ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.33297567
2	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.20850962
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.82591233
4	ATP synthesis coupled proton transport (GO:0015986)	5.82591233
5	respiratory electron transport chain (GO:0022904)	5.57939784
6	electron transport chain (GO:0022900)	5.48591150
7	intestinal absorption (GO:0050892)	4.93544169
8	respiratory chain complex IV assembly (GO:0008535)	4.87250029
9	NADH metabolic process (GO:0006734)	4.86710597
10	positive regulation of respiratory burst (GO:0060267)	4.47403790
11	oxidative phosphorylation (GO:0006119)	4.20738068
12	cytochrome complex assembly (GO:0017004)	4.05760068
13	cytidine metabolic process (GO:0046087)	4.03968331
14	cytidine catabolic process (GO:0006216)	4.03968331
15	cytidine deamination (GO:0009972)	4.03968331
16	regulation of guanylate cyclase activity (GO:0031282)	3.99721300
17	angiotensin maturation (GO:0002003)	3.92506898
18	signal transduction involved in regulation of gene expression (GO:0023019)	3.75249780
19	regulation of mesoderm development (GO:2000380)	3.69588281
20	hydrogen ion transmembrane transport (GO:1902600)	3.65052826
21	fucose catabolic process (GO:0019317)	3.63042147
22	L-fucose metabolic process (GO:0042354)	3.63042147
23	L-fucose catabolic process (GO:0042355)	3.63042147
24	ATP biosynthetic process (GO:0006754)	3.55501940
25	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.50040965
26	regulation of cellular extravasation (GO:0002691)	3.46323743
27	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.45618201
28	proton transport (GO:0015992)	3.38948512
29	epoxygenase P450 pathway (GO:0019373)	3.38815598
30	phenol-containing compound catabolic process (GO:0019336)	3.36134739
31	hydrogen transport (GO:0006818)	3.31934042
32	protein complex biogenesis (GO:0070271)	3.17846798
33	nodal signaling pathway (GO:0038092)	3.17827439
34	sulfation (GO:0051923)	3.17749681
35	aerobic respiration (GO:0009060)	3.14918042
36	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.14252189
37	sleep (GO:0030431)	3.10558761
38	regulation of dendritic cell antigen processing and presentation (GO:0002604)	3.10372034
39	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.08913420
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.06158627
41	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.01708039
42	regulation of vitamin metabolic process (GO:0030656)	2.98367326
43	negative regulation of hormone biosynthetic process (GO:0032353)	2.96258969
44	NADH dehydrogenase complex assembly (GO:0010257)	2.96006489
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.96006489
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.96006489
47	anterior/posterior axis specification, embryo (GO:0008595)	2.95987557
48	sequestering of extracellular ligand from receptor (GO:0035581)	2.91325656
49	endoderm formation (GO:0001706)	2.90440028
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.89477535
51	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.86857369
52	DNA replication checkpoint (GO:0000076)	2.85169599
53	negative regulation of hormone metabolic process (GO:0032351)	2.82472626
54	phospholipid scrambling (GO:0017121)	2.79784258
55	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2.79193447
56	endocrine process (GO:0050886)	2.79193447
57	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.79193447
58	kidney morphogenesis (GO:0060993)	2.78356150
59	positive regulation of guanylate cyclase activity (GO:0031284)	2.75801779
60	cellular ketone body metabolic process (GO:0046950)	2.73546507
61	regulation of systemic arterial blood pressure (GO:0003073)	2.73045549
62	cobalamin metabolic process (GO:0009235)	2.70936465
63	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.69331052
64	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.67662084
65	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.66912216
66	oxaloacetate metabolic process (GO:0006107)	2.66758229
67	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.64124912
68	peptide hormone processing (GO:0016486)	2.63762703
69	dopamine transport (GO:0015872)	2.63760986
70	fat-soluble vitamin biosynthetic process (GO:0042362)	2.62146105
71	fucosylation (GO:0036065)	2.61738429
72	cellular response to zinc ion (GO:0071294)	2.61501818
