ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adult feeding behavior (GO:0008343)	6.30478812
2	regulation of response to food (GO:0032095)	5.40842659
3	regulation of appetite (GO:0032098)	4.95712582
4	protein complex biogenesis (GO:0070271)	4.16598121
5	rRNA methylation (GO:0031167)	4.07104807
6	rRNA modification (GO:0000154)	4.06241599
7	mitochondrial respiratory chain complex assembly (GO:0033108)	4.00136330
8	histamine transport (GO:0051608)	3.99544222
9	response to pheromone (GO:0019236)	3.88675904
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.72166097
11	NADH dehydrogenase complex assembly (GO:0010257)	3.72166097
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.72166097
13	histamine secretion (GO:0001821)	3.71697384
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.66457888
15	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.64381777
16	GTP biosynthetic process (GO:0006183)	3.63064573
17	protein deneddylation (GO:0000338)	3.61928462
18	cellular ketone body metabolic process (GO:0046950)	3.61433714
19	exocrine pancreas development (GO:0031017)	3.48882574
20	chaperone-mediated protein transport (GO:0072321)	3.45690391
21	protein K11-linked deubiquitination (GO:0035871)	3.42180633
22	cullin deneddylation (GO:0010388)	3.36522982
23	aggressive behavior (GO:0002118)	3.34589917
24	negative regulation of response to food (GO:0032096)	3.31783880
25	negative regulation of appetite (GO:0032099)	3.31783880
26	gamma-aminobutyric acid transport (GO:0015812)	3.31716019
27	negative regulation of dendrite development (GO:2000171)	3.29814302
28	regulation of neurotransmitter uptake (GO:0051580)	3.27189157
29	protein polyglutamylation (GO:0018095)	3.25985333
30	ketone body metabolic process (GO:1902224)	3.25625042
31	estrogen biosynthetic process (GO:0006703)	3.17856557
32	nonmotile primary cilium assembly (GO:0035058)	3.17761100
33	glycosphingolipid biosynthetic process (GO:0006688)	3.17738750
34	inositol phosphate catabolic process (GO:0071545)	3.15525254
35	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.14321424
36	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.10882287
37	UTP biosynthetic process (GO:0006228)	3.09628956
38	cornea development in camera-type eye (GO:0061303)	3.08850394
39	epithelial cilium movement (GO:0003351)	3.03179895
40	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.00922551
41	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.99526671
42	negative regulation of heart rate (GO:0010459)	2.98193837
43	rhodopsin mediated signaling pathway (GO:0016056)	2.96501703
44	somite development (GO:0061053)	2.91723334
45	azole transport (GO:0045117)	2.90067011
46	regulation of protein kinase A signaling (GO:0010738)	2.87039393
47	regulation of telomere maintenance (GO:0032204)	2.86842884
48	UTP metabolic process (GO:0046051)	2.86175300
49	arginine catabolic process (GO:0006527)	2.85897961
50	positive regulation of response to extracellular stimulus (GO:0032106)	2.83685017
51	positive regulation of response to nutrient levels (GO:0032109)	2.83685017
52	negative regulation of telomere maintenance (GO:0032205)	2.82441583
53	response to dietary excess (GO:0002021)	2.81671288
54	eye photoreceptor cell differentiation (GO:0001754)	2.80645275
55	photoreceptor cell differentiation (GO:0046530)	2.80645275
56	positive regulation of meiosis (GO:0045836)	2.79237690
57	positive regulation of mitochondrial fission (GO:0090141)	2.78487304
58	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.78309189
59	regulation of chemokine biosynthetic process (GO:0045073)	2.77974832
60	retinal cone cell development (GO:0046549)	2.75043677
61	polyol catabolic process (GO:0046174)	2.74519412
62	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.74134373
63	inositol phosphate dephosphorylation (GO:0046855)	2.74134373
64	positive regulation of action potential (GO:0045760)	2.73037399
65	startle response (GO:0001964)	2.72417376
66	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.71986205
67	regulation of action potential (GO:0098900)	2.69636985
68	respiratory chain complex IV assembly (GO:0008535)	2.69472361
69	kidney morphogenesis (GO:0060993)	2.69361912
70	C4-dicarboxylate transport (GO:0015740)	2.68034082
71	piRNA metabolic process (GO:0034587)	2.67745336
72	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.66497093
