MTND4P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.39980399
2modulation by symbiont of host defense response (GO:0052031)5.37063300
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.37063300
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.37063300
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.37063300
6modulation by symbiont of host immune response (GO:0052553)5.37063300
7positive regulation by symbiont of host defense response (GO:0052509)5.37063300
8cellular response to ethanol (GO:0071361)5.34338331
9detection of molecule of bacterial origin (GO:0032490)5.18567946
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.74945788
11cellular extravasation (GO:0045123)4.70812766
12microglial cell activation (GO:0001774)4.69400528
13macrophage activation involved in immune response (GO:0002281)4.64309871
14mating behavior (GO:0007617)4.60847396
15eosinophil chemotaxis (GO:0048245)4.57285140
16neutrophil mediated immunity (GO:0002446)4.51656914
17negative regulation of interleukin-12 production (GO:0032695)4.42328408
18positive regulation of granulocyte differentiation (GO:0030854)4.40888750
19response to host immune response (GO:0052572)4.38707877
20response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.38707877
21eosinophil migration (GO:0072677)4.28296115
22regulation of gamma-delta T cell activation (GO:0046643)4.12502673
23response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.04055587
24response to host (GO:0075136)4.04055587
25response to host defenses (GO:0052200)4.04055587
26myeloid leukocyte mediated immunity (GO:0002444)4.02328329
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.89175337
28regulation of T cell tolerance induction (GO:0002664)3.79150717
29histone H3-K36 demethylation (GO:0070544)3.78727689
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.78557700
31macrophage activation (GO:0042116)3.78422817
32regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.75513866
33interferon-gamma production (GO:0032609)3.72311290
34cellular response to exogenous dsRNA (GO:0071360)3.70651211
35regulation of interferon-beta biosynthetic process (GO:0045357)3.69812839
36neutrophil activation involved in immune response (GO:0002283)3.69180786
37regulation of tolerance induction (GO:0002643)3.64268979
38regulation of gamma-delta T cell differentiation (GO:0045586)3.56859674
39regulation of B cell receptor signaling pathway (GO:0050855)3.56090098
40regulation of MHC class I biosynthetic process (GO:0045343)3.55207907
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.49908071
42response to type I interferon (GO:0034340)3.47756436
43detection of external biotic stimulus (GO:0098581)3.44797897
44cellular response to type I interferon (GO:0071357)3.44424184
45type I interferon signaling pathway (GO:0060337)3.44424184
46hepatocyte apoptotic process (GO:0097284)3.41911738
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.41712196
48negative regulation of T cell mediated immunity (GO:0002710)3.39605631
49myeloid cell activation involved in immune response (GO:0002275)3.38028465
50I-kappaB phosphorylation (GO:0007252)3.37032515
51T cell migration (GO:0072678)3.33374925
52neutrophil activation (GO:0042119)3.24003029
53activated T cell proliferation (GO:0050798)3.21322530
54positive regulation of interleukin-17 production (GO:0032740)3.19649351
55defense response to protozoan (GO:0042832)3.17800236
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.17779603
57granulocyte activation (GO:0036230)3.16270068
58response to peptidoglycan (GO:0032494)3.15115462
59regulation of histone H3-K27 methylation (GO:0061085)3.13315989
60positive regulation of type 2 immune response (GO:0002830)3.10576007
61histone mRNA catabolic process (GO:0071044)3.10136003
62positive regulation of tolerance induction (GO:0002645)3.09832603
63protein prenylation (GO:0018342)3.08351090
64prenylation (GO:0097354)3.08351090
65regulation of lymphocyte chemotaxis (GO:1901623)3.05950933
66leukotriene biosynthetic process (GO:0019370)3.04330009
67production of molecular mediator involved in inflammatory response (GO:0002532)3.03650788
