0.90717966
52	MAP3K12	0.89181132
53	MAPK15	0.87039452
54	MAP2K1	0.86294021
55	PIK3CG	0.84260816
56	NLK	0.84149823
57	CAMK2D	0.82172470
58	TXK	0.81656588
59	CAMK2G	0.74305044
60	PDK1	0.71297200
61	ITK	0.70997403
62	PRKG2	0.69972740
63	STK3	0.69773155
64	PRKD1	0.67430728
65	PRKG1	0.66806796
66	SYK	0.66058329
67	CAMK2B	0.64120054
68	PRKCE	0.64108392
69	PRKAA1	0.63564285
70	PDPK1	0.62432359
71	ERBB2	0.56708652
72	PRKACG	0.55851859
73	SGK1	0.54335181
74	HIPK2	0.53371512
75	STK38	0.52782283
76	PRKCA	0.52058058
77	PKN1	0.50945935
78	ROCK1	0.50290518
79	ERN1	0.48574850
80	PRKCG	0.48411339
81	MAP3K1	0.45205102
82	PRKACA	0.44152085
83	BLK	0.43494208
84	CDK12	0.40194806
85	MUSK	0.39917760
86	RPS6KA3	0.39502310
87	MAP3K3	0.38981074
88	CAMKK1	0.38624251
89	CDK19	0.36484940
90	PDK2	0.36141220
91	TIE1	0.36118770
92	IGF1R	0.35885688
93	STK38L	0.34807269
94	FGFR3	0.34371018
95	PRKCQ	0.33475270
96	PTK2	0.32744165
97	MAPK11	0.32487956
98	ADRBK1	0.32184727
99	CAMK4	0.32113233
100	DAPK3	0.32074644

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.27563790
2	Fat digestion and absorption_Homo sapiens_hsa04975	2.19049361
3	Histidine metabolism_Homo sapiens_hsa00340	2.11430770
4	Sulfur metabolism_Homo sapiens_hsa00920	2.08721594
5	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.05970538
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.99879068
7	Insulin secretion_Homo sapiens_hsa04911	1.99344015
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.88506968
9	PPAR signaling pathway_Homo sapiens_hsa03320	1.86985135
10	Arginine biosynthesis_Homo sapiens_hsa00220	1.84836717
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79256098
12	Bile secretion_Homo sapiens_hsa04976	1.76607446
13	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.73522979
14	Fatty acid degradation_Homo sapiens_hsa00071	1.67701557
15	Renin secretion_Homo sapiens_hsa04924	1.62430426
16	Retinol metabolism_Homo sapiens_hsa00830	1.61823169
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.61634874
18	Caffeine metabolism_Homo sapiens_hsa00232	1.56064290
19	Arginine and proline metabolism_Homo sapiens_hsa00330	1.56018155
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.53715935
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.48229853
22	Pancreatic secretion_Homo sapiens_hsa04972	1.45658391
23	Circadian rhythm_Homo sapiens_hsa04710	1.43951419
24	Phenylalanine metabolism_Homo sapiens_hsa00360	1.43178284
25	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.42265790
26	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.41570370
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.40450195
28	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.39322597
29	Glycerolipid metabolism_Homo sapiens_hsa00561	1.38540195
30	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.35891871
31	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.32773675
32	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.28358400
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.26536819
34	Mineral absorption_Homo sapiens_hsa04978	1.26102279
35	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.26058515
36	Collecting duct acid secretion_Homo sapiens_hsa04966	1.25111501
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.23284003
38	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.21329791
39	Amphetamine addiction_Homo sapiens_hsa05031	1.20824771
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.15537901
41	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.14554357
42	Gastric acid secretion_Homo sapiens_hsa04971	1.13097765
43	Circadian entrainment_Homo sapiens_hsa04713	1.12986772
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.10046513
45	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.09607885
46	Renin-angiotensin system_Homo sapiens_hsa04614	1.08838365
47	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.06890533
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.04006647
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03502778
50	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.02151507
51	Morphine addiction_Homo sapiens_hsa05032	1.00648735
52	Salivary secretion_Homo sapiens_hsa04970	1.00296421
53	Calcium signaling pathway_Homo sapiens_hsa04020	0.99571663
54	Serotonergic synapse_Homo sapiens_hsa04726	0.95369451
55	Fatty acid elongation_Homo sapiens_hsa00062	0.95341959
56	Long-term potentiation_Homo sapiens_hsa04720	0.94647434
57	Butanoate metabolism_Homo sapiens_hsa00650	0.92747754
58	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.89974856
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.89969656
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88448799
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.87372696
62	GABAergic synapse_Homo sapiens_hsa04727	0.87321088
63	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.85163026
64	Insulin resistance_Homo sapiens_hsa04931	0.84888796
65	Olfactory transduction_Homo sapiens_hsa04740	0.83968355
66	Tyrosine metabolism_Homo sapiens_hsa00350	0.83857363
67	Glucagon signaling pathway_Homo sapiens_hsa04922	0.83129833
68	Phototransduction_Homo sapiens_hsa04744	0.80990634
69	Platelet activation_Homo sapiens_hsa04611	0.80319782
70	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.76655272
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75489740
72	Asthma_Homo sapiens_hsa05310	0.73311481
73	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.72900753
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72345895
75	cAMP signaling pathway_Homo sapiens_hsa04024	0.72047059
76	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.69668856
77	Complement and coagulation cascades_Homo sapiens_hsa04610	0.68395922
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68057549
79	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.67082100
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.66186245
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63297654
82	ABC transporters_Homo sapiens_hsa02010	0.63093213
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.62756981
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.61919092
85	Propanoate metabolism_Homo sapiens_hsa00640	0.60888074
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.60162338
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59855716
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.59364871
89	Peroxisome_Homo sapiens_hsa04146	0.58541321
90	Cocaine addiction_Homo sapiens_hsa05030	0.58123804
91	Dopaminergic synapse_Homo sapiens_hsa04728	0.57450720
92	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.56832798
93	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.56768227
94	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.56536243
95	Cholinergic synapse_Homo sapiens_hsa04725	0.56423374
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.50231747
97	Protein digestion and absorption_Homo sapiens_hsa04974	0.49197343
98	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.47841773
99	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.47650685
100	Insulin signaling pathway_Homo sapiens_hsa04910	0.46933903

MTND2P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »