ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of glycolytic process (GO:0045821)	5.63094416
2	DNA deamination (GO:0045006)	5.28621969
3	protein K6-linked ubiquitination (GO:0085020)	4.98619963
4	positive regulation of meiosis (GO:0045836)	4.56011971
5	positive regulation of meiotic cell cycle (GO:0051446)	4.38383278
6	protein neddylation (GO:0045116)	4.25665799
7	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.22683998
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.06004668
9	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	4.02199758
10	keratinocyte development (GO:0003334)	3.84751552
11	glycerophospholipid catabolic process (GO:0046475)	3.82643891
12	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.81285538
13	L-methionine salvage (GO:0071267)	3.77693420
14	L-methionine biosynthetic process (GO:0071265)	3.77693420
15	amino acid salvage (GO:0043102)	3.77693420
16	response to pheromone (GO:0019236)	3.77250957
17	negative regulation of gluconeogenesis (GO:0045721)	3.72050257
18	regulation of acrosome reaction (GO:0060046)	3.69090069
19	respiratory chain complex IV assembly (GO:0008535)	3.65133021
20	adaptation of signaling pathway (GO:0023058)	3.63880993
21	inositol phosphate-mediated signaling (GO:0048016)	3.62983034
22	positive regulation of respiratory burst (GO:0060267)	3.56746375
23	nitric oxide mediated signal transduction (GO:0007263)	3.53237465
24	fatty acid homeostasis (GO:0055089)	3.45796795
25	regulation of oxidative phosphorylation (GO:0002082)	3.43893868
26	negative regulation of heart rate (GO:0010459)	3.41038658
27	rRNA methylation (GO:0031167)	3.34959868
28	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.32344830
29	negative regulation of hormone biosynthetic process (GO:0032353)	3.25346788
30	nucleoside diphosphate catabolic process (GO:0009134)	3.22617096
31	L-fucose catabolic process (GO:0042355)	3.20985071
32	fucose catabolic process (GO:0019317)	3.20985071
33	L-fucose metabolic process (GO:0042354)	3.20985071
34	exogenous drug catabolic process (GO:0042738)	3.18230949
35	methionine biosynthetic process (GO:0009086)	3.16799894
36	negative regulation of mast cell activation (GO:0033004)	3.15121452
37	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	3.14359740
38	aggressive behavior (GO:0002118)	3.14188504
39	preassembly of GPI anchor in ER membrane (GO:0016254)	3.13779987
40	positive regulation of protein homodimerization activity (GO:0090073)	3.13739752
41	organic cation transport (GO:0015695)	3.13338314
42	regulation of energy homeostasis (GO:2000505)	3.10730657
43	negative regulation of acute inflammatory response (GO:0002674)	3.09754707
44	signal peptide processing (GO:0006465)	3.09391810
45	azole transport (GO:0045117)	3.06206774
46	rRNA modification (GO:0000154)	3.05565057
47	piRNA metabolic process (GO:0034587)	3.04308614
48	kynurenine metabolic process (GO:0070189)	3.02050969
49	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.96210280
50	lactate metabolic process (GO:0006089)	2.92345131
51	reflex (GO:0060004)	2.91908250
52	behavioral response to nicotine (GO:0035095)	2.89891165
53	positive regulation of fatty acid transport (GO:2000193)	2.89484517
54	histamine transport (GO:0051608)	2.89101484
55	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.89045587
56	RNA destabilization (GO:0050779)	2.86706348
57	phasic smooth muscle contraction (GO:0014821)	2.85948417
58	detection of light stimulus involved in visual perception (GO:0050908)	2.85331495
59	detection of light stimulus involved in sensory perception (GO:0050962)	2.85331495
60	endocrine pancreas development (GO:0031018)	2.84051568
61	adult feeding behavior (GO:0008343)	2.83019388
62	regulation of hexokinase activity (GO:1903299)	2.80304562
63	regulation of glucokinase activity (GO:0033131)	2.80304562
64	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.80178843
65	negative regulation of glycogen metabolic process (GO:0070874)	2.77310017
66	somite rostral/caudal axis specification (GO:0032525)	2.77030203
67	protein-cofactor linkage (GO:0018065)	2.76340107
68	glandular epithelial cell differentiation (GO:0002067)	2.73863205
69	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.72456265
70	type B pancreatic cell development (GO:0003323)	2.71185082
71	DNA double-strand break processing (GO:0000729)	2.71059505
72	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.68788806