68detection of biotic stimulus (GO:0009595)3.01316869
69detection of other organism (GO:0098543)3.01112056
70regulation of interleukin-12 biosynthetic process (GO:0045075)3.00955679
71response to protozoan (GO:0001562)3.00328031
72positive regulation of interferon-alpha production (GO:0032727)2.97965461
73B cell receptor signaling pathway (GO:0050853)2.97104434
74regulation of interleukin-17 production (GO:0032660)2.95373683
75interferon-gamma-mediated signaling pathway (GO:0060333)2.92844070
76positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.92443895
77T-helper 1 type immune response (GO:0042088)2.91340423
78genitalia morphogenesis (GO:0035112)2.90654672
79regulation of macrophage chemotaxis (GO:0010758)2.90634457
80negative regulation of lymphocyte mediated immunity (GO:0002707)2.89596781
81negative regulation of cell killing (GO:0031342)2.89132867
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89132867
83natural killer cell activation involved in immune response (GO:0002323)2.86599196
84positive regulation of cAMP-mediated signaling (GO:0043950)2.84589164
85regulation of interferon-alpha production (GO:0032647)2.84029146
86mast cell activation (GO:0045576)2.83419944
87positive regulation of interferon-beta production (GO:0032728)2.83195465
88regulation of interferon-beta production (GO:0032648)2.83182473
89regulation of granulocyte differentiation (GO:0030852)2.80484011
90response to interferon-alpha (GO:0035455)2.75914717
91positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73328670
92negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.71878217
93lymphocyte chemotaxis (GO:0048247)2.70298736
94interkinetic nuclear migration (GO:0022027)2.68136223
95T cell proliferation (GO:0042098)2.67401481
96peptidyl-lysine trimethylation (GO:0018023)2.67300526
97myeloid leukocyte activation (GO:0002274)2.66312370
98interferon-gamma secretion (GO:0072643)2.65543392
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65263524
100T cell activation involved in immune response (GO:0002286)2.64546818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.22766760
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.04565970
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.93751132
4GATA1_22025678_ChIP-Seq_K562_Human3.55648169
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.41089320
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.21757486
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.01030600
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.00721962
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80976107
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73024713
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62324587
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.59186044
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48162381
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.22571716
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.18998778
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.17852254
17RUNX_20019798_ChIP-Seq_JUKART_Human2.14949618
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.09401456
19VDR_24787735_ChIP-Seq_THP-1_Human1.99531370
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99234060
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91334465
22SCL_19346495_ChIP-Seq_HPC-7_Human1.89137994
23MYB_26560356_Chip-Seq_TH2_Human1.78020372
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70612326
25SPI1_23127762_ChIP-Seq_K562_Human1.68459945
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66521372
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64709953
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58717936
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56166686
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.53146501
31ER_23166858_ChIP-Seq_MCF-7_Human1.46664452
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44667692
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43678458
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40873716
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40230402
36GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39418463
