ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.72249237
2	L-phenylalanine catabolic process (GO:0006559)	5.72249237
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.09965609
4	L-phenylalanine metabolic process (GO:0006558)	5.09965609
5	phenylpropanoid metabolic process (GO:0009698)	5.04471476
6	glyoxylate metabolic process (GO:0046487)	4.99273321
7	serine family amino acid catabolic process (GO:0009071)	4.80827719
8	cellular ketone body metabolic process (GO:0046950)	4.40092568
9	regulation of triglyceride catabolic process (GO:0010896)	4.25293764
10	aromatic amino acid family catabolic process (GO:0009074)	4.01946432
11	regulation of fibrinolysis (GO:0051917)	3.95727079
12	ketone body metabolic process (GO:1902224)	3.80183501
13	blood coagulation, intrinsic pathway (GO:0007597)	3.79913363
14	drug catabolic process (GO:0042737)	3.62167062
15	oxidative demethylation (GO:0070989)	3.62110589
16	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.56984075
17	synapsis (GO:0007129)	3.44522570
18	tyrosine metabolic process (GO:0006570)	3.43351008
19	daunorubicin metabolic process (GO:0044597)	3.42830557
20	polyketide metabolic process (GO:0030638)	3.42830557
21	doxorubicin metabolic process (GO:0044598)	3.42830557
22	sulfur amino acid catabolic process (GO:0000098)	3.40492409
23	acylglycerol homeostasis (GO:0055090)	3.38453128
24	triglyceride homeostasis (GO:0070328)	3.38453128
25	cellular glucuronidation (GO:0052695)	3.38011797
26	neural tube formation (GO:0001841)	3.35398897
27	cysteine metabolic process (GO:0006534)	3.30674944
28	detection of temperature stimulus (GO:0016048)	3.29126960
29	glucuronate metabolic process (GO:0019585)	3.29033165
30	uronic acid metabolic process (GO:0006063)	3.29033165
31	negative regulation of acute inflammatory response (GO:0002674)	3.28622289
32	xenobiotic catabolic process (GO:0042178)	3.26979191
33	positive regulation of granulocyte differentiation (GO:0030854)	3.26968079
34	aminoglycoside antibiotic metabolic process (GO:0030647)	3.22656736
35	nucleobase catabolic process (GO:0046113)	3.18394916
36	regulation of immunoglobulin secretion (GO:0051023)	3.18180218
37	protein carboxylation (GO:0018214)	3.16431489
38	peptidyl-glutamic acid carboxylation (GO:0017187)	3.16431489
39	positive regulation of coagulation (GO:0050820)	3.14719781
40	glycine metabolic process (GO:0006544)	3.13035989
41	positive regulation of blood coagulation (GO:0030194)	3.12455900
42	positive regulation of hemostasis (GO:1900048)	3.12455900
43	bile acid and bile salt transport (GO:0015721)	3.06206545
44	glycerophospholipid catabolic process (GO:0046475)	3.04795154
45	protein neddylation (GO:0045116)	2.95227064
46	sulfation (GO:0051923)	2.89263536
47	cellular biogenic amine catabolic process (GO:0042402)	2.83618175
48	amine catabolic process (GO:0009310)	2.83618175
49	drug transmembrane transport (GO:0006855)	2.83321367
50	urea metabolic process (GO:0019627)	2.82405044
51	serine family amino acid metabolic process (GO:0009069)	2.81889862
52	L-ascorbic acid metabolic process (GO:0019852)	2.81232919
53	thyroid hormone metabolic process (GO:0042403)	2.80921893
54	artery smooth muscle contraction (GO:0014824)	2.80353543
55	thyroid hormone generation (GO:0006590)	2.79537870
56	adenosine metabolic process (GO:0046085)	2.78596812
57	arginine metabolic process (GO:0006525)	2.78462237
58	negative regulation of complement activation (GO:0045916)	2.76771541
59	regulation of podosome assembly (GO:0071801)	2.74224523
60	regulation of sequestering of triglyceride (GO:0010889)	2.73265562
61	cofactor catabolic process (GO:0051187)	2.70941947
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.69166120
63	bile acid biosynthetic process (GO:0006699)	2.66579339
64	regulation of protein activation cascade (GO:2000257)	2.63038953
65	protein insertion into membrane (GO:0051205)	2.62738347
66	negative regulation of lipid catabolic process (GO:0050995)	2.62503404
67	regulation of gonadotropin secretion (GO:0032276)	2.62266734
68	negative regulation of fibrinolysis (GO:0051918)	2.61823950
69	drug metabolic process (GO:0017144)	2.59568816
70	aromatic amino acid family metabolic process (GO:0009072)	2.59494971
71	nitrogen cycle metabolic process (GO:0071941)	2.58377447
72	urea cycle (GO:0000050)	2.58137220
73	maturation of 5.8S rRNA (GO:0000460)	2.56898047
74	mannosylation (GO:0097502)	2.56356018
75	peptidyl-glutamic acid modification (GO:0018200)	2.54466200
76	coenzyme catabolic process (GO:0009109)	2.54443837
77	fibrinolysis (GO:0042730)	2.52428642
78	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.52088419
79	isotype switching (GO:0045190)	2.52088419
80	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.52088419
81	tonic smooth muscle contraction (GO:0014820)	2.51767513
82	negative regulation of T-helper cell differentiation (GO:0045623)	2.51710952
83	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.51710952
84	epoxygenase P450 pathway (GO:0019373)	2.51582536
85	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.50566720
86	indole-containing compound catabolic process (GO:0042436)	2.50566161
87	indolalkylamine catabolic process (GO:0046218)	2.50566161
88	tryptophan catabolic process (GO:0006569)	2.50566161
89	regulation of lipoprotein metabolic process (GO:0050746)	2.50049107
90	bile acid metabolic process (GO:0008206)	2.49112024
91	secondary metabolic process (GO:0019748)	2.48461986
92	positive regulation of isotype switching (GO:0045830)	2.48182114
93	alkaloid metabolic process (GO:0009820)	2.48145626
94	regulation of RIG-I signaling pathway (GO:0039535)	2.46013254
95	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.45403728
96	steroid catabolic process (GO:0006706)	2.45161243
97	dopamine biosynthetic process (GO:0042416)	2.44904389
98	positive regulation of mast cell activation (GO:0033005)	2.44854452
99	T-helper cell differentiation (GO:0042093)	2.44230780
100	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.44230780

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.03026213
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.52790247
3	VDR_22108803_ChIP-Seq_LS180_Human	2.88932986
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.56451048
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.40907294
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.23070955
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.19301323
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.17813827
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.12437605
10	GATA3_21878914_ChIP-Seq_MCF-7_Human	2.01380724
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90570400
12	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.78902637
13	HTT_18923047_ChIP-ChIP_STHdh_Human	1.77082757
14	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.74159580
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.71001590
16	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.67425403
17	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.65737368
18	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.65282354
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.65082850
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62948338
21	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.60212507
22	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.59154385
23	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.59154385
24	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.57958258
25	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.57698015
26	AR_20517297_ChIP-Seq_VCAP_Human	1.55533307
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.53941707
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53820616
29	FUS_26573619_Chip-Seq_HEK293_Human	1.50271951
30	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.49360108
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.49200705
32	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.48654238
33	EWS_26573619_Chip-Seq_HEK293_Human	1.45887065
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.44511570
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.43560362
36	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.42771925
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42690636
38	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.42194524
39	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.40909618
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.40481834
41	STAT1_20625510_ChIP-Seq_HELA_Human	1.39922372
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.36690585
43	ZNF274_21170338_ChIP-Seq_K562_Hela	1.35680425
44	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.33442370