73	digestion (GO:0007586)	2.59219396
74	positive regulation of pseudopodium assembly (GO:0031274)	2.58113757
75	vitamin biosynthetic process (GO:0009110)	2.55500412
76	vitamin A metabolic process (GO:0006776)	2.54001346
77	positive regulation of antigen processing and presentation (GO:0002579)	2.53263325
78	protein neddylation (GO:0045116)	2.52203011
79	antigen processing and presentation of endogenous antigen (GO:0019883)	2.51764116
80	regulation of cGMP biosynthetic process (GO:0030826)	2.51725954
81	cGMP-mediated signaling (GO:0019934)	2.50395577
82	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.50165593
83	regulation of pseudopodium assembly (GO:0031272)	2.48883200
84	water-soluble vitamin biosynthetic process (GO:0042364)	2.48854719
85	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.47684411
86	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.47365590
87	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.47079390
88	glutathione derivative biosynthetic process (GO:1901687)	2.45513105
89	glutathione derivative metabolic process (GO:1901685)	2.45513105
90	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.45153812
91	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.45153812
92	regulation of respiratory burst (GO:0060263)	2.42607102
93	alkaloid metabolic process (GO:0009820)	2.42228330
94	regulation of cGMP metabolic process (GO:0030823)	2.42113242
95	negative regulation of epidermal cell differentiation (GO:0045605)	2.41631871
96	cellular respiration (GO:0045333)	2.40608386
97	regulation of cellular respiration (GO:0043457)	2.39338071
98	thalamus development (GO:0021794)	2.38288732
99	response to histamine (GO:0034776)	2.38014170
100	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.37105965

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.76150094
2	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	3.25193565
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.89084725
4	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.88729603
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.83311352
6	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.80536216
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.65805257
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.62744349
9	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.47580359
10	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.40503795
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.40055968
12	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.36897010
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32870532
14	GATA4_25053715_ChIP-Seq_YYC3_Human	2.23094621
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20378141
16	BCAT_22108803_ChIP-Seq_LS180_Human	2.11524985
17	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.04104236
18	GATA1_22025678_ChIP-Seq_K562_Human	1.93307245
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89401170
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.86509162
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.86054202
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.78298780
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.75964337
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.73183966
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71343711
26	E2F7_22180533_ChIP-Seq_HELA_Human	1.63831935
27	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.54883624
28	FUS_26573619_Chip-Seq_HEK293_Human	1.53766701
29	NANOG_20526341_ChIP-Seq_ESCs_Human	1.52503516
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.51602946
31	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.48570478
32	AR_20517297_ChIP-Seq_VCAP_Human	1.47475969
33	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.44258627
34	ZNF274_21170338_ChIP-Seq_K562_Hela	1.42739090
35	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42628181
36	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42628181
37	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.40949315
38	GATA6_25053715_ChIP-Seq_YYC3_Human	1.39214363
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.38486959
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.37610011
41	CDX2_22108803_ChIP-Seq_LS180_Human	1.34693263
42	EWS_26573619_Chip-Seq_HEK293_Human	1.34330278
43	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.33135402