37SPI1_23547873_ChIP-Seq_NB4_Human1.37487232
38GATA3_26560356_Chip-Seq_TH2_Human1.37203552
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37040477
40PRDM14_20953172_ChIP-Seq_ESCs_Human1.35235095
41GATA3_27048872_Chip-Seq_THYMUS_Human1.32512746
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.31150857
43MYB_26560356_Chip-Seq_TH1_Human1.29876561
44TAF15_26573619_Chip-Seq_HEK293_Human1.28045178
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26638684
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23550293
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19166006
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19166006
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16613958
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.13259479
51VDR_24763502_ChIP-Seq_THP-1_Human1.09906683
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09213008
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09114892
54VDR_22108803_ChIP-Seq_LS180_Human1.08978445
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07673536
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07625282
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06164520
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05585937
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05370233
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04940068
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03720844
62MAF_26560356_Chip-Seq_TH1_Human1.03590122
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02956510
64GATA3_26560356_Chip-Seq_TH1_Human1.02227619
65STAT3_23295773_ChIP-Seq_U87_Human1.01772903
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00733862
67EZH2_27294783_Chip-Seq_NPCs_Mouse0.99863570
68PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98866114
69PU_27001747_Chip-Seq_BMDM_Mouse0.97895218
70GATA1_19941827_ChIP-Seq_MEL_Mouse0.97830167
71P300_19829295_ChIP-Seq_ESCs_Human0.96975532
72AR_21572438_ChIP-Seq_LNCaP_Human0.96516199
73SMRT_27268052_Chip-Seq_Bcells_Human0.96374219
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96250432
75SMAD4_21799915_ChIP-Seq_A2780_Human0.94104921
76GBX2_23144817_ChIP-Seq_PC3_Human0.94045253
77SALL4_22934838_ChIP-ChIP_CD34+_Human0.93726681
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.93412058
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93172652
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92133727
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91734410
82ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90754489
83ESR1_20079471_ChIP-ChIP_T-47D_Human0.90501850
84GATA2_19941826_ChIP-Seq_K562_Human0.90292043
85OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90138350
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.89565218
87TCF4_23295773_ChIP-Seq_U87_Human0.87065046
88CBP_20019798_ChIP-Seq_JUKART_Human0.86602676
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86602676
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86392611
91CDX2_22108803_ChIP-Seq_LS180_Human0.85627063
92TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.85625768
93TP63_23658742_ChIP-Seq_EP156T_Human0.85419660
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.85019736
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84307280
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83828743
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83557104
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82744271
99TP53_16413492_ChIP-PET_HCT116_Human0.82237449
100AHR_22903824_ChIP-Seq_MCF-7_Human0.82017945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.17634182
2MP0003724_increased_susceptibility_to4.32135448
3MP0003950_abnormal_plasma_membrane3.80790802
4MP0001835_abnormal_antigen_presentation3.70392092
5MP0003656_abnormal_erythrocyte_physiolo3.41066306
6MP0008877_abnormal_DNA_methylation2.76261166
7MP0001800_abnormal_humoral_immune2.60487757
8MP0005000_abnormal_immune_tolerance2.51141749
9MP0003787_abnormal_imprinting2.49891516
10MP0009785_altered_susceptibility_to2.44304692
11MP0005174_abnormal_tail_pigmentation2.34661530
12MP0004381_abnormal_hair_follicle2.34548681