73	negative regulation of hormone metabolic process (GO:0032351)	2.67028375
74	indole-containing compound catabolic process (GO:0042436)	2.66920162
75	indolalkylamine catabolic process (GO:0046218)	2.66920162
76	tryptophan catabolic process (GO:0006569)	2.66920162
77	regulation of neurotransmitter uptake (GO:0051580)	2.66200505
78	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.64584834
79	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.64088902
80	arginine catabolic process (GO:0006527)	2.63961070
81	cytochrome complex assembly (GO:0017004)	2.56851951
82	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.56511959
83	rRNA catabolic process (GO:0016075)	2.56288462
84	signal transduction involved in regulation of gene expression (GO:0023019)	2.55531803
85	nitric oxide biosynthetic process (GO:0006809)	2.55360949
86	N-acetylglucosamine metabolic process (GO:0006044)	2.54827626
87	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.54119544
88	positive regulation of prostaglandin secretion (GO:0032308)	2.52445962
89	transcription from mitochondrial promoter (GO:0006390)	2.51380326
90	positive regulation of glycogen biosynthetic process (GO:0045725)	2.50544674
91	pseudouridine synthesis (GO:0001522)	2.49531408
92	aspartate family amino acid biosynthetic process (GO:0009067)	2.49422243
93	DNA methylation involved in gamete generation (GO:0043046)	2.49161647
94	nucleoside transmembrane transport (GO:1901642)	2.48564224
95	indolalkylamine metabolic process (GO:0006586)	2.47636417
96	regulation of glycolytic process (GO:0006110)	2.47242671
97	vitamin transmembrane transport (GO:0035461)	2.46615979
98	kidney morphogenesis (GO:0060993)	2.46083359
99	methionine metabolic process (GO:0006555)	2.44020805
100	endothelium development (GO:0003158)	2.43812617

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.83532010
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.95317839
3	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.76379976
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.65716440
5	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.61361134
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.38802479
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.28360805
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.21591590
9	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.12924593
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12553769
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.08129293
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.05878001
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96283336
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.95902010
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.95770376
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85730736
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.84141909
18	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.79925192
19	EWS_26573619_Chip-Seq_HEK293_Human	1.76998068
20	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.76851945
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73456381
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.69161079
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.68307681
24	P300_19829295_ChIP-Seq_ESCs_Human	1.67642047
25	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.66439930
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.65665201
27	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.64059814
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.63699157
29	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.63603548
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.63299063
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62047317
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.61196454
33	SOX2_19829295_ChIP-Seq_ESCs_Human	1.59897664
34	NANOG_19829295_ChIP-Seq_ESCs_Human	1.59897664
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.57567347
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.54264731
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.54078241
38	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.51886321
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.50646248
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49746969
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.48222032
42	EZH2_22144423_ChIP-Seq_EOC_Human	1.48053194