73	cytochrome complex assembly (GO:0017004)	2.64995648
74	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.64593889
75	regulation of telomere maintenance via telomerase (GO:0032210)	2.63595372
76	axoneme assembly (GO:0035082)	2.63427835
77	neuronal action potential propagation (GO:0019227)	2.63362388
78	electron transport chain (GO:0022900)	2.60835613
79	positive regulation of meiotic cell cycle (GO:0051446)	2.60186978
80	respiratory electron transport chain (GO:0022904)	2.59705775
81	neuropeptide signaling pathway (GO:0007218)	2.59501056
82	mitochondrial calcium ion homeostasis (GO:0051560)	2.59076191
83	centriole replication (GO:0007099)	2.58207771
84	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.54099694
85	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.54099694
86	pseudouridine synthesis (GO:0001522)	2.53820579
87	ATP synthesis coupled proton transport (GO:0015986)	2.50315975
88	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.50315975
89	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.48886113
90	nitric oxide mediated signal transduction (GO:0007263)	2.48403350
91	preassembly of GPI anchor in ER membrane (GO:0016254)	2.48279568
92	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.47748309
93	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.46450273
94	fatty acid transmembrane transport (GO:1902001)	2.45447175
95	positive regulation of growth hormone secretion (GO:0060124)	2.44433622
96	negative regulation of dendrite morphogenesis (GO:0050774)	2.44260556
97	neuronal ion channel clustering (GO:0045161)	2.44226444
98	behavioral defense response (GO:0002209)	2.43301769
99	behavioral fear response (GO:0001662)	2.43301769
100	DNA double-strand break processing (GO:0000729)	2.42968216

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.44682559
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.15594942
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.96923289
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.92802195
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.87643442
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.86147459
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.43444800
8	VDR_22108803_ChIP-Seq_LS180_Human	2.40237115
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37925948
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.23394009
11	EWS_26573619_Chip-Seq_HEK293_Human	2.22486439
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.22127325
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20008338
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.18389474
15	P300_19829295_ChIP-Seq_ESCs_Human	2.15653344
16	FUS_26573619_Chip-Seq_HEK293_Human	2.10406669
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06092469
18	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.99990406
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.95667390
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.87233530
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.82397886
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.78991643
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76223403
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.75643443
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72414083
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.72350481
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.64633650
28	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.55504079
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53533373
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.53173268
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51678211
32	AR_25329375_ChIP-Seq_VCAP_Human	1.50026755
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47127313
34	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.46188004
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.44598290
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41239670
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39580838
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39457932
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.39347226
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.39220769
41	TCF4_22108803_ChIP-Seq_LS180_Human	1.39189741
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39133998
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38640661