13MP0003303_peritoneal_inflammation2.19331098
14MP0002419_abnormal_innate_immunity2.19005311
15MP0002723_abnormal_immune_serum2.15972464
16MP0005671_abnormal_response_to2.11985364
17MP0006082_CNS_inflammation2.10900550
18MP0003172_abnormal_lysosome_physiology2.09805220
19MP0000015_abnormal_ear_pigmentation2.07532407
20MP0005025_abnormal_response_to2.06239813
21MP0001790_abnormal_immune_system2.04823906
22MP0005387_immune_system_phenotype2.04823906
23MP0002452_abnormal_antigen_presenting2.02046459
24MP0003436_decreased_susceptibility_to2.00468703
25MP0002396_abnormal_hematopoietic_system1.95904558
26MP0004130_abnormal_muscle_cell1.93787236
27MP0002166_altered_tumor_susceptibility1.91156509
28MP0000685_abnormal_immune_system1.91150393
29MP0002420_abnormal_adaptive_immunity1.86952321
30MP0001819_abnormal_immune_cell1.84639185
31MP0002148_abnormal_hypersensitivity_rea1.79792487
32MP0005310_abnormal_salivary_gland1.76229213
33MP0003195_calcinosis1.69312380
34MP0002009_preneoplasia1.66355163
35MP0000371_diluted_coat_color1.64617417
36MP0003763_abnormal_thymus_physiology1.63892146
37MP0008057_abnormal_DNA_replication1.60787922
38MP0002398_abnormal_bone_marrow1.58382236
39MP0000716_abnormal_immune_system1.49136824
40MP0005464_abnormal_platelet_physiology1.49066901
41MP0002405_respiratory_system_inflammati1.46437453
42MP0002332_abnormal_exercise_endurance1.41919929
43MP0005409_darkened_coat_color1.37210926
44MP0009278_abnormal_bone_marrow1.36944420
45MP0001533_abnormal_skeleton_physiology1.36501844
46MP0003690_abnormal_glial_cell1.32590995
47MP0009764_decreased_sensitivity_to1.31841054
48MP0003183_abnormal_peptide_metabolism1.31593152
49MP0002006_tumorigenesis1.28269198
50MP0004883_abnormal_blood_vessel1.26838013
51MP0000689_abnormal_spleen_morphology1.26295826
52MP0001845_abnormal_inflammatory_respons1.25104164
53MP0004808_abnormal_hematopoietic_stem1.24997783
54MP0003300_gastrointestinal_ulcer1.22434657
55MP0009333_abnormal_splenocyte_physiolog1.21943003
56MP0003252_abnormal_bile_duct1.19761827
57MP0002429_abnormal_blood_cell1.14408504
58MP0003828_pulmonary_edema1.12098126
59MP0002722_abnormal_immune_system1.08601764
60MP0004947_skin_inflammation1.08040617
61MP0008469_abnormal_protein_level1.05706577
62MP0003191_abnormal_cellular_cholesterol1.03906033
63MP0003045_fibrosis1.03882746
64MP0005164_abnormal_response_to1.03668017
65MP0005167_abnormal_blood-brain_barrier1.02747630
66MP0005379_endocrine/exocrine_gland_phen1.00172528
67MP0005410_abnormal_fertilization0.98914453
68MP0001502_abnormal_circadian_rhythm0.97250867
69MP0000703_abnormal_thymus_morphology0.96716972
70MP0002877_abnormal_melanocyte_morpholog0.95245623
71MP0002163_abnormal_gland_morphology0.95205726
72MP0003448_altered_tumor_morphology0.92894893
73MP0004185_abnormal_adipocyte_glucose0.91588895
74MP0000427_abnormal_hair_cycle0.88186498
75MP0002132_abnormal_respiratory_system0.85635109
76MP0005397_hematopoietic_system_phenotyp0.84975648
77MP0001545_abnormal_hematopoietic_system0.84975648
78MP0002693_abnormal_pancreas_physiology0.84609248
79MP0002075_abnormal_coat/hair_pigmentati0.83443530
80MP0000383_abnormal_hair_follicle0.80253410
81MP0005075_abnormal_melanosome_morpholog0.79908798
82MP0002998_abnormal_bone_remodeling0.79717035
83MP0004134_abnormal_chest_morphology0.78015753
84MP0003646_muscle_fatigue0.77174924
85MP0002095_abnormal_skin_pigmentation0.75294483
86MP0010155_abnormal_intestine_physiology0.75022537
87MP0001853_heart_inflammation0.74023011
88MP0003866_abnormal_defecation0.71147307
89MP0009115_abnormal_fat_cell0.70948883
90MP0010678_abnormal_skin_adnexa0.69856769
91MP0000858_altered_metastatic_potential0.69773246
92MP0001186_pigmentation_phenotype0.69654083
93MP0009763_increased_sensitivity_to0.65729013
94MP0005647_abnormal_sex_gland0.63943417
95MP0003121_genomic_imprinting0.63222512
96MP0001851_eye_inflammation0.63089573
97MP0005451_abnormal_body_composition0.62305961
98MP0004484_altered_response_of0.61155977
99MP0003075_altered_response_to0.58339878
100MP0001873_stomach_inflammation0.57877263

Predicted human phenotypes

RankGene SetZ-score
1Recurrent cutaneous fungal infections (HP:0011370)4.55332499