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32476292
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.30504005
47	GATA1_22025678_ChIP-Seq_K562_Human	1.29044415
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27454047
49	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.26751975
50	GATA3_26560356_Chip-Seq_TH2_Human	1.25212930
51	P300_19829295_ChIP-Seq_ESCs_Human	1.24788147
52	NCOR_22424771_ChIP-Seq_293T_Human	1.24756076
53	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.24718036
54	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.24610496
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24173513
56	PHF8_20622853_ChIP-Seq_HELA_Human	1.24115792
57	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23134949
58	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.21394472
59	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20397200
60	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.19573040
61	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.19488152
62	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.19488152
63	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.19488152
64	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18420947
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17756876
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17652769
67	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.16872068
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16569822
69	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.15931018
70	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15445030
71	NFYB_21822215_ChIP-Seq_K562_Human	1.14845676
72	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.14502614
73	STAT3_23295773_ChIP-Seq_U87_Human	1.13861473
74	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.13435307
75	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.12958050
76	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.12391237
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.12236923
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11909456
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11909456
80	CDX2_22108803_ChIP-Seq_LS180_Human	1.11745322
81	TAF15_26573619_Chip-Seq_HEK293_Human	1.11473989
82	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10352365
83	GATA3_26560356_Chip-Seq_TH1_Human	1.09933087
84	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09086621
85	VDR_23849224_ChIP-Seq_CD4+_Human	1.08705323
86	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.08513351
87	MYC_19829295_ChIP-Seq_ESCs_Human	1.07711743
88	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.07627966
89	CBP_21632823_ChIP-Seq_H3396_Human	1.07359527
90	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.07131239
91	RBPJ_21746931_ChIP-Seq_IB4_Human	1.07128619
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07115906
93	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.06659423
94	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05268418
95	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04901001
96	ERG_20517297_ChIP-Seq_VCAP_Human	1.04542866
97	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04358187
98	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03777212
99	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03573393
100	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.03153369

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	4.86782421
2	MP0000566_synostosis	4.69374439
3	MP0002138_abnormal_hepatobiliary_system	4.42449981
4	MP0008875_abnormal_xenobiotic_pharmacok	3.63715111
5	MP0000372_irregular_coat_pigmentation	3.63436180
6	MP0005360_urolithiasis	3.39185277
7	MP0005085_abnormal_gallbladder_physiolo	3.35019128
8	MP0009697_abnormal_copulation	3.07949893
9	MP0005171_absent_coat_pigmentation	2.98194312
10	MP0003195_calcinosis	2.78871651
11	MP0002876_abnormal_thyroid_physiology	2.75867165
12	MP0005365_abnormal_bile_salt	2.69078009
13	MP0001835_abnormal_antigen_presentation	2.49195121
14	MP0002938_white_spotting	2.29004412
15	MP0003136_yellow_coat_color	2.26401415
16	MP0003868_abnormal_feces_composition	2.17885766
17	MP0005187_abnormal_penis_morphology	2.17152990
18	MP0005167_abnormal_blood-brain_barrier	1.97842096
19	MP0001764_abnormal_homeostasis	1.84715244
20	MP0002837_dystrophic_cardiac_calcinosis	1.82689761