44	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.38621253
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37744480
46	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.36741680
47	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36711753
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36310159
49	TCF4_23295773_ChIP-Seq_U87_Human	1.34685749
50	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.34536376
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.33877888
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32464986
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31718199
54	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30511505
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30139937
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30107505
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29404365
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.29069203
59	STAT3_23295773_ChIP-Seq_U87_Human	1.28417754
60	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.27360210
61	VDR_23849224_ChIP-Seq_CD4+_Human	1.25755226
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.25698884
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25565038
64	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.25345212
65	ELK1_19687146_ChIP-ChIP_HELA_Human	1.23811904
66	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.23234567
67	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23018090
68	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.22946795
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22557023
70	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21870414
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.21442894
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21442894
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.18728314
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.16810839
75	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16225933
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15988448
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15649261
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14278216
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13043134
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12571588
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12571588
82	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10397087
83	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.09225749
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08832486
85	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.08646748
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08643506
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08197004
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08191435
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06857464
90	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.05519507
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04644985
92	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04483204
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03635849
94	P300_18555785_Chip-Seq_ESCs_Mouse	1.03093207
95	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02772483
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01241994
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01078796
98	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01078796
99	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.00923982
100	JUN_21703547_ChIP-Seq_K562_Human	0.99753018

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.62642972
2	MP0002837_dystrophic_cardiac_calcinosis	3.70432082
3	MP0004145_abnormal_muscle_electrophysio	2.63181576
4	MP0001529_abnormal_vocalization	2.62824187
5	MP0005423_abnormal_somatic_nervous	2.51118726
6	MP0001501_abnormal_sleep_pattern	2.30568202
7	MP0006072_abnormal_retinal_apoptosis	2.18138240
8	MP0005174_abnormal_tail_pigmentation	2.17396533
9	MP0004270_analgesia	2.07582491
10	MP0000372_irregular_coat_pigmentation	2.03683171
11	MP0003186_abnormal_redox_activity	1.96683562
12	MP0005551_abnormal_eye_electrophysiolog	1.96672100
13	MP0004147_increased_porphyrin_level	1.90706192
14	MP0001986_abnormal_taste_sensitivity	1.84358266
15	MP0002938_white_spotting	1.82159305
16	MP0002736_abnormal_nociception_after	1.81197783