2Chronic mucocutaneous candidiasis (HP:0002728)4.55332499
3Retrobulbar optic neuritis (HP:0100654)4.49673784
4Optic neuritis (HP:0100653)4.49673784
5Recurrent bacterial skin infections (HP:0005406)4.48977605
6Genetic anticipation (HP:0003743)4.26145014
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.18388807
8Orchitis (HP:0100796)4.17445850
9Abnormality of the pons (HP:0007361)4.12821938
10Duplicated collecting system (HP:0000081)4.09484061
11Large for gestational age (HP:0001520)3.95175076
12Recurrent fungal infections (HP:0002841)3.81384689
13Urethral obstruction (HP:0000796)3.81076913
14Widely spaced teeth (HP:0000687)3.73913588
15Myositis (HP:0100614)3.70981864
163-Methylglutaconic aciduria (HP:0003535)3.70104539
17Recurrent abscess formation (HP:0002722)3.67932144
18T lymphocytopenia (HP:0005403)3.66864843
19Recurrent gram-negative bacterial infections (HP:0005420)3.64909016
20Recurrent skin infections (HP:0001581)3.60263415
21Abnormality of the renal collecting system (HP:0004742)3.58940890
22Abnormality of T cell number (HP:0011839)3.53016637
23Fatigue (HP:0012378)3.47814345
24Abnormality of T cells (HP:0002843)3.09029265
25Encephalitis (HP:0002383)3.05361932
26Keratoconjunctivitis sicca (HP:0001097)3.05015132
27Acute myeloid leukemia (HP:0004808)3.04144370
28Recurrent viral infections (HP:0004429)3.03692276
29Keratoconjunctivitis (HP:0001096)3.03654664
30Abnormality of T cell physiology (HP:0011840)2.93183660
31Pulmonary infiltrates (HP:0002113)2.91311921
32Hemoptysis (HP:0002105)2.85184663
33Eczematoid dermatitis (HP:0000976)2.77269297
34Gastrointestinal infarctions (HP:0005244)2.71640641
35Gingival bleeding (HP:0000225)2.66039776
36Spontaneous hematomas (HP:0007420)2.54565713
37Abnormality of the columella (HP:0009929)2.50733567
38Abnormality of the fingertips (HP:0001211)2.48696171
39Vasculitis (HP:0002633)2.48474708
40Gingivitis (HP:0000230)2.48410614
41Stomatitis (HP:0010280)2.42404878
42Meningitis (HP:0001287)2.39275848
43Arterial thrombosis (HP:0004420)2.38580262
44Abnormality of the nasal septum (HP:0000419)2.38340422
45Progressive cerebellar ataxia (HP:0002073)2.36117803
46Protruding tongue (HP:0010808)2.32542157
47Abnormality of macrophages (HP:0004311)2.28811631
48Recurrent bronchitis (HP:0002837)2.28450981
49Abnormality of the endocardium (HP:0004306)2.23048583
50Cortical visual impairment (HP:0100704)2.21480561
51Leukocytosis (HP:0001974)2.21341997
52Eosinophilia (HP:0001880)2.21182487
53Panhypogammaglobulinemia (HP:0003139)2.15205702
54Mediastinal lymphadenopathy (HP:0100721)2.14303362
55Peritonitis (HP:0002586)2.14181253
56Periodontitis (HP:0000704)2.11942333
57Slow saccadic eye movements (HP:0000514)2.10256571
58Elevated erythrocyte sedimentation rate (HP:0003565)2.09075920
59Neonatal hypoglycemia (HP:0001998)2.07929102
60Episodic fever (HP:0001954)2.03946302
61Seborrheic dermatitis (HP:0001051)2.02997892
62IgG deficiency (HP:0004315)2.01966699
63Stomach cancer (HP:0012126)2.01684795
64Cheilitis (HP:0100825)1.99802445
65Abnormality of incisor morphology (HP:0011063)1.99675876
66Pustule (HP:0200039)1.97733199
67Chest pain (HP:0100749)1.97020644
68Pulmonary embolism (HP:0002204)1.95801668
69Autoimmune hemolytic anemia (HP:0001890)1.95401241
70Gangrene (HP:0100758)1.93030967
71Granulocytopenia (HP:0001913)1.91735574
72Postural instability (HP:0002172)1.89869770
73Prolonged bleeding time (HP:0003010)1.89111539
74Abnormality of the periventricular white matter (HP:0002518)1.87884025
75Anorexia (HP:0002039)1.87201399
76Prostate neoplasm (HP:0100787)1.87140874
77Poikilocytosis (HP:0004447)1.85610579
78Epistaxis (HP:0000421)1.84239033
79Narrow palate (HP:0000189)1.82266854
80Abnormality of pyrimidine metabolism (HP:0004353)1.78705935
81Microcytic anemia (HP:0001935)1.77545490
82Epileptic encephalopathy (HP:0200134)1.76950925
83Inflammation of the large intestine (HP:0002037)1.76127258
84Abnormality of eosinophils (HP:0001879)1.75923458
85Viral hepatitis (HP:0006562)1.75666228
86Thick nail (HP:0001805)1.75266588
87Neoplasm of the tracheobronchial system (HP:0100552)1.74242386
88Hyperventilation (HP:0002883)1.73578294
89Subaortic stenosis (HP:0001682)1.71241127