21	MP0003252_abnormal_bile_duct	1.81325369
22	MP0005645_abnormal_hypothalamus_physiol	1.80528606
23	MP0005464_abnormal_platelet_physiology	1.78660040
24	MP0003806_abnormal_nucleotide_metabolis	1.72679319
25	MP0010386_abnormal_urinary_bladder	1.67746623
26	MP0002638_abnormal_pupillary_reflex	1.65907052
27	MP0005408_hypopigmentation	1.65156380
28	MP0004019_abnormal_vitamin_homeostasis	1.64205340
29	MP0005410_abnormal_fertilization	1.63295351
30	MP0010329_abnormal_lipoprotein_level	1.58741643
31	MP0003186_abnormal_redox_activity	1.53761003
32	MP0002163_abnormal_gland_morphology	1.42354268
33	MP0009780_abnormal_chondrocyte_physiolo	1.40475478
34	MP0005332_abnormal_amino_acid	1.35268558
35	MP0005075_abnormal_melanosome_morpholog	1.34124015
36	MP0002928_abnormal_bile_duct	1.33502198
37	MP0003638_abnormal_response/metabolism_	1.30259658
38	MP0001986_abnormal_taste_sensitivity	1.29506036
39	MP0006072_abnormal_retinal_apoptosis	1.23886520
40	MP0005551_abnormal_eye_electrophysiolog	1.17559109
41	MP0006035_abnormal_mitochondrial_morpho	1.17518789
42	MP0005379_endocrine/exocrine_gland_phen	1.15970838
43	MP0001348_abnormal_lacrimal_gland	1.09080855
44	MP0005083_abnormal_biliary_tract	1.06979275
45	MP0004381_abnormal_hair_follicle	1.06746901
46	MP0006082_CNS_inflammation	1.06144929
47	MP0002102_abnormal_ear_morphology	1.04689832
48	MP0001984_abnormal_olfaction	1.02159861
49	MP0008872_abnormal_physiological_respon	1.01971600
50	MP0001919_abnormal_reproductive_system	1.00621148
51	MP0006036_abnormal_mitochondrial_physio	0.99975257
52	MP0004742_abnormal_vestibular_system	0.99418683
53	MP0005646_abnormal_pituitary_gland	0.99295725
54	MP0000647_abnormal_sebaceous_gland	0.94546576
55	MP0005253_abnormal_eye_physiology	0.94498312
56	MP0000631_abnormal_neuroendocrine_gland	0.91652056
57	MP0001968_abnormal_touch/_nociception	0.90652523
58	MP0003724_increased_susceptibility_to	0.89977059
59	MP0004133_heterotaxia	0.89163166
60	MP0005535_abnormal_body_temperature	0.88240664
61	MP0002822_catalepsy	0.87369031
62	MP0003879_abnormal_hair_cell	0.87283180
63	MP0002148_abnormal_hypersensitivity_rea	0.84227945
64	MP0002090_abnormal_vision	0.83908755
65	MP0005174_abnormal_tail_pigmentation	0.81057148
66	MP0005376_homeostasis/metabolism_phenot	0.80713441
67	MP0002132_abnormal_respiratory_system	0.80692699
68	MP0005584_abnormal_enzyme/coenzyme_acti	0.80416141
69	MP0005164_abnormal_response_to	0.79748907
70	MP0000015_abnormal_ear_pigmentation	0.77776605
71	MP0002118_abnormal_lipid_homeostasis	0.77685578
72	MP0002693_abnormal_pancreas_physiology	0.77596646
73	MP0005636_abnormal_mineral_homeostasis	0.76935875
74	MP0009642_abnormal_blood_homeostasis	0.76895883
75	MP0010234_abnormal_vibrissa_follicle	0.76689155
76	MP0004885_abnormal_endolymph	0.75507710
77	MP0006054_spinal_hemorrhage	0.75341924
78	MP0003172_abnormal_lysosome_physiology	0.74109993
79	MP0003878_abnormal_ear_physiology	0.72255574
80	MP0005377_hearing/vestibular/ear_phenot	0.72255574
81	MP0003880_abnormal_central_pattern	0.71985001
82	MP0002006_tumorigenesis	0.70567660
83	MP0001440_abnormal_grooming_behavior	0.69978345
84	MP0002166_altered_tumor_susceptibility	0.68729321
85	MP0003315_abnormal_perineum_morphology	0.67541589
86	MP0006276_abnormal_autonomic_nervous	0.66808224
87	MP0003959_abnormal_lean_body	0.66737083
88	MP0003718_maternal_effect	0.66644631
89	MP0000609_abnormal_liver_physiology	0.66642538
90	MP0003828_pulmonary_edema	0.65833316
91	MP0005084_abnormal_gallbladder_morpholo	0.65436252
92	MP0001765_abnormal_ion_homeostasis	0.65247930
93	MP0001666_abnormal_nutrient_absorption	0.64172525
94	MP0001661_extended_life_span	0.61553250
95	MP0004215_abnormal_myocardial_fiber	0.61217666
96	MP0009643_abnormal_urine_homeostasis	0.60812383
97	MP0003011_delayed_dark_adaptation	0.60242525
98	MP0005319_abnormal_enzyme/_coenzyme	0.59092838
99	MP0008469_abnormal_protein_level	0.58917200
100	MP0005389_reproductive_system_phenotype	0.58674936

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	5.76444632
2	Abnormal biliary tract physiology (HP:0012439)	4.24047195
3	Bile duct proliferation (HP:0001408)	4.24047195
4	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.91500056
5	Deep venous thrombosis (HP:0002625)	3.56981427
6	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.50731158
7	Asplenia (HP:0001746)	3.46834941