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.32973729
45	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.32312382
46	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.32312382
47	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.32312382
48	P53_21459846_ChIP-Seq_SAOS-2_Human	1.30633193
49	MYC_19829295_ChIP-Seq_ESCs_Human	1.28962120
50	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.28668996
51	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.24165923
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23683544
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23513097
54	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22056794
55	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20727926
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.20395809
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19632573
58	RBPJ_21746931_ChIP-Seq_IB4_Human	1.18931786
59	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.17907817
60	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17734615
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15148741
62	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.14917046
63	ERG_20517297_ChIP-Seq_VCAP_Human	1.14539834
64	VDR_23849224_ChIP-Seq_CD4+_Human	1.14512517
65	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.13452321
66	STAT1_20625510_ChIP-Seq_HELA_Human	1.13120777
67	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12808790
68	ETV1_20927104_ChIP-Seq_GIST48_Human	1.11618612
69	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10207642
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09468970
71	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.09274601
72	GATA3_26560356_Chip-Seq_TH1_Human	1.08648288
73	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.08543344
74	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.06617908
75	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.06223802
76	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.05755631
77	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.05577925
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05482870
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05378416
80	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.05041025
81	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04820572
82	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04806872
83	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04629349
84	TP53_22573176_ChIP-Seq_HFKS_Human	1.02940687
85	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.02569841
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.01901967
87	P300_19829295_ChIP-Seq_ESCs_Human	1.01327017
88	NCOR_22424771_ChIP-Seq_293T_Human	1.01209860
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01065959
90	AR_25329375_ChIP-Seq_VCAP_Human	1.00172278
91	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00106172
92	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00106172
93	NFYB_21822215_ChIP-Seq_K562_Human	0.99965981
94	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.99140502
95	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.98863186
96	PHF8_20622853_ChIP-Seq_HELA_Human	0.98767478
97	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.98549656
98	ELK1_19687146_ChIP-ChIP_HELA_Human	0.97901558
99	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.97826187
100	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.97745091

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	4.49097028
2	MP0009379_abnormal_foot_pigmentation	4.38995892
3	MP0001666_abnormal_nutrient_absorption	2.87274641
4	MP0004043_abnormal_pH_regulation	2.60753524
5	MP0003283_abnormal_digestive_organ	2.60493099
6	MP0002837_dystrophic_cardiac_calcinosis	2.56564869
7	MP0002254_reproductive_system_inflammat	2.51435648
8	MP0004215_abnormal_myocardial_fiber	2.41575458
9	MP0002139_abnormal_hepatobiliary_system	2.29845850
10	MP0001188_hyperpigmentation	2.27660931
11	MP0003806_abnormal_nucleotide_metabolis	2.23547422
12	MP0001873_stomach_inflammation	2.20673424
13	MP0006072_abnormal_retinal_apoptosis	2.17352903
14	MP0006036_abnormal_mitochondrial_physio	2.17232632
15	MP0004019_abnormal_vitamin_homeostasis	2.15043984
16	MP0005332_abnormal_amino_acid	2.05155769
17	MP0002138_abnormal_hepatobiliary_system	1.98261958
18	MP0008872_abnormal_physiological_respon	1.95307281