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.46883198
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.43856605
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42961500
46	HTT_18923047_ChIP-ChIP_STHdh_Human	1.39336907
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37439508
48	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37195305
49	TCF4_23295773_ChIP-Seq_U87_Human	1.36899172
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.36788994
51	AR_25329375_ChIP-Seq_VCAP_Human	1.35988740
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34600720
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32998537
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32998537
55	NCOR_22424771_ChIP-Seq_293T_Human	1.31589436
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31156884
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.31140260
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30962593
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28662470
60	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.26627001
61	CDX2_22108803_ChIP-Seq_LS180_Human	1.25989735
62	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.24988547
63	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24829923
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24561727
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23333648
66	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.20986358
67	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.20558547
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.19610755
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19066148
70	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19051252
71	STAT3_23295773_ChIP-Seq_U87_Human	1.18979416
72	ER_23166858_ChIP-Seq_MCF-7_Human	1.17438854
73	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.14926739
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.13329860
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13329860
76	AR_20517297_ChIP-Seq_VCAP_Human	1.11793325
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11466528
78	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.10862609
79	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09565576
80	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09487455
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08388991
82	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.07924417
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05083960
84	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.04902974
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03933419
86	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03030590
87	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02082518
88	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02008984
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01913675
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01848593
91	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.00099741
92	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99480120
93	JUN_21703547_ChIP-Seq_K562_Human	0.98693441
94	FUS_26573619_Chip-Seq_HEK293_Human	0.98670151
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98515756
96	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97982415
97	SMRT_27268052_Chip-Seq_Bcells_Human	0.97452771
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.96722897
99	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.96712873
100	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95998796

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.21954441
2	MP0003283_abnormal_digestive_organ	4.34179143
3	MP0006054_spinal_hemorrhage	3.25224553
4	MP0002837_dystrophic_cardiac_calcinosis	2.59008339
5	MP0008875_abnormal_xenobiotic_pharmacok	2.54587174
6	MP0005167_abnormal_blood-brain_barrier	2.47403343
7	MP0003567_abnormal_fetal_cardiomyocyte	2.45780758
8	MP0005389_reproductive_system_phenotype	2.39125275
9	MP0004145_abnormal_muscle_electrophysio	2.33892881
10	MP0005645_abnormal_hypothalamus_physiol	2.27849831
11	MP0002102_abnormal_ear_morphology	2.17703220
12	MP0002160_abnormal_reproductive_system	2.17304241
13	MP0008872_abnormal_physiological_respon	2.17088241
14	MP0000647_abnormal_sebaceous_gland	2.09044023
15	MP0006292_abnormal_olfactory_placode	2.00487999
16	MP0004133_heterotaxia	1.95430485
17	MP0001919_abnormal_reproductive_system	1.92195531