8	Abnormality of the renal cortex (HP:0011035)	3.41999376
9	Generalized aminoaciduria (HP:0002909)	3.40998691
10	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.32181276
11	Decreased central vision (HP:0007663)	3.26755672
12	Abnormal drinking behavior (HP:0030082)	3.18677113
13	Polydipsia (HP:0001959)	3.18677113
14	Chronic hepatic failure (HP:0100626)	3.17606600
15	Prolonged partial thromboplastin time (HP:0003645)	3.15265719
16	Hyperlipoproteinemia (HP:0010980)	3.11414636
17	Congenital sensorineural hearing impairment (HP:0008527)	3.05565504
18	Abnormality of pyrimidine metabolism (HP:0004353)	3.04722259
19	Spontaneous abortion (HP:0005268)	2.95458538
20	Reduced antithrombin III activity (HP:0001976)	2.90188286
21	Renal cortical cysts (HP:0000803)	2.89526052
22	Arthropathy (HP:0003040)	2.89420671
23	Abnormal pupillary function (HP:0007686)	2.87171578
24	Menorrhagia (HP:0000132)	2.82244590
25	Joint hemorrhage (HP:0005261)	2.78029881
26	Azoospermia (HP:0000027)	2.76428215
27	Large for gestational age (HP:0001520)	2.73225709
28	Small epiphyses (HP:0010585)	2.59363642
29	Proximal tubulopathy (HP:0000114)	2.59191851
30	Hypobetalipoproteinemia (HP:0003563)	2.58957343
31	Prolonged bleeding time (HP:0003010)	2.56755794
32	Tinnitus (HP:0000360)	2.56355449
33	Paralysis (HP:0003470)	2.55352645
34	Adrenal hypoplasia (HP:0000835)	2.53510467
35	3-Methylglutaconic aciduria (HP:0003535)	2.51842050
36	Gingival bleeding (HP:0000225)	2.50351658
37	Pancreatic fibrosis (HP:0100732)	2.49950704
38	Glycosuria (HP:0003076)	2.46650818
39	Abnormality of urine glucose concentration (HP:0011016)	2.46650818
40	Episodic fever (HP:0001954)	2.44789379
41	Abdominal situs inversus (HP:0003363)	2.38016529
42	Abnormality of abdominal situs (HP:0011620)	2.38016529
43	Volvulus (HP:0002580)	2.32776756
44	Abnormal spermatogenesis (HP:0008669)	2.32510617
45	Pancreatic cysts (HP:0001737)	2.26522147
46	Polyuria (HP:0000103)	2.21522835
47	Abnormal urine output (HP:0012590)	2.20571024
48	Patchy hypopigmentation of hair (HP:0011365)	2.18105040
49	Hyperglycemia (HP:0003074)	2.12325599
50	Nausea (HP:0002018)	2.09208333
51	True hermaphroditism (HP:0010459)	2.08576742
52	Supernumerary spleens (HP:0009799)	2.04948937
53	Gaze-evoked nystagmus (HP:0000640)	2.04541371
54	Molar tooth sign on MRI (HP:0002419)	2.01722637
55	Abnormality of midbrain morphology (HP:0002418)	2.01722637
56	Type II lissencephaly (HP:0007260)	2.00726654
57	Ketoacidosis (HP:0001993)	2.00089055
58	Abnormal hemoglobin (HP:0011902)	1.99829578
59	Abnormal rod and cone electroretinograms (HP:0008323)	1.99723485
60	Radial bowing (HP:0002986)	1.97580550
61	Dyskinesia (HP:0100660)	1.96438925
62	Acute encephalopathy (HP:0006846)	1.96128276
63	Tented upper lip vermilion (HP:0010804)	1.95326111
64	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.94850165
65	Insulin-resistant diabetes mellitus (HP:0000831)	1.94096965
66	Tubular atrophy (HP:0000092)	1.92042703
67	Abnormality of the renal medulla (HP:0100957)	1.90258317
68	Congenital stationary night blindness (HP:0007642)	1.88905003
69	Increased cerebral lipofuscin (HP:0011813)	1.88701932
70	Renal Fanconi syndrome (HP:0001994)	1.87760808
71	Hyperammonemia (HP:0001987)	1.85460686
72	Increased CSF protein (HP:0002922)	1.84033572
73	Nephronophthisis (HP:0000090)	1.82722865
74	Abnormality of renal excretion (HP:0011036)	1.82434983
75	Intrahepatic cholestasis (HP:0001406)	1.81695877
76	Thyroid-stimulating hormone excess (HP:0002925)	1.80483087
77	Anhidrosis (HP:0000970)	1.78489940
78	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.78117498
79	Delayed CNS myelination (HP:0002188)	1.77796122
80	Irritability (HP:0000737)	1.77657484
81	Exertional dyspnea (HP:0002875)	1.77328704
82	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.77055809
83	Abnormality of alanine metabolism (HP:0010916)	1.76942883
84	Hyperalaninemia (HP:0003348)	1.76942883
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76942883
86	Limited elbow extension (HP:0001377)	1.76926901
87	Lethargy (HP:0001254)	1.76912140
88	Aplasia of the musculature (HP:0100854)	1.75987600
89	Acute hepatic failure (HP:0006554)	1.75544952
90	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.75168549
91	Cone-rod dystrophy (HP:0000548)	1.74669876
92	Abnormality of nucleobase metabolism (HP:0010932)	1.73716770
93	Epistaxis (HP:0000421)	1.73233114