19	MP0002876_abnormal_thyroid_physiology	1.91237923
20	MP0008775_abnormal_heart_ventricle	1.89983022
21	MP0010155_abnormal_intestine_physiology	1.86477204
22	MP0005671_abnormal_response_to	1.82919904
23	MP0000685_abnormal_immune_system	1.77383680
24	MP0000013_abnormal_adipose_tissue	1.68794611
25	MP0003890_abnormal_embryonic-extraembry	1.68014401
26	MP0010329_abnormal_lipoprotein_level	1.67535754
27	MP0001664_abnormal_digestion	1.60370653
28	MP0002396_abnormal_hematopoietic_system	1.58860506
29	MP0002166_altered_tumor_susceptibility	1.58628155
30	MP0003693_abnormal_embryo_hatching	1.58243237
31	MP0003567_abnormal_fetal_cardiomyocyte	1.52791853
32	MP0005365_abnormal_bile_salt	1.51921588
33	MP0005085_abnormal_gallbladder_physiolo	1.46734787
34	MP0003866_abnormal_defecation	1.44830547
35	MP0001790_abnormal_immune_system	1.41686662
36	MP0005387_immune_system_phenotype	1.41686662
37	MP0004145_abnormal_muscle_electrophysio	1.37347189
38	MP0000490_abnormal_crypts_of	1.35869908
39	MP0009643_abnormal_urine_homeostasis	1.34914646
40	MP0001835_abnormal_antigen_presentation	1.34583456
41	MP0005670_abnormal_white_adipose	1.33795257
42	MP0000477_abnormal_intestine_morphology	1.31989115
43	MP0005503_abnormal_tendon_morphology	1.31605008
44	MP0001765_abnormal_ion_homeostasis	1.30945173
45	MP0005645_abnormal_hypothalamus_physiol	1.29441523
46	MP0004147_increased_porphyrin_level	1.29414466
47	MP0003941_abnormal_skin_development	1.25745751
48	MP0005636_abnormal_mineral_homeostasis	1.24288324
49	MP0000230_abnormal_systemic_arterial	1.21919055
50	MP0002127_abnormal_cardiovascular_syste	1.21913903
51	MP0004957_abnormal_blastocyst_morpholog	1.20086533
52	MP0003718_maternal_effect	1.19829759
53	MP0000462_abnormal_digestive_system	1.19625524
54	MP0002693_abnormal_pancreas_physiology	1.18808383
55	MP0003137_abnormal_impulse_conducting	1.16840720
56	MP0001485_abnormal_pinna_reflex	1.16041227
57	MP0001756_abnormal_urination	1.12056485
58	MP0009333_abnormal_splenocyte_physiolog	1.11668679
59	MP0001544_abnormal_cardiovascular_syste	1.11315701
60	MP0005385_cardiovascular_system_phenoty	1.11315701
61	MP0000538_abnormal_urinary_bladder	1.11212712
62	MP0004085_abnormal_heartbeat	1.10729000
63	MP0002938_white_spotting	1.10308661
64	MP0005448_abnormal_energy_balance	1.09114029
65	MP0001661_extended_life_span	1.08830219
66	MP0003119_abnormal_digestive_system	1.07747968
67	MP0001764_abnormal_homeostasis	1.06598338
68	MP0005330_cardiomyopathy	1.06115480
69	MP0002006_tumorigenesis	1.02116249
70	MP0004264_abnormal_extraembryonic_tissu	0.98786316
71	MP0002909_abnormal_adrenal_gland	0.96946199
72	MP0000470_abnormal_stomach_morphology	0.96522610
73	MP0002277_abnormal_respiratory_mucosa	0.95997527
74	MP0005381_digestive/alimentary_phenotyp	0.91746638
75	MP0002078_abnormal_glucose_homeostasis	0.89777959
76	MP0000751_myopathy	0.87171450
77	MP0010352_gastrointestinal_tract_polyps	0.85283034
78	MP0009840_abnormal_foam_cell	0.83152447
79	MP0001944_abnormal_pancreas_morphology	0.82871961
80	MP0006138_congestive_heart_failure	0.82352205
81	MP0004885_abnormal_endolymph	0.81820451
82	MP0001663_abnormal_digestive_system	0.81285375
83	MP0002118_abnormal_lipid_homeostasis	0.79061215
84	MP0000631_abnormal_neuroendocrine_gland	0.76111789
85	MP0005620_abnormal_muscle_contractility	0.75940211
86	MP0001881_abnormal_mammary_gland	0.75869209
87	MP0009384_cardiac_valve_regurgitation	0.74629762
88	MP0002136_abnormal_kidney_physiology	0.74027685
89	MP0005174_abnormal_tail_pigmentation	0.74009780
90	MP0005535_abnormal_body_temperature	0.72899926
91	MP0003953_abnormal_hormone_level	0.71552545
92	MP0002933_joint_inflammation	0.70453869
93	MP0003195_calcinosis	0.69540198
94	MP0000678_abnormal_parathyroid_gland	0.69220875
95	MP0001800_abnormal_humoral_immune	0.69143586
96	MP0009642_abnormal_blood_homeostasis	0.67496500
97	MP0004484_altered_response_of	0.66388711
98	MP0002102_abnormal_ear_morphology	0.64138087
99	MP0004084_abnormal_cardiac_muscle	0.63968435
100	MP0002106_abnormal_muscle_physiology	0.63958077

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.42122414
2	Decreased circulating renin level (HP:0003351)	4.27681720
3	Abnormality of vitamin B metabolism (HP:0004340)	4.19801757
4	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.88328021
5	Acute necrotizing encephalopathy (HP:0006965)	3.49259311