17	MP0003787_abnormal_imprinting	1.76967356
18	MP0005379_endocrine/exocrine_gland_phen	1.76780001
19	MP0003172_abnormal_lysosome_physiology	1.74446606
20	MP0008995_early_reproductive_senescence	1.73525925
21	MP0008877_abnormal_DNA_methylation	1.70219616
22	MP0002909_abnormal_adrenal_gland	1.68381392
23	MP0002876_abnormal_thyroid_physiology	1.67580658
24	MP0004084_abnormal_cardiac_muscle	1.64185374
25	MP0002272_abnormal_nervous_system	1.61352731
26	MP0003718_maternal_effect	1.61235114
27	MP0004885_abnormal_endolymph	1.56009965
28	MP0008775_abnormal_heart_ventricle	1.55242957
29	MP0006035_abnormal_mitochondrial_morpho	1.54212997
30	MP0001968_abnormal_touch/_nociception	1.53606635
31	MP0008789_abnormal_olfactory_epithelium	1.52162964
32	MP0003786_premature_aging	1.48982224
33	MP0005646_abnormal_pituitary_gland	1.47413259
34	MP0009745_abnormal_behavioral_response	1.47369512
35	MP0008058_abnormal_DNA_repair	1.47261944
36	MP0004924_abnormal_behavior	1.41565946
37	MP0005386_behavior/neurological_phenoty	1.41565946
38	MP0002734_abnormal_mechanical_nocicepti	1.40408465
39	MP0001440_abnormal_grooming_behavior	1.40022762
40	MP0005360_urolithiasis	1.37790242
41	MP0005253_abnormal_eye_physiology	1.35788922
42	MP0004859_abnormal_synaptic_plasticity	1.35177551
43	MP0001486_abnormal_startle_reflex	1.32921446
44	MP0002163_abnormal_gland_morphology	1.30754781
45	MP0002733_abnormal_thermal_nociception	1.27556443
46	MP0001970_abnormal_pain_threshold	1.24434798
47	MP0008872_abnormal_physiological_respon	1.23935639
48	MP0004133_heterotaxia	1.23714330
49	MP0005365_abnormal_bile_salt	1.23098091
50	MP0009046_muscle_twitch	1.21986915
51	MP0002064_seizures	1.20002671
52	MP0005075_abnormal_melanosome_morpholog	1.19101332
53	MP0003635_abnormal_synaptic_transmissio	1.16732428
54	MP0005645_abnormal_hypothalamus_physiol	1.13869188
55	MP0000427_abnormal_hair_cycle	1.12130760
56	MP0004484_altered_response_of	1.11682959
57	MP0001873_stomach_inflammation	1.11590191
58	MP0003646_muscle_fatigue	1.10230964
59	MP0005332_abnormal_amino_acid	1.08397765
60	MP0004043_abnormal_pH_regulation	1.05436130
61	MP0002234_abnormal_pharynx_morphology	1.05382116
62	MP0006036_abnormal_mitochondrial_physio	1.04822912
63	MP0000631_abnormal_neuroendocrine_gland	1.00419019
64	MP0010094_abnormal_chromosome_stability	1.00395027
65	MP0002229_neurodegeneration	0.99784558
66	MP0004215_abnormal_myocardial_fiber	0.97868300
67	MP0006292_abnormal_olfactory_placode	0.96806200
68	MP0002557_abnormal_social/conspecific_i	0.95789266
69	MP0002572_abnormal_emotion/affect_behav	0.95677599
70	MP0002063_abnormal_learning/memory/cond	0.95383031
71	MP0002735_abnormal_chemical_nociception	0.94957994
72	MP0001764_abnormal_homeostasis	0.93117541
73	MP0002160_abnormal_reproductive_system	0.91959620
74	MP0002693_abnormal_pancreas_physiology	0.90458938
75	MP0003122_maternal_imprinting	0.89471659
76	MP0000015_abnormal_ear_pigmentation	0.87569763
77	MP0005535_abnormal_body_temperature	0.86558942
78	MP0003950_abnormal_plasma_membrane	0.86429543
79	MP0003183_abnormal_peptide_metabolism	0.86232698
80	MP0004742_abnormal_vestibular_system	0.86170293
81	MP0001984_abnormal_olfaction	0.85596542
82	MP0008875_abnormal_xenobiotic_pharmacok	0.85291291
83	MP0003011_delayed_dark_adaptation	0.84535401
84	MP0001485_abnormal_pinna_reflex	0.84433808
85	MP0005408_hypopigmentation	0.83545571
86	MP0002095_abnormal_skin_pigmentation	0.83218090
87	MP0005499_abnormal_olfactory_system	0.82468596
88	MP0005394_taste/olfaction_phenotype	0.82468596
89	MP0005220_abnormal_exocrine_pancreas	0.82414994
90	MP0002067_abnormal_sensory_capabilities	0.80921253
91	MP0003633_abnormal_nervous_system	0.80818659
92	MP0004142_abnormal_muscle_tone	0.79724773
93	MP0001188_hyperpigmentation	0.79313980
94	MP0000358_abnormal_cell_content/	0.79147758
95	MP0010386_abnormal_urinary_bladder	0.78294290
96	MP0001293_anophthalmia	0.78152869
97	MP0009780_abnormal_chondrocyte_physiolo	0.77258236
98	MP0005636_abnormal_mineral_homeostasis	0.77191227
99	MP0006276_abnormal_autonomic_nervous	0.76376879
100	MP0005389_reproductive_system_phenotype	0.76252534

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.86544361
2	Absent/shortened dynein arms (HP:0200106)	3.86544361
3	Medial flaring of the eyebrow (HP:0010747)	3.64170245
4	Hemiparesis (HP:0001269)	3.60938914
5	Renal Fanconi syndrome (HP:0001994)	3.27392769