94	Abnormality of the common coagulation pathway (HP:0010990)	1.72513181
95	Sensorimotor neuropathy (HP:0007141)	1.72331392
96	Elevated erythrocyte sedimentation rate (HP:0003565)	1.70663527
97	Hemiparesis (HP:0001269)	1.69570797
98	Increased hepatocellular lipid droplets (HP:0006565)	1.69259302
99	Lipid accumulation in hepatocytes (HP:0006561)	1.68502587
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68208791

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	4.76962212
2	EPHB1	4.45339319
3	FRK	3.51455945
4	MAP3K13	3.28153124
5	EPHA3	2.81913930
6	WNK4	2.71149384
7	MST1R	2.64861899
8	BMPR2	2.63491277
9	FER	2.33591357
10	PIK3CG	2.31821388
11	PASK	2.17257693
12	STK39	2.05390690
13	DAPK2	1.85486653
14	STK16	1.80243798
15	FGFR3	1.72325410
16	EIF2AK1	1.72062113
17	PNCK	1.66057741
18	MAP3K14	1.66012238
19	TRPM7	1.58047552
20	ADRBK2	1.38588820
21	IRAK1	1.36475467
22	FES	1.31652588
23	TEC	1.28479386
24	CSNK1G3	1.26987037
25	PRKD3	1.22720672
26	PINK1	1.21768507
27	TNK2	1.19547769
28	IKBKB	1.19350863
29	MET	1.17263028
30	NLK	1.17062709
31	CSNK1A1L	1.11231517
32	CSNK1G1	1.10363606
33	TAOK3	1.09319894
34	PLK2	1.07830187
35	MAP3K9	1.06785647
36	CSNK1G2	1.05294610
37	EIF2AK3	1.04914924
38	MUSK	0.98491159
39	AKT3	0.98396671
40	IRAK3	0.98338282
41	MATK	0.94359837
42	BTK	0.93935795
43	STK3	0.92276153
44	MAP3K7	0.91220687
45	PHKG2	0.90305027
46	PHKG1	0.90305027
47	PTK2B	0.89903541
48	STK4	0.88157339
49	TSSK6	0.87619417
50	GRK6	0.86169040
51	IKBKE	0.84698806
52	MAP2K6	0.83818456
53	PAK3	0.83072478
54	MARK3	0.82440251
55	RIPK4	0.80504969
56	MAP2K3	0.79752523
57	MOS	0.77569184
58	MAP3K3	0.77499325
59	GRK1	0.76372103
60	TXK	0.69390808
61	EPHA4	0.67039958
62	BMPR1B	0.63921236
63	MAP3K12	0.63058009
64	ITK	0.60371688
65	PRKCE	0.59467784
66	TLK1	0.58681422
67	SYK	0.56475691
68	OXSR1	0.53343792
69	DYRK3	0.50528903
70	PRKCQ	0.49804882
71	IRAK4	0.48826467
72	JAK3	0.48652077
73	CHUK	0.47766428
74	IGF1R	0.44850659
75	CAMK2D	0.43267130
76	ACVR1B	0.43259866
77	LYN	0.43092519
78	PRKG1	0.42169715
79	PBK	0.41095114
80	NUAK1	0.40840411
81	FGFR1	0.39636131
82	BMX	0.38387359
83	FGFR4	0.37803185
84	CSK	0.37126076
85	NTRK2	0.36858436
86	CSF1R	0.35516784
87	TYK2	0.35454176
88	SIK3	0.35001657
89	PRKCI	0.34750043
90	MAP3K1	0.34528063
91	ZAP70	0.33080908
92	TYRO3	0.31130385
93	PDK1	0.30669210
94	PRKCG	0.30666428
95	CAMK1G	0.29862710
96	CDK3	0.29710270
97	GSK3A	0.29293345
98	INSRR	0.26810466
99	IRAK2	0.26554805
100	DYRK2	0.25845876

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.03534387
2	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.94217846
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.91424700
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.88718141
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.71428486
6	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.62485453
7	Retinol metabolism_Homo sapiens_hsa00830	2.55948235
8	Sulfur metabolism_Homo sapiens_hsa00920	2.42924009
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.40413357
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.36847095
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.27724666
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.19591546
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.14741967
14	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.01473511
15	Folate biosynthesis_Homo sapiens_hsa00790	2.01373713
16	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.99425907
17	Complement and coagulation cascades_Homo sapiens_hsa04610	1.91782356
18	Butanoate metabolism_Homo sapiens_hsa00650	1.90013480
19	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.88421385
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.87223239
21	Arginine biosynthesis_Homo sapiens_hsa00220	1.83750800
22	Peroxisome_Homo sapiens_hsa04146	1.83087512
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70349881
24	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.62769247
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.58724477
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55992361
27	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.51548328
28	Bile secretion_Homo sapiens_hsa04976	1.50400260
29	Caffeine metabolism_Homo sapiens_hsa00232	1.47243168
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.46213195
31	Phototransduction_Homo sapiens_hsa04744	1.45370340