6	Abnormality of urine glucose concentration (HP:0011016)	3.47999153
7	Glycosuria (HP:0003076)	3.47999153
8	Abnormality of proline metabolism (HP:0010907)	3.40543265
9	Hydroxyprolinuria (HP:0003080)	3.40543265
10	Hypoglycemic coma (HP:0001325)	3.24299269
11	Megaloblastic anemia (HP:0001889)	3.22562431
12	Mitochondrial inheritance (HP:0001427)	3.13054661
13	Hyperinsulinemic hypoglycemia (HP:0000825)	3.11486511
14	Congenital, generalized hypertrichosis (HP:0004540)	3.11059084
15	Acute encephalopathy (HP:0006846)	3.04162020
16	Abnormal mitochondria in muscle tissue (HP:0008316)	2.97987554
17	Abnormality of vitamin metabolism (HP:0100508)	2.93318950
18	Hepatic necrosis (HP:0002605)	2.86554709
19	Macrocytic anemia (HP:0001972)	2.85922915
20	Progressive macrocephaly (HP:0004481)	2.83124936
21	Abnormality of renin-angiotensin system (HP:0000847)	2.79444902
22	Increased CSF lactate (HP:0002490)	2.74098804
23	Malnutrition (HP:0004395)	2.69290966
24	Short hallux (HP:0010109)	2.65871111
25	Hypoglycemic seizures (HP:0002173)	2.60449851
26	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.59950235
27	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.58518761
28	Nausea (HP:0002018)	2.57149315
29	Metabolic alkalosis (HP:0200114)	2.56469268
30	Facial shape deformation (HP:0011334)	2.54853962
31	Potter facies (HP:0002009)	2.54853962
32	Hepatocellular necrosis (HP:0001404)	2.53843259
33	Congenital sensorineural hearing impairment (HP:0008527)	2.53010210
34	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.52656198
35	Dicarboxylic aciduria (HP:0003215)	2.52656198
36	Lipid accumulation in hepatocytes (HP:0006561)	2.50725627
37	Symptomatic seizures (HP:0011145)	2.49569552
38	Abnormal number of erythroid precursors (HP:0012131)	2.48188157
39	Cerebral edema (HP:0002181)	2.47109924
40	Increased hepatocellular lipid droplets (HP:0006565)	2.45531542
41	Increased purine levels (HP:0004368)	2.43278295
42	Hyperuricemia (HP:0002149)	2.43278295
43	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.39628927
44	Gout (HP:0001997)	2.39453936
45	Large for gestational age (HP:0001520)	2.39421143
46	Hyperglycinuria (HP:0003108)	2.38087019
47	Palpitations (HP:0001962)	2.37018327
48	Abnormality of homocysteine metabolism (HP:0010919)	2.34670176
49	Homocystinuria (HP:0002156)	2.34670176
50	Late onset (HP:0003584)	2.32211382
51	Double outlet right ventricle (HP:0001719)	2.26632874
52	Congenital malformation of the right heart (HP:0011723)	2.26632874
53	Widely patent fontanelles and sutures (HP:0004492)	2.26056736
54	Methylmalonic aciduria (HP:0012120)	2.23363563
55	Short middle phalanx of the 5th finger (HP:0004220)	2.21997182
56	Chronic diarrhea (HP:0002028)	2.21895025
57	Abnormality of T cell physiology (HP:0011840)	2.21591568
58	Alkalosis (HP:0001948)	2.17008465
59	Abnormal pancreas size (HP:0012094)	2.15425595
60	IgG deficiency (HP:0004315)	2.14334464
61	Confusion (HP:0001289)	2.13393795
62	Abnormality of cells of the erythroid lineage (HP:0012130)	2.11367295
63	Hyperglycemia (HP:0003074)	2.11138238
64	Abnormal albumin level (HP:0012116)	2.10185005
65	Hypoalbuminemia (HP:0003073)	2.10185005
66	Lethargy (HP:0001254)	2.09403468
67	Petechiae (HP:0000967)	2.07055604
68	Acanthocytosis (HP:0001927)	2.05602405
69	Cerebral palsy (HP:0100021)	2.02656249
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.02646650
71	Limb dystonia (HP:0002451)	2.02644213
72	Tongue fasciculations (HP:0001308)	2.02218142
73	Exertional dyspnea (HP:0002875)	1.99824703
74	Ileus (HP:0002595)	1.98915121
75	Methylmalonic acidemia (HP:0002912)	1.98271526
76	Hyperphosphaturia (HP:0003109)	1.95502032
77	Hyperphosphatemia (HP:0002905)	1.94959136
78	Abnormality of glycine metabolism (HP:0010895)	1.92516145
79	Abnormality of serine family amino acid metabolism (HP:0010894)	1.92516145
80	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91092328
81	Calf muscle hypertrophy (HP:0008981)	1.90100872
82	Atrial fibrillation (HP:0005110)	1.88979844
83	Lactic acidosis (HP:0003128)	1.87404353
84	Shawl scrotum (HP:0000049)	1.86313566
85	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.84556229
86	Metabolic acidosis (HP:0001942)	1.84317236
87	Reticulocytopenia (HP:0001896)	1.82601734
88	Increased muscle lipid content (HP:0009058)	1.82101085
89	Proximal tubulopathy (HP:0000114)	1.82066585