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.25739619
7	Nephronophthisis (HP:0000090)	3.24366201
8	Febrile seizures (HP:0002373)	3.17803219
9	Acute necrotizing encephalopathy (HP:0006965)	3.16642175
10	Lipid accumulation in hepatocytes (HP:0006561)	3.10194774
11	Pancreatic fibrosis (HP:0100732)	3.07130086
12	Increased hepatocellular lipid droplets (HP:0006565)	3.01685465
13	Tubular atrophy (HP:0000092)	3.01391973
14	Mitochondrial inheritance (HP:0001427)	2.96567239
15	Hyperventilation (HP:0002883)	2.94285590
16	Increased intramyocellular lipid droplets (HP:0012240)	2.89689627
17	Type II lissencephaly (HP:0007260)	2.89608413
18	Progressive macrocephaly (HP:0004481)	2.85215170
19	Acute encephalopathy (HP:0006846)	2.81024787
20	Increased CSF lactate (HP:0002490)	2.77718336
21	Abnormality of the renal medulla (HP:0100957)	2.73852657
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.69927897
23	Gaze-evoked nystagmus (HP:0000640)	2.69813837
24	Abnormality of the renal cortex (HP:0011035)	2.63325909
25	Gait imbalance (HP:0002141)	2.57429306
26	Hepatocellular necrosis (HP:0001404)	2.57340343
27	Exertional dyspnea (HP:0002875)	2.56501752
28	Increased muscle lipid content (HP:0009058)	2.55503553
29	Congenital primary aphakia (HP:0007707)	2.55278644
30	Abnormality of renal resorption (HP:0011038)	2.37452558
31	Focal motor seizures (HP:0011153)	2.36141694
32	Molar tooth sign on MRI (HP:0002419)	2.34644071
33	Abnormality of midbrain morphology (HP:0002418)	2.34644071
34	Abnormal ciliary motility (HP:0012262)	2.33411166
35	Broad-based gait (HP:0002136)	2.31112225
36	Optic nerve hypoplasia (HP:0000609)	2.31092658
37	Nephrogenic diabetes insipidus (HP:0009806)	2.29636283
38	Sensory axonal neuropathy (HP:0003390)	2.28026075
39	Tubulointerstitial nephritis (HP:0001970)	2.24504044
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.23920260
41	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.23086500
42	Abolished electroretinogram (ERG) (HP:0000550)	2.19941460
43	Thrombocytosis (HP:0001894)	2.19823779
44	Absent speech (HP:0001344)	2.15337420
45	Genital tract atresia (HP:0001827)	2.13360483
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.11800438
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.11800438
48	Abnormal drinking behavior (HP:0030082)	2.10838869
49	Polydipsia (HP:0001959)	2.10838869
50	Hypomagnesemia (HP:0002917)	2.08026318
51	Adrenal hypoplasia (HP:0000835)	2.07752180
52	Pancreatic cysts (HP:0001737)	2.06464482
53	Renal cortical cysts (HP:0000803)	2.06237088
54	True hermaphroditism (HP:0010459)	2.05544640
55	Tubulointerstitial abnormality (HP:0001969)	2.05524774
56	3-Methylglutaconic aciduria (HP:0003535)	2.05299736
57	Retinal dysplasia (HP:0007973)	2.03552518
58	Cerebral edema (HP:0002181)	2.03105314
59	Status epilepticus (HP:0002133)	2.00707645
60	Hypoplasia of the fovea (HP:0007750)	2.00671772
61	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.00671772
62	Increased serum lactate (HP:0002151)	2.00078721
63	Drooling (HP:0002307)	1.99905437
64	Enlarged kidneys (HP:0000105)	1.99374808
65	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.98342377
66	Disproportionate short-trunk short stature (HP:0003521)	1.97172820
67	Abnormal respiratory motile cilium physiology (HP:0012261)	1.96751961
68	Vaginal atresia (HP:0000148)	1.94612254
69	Attenuation of retinal blood vessels (HP:0007843)	1.92473036
70	Hypoproteinemia (HP:0003075)	1.91090040
71	Congenital stationary night blindness (HP:0007642)	1.91003556
72	Hip dysplasia (HP:0001385)	1.87325192
73	Poor coordination (HP:0002370)	1.87085977
74	Small hand (HP:0200055)	1.86706619
75	Astigmatism (HP:0000483)	1.84217453
76	Optic disc pallor (HP:0000543)	1.83422019
77	Excessive salivation (HP:0003781)	1.82774762
78	Failure to thrive in infancy (HP:0001531)	1.82474427
79	Parakeratosis (HP:0001036)	1.78898120
80	Chromsome breakage (HP:0040012)	1.78067554
81	Abnormality of magnesium homeostasis (HP:0004921)	1.76315784
82	Hepatic necrosis (HP:0002605)	1.75889480
83	Cheilitis (HP:0100825)	1.73918376
84	Tubulointerstitial fibrosis (HP:0005576)	1.71892797
85	Abnormal protein glycosylation (HP:0012346)	1.71823579
86	Abnormal glycosylation (HP:0012345)	1.71823579
87	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.71823579
88	Abnormal protein N-linked glycosylation (HP:0012347)	1.71823579
89	Lactic acidosis (HP:0003128)	1.68853432