90Abnormality of the left ventricular outflow tract (HP:0011103)1.71241127
91Spontaneous abortion (HP:0005268)1.70564985
92Premature ovarian failure (HP:0008209)1.70409811
93Truncal obesity (HP:0001956)1.69547996
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68782284
95Absent speech (HP:0001344)1.68725606
96Autoimmune thrombocytopenia (HP:0001973)1.67819579
97Generalized hypopigmentation of hair (HP:0011358)1.66682854
98Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66602095
99Abnormality of polysaccharide metabolism (HP:0011012)1.66602095
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66602095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.28258976
2FRK3.79491987
3TXK3.48603489
4MAP4K12.59184990
5MAP3K142.47821425
6RIPK42.34837498
7PIK3CG2.27511825
8TYK22.25607418
9JAK12.18557901
10FGFR32.07812713
11TAOK32.05259113
12SYK1.91923044
13IRAK11.78384497
14MAP2K31.75887179
15STK381.75718335
16PTK2B1.70574726
17NLK1.65570112
18IRAK41.64238087
19JAK31.63954070
20AKT31.63635392
21BTK1.51942471
22TNK21.50310036
23TEC1.44164209
24YES11.43010452
25SGK21.40426194
26WNK11.40196009
27CDK121.36911334
28KIT1.36507561
29IKBKE1.31853438
30ZAP701.29643988
31CSK1.26916348
32MAP3K21.25047596
33PRKD21.23495849
34FGFR41.22547028
35LYN1.18159901
36HCK1.17768784
37LATS11.15124325
38EPHA31.14557347
39ADRBK21.11804203
40EIF2AK11.10143330
41MAP3K51.09056437
42PRKCQ1.06567210
43ACVR1B1.06238493
44ITK1.04724827
45NUAK11.04589611
46JAK21.04015694
47FGR1.01291078
48MAP3K70.99808652
49LCK0.99767859
50SGK30.96875807
51FES0.92339646
52MARK20.92084490
53STK40.85402648
54IKBKB0.83248388
55NTRK30.82200647
56CDC42BPA0.81495523
57MAP3K60.80301768
58EPHB10.76809246
59BRD40.75129968
60PDK10.74832676
61RET0.74564757
62MAP3K10.73110886
63SGK4940.72744859
64SGK2230.72744859
65BMPR20.72674861
66CAMK40.72543689
67PDGFRB0.72276617
68MAP3K30.71936068
69EIF2AK20.68358558
70EIF2AK30.68204349
71KSR10.66165558
72GRK60.65714046
73PIM10.64433362
74MAP2K60.64392973
75CAMK1D0.64105769
76MELK0.62779911
77IRAK20.62454541
78PIK3CA0.62192049
79CSF1R0.56049189
80PRKCH0.55032507
81STK100.54768790
82MAP2K40.54454560
83HIPK20.52919695
84CHUK0.52686648
85MARK30.52649397
86CAMK1G0.52053019
87TRPM70.50393848
88ERBB20.49405518
89NEK60.48881970
90CCNB10.46638301
91SGK10.46315580
92PRKG10.44902532
93MATK0.44493917
94RAF10.43599609
95CDK60.43528957
96PDPK10.42657232
97FGFR10.38264916
98ADRBK10.38047466
99CAMKK20.37925403
100GRK70.37221874

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.08118124
2Graft-versus-host disease_Homo sapiens_hsa053322.68900109
3Leishmaniasis_Homo sapiens_hsa051402.68130876
4Allograft rejection_Homo sapiens_hsa053302.51079156
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.45036592
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.43434250
7Measles_Homo sapiens_hsa051622.42004219
8Autoimmune thyroid disease_Homo sapiens_hsa053202.32983406
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.25430670
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.17682054
11Osteoclast differentiation_Homo sapiens_hsa043802.15452674
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.10867971
13Type I diabetes mellitus_Homo sapiens_hsa049402.05137946
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.00460161
15Asthma_Homo sapiens_hsa053101.99802173
16Tuberculosis_Homo sapiens_hsa051521.90281906
17Influenza A_Homo sapiens_hsa051641.88856643
18Primary immunodeficiency_Homo sapiens_hsa053401.75930735
19T cell receptor signaling pathway_Homo sapiens_hsa046601.72119266
20B cell receptor signaling pathway_Homo sapiens_hsa046621.62367547
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61267817
22Chemokine signaling pathway_Homo sapiens_hsa040621.61033593
23Toxoplasmosis_Homo sapiens_hsa051451.56523202
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.56027420
25Antigen processing and presentation_Homo sapiens_hsa046121.48625249
26TNF signaling pathway_Homo sapiens_hsa046681.44924449
27Rheumatoid arthritis_Homo sapiens_hsa053231.42290859
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41627608
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41129302