32	Asthma_Homo sapiens_hsa05310	1.37376183
33	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.35555414
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35180558
35	Sulfur relay system_Homo sapiens_hsa04122	1.25044441
36	Allograft rejection_Homo sapiens_hsa05330	1.24509420
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.21085547
38	Phenylalanine metabolism_Homo sapiens_hsa00360	1.20754444
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.18290963
40	One carbon pool by folate_Homo sapiens_hsa00670	1.15802932
41	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.10902659
42	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.08047035
43	Mineral absorption_Homo sapiens_hsa04978	1.06598017
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.05626136
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04524700
46	Protein export_Homo sapiens_hsa03060	0.99387799
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.97442868
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.95790809
49	Fatty acid elongation_Homo sapiens_hsa00062	0.92888466
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91953222
51	Circadian rhythm_Homo sapiens_hsa04710	0.88051061
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87402901
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.85932880
54	Oxidative phosphorylation_Homo sapiens_hsa00190	0.84950366
55	Glutathione metabolism_Homo sapiens_hsa00480	0.84457492
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.83652176
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.80480128
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76228496
59	Propanoate metabolism_Homo sapiens_hsa00640	0.75210572
60	Tyrosine metabolism_Homo sapiens_hsa00350	0.71975677
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68566279
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66759898
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.66694242
64	Serotonergic synapse_Homo sapiens_hsa04726	0.65223278
65	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.64765235
66	Homologous recombination_Homo sapiens_hsa03440	0.64623788
67	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.64299541
68	Metabolic pathways_Homo sapiens_hsa01100	0.64238339
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56464054
70	Purine metabolism_Homo sapiens_hsa00230	0.53150793
71	PPAR signaling pathway_Homo sapiens_hsa03320	0.51149291
72	Histidine metabolism_Homo sapiens_hsa00340	0.51104558
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50386882
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.46819121
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.46119066
76	Fatty acid degradation_Homo sapiens_hsa00071	0.42371129
77	Platelet activation_Homo sapiens_hsa04611	0.41155621
78	Basal transcription factors_Homo sapiens_hsa03022	0.40395175
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.40274051
80	Parkinsons disease_Homo sapiens_hsa05012	0.38648607
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.36880819
82	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.36105734
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35769623
84	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.35523893
85	Graft-versus-host disease_Homo sapiens_hsa05332	0.30486222
86	Chemokine signaling pathway_Homo sapiens_hsa04062	0.30068549
87	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.29386434
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.28828751
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.28448651
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.28333880
91	Olfactory transduction_Homo sapiens_hsa04740	0.27850298
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.26716812
93	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.26050305
94	Regulation of autophagy_Homo sapiens_hsa04140	0.24148849
95	Insulin secretion_Homo sapiens_hsa04911	0.24078885
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.22133498
97	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.22061534
98	Mismatch repair_Homo sapiens_hsa03430	0.21756538
99	Alzheimers disease_Homo sapiens_hsa05010	0.21485131
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.19670793

MTND2P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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