18	MP0009046_muscle_twitch	1.91530863
19	MP0003806_abnormal_nucleotide_metabolis	1.89043779
20	MP0001501_abnormal_sleep_pattern	1.88645660
21	MP0004142_abnormal_muscle_tone	1.82405849
22	MP0002163_abnormal_gland_morphology	1.81700738
23	MP0005551_abnormal_eye_electrophysiolog	1.81248648
24	MP0002876_abnormal_thyroid_physiology	1.79861741
25	MP0005379_endocrine/exocrine_gland_phen	1.74459351
26	MP0003786_premature_aging	1.70080724
27	MP0000427_abnormal_hair_cycle	1.66482059
28	MP0004084_abnormal_cardiac_muscle	1.64979257
29	MP0008775_abnormal_heart_ventricle	1.64978083
30	MP0003646_muscle_fatigue	1.63855800
31	MP0008877_abnormal_DNA_methylation	1.62331493
32	MP0001986_abnormal_taste_sensitivity	1.62243016
33	MP0008995_early_reproductive_senescence	1.61439074
34	MP0006276_abnormal_autonomic_nervous	1.61420552
35	MP0002139_abnormal_hepatobiliary_system	1.58742733
36	MP0003943_abnormal_hepatobiliary_system	1.58657743
37	MP0004043_abnormal_pH_regulation	1.53616451
38	MP0003011_delayed_dark_adaptation	1.50887247
39	MP0004885_abnormal_endolymph	1.49506916
40	MP0002277_abnormal_respiratory_mucosa	1.47779755
41	MP0004147_increased_porphyrin_level	1.46968266
42	MP0004215_abnormal_myocardial_fiber	1.46624998
43	MP0001485_abnormal_pinna_reflex	1.43729095
44	MP0000383_abnormal_hair_follicle	1.42288297
45	MP0006036_abnormal_mitochondrial_physio	1.37435225
46	MP0003137_abnormal_impulse_conducting	1.32632753
47	MP0000631_abnormal_neuroendocrine_gland	1.30381483
48	MP0009745_abnormal_behavioral_response	1.28869593
49	MP0002693_abnormal_pancreas_physiology	1.26785984
50	MP0002733_abnormal_thermal_nociception	1.23993571
51	MP0005646_abnormal_pituitary_gland	1.23353731
52	MP0006035_abnormal_mitochondrial_morpho	1.21836643
53	MP0010329_abnormal_lipoprotein_level	1.19602693
54	MP0001944_abnormal_pancreas_morphology	1.18710964
55	MP0001970_abnormal_pain_threshold	1.17445909
56	MP0002272_abnormal_nervous_system	1.17049916
57	MP0001440_abnormal_grooming_behavior	1.14658800
58	MP0005410_abnormal_fertilization	1.12848085
59	MP0000230_abnormal_systemic_arterial	1.11800888
60	MP0005084_abnormal_gallbladder_morpholo	1.05968631
61	MP0001968_abnormal_touch/_nociception	1.05785329
62	MP0003718_maternal_effect	1.05165981
63	MP0003119_abnormal_digestive_system	1.04980566
64	MP0001765_abnormal_ion_homeostasis	1.04466490
65	MP0004484_altered_response_of	1.02982692
66	MP0004036_abnormal_muscle_relaxation	1.02845536
67	MP0002064_seizures	0.99734568
68	MP0005085_abnormal_gallbladder_physiolo	0.99650875
69	MP0005253_abnormal_eye_physiology	0.99527708
70	MP0005220_abnormal_exocrine_pancreas	0.98044821
71	MP0008004_abnormal_stomach_pH	0.94573938
72	MP0005636_abnormal_mineral_homeostasis	0.93660630
73	MP0004782_abnormal_surfactant_physiolog	0.91438306
74	MP0003638_abnormal_response/metabolism_	0.90584959
75	MP0001727_abnormal_embryo_implantation	0.89173408
76	MP0002557_abnormal_social/conspecific_i	0.84042419
77	MP0005595_abnormal_vascular_smooth	0.83978817
78	MP0001486_abnormal_startle_reflex	0.82561987
79	MP0002909_abnormal_adrenal_gland	0.81604470
80	MP0001756_abnormal_urination	0.79588977
81	MP0005448_abnormal_energy_balance	0.78676737
82	MP0002210_abnormal_sex_determination	0.78302162
83	MP0003953_abnormal_hormone_level	0.78300072
84	MP0006072_abnormal_retinal_apoptosis	0.77826942
85	MP0000653_abnormal_sex_gland	0.75626201
86	MP0004134_abnormal_chest_morphology	0.74288823
87	MP0004085_abnormal_heartbeat	0.72872655
88	MP0003635_abnormal_synaptic_transmissio	0.72562895
89	MP0009643_abnormal_urine_homeostasis	0.72238106
90	MP0010678_abnormal_skin_adnexa	0.71218054
91	MP0000470_abnormal_stomach_morphology	0.68877091
92	MP0002572_abnormal_emotion/affect_behav	0.68478983
93	MP0004130_abnormal_muscle_cell	0.67882189
94	MP0005075_abnormal_melanosome_morpholog	0.67726638
95	MP0002928_abnormal_bile_duct	0.66466553
96	MP0002067_abnormal_sensory_capabilities	0.66298722
97	MP0005385_cardiovascular_system_phenoty	0.65538636
98	MP0001544_abnormal_cardiovascular_syste	0.65538636
99	MP0005535_abnormal_body_temperature	0.65362056
100	MP0002736_abnormal_nociception_after	0.64942647

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic seizures (HP:0002173)	5.11722099
2	Hypoglycemic coma (HP:0001325)	4.51107983
3	Hyperinsulinemic hypoglycemia (HP:0000825)	4.02185493
4	Hypomagnesemia (HP:0002917)	3.69127693