30Hematopoietic cell lineage_Homo sapiens_hsa046401.37491031
31Herpes simplex infection_Homo sapiens_hsa051681.32764110
32Malaria_Homo sapiens_hsa051441.25744635
33Dorso-ventral axis formation_Homo sapiens_hsa043201.21430725
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18536007
35Acute myeloid leukemia_Homo sapiens_hsa052211.14830969
36Hepatitis C_Homo sapiens_hsa051601.12803055
37Hepatitis B_Homo sapiens_hsa051611.11625524
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11319185
39Inositol phosphate metabolism_Homo sapiens_hsa005621.09238553
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05176685
41FoxO signaling pathway_Homo sapiens_hsa040681.03741281
42Insulin resistance_Homo sapiens_hsa049311.00307624
43Prolactin signaling pathway_Homo sapiens_hsa049170.99589260
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98907195
45Pancreatic cancer_Homo sapiens_hsa052120.98805989
46Viral myocarditis_Homo sapiens_hsa054160.98365658
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.96416843
48Platelet activation_Homo sapiens_hsa046110.91756256
49Phagosome_Homo sapiens_hsa041450.91307343
50Chronic myeloid leukemia_Homo sapiens_hsa052200.88242589
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86142851
52Non-small cell lung cancer_Homo sapiens_hsa052230.84817893
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84094621
54Legionellosis_Homo sapiens_hsa051340.79590428
55Lysine degradation_Homo sapiens_hsa003100.74088522
56Pertussis_Homo sapiens_hsa051330.73805668
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72929904
58mTOR signaling pathway_Homo sapiens_hsa041500.72811499
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72424804
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69939581
61Olfactory transduction_Homo sapiens_hsa047400.68202581
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65901338
63Apoptosis_Homo sapiens_hsa042100.64774082
64Epstein-Barr virus infection_Homo sapiens_hsa051690.64372125
65African trypanosomiasis_Homo sapiens_hsa051430.63933499
66Linoleic acid metabolism_Homo sapiens_hsa005910.63170685
67Ether lipid metabolism_Homo sapiens_hsa005650.58510175
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56682634
69Complement and coagulation cascades_Homo sapiens_hsa046100.55871437
70Prostate cancer_Homo sapiens_hsa052150.51918209
71GnRH signaling pathway_Homo sapiens_hsa049120.51620760
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51387467
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50860142
74Type II diabetes mellitus_Homo sapiens_hsa049300.50854814
75Collecting duct acid secretion_Homo sapiens_hsa049660.50615691
76VEGF signaling pathway_Homo sapiens_hsa043700.50495095
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50224350
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.49764952
79Notch signaling pathway_Homo sapiens_hsa043300.47624161
80Caffeine metabolism_Homo sapiens_hsa002320.47484571
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.46591424
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.46406757
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.45278323
84Lysosome_Homo sapiens_hsa041420.43353998
85Circadian entrainment_Homo sapiens_hsa047130.42818062
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.41657635
87Glycerolipid metabolism_Homo sapiens_hsa005610.41546831
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41290050
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.39110610
90Arachidonic acid metabolism_Homo sapiens_hsa005900.38073206
91MAPK signaling pathway_Homo sapiens_hsa040100.37418698
92Morphine addiction_Homo sapiens_hsa050320.35997046
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34436301
94HTLV-I infection_Homo sapiens_hsa051660.34035465
95Choline metabolism in cancer_Homo sapiens_hsa052310.33721509
96Ovarian steroidogenesis_Homo sapiens_hsa049130.32790090
97ErbB signaling pathway_Homo sapiens_hsa040120.32781128
98Phototransduction_Homo sapiens_hsa047440.32622249
99cAMP signaling pathway_Homo sapiens_hsa040240.30677710
100Circadian rhythm_Homo sapiens_hsa047100.29138530

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