90	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.81088604
91	Unilateral renal agenesis (HP:0000122)	1.80084739
92	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.79340040
93	Gastrointestinal stroma tumor (HP:0100723)	1.78968781
94	Testicular atrophy (HP:0000029)	1.78396952
95	Rectal fistula (HP:0100590)	1.78104752
96	Rectovaginal fistula (HP:0000143)	1.78104752
97	Hypoplasia of the pons (HP:0012110)	1.77853668
98	Muscle hypertrophy of the lower extremities (HP:0008968)	1.77432199
99	Patent foramen ovale (HP:0001655)	1.76688937
100	Aplasia of the musculature (HP:0100854)	1.75325850

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	5.08221943
2	TNIK	3.73918885
3	MYLK	3.70978764
4	AKT3	3.22036196
5	TAOK3	3.20624624
6	VRK2	2.41855376
7	MST4	2.40096673
8	PLK4	2.27847863
9	NME1	2.18176581
10	MAP3K12	2.08072250
11	MAP4K1	2.07536063
12	NUAK1	2.03347620
13	ERN1	2.02013990
14	BUB1	2.01215521
15	BMPR1B	1.94766605
16	NLK	1.91178722
17	DMPK	1.78699113
18	CDK12	1.67024775
19	FRK	1.58646736
20	GRK1	1.57181390
21	STK24	1.53020319
22	MAPK15	1.52061067
23	MAP3K10	1.43833387
24	ADRBK2	1.39256285
25	PINK1	1.36217500
26	PRKG2	1.30264039
27	TLK1	1.29849660
28	MKNK2	1.29563239
29	TEC	1.16242429
30	MAP2K2	1.14143552
31	MAP2K6	1.13657669
32	TTK	1.12981763
33	FGFR4	1.08443682
34	TXK	1.07332194
35	STK3	1.02053359
36	RIPK4	1.01660212
37	CDC7	0.98858628
38	EPHA3	0.97591538
39	MAPKAPK5	0.97411268
40	BRSK2	0.96609446
41	ITK	0.94096955
42	KIT	0.91523561
43	WEE1	0.90181779
44	TAF1	0.87741387
45	TRPM7	0.86149986
46	OXSR1	0.85014177
47	PHKG1	0.78909168
48	PHKG2	0.78909168
49	WNK3	0.75888915
50	NEK2	0.75076800
51	VRK1	0.75039284
52	INSRR	0.74537529
53	MAPK7	0.70690639
54	STK16	0.70675807
55	FLT3	0.70235390
56	PAK3	0.69341690
57	ERBB4	0.68608410
58	CDK8	0.67517328
59	MAP4K2	0.65878950
60	STK4	0.63288525
61	CDK19	0.62305107
62	FGFR2	0.60701674
63	EIF2AK2	0.60681548
64	CAMK2D	0.60627712
65	HIPK2	0.58572367
66	EPHB1	0.57820246
67	ADRBK1	0.57350068
68	MAP3K14	0.56515105
69	CDC42BPA	0.54962474
70	CDK4	0.52927762
71	PTK6	0.52030200
72	SYK	0.51626805
73	NEK1	0.51040988
74	BRD4	0.50611953
75	MELK	0.50106949
76	OBSCN	0.48877635
77	PDK2	0.48615323
78	MST1R	0.48190079
79	MAP3K7	0.47928953
80	PRKG1	0.45411014
81	IKBKB	0.44898856
82	WNK4	0.44718141
83	PNCK	0.43707612
84	CHEK2	0.43680471
85	MAPK11	0.43536800
86	ZAP70	0.43314792
87	PRKAA2	0.42296094
88	MAPKAPK3	0.42079081
89	EPHB2	0.40752238
90	PRKCQ	0.40404917
91	RPS6KA6	0.40190823
92	MAPK12	0.39851490
93	PRKCE	0.36277831
94	ZAK	0.35998198
95	PTK2B	0.34555178
96	MAPKAPK2	0.34293381
97	DAPK2	0.34065430
98	JAK3	0.33194928
99	PRKCA	0.30942490
100	STK10	0.30687203

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.16144357
2	Asthma_Homo sapiens_hsa05310	3.02103793
3	Sulfur metabolism_Homo sapiens_hsa00920	3.01440741
4	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.00664325
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.86751978
6	Fat digestion and absorption_Homo sapiens_hsa04975	2.85934743
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.85591065
8	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.82994332
9	Parkinsons disease_Homo sapiens_hsa05012	2.48949338
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.31765263
11	Allograft rejection_Homo sapiens_hsa05330	2.24527874
12	Mineral absorption_Homo sapiens_hsa04978	2.09644685
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.08295528
14	Renin-angiotensin system_Homo sapiens_hsa04614	2.02868205
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.97036725
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.94579406
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.82413907
18	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.71329787
19	Protein export_Homo sapiens_hsa03060	1.68244488
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.68005672
21	Protein digestion and absorption_Homo sapiens_hsa04974	1.66278285
22	Ribosome_Homo sapiens_hsa03010	1.59114743
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.58484588
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57312550
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.47344611
26	Proteasome_Homo sapiens_hsa03050	1.46868532
27	Alzheimers disease_Homo sapiens_hsa05010	1.44455841
28	Folate biosynthesis_Homo sapiens_hsa00790	1.42157372
29	Homologous recombination_Homo sapiens_hsa03440	1.36765606