5	Aplasia/hypoplasia of the uterus (HP:0008684)	3.58066718
6	Hyperglycemia (HP:0003074)	3.53629494
7	Symptomatic seizures (HP:0011145)	3.41389501
8	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.29350153
9	Hypoplasia of the fovea (HP:0007750)	3.29350153
10	Unilateral renal agenesis (HP:0000122)	3.21797072
11	Abnormality of the pancreatic islet cells (HP:0006476)	3.18319731
12	Abnormality of endocrine pancreas physiology (HP:0012093)	3.18319731
13	Nephronophthisis (HP:0000090)	3.17830588
14	Abnormality of midbrain morphology (HP:0002418)	3.12805240
15	Molar tooth sign on MRI (HP:0002419)	3.12805240
16	Congenital stationary night blindness (HP:0007642)	3.12250258
17	Abnormal pancreas size (HP:0012094)	3.11774786
18	Pancreatic cysts (HP:0001737)	3.09878133
19	Ketoacidosis (HP:0001993)	3.09430010
20	Abnormality of magnesium homeostasis (HP:0004921)	3.08658951
21	Pancreatic fibrosis (HP:0100732)	3.03829921
22	Increased hepatocellular lipid droplets (HP:0006565)	3.00171123
23	Abnormal biliary tract physiology (HP:0012439)	2.99779787
24	Bile duct proliferation (HP:0001408)	2.99779787
25	Large for gestational age (HP:0001520)	2.89860941
26	True hermaphroditism (HP:0010459)	2.82158746
27	Abnormality of the renal medulla (HP:0100957)	2.73733772
28	Lipid accumulation in hepatocytes (HP:0006561)	2.73136155
29	Bilateral microphthalmos (HP:0007633)	2.69882430
30	3-Methylglutaconic aciduria (HP:0003535)	2.68482824
31	Hypoplasia of the uterus (HP:0000013)	2.67273051
32	Abnormality of urine glucose concentration (HP:0011016)	2.64644748
33	Glycosuria (HP:0003076)	2.64644748
34	Genetic anticipation (HP:0003743)	2.64644708
35	Abnormality of the renal cortex (HP:0011035)	2.60635364
36	Adrenal hypoplasia (HP:0000835)	2.56631636
37	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.54511345
38	CNS hypomyelination (HP:0003429)	2.54293329
39	Acute necrotizing encephalopathy (HP:0006965)	2.52672489
40	Broad-based gait (HP:0002136)	2.50934081
41	Tetany (HP:0001281)	2.45704553
42	Conjugated hyperbilirubinemia (HP:0002908)	2.45094097
43	Asplenia (HP:0001746)	2.44256141
44	Abnormal drinking behavior (HP:0030082)	2.44110583
45	Polydipsia (HP:0001959)	2.44110583
46	Supernumerary spleens (HP:0009799)	2.39809924
47	Prominent metopic ridge (HP:0005487)	2.38246424
48	Abnormality of the fovea (HP:0000493)	2.37944941
49	Medial flaring of the eyebrow (HP:0010747)	2.32497127
50	Gaze-evoked nystagmus (HP:0000640)	2.30537462
51	Increased CSF lactate (HP:0002490)	2.30180122
52	Sensory axonal neuropathy (HP:0003390)	2.26202715
53	Decreased central vision (HP:0007663)	2.25338479
54	Tubular atrophy (HP:0000092)	2.23736774
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.23326569
56	Acute encephalopathy (HP:0006846)	2.23000711
57	Premature ovarian failure (HP:0008209)	2.22403944
58	Azoospermia (HP:0000027)	2.21992893
59	Type I diabetes mellitus (HP:0100651)	2.20902115
60	Nephrogenic diabetes insipidus (HP:0009806)	2.20277051
61	Constricted visual fields (HP:0001133)	2.18354286
62	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.16067540
63	Abnormality of alanine metabolism (HP:0010916)	2.16067540
64	Hyperalaninemia (HP:0003348)	2.16067540
65	Progressive macrocephaly (HP:0004481)	2.12525698
66	Abolished electroretinogram (ERG) (HP:0000550)	2.10372614
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.09765033
68	Mitochondrial inheritance (HP:0001427)	2.09377219
69	Congenital hepatic fibrosis (HP:0002612)	2.05483347
70	Sclerocornea (HP:0000647)	2.04481377
71	Renal Fanconi syndrome (HP:0001994)	2.04185879
72	Progressive inability to walk (HP:0002505)	2.03585037
73	Cone-rod dystrophy (HP:0000548)	2.01795237
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01440199
75	Abnormality of the pons (HP:0007361)	2.01438182
76	Pendular nystagmus (HP:0012043)	2.01223392
77	Cerebral hypomyelination (HP:0006808)	2.00129353
78	Severe muscular hypotonia (HP:0006829)	1.98822277
79	Rib fusion (HP:0000902)	1.96867845
80	Ketosis (HP:0001946)	1.95339799
81	Agitation (HP:0000713)	1.93775186
82	Occipital encephalocele (HP:0002085)	1.93679787
83	Abnormality of the metopic suture (HP:0005556)	1.93159361
84	Male pseudohermaphroditism (HP:0000037)	1.92082127
85	Aplasia/Hypoplasia of the macula (HP:0008059)	1.91978439
86	Abnormal mitochondria in muscle tissue (HP:0008316)	1.91321202
87	Febrile seizures (HP:0002373)	1.90646531
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.87547343