90	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.67860446
91	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.67860446
92	Abnormality of lateral ventricle (HP:0030047)	1.67262510
93	Volvulus (HP:0002580)	1.66676588
94	Focal seizures (HP:0007359)	1.65193201
95	Dialeptic seizures (HP:0011146)	1.64829669
96	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.64577796
97	Absent eyebrow (HP:0002223)	1.64539334
98	Visual hallucinations (HP:0002367)	1.64089246
99	Hypoalbuminemia (HP:0003073)	1.63924212
100	Abnormal albumin level (HP:0012116)	1.63924212

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	8.64413273
2	SIK3	7.02512310
3	BCR	5.26463731
4	FRK	2.76441855
5	TAOK3	2.30781772
6	MUSK	2.14077273
7	ACVR1B	2.11917661
8	KSR1	2.06291559
9	WNK3	1.71612056
10	ERBB3	1.64196749
11	PAK3	1.58348011
12	TAF1	1.42135755
13	WNK4	1.39733842
14	BMPR1B	1.36980995
15	MAP4K2	1.35090363
16	GRK1	1.24424498
17	ADRBK2	1.12584359
18	MINK1	1.11605635
19	DAPK2	1.11424907
20	PLK2	1.10437344
21	MAP3K4	1.09755443
22	STK39	1.07457457
23	MAPK13	1.04868443
24	TXK	1.03879962
25	CSNK1G2	1.00428319
26	LIMK1	0.99875306
27	PAK6	0.98078029
28	MAP3K3	0.97584254
29	PINK1	0.89376154
30	TEC	0.87978723
31	BMPR2	0.82492491
32	MAP2K7	0.82135203
33	CASK	0.81500086
34	CSNK1G1	0.77809049
35	MARK1	0.75292385
36	CSNK1G3	0.75275624
37	PRKCE	0.74189532
38	PTK2B	0.71031554
39	CSNK1A1L	0.66707565
40	TESK2	0.65629788
41	MKNK2	0.65232277
42	DYRK2	0.62622691
43	BRD4	0.60903003
44	PRKCG	0.60752559
45	CDK18	0.53605171
46	TNK2	0.53155533
47	CDK19	0.50861448
48	FER	0.50560973
49	TESK1	0.50247197
50	NUAK1	0.50026520
51	INSRR	0.49536586
52	UHMK1	0.46466131
53	CCNB1	0.45695894
54	CSNK1A1	0.45440284
55	CAMK2A	0.45216442
56	PHKG2	0.41470380
57	PHKG1	0.41470380
58	OXSR1	0.40572709
59	KIT	0.39664826
60	OBSCN	0.38769871
61	MAP2K6	0.37578125
62	PRKACA	0.37055413
63	PRKACB	0.36763712
64	CSNK1E	0.36029026
65	DAPK1	0.35091153
66	PRKCI	0.32290744
67	TIE1	0.31704370
68	BRAF	0.31452029
69	BTK	0.31116672
70	SGK2	0.31040805
71	PRKCB	0.30825978
72	CAMK1	0.29874513
73	EIF2AK2	0.28284606
74	NME2	0.27440578
75	MST4	0.26985795
76	STK11	0.25736394
77	ARAF	0.25547502
78	CSNK1D	0.25466192
79	PRKCZ	0.24905899
80	IGF1R	0.24385343
81	PRKCQ	0.24158439
82	PRKCA	0.24152425
83	CDK14	0.24001725
84	PLK4	0.23565122
85	PRKG1	0.23413474
86	GRK7	0.23121657
87	CAMK2D	0.23114682
88	CDK5	0.22957231
89	SYK	0.21215804
90	TLK1	0.20851612
91	CAMKK2	0.19863403
92	PNCK	0.19256084
93	ERBB2	0.18915260
94	MAP2K1	0.18719941
95	CSNK2A1	0.18653157
96	TRPM7	0.18238137
97	RPS6KA3	0.18129591
98	DYRK1A	0.18021195
99	ZAK	0.17263748
100	PRKACG	0.16672935

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.25470919
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.23902767
3	Protein export_Homo sapiens_hsa03060	3.02878842
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.56092487
5	Parkinsons disease_Homo sapiens_hsa05012	2.55042111
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18842278
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.90162265
8	Alzheimers disease_Homo sapiens_hsa05010	1.87115107
9	Nicotine addiction_Homo sapiens_hsa05033	1.80740169
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.76449560
11	Butanoate metabolism_Homo sapiens_hsa00650	1.73654090
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72929923
13	Basal transcription factors_Homo sapiens_hsa03022	1.72018141
14	Proteasome_Homo sapiens_hsa03050	1.70882710
15	RNA polymerase_Homo sapiens_hsa03020	1.69361339
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.64099862
17	Olfactory transduction_Homo sapiens_hsa04740	1.63905436
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.62185726
19	Huntingtons disease_Homo sapiens_hsa05016	1.60837811
20	Collecting duct acid secretion_Homo sapiens_hsa04966	1.59530384
21	Asthma_Homo sapiens_hsa05310	1.59366125
22	GABAergic synapse_Homo sapiens_hsa04727	1.55548828
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.50616875
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.50061684
25	Regulation of autophagy_Homo sapiens_hsa04140	1.47176022
26	Circadian entrainment_Homo sapiens_hsa04713	1.44188029
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.34962783
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.34233158
29	Morphine addiction_Homo sapiens_hsa05032	1.33126060