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.33925435
31	Caffeine metabolism_Homo sapiens_hsa00232	1.25937579
32	Huntingtons disease_Homo sapiens_hsa05016	1.24708433
33	Glutathione metabolism_Homo sapiens_hsa00480	1.23842033
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23589100
35	One carbon pool by folate_Homo sapiens_hsa00670	1.20886748
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.17839853
37	Retinol metabolism_Homo sapiens_hsa00830	1.17693929
38	Fatty acid degradation_Homo sapiens_hsa00071	1.17002360
39	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.15934537
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13088218
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.11678836
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.10035175
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.09823996
44	Arginine biosynthesis_Homo sapiens_hsa00220	1.08108377
45	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.05037561
46	Histidine metabolism_Homo sapiens_hsa00340	1.04803833
47	Insulin secretion_Homo sapiens_hsa04911	0.99054084
48	Butanoate metabolism_Homo sapiens_hsa00650	0.92674677
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92027363
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.91536505
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90988650
52	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.90469757
53	Antigen processing and presentation_Homo sapiens_hsa04612	0.87305944
54	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.86096654
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.85438599
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.85229722
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82953532
58	PPAR signaling pathway_Homo sapiens_hsa03320	0.82044670
59	RNA degradation_Homo sapiens_hsa03018	0.75292697
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71806030
61	Viral myocarditis_Homo sapiens_hsa05416	0.71333836
62	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.71030641
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69764790
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.65577263
65	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.65212124
66	Propanoate metabolism_Homo sapiens_hsa00640	0.64594136
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.64155519
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.61564886
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57997934
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.57415295
71	Bile secretion_Homo sapiens_hsa04976	0.57091436
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.56568113
73	Renin secretion_Homo sapiens_hsa04924	0.55913582
74	Mismatch repair_Homo sapiens_hsa03430	0.52953284
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52551406
76	Pancreatic secretion_Homo sapiens_hsa04972	0.52044431
77	Cocaine addiction_Homo sapiens_hsa05030	0.51609854
78	RNA polymerase_Homo sapiens_hsa03020	0.51512691
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51240657
80	Fatty acid elongation_Homo sapiens_hsa00062	0.48473280
81	Purine metabolism_Homo sapiens_hsa00230	0.47023891
82	Sulfur relay system_Homo sapiens_hsa04122	0.46353854
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.45880898
84	Metabolic pathways_Homo sapiens_hsa01100	0.44325867
85	Peroxisome_Homo sapiens_hsa04146	0.43979887
86	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.41796827
87	Nitrogen metabolism_Homo sapiens_hsa00910	0.39800106
88	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.38764252
89	Serotonergic synapse_Homo sapiens_hsa04726	0.36279230
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35716580
91	Galactose metabolism_Homo sapiens_hsa00052	0.35418261
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.32219764
93	Leishmaniasis_Homo sapiens_hsa05140	0.31157634
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.30242929
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.28921413
96	Amphetamine addiction_Homo sapiens_hsa05031	0.28408305
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.25308827
98	DNA replication_Homo sapiens_hsa03030	0.24740870
99	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.23772494
100	Spliceosome_Homo sapiens_hsa03040	0.23578132

MTND4P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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