89	Optic disc pallor (HP:0000543)	1.87240080
90	Cystic liver disease (HP:0006706)	1.85997130
91	Hypoalbuminemia (HP:0003073)	1.85681857
92	Abnormal albumin level (HP:0012116)	1.85681857
93	Renal cortical cysts (HP:0000803)	1.85378393
94	Tachypnea (HP:0002789)	1.84917140
95	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.83895703
96	Inability to walk (HP:0002540)	1.83862327
97	Hypoplasia of the pons (HP:0012110)	1.83559697
98	Keratoconus (HP:0000563)	1.81589215
99	Increased corneal curvature (HP:0100692)	1.81589215
100	Tongue fasciculations (HP:0001308)	1.81383488

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.56522443
2	MST4	4.38787298
3	STK16	3.52208987
4	BMPR1B	3.19418803
5	FRK	3.03192582
6	TNIK	2.88831798
7	GRK1	2.79558941
8	TLK1	2.79317413
9	MAP3K12	2.39084151
10	ZAK	2.26303850
11	PASK	2.20841420
12	PHKG2	2.15032365
13	PHKG1	2.15032365
14	STK38L	2.09955423
15	WNK4	2.08900449
16	TAOK3	1.98036105
17	EIF2AK3	1.96064505
18	ACVR1B	1.95759195
19	ADRBK2	1.91575514
20	CASK	1.86761108
21	PINK1	1.62794573
22	STK24	1.59873123
23	STK3	1.49075243
24	MAP2K6	1.41267961
25	STK39	1.37272823
26	NTRK3	1.37103449
27	PTK2B	1.36936206
28	MAP3K13	1.34480991
29	RIPK4	1.21855844
30	OXSR1	1.21586534
31	PLK2	1.19906358
32	TEC	1.18713210
33	PRKCG	1.08128539
34	NUAK1	1.06083453
35	PRKAA2	1.03415659
36	INSRR	1.03406933
37	DAPK2	1.00328809
38	PRKCE	0.98308119
39	TGFBR2	0.89990616
40	TTK	0.85974297
41	NLK	0.81647496
42	FER	0.80036406
43	CDK3	0.79278706
44	MAP3K7	0.77487307
45	MKNK2	0.77369817
46	PLK3	0.75046052
47	BUB1	0.69591153
48	ADRBK1	0.69285490
49	PAK3	0.67660716
50	EIF2AK2	0.66431437
51	MELK	0.64874437
52	WNK3	0.63895705
53	BRSK2	0.62197228
54	GRK5	0.59577536
55	ERBB2	0.58907611
56	STK10	0.58789175
57	GRK7	0.55980961
58	CHUK	0.55710119
59	IKBKB	0.55384917
60	HIPK2	0.54500016
61	CSNK1D	0.52764063
62	PRKCA	0.52422459
63	TGFBR1	0.51988575
64	ITK	0.51614536
65	MYLK	0.51525831
66	IGF1R	0.51129341
67	MAPK13	0.49989528
68	BTK	0.49934181
69	PRKCI	0.49299064
70	PRKCQ	0.49042718
71	PRKG1	0.48879023
72	EIF2AK1	0.48702447
73	PLK4	0.48582693
74	CAMK2A	0.47885998
75	TXK	0.46604591
76	PLK1	0.43683536
77	AKT3	0.42855999
78	WNK1	0.40685752
79	STK11	0.40554813
80	PRKG2	0.39675512
81	LIMK1	0.38347965
82	CSNK1G1	0.37339232
83	OBSCN	0.36606394
84	SGK2	0.36068938
85	ATM	0.35841735
86	PRKAA1	0.34828156
87	MAP3K9	0.33593367
88	SRPK1	0.32860936
89	PRKACA	0.31982006
90	CSNK1G2	0.31750926
91	MAPKAPK3	0.31208847
92	STK4	0.31137061
93	PRKCH	0.29677551
94	CSNK1G3	0.29604396
95	PIM1	0.28475176
96	CAMK2D	0.28342938
97	VRK1	0.27143084
98	CAMKK2	0.27022886
99	CSNK2A1	0.25700042
100	CSNK1E	0.24309484

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.86229724
2	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.09553640
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.93057992
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.48872777
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.44097720
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.43248892
7	Regulation of autophagy_Homo sapiens_hsa04140	2.13598647
8	Basal transcription factors_Homo sapiens_hsa03022	2.03374499
9	Caffeine metabolism_Homo sapiens_hsa00232	2.01421322
10	One carbon pool by folate_Homo sapiens_hsa00670	2.01108513
11	Type I diabetes mellitus_Homo sapiens_hsa04940	1.98737577
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.81388293
13	Asthma_Homo sapiens_hsa05310	1.78149079
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.78074586
15	Sulfur metabolism_Homo sapiens_hsa00920	1.77864630
16	Insulin secretion_Homo sapiens_hsa04911	1.75397738
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.73520600
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.70911876
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.65572934
20	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.65143578
21	Phototransduction_Homo sapiens_hsa04744	1.60972396
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.58991736
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58366629
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.51537032
25	Homologous recombination_Homo sapiens_hsa03440	1.42390592
26	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.37639661
27	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29736015
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29038023
29	Allograft rejection_Homo sapiens_hsa05330	1.27525092