30	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.32465176
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.32463009
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26138004
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22089744
34	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.21877330
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.19310982
36	Dopaminergic synapse_Homo sapiens_hsa04728	1.16320000
37	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.13892211
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.09985314
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09043830
40	Insulin secretion_Homo sapiens_hsa04911	1.09036754
41	Glutamatergic synapse_Homo sapiens_hsa04724	1.08111960
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08107598
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.04519772
44	Taste transduction_Homo sapiens_hsa04742	1.03441149
45	Steroid biosynthesis_Homo sapiens_hsa00100	1.02639376
46	Retinol metabolism_Homo sapiens_hsa00830	1.01964348
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00858458
48	Sulfur metabolism_Homo sapiens_hsa00920	1.00002789
49	Homologous recombination_Homo sapiens_hsa03440	0.99554047
50	Peroxisome_Homo sapiens_hsa04146	0.98608712
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.98584151
52	Long-term depression_Homo sapiens_hsa04730	0.97533344
53	Renin-angiotensin system_Homo sapiens_hsa04614	0.96151105
54	Amphetamine addiction_Homo sapiens_hsa05031	0.94071788
55	Serotonergic synapse_Homo sapiens_hsa04726	0.93148969
56	RNA degradation_Homo sapiens_hsa03018	0.92842419
57	Oocyte meiosis_Homo sapiens_hsa04114	0.87074264
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.86200349
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.85209932
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.82763792
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.81988703
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.81008308
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79731510
64	Allograft rejection_Homo sapiens_hsa05330	0.77858189
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.76705893
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76318798
67	Salivary secretion_Homo sapiens_hsa04970	0.73381787
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72022351
69	Renin secretion_Homo sapiens_hsa04924	0.71782884
70	Circadian rhythm_Homo sapiens_hsa04710	0.69945860
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.69598876
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67980762
73	Cocaine addiction_Homo sapiens_hsa05030	0.66974478
74	Metabolic pathways_Homo sapiens_hsa01100	0.66570807
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66133262
76	Vibrio cholerae infection_Homo sapiens_hsa05110	0.64113671
77	Purine metabolism_Homo sapiens_hsa00230	0.63667486
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62935950
79	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.61281656
80	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60625326
81	Fatty acid elongation_Homo sapiens_hsa00062	0.59268691
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.58898977
83	Propanoate metabolism_Homo sapiens_hsa00640	0.58519696
84	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.57301897
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56630170
86	Glutathione metabolism_Homo sapiens_hsa00480	0.55830888
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53724866
88	Mineral absorption_Homo sapiens_hsa04978	0.52490532
89	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51123631
90	Caffeine metabolism_Homo sapiens_hsa00232	0.47605684
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46769983
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.45202717
93	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.44507783
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.44128420
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43825862
96	ABC transporters_Homo sapiens_hsa02010	0.42342965
97	Gastric acid secretion_Homo sapiens_hsa04971	0.41649732
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.40028669
99	Long-term potentiation_Homo sapiens_hsa04720	0.38573354
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.34139999

MTND2P32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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