30	Circadian rhythm_Homo sapiens_hsa04710	1.26581902
31	Fat digestion and absorption_Homo sapiens_hsa04975	1.25146872
32	Protein export_Homo sapiens_hsa03060	1.23892953
33	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.22191486
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.21275567
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.20509164
36	RNA degradation_Homo sapiens_hsa03018	1.16289389
37	Salivary secretion_Homo sapiens_hsa04970	1.15342589
38	Pancreatic secretion_Homo sapiens_hsa04972	1.14051192
39	Proteasome_Homo sapiens_hsa03050	1.10745548
40	Olfactory transduction_Homo sapiens_hsa04740	1.09505561
41	Fatty acid elongation_Homo sapiens_hsa00062	1.08979282
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.04058179
43	Circadian entrainment_Homo sapiens_hsa04713	1.01392790
44	Long-term depression_Homo sapiens_hsa04730	0.98080089
45	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.97890632
46	Serotonergic synapse_Homo sapiens_hsa04726	0.95986927
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.95465360
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.93443077
49	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.91357143
50	Rheumatoid arthritis_Homo sapiens_hsa05323	0.88037659
51	Parkinsons disease_Homo sapiens_hsa05012	0.87298838
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.87132321
53	ABC transporters_Homo sapiens_hsa02010	0.84207186
54	Taste transduction_Homo sapiens_hsa04742	0.83723181
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83420401
56	Retinol metabolism_Homo sapiens_hsa00830	0.83046508
57	Alzheimers disease_Homo sapiens_hsa05010	0.79935702
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79056160
59	Morphine addiction_Homo sapiens_hsa05032	0.78463232
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.78425165
61	Huntingtons disease_Homo sapiens_hsa05016	0.77869869
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75954035
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.75661364
64	Mineral absorption_Homo sapiens_hsa04978	0.74776273
65	Peroxisome_Homo sapiens_hsa04146	0.74408826
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.72627157
67	Butanoate metabolism_Homo sapiens_hsa00650	0.72150503
68	Arginine biosynthesis_Homo sapiens_hsa00220	0.71474117
69	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.70502356
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.68426957
71	Nicotine addiction_Homo sapiens_hsa05033	0.65297574
72	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.60674571
73	GABAergic synapse_Homo sapiens_hsa04727	0.59476077
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58830921
75	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.58215448
76	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.54833811
77	Type II diabetes mellitus_Homo sapiens_hsa04930	0.51836208
78	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.50849769
79	Oocyte meiosis_Homo sapiens_hsa04114	0.48252685
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47491266
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46063299
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45991547
83	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.44306499
84	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43332821
85	Metabolic pathways_Homo sapiens_hsa01100	0.42574600
86	Purine metabolism_Homo sapiens_hsa00230	0.41410885
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.41395025
88	RNA transport_Homo sapiens_hsa03013	0.40449828
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39432670
90	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.37438280
91	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.37050631
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.34243573
93	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.33341279
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.32935862
95	Antigen processing and presentation_Homo sapiens_hsa04612	0.31401032
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.29464104
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.29429321
98	Bile secretion_Homo sapiens_hsa04976	0.27848593
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26918421
100	Gastric acid secretion_Homo sapiens_hsa04971	0.25380714

MTND2P31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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